WO2024230129A1 - Method and apparatus for processing blood vessel ultrasound image, and device and medium - Google Patents
Method and apparatus for processing blood vessel ultrasound image, and device and medium Download PDFInfo
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- WO2024230129A1 WO2024230129A1 PCT/CN2023/133862 CN2023133862W WO2024230129A1 WO 2024230129 A1 WO2024230129 A1 WO 2024230129A1 CN 2023133862 W CN2023133862 W CN 2023133862W WO 2024230129 A1 WO2024230129 A1 WO 2024230129A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Clinical applications
- A61B8/0891—Clinical applications for diagnosis of blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
Definitions
- the embodiments of the present application relate to the technical field of medical image processing, for example, to a method, device, equipment and medium for processing vascular ultrasound images.
- Intravascular ultrasound is an intravascular imaging method. Since IVUS images are affected by the signal-to-noise ratio of the ultrasound system and the complex imaging environment, the recognition of different tissue components such as blood, fibrous plaques, and calcified plaques in blood vessels is poor. In addition, the dynamic range of the image displayed by the display device cannot match the dynamic range of the transducer, which will also increase the loss of the dynamic range of the intravascular ultrasound image.
- time gain compensation and logarithmic compression methods are mostly used to control the brightness and contrast of the image to improve the quality of vascular ultrasound images.
- the above methods rely more on experience and subjective evaluation, and the image processing effect is unstable.
- the embodiments of the present application provide a vascular ultrasound image processing method, device, equipment and medium, which can improve the brightness contrast of different components in the blood vessel and enhance the vascular ultrasound image effect.
- an embodiment of the present application provides a method for processing a vascular ultrasound image, the method comprising:
- the target brightness mapping parameter is a parameter determined by analyzing multiple groups of sample ultrasonic signals collected under the same sampling conditions as the ultrasonic signal in a preset hyperspace;
- the brightness of the initial blood vessel ultrasonic image is adjusted based on the target brightness mapping parameter to obtain a target blood vessel ultrasonic image.
- an embodiment of the present application further provides a vascular ultrasound image processing device, the device comprising:
- an image generation module configured to acquire an ultrasonic signal of a target blood vessel object and obtain an initial blood vessel ultrasonic image based on the ultrasonic signal
- An image processing parameter acquisition module configured to determine a target brightness mapping parameter that matches the ultrasonic signal; wherein the target brightness mapping parameter is a parameter determined by analyzing a plurality of groups of sample ultrasonic signals collected under the same sampling conditions as the ultrasonic signal in a preset hyperspace;
- the image processing module is configured to adjust the brightness of the initial blood vessel ultrasonic image based on the target brightness mapping parameter to obtain a target blood vessel ultrasonic image.
- an embodiment of the present application further provides a computer device, the computer device comprising:
- a memory configured to store at least one program
- the at least one processor When the at least one program is executed by the at least one processor, the at least one processor implements the vascular ultrasound image processing method provided in any embodiment of the present application.
- an embodiment of the present application further provides a computer-readable storage medium, on which a computer program is stored, and when the program is executed by a processor, a vascular ultrasound image processing method as provided in any embodiment of the present application is implemented.
- FIG1 is a flow chart of a method for processing vascular ultrasound images provided in an embodiment of the present application
- FIG2 is a flow chart of a method for processing a vascular ultrasound image provided by an embodiment of the present application
- FIG3 is a schematic diagram of the structure of a blood vessel ultrasonic image processing device provided in an embodiment of the present application.
- FIG4 is a schematic diagram of the structure of a computer device provided in an embodiment of the present application.
- FIG1 is a flow chart of a vascular ultrasound image processing method provided by an embodiment of the present application. This embodiment is applicable to a scenario in which a vascular ultrasound image is obtained by signal processing based on an intravascular ultrasound signal.
- the method can be executed by a vascular ultrasound image processing device, which can be implemented by software and/or hardware. Integrated into computer equipment with application development capabilities.
- the blood vessel ultrasound image processing method of this embodiment includes the following steps:
- the target blood vessel object may be a blood vessel object that can be imaged by signal acquisition and imaging by an intravascular ultrasound imaging device to reflect the condition of the inner wall of the blood vessel.
- the ultrasonic signal After acquiring the ultrasonic signal of the target vascular object, the ultrasonic signal can be processed to obtain the initial vascular ultrasonic image, and the data signal can be converted into an image for representation.
- Each vascular ultrasonic image has a corresponding brightness mapping curve, which reflects the mapping relationship between the pixel gray value in the vascular ultrasonic image and the vascular ultrasonic signal intensity.
- the initial vascular ultrasonic image corresponds to an initial brightness mapping curve.
- the acquired ultrasound signals can be respectively input into a plurality of preset bandpass filters of different filtering frequency bands to obtain ultrasound filter signals of corresponding frequency bands; then, time gain compensation is performed on the plurality of ultrasound filter signals respectively, and the compensated signals are superimposed to obtain processed ultrasound signals; and further, an initial vascular ultrasound image is obtained according to the processed ultrasound signals.
- the ultrasound signal emitted by the ultrasound transducer usually penetrates the blood first and then the tissue; its actual attenuation rate is an unknown variable, and different attenuation rates may be applied at different wavelengths (frequencies).
- the attenuation rate may be adjusted based on the experience of technicians in the field, or the gain value of the time gain compensation may be adjusted directly based on the empirical value.
- the grayscale value display effect of the initial vascular ultrasound image is further adjusted, that is, the initial brightness mapping curve is changed.
- the target brightness mapping parameter is a parameter determined by analyzing multiple groups of sample ultrasonic signals collected under the same sampling conditions as the ultrasonic signal in a preset hyperspace.
- the same sampling conditions can be The situation of signal acquisition of blood vessels by the same signal acquisition device.
- Each signal acquisition device with different models or equipment parameters will have different signal dynamic ranges, and the corresponding target brightness mapping parameters are different.
- the signal acquisition device can be an ultrasonic transducer that can realize ultrasonic signal conversion, transmission and reception.
- the target brightness mapping parameter is a parameter that has been analyzed and verified and is used to process ultrasonic images.
- the preset signal analysis dimensions may include parameters such as the intensity (brightness) of the ultrasound signal, the mean value of the signal intensity, the variance of the signal intensity, and the signal texture characteristics, which present different performance results for different intravascular tissue components, thereby enabling different vascular tissue components to be well distinguished.
- the preset hyperspace is a multi-dimensional stereoscopic space established based on the signals of the above multiple dimensions. Furthermore, the analysis results based on the multiple dimensions can be analyzed in the preset hyperspace to obtain a set of brightness mapping parameters that enable different vascular tissue components to be well distinguished.
- ultrasonic signal sample data can be collected for different signal acquisition devices in advance, and a universal brightness mapping parameter matching the corresponding signal acquisition device can be determined based on a large amount of data analysis.
- the preset brightness mapping parameter table can be queried based on the device parameters of the signal acquisition device corresponding to the initial ultrasonic image to be processed to obtain the target brightness mapping parameters.
- S130 Adjust the brightness of the initial vascular ultrasound image based on the target brightness mapping parameter to obtain a target vascular ultrasound image.
- the adjusting the brightness of the initial vascular ultrasound image based on the target brightness mapping parameters may be a process of updating an initial brightness mapping curve according to the target brightness mapping parameters, and obtaining a target brightness mapping curve through the target brightness mapping parameters, thereby obtaining a target vascular ultrasound image.
- the technical solution of this embodiment is to obtain an initial vascular ultrasound image based on the ultrasound signal after acquiring the ultrasound signal of the target vascular object; then determine the target brightness mapping parameters that match the ultrasound signal; and adjust the brightness of the initial vascular ultrasound image based on the target brightness mapping parameters to obtain the target vascular ultrasound image to improve the image quality; wherein the target brightness mapping parameters are parameters determined by analyzing multiple groups of sample ultrasound signals collected under the same sampling conditions as the ultrasound signal in a preset hyperspace.
- the technical solution of this embodiment solves the problem of intravascular ultrasound image in the related art.
- the problem of unstable image processing effect when the dynamic display range of the image is adjusted can be solved by efficiently and stably adjusting the dynamic range of the vascular ultrasound image during high real-time intravascular ultrasound imaging to improve the quality of the vascular image.
- FIG2 is a flow chart of a vascular ultrasound image processing method provided in an embodiment of the present application.
- This embodiment and the vascular ultrasound image processing method in the above embodiment belong to the same inventive concept, and further describes the determination process of the target brightness mapping parameter.
- the method can be executed by a vascular ultrasound image processing device, which can be implemented by software and/or hardware and integrated into a computer device with application development function.
- the blood vessel ultrasound image processing method of this embodiment includes the following steps:
- the target signal acquisition device can be any type of device used for intravascular ultrasound imaging and that requires exploration of more suitable brightness mapping parameters, such as an ultrasonic transducer that can realize ultrasound signal conversion, transmission, and reception. This is because different devices have different corresponding ultrasound signal conversion and signal acquisition capabilities, so it is necessary to determine a brightness mapping parameter that is more suitable for each different type of signal acquisition device.
- determining the brightness mapping parameters that are suitable for each different type of signal acquisition device can be achieved by analyzing a large number of sample ultrasound signals collected by each signal acquisition device for the target vascular object.
- the process of performing signal preprocessing on multiple groups of sample ultrasonic signals to obtain corresponding spatial frequency signal graphs may include the following steps:
- synchronous compression wavelet transform is performed on the signals at each sampling angle in the multiple groups of sample ultrasonic signals to obtain the signal time-frequency diagrams corresponding to each sampling angle in the multiple groups of sample ultrasonic signals.
- ultrasound signals are usually represented by polar coordinate data.
- each angle in the polar coordinate system corresponds to a time signal sequence.
- the sample ultrasound signal of each angle is synchronously compressed by wavelet transform to construct channels corresponding to multiple ultrasound signals of different frequencies.
- the number of channels is set to 3-5, so as to obtain the signal time-frequency diagram corresponding to each sampling angle of the sample ultrasound signal, which is a three-dimensional diagram determined by time-frequency-signal intensity value.
- the signal time-frequency diagrams corresponding to multiple sampling angles are combined to obtain a spatial frequency signal diagram in the form of a three-dimensional grid, that is, the signal time-frequency diagrams at different angles are superimposed and displayed in one space to form a four-dimensional data diagram.
- neural network image recognition can be used, for example, different vascular components can be identified, such as blood, tissue, fibrous plaque, calcified plaque, stent and other tissue components.
- different vascular tissues in multiple spatial frequency signal graphs are marked in advance, a neural network model that can identify different vascular tissue components is trained, and the spatial frequency signal graph is input into the neural network model to obtain the corresponding recognition results of different vascular tissue components.
- manual labeling or other methods that can realize vascular tissue component identification can also be used.
- the texture description parameter can be at least one parameter of a gray level co-occurrence matrix, a homogeneous texture descriptor, and an edge histogram descriptor.
- a hyperspace can be established with multiple preset signal analysis dimensions, and then the distribution area of each vascular tissue in the hyperspace can be determined based on the data of the multiple preset signal analysis dimensions of each vascular tissue.
- a vascular tissue component in a spatial frequency signal graph can correspond to a point in the hyperspace, and vascular tissue components of the same category in multiple spatial frequency signal graphs obtained after processing multiple sample ultrasound signals correspond to multiple points in the hyperspace, which can form a point cloud.
- the brightness mapping curve value corresponding to the initial vascular ultrasound image ie, the initial brightness mapping curve value
- the distance between the centers of the point clouds composed of different types of vascular tissue components is calculated.
- the brightness mapping curve value that makes the distance between the center points of the distribution areas of the multiple vascular tissues the maximum distance value is determined as the target brightness mapping parameter.
- the brightness curve mapping parameters can maximize the distance between the centers of the point clouds composed of different categories of vascular tissue components, that is, the different categories of vascular tissue components have better distinction.
- the distance calculation may be implemented by using Euclidean distance or other distance calculation rules, or may be calculated and determined by using artificial intelligence image recognition.
- the target brightness mapping parameters are determined, they can be applied in the process of processing relevant intravascular ultrasound images.
- S250 Adjust the brightness of the initial vascular ultrasound image based on the target brightness mapping parameter to obtain a target vascular ultrasound image.
- the technical solution of this embodiment is to first use the target signal acquisition device to perform a large number of ultrasonic signal sampling, collect multiple groups of sample ultrasonic signals, and perform signal preprocessing on the multiple groups of sample ultrasonic signals respectively to obtain the corresponding spatial frequency signal map; then identify different vascular tissues in the spatial frequency signal map, and count the data of multiple preset signal analysis dimensions of each vascular tissue; based on the data of the multiple preset signal analysis dimensions of each vascular tissue, analyze and determine the target brightness mapping parameters in the hyperspace formed by the multiple preset signal analysis dimensions.
- an initial vascular ultrasonic image is obtained based on the ultrasonic signal; then determine the target brightness mapping parameters that match the signal acquisition device that collects the ultrasonic signal; and adjust the brightness of the initial vascular ultrasonic image based on the target brightness mapping parameters to obtain the target vascular ultrasonic image to improve the image quality; wherein the target brightness mapping parameters are parameters determined based on the analysis of the multiple groups of sample ultrasonic signals collected by the signal acquisition device in the preset hyperspace.
- Figure 3 is a structural schematic diagram of a vascular ultrasound image processing device provided in an embodiment of the present application. This embodiment can be applied to a scenario in which a vascular ultrasound image is obtained by performing signal processing based on an intravascular ultrasound signal.
- the device can be implemented by software and/or hardware and integrated into a computer terminal device with application development capabilities.
- the blood vessel ultrasound image processing device includes: an image generation module 310, an image processing parameter A data acquisition module 320 and an image processing module 330.
- the image generation module 310 is configured to acquire an ultrasonic signal of a target vascular object and obtain an initial vascular ultrasonic image based on the ultrasonic signal;
- the image processing parameter acquisition module 320 is configured to determine a target brightness mapping parameter that matches the ultrasonic signal;
- the image processing module 330 is configured to adjust the brightness of the initial vascular ultrasonic image based on the target brightness mapping parameter to obtain a target vascular ultrasonic image; wherein the target brightness mapping parameter is a parameter determined by analyzing multiple groups of sample ultrasonic signals collected under the same sampling conditions as the ultrasonic signal in a preset hyperspace.
- the technical solution of this embodiment is to obtain an initial vascular ultrasound image based on the ultrasound signal after acquiring the ultrasound signal of the target vascular object; then determine the target brightness mapping parameters that match the ultrasound signal; and adjust the brightness of the initial vascular ultrasound image based on the target brightness mapping parameters to obtain the target vascular ultrasound image to improve the image quality; wherein the target brightness mapping parameters are parameters determined by analyzing multiple groups of sample ultrasound signals collected under the same sampling conditions as the ultrasound signal in a preset hyperspace.
- the technical solution of this embodiment solves the problem of unstable image processing effect when adjusting the dynamic display range of intravascular ultrasound images in related technologies, and can achieve efficient and stable adjustment of the dynamic range of vascular ultrasound images in a highly real-time intravascular ultrasound imaging process to improve the quality of vascular images.
- the vascular ultrasound image processing device further includes a parameter analysis module configured to analyze and determine the target brightness mapping parameters in a preset hyperspace based on a plurality of groups of sample ultrasound signals acquired under the same sampling conditions as the ultrasound signal;
- the parameter analysis module is set to:
- the target brightness mapping parameters are analyzed and determined in a hyperspace formed by the multiple preset signal analysis dimensions.
- the parameter analysis module is set to:
- the signal time-frequency diagrams corresponding to multiple sampling angles are combined to obtain a spatial frequency signal diagram in the form of a three-dimensional grid.
- the parameter analysis module is set to:
- the signal strength value, signal strength mean, signal strength variance corresponding to the vascular tissue and the texture description parameters of the region where each vascular tissue is located are respectively counted.
- the parameter analysis module is set to:
- the brightness mapping curve value corresponding to the initial blood vessel ultrasonic image is adjusted, and the brightness mapping curve value that makes the distance between the center points of the distribution areas of the plurality of blood vessel tissues the maximum distance value is determined as the target brightness mapping parameter.
- the image generation module 310 is configured to:
- the initial blood vessel ultrasonic image is obtained according to the processed ultrasonic signal.
- the ultrasonic signal is acquired by a signal acquisition device, and the image processing parameter acquisition module 320 is set to:
- the preset brightness mapping parameter table is queried according to the device parameters of the signal acquisition device to obtain the target brightness mapping parameters.
- the vascular ultrasonic image processing device provided in the embodiment of the present application can execute the vascular ultrasonic image processing method provided in any embodiment of the present application, and has the corresponding functional modules and effects of the execution method.
- FIG4 is a schematic diagram of the structure of a computer device provided in an embodiment of the present application.
- FIG4 shows a block diagram of an exemplary computer device 12 suitable for implementing the implementation of the present application.
- the computer device 12 shown in FIG4 is only an example and should not bring any limitation to the functions and scope of use of the embodiment of the present application.
- the computer device 12 can be any terminal device with computing capabilities, such as intelligent controllers and servers, mobile phones and other terminal devices.
- computer device 12 is in the form of a general purpose computing device.
- Components of computer device 12 may include, but are not limited to, one or more processors or processing units 16, system memory 28, and bus 18 connecting various system components (including system memory 28 and processing unit 16).
- Bus 18 represents one or more of several types of bus structures, including a memory bus or memory controller, a peripheral bus, an accelerated graphics port, a processor, or a local bus using any of a variety of bus structures.
- these architectures include, but are not limited to, an Instruction Set Architecture (ISA) bus, a Micro Channel Architecture (MAC) bus, an enhanced ISA bus, a Video Electronics Standards Association (VESA) local bus, and a Peripheral Component Interconnect (PCI) bus.
- ISA Instruction Set Architecture
- MAC Micro Channel Architecture
- VESA Video Electronics Standards Association
- PCI Peripheral Component Interconnect
- the computer device 12 typically includes a variety of computer system readable media. These media can be any available media that can be accessed by the computer device 12, including volatile and non-volatile media, removable and non-removable media.
- the system memory 28 may include computer system readable media in the form of volatile memory, such as random access memory (RAM) 30 and/or cache memory 32.
- the computer device 12 may further include other removable/non-removable, volatile/non-volatile computer system storage media.
- the storage system 34 may be used to read and write non-removable, non-volatile magnetic media (not shown in FIG. 4 , commonly referred to as a “hard drive”).
- a disk drive for reading and writing removable non-volatile disks such as “floppy disks” and an optical disk drive for reading and writing removable non-volatile optical disks (such as read-only memories (Compact Disc Read-Only Memory, CD-ROM), digital video disks (Digital Video Disc-Read Only Memory, DVD-ROM) or other optical media)
- each drive may be connected to the bus 18 via one or more data media interfaces.
- the system memory 28 may include at least one program product having a set (eg, at least one) of program modules.
- the program modules are configured to perform the functions of various embodiments of the present application.
- a program/utility 40 having a set (at least one) of program modules 42 may be stored, for example, in system memory 28, such program modules 42 including, but not limited to, an operating system, one or more application programs, other program modules, and program data, each of which or some combination may include an implementation of a network environment.
- Program modules 42 generally perform the functions and/or methods of the embodiments described herein.
- the computer device 12 may also communicate with one or more external devices 14 (e.g., keyboard, pointing device, display 24, etc.), one or more devices that enable a user to interact with the computer device 12, and/or any device that enables the computer device 12 to communicate with one or more other computing devices (e.g., network card, modem, etc.). Such communication may be performed through an input/output (I/O) interface 22.
- the computer device 12 may also communicate with one or more networks, such as a local area network (LAN), a wide area network (WAN), and/or a public network (e.g., the Internet) through a network adapter 20. As shown in FIG. 4 , the network adapter 20 communicates with other modules of the computer device 12 through a bus 18.
- LAN local area network
- WAN wide area network
- public network e.g., the Internet
- the processing unit 16 executes a variety of functional applications and data processing by running the program stored in the system memory 28, for example, implementing the vascular ultrasound image processing method provided by the embodiment of the present invention, the method comprising:
- the target brightness mapping parameter is a parameter determined by analyzing multiple groups of sample ultrasonic signals collected under the same sampling conditions as the ultrasonic signal in a preset hyperspace;
- the brightness of the initial blood vessel ultrasonic image is adjusted based on the target brightness mapping parameter to obtain a target blood vessel ultrasonic image.
- the present application also provides a computer-readable storage medium on which a computer program is stored.
- the program is executed by a processor, the method for processing a vascular ultrasound image provided in any embodiment of the present application is implemented.
- the method includes:
- the target brightness mapping parameter is based on a plurality of groups of sample ultrasonic signals collected under the same sampling conditions as the ultrasonic signal in a preset Parameters determined by analysis in hyperspace;
- the brightness of the initial blood vessel ultrasonic image is adjusted based on the target brightness mapping parameter to obtain a target blood vessel ultrasonic image.
- the computer storage medium of the embodiment of the present application may adopt any combination of one or more computer-readable media.
- the computer-readable medium may be a computer-readable signal medium or a computer-readable storage medium.
- the computer-readable storage medium may be, for example, but not limited to: an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, device or device, or any combination of the above. More specific examples of computer-readable storage media (a non-exhaustive list) include: an electrical connection with one or more wires, a portable computer disk, a hard disk, RAM, ROM, an erasable programmable read-only memory (EPROM) or flash memory, optical fiber, CD-ROM, an optical storage device, a magnetic storage device, or any suitable combination of the above.
- a computer-readable storage medium may be any tangible medium containing or storing a program that can be used by or in conjunction with an instruction execution system, device or device.
- Computer-readable signal media may include data signals propagated in baseband or as part of a carrier wave, which carry computer-readable program code. Such propagated data signals may take a variety of forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination of the above. Computer-readable signal media may also be any computer-readable medium other than a computer-readable storage medium, which may send, propagate, or transmit a program for use by or in conjunction with an instruction execution system, apparatus, or device.
- the program code contained on the computer-readable medium can be transmitted using any appropriate medium, including but not limited to: wireless, wire, optical cable, radio frequency (RF), etc., or any suitable combination of the above.
- any appropriate medium including but not limited to: wireless, wire, optical cable, radio frequency (RF), etc., or any suitable combination of the above.
- the computer program code for performing the operations of the present application may be written in one or more programming languages or a combination thereof, including object-oriented programming languages such as Java, Smalltalk, C++, and conventional procedural programming languages such as "C" or similar programming languages.
- the program code may be executed entirely on the user's computer, partially on the user's computer, as a separate software package, partially on the user's computer and partially on a remote computer, or entirely on a remote computer or server.
- the remote computer may be connected to the user's computer via any type of network, including a LAN or WAN. Alternatively, it can be connected to an external computer (for example, through the Internet using an Internet service provider).
- the above-mentioned multiple modules or multiple steps of the present application can be implemented by a general-purpose computing device, they can be concentrated on a single computing device, or distributed on a network composed of multiple computing devices, optionally, they can be implemented by a program code executable by a computer device, so that they can be stored in a storage device and executed by the computing device, or they can be made into multiple integrated circuit modules respectively, or multiple modules or steps therein can be made into a single integrated circuit module for implementation.
- the present application is not limited to any specific combination of hardware and software.
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Abstract
Description
本申请要求在2023年05月11日提交中国专利局、申请号为202310531607.1的中国专利申请的优先权,该申请的全部内容通过引用结合在本申请中。This application claims the priority of the Chinese patent application filed with the China Patent Office on May 11, 2023, with application number 202310531607.1, the entire contents of which are incorporated by reference into this application.
本申请实施例涉及医学图像处理技术领域,例如涉及一种血管超声图像处理方法、装置、设备和介质。The embodiments of the present application relate to the technical field of medical image processing, for example, to a method, device, equipment and medium for processing vascular ultrasound images.
血管内超声(Intravascular ultrasound,IVUS)是一种血管内的成像方式,由于IVUS图像受超声系统信噪比以及成像环境复杂的影响,血管内血液、纤维斑块、钙化斑块等不同组织成分辨识度较差,而且显示设备显示图像的动态范围无法匹配换能器的动态范围,也会增大血管内超声图像动态范围的损失。Intravascular ultrasound (IVUS) is an intravascular imaging method. Since IVUS images are affected by the signal-to-noise ratio of the ultrasound system and the complex imaging environment, the recognition of different tissue components such as blood, fibrous plaques, and calcified plaques in blood vessels is poor. In addition, the dynamic range of the image displayed by the display device cannot match the dynamic range of the transducer, which will also increase the loss of the dynamic range of the intravascular ultrasound image.
通常在血管内超声成像的亮度模式下,大多使用时间增益补偿与对数压缩方法控制图像的亮度与对比度,来提高血管超声图像质量。但是,上述方法更多依赖于经验与主观评估,图像处理效果不稳定。Usually, in the brightness mode of intravascular ultrasound imaging, time gain compensation and logarithmic compression methods are mostly used to control the brightness and contrast of the image to improve the quality of vascular ultrasound images. However, the above methods rely more on experience and subjective evaluation, and the image processing effect is unstable.
发明内容Summary of the invention
本申请实施例提供了一种血管超声图像处理方法、装置、设备和介质,可以提高血管中不同成分的亮度对比度,提升血管超声图像效果。The embodiments of the present application provide a vascular ultrasound image processing method, device, equipment and medium, which can improve the brightness contrast of different components in the blood vessel and enhance the vascular ultrasound image effect.
第一方面,本申请实施例提供了一种血管超声图像处理方法,该方法包括:In a first aspect, an embodiment of the present application provides a method for processing a vascular ultrasound image, the method comprising:
获取目标血管对象的超声信号,并基于所述超声信号得到初始血管超声图像;Acquire an ultrasonic signal of a target blood vessel object, and obtain an initial blood vessel ultrasonic image based on the ultrasonic signal;
确定与所述超声信号匹配的目标亮度映射参数;其中,所述目标亮度映射参数是基于与所述超声信号相同的采样条件下采集的多组样本超声信号在预设超空间中分析确定的参数;Determine a target brightness mapping parameter that matches the ultrasonic signal; wherein the target brightness mapping parameter is a parameter determined by analyzing multiple groups of sample ultrasonic signals collected under the same sampling conditions as the ultrasonic signal in a preset hyperspace;
基于所述目标亮度映射参数对所述初始血管超声图像的亮度进行调整,得到目标血管超声图像。The brightness of the initial blood vessel ultrasonic image is adjusted based on the target brightness mapping parameter to obtain a target blood vessel ultrasonic image.
第二方面,本申请实施例还提供了一种血管超声图像处理装置,该装置包括: In a second aspect, an embodiment of the present application further provides a vascular ultrasound image processing device, the device comprising:
图像生成模块,设置为获取目标血管对象的超声信号,并基于所述超声信号得到初始血管超声图像;an image generation module, configured to acquire an ultrasonic signal of a target blood vessel object and obtain an initial blood vessel ultrasonic image based on the ultrasonic signal;
图像处理参数获取模块,设置为确定与所述超声信号匹配的目标亮度映射参数;其中,所述目标亮度映射参数是基于与所述超声信号相同的采样条件下采集的多组样本超声信号在预设超空间中分析确定的参数;An image processing parameter acquisition module, configured to determine a target brightness mapping parameter that matches the ultrasonic signal; wherein the target brightness mapping parameter is a parameter determined by analyzing a plurality of groups of sample ultrasonic signals collected under the same sampling conditions as the ultrasonic signal in a preset hyperspace;
图像处理模块,设置为基于所述目标亮度映射参数对所述初始血管超声图像的亮度进行调整,得到目标血管超声图像。The image processing module is configured to adjust the brightness of the initial blood vessel ultrasonic image based on the target brightness mapping parameter to obtain a target blood vessel ultrasonic image.
第三方面,本申请实施例还提供了一种计算机设备,所述计算机设备包括:In a third aspect, an embodiment of the present application further provides a computer device, the computer device comprising:
至少一个处理器;at least one processor;
存储器,设置为至少存储一个程序;a memory configured to store at least one program;
当所述至少一个程序被所述至少一个处理器执行,使得所述至少一个处理器实现如本申请任意实施例所提供的血管超声图像处理方法。When the at least one program is executed by the at least one processor, the at least one processor implements the vascular ultrasound image processing method provided in any embodiment of the present application.
第四方面,本申请实施例还提供了一种计算机可读存储介质,所述存储介质上存储有计算机程序,该程序被处理器执行时实现如本申请任意实施例所提供的血管超声图像处理方法。In a fourth aspect, an embodiment of the present application further provides a computer-readable storage medium, on which a computer program is stored, and when the program is executed by a processor, a vascular ultrasound image processing method as provided in any embodiment of the present application is implemented.
图1为本申请实施例提供的一种血管超声图像处理方法的流程图;FIG1 is a flow chart of a method for processing vascular ultrasound images provided in an embodiment of the present application;
图2为本申请实施例提供的一种血管超声图像处理方法的流程图;FIG2 is a flow chart of a method for processing a vascular ultrasound image provided by an embodiment of the present application;
图3为本申请实施例提供的一种血管超声图像处理装置的结构示意图;FIG3 is a schematic diagram of the structure of a blood vessel ultrasonic image processing device provided in an embodiment of the present application;
图4为本申请实施例提供的一种计算机设备的结构示意图。FIG4 is a schematic diagram of the structure of a computer device provided in an embodiment of the present application.
下面结合附图和实施例对本申请进行说明。此处所描述的具体实施例仅仅用于解释本申请,而非对本申请的限定。为了便于描述,附图中仅示出了与本申请相关的部分而非全部结构。The present application is described below in conjunction with the accompanying drawings and embodiments. The specific embodiments described herein are only used to explain the present application, rather than to limit the present application. For ease of description, only parts related to the present application, rather than all structures, are shown in the accompanying drawings.
图1为本申请实施例提供的一种血管超声图像处理方法的流程图,本实施例可适用于基于血管内超声信号进行信号处理得到血管超声图像的场景。该方法可以由血管超声图像处理装置执行,该装置可以由软件和/或硬件的方式来实现, 集成于具有应用开发功能的计算机设备中。FIG1 is a flow chart of a vascular ultrasound image processing method provided by an embodiment of the present application. This embodiment is applicable to a scenario in which a vascular ultrasound image is obtained by signal processing based on an intravascular ultrasound signal. The method can be executed by a vascular ultrasound image processing device, which can be implemented by software and/or hardware. Integrated into computer equipment with application development capabilities.
如图1所示,本实施例的血管超声图像处理方法包括以下步骤:As shown in FIG1 , the blood vessel ultrasound image processing method of this embodiment includes the following steps:
S110、获取目标血管对象的超声信号,并基于所述超声信号得到初始血管超声图像。S110 , acquiring an ultrasonic signal of a target blood vessel object, and obtaining an initial blood vessel ultrasonic image based on the ultrasonic signal.
目标血管对象可以是能够通过血管内超声成像设备进行信号采集并成像,以反映血管内壁情况的血管对象。The target blood vessel object may be a blood vessel object that can be imaged by signal acquisition and imaging by an intravascular ultrasound imaging device to reflect the condition of the inner wall of the blood vessel.
在获取到目标血管对象的超声信号之后,便可以对超声信号进行处理得到初始血管超声图像,将数据信号转换为图像进行表示。每一个血管超声图像均会有一个对应的亮度映射曲线,其反应血管超声图像中像素灰度值与血管超声信号强度之间的映射关系。相应的,初始血管超声图像则对应一个初始亮度映射曲线。After acquiring the ultrasonic signal of the target vascular object, the ultrasonic signal can be processed to obtain the initial vascular ultrasonic image, and the data signal can be converted into an image for representation. Each vascular ultrasonic image has a corresponding brightness mapping curve, which reflects the mapping relationship between the pixel gray value in the vascular ultrasonic image and the vascular ultrasonic signal intensity. Correspondingly, the initial vascular ultrasonic image corresponds to an initial brightness mapping curve.
在一种可选的方式中,可以将获取到的超声信号分别输入到多个不同滤波频段的预设带通滤波器,得到对应频段的超声滤波信号;然后,分别对多个所述超声滤波信号进行时间增益补偿,并将补偿后的信号进行叠加,得到处理后超声信号;进而,根据处理后超声信号得到初始血管超声图像。In an optional manner, the acquired ultrasound signals can be respectively input into a plurality of preset bandpass filters of different filtering frequency bands to obtain ultrasound filter signals of corresponding frequency bands; then, time gain compensation is performed on the plurality of ultrasound filter signals respectively, and the compensated signals are superimposed to obtain processed ultrasound signals; and further, an initial vascular ultrasound image is obtained according to the processed ultrasound signals.
时间增益补偿的增益值可以是通过公式为T(r)=1-e-βr,其中r为距超声换能器距离,β=ln10αf/20,α是衰减参数,其单位为f是以MHz为单位的换能器频率。The gain value of the time gain compensation can be calculated by the formula T(r)=1-e- βr , where r is the distance from the ultrasonic transducer, β=ln10 αf/20 , and α is the attenuation parameter, and its unit is f is the transducer frequency in MHz.
在血管内超声信号成像过程中,通常超声换能器发出的超声信号首先穿透血液,然后穿透组织;其真实的衰减率是一个不可知的变量,在不同的波长(频率)可应用不同的衰减率,可以依据领域内技术人员经验进行衰减率的调整,或者直接根据经验值调整时间增益补偿的增益值。During intravascular ultrasound signal imaging, the ultrasound signal emitted by the ultrasound transducer usually penetrates the blood first and then the tissue; its actual attenuation rate is an unknown variable, and different attenuation rates may be applied at different wavelengths (frequencies). The attenuation rate may be adjusted based on the experience of technicians in the field, or the gain value of the time gain compensation may be adjusted directly based on the empirical value.
S120、确定与所述超声信号匹配的目标亮度映射参数。S120: Determine a target brightness mapping parameter that matches the ultrasonic signal.
在本实施例中,为了使最终的血管超声图像能够有更大的动态显示范围,呈现更好的图像视觉效果,还会进一步的对初始血管超声图像的灰度值显示效果进行调整,即改变初始亮度映射曲线。In this embodiment, in order to enable the final vascular ultrasound image to have a larger dynamic display range and present a better image visual effect, the grayscale value display effect of the initial vascular ultrasound image is further adjusted, that is, the initial brightness mapping curve is changed.
所述目标亮度映射参数是基于与所述超声信号相同的采样条件下采集的多组样本超声信号在预设超空间中分析确定的参数。其中相同的采样条件可以是 通过相同的信号采集器件对血管进行信号采集的情况。每一个型号或设备参数不同的信号采集器件会有不同的信号动态范围,对应的目标亮度映射参数是不同的。其中,信号采集器件可以是能够实现超声信号转换、发射以及接收的超声换能器。目标亮度映射参数对于对应的信号采集器件来说,是经过分析验证过的,用于处理超声图像的参数。The target brightness mapping parameter is a parameter determined by analyzing multiple groups of sample ultrasonic signals collected under the same sampling conditions as the ultrasonic signal in a preset hyperspace. The same sampling conditions can be The situation of signal acquisition of blood vessels by the same signal acquisition device. Each signal acquisition device with different models or equipment parameters will have different signal dynamic ranges, and the corresponding target brightness mapping parameters are different. Among them, the signal acquisition device can be an ultrasonic transducer that can realize ultrasonic signal conversion, transmission and reception. For the corresponding signal acquisition device, the target brightness mapping parameter is a parameter that has been analyzed and verified and is used to process ultrasonic images.
预设信号分析维度可以包括超声信号的强度(亮度)、信号强度均值、信号强度方差以及信号纹理特征等在不同血管内组织成分呈现不同表现结果的参数,从而能够使不同的血管组织成分很好的区分。其中,预设超空间即基于上述多个维度的信号建立起的多维立体空间。进而,基于多维度的分析结果可以在预设超空间中进行分析,得到一组使不同的血管组织成分很好的区分的亮度映射参数。The preset signal analysis dimensions may include parameters such as the intensity (brightness) of the ultrasound signal, the mean value of the signal intensity, the variance of the signal intensity, and the signal texture characteristics, which present different performance results for different intravascular tissue components, thereby enabling different vascular tissue components to be well distinguished. Among them, the preset hyperspace is a multi-dimensional stereoscopic space established based on the signals of the above multiple dimensions. Furthermore, the analysis results based on the multiple dimensions can be analyzed in the preset hyperspace to obtain a set of brightness mapping parameters that enable different vascular tissue components to be well distinguished.
在一种可选的实施方式中,可以预先针对不同的信号采集器件分别进行超声信号样本数据采集,并基于大量的数据分析之后,确定一个通用的与对应的信号采集器件匹配的亮度映射参数。在需要使用相关的亮度映射参数的情况下,可以待处理的初始超声图像对应的信号采集器件的设备参数查询预设亮度映射参数表,得到目标亮度映射参数。In an optional implementation, ultrasonic signal sample data can be collected for different signal acquisition devices in advance, and a universal brightness mapping parameter matching the corresponding signal acquisition device can be determined based on a large amount of data analysis. When the relevant brightness mapping parameters need to be used, the preset brightness mapping parameter table can be queried based on the device parameters of the signal acquisition device corresponding to the initial ultrasonic image to be processed to obtain the target brightness mapping parameters.
S130、基于所述目标亮度映射参数对所述初始血管超声图像的亮度进行调整,得到目标血管超声图像。S130: Adjust the brightness of the initial vascular ultrasound image based on the target brightness mapping parameter to obtain a target vascular ultrasound image.
所述基于所述目标亮度映射参数对所述初始血管超声图像的亮度进行调整,可以是根据目标亮度映射参数对初始亮度映射曲线经更新的过程,通过目标亮度映射参数得到目标亮度映射曲线,从而得到目标血管超声图像。The adjusting the brightness of the initial vascular ultrasound image based on the target brightness mapping parameters may be a process of updating an initial brightness mapping curve according to the target brightness mapping parameters, and obtaining a target brightness mapping curve through the target brightness mapping parameters, thereby obtaining a target vascular ultrasound image.
基于该步骤的调整,可以使血管超声图像中不同的血管组织成分的区分度更高,视觉效果更佳。Based on the adjustment of this step, different vascular tissue components in the vascular ultrasound image can be more distinguished and the visual effect can be better.
本实施例的技术方案,通过在获取目标血管对象的超声信号之后,基于所述超声信号得到初始血管超声图像;然后确定与所述超声信号匹配的目标亮度映射参数;并基于所述目标亮度映射参数对所述初始血管超声图像的亮度进行调整,得到目标血管超声图像以提高图像质量;其中,所述目标亮度映射参数是基于与所述超声信号相同的采样条件下采集的多组样本超声信号在预设超空间中分析确定的参数。本实施例的技术方案解决了相关技术中对血管内超声图 像的动态显示范围进行调整时,图像处理效果不稳定的问题,可以实现在高实时性的血管内超声成像过程中,高效且稳定的调节血管超声图像的动态范围,提高血管图像质量。The technical solution of this embodiment is to obtain an initial vascular ultrasound image based on the ultrasound signal after acquiring the ultrasound signal of the target vascular object; then determine the target brightness mapping parameters that match the ultrasound signal; and adjust the brightness of the initial vascular ultrasound image based on the target brightness mapping parameters to obtain the target vascular ultrasound image to improve the image quality; wherein the target brightness mapping parameters are parameters determined by analyzing multiple groups of sample ultrasound signals collected under the same sampling conditions as the ultrasound signal in a preset hyperspace. The technical solution of this embodiment solves the problem of intravascular ultrasound image in the related art. The problem of unstable image processing effect when the dynamic display range of the image is adjusted can be solved by efficiently and stably adjusting the dynamic range of the vascular ultrasound image during high real-time intravascular ultrasound imaging to improve the quality of the vascular image.
图2为本申请实施例提供的一种血管超声图像处理方法的流程图,本实施例与上述实施例中的血管超声图像处理方法属于同一个发明构思,进一步的描述了目标亮度映射参数的确定过程。该方法可以由血管超声图像处理装置执行,该装置可以由软件和/或硬件的方式来实现,集成于具有应用开发功能的计算机设备中。FIG2 is a flow chart of a vascular ultrasound image processing method provided in an embodiment of the present application. This embodiment and the vascular ultrasound image processing method in the above embodiment belong to the same inventive concept, and further describes the determination process of the target brightness mapping parameter. The method can be executed by a vascular ultrasound image processing device, which can be implemented by software and/or hardware and integrated into a computer device with application development function.
如图2所示,本实施例的血管超声图像处理方法包括以下步骤:As shown in FIG2 , the blood vessel ultrasound image processing method of this embodiment includes the following steps:
S210、获取目标信号采集器件采集到的多组样本超声信号,分别对所述多组样本超声信号进行信号预处理,得到对应的空间频率信号图。S210 , acquiring multiple groups of sample ultrasonic signals collected by the target signal collection device, and performing signal preprocessing on the multiple groups of sample ultrasonic signals respectively to obtain corresponding spatial frequency signal graphs.
目标信号采集器件可以是任一种型号的用于血管内超声成像且需要进行更适配的亮度映射参数探索的器件,如能够实现超声信号转换、发射以及接收的超声换能器。这是由于不同的器件对应的超声信号转换以及信号采集能力是不同的,因此需要为每一个不同型号的信号采集器件确定一个与其更加适配的亮度映射参数。可选地,确定每个不同型号的信号采集器件适配的亮度映射参数,可以通过对每个信号采集器件针对目标血管对象采集的大量的样本超声信号进行分析来实现。The target signal acquisition device can be any type of device used for intravascular ultrasound imaging and that requires exploration of more suitable brightness mapping parameters, such as an ultrasonic transducer that can realize ultrasound signal conversion, transmission, and reception. This is because different devices have different corresponding ultrasound signal conversion and signal acquisition capabilities, so it is necessary to determine a brightness mapping parameter that is more suitable for each different type of signal acquisition device. Optionally, determining the brightness mapping parameters that are suitable for each different type of signal acquisition device can be achieved by analyzing a large number of sample ultrasound signals collected by each signal acquisition device for the target vascular object.
本实施例中,分别对多组样本超声信号进行信号预处理,得到对应的空间频率信号图的过程可以包括如下步骤:In this embodiment, the process of performing signal preprocessing on multiple groups of sample ultrasonic signals to obtain corresponding spatial frequency signal graphs may include the following steps:
首先,针对所述多组样本超声信号中在每一个采样角度的信号,进行同步压缩小波变换,得到所述多组样本超声信号在每一个采样角度对应的信号时频图。First, synchronous compression wavelet transform is performed on the signals at each sampling angle in the multiple groups of sample ultrasonic signals to obtain the signal time-frequency diagrams corresponding to each sampling angle in the multiple groups of sample ultrasonic signals.
基于血管超声信号采集的形式和特征,超声信号通常是以极坐标数据进行表示的。那么,每一组样本超声信号中,在极坐标系下每一个角度都对应一个时间信号序列。在本实施例中,以角度为维度,对每个角度的样本超声信号进行同步的压缩小波变换,以构建多个不同频率的超声信号对应的通道,通常通道数会设置为3-5个,从而得到样本超声信号的每一个采样角度对应的信号时频图,是一个以时间-频率-信号强度值确定的三维图。 Based on the form and characteristics of vascular ultrasound signal acquisition, ultrasound signals are usually represented by polar coordinate data. Then, in each group of sample ultrasound signals, each angle in the polar coordinate system corresponds to a time signal sequence. In this embodiment, with the angle as the dimension, the sample ultrasound signal of each angle is synchronously compressed by wavelet transform to construct channels corresponding to multiple ultrasound signals of different frequencies. Usually, the number of channels is set to 3-5, so as to obtain the signal time-frequency diagram corresponding to each sampling angle of the sample ultrasound signal, which is a three-dimensional diagram determined by time-frequency-signal intensity value.
然后,将多个采样角度对应的信号时频图进行组合,得到三维栅格形式的空间频率信号图。即将不同角度的信号时频图叠加显示在一个空间内,形成了一个四维的数据图。Then, the signal time-frequency diagrams corresponding to multiple sampling angles are combined to obtain a spatial frequency signal diagram in the form of a three-dimensional grid, that is, the signal time-frequency diagrams at different angles are superimposed and displayed in one space to form a four-dimensional data diagram.
S220、识别所述空间频率信号图中的不同血管组织,并统计每个血管组织的多个预设信号分析维度的数据。S220 , identifying different vascular tissues in the spatial frequency signal image, and counting data of multiple preset signal analysis dimensions for each vascular tissue.
在空间频率信号图中识别不同血管组织时,可以通过神经网络图像识别的方式,例如可以识别不同的血管成分,如血液、组织、纤维斑块、钙化斑块及支架等组织成分。预先对多个空间频率信号图中的不同血管组织进行标记,训练一个能够识别不同血管组织成分的神经网络模型,将空间频率信号图输入到该神经网络模型中,得到对应的不同血管组织成分的识别结果。在空间频率信号图中识别不同血管组织时,也可以采用人工标注,或者其他可以实现血管组织成分识别的方式。When different vascular tissues are identified in the spatial frequency signal graph, neural network image recognition can be used, for example, different vascular components can be identified, such as blood, tissue, fibrous plaque, calcified plaque, stent and other tissue components. Different vascular tissues in multiple spatial frequency signal graphs are marked in advance, a neural network model that can identify different vascular tissue components is trained, and the spatial frequency signal graph is input into the neural network model to obtain the corresponding recognition results of different vascular tissue components. When different vascular tissues are identified in the spatial frequency signal graph, manual labeling or other methods that can realize vascular tissue component identification can also be used.
基于不同血管组织的识别结果,可以进一步分析不同数据对应的多个预设信号分析维度的数据,如空间频率信号图中识别不同血管组织成分对应数据点信号强度值、信号强度均值、信号强度方差以及每个血管组织所在区域的纹理描述参数。其中,纹理描述参数可以是灰度共生矩阵、同质纹理描述符及边缘直方图描述符中的至少一个参数。Based on the recognition results of different vascular tissues, data of multiple preset signal analysis dimensions corresponding to different data can be further analyzed, such as the signal intensity value, signal intensity mean, signal intensity variance of data points corresponding to different vascular tissue components in the spatial frequency signal map, and texture description parameters of the area where each vascular tissue is located. The texture description parameter can be at least one parameter of a gray level co-occurrence matrix, a homogeneous texture descriptor, and an edge histogram descriptor.
S230、基于每个血管组织的所述多个预设信号分析维度的数据,在所述多个预设信号分析维度构成的超空间中分析确定所述目标亮度映射参数。S230 . Based on the data of the multiple preset signal analysis dimensions of each vascular tissue, analyze and determine the target brightness mapping parameters in a hyperspace formed by the multiple preset signal analysis dimensions.
首先,可以以多个预设信号分析维度建立一个超空间,然后,基于每个血管组织的多个预设信号分析维度的数据确定每个血管组织在所述超空间的分布区域。一个空间频率信号图中的一个血管组织成分可以在超空间中对应一点,多个样本超声信号处理后得到的多个空间频率信号图中同类别的血管组织成分在超空间中对应多个点,可以构成一个点云。First, a hyperspace can be established with multiple preset signal analysis dimensions, and then the distribution area of each vascular tissue in the hyperspace can be determined based on the data of the multiple preset signal analysis dimensions of each vascular tissue. A vascular tissue component in a spatial frequency signal graph can correspond to a point in the hyperspace, and vascular tissue components of the same category in multiple spatial frequency signal graphs obtained after processing multiple sample ultrasound signals correspond to multiple points in the hyperspace, which can form a point cloud.
进而,调节初始血管超声图像对应的亮度映射曲线数值(即初始亮度映射曲线值),每调节一次亮度映射曲线的数值,计算一次不同类别的血管组织成分构成的点云的中心之间的距离。Then, the brightness mapping curve value corresponding to the initial vascular ultrasound image (ie, the initial brightness mapping curve value) is adjusted, and each time the brightness mapping curve value is adjusted, the distance between the centers of the point clouds composed of different types of vascular tissue components is calculated.
最终,将使多个血管组织的分布区域的中心点之间的距离为最大距离值的亮度映射曲线数值确定为所述目标亮度映射参数。即可以理解为找到一组目标 亮度曲线映射参数,可以使不同类别的血管组织成分构成的点云的中心之间的距离最大,即使不同类别的血管组织成分有更好的区分度。Finally, the brightness mapping curve value that makes the distance between the center points of the distribution areas of the multiple vascular tissues the maximum distance value is determined as the target brightness mapping parameter. The brightness curve mapping parameters can maximize the distance between the centers of the point clouds composed of different categories of vascular tissue components, that is, the different categories of vascular tissue components have better distinction.
距离的计算可以采用欧式距离或者其他的距离计算规则实现,也可以是采用人工智能图像识别的方式计算确定。The distance calculation may be implemented by using Euclidean distance or other distance calculation rules, or may be calculated and determined by using artificial intelligence image recognition.
目标亮度映射参数确定以后,便可以应用在对相关血管内超声图像进行处理的过程中。Once the target brightness mapping parameters are determined, they can be applied in the process of processing relevant intravascular ultrasound images.
S240、在获取到基于所述目标信号采集器件采集的目标血管对象的待处理超声信号的情况下,基于所述待处理超声信号得到初始血管超声图像。S240. When an ultrasonic signal to be processed of a target blood vessel object acquired by the target signal acquisition device is acquired, an initial blood vessel ultrasonic image is obtained based on the ultrasonic signal to be processed.
S250、基于所述目标亮度映射参数对所述初始血管超声图像的亮度进行调整,得到目标血管超声图像。S250: Adjust the brightness of the initial vascular ultrasound image based on the target brightness mapping parameter to obtain a target vascular ultrasound image.
本实施例的技术方案,通过先使用目标信号采集器件进行大量超声信号采样,采集得到多组样本超声信号并分别对所述多组样本超声信号进行信号预处理,得到对应的空间频率信号图;进而识别所述空间频率信号图中的不同血管组织,并统计每个血管组织的多个预设信号分析维度的数据;以基于每个血管组织的所述多个预设信号分析维度的数据,在所述多个预设信号分析维度构成的超空间中分析确定所述目标亮度映射参数。以便在获取到目标信号采集器件对目标血管对象进行成像的超声信号之后,基于所述超声信号得到初始血管超声图像;然后确定与采集所述超声信号的信号采集器件匹配的目标亮度映射参数;并基于所述目标亮度映射参数对所述初始血管超声图像的亮度进行调整,得到目标血管超声图像以提高图像质量;其中,所述目标亮度映射参数是基于所述信号采集器件采集的多组样本超声信号在预设超空间中分析确定的参数。本实施例的技术方案解决了相关技术中对血管内超声图像的动态显示范围进行调整时,图像处理效果不稳定的问题,可以实现在高实时性的血管内超声成像过程中,高效且稳定的调节血管超声图像的动态范围,提高血管图像质量。The technical solution of this embodiment is to first use the target signal acquisition device to perform a large number of ultrasonic signal sampling, collect multiple groups of sample ultrasonic signals, and perform signal preprocessing on the multiple groups of sample ultrasonic signals respectively to obtain the corresponding spatial frequency signal map; then identify different vascular tissues in the spatial frequency signal map, and count the data of multiple preset signal analysis dimensions of each vascular tissue; based on the data of the multiple preset signal analysis dimensions of each vascular tissue, analyze and determine the target brightness mapping parameters in the hyperspace formed by the multiple preset signal analysis dimensions. So that after the ultrasonic signal of the target signal acquisition device imaging the target vascular object is obtained, an initial vascular ultrasonic image is obtained based on the ultrasonic signal; then determine the target brightness mapping parameters that match the signal acquisition device that collects the ultrasonic signal; and adjust the brightness of the initial vascular ultrasonic image based on the target brightness mapping parameters to obtain the target vascular ultrasonic image to improve the image quality; wherein the target brightness mapping parameters are parameters determined based on the analysis of the multiple groups of sample ultrasonic signals collected by the signal acquisition device in the preset hyperspace. The technical solution of this embodiment solves the problem of unstable image processing effect when adjusting the dynamic display range of intravascular ultrasound images in the related technology. It can achieve efficient and stable adjustment of the dynamic range of vascular ultrasound images in the highly real-time intravascular ultrasound imaging process, thereby improving the quality of vascular images.
图3为本申请实施例提供的一种血管超声图像处理装置的结构示意图,本实施例可适用于基于血管内超声信号进行信号处理得到血管超声图像的场景,该装置可以由软件和/或硬件的方式来实现,集成于具有应用开发功能的计算机终端设备中。Figure 3 is a structural schematic diagram of a vascular ultrasound image processing device provided in an embodiment of the present application. This embodiment can be applied to a scenario in which a vascular ultrasound image is obtained by performing signal processing based on an intravascular ultrasound signal. The device can be implemented by software and/or hardware and integrated into a computer terminal device with application development capabilities.
如图3所示,血管超声图像处理装置包括:图像生成模块310、图像处理参 数获取模块320和图像处理模块330。As shown in FIG3 , the blood vessel ultrasound image processing device includes: an image generation module 310, an image processing parameter A data acquisition module 320 and an image processing module 330.
图像生成模块310,设置为获取目标血管对象的超声信号,并基于所述超声信号得到初始血管超声图像;图像处理参数获取模块320,设置为确定与所述超声信号匹配的目标亮度映射参数;图像处理模块330,设置为基于所述目标亮度映射参数对所述初始血管超声图像的亮度进行调整,得到目标血管超声图像;其中,所述目标亮度映射参数是基于与所述超声信号相同的采样条件下采集的多组样本超声信号在预设超空间中分析确定的参数。The image generation module 310 is configured to acquire an ultrasonic signal of a target vascular object and obtain an initial vascular ultrasonic image based on the ultrasonic signal; the image processing parameter acquisition module 320 is configured to determine a target brightness mapping parameter that matches the ultrasonic signal; the image processing module 330 is configured to adjust the brightness of the initial vascular ultrasonic image based on the target brightness mapping parameter to obtain a target vascular ultrasonic image; wherein the target brightness mapping parameter is a parameter determined by analyzing multiple groups of sample ultrasonic signals collected under the same sampling conditions as the ultrasonic signal in a preset hyperspace.
本实施例的技术方案,通过在获取目标血管对象的超声信号之后,基于所述超声信号得到初始血管超声图像;然后确定与所述超声信号匹配的目标亮度映射参数;并基于所述目标亮度映射参数对所述初始血管超声图像的亮度进行调整,得到目标血管超声图像以提高图像质量;其中,所述目标亮度映射参数是基于与所述超声信号相同的采样条件下采集的多组样本超声信号在预设超空间中分析确定的参数。本实施例的技术方案解决了相关技术中对血管内超声图像的动态显示范围进行调整时,图像处理效果不稳定的问题,可以实现在高实时性的血管内超声成像过程中,高效且稳定的调节血管超声图像的动态范围,提高血管图像质量。The technical solution of this embodiment is to obtain an initial vascular ultrasound image based on the ultrasound signal after acquiring the ultrasound signal of the target vascular object; then determine the target brightness mapping parameters that match the ultrasound signal; and adjust the brightness of the initial vascular ultrasound image based on the target brightness mapping parameters to obtain the target vascular ultrasound image to improve the image quality; wherein the target brightness mapping parameters are parameters determined by analyzing multiple groups of sample ultrasound signals collected under the same sampling conditions as the ultrasound signal in a preset hyperspace. The technical solution of this embodiment solves the problem of unstable image processing effect when adjusting the dynamic display range of intravascular ultrasound images in related technologies, and can achieve efficient and stable adjustment of the dynamic range of vascular ultrasound images in a highly real-time intravascular ultrasound imaging process to improve the quality of vascular images.
可选的,血管超声图像处理装置还包括参数分析模块,设置为基于与所述超声信号相同的采样条件下采集的多组样本超声信号在预设超空间中分析确定所述目标亮度映射参数;Optionally, the vascular ultrasound image processing device further includes a parameter analysis module configured to analyze and determine the target brightness mapping parameters in a preset hyperspace based on a plurality of groups of sample ultrasound signals acquired under the same sampling conditions as the ultrasound signal;
所述参数分析模块是设置为:The parameter analysis module is set to:
分别对所述多组样本超声信号进行信号预处理,得到对应的空间频率信号图;Performing signal preprocessing on the multiple groups of sample ultrasonic signals respectively to obtain corresponding spatial frequency signal graphs;
识别所述空间频率信号图中的不同血管组织,并统计每个血管组织的多个预设信号分析维度的数据;Identifying different vascular tissues in the spatial frequency signal map, and counting data of multiple preset signal analysis dimensions for each vascular tissue;
基于每个血管组织的所述多个预设信号分析维度的数据,在所述多个预设信号分析维度构成的超空间中分析确定所述目标亮度映射参数。Based on the data of the multiple preset signal analysis dimensions of each vascular tissue, the target brightness mapping parameters are analyzed and determined in a hyperspace formed by the multiple preset signal analysis dimensions.
可选的,所述参数分析模块是设置为:Optionally, the parameter analysis module is set to:
针对所述多组样本超声信号中在每一个采样角度的信号,进行同步压缩小波变换,得到所述多组样本超声信号在每一个采样角度对应的信号时频图; Performing synchronous compression wavelet transform on the signals at each sampling angle in the multiple groups of sample ultrasonic signals to obtain a signal time-frequency diagram corresponding to each sampling angle in the multiple groups of sample ultrasonic signals;
将多个采样角度对应的信号时频图进行组合,得到三维栅格形式的空间频率信号图。The signal time-frequency diagrams corresponding to multiple sampling angles are combined to obtain a spatial frequency signal diagram in the form of a three-dimensional grid.
可选的,所述参数分析模块是设置为:Optionally, the parameter analysis module is set to:
分别统计所述血管组织对应的信号强度值、信号强度均值、信号强度方差以及每个血管组织所在区域的纹理描述参数。The signal strength value, signal strength mean, signal strength variance corresponding to the vascular tissue and the texture description parameters of the region where each vascular tissue is located are respectively counted.
可选的,所述参数分析模块是设置为:Optionally, the parameter analysis module is set to:
基于每个血管组织的所述多个预设信号分析维度的数据确定每个血管组织在所述超空间的分布区域;Determine the distribution area of each vascular tissue in the hyperspace based on the data of the multiple preset signal analysis dimensions of each vascular tissue;
调节所述初始血管超声图像对应的亮度映射曲线数值,将使多个血管组织的分布区域的中心点之间的距离为最大距离值的亮度映射曲线数值确定为所述目标亮度映射参数。The brightness mapping curve value corresponding to the initial blood vessel ultrasonic image is adjusted, and the brightness mapping curve value that makes the distance between the center points of the distribution areas of the plurality of blood vessel tissues the maximum distance value is determined as the target brightness mapping parameter.
可选的,图像生成模块310是设置为:Optionally, the image generation module 310 is configured to:
将所述超声信号分别输入到多个不同滤波频段的预设带通滤波器,得到对应频段的超声滤波信号;Inputting the ultrasonic signal into a plurality of preset bandpass filters of different filtering frequency bands respectively to obtain ultrasonic filtering signals of corresponding frequency bands;
分别对多个所述超声滤波信号进行时间增益补偿,并将补偿后的信号进行叠加,得到处理后超声信号;Performing time gain compensation on the plurality of ultrasonic filter signals respectively, and superimposing the compensated signals to obtain processed ultrasonic signals;
根据所述处理后超声信号得到所述初始血管超声图像。The initial blood vessel ultrasonic image is obtained according to the processed ultrasonic signal.
可选的,所述超声信号由信号采集器件采集得到,图像处理参数获取模块320是设置为:Optionally, the ultrasonic signal is acquired by a signal acquisition device, and the image processing parameter acquisition module 320 is set to:
根据所述信号采集器件的设备参数查询预设亮度映射参数表,得到所述目标亮度映射参数。The preset brightness mapping parameter table is queried according to the device parameters of the signal acquisition device to obtain the target brightness mapping parameters.
本申请实施例所提供的血管超声图像处理装置可执行本申请任意实施例所提供的血管超声图像处理方法,具备执行方法相应的功能模块和效果。The vascular ultrasonic image processing device provided in the embodiment of the present application can execute the vascular ultrasonic image processing method provided in any embodiment of the present application, and has the corresponding functional modules and effects of the execution method.
图4为本申请实施例提供的一种计算机设备的结构示意图。图4示出了适于用来实现本申请实施方式的示例性计算机设备12的框图。图4显示的计算机设备12仅仅是一个示例,不应对本申请实施例的功能和使用范围带来任何限制。计算机设备12可以任意具有计算能力的终端设备,如智能控制器及服务器、手机等终端设备。 FIG4 is a schematic diagram of the structure of a computer device provided in an embodiment of the present application. FIG4 shows a block diagram of an exemplary computer device 12 suitable for implementing the implementation of the present application. The computer device 12 shown in FIG4 is only an example and should not bring any limitation to the functions and scope of use of the embodiment of the present application. The computer device 12 can be any terminal device with computing capabilities, such as intelligent controllers and servers, mobile phones and other terminal devices.
如图4所示,计算机设备12以通用计算设备的形式表现。计算机设备12的组件可以包括但不限于:一个或者多个处理器或者处理单元16,系统存储器28,连接不同系统组件(包括系统存储器28和处理单元16)的总线18。4, computer device 12 is in the form of a general purpose computing device. Components of computer device 12 may include, but are not limited to, one or more processors or processing units 16, system memory 28, and bus 18 connecting various system components (including system memory 28 and processing unit 16).
总线18表示几类总线结构中的一种或多种,包括存储器总线或者存储器控制器,外围总线,图形加速端口,处理器或者使用多种总线结构中的任意总线结构的局域总线。举例来说,这些体系结构包括但不限于工业标准体系结构(Instruction Set Architecture,ISA)总线,微通道体系结构(Micro Channel Architecture,MAC)总线,增强型ISA总线、视频电子标准协会(Video Electronics Standards Association,VESA)局域总线以及外围组件互连(Peripheral Component Interconnect,PCI)总线。Bus 18 represents one or more of several types of bus structures, including a memory bus or memory controller, a peripheral bus, an accelerated graphics port, a processor, or a local bus using any of a variety of bus structures. For example, these architectures include, but are not limited to, an Instruction Set Architecture (ISA) bus, a Micro Channel Architecture (MAC) bus, an enhanced ISA bus, a Video Electronics Standards Association (VESA) local bus, and a Peripheral Component Interconnect (PCI) bus.
计算机设备12典型地包括多种计算机系统可读介质。这些介质可以是任何能够被计算机设备12访问的可用介质,包括易失性和非易失性介质,可移动的和不可移动的介质。The computer device 12 typically includes a variety of computer system readable media. These media can be any available media that can be accessed by the computer device 12, including volatile and non-volatile media, removable and non-removable media.
系统存储器28可以包括易失性存储器形式的计算机系统可读介质,例如随机存取存储器(Random Access Memory,RAM)30和/或高速缓存存储器32。计算机设备12可以进一步包括其它可移动/不可移动的、易失性/非易失性计算机系统存储介质。仅作为举例,存储系统34可以用于读写不可移动的、非易失性磁介质(图4未显示,通常称为“硬盘驱动器”)。尽管图4中未示出,可以提供用于对可移动非易失性磁盘(例如“软盘”)读写的磁盘驱动器,以及对可移动非易失性光盘,(例如只读存储器(Compact Disc Read-Only Memory,CD-ROM),数字视盘(Digital Video Disc-Read Only Memory,DVD-ROM)或者其它光介质),进行读写的光盘驱动器。在这些情况下,每个驱动器可以通过一个或者多个数据介质接口与总线18相连。系统存储器28可以包括至少一个程序产品,该程序产品具有一组(例如至少一个)程序模块,这些程序模块被配置以执行本申请多个实施例的功能。The system memory 28 may include computer system readable media in the form of volatile memory, such as random access memory (RAM) 30 and/or cache memory 32. The computer device 12 may further include other removable/non-removable, volatile/non-volatile computer system storage media. By way of example only, the storage system 34 may be used to read and write non-removable, non-volatile magnetic media (not shown in FIG. 4 , commonly referred to as a “hard drive”). Although not shown in FIG. 4 , a disk drive for reading and writing removable non-volatile disks (such as “floppy disks”) and an optical disk drive for reading and writing removable non-volatile optical disks (such as read-only memories (Compact Disc Read-Only Memory, CD-ROM), digital video disks (Digital Video Disc-Read Only Memory, DVD-ROM) or other optical media) may be provided. In these cases, each drive may be connected to the bus 18 via one or more data media interfaces. The system memory 28 may include at least one program product having a set (eg, at least one) of program modules. The program modules are configured to perform the functions of various embodiments of the present application.
具有一组(至少一个)程序模块42的程序/实用工具40,可以存储在例如系统存储器28中,这样的程序模块42包括但不限于操作系统、一个或者多个应用程序、其它程序模块以及程序数据,这些示例中的每一个或某种组合中可能包括网络环境的实现。程序模块42通常执行本申请所描述的实施例中的功能和/或方法。 A program/utility 40 having a set (at least one) of program modules 42 may be stored, for example, in system memory 28, such program modules 42 including, but not limited to, an operating system, one or more application programs, other program modules, and program data, each of which or some combination may include an implementation of a network environment. Program modules 42 generally perform the functions and/or methods of the embodiments described herein.
计算机设备12也可以与一个或多个外部设备14(例如键盘、指向设备、显示器24等)通信,还可与一个或者多个使得用户能与该计算机设备12交互的设备通信,和/或与使得该计算机设备12能与一个或多个其它计算设备进行通信的任何设备(例如网卡,调制解调器等等)通信。这种通信可以通过输入/输出(Input/Output,I/O)接口22进行。并且,计算机设备12还可以通过网络适配器20与一个或者多个网络通信,例如局域网(Local Area Network,LAN),广域网(Wide Area Network,WAN)和/或公共网络(例如因特网)。如图4所示,网络适配器20通过总线18与计算机设备12的其它模块通信。应当明白,尽管图4中未示出,可以结合计算机设备12使用其它硬件和/或软件模块,包括但不限于:微代码、设备驱动器、冗余处理单元、外部磁盘驱动阵列、独立磁盘冗余阵列(Redundant Arrays of Independent Disks,RAID)系统、磁带驱动器以及数据备份存储系统等。The computer device 12 may also communicate with one or more external devices 14 (e.g., keyboard, pointing device, display 24, etc.), one or more devices that enable a user to interact with the computer device 12, and/or any device that enables the computer device 12 to communicate with one or more other computing devices (e.g., network card, modem, etc.). Such communication may be performed through an input/output (I/O) interface 22. In addition, the computer device 12 may also communicate with one or more networks, such as a local area network (LAN), a wide area network (WAN), and/or a public network (e.g., the Internet) through a network adapter 20. As shown in FIG. 4 , the network adapter 20 communicates with other modules of the computer device 12 through a bus 18. It should be understood that although not shown in Figure 4, other hardware and/or software modules may be used in conjunction with the computer device 12, including but not limited to: microcode, device drivers, redundant processing units, external disk drive arrays, redundant arrays of independent disks (Redundant Arrays of Independent Disks, RAID) systems, tape drives, and data backup storage systems.
处理单元16通过运行存储在系统存储器28中的程序,从而执行多种功能应用以及数据处理,例如实现本发实施例所提供的血管超声图像处理方法,该方法包括:The processing unit 16 executes a variety of functional applications and data processing by running the program stored in the system memory 28, for example, implementing the vascular ultrasound image processing method provided by the embodiment of the present invention, the method comprising:
获取目标血管对象的超声信号,并基于所述超声信号得到初始血管超声图像;Acquire an ultrasonic signal of a target blood vessel object, and obtain an initial blood vessel ultrasonic image based on the ultrasonic signal;
确定与所述超声信号匹配的目标亮度映射参数;其中,所述目标亮度映射参数是基于与所述超声信号相同的采样条件下采集的多组样本超声信号在预设超空间中分析确定的参数;Determine a target brightness mapping parameter that matches the ultrasonic signal; wherein the target brightness mapping parameter is a parameter determined by analyzing multiple groups of sample ultrasonic signals collected under the same sampling conditions as the ultrasonic signal in a preset hyperspace;
基于所述目标亮度映射参数对所述初始血管超声图像的亮度进行调整,得到目标血管超声图像。The brightness of the initial blood vessel ultrasonic image is adjusted based on the target brightness mapping parameter to obtain a target blood vessel ultrasonic image.
本申请实施例还提供了一种计算机可读存储介质,其上存储有计算机程序,该程序被处理器执行时实现如本申请任意实施例所提供的血管超声图像处理方法,该方法包括:The present application also provides a computer-readable storage medium on which a computer program is stored. When the program is executed by a processor, the method for processing a vascular ultrasound image provided in any embodiment of the present application is implemented. The method includes:
获取目标血管对象的超声信号,并基于所述超声信号得到初始血管超声图像;Acquire an ultrasonic signal of a target blood vessel object, and obtain an initial blood vessel ultrasonic image based on the ultrasonic signal;
确定与所述超声信号匹配的目标亮度映射参数;其中,所述目标亮度映射参数是基于与所述超声信号相同的采样条件下采集的多组样本超声信号在预设 超空间中分析确定的参数;Determine a target brightness mapping parameter that matches the ultrasonic signal; wherein the target brightness mapping parameter is based on a plurality of groups of sample ultrasonic signals collected under the same sampling conditions as the ultrasonic signal in a preset Parameters determined by analysis in hyperspace;
基于所述目标亮度映射参数对所述初始血管超声图像的亮度进行调整,得到目标血管超声图像。The brightness of the initial blood vessel ultrasonic image is adjusted based on the target brightness mapping parameter to obtain a target blood vessel ultrasonic image.
本申请实施例的计算机存储介质,可以采用一个或多个计算机可读的介质的任意组合。计算机可读介质可以是计算机可读信号介质或者计算机可读存储介质。计算机可读存储介质例如可以是但不限于:电、磁、光、电磁、红外线、或半导体的系统、装置或器件,或者任意以上的组合。计算机可读存储介质的更具体的例子(非穷举的列表)包括:具有一个或多个导线的电连接、便携式计算机磁盘、硬盘、RAM、ROM、可擦式可编程只读存储器(Erasable Programmable Read Only Memory,EPROM)或闪存、光纤、CD-ROM、光存储器件、磁存储器件、或者上述的任意合适的组合。在本文件中,计算机可读存储介质可以是任何包含或存储程序的有形介质,该程序可以被指令执行系统、装置或者器件使用或者与其结合使用。The computer storage medium of the embodiment of the present application may adopt any combination of one or more computer-readable media. The computer-readable medium may be a computer-readable signal medium or a computer-readable storage medium. The computer-readable storage medium may be, for example, but not limited to: an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, device or device, or any combination of the above. More specific examples of computer-readable storage media (a non-exhaustive list) include: an electrical connection with one or more wires, a portable computer disk, a hard disk, RAM, ROM, an erasable programmable read-only memory (EPROM) or flash memory, optical fiber, CD-ROM, an optical storage device, a magnetic storage device, or any suitable combination of the above. In this document, a computer-readable storage medium may be any tangible medium containing or storing a program that can be used by or in conjunction with an instruction execution system, device or device.
计算机可读的信号介质可以包括在基带中或者作为载波一部分传播的数据信号,其中承载了计算机可读的程序代码。这种传播的数据信号可以采用多种形式,包括但不限于电磁信号、光信号或上述的任意合适的组合。计算机可读的信号介质还可以是计算机可读存储介质以外的任何计算机可读介质,该计算机可读介质可以发送、传播或者传输用于由指令执行系统、装置或者器件使用或者与其结合使用的程序。Computer-readable signal media may include data signals propagated in baseband or as part of a carrier wave, which carry computer-readable program code. Such propagated data signals may take a variety of forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination of the above. Computer-readable signal media may also be any computer-readable medium other than a computer-readable storage medium, which may send, propagate, or transmit a program for use by or in conjunction with an instruction execution system, apparatus, or device.
计算机可读介质上包含的程序代码可以用任何适当的介质传输,包括但不限于:无线、电线、光缆、射频(Radio Frequency,RF)等等,或者上述的任意合适的组合。The program code contained on the computer-readable medium can be transmitted using any appropriate medium, including but not limited to: wireless, wire, optical cable, radio frequency (RF), etc., or any suitable combination of the above.
可以以一种或多种程序设计语言或其组合来编写用于执行本申请操作的计算机程序代码,所述程序设计语言包括面向对象的程序设计语言,诸如Java、Smalltalk、C++,还包括常规的过程式程序设计语言,诸如“C”语言或类似的程序设计语言。程序代码可以完全地在用户计算机上执行、部分地在用户计算机上执行、作为一个独立的软件包执行、部分在用户计算机上部分在远程计算机上执行、或者完全在远程计算机或服务器上执行。在涉及远程计算机的情形中,远程计算机可以通过任意种类的网络,包括LAN或WAN,连接到用户计算 机,或者,可以连接到外部计算机(例如利用因特网服务提供商来通过因特网连接)。The computer program code for performing the operations of the present application may be written in one or more programming languages or a combination thereof, including object-oriented programming languages such as Java, Smalltalk, C++, and conventional procedural programming languages such as "C" or similar programming languages. The program code may be executed entirely on the user's computer, partially on the user's computer, as a separate software package, partially on the user's computer and partially on a remote computer, or entirely on a remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer via any type of network, including a LAN or WAN. Alternatively, it can be connected to an external computer (for example, through the Internet using an Internet service provider).
上述的本申请的多个模块或多个步骤可以用通用的计算装置来实现,它们可以集中在单个计算装置上,或者分布在多个计算装置所组成的网络上,可选地,他们可以用计算机装置可执行的程序代码来实现,从而可以将它们存储在存储装置中由计算装置来执行,或者将它们分别制作成多个集成电路模块,或者将它们中的多个模块或步骤制作成单个集成电路模块来实现。这样,本申请不限制于任何特定的硬件和软件的结合。 The above-mentioned multiple modules or multiple steps of the present application can be implemented by a general-purpose computing device, they can be concentrated on a single computing device, or distributed on a network composed of multiple computing devices, optionally, they can be implemented by a program code executable by a computer device, so that they can be stored in a storage device and executed by the computing device, or they can be made into multiple integrated circuit modules respectively, or multiple modules or steps therein can be made into a single integrated circuit module for implementation. Thus, the present application is not limited to any specific combination of hardware and software.
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| US12354755B2 (en) | 2012-10-24 | 2025-07-08 | Cathworks Ltd | Creating a vascular tree model |
| US12446965B2 (en) | 2023-08-09 | 2025-10-21 | Cathworks Ltd. | Enhanced user interface and crosstalk analysis for vascular index measurement |
| US12499646B1 (en) | 2024-06-12 | 2025-12-16 | Cathworks Ltd. | Three-dimensional sizing tool for cardiac assessment |
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| CN119791719A (en) * | 2023-10-10 | 2025-04-11 | 上海博动医疗科技股份有限公司 | Intravascular image generation method, device, equipment and medium |
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