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WO2024226032A1 - Conditions thermodynamiques pour l'extraction de spectres précis de psilocybine et d'alcaloïdes associés - Google Patents

Conditions thermodynamiques pour l'extraction de spectres précis de psilocybine et d'alcaloïdes associés Download PDF

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Publication number
WO2024226032A1
WO2024226032A1 PCT/US2023/019689 US2023019689W WO2024226032A1 WO 2024226032 A1 WO2024226032 A1 WO 2024226032A1 US 2023019689 W US2023019689 W US 2023019689W WO 2024226032 A1 WO2024226032 A1 WO 2024226032A1
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WO
WIPO (PCT)
Prior art keywords
soven
weren
orr
cam
meo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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PCT/US2023/019689
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English (en)
Inventor
Anne Christine BRADDOCK
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Individual
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Individual
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Priority to PCT/US2023/019689 priority Critical patent/WO2024226032A1/fr
Publication of WO2024226032A1 publication Critical patent/WO2024226032A1/fr
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/078—Psilocybe
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0203—Solvent extraction of solids with a supercritical fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0292—Treatment of the solvent
    • B01D11/0296—Condensation of solvent vapours
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0004—Crystallisation cooling by heat exchange
    • B01D9/0013—Crystallisation cooling by heat exchange by indirect heat exchange
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D2011/007—Extraction using a solvent in the gas phase

Definitions

  • s oen comouns asoaucn anurae or oan csomounsrom an oransmne reave raos o e wc are naura mecnes or oramn.smsss oene case,ornsance,or oransms reave raos oaree comounsn a warcueasrra oreanssmc woacveroeres.
  • an usn sronerosesn en oe socn can causeerano creae n wew nn.n amazn
  • sues sowa ermanen saes o enancera eura newors,ncana can creae narrave oeasascen acv.s new researcsn sar conrasoe eecs
  • suc as c ecrusac an reeemn uses anave sron neave musroomccso"r renaus erson o mer useaxn rocooam mrsaae.
  • eocaec m aomen,oarza ane arcuar wen comex comouns a n eecveness o a soven,usrecors.e renvoveese caracerscs areusa,.e., comeerecameca evenneravcenonse, s cuucrre ans aeva snocueo sna oe c oom comexu ceomouns, are no e w rearsoe exracon oscoacve aaos wasre moen.ss e raos oescoacve comouns exrace canav sue canesn exerence e a maormac one o eroermuce nesne exrac.
  • ecs ans an ovaneca oes oereesernesennvennveonnoon exracn aaosrom oranc maer.
  • rove a meo an aarausor exracns a anaooers oromec o oranec mreaseenr wnvecn monnomzroev see a ex mreo an aarausor m rouce uneasan eecs, suc as acon o comouns wc s anoer oec oeresenn nvaeunsea, wen consume.
  • cononsore exracon oesrceseonacnvvee anoanoosrorovmes oocman merumsoroonmams succa seec orruamn oc sseccruomac ov eex araacoessocunoacnves aocaons m accurae reecse oranc s anoer oec oeresennvenonorovuser aoo mms.
  • nevsen oonerorevsenenvereenno.n we aarenrome reesc seccaoer n a,ccoon um o sraane e enraw moun mres esn, ws oc aerenncororaen anorm aar oeresen aove aneeaeescro venon an,oeer weescronven exanernc n oereerre emomensveneow, serveo uurree ssoe aws scs o aenm ee axen cmven aaron ram s.o ou aox cureve exorra acno araon a soven.
  • erernu raoss ocesecco eaxcevree cnocmes aoruens are sunoewcnvoe,roveren seces,ecause o exerences oern caracer.
  • e caon wseenrencun even m oar sovensere areousans ase soven snce unereroer co.nccoonrs onroessuerer aensenemnveenraounre me cananorosu ucese an e axccroarcn wo aoewr eexsernacn sveencrounm ase srceecnaeeeevowaornov.es anz exnrace srocesses ercenaeevaon o aroun or seces suc as.
  • socn an reaescoacve aaosromsocn musrooe exracon onvenon ma asoe aeoe exracon o oer aaosromms,eresen maeras.urermore, soue noea aoueresennv oer orancerms oe use o meano ase soven, oer soven enonsescren sovenroeres o meano, areoe cons s, suc asose wc mmcensance,eroeres o caronox ere wne scoe oenvenon.or anemeraureo mmce so e a ressure maeune ausnressure scoacve aaos.evenroeres o meanooreurose o exracnnvenon car reore, accorno an aernae
  • aoveoornoeresennvenone acaon oea an vacuum as sece uzero rremeov exar oac soonve onreo amaeorsecromaees oreranorcm meaenra,e o sra cmaen eeuramen as was vacuum ovenore sae o ecencn orero usee exr nserreo a anecause vacuum ovensenoear acor eumenor exraconras.srovese avanae o rer soerecae cane srea ounares a aoxcsrovese a eucnrocessn ses.urermore,e sovenoe soven.
  • vanae o mnmzne exosure orocessnersonne oecus we seenaemrovemensreseneeren are conssen we aoves oescrenovne cnononanosr m maeno se acn aceasr,auesseor s eoxurac noonee csocrnserue a aosve.
  • ee e scoe oenvenon,u raer as exemcaons oreerr maons on an oer varaons are wne scoe oeresennv e emomensereo.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé et un appareil pour l'extraction d'alcaloïdes psychoactifs à partir de matière organique, tels que des champignons contenant de la psilocybine, au moyen d'un solvant. Pour fournir un spectre de composés psychoactifs dans l'extrait représentant avec précision le spectre de composés psychoactifs dans la matière organique, du méthanol est utilisé en tant que solvant. L'extraction est mise en œuvre dans un récipient scellé afin d'isoler le système des conditions environnementales ambiantes (pression, température et humidité). L'extraction est mise en œuvre à une pression d'environ 50 Torr et à une température d'environ 50°C. Le solvant est éliminé du précipité à 50°C à environ 50 Torr, et la température du précipité s'abaisse immédiatement dès que la région où se trouve un point d'inflexion dans la courbe de dégazage par rapport au temps est atteinte.
PCT/US2023/019689 2023-04-24 2023-04-24 Conditions thermodynamiques pour l'extraction de spectres précis de psilocybine et d'alcaloïdes associés Pending WO2024226032A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US2023/019689 WO2024226032A1 (fr) 2023-04-24 2023-04-24 Conditions thermodynamiques pour l'extraction de spectres précis de psilocybine et d'alcaloïdes associés

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2023/019689 WO2024226032A1 (fr) 2023-04-24 2023-04-24 Conditions thermodynamiques pour l'extraction de spectres précis de psilocybine et d'alcaloïdes associés

Publications (1)

Publication Number Publication Date
WO2024226032A1 true WO2024226032A1 (fr) 2024-10-31

Family

ID=93256940

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/019689 Pending WO2024226032A1 (fr) 2023-04-24 2023-04-24 Conditions thermodynamiques pour l'extraction de spectres précis de psilocybine et d'alcaloïdes associés

Country Status (1)

Country Link
WO (1) WO2024226032A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB531224A (en) * 1938-09-24 1940-12-31 Gen Mills Inc Improvements in or relating to processes of producing a vitamin e concentrate and antioxidant from wheat germ oil, and the products resulting therefrom
WO2016053678A1 (fr) * 2014-09-30 2016-04-07 Noramco, Inc. Procédé d'extraction et de concentration d'alcaloïdes au moyen d'oxyde de diméthyle
WO2018215520A1 (fr) * 2017-05-24 2018-11-29 Drizzle Ip Ivs Appareil ménager domestique pour l'extraction de plantes
WO2022123082A1 (fr) * 2020-12-11 2022-06-16 Drizzle Holding Aps Dispositif d'extraction pour extraction d'huile végétale et procédé d'extraction
US20220305402A1 (en) * 2020-06-17 2022-09-29 Psilo Scientific Ltd Methanol-based extraction of psychoactive alkaloids from fungus

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB531224A (en) * 1938-09-24 1940-12-31 Gen Mills Inc Improvements in or relating to processes of producing a vitamin e concentrate and antioxidant from wheat germ oil, and the products resulting therefrom
WO2016053678A1 (fr) * 2014-09-30 2016-04-07 Noramco, Inc. Procédé d'extraction et de concentration d'alcaloïdes au moyen d'oxyde de diméthyle
WO2018215520A1 (fr) * 2017-05-24 2018-11-29 Drizzle Ip Ivs Appareil ménager domestique pour l'extraction de plantes
US20220305402A1 (en) * 2020-06-17 2022-09-29 Psilo Scientific Ltd Methanol-based extraction of psychoactive alkaloids from fungus
WO2022123082A1 (fr) * 2020-12-11 2022-06-16 Drizzle Holding Aps Dispositif d'extraction pour extraction d'huile végétale et procédé d'extraction

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