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WO2024209470A1 - Mélangeur d'ampoule - Google Patents

Mélangeur d'ampoule Download PDF

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Publication number
WO2024209470A1
WO2024209470A1 PCT/IL2024/050345 IL2024050345W WO2024209470A1 WO 2024209470 A1 WO2024209470 A1 WO 2024209470A1 IL 2024050345 W IL2024050345 W IL 2024050345W WO 2024209470 A1 WO2024209470 A1 WO 2024209470A1
Authority
WO
WIPO (PCT)
Prior art keywords
ampule
solution
mixer
chamber
drainage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/IL2024/050345
Other languages
English (en)
Inventor
Ruth EDRY
Omri EMODI
Salim Hadad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rambam Med Tech Ltd
Original Assignee
Rambam Med Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rambam Med Tech Ltd filed Critical Rambam Med Tech Ltd
Publication of WO2024209470A1 publication Critical patent/WO2024209470A1/fr
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/065—Rigid ampoules, e.g. glass ampoules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2072—Venting means for internal venting

Definitions

  • the present invention relates generally to a container comprising a solution. More specifically, the present invention relates to a mixer for mixing two solutions or a solution and a soluble solid in an external ampule.
  • Lidocaine must be stored in a solution, such as aqueous medium, as an acid with a pH of approximal 4.5 , for long shelf life.
  • a solution such as aqueous medium
  • acidic solution causes pain by direct stimulation of nociceptors in the tissue.
  • a base such as sodium bicarbonate
  • the solution pH is raised to a pH compatible with the gingiva’s (around 7.40) and the injection is not painful.
  • a base such as sodium bicarbonate
  • Adrenaline is added to most commercially available ampules of dental local anesthetics for its vasoconstrictive effect, causing prolongation of the local anesthesia by reduction of local anesthetic absorption.
  • Lidocaine hydrochloride with adrenaline bitartrate epinephrine
  • the most prevalent local anesthetic in dentistry is Lidocadren which is a mixture of lidocaine hydrochloride with adrenaline (e.g., bitartrate). Buffering lidocaine with sodium bicarbonate (8.4% sodium bicarbonate) 1 mEq/ml at a ratio of 9: 1 is the commonest method of reducing injection pain that has been demonstrated effective in numerous clinical studies.
  • Another main obstacle specific to dentistry is that the local anesthetic is marketed in a special ampule designated for use with a special reusable metal dental syringe.
  • the ampule is 100% full of local anesthetic solution with no space to add other solutions (no void volume).
  • For premixing it with sodium bicarbonate one must draw first some of the local anesthetic in the ampule out, then draw sodium bicarbonate in a different syringe and inject it into the dental ampule. This is not practical, especially considering the use of multiple ampules consecutively in a short period of time on one patient.
  • Another major barrier to hand mixing is the small measure of the dental ampule and its’ inlet which does not allow for easy operation.
  • an ampule mixer comprising: a longitudinal body having an open longitudinal chamber configured to receive an ampule comprising a material, wherein the material is selected from a first solution and a solvable solid; a volume changeable chamber comprising a second solution, and configured to change its volume under the application of an axial pressure; at least one injection needle having an inlet opening located in the volume changeable chamber and an injection outlet configured to inject the solution into the ampule by punching a flexible sealing of the ampule when the ampule is inserted and pressed against the volume changeable chamber.
  • the mixer when the material is the first solution the mixer further comprises a drainage chamber for excess of the first solution; and a drainage unit having a first opening located in the drainage chamber, and a second opening located inside the open longitudinal chamber and configured to puncture a flexible sealing of the ampule when the ampule is inserted into the longitudinal chamber, and then to drain an excess amount of the first solution from the ampule when the second solution is injected into the ampule.
  • the drainage unit may include at least one drainage needle crossing the volume changeable chamber, and configured to punch the flexible sealing of the ampule when the ampule is inserted and pressed against the volume changeable chamber.
  • the drainage chamber is held under sub-atmospheric pressure.
  • the drainage unit may include a unidirectional valve or a diaphragm located at the first opening and connectable to an overflow tube of the ampule, and wherein the longitudinal body has inner and outer walls, and the unidirectional valve is in fluid connection with a gap between the inner and outer walls, the gap is fluidically connected to the second opening.
  • the drainage unit may include at least one drainage needle encompassing the at least one injection needle, such that a gap is formed between the at least one drainage needle and the at least one injection needle, and thereby allowing the excess amount of the first solution to flow from the ampule to the drainage chamber.
  • the drainage chamber may be located between the longitudinal chamber and the volume changeable chamber.
  • the volume of the drainage chamber is at least 1% larger than the volume of the volume changeable chamber, prior to the application of the axial pressure.
  • the volume changeable chamber comprises at least one of collapsible walls, a piston, and elastic walls.
  • the mixer further comprises a mixing indicator, configured to indicate that a required amount of the second solution was injected into the ampule.
  • the indicator is selected from: a color marker, a mechanical clip, a sticker, a light emitting diode (LED), and an additive added to either the material or the solution that changes the color of the mixture when mixing the material and the second solution.
  • the excess amount of the first solution is between 0.1 to 2 ml.
  • the first solution is a lidocaine hydrochloride solution and the second solution is a sodium bicarbonate solution.
  • the ampule mixer is disposable.
  • the ampule is a dental ampule.
  • Some additional aspects of the invention are directed to a method of mixing two solutions comprising: receiving an ampule containing a first solution; inserting the ampule into an ampule mixer, such that a flexible sealing of the ampule is facing a volume changeable chamber located in a longitudinal body of the mixer; pressing the ampule against the volume changeable chamber of the mixer, such that an injection needle punches the flexible sealing; thereby injecting a second solution held in the volume changeable chamber into the ampule by the injection needle; and simultaneously extracting an excess amount of the first solution from the ampule into a drainage chamber of the mixer, using a drainage unit.
  • pressing the ampule is until receiving an indicator that a required amount of the second solution was injected into the ampule.
  • the indicator is selected from, a color marker, a mechanical clip, a sticker, a light emitting diode (LED), and an additive added to either the first solution or the second solution that changes the color of the mixture when mixing the first and second solutions.
  • the method further comprises extracting the mixture from the ampule using a syringe. In some embodiments, the method further comprises connecting the ampule to a IV infusion set. In some embodiments, the method further comprises extracting the mixture from the ampule using a syringe inserting the ampule into a syringe.
  • FIGs. 1A, IB, 1C, and ID are illustrations of an ampule mixer according to some embodiments of the invention.
  • FIGs. IE, IF, 1G, and 1 H are illustrations of another ampule mixer according to some embodiments of the invention.
  • FIG. 2 is a flowchart of a method of mixing two solutions according to some embodiments of the invention.
  • FIGs. 3A, 3B, and 3C are illustrations of some of the steps in the method of mixing two solutions according to some embodiments of the invention.
  • FIGs. 3A, 3B, and 3C are illustrations of some of the steps in the method of mixing two solutions according to some embodiments of the invention.
  • Some aspects of the invention may be directed to an ampule mixer that allows a simple mixing of two solutions (e.g., drugs, medications, chemicals, etc.) or a solvable solid and a solution, prior to use (e.g., a medical use).
  • the user may be mixing two solutions (e.g., lidocaine hydrochloride and sodium bicarbonate) prior to injecting of the mixture to a patient.
  • a device may include a mixer that may receive an ampule comprising the material selected from, a first solution and solvable solid.
  • the device may include a chamber/container that may include a second solution, and may further include at least one injection needle configured to inject the second solution into the ampule. Thereby allowing the material to be mixed with the second solution, in one simple act.
  • an ampule may include any sealed container configured to hold/contain/encompass a solution, for example, a medical drug, medical solution, and the like.
  • An ampule mixer 100 may include a longitudinal body 110 having an open longitudinal chamber 112 configured to receive an ampule 10 comprising a material 15 selected from, a first solution and solvable solid.
  • ampule 10 may be a standard commercial ampule or a specially designed ampule.
  • material 15 may be a drug (e.g., lidocaine, Lidocadren, or any other anesthetic) and ampule 10 may be a dental ampule.
  • the internal diameter of longitudinal body 110 may be at least 0.0001 % larger than the external diameter of ampule 10.
  • ampule mixer 100 may include a volume changeable chamber 120 comprising a second solution 12 (shown in Fig. 1C) and configured to change it’s volume (e.g., to compress) under the application of axial pressure.
  • second solution 12 may include any other solution such as sodium bicarbonate solution, or another drug.
  • volume changeable chamber 120 comprises at least one of: collapsible walls (e.g., the harmonica-type walls illustrated), a piston (illustrated in Figs. IE to 1H), elastic walls, and the like.
  • harmonica-type wall illustrated in 1 A, IB, 1C, and ID is given as an example only, and any chamber that is configured to change it’s volume /compress under the application of an external pressure is within the scope of the invention.
  • ampule mixer 100 may include at least one injection needle 130 having an inlet opening 132 located in the volume changeable chamber and an injection outlet 134 configured to inject the second solution into the ampule by punching a flexible sealing 16 of the ampule 10 when the ampule is inserted and pressed against the volume changeable chamber.
  • flexible sealing 16 may include any material capable of sealing material 15 inside ampule 10, for example, an aluminum cover, a polymeric cover, and the like.
  • injection outlet 134 may include one or more side openings, located on the wall of injection needle 130, such that second solution 12 may exit sideway from the wall of injection needle 130. Additionally or alternatively, injection outlet 134 may be located at the tip of injection needle 130, thus allowing second solution 12 to exit from the tip/end of injection needle 130.
  • the length of injection needle 130 and/or the location of the side openings may be determined to ensure effective mixing of material 15 with second solution 12. For example, the length of injection needle 130 may be at least 50% of the internal length of ampule 10, thereby injecting solution 12 into the ampule away from flexible sealingl6.
  • ampule mixer 100 may further include a drainage chamber 140 and a drainage unit 150 having a first opening 152 located in the drainage chamber 150, and a second opening 154 located inside the open longitudinal chamber and configured to drain an excess amount of the first solution from the ampule when the second solution is injected into the ampule.
  • some sub-atmospheric pressure must be formed by draining a sufficient amount of first solution 15 from ampule 10.
  • the insertion of second solution 12 into ampule 10 and the draining of the excess amount of first solution 15 may be done simultaneously.
  • the amount of second solution 12 inserted into ampule 10 from chamber 120 is substantially the same as the amount of first solution 15 drained out from ampule 10 into drainage chamber 140.
  • the volume of drainage chamber 140 is at least 5% larger than the volume of volume changeable chamber 120, prior to the application of the axial pressure. Therefore, if the entire volume of volume changeable chamber 120 is filled with second solution 12 and all of second solution 12 is injected into ampule 10, drainage chamber 140 may have sufficient volume for receiving the drained first solution 15.
  • the excess amount of first solution 15 is between 0.1 to 2 ml.
  • drainage unit 150 may comprise at least one drainage needle (as illustrated) crossing volume changeable chamber 120, and configured to punch flexible sealing 16 of the ampule when ampule 10 is inserted and pressed against volume changeable chamber 120.
  • the drainage needle may be made of metal, a polymer, or any other suitable material.
  • drainage chamber 140 is held under sub-atmospheric pressure, to increase the suction/evacuation of the excess amount of first solution 15 from ampule 10 during and after the insertion of second solution 12 to ampule 10.
  • drainage unit 150 may include a unidirectional valve or a diaphragm (not illustrated) located at first opening 152 and connectable to an overflow tube (not illustrated) of ampule 10.
  • longitudinal body 110 may have inner and outer walls (not illustrated), and the unidirectional valve is in fluid connection with a gap between the inner and outer walls, the gap is fluidically connected to the second opening.
  • ampule mixer 100 may be a disposable device for a single use.
  • ampule 100 may be a reusable device and volume changeable chamber 120 may be a replaceable element such as a single-use chamber filled with second solution 12, or a refillable element ready for multiple refills with second solution 12 after each circle.
  • ampule mixer 100 may be a stand-alone unit.
  • multiple units of ampule mixer 100 may be mounted on a single platform (disposable or reusable), as illustrated in Figs 3 A-3C.
  • ampule mixer 100 may further include a mixing indicator (not illustrated), configured to indicate that a required amount of the second solution 12 was injected into the ampule 10. Accordingly, once the user presses ampule 10 against chamber 120, the indicator may show/send/sound an indication to the user only after the required amount of the second solution 15 was injected into the ampule.
  • mixing indicators may include, a color marker, a mechanical clip, a sticker, a light emitting diode (LED), and an additive added to either the material or the second solution that changes the color of the mixture when mixing the first and second solutions.
  • the indicator may include or may be in communication with a sensor, such as, a pH sensor, volume sensor, thermometer, pressure sensor, and the like.
  • the sensor may measure a value indicative of the amount of second solution 12 mixed with material 15 in ampule 10, for example, a change in the pH of solution 15, change in volume, temperature, pressure and the like.
  • the mixing indicator may be a mechanical clip configured to be locked/pressed/make a clicking noise once volume changeable chamber 120 is compressed to an extent that allows a sufficient amount of second solution 12 to be injected into ampule 10.
  • ampule mixer 100 may further be covered by a cap or cover 160, for example, for ensuring sterile conditions inside longitudinal body 110 prior to opening of longitudinal body 110 and the insertion of ampule 10 to mixer 100.
  • An ampule mixer 1000 may include a longitudinal body 1100 having an open longitudinal chamber 1120 configured to receive ampule 10 comprising material 15 shown and discussed with respect to Figs. 1 A-1D herein above.
  • the internal diameter of longitudinal body 1100 may be at least 0.0001 % larger than the external diameter of ampule 10.
  • ampule mixer 1000 may include a volume changeable chamber 1200 comprising a second solution 12 (shown in Fig. 1C of mixer 100) and configured to change it’s volume under the application of axial pressure.
  • volume changeable chamber 1200 may include a piston (e.g., a syringe piston) 1250 configured to inject second solution 12 into at least one injection needle 1300.
  • piston 1250 may include a piston seal 1255.
  • ampule mixer 1000 may include at least one injection needle 1300 having an inlet opening 1320 located in volume changeable chamber 1200 and an injection outlet 1340 configured to inject the second solution into the ampule by punching flexible sealing 16 (illustrated in Figs. 1A-1D) of ampule 10 when the ampule is inserted and pressed against volume changeable chamber 1200.
  • ampule mixer 1000 may further include a drainage chamber 1400 and a drainage unit 1500, shown in details in Fig. 1H, having a first opening 1520 located in the drainage chamber 1500, and a second opening 15401ocated inside open longitudinal chamber 1100 and configured to drain an excess amount of the first solution from the ampule when the second solution is injected into the ampule.
  • drainage unit 1500 may include (e.g., is) at least one drainage needle encompassing at least one injection needle 1300, such that a gap 1550 (shown in Fig. 1H) is formed between at least one drainage needle 1500 and the at least one injection needle 1300, and thereby allowing the excess amount of the first solution to flow from the ampule to drainage chamber 1400.
  • drainage chamber 1500 may be located between the longitudinal chamber 1100 and volume changeable chamber 1200.
  • volume changeable chamber 1200, and drainage chamber 1400 may be housed in housing 1110.
  • ampule mixer 1000 may include additional elements such as any number of required seals, as illustrated.
  • ampule mixer 100 may be a disposable device for a single use.
  • ampule 100 may be a reusable device and volume changeable chamber 120 may be a replaceable element such as a single-use chamber filled with second solution 12, or a refillable element ready for multiple refills with second solution 12 after each circle.
  • ampule mixer 100 may be a stand-alone unit.
  • multiple units of ampule mixer 100 may be mounted on a single platform (disposable or reusable), as illustrated in Figs 3 A-3C.
  • ampule mixer 1000 may further include a mixing indicator (not illustrated), configured to indicate that a required amount of the second solution 12 was injected into the ampule 10 as discussed herein above with respect to ampule mixer 100.
  • a mixing indicator (not illustrated), configured to indicate that a required amount of the second solution 12 was injected into the ampule 10 as discussed herein above with respect to ampule mixer 100.
  • ampule mixer 1000 may further be covered by a cap or cover (e.g., cover 160 illustrated in Fig. IB), for example, for ensuring sterile conditions inside longitudinal body 110 prior to opening of longitudinal body 1100 and the insertion of ampule 10 to mixer 1000.
  • a cap or cover e.g., cover 160 illustrated in Fig. IB
  • Fig. 2 is a flowchart of a method of mixing two solutions according to some embodiments of the invention.
  • the method of Fig. 2 may be performed by a user (e.g., a professional) using ampule mixer 100/1000, disclosed herein above.
  • the method may include taking an ampule containing a material selected from, a first solution and solvable solid.
  • a dentist or an assistant may prepare an ampule 10 filled with lidocaine hydrochloride solution.
  • the method may include inserting the ampule into an ampule mixer, such that a flexible sealing of the ampule is facing a volume changeable chamber located in a longitudinal body of the mixer.
  • a set of ampule mixers 100/1000 may be provided to a user, as illustrated in Figs 3A, 3B and 3C.
  • the user may remove cover 160 from one mixer 100, as shown in Fig. 3A, and may insert ampule 10 into longitudinal body 110/1100, as shown in Figs. 3B and 3C.
  • the set of ampule mixers shown in Figs 3 A, 3B, and 3C is given as an example only, the mixers may be provided in separate packages comprising any number of mixers from 1 to n, wherein n is an integer.
  • the invention is not limited to the upper insertion direction shown in Figs 3A, 3B, and 3C, and the user may hold mixer 100/1000 and insert ampule 10 form the bottom, side or any direction according to the user’s convenience or demand.
  • the method may include pressing the ampule against the volume changeable chamber of the mixer, such that an injection needle punches the flexible sealing.
  • ampule 10 may be pressed against volume changeable chamber 120/1200, at least until injection needle 130/1300 punches flexible sealing 16.
  • the punching may cause the injection of second solution 12 held in volume changeable chamber 120/1200 into ampule 10 by injection needle 130/1300.
  • ampule 10 may be compressed against volume changeable chamber 120/1200 until a sufficient amount of second solution 12 is injected into ampule 10, for example, until receiving an indicator that the required amount of the second solution was injected into the ampule.
  • the indicator is selected from, a color marker, a mechanical clip, a sticker, a light emitting diode (LED), and an additive added to either the first solution or the second solution that changes the color of the mixture when mixing the first and second solutions.
  • the method may include extracting an excess amount of the first solution from the ampule into a drainage chamber of the mixer, using a drainage unit.
  • an excess amount of first solution 15 may be extracted from ampule 10 into drainage chamber 140/1400 by drainage unit 150/1500, as discussed herein above.
  • the method may further include separating the ampule from the ampule mixer and inserting the ampule into a syringe, as illustrated in Fig. 3C.
  • an indicator e.g., a LED connected to a pH sensor
  • the ampule is a dental ampule comprising lidocaine hydrochloride (the first solution) mixed with sodium bicarbonate (the second solution) to be inserted into a dental syringe.
  • the invention is not limited to dental applications, and the ampule comprising both the first and second solutions after mixing may be connected to any field delivery system such as, an IV cannula, a catheter, and injecting needle, an IV infusion set, a delivery pump and the like.
  • An ampule mixer may also be used for mixing two powder drug formulations, dissolving a solid dose form formulation such as lyophilized solid drugs and lyophilized biological drugs and hormones, and the like.
  • an ampule mixer may allow simple mixing of two solutions or solid and solution or solid and solid prior to use, for example, a medical use.

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention divulgue un mélangeur d'ampoule. Le mélangeur d'ampoule comprend : un corps longitudinal comportant une chambre longitudinale ouverte configurée pour recevoir une ampoule comprenant un matériau, le matériau étant choisi parmi une première solution et un solide soluble ; une chambre à volume variable comprenant une seconde solution et configurée pour se comprimer axialement sous l'application d'une pression axiale ; au moins une aiguille d'injection comportant une ouverture d'entrée située dans la chambre à volume variable et une sortie d'injection configurée pour injecter la solution dans l'ampoule par poinçonnage d'une étanchéité souple de l'ampoule lorsque l'ampoule est insérée et pressée contre la chambre à volume variable.
PCT/IL2024/050345 2023-04-04 2024-04-04 Mélangeur d'ampoule Pending WO2024209470A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363456823P 2023-04-04 2023-04-04
US63/456,823 2023-04-04

Publications (1)

Publication Number Publication Date
WO2024209470A1 true WO2024209470A1 (fr) 2024-10-10

Family

ID=92971811

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2024/050345 Pending WO2024209470A1 (fr) 2023-04-04 2024-04-04 Mélangeur d'ampoule

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Country Link
WO (1) WO2024209470A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360410A (en) * 1991-01-16 1994-11-01 Senetek Plc Safety syringe for mixing two-component medicaments
US5603695A (en) * 1995-06-07 1997-02-18 Erickson; Kim Device for alkalizing local anesthetic injection medication
US20020022804A1 (en) * 1999-03-10 2002-02-21 Eric Connolly Syringe device
US20150359710A1 (en) * 2013-01-31 2015-12-17 Yiling DING Medicinal cefoxitin vial, and dispensing apparatus and injection apparatus thereof
WO2022094542A1 (fr) * 2020-10-26 2022-05-05 Octodent Llc Dispositifs, systèmes et procédés de mélange de médicaments

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360410A (en) * 1991-01-16 1994-11-01 Senetek Plc Safety syringe for mixing two-component medicaments
US5603695A (en) * 1995-06-07 1997-02-18 Erickson; Kim Device for alkalizing local anesthetic injection medication
US20020022804A1 (en) * 1999-03-10 2002-02-21 Eric Connolly Syringe device
US20150359710A1 (en) * 2013-01-31 2015-12-17 Yiling DING Medicinal cefoxitin vial, and dispensing apparatus and injection apparatus thereof
WO2022094542A1 (fr) * 2020-10-26 2022-05-05 Octodent Llc Dispositifs, systèmes et procédés de mélange de médicaments

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