WO2024259730A1 - Anti-oil and anti-acne shower gel and production method therefor - Google Patents

Abstract

An anti-oil and anti-acne shower gel, comprising the following raw material components in percentage by weight: 10-18% of a surfactant, 0.3-1% of a thickening agent, 0.5-2% of sodium chloride, 0.05-0.2% of a pH regulator, 0.1-0.6% of azelaic acid, 0.1-0.5% of caprylylglycine, 0.1-0.6% of a plant acaricide, 0.2-2% of a radix sophorae flavescentis extract, 0.01-0.1% of an Epilobium fleischeri extract, 0.1-0.5% of a saccharide isomeride mixture, 0.1-0.5% of sodium ascorbyl phosphate, 0.5-1.5% of a Tremella extract, 0.01-0.2% of a gentian extract, 0.3-0.7% of a preservative, and the balance of water.

Description

Oil-controlling and acne-removing shower gel and preparation method thereof Technical Field

The invention relates to the field of daily cosmetics, and in particular to an oil-controlling and acne-removing shower gel and a preparation method thereof.

Background Art

Shower gel has gradually become the most commonly used and consumed daily necessity in people's daily life. With the improvement of people's living standards, people's requirements for shower gel are getting higher and higher. At present, most of the common shower gels on the market contain more chemical ingredients. Frequent use will destroy the balance of skin moisture and oil, easily causing problems such as dry skin, oily skin, and acne. Long-term use is not good for people's skin health.

Summary of the invention

The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides an oil-controlling acne-removing shower gel and a preparation method thereof.

The technical solution adopted by an embodiment of the present invention to solve the technical problem is:

An oil-controlling and acne-removing shower gel comprises the following raw materials in percentage by weight: 10-18% of a surfactant, 0.3-1% of a thickener, 0.5-2% of sodium chloride, 0.05-0.2% of a pH regulator, 0.1-0.6% of azelaic acid, 0.1-0.5% of capryloyl glycine, 0.1-0.6% of a plant mite remover, 0.2-2% of a sophora flavescens extract, 0.01-0.1% of an epilobium fleischerii extract, 0.1-0.5% of a sugar isomer mixture, 0.1-0.5% of sodium ascorbyl phosphate, 0.5-1.5% of a tremella extract, 0.01-0.2% of a gentian extract, 0.6% of a preservative and the remainder of water.

Preferably, the surfactant is composed of sodium laureth sulfate, sodium methyl cocoyl taurate, cocamidopropyl betaine, sodium lauroamphoacetate, and cocamide methyl MEA.

Preferably, the plant acaricide is composed of thyme extract, rosemary water, 1,3-propylene glycol, dichlorobenzyl alcohol and phenoxyethanol.

Preferably, the thickener consists of tocopherol and PEG-120 methyl glucose dioleate.

Preferably, the sugar isomer mixture comprises sugar isomers, water, citric acid and sodium citrate.

Preferably, the pH adjuster is potassium hydroxide.

The above-mentioned oil-controlling and acne-removing shower gel is prepared by a preparation method comprising the following steps:

S1: Divide the water into two parts, put the first part of water into the production pot, heat it to 80-85℃, add surfactant and stir until it is evenly dissolved;

S2: Continue to add thickener, azelaic acid, and capryloyl glycine into the production pot and stir until they are evenly dissolved;

S3: Cool down to 45°C, add plant acaricide, Sophora flavescens extract, pH adjuster, sugar isomer mixture, sodium ascorbyl phosphate, Tremella fuciformis extract, Gentiana scabra extract, and Epilobium freiherb extract, and stir to dissolve evenly;

S4: Sodium chloride is first completely dissolved with the second part of water and then put into the production pot and stirred evenly, and the pH and viscosity are adjusted and the material is discharged.

Beneficial effects of the present invention:

1. In view of acne/pimples caused by abnormal regulation of sebaceous glands by androgens and abnormal keratinization of sebaceous gland ducts, this application uses the synergistic effect of azelaic acid and epilobium fleischer extract to achieve the effect of removing acne and controlling oil. Azelaic acid, also known as azelaic acid, is currently mainly used to treat melanoma, chloasma, rosacea, hyperpigmentation, acne, etc. Mechanism of action of azelaic acid: inhibiting skin oil secretion. Androgen, especially dihydrotestosterone, induces the activity of sebaceous glands, which is one of the causes of acne. 5a-reductase in sebaceous glands can increase the bioconversion of testosterone into dihydrotestosterone, and azelaic acid can produce a competitive concentration inhibitory effect on this reductase, thereby reducing oil secretion of the skin; it has an anti-keratinization effect on normal skin and acne-infected skin, reduces the synthesis of filamentous keratin, prevents excessive keratinization of hair follicles, and unclogs pores. At the same time, the epilobium fleischer extract added to the formula also has a strong inhibitory effect on 5a-reductase. By combining Epilobium schreberi extract with azelaic acid, the amount of azelaic acid used and skin irritation can be reduced, while achieving significant acne-removing and oil-controlling effects.

2. For acne/pimples caused by excessive growth of Propionibacterium acnes, capryloyl glycine has good skin affinity and is mild to the skin. At the same time, it can achieve a good inhibitory effect on Propionibacterium acnes and Staphylococcus aureus in a relatively short time (2min-5min), and has a significant effect on the prevention and treatment of acne and pimples. Therefore, this formula selects capryloyl glycine as the active ingredient to inhibit Propionibacterium acnes, which fully considers its characteristics of short action time and high action efficiency, and also considers its mildness to the skin.

3. For acne/pimples caused by inflammatory immune response, it is mainly achieved through Sophora flavescens extract. Sophora flavescens extract has a broad-spectrum antibacterial property, which can not only inhibit the biosynthesis of bacteria, but also affect the biological oxidation process of bacteria. The anti-inflammatory mechanism of Sophora flavescens extract is due to the stabilization of the red blood cell membrane, and it has a strong immunomodulatory effect. It can exert its anti-inflammatory effect through the changes in immune cells, cytokines and other inflammatory regulatory factors. It has a good effect on eczema and dermatitis, can relieve skin itching caused by inflammation, and accelerate the repair of acne skin.

4. For acne/pimples caused by skin mites, a plant-based mite remover is added to the formula. The main active ingredients of the mite remover are: thyme extract, rosemary, water and dichlorobenzyl alcohol. It has a strong killing and repelling effect on various types of mites. It can effectively prevent or relieve acne caused by mites.

To sum up, the compatibility mechanism of the acne-removing and oil-controlling ingredients in this formula covers various pathogenesis of acne/pimples, and can achieve more significant acne-removing and oil-controlling effects. At the same time, it also takes into account the mildness and safety of the overall formula, and is suitable for a wider range of people. It can not only be used for acne removal on acne-prone skin, but also for daily cleansing to prevent acne.

BRIEF DESCRIPTION OF THE DRAWINGS

The above and/or additional aspects and advantages of the present invention will become apparent and easily understood from the description of the embodiments in conjunction with the following drawings, in which:

FIG1 is a schematic diagram of the effect of use by subject 1;

FIG2 is a schematic diagram of the effect of use by subject 2;

Figure 3 is a comparison of ISGA scores at different time points (x±s, n=30);

Figure 4 shows the average volume change of acne (mm, x±s, n=30);

FIG5 shows the changes in skin oil content (μg/cm, x±s, n=30).

DETAILED DESCRIPTION

Specific implementation methods are very important for fully disclosing, understanding and reproducing the invention, supporting and explaining the claims. The description of the implementation method should be consistent with the technical solution adopted to solve the technical problem. For simple technical solutions, only one embodiment can be given. For technical solutions with a wider protection scope, more than one embodiment should be given to support the scope of the protection required.

Example of recipe of embodiment

The preparation method is as follows:

1. Accurately weigh the ingredients in the formula and clean the production equipment;

2. Add raw material No. 1 (reserve 5% water) to the stirring pot, heat to 80-85°C, add raw materials No. 2 and 3, and stir until completely dissolved;

3. Add raw materials 4, 5 and 6 in sequence and stir for 20 minutes until they are evenly dissolved;

4. Add raw materials 7, 8, and 9 in sequence, stir until completely dissolved and then cool down;

5. Cool down to 45℃, add raw materials 10, 11, 12, 13, 14, 15, 16, 17, and 18. Stir each raw material evenly before adding the next one;

6. Add the remaining water-dissolved raw material No. 19, adjust the pH and viscosity, and then conduct sampling inspection;

7. After passing the inspection, the semi-finished products are discharged and stored;

8. Filling, packaging and coding;

9. Products will be put into storage after passing random inspection.

The plant mite remover used in this application is produced and provided by Guangdong Dimei New Material Technology Co., Ltd.

Skin occlusive patch test Skin reaction test

1. Materials and Methods

1. Test substance: original cosmetic final product (diluted to 1% aqueous solution).

2. Control: blank filter paper control.

3. Subjects: A total of 30 subjects, including 1 male and 29 females, aged 21 to 59 years old, with an average age of 39.77±12.14 years old, met the voluntary inclusion criteria.

4. Test method: Select qualified patch test equipment and use closed patch test method. Place about 0.020mL-0.025mL (liquid) of diluted test substance in the patch tester and apply it to the back of the subject with low-allergenic tape. Remove the test substance after 24 hours and observe the skin reaction at 0.5, 24 and 48 hours after removal. Record the results according to the skin reaction grading standard in the "Technical Specification for Safety of Cosmetics" (2015 edition).

Skin occlusive patch test skin reaction grading standard

2. Test results

Summary of cosmetics human skin patch test results

The results showed that: the human skin patch test results showed that 6 cases of grade 1 adverse skin reactions occurred among 30 people.

Acne removal and oil control effect experiment

1. Materials and Methods

1. Test substance: original cosmetic final product

2. Comparison: Compare yourself before and after

3. Subjects: A total of 30 subjects (33 subjects were enrolled and 3 subjects dropped out), including 14 females and 16 males, aged 18 to 40 years old, with an average age of 29.50±6.31 years old, who met the subject inclusion criteria.

4. Instrument measurement parameters and related equipment:

5. Test environment: temperature: 20℃～22℃, humidity: 40%～60%, and real-time dynamic monitoring.

6. Test methods:

6.1 Test Purpose and Principle

At least 30 subjects were recruited to use the test samples for 28 consecutive days. The improvement level of acne lesions was evaluated subjectively and by doctors. Antera 3D was used to collect and analyze the corresponding parameters of acne on the subjects' backs. The test probe SM815 was used to measure the oil content on the skin surface. The changes in various indicators before and after use were compared to determine the acne removal and oil control effects of the product.

6.2 Experimental design principles

Double-blind, randomized, self-controlled

6.3 Subject Screening

6.3.1 Number of subjects: minimum valid number of 30 subjects

6.3.2 Subject conditions:

6.3.2.1 Inclusion criteria:

(1) Applicants should be healthy male or female and aged between 18 and 45 years.

(2) The patient is in good general health and has no major systemic diseases.

(3) There are two or more acne spots on the back.

(4) Able to strictly follow the requirements and time schedule of the research plan and sign the informed consent form and confidentiality agreement.

6.3.2.2 Exclusion criteria:

(1) Women who are currently pregnant, breastfeeding, or planning to become pregnant in the next two months.

(2) Acute inflammation or other skin diseases on the back (such as eczema, lupus erythematosus, seborrheic dermatitis, psoriasis, severe epidermal exfoliation, etc.).

(3) Those with a highly sensitive constitution or allergy to cosmetics.

(4) Those with obvious sunburn, scars, excessive hair on the back or other conditions that may affect the test results.

(5) Any medications taken orally or topically in the past month that may affect skin condition or reaction, such as antihistamines, antibiotics, insulin, anti-inflammatory drugs, vitamin A, steroid drugs, aspirin, thyroid drugs, etc.

(6) Those who have used hormone drugs or immunosuppressants in the past month.

(7) Those who are currently or have participated in other clinical trials within the past month.

(8) Have had cosmetic treatments on the back such as chemical peel (fruit acid treatment), microdermabrasion, laser resurfacing, etc. within the past three months.

(9) Acne classified as grade IV according to the International Modified Acne Scale and Pillsbury classification.

6.3.2.3 Exclusion criteria: serious adverse reactions during the test and non-compliance with the R&D plan (such as using other cosmetics or drugs during the test and requesting to withdraw for other reasons)

Table 1 International modified acne grading system

6.4 Preparation before the test

No product can be used on the test site on the day of the test. Before the test, the subjects need to be in the human efficacy evaluation room (temperature: 20℃～22℃,

Humidity: 40% to 60%) Sit quietly for 30 minutes without drinking water or beverages. Keep the subject relaxed and avoid touching the back.

Before the trial, the subjects were given an explanation of the experiment and signed an informed consent form.

The test area was the back.

6.5 Product Usage

When bathing, take an appropriate amount of the test product to replace the usual bath products, rub the whole body gently and then wash. Use once a day for 28 consecutive days. During the trial, the subjects are prohibited from using acne-removing, oil-controlling, anti-inflammatory and antibacterial preparations; the subjects are prohibited from dripping, injecting, orally or taking other forms of preparations that affect acne-removing and oil-control tests; the subjects are mainly indoor activities and avoid long-term exposure to outdoor light.

6.6 Subjective evaluation

During the follow-up visit 28 days after using the product (D28), the subjects filled out a questionnaire in the human efficacy laboratory to evaluate the back condition and record the score. The 7-point scoring method was used to score the product in four aspects: skin feel, use effect, mildness and use satisfaction, and then make a judgment, and record it once for each follow-up visit.

6.7 Semi-quantitative evaluation (doctor's evaluation)

The dermatologists evaluated the acne lesions on the subjects' backs in the photos before using the product (D0) and 28 days after using the product (D28). The improvement of the lesion symptoms before and after use of the subjects was scored using the ISGA scale (Table 2), and the percentage of lesion reduction was calculated.

Table 2 ISGA scale

6.8 Objective and quantitative evaluation

After resting for 30 minutes in the human efficacy evaluation room, the subjects were photographed with the Antera 3D skin image analyzer at the back acne site. The average volume of acne in the test area was obtained through software analysis. The SM815 was used to detect the skin oil value at the test site. The measured value was used as the baseline value (D0). The product was then distributed and the use method was instructed. The subjects were required to return for a visit 28 days (D28) after using the product and undergo the same indicator test.

The test of the same subject should be completed by the same instrument and the same tester. The test site should be kept consistent between the two test time points.

6.9 Statistical analysis

The measured values of each test area were statistically analyzed, including quantity, mean, standard deviation, standard error, minimum value, median, maximum value, etc. If the test data is normally distributed, the paired t-test method is used for statistical analysis; if the test data is non-normally distributed, the rank sum test method is used for statistical analysis. The statistical methods all use two-tailed tests, and the test level α=0.05. SPSS 25.0 software was used for statistical analysis of data statistics. When the results show significant differences, they are marked with *p<0.05 and **p<0.01 respectively. *p<0.05 indicates a significant difference, and **p<0.01 indicates an extremely significant difference. If there are significant differences in the values of the various indicators in the test area, it means that the product has acne removal and oil control effects.

2. Test results

During the trial, 33 subjects were enrolled, 3 dropped out (automatically withdrew due to personal reasons), and finally 30 subjects met the protocol and were effective cases. Among them, there were 14 females and 16 males, with an average age of 29.50±6.31 years old; this study used this population for statistical analysis

1. Safety and adverse reaction evaluation

During the trial, professional dermatologists asked the subjects whether they experienced dryness, oiliness, scaling, redness, stinging and other symptoms while using the tested products, and observed and recorded whether there were rashes, redness, swelling and scaling on the back. Then the scores were scored according to the scoring criteria in Table 3, and the scores were recorded in the event report form, and the correlation was evaluated according to the criteria listed in Table 4. During the trial, no subjects experienced adverse reactions. Table 3 Scoring criteria for adverse reactions

Table 4 Evaluation of the tested products

2. Subjective evaluation

The 7-point scoring method (Table 5) was used to score the product's use effect, mildness, and use satisfaction in the questionnaire. The subjects filled in the questionnaire 4 weeks after trying the product (D28). The subjects' evaluation and satisfaction with the product's use experience and efficacy were analyzed.

Table 5 Self-assessment scoring standards (7-level scoring method)

The following are charts based on the statistics of the questionnaires filled out by the subjects, and conclusions are drawn from the data in the tables and charts.

2.1 Product skin feel evaluation

Table 6 Product skin feel evaluation results (n=30)

From the perspective of product skin feel, the average score was above 6.1 points, and statistically more than 50% of the subjects gave positive comments on the product skin feel. On D28, the average score of "the back skin does not feel tight after use" was 6.17 points, and 96.67% of the subjects agreed; on D28, the average score of "gentle and non-irritating" was 6.30 points, and 100.00% of the subjects agreed.

2.2 Product use effect evaluation

After 4 weeks of use (D28), the subjects evaluated the acne removal and oil control effects of the product. The questionnaire data statistics are as follows:

2.2.1 Acne-removing effect

Table 7 Evaluation results of product anti-acne effect (n=30)

In terms of acne removal, after 28 days of use (D28), all average scores were above 5.8 points, and more than 50% of the subjects gave positive comments on the acne removal effect of the product. Among them, "it has a soothing effect on the redness and swelling of the acne area after use" and "the skin feels smoother after use" were both recognized by 93.33% of the subjects at D28; "the size of the raised acne on the back has become smaller after use" was recognized by 96.67% of the subjects at D28; "after use, the acne-prone skin quality has improved and the number of acne has decreased" was recognized by 90.00% of the subjects at D28.

2.2.2 Oil control effect

Table 8 Evaluation results of product oil control effect (n=30)

In terms of oil control, after 28 days of use (D28), all average scores were above 5.9 points, and more than 50% of the subjects gave positive comments on the oil control effect of the product. Among them, "I feel that the oiliness of the back skin has decreased after use" was recognized by 100.00% of the subjects at D28; "The back skin feels refreshed after use" was recognized by 90.00% of the subjects at D28.

2.3 Product Satisfaction Evaluation

Table 9 Product satisfaction evaluation results (n=30)

In terms of overall product satisfaction, after 28 days of use (D28), more than 50% of the subjects gave positive comments on the product satisfaction survey results. At D28, 93.33% of the subjects were satisfied with the product.

3. Semi-quantitative evaluation (doctor evaluation)

Dermatologists evaluated the acne lesions on the subjects' backs before and after using the product. The ISGA scale was used to score the improvement of the lesion symptoms before and after use, and the percentage of lesion reduction was calculated. The percentage of lesion reduction was calculated using Formula 1. By comparing the ISGA scores before and after use, the acne removal efficacy of the product can be reflected.

Skin lesion reduction percentage = (ISGA score before using the product - ISGA score after using the product) / ISGA score before using the product × 100%

Table 10 Comparison of ISGA scores before and after use (x±s, n=30)

The evaluation results are shown in Table 10 and Figure 3 (the baseline values and the values at the time of the follow-up visit were analyzed using the rank sum test. Significant differences are marked with *p<0.05, **p<0.01):

Compared with the baseline value before use (D0), the ISGA skin lesion score showed a downward trend after using the product. After 28 days of use (D28), the percentage of skin lesion reduction was 36.51%, and there was a very significant difference between the two (p<0.01).

4. Analysis of average volume of acne

The acne area images taken by Antera3D can be analyzed by software to measure the average volume change of acne in the AOI selected area at different time points. By comparing the average volume change of acne before and after use, the acne removal effect of the product can be reflected.

The more the average volume of acne at different follow-up time points decreases compared with the baseline value before use (D0), the better the improvement effect of acne lesions is, indicating that the acne removal effect of the product is better.
Average acne volume reduction rate = (average acne volume before using the product - average acne volume after using the product) /
Average volume of acne before using the product × 100%

Table 11 Descriptive statistics of average volume of acne (mm, n = 30)

Table 12 Analysis of differences in average volume of acne (mm, x±s, n=30)

The test results are shown in Table 12 and Figure 4 (paired t-test was used to analyze the difference between the baseline value and the return visit time point value of the average volume of acne. Significant differences are marked with *p<0.05, **p<0.01):

Compared with the baseline value before use (D0), the average volume of acne showed a downward trend after using the product, and decreased by 74.17% after 28 days of use (D28), which was significantly different from the baseline value (p<0.01). The average volume of acne after using the product was lower than the baseline value.

5. Analysis of skin surface oil content

The larger the value of the skin surface sebum content measured by Sebumeter SM815, the higher the skin surface oil content. By comparing the changes in oil content in a specific area of the skin before and after use, the oil control effect of the product can be reflected. The more the sebum content at different return visit time points decreases compared to the baseline value before use (D0), the better the improvement effect of the surface oil content in the test area, indicating that the product is more effective in reducing the oil content on the skin surface.

Skin oil content reduction rate = (oil content before using the product - oil content after using the product) / oil content before using the product × 100%

Table 13 Descriptive statistics of skin oil content (μg/cm, n=30)

Table 14 Analysis of differences in skin oil content (μg/cm, x±s, n=30)

The test results are shown in Table 14 and Figure 5 (the baseline values and the values at the time of the return visit were analyzed for differences using the rank sum test. Significant differences are marked with *p<0.05, **p<0.01):

Compared with the baseline value before use (DO), the oil content on the skin surface showed a downward trend after using the product. After 28 days of use (D28), it decreased by 45.39%, which was significantly different from the baseline value (p<0.01). After using the product, the oil content on the skin surface was lower than the baseline value.

3. Test Conclusion

The acne removal and oil control effects of cosmetics were evaluated by using the Beti Oil Control Anti-acne Shower Gel provided by Zhongshan Changxing Industrial Co., Ltd. for multiple times on 30 subjects. The results showed that:

1. No adverse reactions occurred in this trial, and the trial product has high safety.

2. Subjective evaluations by the subjects showed that after 28 days of use (D28), the mean scores were all above 5 points. Statistically, more than 50% of the subjects gave positive comments on the product's skin feel, acne removal, oil control effect, mildness and satisfaction. At D28, 100% of the subjects agreed with "I feel that the oiliness of the back skin has decreased after use" and "The product is mild and non-irritating"; more than 90% of the subjects agreed with "It has a soothing effect on the redness and swelling of the acne area after use", "I feel that the size of the raised acne on the back has become smaller after use", "I feel that the skin has become smoother after use", "I feel that the acne-prone skin has improved after use, and the number of acne has decreased", "I feel that the back skin feels refreshed after use" and "I feel that the back skin is not tight after use". More than 90% of the subjects gave positive comments on product satisfaction.

3. Semi-quantitative evaluation (doctor's evaluation) showed that after the subjects used the product, the ISGA score showed a downward trend at the follow-up time point D28, which was significantly different from the baseline value.

4. Analysis of the average volume of acne showed that after the subjects used the product, the average volume of acne showed a downward trend at the follow-up time point D28, which was significantly different from the baseline value.

5. Analysis of the oil content on the skin surface showed that after the subjects used the product, the oil content on the skin surface showed a downward trend at the follow-up time point D28, which was significantly different from the baseline value.

In summary, after using the Beauti Oil Control Anti-Acne Shower Gel for 28 days, the ISGA score can be reduced, the overall acne lesions on the back can be improved, the average volume of acne on the back can be reduced, the oil content on the back can be reduced, and the acne and oil control effects can be achieved. In the subjective evaluation, more than 50% of the subjects gave positive comments on the product's skin feel, acne removal, oil control effects, mildness and satisfaction, indicating that the product has acne removal and oil control effects.

Although the present invention is described in detail with reference to the above embodiments, it is obvious to those skilled in the art through this disclosure that various changes or modifications may be made to the present invention without departing from the principle and spirit of the present invention as defined by the claims. Therefore, the detailed description of the embodiments of the present disclosure is only used to explain, not to limit the present invention, but the scope of protection is limited by the content of the claims.

Claims (7)

An oil-controlling and acne-removing shower gel is characterized in that it comprises the following raw material components by weight percentage: 10-18% surfactant, 0.3-1% thickener, 0.5-2% sodium chloride, 0.05-0.2% pH regulator, 0.1-0.6% azelaic acid, 0.1-0.5% capryloyl glycine, 0.1-0.6% plant acaricide, 0.2-2% sophora flavescens extract, 0.01-0.1% epilobium fleischer extract, 0.1-0.5% carbohydrate isomer mixture, 0.1-0.5% sodium ascorbyl phosphate, 0.5-1.5% tremella extract, 0.01-0.2% gentian extract, 0.3-0.7% preservative and balance water. The oil-control and acne-removing shower gel according to claim 1, characterized in that the surfactant is composed of sodium laureth sulfate, sodium methyl cocoyl taurate, cocamidopropyl betaine, sodium lauroamphoacetate, and cocamide methyl MEA. The oil-control and acne-removing shower gel according to claim 1 is characterized in that the plant mite remover consists of thyme extract, rosemary water, 1,3-propylene glycol, dichlorobenzyl alcohol, and phenoxyethanol. The oil-control and acne-removing shower gel according to claim 1, characterized in that the thickener consists of tocopherol and PEG-120 methyl glucose dioleate. The oil-controlling and anti-acne shower gel according to claim 1 is characterized in that the carbohydrate isomer mixture comprises carbohydrate isomers, water, citric acid and sodium citrate. The oil-controlling and anti-acne shower gel according to claim 1, characterized in that the pH regulator is potassium hydroxide. The preparation method of the oil-controlling and acne-removing shower gel according to claim 1 comprises the following steps: S1: Divide the water into two parts, put the first part of water into the production pot, heat it to 80-85℃, add surfactant and stir until it is evenly dissolved; S2: Continue to add thickener, azelaic acid, and capryloyl glycine into the production pot and stir until they are evenly dissolved; S3: Cool down to 45°C, add plant acaricide, Sophora flavescens extract, pH adjuster, sugar isomer mixture, sodium ascorbyl phosphate, Tremella fuciformis extract, Gentiana scabra extract, and Epilobium freiherb extract, and stir to dissolve evenly; S4: Sodium chloride is first completely dissolved with the second part of water and then put into the production pot and stirred evenly, and the pH and viscosity are adjusted and the material is discharged.