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WO2024259190A3 - 5'-modified monomers, oligonucleotides and double-stranded rnas - Google Patents

5'-modified monomers, oligonucleotides and double-stranded rnas Download PDF

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Publication number
WO2024259190A3
WO2024259190A3 PCT/US2024/033953 US2024033953W WO2024259190A3 WO 2024259190 A3 WO2024259190 A3 WO 2024259190A3 US 2024033953 W US2024033953 W US 2024033953W WO 2024259190 A3 WO2024259190 A3 WO 2024259190A3
Authority
WO
WIPO (PCT)
Prior art keywords
oligonucleotides
double
stranded rnas
modified monomers
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/033953
Other languages
French (fr)
Other versions
WO2024259190A2 (en
Inventor
Juan SALINAS
Dhrubajyoti Datta
Muthiah Manoharan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alnylam Pharmaceuticals Inc
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of WO2024259190A2 publication Critical patent/WO2024259190A2/en
Publication of WO2024259190A3 publication Critical patent/WO2024259190A3/en
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The technology described herein relates to 5'-modified nucleosides, nucleotides, oligonucleotides and double-stranded RNAs, e.g., siRNAs, and kits comprising them and methods of their use for inhibiting target genes.
PCT/US2024/033953 2023-06-15 2024-06-14 5'-modified monomers, oligonucleotides and double-stranded rnas Pending WO2024259190A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363521256P 2023-06-15 2023-06-15
US63/521,256 2023-06-15

Publications (2)

Publication Number Publication Date
WO2024259190A2 WO2024259190A2 (en) 2024-12-19
WO2024259190A3 true WO2024259190A3 (en) 2025-03-27

Family

ID=93852914

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/033953 Pending WO2024259190A2 (en) 2023-06-15 2024-06-14 5'-modified monomers, oligonucleotides and double-stranded rnas

Country Status (1)

Country Link
WO (1) WO2024259190A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100104532A1 (en) * 2007-02-09 2010-04-29 Gilead Sciences, Inc. Nucleoside analogs for antiviral treatment
US20190177729A1 (en) * 2016-09-02 2019-06-13 Dicerna Pharmaceuticals, Inc. 4'-phosphate analogs and oligonucleotides comprising the same
WO2023069495A1 (en) * 2021-10-19 2023-04-27 Alnylam Pharmaceuticals, Inc. Oligonucleotides with 2'-deoxy-2'-f-2'-c-methyl nucleotides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100104532A1 (en) * 2007-02-09 2010-04-29 Gilead Sciences, Inc. Nucleoside analogs for antiviral treatment
US20190177729A1 (en) * 2016-09-02 2019-06-13 Dicerna Pharmaceuticals, Inc. 4'-phosphate analogs and oligonucleotides comprising the same
WO2023069495A1 (en) * 2021-10-19 2023-04-27 Alnylam Pharmaceuticals, Inc. Oligonucleotides with 2'-deoxy-2'-f-2'-c-methyl nucleotides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE PUBCHEM SUBSTANCE 9 April 2016 (2016-04-09), XP093296030, Database accession no. 312898048 *

Also Published As

Publication number Publication date
WO2024259190A2 (en) 2024-12-19

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