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WO2024259154A3 - A rapid microfluidic in vivo bioassay for screening functional ingredients for improving gut health - Google Patents

A rapid microfluidic in vivo bioassay for screening functional ingredients for improving gut health Download PDF

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Publication number
WO2024259154A3
WO2024259154A3 PCT/US2024/033889 US2024033889W WO2024259154A3 WO 2024259154 A3 WO2024259154 A3 WO 2024259154A3 US 2024033889 W US2024033889 W US 2024033889W WO 2024259154 A3 WO2024259154 A3 WO 2024259154A3
Authority
WO
WIPO (PCT)
Prior art keywords
functional ingredients
vivo bioassay
gut health
improving gut
screening functional
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/033889
Other languages
French (fr)
Other versions
WO2024259154A2 (en
Inventor
M. Adnan QURESHI
Mizanur Rahman
Taslim ANUPOM
Kylie L. HARMAN
Dhaval Subhas PATEL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nemalife Inc
Original Assignee
Nemalife Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nemalife Inc filed Critical Nemalife Inc
Publication of WO2024259154A2 publication Critical patent/WO2024259154A2/en
Publication of WO2024259154A3 publication Critical patent/WO2024259154A3/en
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5085—Supracellular entities, e.g. tissue, organisms of invertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43526—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms
    • G01N2333/4353—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from nematodes
    • G01N2333/43534—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from nematodes from Caenorhabditis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medical Informatics (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Databases & Information Systems (AREA)
  • Data Mining & Analysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Primary Health Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Provided herein are systems and methods for a rapid microfluidic in vivo bioassay for screening functional ingredients for improving gut health. An AI model is also described that enables the automated detection of leaky gut and health gut in C. elegans.
PCT/US2024/033889 2023-06-13 2024-06-13 A rapid microfluidic in vivo bioassay for screening functional ingredients for improving gut health Pending WO2024259154A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363507975P 2023-06-13 2023-06-13
US63/507,975 2023-06-13

Publications (2)

Publication Number Publication Date
WO2024259154A2 WO2024259154A2 (en) 2024-12-19
WO2024259154A3 true WO2024259154A3 (en) 2025-04-24

Family

ID=93852899

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/033889 Pending WO2024259154A2 (en) 2023-06-13 2024-06-13 A rapid microfluidic in vivo bioassay for screening functional ingredients for improving gut health

Country Status (1)

Country Link
WO (1) WO2024259154A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10668467B2 (en) * 2015-06-10 2020-06-02 Texas Tech University System Microfluidic device for studying nematodes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10668467B2 (en) * 2015-06-10 2020-06-02 Texas Tech University System Microfluidic device for studying nematodes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GELINO SARA, CHANG JESSICA T., KUMSTA CAROLINE, SHE XINGYU, DAVIS ANDREW, NGUYEN CHRISTIAN, PANOWSKI SILER, HANSEN MALENE: "Intestinal Autophagy Improves Healthspan and Longevity in C. elegans during Dietary Restriction", PLOS GENETICS, vol. 12, no. 7, US , pages e1006135 - e1006135-12, XP093307693, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1006135 *
KIM JUIL, MOON YUSEOK: "Worm-Based Alternate Assessment of Probiotic Intervention against Gut Barrier Infection", NUTRIENTS, vol. 11, no. 9, CH , pages 2146 - 2146-13, XP093307688, ISSN: 2072-6643, DOI: 10.3390/nu11092146 *
KINGSLEY SAMUEL F., SEO YONGHAK, WOOD ALICIA, WANI KHURSHEED A., GONZALEZ XAVIER, IRAZOQUI JAVIER, FINKEL STEVEN E., TISSENBAUM HE: "Glucose-fed microbiota alters C. elegans intestinal epithelium and increases susceptibility to multiple bacterial pathogens", SCIENTIFIC REPORTS, vol. 14, no. 1, US , pages 1 - 12, XP093307698, ISSN: 2045-2322, DOI: 10.1038/s41598-024-63514-w *
NEMALIFE: "NemaLife Files a Novel Gut Health Bioassay Patent to Aid the Discovery of Functional Ingredients", HTTPS://WWW.NEMALIFEINC.COM, NEMALIFE, 6 September 2023 (2023-09-06), pages 1 - 2, XP093307701, Retrieved from the Internet <URL:https://www.nemalifeinc.com/post/nemalife-files-a-novel-gut-health-bioassay-patent-to-aid-the-discovery-of-functional-ingredients> *
ZHANG XUFEI, MONNOYE MAGALI, MARIADASSOU MAHENDRA, BEGUET-CRESPEL FABIENNE, LAPAQUE NICOLAS, HEBERDEN CHRISTINE, DOUARD VERONIQUE: "Glucose but Not Fructose Alters the Intestinal Paracellular Permeability in Association With Gut Inflammation and Dysbiosis in Mice", FRONTIERS IN IMMUNOLOGY, vol. 12, CH, pages 742584 - 742584-17, XP093307696, ISSN: 1664-3224, DOI: 10.3389/fimmu.2021.742584 *

Also Published As

Publication number Publication date
WO2024259154A2 (en) 2024-12-19

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