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WO2024258995A3 - Fused tetrahydroazepine psychoplastogens and uses thereof - Google Patents

Fused tetrahydroazepine psychoplastogens and uses thereof Download PDF

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Publication number
WO2024258995A3
WO2024258995A3 PCT/US2024/033653 US2024033653W WO2024258995A3 WO 2024258995 A3 WO2024258995 A3 WO 2024258995A3 US 2024033653 W US2024033653 W US 2024033653W WO 2024258995 A3 WO2024258995 A3 WO 2024258995A3
Authority
WO
WIPO (PCT)
Prior art keywords
fused
psychoplastogens
tetrahydroazepine
disorders
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/033653
Other languages
French (fr)
Other versions
WO2024258995A2 (en
Inventor
Milan Chytil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Delix Therapeutics Inc
Original Assignee
Delix Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delix Therapeutics Inc filed Critical Delix Therapeutics Inc
Publication of WO2024258995A2 publication Critical patent/WO2024258995A2/en
Publication of WO2024258995A3 publication Critical patent/WO2024258995A3/en
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Disclosed herein are compounds, compositions, and methods for promoting neuronal growth and/or improving neuronal structure with the compounds and compositions disclosed herein. Also described are methods of treating diseases or disorders that are mediated by the loss of synaptic connectivity and/or plasticity, such as neurological diseases and disorders, with fused tetrahydroazepine or fused piperidine psychoplastogens.
PCT/US2024/033653 2023-06-13 2024-06-12 Fused tetrahydroazepine psychoplastogens and uses thereof Pending WO2024258995A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363507964P 2023-06-13 2023-06-13
US63/507,964 2023-06-13

Publications (2)

Publication Number Publication Date
WO2024258995A2 WO2024258995A2 (en) 2024-12-19
WO2024258995A3 true WO2024258995A3 (en) 2025-04-10

Family

ID=93852872

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/033653 Pending WO2024258995A2 (en) 2023-06-13 2024-06-12 Fused tetrahydroazepine psychoplastogens and uses thereof

Country Status (1)

Country Link
WO (1) WO2024258995A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040209870A1 (en) * 2000-03-14 2004-10-21 Ennis Michael Dalton Novel 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole compounds
US20060154944A1 (en) * 2003-06-23 2006-07-13 Kazuyuki Ohmoto Novel tricyclic heterocycle compound
US20140163012A1 (en) * 2012-12-11 2014-06-12 Albany Molecular Research, Inc. Pyrido-/azepino-benzofuran and pyrido-/azepino-benzothiophene mch-1 antagonists, methods of making, and use thereof
US20170183419A1 (en) * 2009-02-05 2017-06-29 Immunogen, Inc. Novel benzodiazepine derivatives
WO2022170268A1 (en) * 2021-02-08 2022-08-11 The Trustees Of Columbia University In The City Of New York Oxa-ibogaine inspired analogues for treatment of neurological and psychiatric disorders

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040209870A1 (en) * 2000-03-14 2004-10-21 Ennis Michael Dalton Novel 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole compounds
US20060154944A1 (en) * 2003-06-23 2006-07-13 Kazuyuki Ohmoto Novel tricyclic heterocycle compound
US20170183419A1 (en) * 2009-02-05 2017-06-29 Immunogen, Inc. Novel benzodiazepine derivatives
US20140163012A1 (en) * 2012-12-11 2014-06-12 Albany Molecular Research, Inc. Pyrido-/azepino-benzofuran and pyrido-/azepino-benzothiophene mch-1 antagonists, methods of making, and use thereof
WO2022170268A1 (en) * 2021-02-08 2022-08-11 The Trustees Of Columbia University In The City Of New York Oxa-ibogaine inspired analogues for treatment of neurological and psychiatric disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE PUBCHEM 25 October 2006 (2006-10-25), DOWNLOAD CITE: "3-Methyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole", XP093302495, retrieved from PUBCHEM COMPOUND Database accession no. 9920667 *

Also Published As

Publication number Publication date
WO2024258995A2 (en) 2024-12-19

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