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WO2024256275A1 - Dispositif de maintien pour dispositifs de distribution pour la distribution de substances d'au moins une substance efficace sur le plan thérapeutique et/ou diagnostique - Google Patents

Dispositif de maintien pour dispositifs de distribution pour la distribution de substances d'au moins une substance efficace sur le plan thérapeutique et/ou diagnostique Download PDF

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Publication number
WO2024256275A1
WO2024256275A1 PCT/EP2024/065687 EP2024065687W WO2024256275A1 WO 2024256275 A1 WO2024256275 A1 WO 2024256275A1 EP 2024065687 W EP2024065687 W EP 2024065687W WO 2024256275 A1 WO2024256275 A1 WO 2024256275A1
Authority
WO
WIPO (PCT)
Prior art keywords
dispensing
holding device
substance
dispensing devices
holding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2024/065687
Other languages
English (en)
Inventor
Olaf LEBAU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of WO2024256275A1 publication Critical patent/WO2024256275A1/fr
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3137—Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3137—Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
    • A61M2005/3139—Finger grips not integrally formed with the syringe barrel, e.g. using adapter with finger grips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/586—Ergonomic details therefor, e.g. specific ergonomics for left or right-handed users

Definitions

  • Holding device for dispensing devices for substance dispensing of at least one therapeutically and/or diagnostically effective substance
  • the invention relates to a holding device for a substance dispensing device, in particular for an autoinjector, for substance dispensing of at least one therapeutically and/or diagnostically effective substance.
  • the holding device is held by hand during substance dispensing and/or is configured and dimensioned for manual use.
  • the present invention relates to an arrangement with a holding device and with a substance dispensing device, in particular an autoinjector, for substance dispensing of at least one therapeutically and/or diagnostically effective substance.
  • the invention further relates to the use of a holding device for holding at least one substance dispensing device, in particular an autoinjector, for substance dispensing of at least one therapeutically and/or diagnostically effective substance.
  • the invention relates to a method for the multiple application of a therapeutically and/or diagnostically effective substance by substance dispensing via two or more substance dispensing devices, in particular via two or more autoinjectors.
  • the invention relates to the handling and/or use of dispensing devices for substance dispensing of therapeutically and/or diagnostically effective/active substances.
  • Substance dispensing devices are known from the state of the art which are structurally and functionally configured and embodied for self-sufficient substance dispensing.
  • the dispensing device has a structural unit which is configured and embodied for substance dispensing in a structurally and functionally independent manner.
  • the dispensing device has an outer housing so that the dispensing device can be held via the outer housing and independently of a separate holding device during substance dispensing and can be positioned and handled relative to a substance dispensing site, in particular an injection site of a patient.
  • the dispensing device comprises a trigger mechanism in order to cause a substance dispensing and/or substance discharge independently after the activation of an actuator of the trigger mechanism.
  • the dispensing device may comprise an assembly integrated or encap- sulated/enclosed in the dispensing device for needle-assisted or needle-free substance dispensing to a patient.
  • a housing of the dispensing device can be a functional part of the assembly, i.e. interact mechanically and functionally with other parts of the assembly during injection, or merely serve to enclose/encase the assembly and for handling the assembly during substance dispensing.
  • the dispensing device is designed and functionalized for a single injection of a therapeutically and/or diagnostically effective substance.
  • the use of dispensing devices which are designed and functionalized for multiple substance dispensing, in particular multiple injections, is not excluded.
  • the dispensing device can be in particular an autoinjector.
  • Suitable autoinjectors that can be used within the scope of the invention are described, for example, in EP 2 742 962 A2, EP 2 745 866 A1 or also CH 711 066 A2.
  • the aforementioned documents describe autoinjectors that are configured and functionalized for self-sufficient substance dispensing and can be used within the scope of the invention.
  • EP 2 742 962 A2 describes an autoinjector configured for self-sufficient substance dispensing, which comprises a device for generating an acoustic and/or tactile signal.
  • the autoinjector has a sleeve-shaped, elongated housing with a longitudinal axis, which has a closing cap at its proximal end, i.e. its rear end or end opposite an injection needle of the autoinjector, which cap is connected to the housing in a form-fitting manner in a rotationally and axially fixed manner and forms the proximal end of the autoinjector.
  • a pull-off cap can be arranged at the distal, front end of the known autoinjector in its as-delivered state, which is pulled off or twisted off and removed before the autoinjector is used.
  • a product container in the shape of a syringe can be accommodated in the housing of the autoinjector so that it is immovable along the longitudinal axis.
  • the product container can have a sleeve-shaped syringe body I syringe barrel that surrounds a plunger or piston that lies sealingly against the inner circumference of the syringe body.
  • the syringe body can have an injection needle which is in particular non-detachably connected to the syringe body, the distal end of the injection needle being formed by the needle tip.
  • a liquid substance in particular a medication/medicine, can be arranged within the syringe body between the injection needle and the plunger or piston, wherein the substance is discharged/dis-claimedd out of the syringe body through the injection needle by displacing the plunger or piston in a distal dispensing and/or discharge direction towards the injection needle.
  • the syringe body can be arranged in relation to the housing such that the needle tip protrudes distally beyond the distal end of the housing.
  • a needle protection cap which is embodied as a so-called rigid needle shield, alternatively soft needle shield, known to the skilled person, in order to protect the needle from contamination and to keep the substance inside the syringe body sterile.
  • the needle protection cap is arranged on a needle holding portion of the syringe body, wherein the pull-off cap is releasably snapped to the housing or to an axially displaceable needle protection sleeve forming an actuator for triggering the substance dispensing, and wherein this snapping is released when the pull-off cap is removed from the housing or the needle protection sleeve.
  • the needle protection sleeve is displaceable relative to the housing and along the longitudinal axis by an actuating stroke in a proximal direction into an actuated position in order to activate a trigger mechanism and trigger a substance discharge.
  • the distal end of the needle protection sleeve protrudes distally over the needle tip of the needle, so that access to the needle tip is initially prevented.
  • the needle protection sleeve By displacing the needle protection sleeve by an actuation stroke in the proximal direction, the needle protection sleeve is moved so far proximally that the needle protrudes from the distal end of the needle protection sleeve, which corresponds to the injection depth of the needle into a puncture site of a patient.
  • the needle protrudes beyond the distal end of the needle protection sleeve in such a way that a subcutaneous injection can take place.
  • the housing can form a stop against which the needle protection sleeve rests in the actuated position.
  • the pull-off cap described at the beginning has a snatch/catch which engages in a gap between the syringe body, in particular its tapering region, and the proximal end of the needle protection cap.
  • the pull-off cap is pulled-off from the known autoinjector together with the needle protection cap.
  • the distal end of the needle protection sleeve is placed against the puncture site of a patient, wherein the housing is displaced towards the puncture site so that the needle protection sleeve moves from its initial position by an actuating stroke in a proximal direction relative to the housing into an actuated position.
  • This actuates and/or activates a trigger mechanism which leads to the substance discharge.
  • the disclosure of the trigger mechanism described in EP 2 742 962 A2 is incorporated into the disclosure content of the present description of the invention.
  • the needle protection sleeve can be moved relative to the housing from an actuated position along the longitudinal axis of the housing by a needle protection stroke in the distal direction into a needle protection position.
  • the needle protection position the distal end of the needle protection sleeve then protrudes distally over the needle tip, so that access to the needle tip can be prevented and the risk of injury can be reduced.
  • the needle protection sleeve can be blocked against being moved back out of the needle protection position.
  • the autoinjector known from EP 2 742 962 A2 represents an exemplary embodiment of autoinjectors which are configured and functionalized for self-sufficient substance dispensing.
  • Such autoinjectors form an integral structural unit and/or comprise such a structural unit, wherein an assembly of the autoinjector required for substance dispensing can be integrated in an outer housing of the autoinjector.
  • An autoinjector embodied in this way is commercially available as a standard autoinjector and is usually held manually for substance dispensing and/or substance discharge and moved in the direction of the injection site on the patient in order to effect automatic substance discharge from the product container of the autoinjector by contact of the actuator, for example the needle protection sleeve of the autoinjector known from EP 2 742 962 A2.
  • a structural unit integrated into the housing of the autoinjector is constructed and functionalized in a corresponding manner.
  • an autoinjector of the type described in EP 2 742 962 A2 relates to a preferred embodiment of dispensing devices which can be used in connection with the teaching according to the invention, the invention is not limited to the use of such autoinjectors.
  • Dispensing devices which differ in construction and function from the construction and function described in EP 2 742 962 A2, but which are configured and embodied for self-sufficient substance dispensing, can also be advantageously used within the scope of the invention.
  • holding devices are already known from the prior art for holding and/or fastening only one dispensing device to the holding device and, in the state of holding, for substance dispensing via the dispensing device held on the holding device.
  • Such holding devices are usually used with the aim of simplifying the handling of the dispensing device for the user of the dispensing device during substance dispensing, in particular during substance injection into the body of a patient, in particular to ensure a high level of user comfort when using the dispensing device.
  • such single holders can have certain surface geometries optimized from an ergonomic point of view and/or certain surface structures to improve the haptic perception of the surface when using the single holder, such as surfaces made of soft, elastic plastics, heat-generating materials or materials that improve static friction, for example.
  • the external appearance and/or design of the single holder may be intended to provide an aesthetically pleasing external appearance to the composite of single holder and dispensing device.
  • the single holder may be personalized for use by a particular user and may include means for storing and/or reproducing and/or displaying data and information associated with the user.
  • the holder can also be configured and embodied to measure temperature, time or body function values, such as blood glucose, and have corresponding measuring devices for this purpose.
  • the external appearance and shape of the single holder makes it possible to distinguish a dispensing device connected to the single holder with regard to the type and composition of a substance to be dispensed and/or with regard to a specific dispensing volume of the dispensing device from dispensing devices with a different substance and/or different dispensing volume, thus providing an easily recognizable distinguishing means for distinguishing different dispensing devices.
  • a holding device embodied as a single holder with a medicament delivery device
  • the medicament delivery device is an autoinjector.
  • the holding device has a shell part with an entry passage via which the autoinjector is introduced into the shell part and then held in the shell part.
  • a further shell part serves as a closure element that is connected to the first shell part and thus closes the entry passage.
  • the autoinjector is then held between the two shell parts and fixed to the shell parts via fixing elements.
  • a holding device for a syringe which is intended to simplify the handling of the syringe during injection and has a shell housing formed by two half-shell parts that are connected to each other in a foldable manner. In the functional state, the syringe is then arranged between the half-shell parts which are folded onto each other.
  • EP 0 014 006 B1 discloses an injecting device comprising an outer housing assembly, wherein a first cartridge sub-assembly and a second cartridge sub-assembly are arranged within the outer housing assembly.
  • the outer housing assembly comprises two housing halves that are connected to one another by rivets.
  • US 2005/0203464 A1 discloses a medical injection apparatus for simultaneously administering two or more medications.
  • the apparatus comprises a housing that is structured to hold two or more syringes in a fixed relationship.
  • the housing comprises two portions, each portion defining half of the housing, wherein the first portion and the second portion are connected to one another by means of a hinge assembly.
  • WO 2018/078121 A1 discloses an injecting device for simultaneous administration of several medications, wherein the injection device comprises a carrying housing and two carpules arranged therein.
  • Object of the present invention is to provide a holding device for a dispensing device for substance dispensing of therapeutically and/or diagnostically effective substances, which is characterized by an extended functionality compared to the known single holders.
  • the holding device shall be suitable for use with at least one substance dispensing device which is configured and functionalized for self-sufficient substance dispensing, in particular for substance dispensing independently of the holding device.
  • Further objects of the invention are to provide a new and advantageous use of a holding device for holding a substance dispensing device before, during and/or after a substance dispensing and an improved method for multiple application of a therapeutically and/or diagnostically effective substance by substance dispensing via multiple dispensing devices.
  • the holding device according to the invention shall meet high requirements for simplified handling of the dispensing device during substance dispensing and for the external appearance and/or design of the arrangement formed by the holding device and dispensing device.
  • the holding device according to the invention shall in particular enable a larger, in particular multiple, substance dispensing in a simple manner compared to substance dispensing with only one dispensing device, in particular without having to increase the construction of the dispensing device for this purpose, in particular the size of a volume reservoir of the dispensing device for a therapeutically and/or diagnostically effective substance.
  • a holding device with the features of claim 1 , by an arrangement with a holding device and with at least one dispensing device according to claim 13, by using a holding device for holding at least one dispensing device according to claim 14 or by a method for multiple application of a therapeutically and/or diagnostically effective substance with the features of claim 15.
  • Advantageous embodiments of the invention are the subject of the sub-claims.
  • a holding device is proposed according to the invention as a multi-holder for holding and/or fastening/fixing two or more dispensing devices, in particular for holding two or more autoinjectors, on the multiholder, in particular in a form-fitting and/or force-fitting manner, possibly also in a substance-fitting I bonding manner.
  • the holding device is embodied and configured for substance dispensing via at least one dispensing device held on the holding device, in particular for substance dispensing via a plurality of dispensing devices held on the holding device, further in particular for substance dispensing via all dispensing devices held on the holding device, in relation to the state of holding the at least one dispensing device on the holding device.
  • the invention relates to holding devices, in particular for holding multiple dispensing devices, such as autoinjectors.
  • the holding device according to the invention is intended for use with dispensing devices which are embodied for self-sufficient substance dispensing.
  • the dispensing device comprises and/or forms a structural unit which is configured and functionalized for self-sufficient substance dispensing.
  • the dispensing device is then embodied for substance dispensing independently of the holding device according to the invention, so that a use of the dispensing device for substance dispensing is also possible in a separate state from the holding device.
  • the holding device according to the invention represents a separate application aid when using multiple dispensing devices.
  • a structural and functional design of the holding device according to the invention is provided in such a way that a substance dispensing can take place via at least one dispensing device connected to and/or held by the holding device according to the invention, in particular via multiple connected and/or held dispensing devices, further in particular via all connected and/or held dispensing devices, without having to interrupt the connection spatially and/or functionally. Substance dispensing is thus possible when the respective dispensing device is held on the holding device according to the invention.
  • the substance dispensing device is then manually held via the multi-holder according to the invention and positioned relative to the patient.
  • the holding device according to the invention allows two or more substance dispensing devices, in particular multiple autoinjectors, to be held simultaneously in a simple manner by the user's hand and positioned relative to the patient.
  • a suitable external geometry and/or shape of the holding device according to the invention ensures a high level of user comfort when handling multiple dispensing devices, in particular for persons with motor impairments. This applies in particular to autoinjectors, which have an elongated, slim housing that can often only be held, in particular by persons with motor impairments, with limited positional accuracy relative to the patient's body during medication dispensing.
  • a good tactile perception of the holding device can be achieved, in particular during substance dispensing, which further increases user comfort and simplifies the precise positioning of the held dispensing devices relative to the patient.
  • the external appearance of known substance dispensing devices is generally determined primarily from a functional point of view, which limits the freedom of design when designing the external appearance of the substance dispensing devices. In contrast, there is a high degree of design freedom when determining the external appearance of the holding device according to the invention, so that individual design requirements can be met in a simple manner.
  • each substance dispensing device has an assembly integrated and/or encapsulated/enclosed in an outer housing of the substance dispensing device for needle-assisted or needle-free substance dispensing to a patient.
  • the housing can be a functional part of the assembly, i.e. it can interact mechanically with other parts of the assembly during substance discharge, or it can merely serve to enclose/en- case the assembly.
  • the dispensing device Via the housing of the dispensing device, the dispensing device can be handled and/or held manually and positioned relative to the body of a patient in the state when the dispensing device is not connected to the holding device according to the invention and/or is not held on the holding device.
  • the dispensing device thus is designed to be independently functional.
  • a second aspect of the invention relates to an arrangement with a holding device described above and with at least one dispensing device, in particular an autoinjector, for substance dispensing of at least one therapeutically and/or diagnostically effective substance, in particular with two or more dispensing devices, in particular wherein the or each dispensing device is a structural unit configured and functionalized for self-sufficient substance dispensing and/or in particular wherein the or each dispensing device is configured and functionalized for single injection.
  • a third aspect of the invention relates in particular also to the use of a holding device of the type described above for holding at least one dispensing device for substance dispensing of at least one therapeutically and/or diagnostically effective substance, in particular for holding at least one autoinjector, further in particular for holding two or more dispensing devices, in particular wherein the or each dispensing device is a structural unit configured and functionalized for self-sufficient substance dispensing and/or in particular wherein the dispensing device is configured and functionalized for single injection.
  • the fourth aspect of the present invention relates to the use of a holding device embodied as a multi-holder for simultaneous, in particular synchronous, substance dispensing via two or more dispensing devices held on the multi-holder, in particular two or more autoinjectors.
  • a fifth aspect of the present invention relates to a method for multiple application of a therapeutically and/or diagnostically effective substance by substance dispensing via two or more dispensing devices, in particular via two or more autoinjectors, in particular wherein each dispensing device forms and/or comprises a structural unit which is configured and functionalized for self-sufficient substance dispensing and/or in particular wherein each dispensing device is configured and functionalized for single injection.
  • the dispensing devices are connected to a multi-holder, in particular a multi-holder of the type described above, before the multiple application and are then held on the multi-holder in the connected state.
  • the substance dispensing is then carried out, in particular simultaneously, further in particular synchronously, via the dispensing devices.
  • the holding device is embodied for simultaneous substance dispensing via the dispensing devices on the same application plane of the dispensing devices when multiple dispensing devices are held on the multi-holder according to the invention.
  • the substance dispensing then takes place at the same application plane of the dispensing devices. This requires a certain arrangement of the dispensing devices relative to one another, which is predetermined by the construction and/or design of the holding device.
  • Each substance dispensing device can, for example, comprise an actuator at the distal end facing the patient, which activates a trigger mechanism of the dispensing device and the substance dispensing, when the actuator is pressed against a dose dispensing site and/or the skin of a patient.
  • the holding device according to the invention I the multi-holder according to the invention can then be embodied in such a way that the actuators of multiple, in particular of all, substance dispensing devices connected to the holding device according to the invention lie in the same application plane at least when the actuators are pressed against the dose dispensing site, preferably always.
  • application plane can refer to end-face proximal outer surfaces of the actuators, which lie in a common skin contact plane and, for activation of the substance dispensing, for example in the case of autoinjectors by triggering a trigger mechanism of the type described in EP 2 745 866 A1 , simultaneously come into contact with the patient's skin when moving in the direction of the dose dispensing site and simultaneously trigger the trigger mechanism of the plurality of dispensing devices.
  • the holding device according to the invention can be embodied in particular for simultaneously holding multiple dispensing devices of the same design/shape and/or having the same substance discharge volume.
  • the preferably simultaneous holding of dispensing devices which contain a different discharge volume and/or a different therapeutically and/or diagnostically effective substance is also not excluded.
  • the holding device may have a holder housing embodied for holding and, in particular, for at least partially enclosing/encasing a plurality of dispensing devices, further embodied in particular for enclosing/encasing at least a major part or majority of the held dispensing devices.
  • the terms “major part” or “majority” refer to a larger proportion of the volume and/or surface area of the dispensing devices enclosed in the holding device.
  • the holding device can have a holder housing which is formed by and/or comprises a plurality of shell parts, in particular two half-shell parts connected indirectly and/or directly to one another, in particular via a clamping connection and/or latching connection, further in particular wherein at least one grip shell part is provided which is U-shaped in cross-section and has a curved inner side which is adapted to the shape of the connected half-shell parts, in particular in order to be brought into releasable or non-releasable clamping engagement with the connected half-shell parts.
  • the holder housing and/or the interacting shell parts can form a multi-chamber system, for example a double chamber, in order to accommodate/receive multiple substance dispensing devices, in particular multiple autoinjectors, and to hold them for substance dispensing in a fixed position on the holding device according to the invention.
  • Fig. 2 a top view of the holder housing from Fig. 1 in the assembled state
  • Fig. 3 a side view of the holder housing from Fig. 1 in the assembled state
  • Fig. 6 a top view of the arrangement from Fig. 5,
  • Fig. 7 a side view of the arrangement from Fig. 5,
  • Fig. 8 a perspective view of the arrangement from Fig. 5 after the pull-off cap has been pulled off from the dispensing devices
  • Fig. 9 a perspective view of another embodiment of an arrangement according to the invention, comprising a holding device according to the invention with a holder housing in a pre-assembled state of the holder housing and with a pull-off cap for connection to two dispensing devices for a therapeutically and/or diagnostically effective substance held in the holding device,
  • Fig. 10 a perspective view of the arrangement from Fig. 9 in an assembled state of the holder housing
  • Fig. 11 a side view of the holder housing from Fig. 10,
  • Fig. 12 an enlarged partial view of the distal, front end of the holder housing from Fig. 11 and
  • Fig. 13 an enlarged partial view of the proximal, rear end of the holder housing from Fig. 11 .
  • Figs. 1 to 4 show a holding device 1 embodied as a multi-holder for dispensing devices 2, for example autoinjectors, further for example autoinjectors of the type described in EP 2 742 962 A2. It is understood that all the features, aspects, characteristics, and advantages described below are not limited to the embodiment of the holding device 1 and of an arrangement of the holding device 1 with two dispensing devices 2 shown in the figures and described. This concerns the construction and/or design of the holding device 1 and/or the dispensing devices 2.
  • the dispensing devices 2 are embodied and functionalized for substance dispensing at least one therapeutically and/or diagnostically effective substance.
  • the holding device 1 is held by hands I manually and is moved and/or guided to a dispensing site, in particular an injection site, on a patient.
  • Each dispensing device 2 is preferably embodied and functionalized for self-sufficient and/or autonomous substance dispensing independently of the holding device 1 and comprises or forms a structural unit configured for this purpose. Each dispensing device 2 can then be used as such autonomously and independently of the holding device 1 for substance dispensing.
  • the term "self-sufficient substance dispensing” refers to a state prior to the connection of the dispensing device 2 to and/or the holding of the dispensing device 2 on the holding device 1.
  • the dispensing device 2 is embodied and configured autonomously and independently of the holding device 1 for functionally independent substance dispensing, which relates to the construction of the dispensing device 2 and in particular its trigger mechanism for triggering substance dispensing.
  • the dispensing device 2 can, in particular, be used and deployed for dispensing substances independently of the holding device 1 according to the invention.
  • the dispensing device 2 may have a housing 5 in which an assembly for needle-assisted or needle-free substance dispensing to a patient is integrated.
  • the assembly may be encapsulated in the housing 5.
  • the housing 5 can be a functional part of the assembly, i.e. interact mechanically and/or functionally with other parts of the assembly during substance dispensing, or can merely serve to enclose the assembly.
  • the holding device 1 can also be embodied and functionally configured as a multi-holder for dispensing devices which differ in construction and/or function from the constructive design shown in parts in Fig. 8 and from the design of the dispensing device described in detail in EP 2 742 962 A2.
  • the dispensing devices 2 each have an actuator 3 (Fig. 8) at the distal front end as part of a trigger mechanism for automatic substance dispensing.
  • the holding device 1 is embodied as a multi-holder for holding a plurality of dispensing devices 2 and, in the state of holding a plurality of dispensing devices 2 on the holding device 1 , for substance dispensing via at least one dispensing device 2 held on the holding device 1 .
  • the holding device 1 is embodied for holding two dispensing devices 2 and for substance dispensing via both dispensing devices 2 held on the holding device 1.
  • the dispensing devices 2 are fixed and/or stationary on the holding device 1 , so that substance dispensing via at least one dispensing device 2, in the embodiment shown simultaneously via both dispensing devices 2, is possible in the holding state.
  • the construction of the holding device 1 permits substance dispensing via at least one dispensing device 2, preferably via multiple dispensing devices 2, in the embodiment shown via both dispensing devices 2, without these having to be separated from the holding device 1.
  • the holding device 1 then serves as an application aid during substance dispensing via the dispensing devices 2 to a patient.
  • the holding device 1 can be used in an advantageous manner for substance dispensing via multiple dispensing devices 2, wherein the dispensing devices 2 are held in the holding state on the holding device 1 before, during and/or after substance dispensing and, in particular, can be positioned relative to a patient and/or to an injection site.
  • the holding device 1 allows the volume dispensing to be multiplied when using multiple dispensing devices 2.
  • the shape of the holding device 1 ensures a high level of user comfort, in particular for people with motor impairments.
  • a good tactile perception of the holding device 1 can be achieved by a suitable choice of material and/or surface design of the holding device 1 embodied as a multi-holder, which further increases user comfort and simplifies precise positioning relative to the patient.
  • the design/configuration and determination of the external appearance of the holding device 1 can be made to meet high demands on the design of the holding device 1.
  • each dispensing device 2 can be configured for a single injection of a therapeutically and/or diagnostically effective substance.
  • the holding device 1 is embodied for the simultaneous substance dispensing via the dispensing devices 2 held on the holding device 1 , which in the embodiment shown takes place synchronously, i.e. simultaneously and at the same speed.
  • the design/construction of the holding device 1 in the state of holding multiple dispensing devices 2, enables simultaneous substance dispensing via the dispensing devices 2 on the same application plane 4 of the dispensing devices 2. This is shown schematically in Fig. 8.
  • the distal end of the actuators 3 and/or of the needle protection sleeves protrudes distally over the needle tips of the needles of the dispensing devices 2, so that access to the needle tips is initially prevented.
  • the actuators 3 By moving the actuators 3 by the actuating stroke in the proximal direction, the actuators 3 are moved until the needle protrudes from the distal end of the respective actuator 3, which protrusion may correspond to the injection depth of the needle into a puncture site of the patient.
  • the substance discharge I substance dispensing is triggered when the actuators 3 are pressed with distal end faces 6 against a dose delivery site.
  • the distal end faces 6 of the dispensing devices 2 lie in the same application plane 4. This ensures that when the dispensing devices 2 are held with the holding device 1 , both actuators 3 are simultaneously displaced in the proximal direction when the distal end faces 6 of the actuators 3 come into contact with the skin of a patient and are moved in the proximal direction when the holding device 1 is moved further in the distal direction and/or in the direction towards the patient and trigger the substance discharge I substance dispensing by a trigger mechanism inside the respective dispensing device 2.
  • the dispensing devices 2 are preferably held stationary on the holding device 1 . This means that there is no relative movement between the housing 5 of the dispensing devices 2 and the holding device 1 during substance dispensing. However, a relative movement of the actuators 3 relative to the holding device 1 is possible in order to trigger the substance discharge as described above.
  • the holding device 1 can also be embodied to hold different dispensing devices 2 for substance dispensing, which differ from one another, for example, by a different discharge volume of a therapeutically and/or diagnostically effective substance, a different geometry and/or external shape and/or by storing different therapeutically and/or diagnostically effective substances.
  • the holding device 1 is preferably of multi-piece construction and/or comprises several parts/components.
  • the holding device 1 has a holder housing 7 which is embodied for holding and, as shown in Fig. 1 , in particular for at least partially enclosing a plurality of dispensing devices 2.
  • the holder housing 7 is embodied to receive and enclose at least a major part or majority of the respective held dispensing device 2 inside the holder housing 7.
  • the holder housing 7 is designed or suitable for manually gripping the holding device 1 .
  • major part refers to a larger proportion of the volume and/or surface area of the dispensing devices 2 housed in the holding device 1.
  • a “major part” or “majority” in the sense of the invention is to be understood in particular as a larger proportion of the surface area of the housing 5 of the respective dispensing device 2 and/or a larger proportion of the volume of the respective dispensing device 2.
  • the majority of the respective dispensing device 2 is essentially received within the holder housing 7, so that the holder housing 7 determines the external appearance of the holding device 1 and only a very small part of the dispensing devices 2 contribute to the external appearance of the holding device 1.
  • Each dispensing device 2 may have an outer housing 5 and the holder housing 7 may be embodied to at least partially receive the outer housing 5, in particular to receive a major part I majority of the outer housing 5.
  • the holder housing 7 may have passages 8, wherein, in the state of holding multiple dispensing devices 2 on the holding device 1 , the actuators 3 and parts of the housings 5 of the dispensing devices 2 are guided outwards through the passages 8, protrude relative to the holder housing 7 and are thus perceptible from the outside.
  • the dispensing devices 2 can be completely encapsulated in the holder housing 7, with the exception of the actuators 3 and, if applicable, small surface areas of the housing 5 of the dispensing devices 2.
  • each dispensing device 2 has its own actuator 3 for triggering the substance discharge I substance dispensing and/or for triggering a mechanism that causes the substance dispensing.
  • a connecting element can also be provided that connects multiple actuators 3 to one another in order to effect simultaneous substance dispensing via multiple dispensing devices 2 by actuating the connecting element and thus triggering the actuators 3.
  • the holder housing 7 can comprise and/or form chambers 11 , 12 for at least partially spatially spaced apart and/or separate accommodation/receiving of multiple dispensing devices 2.
  • a double chamber can be provided for at least partially spatially spaced apart accommodation/receiving of two dispensing devices 2, in particular for accommodating/receiving two spatially separated autoinjectors with elongated housing 5.
  • the chambers 11 , 12 can be separated from each other at least section-wise by internal wall portions of the holder housing 7.
  • the chambers 11 , 12 can have the same chamber volume and/or be of the same design/shape, which is advantageous when using dispensing devices 2 of the same design/shape and/or dispensing devices 2 that have a housing 5 of the same design/shape.
  • Fixing elements can be provided on the holding device 1 and/or the holder housing 7 for fixing the dispensing devices 2 to the holding device 1 .
  • the holder housing 7 or the housing 5 of the dispensing device 2 can have fixing elements for forming a mechanical connection between the respective dispensing device 2 and the holding device 1 , in particular for forming a form-fit and/or force-fit connection.
  • Fixing elements can be provided on the holder housing 7, for example formed by wall portions of the holder housing 7, in particular by ribs or projections on inner surfaces of the holder housing 7, in order to prevent a linear movement of the dispensing devices 2 relative to the holder housing 7 in the longitudinal direction and/or in the transverse direction and/or a rotational movement of the dispensing devices 2 relative to the holding device 1 , when the dispensing devices 2 are fixed and/or held on the holding device 1.
  • Corresponding fixing elements can be provided on the holding device 1 and on the respective dispensing device 2, which form a mechanical connection in the holding state of the dispensing devices 2 and lead to the fixing of the dispensing devices 2 on and/or in the holding device 1.
  • the dispensing devices 2 can also be connected to the holding device 1 with a material bond, for example by welding or gluing.
  • the holder housing 7 is formed by a shell assembly with multiple shell parts connected to one another.
  • the shell assembly can have half-shell parts 9, 10 connected to one another in a housing center plane Y (Fig. 3) in an assembled state of the holding device 1.
  • chambers 11 , 12 for receiving/accommodating at least a predominant part of the dispensing devices 2 may be formed/provided between the half-shell parts 9, 10, which chambers are separated from one another partially or completely.
  • the chambers 11 , 12 can be essentially cylindrical and/or conical in the assembled state of the holding device 1 when the half-shell parts 9, 10 are placed one on top of the other and connected to each other.
  • ribs 13 can be formed/provided in the region of the central longitudinal axis X (Fig. 2) of the half-shell parts 9, 10 with the same or varying thickness in order to separate the chambers 11 , 12 from one another at least partially, preferably essentially completely, so that in the assembled state of the holding device 1 the dispensing devices 2 are held separately from one another inside the holding device 1 and/or between the half-shell parts 9, 10 and, preferably, in a fixed position.
  • Wall portions of the half-shell parts 9, 10 can enter into functional, mechanical interaction in the assembled state of the holding device 1 and thereby form a form-fit and/or force-fit connection between the half-shell parts 9, 10.
  • Wall portions of the half-shell parts 9, 10 can be embodied/shaped to complement each other for this purpose.
  • Fixing elements may be provided and/or formed on at least one half-shell part 9, 10, preferably on both half-shell parts 9, 10, which may interact with complementary fixing elements on the housing 5 of the respective dispensing device 2, in order to connect the half-shell parts 9, 10 to one another.
  • Each half-shell part 9, 10 has multiple, in particular two, separated entry openings 14 for the dispensing devices 2, wherein each half-shell part 9, 10 can be embodied in such a way that at least a major part of a dispensing device 2 inserted through a respective entry opening 14 is accommodated in the half-shell part 9, 10.
  • the half-shell parts 9, 10 can be connected to one another with the entry openings 14 facing one another.
  • the dispensing devices 2 are then arranged at least partially, preferably with a major part, between the half-shell parts 9, 10 in the state of holding with the holding device 1 .
  • the half-shell parts 9, 10 placed one on top of the other, the half-shell parts 9, 10 form, as explained above, a plurality of chambers 11 , 12 for preferably spatially spaced-apart accommodation of a plurality of dispensing devices 2, wherein the entry openings 14 are closed by the half-shell parts 9, 10 placed one on top of the other.
  • the half-shell parts 9, 10 can each preferably have semicircular opening geometries 15, 16 for the dispensing devices 2 at the distal face side end, wherein complementary opening geometries 15, 16 can form passages 8 for the outwardly guided regions of the dispensing devices 2 in the assembled state of the holding device 1.
  • the holder housing 7 is formed by and/or comprises two half-shell parts 9, 10 connected to one another indirectly or directly, in particular via a clamping connection and/or latching connection.
  • two grip shell parts 17, 18 are additionally provided, which can be U-shaped in crosssection.
  • the grip shell parts 17, 18 may have a curved inner side which is adapted to the shape of the connected half-shell parts 9, 10, in particular in order to be brought into a releasable or non-releasable clamping engagement with the connected halfshell parts 9, 10.
  • the grip shell parts 17, 18 may hold the half-shell parts 9, 10 together in the assembled state of the holding device 1 in a form-fit and/or force-fit manner, in particular in a latching and/or clamping manner, and, preferably, embrace/encompass the halfshell parts 9, 10 at least in some regions I partially on both sides from the outside. This results from a comparison of Figs. 1 and 2 to 4.
  • the grip shell parts 17, 18 can embrace the halfshell parts 9, 10 in the assembled state of the holding device 1 on opposite longitudinal sides 19, 20 of the half-shell parts 9, 10 from the outside and, in particular, hold them together by latching and/or clamping in a form-fitting and/or force-fitting manner.
  • openings 21 and projections 22 can be provided on the half-shell parts 9, 10 on the one hand and/or on the grip-shell parts 17, 18 on the other hand, which are complementary to each other, so that the grip-shell parts 17, 18 form positive I form-fit connections, in particular latching connections, with the half-shell parts 9, 10 when the grip-shell parts 17, 18 are pushed laterally onto the half-shell parts 9, 10, which are already connected to each other and enclose the dispensing devices 2.
  • the grip shell parts 17, 18 can be connected to the half-shell parts 9, 10 so that they cannot be detached without destruction or so that they can be detached without destruction.
  • the shape of the grip shell parts 17, 18 can be adapted to the shape of the half-shell parts 9, 10 placed on top of each other in the assembled state of the holding device 1.
  • projections in the embodiment shown in the form of beads 23, 24, can be provided in order to form a seat extending at least in some regions laterally over the two connected half-shell parts 9, 10, to which a respective grip shell part 17, 18 is attachable/fixable.
  • a substantially flush transition can be formed in the region of the seat edge between outer surfaces 25 of the grip shell parts 17, 18 and adjacent outer surfaces 26, 27 of the half-shell parts 9, 10.
  • the grip shell parts 17, 18 may have an outer profiling in the form of ribs 28 and/or a rubber covering in order to achieve improved tactile perception during handling of the holding device 1 and a high level of user comfort when holding the holding device 1 , in particular during substance dispensing.
  • the grip shell parts 17, 18 may be arranged adjacent to the proximal end of the holding device 1 and then extend from the middle region of the holding device 1 towards the proximal end of the holding device 1.
  • the grip shell parts 17, 18 may extend in the proximal direction to an edge strip 29 of the half-shell parts 9, 10 and thus be spaced from the proximal end of the holding device 1 .
  • the edge strip 29 may have a width of, for example, 0.5 cm to 2 cm.
  • the end in the proximal direction is formed by a housing cover 31 , which has a circumferential projection 32.
  • the housing cover 31 is attached to an outer edge 30 of the axial end of the holder housing 7.
  • the housing cover 31 can be fastened in a form-fitting and/or force-fitting manner or, as the case may be, also in a material-fitting manner by (adhesive) bonding or welding to the holder housing 7, in particular the half-shell parts 9, 10, which are placed on top of one another and connected in the assembled state, wherein the projection 32 can engage in a recess formed between the half-shell parts 9, 10, forming a clamping connection.
  • the holder housing 7 can have a profile shape of the outer surface with profile narrowings I profile constrictions 33, 34 and a central profile widening 36.
  • the profile constrictions 33, 34 are formed by concave surfaces of the holder housing 7.
  • the profile constrictions 33, 34 can be formed to run around in the circumferential direction and/or extend over both wider flat sides or the top side and the bottom side (Fig. 3) and both narrower flat sides or the left and right outer sides (Fig. 2) of the holder housing 7.
  • the holder housing 7 thus preferably has a substantially concave surface shape and/or the surface of the grip shell parts 17, 18 is substantially curved inwards.
  • a first profile narrowing / first profile constriction 33 may be formed/provided adjacent to the distal end of the holder housing 7.
  • a second profile narrowing I second profile constriction 34 may be formed/provided adjacent to the proximal end of the holder housing 7.
  • the first profile constriction 33 can extend between an edge strip 35 at the distal end of the holder housing 7 and a central region, in particular the central profile widening 36, of the holder housing 7.
  • the edge strip 35 may have axis-parallel outer surfaces, in particular parallel to the center longitudinal axis X.
  • the edge strip 35 and the central region can each define a widening of the housing profile.
  • the second profile constriction 34 can extend from the central region, in particular the central profile widening 36, in the proximal direction up to the edge strip 29 of the holder housing 7, wherein the edge strip 29 can have axis-parallel outer surfaces, in particular parallel to the center longitudinal axis X.
  • the edge strip 29 forms a further profile widening.
  • profile constriction and “profile widening” refer in particular to the profile of the holder housing 7 in a view of the holding device 1 from above (Fig. 2) and/or in a side view (Fig. 3). Due to the central profile widening 36, the further profile widenings at the ends of the holder housing 7 and the profile constrictions 33, 34 in between, the holder housing 7 can have an undulating profile. This follows from Figs. 2 and 3, wherein dash lines 37, 38 make the profile of the holder housing 7 apparent. The dash lines 37, 38 are placed tangentially to the proximal edge portion I edge strip 29 and the distal edge portion I edge strip 35 of the holder housing 7.
  • the half-shell parts 9, 10 may have viewing windows 39 adjacent to the distal end of the holding device 1 , in particular wherein the viewing windows 39 in the assembled state of the holding device 1 may be arranged opposite viewing windows 58 of the dispensing devices 2 (cf. Fig. 9). Preferably, opposite viewing windows 39 are provided for each dispensing device 2.
  • the viewing windows 39 it is possible, for example, to visually observe the substance dispensing after triggering an automatic substance dispensing when using two autoinjectors.
  • Each dispensing device 2 may, for example, contain a product container in the shape of a syringe, which is accommodated immovably in a longitudinal axis of the dispensing device 2.
  • the product container can have a sleeve-shaped syringe body I syringe barrel, which surrounds a plunger or piston that fits tightly against the inner circumference of the syringe body.
  • the syringe body can have an injection needle at its distal end, wherein a liquid substance, for example a medication/medicine, can be arranged within the syringe body between the injection needle and the plunger or piston.
  • the substance can be dispensed/discharged from the product container through the injection needle by moving the plunger or piston in a distal dispens- ing/discharge direction towards the injection needle.
  • the displacement movement of the plunger or piston in the distal discharge direction I dispensing direction, and thus the progress of the discharge process, can be visually inspected through the viewing window 39 after the trigger mechanism for a drive of the plunger or piston has been triggered.
  • the holder housing 7 can have a contour at its distal end in the circumferential direction that is adapted to the cylindrical housing shape of the dispensing devices 2 and/or the circular passages 8 of the holder housing 7.
  • the contour can have outer convex contour portions 46, which are arranged adjacent to both longitudinal sides 19, 20 on both sides of the central longitudinal axis X (Fig. 2) and are connected to one another by central concave contour portions 47 in the region of the central longitudinal axis X.
  • a pull-off cap 40 may be provided at the distal, front end of the arrangement, which is pulled off or, as the case may be, twisted off and removed before the dispensing devices 2 are used.
  • a pull-off cap for pulling off a needle protection cap is described, for example, in EP 2745866 A1 . This known pull-off cap is embodied and functionalized for use with only one dispensing device.
  • the housings 5 of the dispensing devices 2 can pass through the passages 8 of the holding device 1 at their distal ends in the holding state of the dispensing devices 2, so that an edge strip 41 of each housing 5 projects/protrudes distally with respect to a distal end face 42 (Fig. 4) of the holding device 1.
  • the pull- off cap 40 can be connected to the dispensing devices 2 in the region of the edge strips 41 of the housings 5, in particular plugged onto the edge strips 41.
  • the actuators 3 of the dispensing devices 2 extend through the passages 8 and project/protrude distally with respect to the distal end face 42 of the holder housing 7.
  • the pull-off cap 40 can form two separate receiving regions 48, 49 for the actuators 3 (Fig. 6).
  • the pull-off cap 40 can have stiffening ribs on the inner wall.
  • the actuators 3 may be needle protection sleeves which are displaceable relative to the housing 5 and along the longitudinal axis of the housing 5 of the respective dispensing devices 2 by an actuating stroke in a proximal direction into an actuated position in order to trigger a substance discharge I substance dispensing.
  • the distal end of the needle protection sleeve projects/protrudes distally over a needle tip of a syringe barrel I syringe body contained in the housing 5 of the respective dispensing device 2. This initially prevents access to the needle tip.
  • the needle protection sleeve By displacing the needle protection sleeve by an actuating stroke in the proximal direction, the needle protection sleeve is displaced until the needle protrudes from the distal end of the needle protection sleeve, which corresponds to the injection depth of the needle into a puncture site of a patient.
  • the trigger mechanism of the dispensing devices 2 can correspond to the trigger mechanism of the autoinjectors known from EP 2 742 962 A2.
  • the pull-off cap 40 can be pushed, slid and/or plugged onto the edge portions I edge strips 41 with a wall portion 43 extending in the axial direction.
  • the contour of the pull-off cap 40 at the proximal edge of the wall portion 43 can follow, in the circumferential direction of the pull-off cap 40, the contour of the two edge strips 41 of the housings 5 of the dispensing devices 2.
  • the two dispensing devices 2 are arranged laterally to the central longitudinal axis X next to each other.
  • a needle of the respective dispensing device 2 may be covered by a needle protection cap or a rigid needle shield I soft needle shield to protect the needle from contamination and to keep a substance inside the syringe body sterile.
  • the needle protection cap can be arranged on a needle holding portion of the syringe body.
  • the pull-off cap 40 can, in particular, be connected to the dispensing devices 2 and/or to the holder housing 7 in a form-fit I positive and/or force-fit I non-positive manner, for example via a snap-on connection.
  • the pull-off cap 40 can be detachably connected, in particular snapped, to the dispensing devices 2 in the region of the edge strips 41 of the housing 5 or to needle protection sleeves of the dispensing devices 2, which form the actuators 3 for triggering the substance dispensing. This snapping can be released when the pull-off cap 40 is removed from the housings 5 and/or the needle protection sleeves.
  • the pull-off cap 40 By connecting the pull-off cap 40 to both dispensing devices 2 in the initial or as-delivered state of the holding device 1 , secure retention/holding of the pull-off cap 40 on the holding device 1 via the dispensing devices 2 is ensured.
  • the pull-off cap 40 could also be connected directly to the holder housing 7 of the holding device 1 in a form-fit and/or force-fit detachable manner.
  • a needle of the respective dispensing device 2 may be covered by a needle protection cap, which may be embodied as a so-called rigid needle shield or soft needle shield, in order to protect the needle from contamination and to keep the substance inside the product container sterile.
  • the needle protection cap can be arranged on a needle holding portion of a syringe body I syringe barrel of the respective dispensing device 2.
  • the pull-off cap 40 can comprise two pull-off members 44, which can be embodied as catches, each catch engaging in a gap between the syringe body of a dispensing device 2, in particular its tapering region, and a proximal end of the needle protection cap of the respective dispensing device 2.
  • the pull-off cap 40 When the pull-off cap 40 is removed from the holding device 1 , the catch can hook into the gap, whereby the needle protection cap of the respective dispensing device 2 can be released from the syringe body and removed from the dispensing device 2 together with the pull-off cap 40.
  • the pull-off cap 40 enables the simultaneous pulling off and/or removal of needle protection caps of the dispensing devices 2.
  • the pull-off members 44 engage in proximal direction in the actuators 3 embodied as needle protection sleeves.
  • the pull-off cap 40 accommodates/receives the actuators 3 of the dispensing devices 2 at least partially, preferably completely.
  • the actuators 3 and, preferably, the edge strips 41 of the housings 5 of the dispensing devices 2, which pass through the passages 8 of the holder housing 7 and project distally with respect to the distal end face 42 of the holder housing 7, are preferably completely encased/enclosed by the pull-off cap 40.
  • the actuators 3 and the edge strips 41 of the housings 5 of the dispensing devices 2, which project distally through the passages 8 of the holder housing 7, are then surrounded fully and/or surrounded in the circumferential direction of the pull-off cap 40 over the entire circumference by the edge portion I wall portion 43 of the pull-off cap 40.
  • the pull-off members 44 can be an integral part of the pull-off cap 40 and/or consist of a plastic material and/or be molded onto the pull-off cap 40.
  • the pull-off cap 40 can be transparent and/or made of a transparent plastic material.
  • the pull-off members 44 can be integrally molded on a wall portion 45 of the pull-off cap 40, which forms a distal end of the pull-off cap 40.
  • the pull-off members 44 can each have one or more snap-on arms for forming a snap-on connection with a needle protection cap of the respective dispensing device 2.
  • the pull-off members 44 can have pull-off sleeves, for example made of metal, wherein each pull-off sleeve can have at least one snap-on projection, which is provided for pulling off a needle protection cap of the respective dispensing device 2.
  • the pull-off sleeves can be connected to the pull- off cap 40 in a form-fit and/or force-fit manner.
  • sleeve-shaped holding portions can be molded and/or formed/provided on the inside of the pull-off cap 40, into which the pull-off sleeves are insertable and, if applicable, connectable to the pull-off cap 40 via a snap connection.
  • the holding device 1 can be adapted and/or individualized for the use of dispensing devices 2 with a specific shape, i.e. with specific external geometries and/or specific dimensions. Individualization can be provided in such a way that it is only possible to hold certain dispensing devices 2 on the holding device 1 according to the invention.
  • the holding device 1 according to the invention can preferably be provided and/or embodied only for holding such dispensing devices 2 which have a specific substance dispensing volume and/or a therapeutically and/or diagnostically effective substance of a specific type and/or composition.
  • the holding device 1 according to the invention can comprise distinguishing means (not shown) in order to indicate that the holding device 1 can only be used for holding certain dispensing devices 2 and/or to ensure that only certain dispensing devices 2 are used.
  • the holding device 1 can, for example, only be embodied to hold dispensing devices 2 with certain geometric features, in particular with a certain size and/or shape of the housing 5 of the dispensing devices 2. Geometric features of the dispensing devices 2 then represent distinguishing means within the sense of the invention.
  • the holding device 1 may have receiving regions, such as chambers 11 , 12, for the dispensing devices 2 to be held. Only those dispensing devices 2 can then be connected to the holding device 1 according to the invention whose size and/or shape, in particular of the outer housing 5 of the dispensing devices 2, corresponds to the size and/or shape of the receiving regions.
  • the holding device 1 can be constructed to hold two autoinjectors with different discharge volumes, wherein a first autoinjector can have a maximum discharge volume of 2.5 ml and a second autoinjector can have a maximum discharge volume of 5 ml, for example.
  • the holding device 1 can then have two chambers of different sizes, wherein a first chamber can be formed to hold the first autoinjector and a second chamber can be formed to hold the second autoinjector with larger discharge volume.
  • Mechanically effective elements such as projections and/or recesses, can also be provided on the dispensing devices 2, which interact with corresponding mechanical elements, such as recesses and/or projections, on the holding device 1 when the dispensing devices 2 are or have been inserted into the receiving regions of the holding device 1 , for example the chambers 11 , 12. Dispensing devices 2 that do not have such corresponding effective elements cannot then be used together with the holding device 1 according to the invention.
  • the mechanically effective elements then also represent distinguishing means within the sense of the invention.
  • certain regions of the holding device 1 and of a certain dispensing device 2 can also have the same coloring as distinguishing means and/or the holding device 1 and the dispensing device 2 can have a same coding, for example in the form of numbers or letters. Electronic coding is also possible. The coloring and/or the coding can then be used to ensure that the holding device 1 is only used with intended dispensing devices 2.
  • the holding device 1 according to the invention is intended to be used, in particular simultaneously, with a plurality of different dispensing devices 2, which may in particular contain different discharge volumes and/or different substances, distinguishing means of the type described above may also be provided in order to indicate to a user an intended position of the respective dispensing device 2 on and/or in the holding device 1.
  • the holding device 1 shown is constructively and functionally only for holding dispensing devices 2 that are identical, in particular with regard to the discharge volume and/or further in particular with regard to the trigger mechanism.
  • the holding device 1 can also be embodied to hold different dispensing devices.
  • the holding device 1 is preferably embodied for a stationary holding of the dispensing devices 2 during substance dispensing. In particular, there is then no relative movement of the housings 5 of the dispensing devices 2 relative to the holding device
  • the actuators 3 can perform a relative movement for triggering the trigger mechanism of the dispensing devices 2.
  • Figs. 9 to 13 show a further embodiment of an arrangement according to the invention comprising a holding device 1 for two dispensing devices 2, for example autoinjectors, further for example autoinjectors of the type described in EP 2 742 962 A2.
  • Identical components and identical structural and/or functional designs/configura- tions of the arrangement shown in Figs. 5 to 8 and the arrangement shown in Figs. 9 to 13 are indicated by identical reference signs.
  • the holding device 1 is again embodied for holding two dispensing devices 2 and for substance dispensing via both dispensing devices 2 held on the holding device 1.
  • the dispensing devices 2 are arranged in a stationary manner and/or fixed on the holding device 1 , so that in the holding state a substance dispensing is possible via at least one dispensing device 2, in the embodiment shown simultaneously via both dispensing devices
  • the construction of the holding device 1 allows a substance dispensing via both dispensing devices 2 without having to separate them from the holding device 1.
  • the holding device 1 then in turn serves/functions as an application aid when dispensing substance to a patient via the dispensing device 2.
  • the axial end faces 50 of the housings 5 of the dispensing devices 2 are preferably flush in the distal direction with axial end faces 51 of the half-shell parts 9, 10 in the state of holding the dispensing devices 2.
  • the housings 5 of the dispensing devices 2 can also be guided outwards in the axial direction through the passages, so that the housings 5 protrude with an axial edge strip relative to the holder housing 7 and are also perceivable from the outside.
  • the holder housing 7 or the housing of the dispensing device 2 can have fixing elements for forming a mechanical connection between the respective dispensing device 2 and the holding device 1 , in particular for forming a form-fit and/or force-fit connection.
  • fixing elements 52, 53 can be formed/provided on the inner sides of the half-shell parts 9, 10, for example formed by, in particular rib-shaped, wall portions on the inner surfaces of the half-shell parts 9, 10, which can preferably interact with a corresponding complementary geometry and/or complementarily formed surface portions on the outer side of the housings 5 of the dispensing devices 2.
  • a linear movement of the dispensing devices 2 relative to the holder housing 7 in the longitudinal direction and/or in the transverse direction and/or a rotational movement of the dispensing device 2 relative to the holding device 1 can be prevented when the dispensing devices 2 are fixed and/or held on the holding device 1.
  • complementary fixing elements can be provided on the holding device 1 and on the respective dispensing device 2, which form a mechanical connection in the holding state of the dispensing devices 2 and lead to the fixing of the dispensing device 2 on and/or in the holding device 1 .
  • latching lugs 54, 55 can be provided on the upper half-shell part 9, which engage in corresponding latching recesses 56, 57 in the lower half-shell part 10 when the half-shell parts 9, 10 are connected to one another in the assembled state of the holding device 1.
  • the latching lugs 54, 55 can snap resiliently into the latching recesses 56, 57.
  • connection between the half-shell parts 9, 10 can, moreover, be provided by a tongue and groove form fit via the edges of the half-shell parts 9, 10.
  • grip shell parts 17, 18 which can be brought into a releasable or non-releasable clamping engagement with the connected half-shell parts 9, 10.
  • the grip shell parts 17, 18 can hold the half-shell parts 9, 10 together in a form-fitting and/or force-fitting manner in the assembled state of the holding device 1 and embrace the half-shell parts 9, 10 from the outside at least in certain regions on both sides.
  • the connection of the grip shell parts 17, 18 to the half-shell parts 9, 10 is preferably made in the present case via at least two projections 22 on each grip shell part 17, 18 and complementary openings 21 in the respective half-shell part 9, 10.
  • a pull-off cap 40 may be provided at the distal end of the arrangement. According to Fig. 9 and Fig. 10, the pull-off cap 40 can be held on the actuators 3 of the dispensing devices 2, in particular can be plugged onto the actuators 3.
  • the half-shell parts 9, 10 can comprise on the inside at the proximal end a preferably circumferential web-shaped holding and/or reinforcing portion 59 extending inwards in the radial direction, which can also lead to an axial fixing of the dispensing device 2 in the half-shell parts 9, 10.
  • At least one half-shell part 9, 10 can have a label carrier 60 which is embodied to display information to a user about the type and/or quantity and/or composition of the therapeutically and/or diagnostically effective substance to be dispensed with the dispensing devices 2.
  • the label carrier 60 can be embodied as a separate element that can be connected to a half-shell part 9, 10 in a form-fitting and/or force-fitting manner, in particular in a latching and/or clamping manner. In the simplest case, however, the label carrier 60 can also be a tag/sticker that is affixed to the outer surface of the half-shell part 9, 10.
  • the configuration/design of the label carrier 60 as a separate labeling element, which is detachably connected to the half-shell part 9, 10, offers the advantage that the holding device 1 can be used in a simple manner for dispensing devices 2 which differ in the type and/or quantity and/or composition of the substance to be dispensed, wherein different information can be applied to the label carrier 60 for labeling different substance types, substance quantities and/or substance compositions.
  • the holding device 1 is preferably disposable and/or embodied for single use only. As already mentioned, the arrangement formed by the holding device 1 and the plurality of dispensing devices 2 - once assembled - cannot be separated/dissembled in a non-destructive manner. Preferably, the holding device 1 , in particular the halfshell parts 9, 10 of the holder housing 7 - once connected to one another by means of the grip shell parts 17, 18 -, cannot be opened/separated in a non destructive manner.
  • the holding device 1 it is possible to separate/open the holding device 1 , in particular the half-shell parts 9, 10, without destruction, e.g., by removing the grip shell parts 17, 18 from the half-shell parts 9, 19. In this way, the holding device 1 can be reused.

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  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif de maintien (1) pour un dispositif de distribution (2), en particulier pour un auto-injecteur, pour la distribution d'une substance efficace sur le plan thérapeutique et/ou diagnostique. Selon l'invention, le dispositif de maintien (1) est conçu sous la forme d'un support multiple pour maintenir au moins deux dispositifs de distribution (2) sur le dispositif de maintien (1) et, dans l'état de maintien des dispositifs de distribution (2), pour une distribution de substance par l'intermédiaire d'au moins un dispositif de distribution (2) maintenu sur le dispositif de maintien (1).
PCT/EP2024/065687 2023-06-12 2024-06-07 Dispositif de maintien pour dispositifs de distribution pour la distribution de substances d'au moins une substance efficace sur le plan thérapeutique et/ou diagnostique Pending WO2024256275A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP23178581 2023-06-12
EP23178581.7 2023-06-12

Publications (1)

Publication Number Publication Date
WO2024256275A1 true WO2024256275A1 (fr) 2024-12-19

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PCT/EP2024/065687 Pending WO2024256275A1 (fr) 2023-06-12 2024-06-07 Dispositif de maintien pour dispositifs de distribution pour la distribution de substances d'au moins une substance efficace sur le plan thérapeutique et/ou diagnostique

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Country Link
WO (1) WO2024256275A1 (fr)

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014006B1 (fr) 1979-01-25 1983-09-21 Survival Technology, Inc. Dispositif d'injection multiple actionné par ressorts
US20050203464A1 (en) 2002-01-11 2005-09-15 Timothy Haider Apparatus and methods for simultaneously administering two or more medications to a patient
EP1494740B1 (fr) 2002-04-16 2009-12-30 Pfizer Health AB Systeme de modification d'un dispositif et dispositif approprie a cette modification
WO2011124633A1 (fr) 2010-04-09 2011-10-13 Sanofi-Aventis Deutschland Gmbh Procédé et système de différenciation de dispositifs d'administration de médicament
EP2688604A1 (fr) 2011-03-22 2014-01-29 Pfizer Health AB Capuchon destiné à recevoir une seringue, ensemble comprenant un tel capuchon, stylo-injecteur comprenant un tel ensemble et procédé de formation d'un stylo-injecteur
EP2742962A2 (fr) 2013-03-22 2014-06-18 TecPharma Licensing AG Auto-injecteur doté d'un dispositif de signalisation à la fin de la distribution de produit
EP2745866A1 (fr) 2014-01-30 2014-06-25 TecPharma Licensing AG Sécurité de déclenchement pour un injecteur de voiture
US20160158450A1 (en) * 2011-01-24 2016-06-09 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
CH711066A2 (de) 2015-05-13 2016-11-15 Tecpharma Licensing Ag Verbesserte Injektionsvorrichtung.
WO2018078121A1 (fr) 2016-10-27 2018-05-03 Pharma Consult Ges.M.B.H. Dispositif d'injection, en particulier autoinjecteur, pour l'administration simultanée de plusieurs médicaments
EP3213784B1 (fr) 2013-11-28 2020-08-19 SHL Medical AG Dispositif pour un dispositif d'administration de médicaments

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014006B1 (fr) 1979-01-25 1983-09-21 Survival Technology, Inc. Dispositif d'injection multiple actionné par ressorts
US20050203464A1 (en) 2002-01-11 2005-09-15 Timothy Haider Apparatus and methods for simultaneously administering two or more medications to a patient
EP1494740B1 (fr) 2002-04-16 2009-12-30 Pfizer Health AB Systeme de modification d'un dispositif et dispositif approprie a cette modification
WO2011124633A1 (fr) 2010-04-09 2011-10-13 Sanofi-Aventis Deutschland Gmbh Procédé et système de différenciation de dispositifs d'administration de médicament
US20160158450A1 (en) * 2011-01-24 2016-06-09 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
EP2688604A1 (fr) 2011-03-22 2014-01-29 Pfizer Health AB Capuchon destiné à recevoir une seringue, ensemble comprenant un tel capuchon, stylo-injecteur comprenant un tel ensemble et procédé de formation d'un stylo-injecteur
EP2742962A2 (fr) 2013-03-22 2014-06-18 TecPharma Licensing AG Auto-injecteur doté d'un dispositif de signalisation à la fin de la distribution de produit
EP3213784B1 (fr) 2013-11-28 2020-08-19 SHL Medical AG Dispositif pour un dispositif d'administration de médicaments
EP2745866A1 (fr) 2014-01-30 2014-06-25 TecPharma Licensing AG Sécurité de déclenchement pour un injecteur de voiture
CH711066A2 (de) 2015-05-13 2016-11-15 Tecpharma Licensing Ag Verbesserte Injektionsvorrichtung.
WO2018078121A1 (fr) 2016-10-27 2018-05-03 Pharma Consult Ges.M.B.H. Dispositif d'injection, en particulier autoinjecteur, pour l'administration simultanée de plusieurs médicaments

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