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WO2024255796A1 - Dispositif de biopsie à échantillonnage multiple, procédé d'échantillonnage multiple et appareil d'échantillonnage - Google Patents

Dispositif de biopsie à échantillonnage multiple, procédé d'échantillonnage multiple et appareil d'échantillonnage Download PDF

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Publication number
WO2024255796A1
WO2024255796A1 PCT/CN2024/098988 CN2024098988W WO2024255796A1 WO 2024255796 A1 WO2024255796 A1 WO 2024255796A1 CN 2024098988 W CN2024098988 W CN 2024098988W WO 2024255796 A1 WO2024255796 A1 WO 2024255796A1
Authority
WO
WIPO (PCT)
Prior art keywords
telescopic
cup
sampling
telescopic member
distal end
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/CN2024/098988
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English (en)
Chinese (zh)
Inventor
程永华
吴家微
韩春琦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HANGZHOU AGS MEDTECH CO Ltd
Original Assignee
HANGZHOU AGS MEDTECH CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN202311109750.8A external-priority patent/CN117297672A/zh
Application filed by HANGZHOU AGS MEDTECH CO Ltd filed Critical HANGZHOU AGS MEDTECH CO Ltd
Publication of WO2024255796A1 publication Critical patent/WO2024255796A1/fr
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/04—Endoscopic instruments, e.g. catheter-type instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/06—Biopsy forceps, e.g. with cup-shaped jaws

Definitions

  • the present application relates to the technical field of medical devices, and in particular to a multi-sampling biopsy device, a multi-sampling method and a sampling apparatus.
  • biopsy forceps and similar medical devices can only complete one sampling with one insertion of the scope.
  • multiple sampling and acquisition of multiple tissues are often required. Therefore, when using traditional biopsy forceps for multiple sampling, the scope needs to be repeatedly withdrawn and inserted, which leads to many problems such as multiple single sampling, cumbersome operation, low surgical efficiency, long operation time, pain for patients, and susceptibility to infection by bacteria.
  • a multi-sampling biopsy device a multi-sampling method, and a sampling apparatus are provided.
  • the present application provides a multi-sampling biopsy device, which includes: a clamp body mechanism, including a clamp cup and a clamp seat that are movably connected, wherein a collection chamber and a storage chamber that are adjacent and through-connected are formed inside the clamp body mechanism, and the collection chamber is located on the far side of the storage chamber; a telescopic member, which is arranged in the clamp body mechanism, and the telescopic member is provided with a collection part and a storage part, and the collection part is located on the far side of the storage part, and the telescopic member can be driven to move back and forth in the collection chamber and the storage chamber, so that the collection part collects tissue and the storage part stores tissue; and a guide member, which is arranged on the outer periphery of the telescopic member, and is used to guide the telescopic member to move back and forth relative to the clamp body mechanism in the proximal and distal directions; when the telescopic member is displaced toward the distal side, the distal end of the
  • the present application provides a multi-sampling method, which adopts the aforementioned multi-sampling biopsy device, and the steps of the multi-sampling method include: S1: in the initial state, the distal end of the telescopic member is located in the forceps cup and close to the distal end of the forceps cup.
  • the forceps cup is driven to open, so that the collection part at the distal end of the telescopic member enters the tissue to be collected;
  • S2 the forceps cup is driven to close so that the forceps cup removes the tissue;
  • S3 the telescopic member is driven to move toward the distal side, so that the distal end of the telescopic member opens the forceps cup and the tissue removed by S2 is stopped in the forceps cup, and then the tissue stopped in the forceps cup is moved toward the proximal side of the telescopic member to the storage part, freeing up the collection part;
  • S4 the telescopic member is driven to move in the proximal direction so that the telescopic member returns to the initial state, and at the same time, the tissue at the storage part follows the telescopic member to move in the proximal direction, so that the tissue at the storage part leaves the collection chamber and enters the storage chamber; at this time
  • the present application provides a sampling device, which includes: an operating mechanism; and the aforementioned multi-sampling biopsy device, wherein the clamp body mechanism and the telescopic member are respectively driven by the operating mechanism.
  • the present application provides an operating mechanism, which includes a handle body and multiple control members; the multiple control members are movably connected to the handle body, and each control member is connected to a driving member, which is used to connect to a distal component; wherein each control member can reciprocate relative to the handle body in the distal and proximal directions, and each control member has a movement tendency to reset toward the distal side or toward the proximal side, and each control member can drive the corresponding driving member to move synchronously and thereby drive the distal component to move.
  • the present application provides a sampling method, which is based on the aforementioned sampling device and includes the following steps: S10: in the initial state, the distal end of the telescopic member is located in the forceps cup and close to the distal end of the forceps cup.
  • the first control member When the sampling device is located at the tissue to be collected, the first control member is driven to move toward the distal end, the forceps cup is driven to open, and the collection portion at the distal end of the telescopic member enters the tissue to be collected;
  • S20 under the movement trend of resetting, the first control member moves toward the proximal end, the forceps cup is driven to close, and the forceps cup removes the tissue;
  • S30 the second control member is driven to move toward the distal end, the telescopic member is driven to close, and the collection portion at the distal end of the telescopic member enters the tissue to be collected;
  • the distal end of the retracting member opens the forceps cup and the tissue removed in S20 is always stopped in the forceps cup, so that the tissue stopped in the forceps cup moves toward the proximal side of the telescopic member to the storage part, leaving the collection part empty;
  • S40 under the resetting movement trend, the second control member moves toward
  • FIG1 is a partial schematic diagram of a multi-sampling biopsy device according to one or more embodiments
  • FIG2 is a schematic diagram of the overall structure of the clamp cup in FIG1 ;
  • FIG3 is a schematic diagram of the overall structure of a telescopic member according to one or more embodiments.
  • FIG4 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments.
  • FIG5 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments
  • FIG6 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments.
  • FIG7 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments.
  • FIG8 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments.
  • FIG9 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments.
  • FIG10 is a first partial schematic diagram of a sampling device according to one or more embodiments.
  • FIG11 is a first partial cross-sectional view of an operating mechanism according to one or more embodiments.
  • FIG12 is a partial enlarged view of point A provided in FIG11;
  • FIG13 is a partial enlarged view of point B provided in FIG11;
  • FIG14 is a partial enlarged view of point C provided in FIG11;
  • 15 is a second partial cross-sectional view of an operating mechanism according to one or more embodiments.
  • 16 is a first partial cross-sectional view of a sampling device according to one or more embodiments.
  • FIG. 17 is a second schematic diagram of a clamp cup according to one or more embodiments.
  • FIG. 18 is a third schematic diagram of a clamp cup according to one or more embodiments.
  • 19 is a second schematic diagram of a telescopic member in a sampling device according to one or more embodiments.
  • 100 clamp body mechanism; 101, distal component; 110, clamp cup; 111, cup body; 1110, cup mouth; 1111, end edge; 1112, side edge; 1113, open mouth; 1114, storage chamber; 1115, drainage hole; 1116, fixing hole; 1117, hinge hole; 1118, guide groove; 112, connector; 113, pin shaft; 120, clamp seat; 121, tube seat; 122, connecting column; 130, collection chamber; 140, storage chamber; 141, A storage cavity portion sealed in the circumferential direction; 150, telescopic member; 1502, telescopic member distal end; 1503, telescopic member proximal end; 151, barb structure; 1511, anti-slip protrusion; 1512, anti-slip depression; 152, collection part; 1521, needle body; 153, storage part; 154, first stopper; 1550, release member; 155, second stopper; 1551, connecting tube; 156, small-diameter disconnection part; 160, guide member; 161, guide member distal
  • sheath tube mechanism 210, sheath tube; 211, telescopic drive member; 212, opening and closing drive member; 213, spring tube; 214, support tube; 215, lubrication tube; 300, tissue; 301, first tissue; 302, second tissue;
  • 400 operating mechanism; 410, handle body; 411, grip rod body; 412, connecting sleeve; 4121, connecting cavity; 413, grip ring; 4101, assembly cavity; 4102, guide slot; 4103, release space; 420, control member; 4201, first control member; 4202, second control member; 421, connecting hole; 422, bending section; 430, driving member; 4311, rod-shaped connecting member Connecting part; 4312, hooking section; 431, traction rope; 432, coupling piece; 433, main rope; 440, limiting seat; 441, first limiting seat; 442, second limiting seat; 450, elastic member; 451, first elastic member; 452, second elastic member; 4401, second through hole; 4402, positioning groove; 4403, positioning column; 1000, multi-sampling biopsy device; 2000, sampling equipment.
  • first and second are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as “first” and “second” may explicitly or implicitly include at least one of the features. In the description of this application, the meaning of "plurality” is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.
  • a first feature being “above” or “below” a second feature may mean that the first feature is directly in contact with the second feature, or the first feature and the second feature are indirectly in contact through an intermediate medium.
  • a first feature being “above”, “above” or “above” a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature.
  • a first feature being “below”, “below” or “below” a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.
  • Figures 4 to 8 are sectional views, and in order to more clearly show the movement of the telescopic member 150 and the tissue 300 in the forceps cup 110, a perspective effect is provided here, and Figures 1 to 3 are normal displays.
  • the collection cavity 130, the storage cavity 140, the collection part 152, and the storage part 153 are located at the positions of the corresponding parts in the dotted frame.
  • distal and proximal ends referred to in this application are based on the doctor, the end close to the doctor is the proximal end or the proximal part, and the end away from the doctor is the distal end or the distal part.
  • the side facing the doctor is the proximal side or the proximal side, and the side facing away from the doctor is the distal side or the distal side.
  • the distal direction and the proximal direction represent two directions; the proximal-distal direction is parallel to the distal direction and the proximal direction, and the proximal-distal direction does not specifically refer to the forward or reverse direction.
  • biopsy forceps and similar medical devices can only complete one sampling with one insertion of the scope.
  • multiple sampling and acquisition of multiple tissues are often required. Therefore, when using traditional biopsy forceps for multiple sampling, the scope needs to be repeatedly withdrawn and inserted, which leads to many problems such as multiple single sampling, cumbersome operation, low surgical efficiency, long operation time, pain for patients, and susceptibility to infection by bacteria.
  • the present application proposes a multi-sampling biopsy device and a multi-sampling method.
  • the present application includes the following advantages: multiple samplings can be completed with only one insertion of the mirror, without the need to repeatedly withdraw and insert the mirror. It has many advantages such as multiple samplings, simplified operation, high surgical efficiency, greatly shortened time, reduced patient pain, hygiene and safety, and high biopsy accuracy. In the process of multiple sampling, it also has the advantages of high sampling stability, accurate positioning, simple multi-sampling process, avoidance of misoperation, and smooth and no jamming.
  • the present application provides a multi-sampling biopsy device 1000 , which may include: a clamp body mechanism 100 , a telescopic member 150 , and a guide member 160 .
  • the clamp body mechanism 100 includes a clamp cup 110 and a clamp seat 120 that are movably connected.
  • a collection chamber 130 and a storage chamber 140 that are adjacent and connected are formed inside the clamp body mechanism 100.
  • the collection chamber 130 is located at the far side of the storage chamber 140.
  • the telescopic member 150 is disposed in the clamp body mechanism 100.
  • the telescopic member 150 is provided with a collection portion 152 and a storage portion 153, wherein the collection portion 152 is located far from the storage portion 153.
  • the telescopic member 150 can be driven to move back and forth in the collection cavity 130 and the storage cavity 140, so that the collection portion 152 collects the tissue 300 and the storage portion 153 stores the tissue 300.
  • the collecting portion 152 and the storage portion 153 may be disposed on the periphery of the telescopic member 150.
  • the telescopic member 150 includes a telescopic member distal end 1502 and a telescopic member proximal end 1503.
  • a portion of the collecting portion 152 may be disposed on the telescopic member distal end 1502.
  • the periphery of the telescopic member 150 may refer to the radial periphery of the telescopic member 150.
  • the space referred to by the periphery of the telescopic member 150 may be the same length as the telescopic member 150, or may extend to the proximal side and/or the distal side of the telescopic member 150.
  • the distal end and the proximal end of the forceps cup 110 may be referred to as the distal end 1 of the forceps cup and the proximal end 2 of the forceps cup; similarly, the distal end and the proximal end of the telescopic member 150 may be referred to as the telescopic member distal end 1502 and the telescopic member proximal end 1503.
  • the distal end of the forceps cup 110 may be referred to as the first distal end
  • the distal end of the telescopic member 150 may be referred to as the first distal end.
  • the second far end may be referred to as the first distal end 1 of the forceps cup and the proximal end 2 of the forceps cup.
  • the guide member 160 is disposed on the outer periphery of the telescopic member 150 to guide the telescopic member 150 to move back and forth relative to the clamp body mechanism 100 in the distal and proximal directions.
  • the guide member 160 may surround 360° along the circumference of the telescopic member 150, or surround a portion thereof; the guide member 160 may be discontinuous in multiple sections.
  • the multi-sampling biopsy device 1000 as a whole has a distal side and a proximal side.
  • the telescopic member distal end 1502 can protrude from the distal end 1 of the forceps cup to open the forceps cup 110, and the tissue 300 at the collection portion 152 is stopped in the forceps cup 110, so that the tissue 300 stopped in the forceps cup 110 is displaced toward the proximal end 1503 of the telescopic member to the storage portion 153.
  • the telescopic member 150 moves toward the distal side relative to the tissue 300; which is equivalent to causing the tissue 300 to displace toward the proximal side of the telescopic member 150 to the storage portion 153.
  • the collection chamber 130 and the storage chamber 140 in the clamp body mechanism 100 of the present application are connected (regardless of whether the clamp cup 110 is open or closed), ensuring that the telescopic member 150 and the tissue 300 thereon can be smoothly and unimpededly moved back and forth in the clamp body mechanism 100; the guide member 160 ensures the stability and directionality of the displacement of the telescopic member 150; each sampling can provide preparation for the next sampling, and the tissue 300 obtained after multiple samplings are arranged in sequence on the telescopic member 150, which is convenient for users to collect and mark.
  • the interior of the forceps cup 110 includes at least a collection chamber 130 , and a storage chamber 140 is formed between the proximal end 3 of the collection chamber and the proximal end 5 of the forceps seat or near the proximal end 5 of the forceps seat, ensuring that the storage chamber 140 is large enough.
  • the position of the collecting cavity 130 corresponds to the collecting portion 152 of the telescopic member 150
  • the position of the storage cavity 140 corresponds to the storage portion 153 of the telescopic member 150 .
  • the guide member 160 is disposed within the caliper mechanism 100 .
  • the guide 160 is disposed at the proximal end 6 of the clamp seat or near the proximal end 5 of the clamp seat.
  • the forceps cup 110 includes at least a collection chamber 130 therein, and a storage chamber 140 is formed between the proximal end 3 of the collection chamber and the distal end 161 of the guide.
  • the guide member 160 is disposed on the outer periphery of the telescopic member 150 , and the outer periphery of the guide member 160 can be slidably connected to the interior of the caliper mechanism 100 .
  • a first limiting member 154 located at the distal end side of the guide member 160 , or/and a second limiting member 155 located at the proximal end side of the guide member 160 are connected to the clamp body mechanism 100 .
  • the telescopic member 150 is a needle-shaped body, and the distal end 1502 of the telescopic member is in the shape of a needle tip, which can improve the collection efficiency.
  • the telescopic member 150 is provided with anti-slip protrusions 1511 and/or anti-slip depressions 1512 on its periphery to ensure that the tissue 300 is stably fixed on the telescopic member 150 .
  • the multi-sampling biopsy device 1000 also includes a sheath mechanism 200, the distal end 30 of the sheath mechanism is connected to the proximal end 4 of the clamp body mechanism, and includes a sheath 210.
  • the sheath 210 is internally provided with a telescopic driving member 211 connected to the proximal end 1503 of the telescopic member, and an opening and closing driving member 212 connected to the proximal end 2 of the clamp cup and capable of opening and closing the clamp cup 110.
  • the telescopic member 150 and the telescopic driving member 211 are detachably connected to facilitate taking out all samples after completing multiple samplings.
  • the telescopic member 150 and the telescopic driving member 211 are detachably connected via a release member 1550.
  • the guide member 160 is disposed on the clamp body mechanism 100, and the proximal end 162 of the guide member contacts the distal end 31 of the sheath tube. The contact between the guide member 160 and the sheath tube 210 can increase the stability of the guide member 160 itself and prevent the guide member 160 from loosening due to the frequent reciprocating movement of the telescopic member 150.
  • a multi-sampling biopsy device 1000 is provided, referring to FIGS. 1 to 9 , comprising:
  • the clamp body mechanism 100 includes a hinged clamp cup 110 and a clamp seat 120, and has a collection chamber 130 and a storage chamber 140 formed therein, which are adjacent and connected to each other.
  • the collection chamber 130 is located at the far end of the storage chamber 140, wherein the collection chamber 130 is used to accommodate newly collected tissue 300, and the storage chamber 140 is used to store the collected tissue 300;
  • the telescopic member 150 is specifically a needle-shaped body with a needle tip at the distal end and a barb structure 151 arranged on the periphery.
  • the telescopic member 150 is disposed in the clamp body mechanism 100.
  • the telescopic member 150 is provided with a collecting part 152 and a storage part 153.
  • the collecting part 152 is located at the distal end of the storage part 153.
  • the telescopic member 150 is driven so that the telescopic member 150 can be moved back and forth in the collecting cavity 130 and the storage cavity 140, so that the collecting part 152 collects the tissue 300 and the storage part 153 stores the tissue 300.
  • the guide member 160 is fixedly connected to the proximal end of the clamp seat 120, and the telescopic member 150 is slidably arranged through the guide member 160, so that the guide member 160 can guide the telescopic member 150 to move back and forth relative to the clamp body mechanism 100 in the proximal and distal directions;
  • the sheath tube mechanism 200 has a distal end connected to the proximal end of the clamp body mechanism 100, and a proximal end of the sheath tube mechanism 200 is connected to an operating mechanism 400, for example, as shown in FIG. 11 .
  • the sheath tube mechanism 200 includes a sheath tube 210 in contact with the proximal end of the guide member 160, and the sheath tube 210 is provided with a telescopic driving member 211 connected to the proximal end of the telescopic member 150, and an opening and closing driving member 212 connected to the proximal end of the clamp cup 110 to open and close the clamp cup 110.
  • the proximal ends of the telescopic driving member 211 and the opening and closing driving member 212 are connected to the operating mechanism 400;
  • the distal end of the telescopic member 150 can protrude from the distal end of the forceps cup 110 to open the forceps cup 110, and the tissue 300 at the collection portion 152 is stopped in the forceps cup 110, so that the tissue 300 moves toward the proximal end of the telescopic member 150 to the storage portion 153.
  • the distal end of the telescopic member 150 is placed inside the forceps cup 110 and close to the distal end of the forceps cup 110.
  • the telescopic member 150 can directly enter the tissue 300 without any other operations, and the operation process is simple; then the forceps cup 110 bites the tissue 300.
  • the distal end of the telescopic member 150 will not interfere with the opening and closing of the forceps cup 110; when the telescopic member 150 is displaced toward the distal side, the distal end of the telescopic member 150 can protrude beyond the distal end of the forceps cup 110, and the length protruding from the distal end of the forceps cup 110 is ⁇ 4 mm.
  • the clamp seat 120 includes a tube seat 121, and the tube seat 121 extends toward the distal side to form two connecting columns 122.
  • the clamp cup 110 includes a pair of cup bodies 111 and connecting pieces 112 that are integrally arranged.
  • the two cup bodies 111 are respectively hinged on the two connecting columns 122 through a connecting piece 112 and a pin 113, wherein the connected cup bodies 111, connecting pieces 112, and connecting columns 122 are located on the same side; ensuring that the collection chamber 130 and the storage chamber 140 are unobstructed.
  • the length of the tube seat 121 is greater than the length of the connecting column 122, ensuring that the storage chamber portion 141 sealed in the circumferential direction is relatively long, and the tissue 300 is not easily contaminated.
  • the cup mouth portion 1110 of the cup body 111 includes an end cutting edge 1111 located at the distal end of the cup body 111, side cutting edges 1112 extending from the end cutting edge 1111 toward the proximal side and located at both sides, and an open opening 1113 located at the proximal end of the cup body 111, wherein the end cutting edge 1111 and the side cutting edge 1112 are arranged continuously.
  • the open opening 1113 is designed to allow the collection chamber 130 and the storage chamber 140 to pass through without a stop; wherein the continuously arranged end cutting edge 1111 and the side cutting edge 1112 are sharp, and there is no gap after biting, and their shapes may be knife-shaped or saw-tooth-shaped.
  • the forceps cup 110 of the present embodiment includes a collection chamber 130 (specifically, a portion of the space inside the forceps cup 110 located at the distal end of the forceps cup 110), and a storage chamber 140 is formed between the proximal end of the collection chamber 130 and the guide member 160; wherein the position of the collection chamber 130 corresponds to the collection portion 152 of the telescopic member 150, and the position of the storage chamber 140 corresponds to the storage portion 153 of the telescopic member 150.
  • a first limiting member 154 located at the distal end of the guide member 160 and a second limiting member 155 located at the proximal end of the guide member 160 are fixedly connected to the telescopic member 150 .
  • a first stopper 154 is provided on at least the portion of the telescopic member 150 located at the distal end of the guide member 160.
  • the telescopic member 150 is provided with a first stopper 154 located at the distal end of the guide member 160, or/and a second stopper 155 located at the proximal end of the guide member 160.
  • the first stopper 154 and the second stopper 155 can limit the displacement stroke of the telescopic member 150 in one direction respectively, and when the first stopper 154 and the second stopper 155 are combined, the stroke of the telescopic member 150 can be limited in two directions, which is convenient for users to judge and control sampling, improve efficiency, and ensure sampling safety; wherein the restriction in the distal direction can prevent the telescopic member distal end 1502 from protruding too much and damaging the inner tissue, and the restriction in the proximal direction can prevent the tissue 300 from being squeezed or falling off by other components.
  • the telescopic member 150 is detachably connected to the telescopic driving member 211 via a release member 1550.
  • the release member 1550 is a connecting tube 1551.
  • a connecting tube 1551 is provided on the portion of the telescopic member 150 located on the proximal side of the guide member 160.
  • the connecting tube 1551 is directly the same component as the second stopper 155 used to limit the displacement stroke of the telescopic member 150 toward the distal end, that is, one component realizes two functions.
  • the release member 1550 and the second stopper 155 are combined into one to simplify the structure.
  • the telescopic member 150 and the connecting tube 1551 are interference fit and can be pressed against each other in the opposite direction between the first limit member 154 and the guide member 160 until the connecting tube 1551 releases the telescopic member 150, or/and, the connecting tube 1551 and the telescopic driving member 211 are interference fit and can be pressed against each other in the opposite direction between the first limit member 154 and the guide member 160 until the telescopic member 150 is released by the release of the connecting tube 1551 and the telescopic driving member 211.
  • a multi-sampling method using the multi-sampling biopsy device 1000 includes the following specific steps:
  • S5 Repeat S1 to S4 to complete N times of tissue sampling.
  • N is a positive integer greater than or equal to 2.
  • the first tissue 301 is located at the proximal side of the second tissue 302;
  • the sampled tissue 300 is located on the distal side of the tissue 300 sampled the previous time.
  • the present application arranges the tissues 300 obtained by multiple samplings in sequence on the telescopic member 150, which is easy to operate and does not require repeated opening and closing of the forceps cup 110, driving of the telescopic member 150, etc., thereby effectively avoiding misoperation and improving the efficiency and accuracy of multiple sampling.
  • operation S6 is performed:
  • the tissues 300 obtained by multiple samplings are sequentially arranged on the telescopic member 150, which is convenient for the user to collect and mark.
  • the present application provides a sampling device 2000, which may include: an operating mechanism 400 and a multi-sampling biopsy device 1000.
  • the multi-sampling biopsy device 1000 may be the multi-sampling biopsy device 1000 of the aforementioned embodiment.
  • the clamp body mechanism 100 and the telescopic member 150 are respectively driven by the operating mechanism 400.
  • the sampling device 2000 further includes a driving member 430, and the multi-sampling biopsy device 1000 is driven by the operating mechanism 400 through the driving member 430.
  • the sampling device 2000 of the present application can achieve multiple sample sampling in a single entry and exit.
  • the present application provides an operating mechanism 400 , which has the following advantages: it can realize the sampling of multiple samples in a single entry and exit, without the need for doctors to frequently enter and exit, thereby improving operating efficiency, reducing operation time, reducing patient pain, and improving sampling accuracy.
  • the operating mechanism 400 of the present application is a structure that can control the independent movement of the distal component 101, so that it can be continuously operated, such as continuous sampling, so that it can quickly complete multiple sampling of the same lesion or the same biopsy in a single entry and exit, thereby improving operation efficiency, reducing operation time, and reducing patient pain.
  • the distal component 101 can be a forceps cup 110 or a telescopic member 150.
  • the present application provides an operating mechanism 400, which can be an operating handle.
  • the operating mechanism 400 includes a handle body 410 and a plurality of control members 420, wherein the plurality of control members 420 are movably connected to the handle body 410, and each control member 420 is connected to a driving member 430, and the driving member 430 is used to connect the distal component 101.
  • each control member 420 can reciprocate relative to the handle body 410 along a first direction, and each control member 420 has a movement tendency to reset toward one side along the first direction, and each control member 420 can drive the corresponding driving member 430 to move synchronously and then drive the distal component 101 to move.
  • the direction where the distal end and the proximal end of the handle body 410 are located is the first direction, also called the distal-proximal direction.
  • each control member 420 can independently reciprocate along the first direction relative to the handle body 410, and each control member 420 has a motion tendency to independently reset toward one side along the first direction, so that the control member 420 can independently and automatically return to the initial state after each action; that is, each control member 420 can independently act without interfering with or affecting each other, so that the distal member 101 corresponding to each control member 420 can not interfere with each other, so that the distal member 101 corresponding to each control member 420 can continue to work.
  • one of the distal members 101 is used as a sampling structure, such as a sampling needle, multiple operations can be performed to meet the sampling of multiple samples when entering the lesion area at a single time, so that the doctor does not need to frequently enter and exit the human body, which improves the operation efficiency, reduces the operation time, and reduces the pain of the patient.
  • multiple control members 420 are arranged at intervals along the first direction.
  • multiple control members 420 are distributed on their respective moving paths relative to the handle body 410, reducing the force components along other directions, making it easier to control; on the other hand, such an arrangement makes full use of the space of the handle body 410 along the first direction and reduces the space along other directions; especially when the first direction is the axial direction of the handle body 410, the space occupied by the operating mechanism 400 along the radial direction of the handle body 410 is reduced.
  • multiple control members 420 can also be arranged at intervals along the radial direction of the handle body 410.
  • the plurality of control members 420 are along the first direction (i.e., the moving direction, which may also be the axial direction of the handle body 410), in order to reduce the interference between the driving member 430 and the control member 420, at least the control member 420 located near the distal end is configured with a first through hole for guiding the driving member 430 corresponding to the control member 420 located near the proximal end to pass through. In this way, not only is it ensured that the driving member 430 corresponding to each control member 420 extends along the first direction, reducing the transmission path, but also the first through hole is used to guide the movement of the driving member 430.
  • each control member 420 along the first direction is arranged in an "I" shape, which is convenient for the doctor to hold and operate.
  • the number of control members 420 is two, namely a first control member 4201 and a second control member 4202.
  • the first control member 4201 is connected to the clamp
  • the second control member 4202 is connected to the sampling needle.
  • the first control member 4201 corresponds to the opening and closing driving member 212 to meet the opening and closing of the clamp
  • the second control member 4202 corresponds to the telescopic driving member 211 to meet the telescopic of the sampling needle.
  • the first control member 4201 is located near the distal end, and the second control member 4202 is located near the proximal end. At this time, the first control member 4201 is configured with a first through hole to guide the telescopic drive member 211 to pass through.
  • the first control member 4201 can move toward the distal end to drive the clamp to open through the opening and closing drive member 212; and the first control member 4201 can have a movement tendency toward the proximal end to drive the clamp to close through the opening and closing drive member 212.
  • the second control member 4202 moves toward the distal end to drive the sampling needle to extend out of the clamp through the telescopic drive member 211; and the second control member 4202 has a movement tendency toward the proximal end to drive the sampling needle to retreat through the telescopic drive member 211. This is just an example.
  • each control member 420 is connected with an elastic member 450, and the elastic member 450 is used to drive the corresponding control member 420 to reset toward the proximal end.
  • the elastic member 450 is connected between the corresponding control member 420 and the handle body 410.
  • the control member 420 moves toward the distal end to cause the elastic member 450 to deform, so as to apply a force toward the proximal end, so that the control member 420 has a movement tendency to move toward the proximal end and reset; that is, at this time, the elastic member 450 can be a compression spring.
  • the proximal end of the control member 420 can also be connected with the elastic member 450.
  • the elastic member 450 can be a tension spring; or, the proximal end and the distal end 27 of the control member 420 are both provided with elastic members 450, the proximal end is a tension spring, and the distal end is a compression spring.
  • control member 420 may move toward the proximal end to drive the distal member 101 to work, and move toward the distal end to drive the distal member 101 to reset; in this case, the elastic member 450 is used to drive the corresponding control member 420 to reset toward the distal end to meet the reset of the distal member 101.
  • the specific setting method needs to be adjusted according to the actual structure of the distal member 101.
  • the aforementioned near the proximal end and near the distal end are both relative positions between the multiple control members 420.
  • the second control member 4202 is closer to the proximal end than the first control member 4201
  • the first control member 4201 is closer to the distal end than the second control member 4202
  • the first control member 4201 is configured with a first through hole for the telescopic drive member 211 to penetrate.
  • control members when there are three control members, they are divided into a first control member, a second control member, and a third control member.
  • the second control member and the third control member are closer to the distal end than the first control member, and the third control member is closer to the distal end than the second control member; conversely, the second control member and the first control member are closer to the proximal end than the third control member, and the first control member is closer to the proximal end than the second control member.
  • the second control member and the third control member are both provided with a first through hole, and the first through hole on the second control member is used to penetrate the driving member corresponding to the first control member, and the first through hole on the third control member is used to penetrate the driving member corresponding to the first control member and the second control member.
  • the clamp and the sampling needle enter the human body, the impact on the patient's lesion area needs to be considered. If the clamp is opened, the wound will be damaged, causing discomfort to the patient. In addition, if the sampling needle extends too much relative to the clamp, the clamp may be positioned backward relative to the lesion area, making it inconvenient to take samples. Therefore, in actual use, the clamp is closed and the sampling needle is positioned backward relative to the clamp, which can be used as the initial position.
  • At least one limiting seat 440 is provided on the handle body 410, each control member 420 corresponds to at least one limiting seat 440, and each limiting seat 440 and each control member 420 are arranged at intervals along the first direction.
  • one control member 420 corresponds to one limiting seat 440, so as to limit the movement of the control member 420 and avoid excessive movement of the distal member 101; and, it is precisely because of the limiting effect of the limiting seat 440 that the movement interference between each control member 420 can be avoided.
  • each control member 420 and each limiting seat 440 are arranged alternately, and each limiting seat 440 is located on the side close to the distal end relative to the corresponding control member 420; in this way, while satisfying the movement limit of each control member 420 toward the distal end, the movement interference between any two adjacent control members 420 is avoided to affect the operation of the corresponding distal member 101, ensuring that each distal member 101 operates independently.
  • the first control member 4201 corresponds to the first limit seat 441, which is located at the distal end of the first control member 4201
  • the second control member 4202 corresponds to the second limit seat 442, which is located at the distal end of the second control member 4202, so as to limit the movement of the first control member 4201 and the second control member 4202 toward the distal end.
  • each limit seat 440 is located near the distal end compared to the corresponding control member 420, a second through hole 4401 is constructed on each limit seat 440 to guide the corresponding driving member 430 to pass through the second through hole 4401 to avoid interference. Moreover, such a setting can also guide the movement of each driving member 430.
  • the limit seat 440 can also be located at a position close to the proximal end of the corresponding control member 420, or a limit seat 440 is provided at the proximal and distal ends of each control member 420.
  • each stopper 440 is configured with a positioning groove 4402 on one end surface facing the corresponding control member 420, and one end of the corresponding elastic member 450 can be deeply inserted into the positioning groove 4402 to play a positioning role in the assembly of the elastic member 450.
  • a positioning column 4403 may be constructed on one end face of each limit seat 440 facing the corresponding control member 420, and the corresponding elastic member 450 may be sleeved on the positioning column 4403; or, it may be a combination of the positioning groove 4402 and the positioning column 4403, in which case the positioning column 4403 is located in the positioning groove 4402, and the elastic member 450 is sleeved on the outer side of the positioning column 4403 and partially located in the positioning groove 4402.
  • the first control member 4201 corresponds to the first elastic member 451, and the first elastic member 451 is connected between the first control member 4201 and the first limiting seat 441;
  • the second control member 4202 corresponds to the second elastic member 452, and the second elastic member 452 is connected between the second control member 4202 and the second limiting seat 442.
  • the structure on the first limiting seat 441 for positioning and assembling the first elastic member 451 and the structure on the second limiting seat 442 for positioning and assembling the second elastic member 452 can be the same or different, as long as they meet the positioning and assembly of the corresponding elastic member 450.
  • a release space 4103 is constructed on the handle body 410 on the side of at least one control member 420 toward the proximal end, providing space for the control member 420 to move when the distal component 101 is released relative to the corresponding drive member 430.
  • the second control member 4202 is connected to the sampling needle through the telescopic drive member 211, and the sampling needle needs to be released relative to the telescopic drive member 211 to facilitate the collection of samples on the sampling needle.
  • the second control member 4202 is required to drive the telescopic drive member 211 to move toward the proximal end to release the sampling needle, so the partial area on the handle body 410 located at the proximal end of the second control member 4202 can be used as the release space 4103.
  • the specific release method will be detailed in the subsequent content.
  • each control member 420 is configured with a connecting hole 421, and the proximal portion of each driving member 430, that is, the proximal end 21 of the driving member, can be directly connected to the hole wall of the connecting hole 421 to meet the driving of the driving member 430 by the control member 420.
  • the direct connection method simplifies the assembly steps and improves the assembly efficiency.
  • the proximal portion of each driving member 430 can be indirectly connected to the hole wall of the connecting hole 421, that is, the driving member 430 can be connected to the corresponding control member 420 into an integral structure through a transition component to realize the driving of the driving member 430 by the control member 420. With such a setting, when one of the control member 420 and the driving member 430 is damaged, it can be repaired by disassembling the transition component to improve the protection.
  • each driving member 430 is connected with a rod-shaped connecting portion 4311, and the proximal portion of each driving member 430 is plugged into the connecting hole 421 of the corresponding control member 420 through the rod-shaped connecting portion 4311; that is, the driving member 430 is indirectly connected to the corresponding control member 420.
  • the rod-shaped connecting portion 4311 has a certain structural hardness, which can guide the movement of the driving member 430.
  • the rod-shaped connecting portion 4311 can be a hollow structure, one end of which is inserted into the connecting hole 421, and the other end is connected to the driving member 430.
  • the connecting hole 421 is configured with a bending section 422 extending along the second direction, and the rod-shaped connecting portion 4311 is configured with a hook section 4312, and the hook section 4312 is inserted into the bending section 422.
  • the second direction is at an angle to the first direction; or the extending direction of the bending section 422 is set at an angle or is not parallel to the distal and proximal directions.
  • the second direction can be the radial direction of the handle body 410, that is, the connecting hole 421 is set in a "T" shape or an "L" shape.
  • the bending section 422 can be a circular arc groove with the center of the circle located on the axis of the connecting hole 421, or it can be a circular hole.
  • the end of the rod-shaped connecting portion 4311 is plugged into the connecting hole 421 and positioned by the friction between the outer wall of the rod-shaped connecting portion 4311 and the hole wall of the connecting hole 421; of course, both can be provided with cooperating rough textures to improve the connection reliability.
  • each elastic member 450 can be sleeved on the outer side of the corresponding rod-shaped connecting portion 4311 .
  • connection hole 421 located at the first control member 4201 can also be set as a through hole that penetrates along the first direction, so that the telescopic driving member 211 connected to the second control member 4202 can pass through the connection hole 421 to connect with the distal component 101.
  • the first control member 4201 can also be provided with a first through hole and a connection hole 421, and the two are arranged at intervals.
  • the corresponding first through hole and the connection hole 421 are connected, that is, the first control member 4201 is configured with a through hole that penetrates along the first direction, and the through hole is used to connect with the corresponding rod-shaped connection.
  • the connecting portion 4311 is connected and used for the insertion of the telescopic driving member 211.
  • the corresponding bending section 422 is located in the middle of the through hole and close to the proximal end of the first control member 4201, thus forming a "cross" shape.
  • the driving member 430 is connected to the corresponding control member 420 by the rod-shaped connecting portion 4311, as far as the limiting seat 440 is concerned, the end of the rod-shaped connecting portion 4311 away from the control member 420, i.e., the distal end 23 of the rod-shaped connecting portion, is penetrated in the corresponding limiting seat 440. Since the limiting seat 440 is configured with a second through hole 4401 for guiding the driving member 430 to penetrate, at this time, the rod-shaped connecting portion 4311 can be penetrated in the second through hole 4401.
  • the two ends of the rod-shaped connecting portion 4311 are respectively constrained by the hole wall of the connecting hole 421 and the hole wall of the second through hole 4401, which not only guides the movement of the rod-shaped connecting portion 4311 with the control member 420, but also limits the assembly of the rod-shaped connecting portion 4311, and avoids the shaking or displacement of the rod-shaped connecting portion 4311 as much as possible, thereby improving the operation accuracy.
  • the portion of the control member 420 located in the guide slot 4102 can move in the guide slot 4102 to guide the movement of the control member 420.
  • the arrangement of the assembly cavity 4101 can protect the driving member 430, preventing the driving member 430 from being damaged and affecting the distal component 101.
  • the gripping rod body 411 the above-mentioned limit seat 440 can be installed in the assembly cavity 4101, and part of the limit seat 440 can also extend from the guide slot 4102; and the rod-shaped connecting portion 4311 is located in the assembly cavity 4101 to achieve connection with the control member 420 and the driving member 430.
  • the handle body 410 also includes a connecting sleeve 412 connected to the distal end of the gripping rod body 411, and the connecting sleeve 412 is configured with a connecting cavity 4121 that is connected to the assembly cavity 4101.
  • Each driving member 430 can extend from the assembly cavity 4101 and the connecting cavity 4121 to facilitate the connection of the distal component 101.
  • the setting of the connecting sleeve 412 is not only convenient for the handle body 410 to cooperate with other structures, but also equivalent to extending the length of the handle body 410, and is more convenient for the cooperation of the driving member 430 and the control member 420, and even more groups can be set.
  • the fixing tube can be used to limit the distal movement of the distal control member 420 (e.g., the first control member 4201) while satisfying the connection with other structures.
  • the fixing tube can be used as a limiting seat 440 to satisfy the dual effects of connection and limiting, thereby simplifying the internal structure of the operating mechanism 400.
  • an elastic member 450 i.e., a first elastic member 451 can be connected between the fixing tube and the first control member 4201 to ensure that the first control member 4201 is normally reset.
  • the fixing tube serves as the first limiting seat 441.
  • a positioning column 4403 is protruded from the proximal end of the fixing tube, and the end portion of the first elastic member 451 is sleeved on the outer side of the positioning column 4403.
  • the distal end of the operating mechanism 400 i.e., the distal end 28 of the operating mechanism, is connected to the sheath 210, and each driving member 430 is disposed in the sheath 210.
  • each driving member 430 can be limited, so that each driving member 430 can only move in the axial direction as much as possible to act on the corresponding distal component 101.
  • each driving member 430 includes a traction rope 431. At this time, one end of each traction rope 431 is connected to the corresponding control member 420, and the other end is connected to the corresponding distal part 101.
  • the distal part 101 has only one operating head, such as a sampling needle, which only needs to drive the sampling needle to extend or retract along its own axis.
  • some driving members 430 include multiple traction ropes 431, the proximal ends of the multiple traction ropes 431, that is, the proximal ends 25 of the traction ropes are respectively connected to a control member 420, or a main rope 433 is connected to the proximal ends of the multiple traction ropes 431 through a coupling member 432, and the proximal end of the main rope 433 is connected to a control member 420.
  • a main rope 433 is connected to the proximal ends of the multiple traction ropes 431 through a coupling member 432, and the proximal end of the main rope 433 is connected to a control member 420.
  • an embodiment of the present application further provides a sampling device 2000, comprising the above-mentioned operating mechanism 400, a distal component 101, and a driving member 430 connected to the operating mechanism 400 and the distal component 101.
  • the distal component 101 comprises a clamp body mechanism 100, a telescopic member 150, and a guide member 160.
  • the clamp body mechanism 100 comprises a clamp seat 120 and a clamp cup 110 movably connected to the clamp seat 120, and the clamp body mechanism 100 is formed with a collection cavity and a storage cavity which are adjacent and through-set, and the collection cavity is located at the distal end of the storage cavity;
  • the telescopic member 150 is disposed inside the clamp body mechanism 100, and the telescopic member 150 is provided with a collection part and a storage part, and the collection part is located at the distal end of the storage part, and the telescopic member 150 can reciprocate in the collection cavity and the storage cavity, so that the collection part collects tissue and the storage part stores tissue.
  • the guide member 160 is disposed on the outer periphery of the telescopic member 150 to guide the reciprocating movement of the telescopic member 150 relative to the clamp mechanism 100 in the distal and proximal directions.
  • the forceps cup traction member mentioned above is the opening and closing drive member 212
  • the forceps cup control member is the first control member 4201
  • the telescopic traction member is the telescopic drive member 211
  • the telescopic control member is the second control member 4202.
  • the opening and closing mentioned above refers to opening and closing.
  • the clamp body mechanism 100 includes at least two clamp cups 110, at least two clamp cups 110 are hinged to the clamp seat 120, and each clamp cup 110 is configured with a cup mouth portion 1110.
  • the distal end of the cup mouth portion 1110 is configured with a guide groove 1118, which passes through the outer surface of the clamp cup 110 or is located on the distal inner surface of the clamp cup 110. Since the telescopic member 150 needs to open the clamp cup 110 when moving, the guide groove 1118 is used to guide the movement of the telescopic member 150 relative to the clamp cup 110, which is more convenient for the telescopic member 150 to apply force.
  • cup mouth portion 1110 is configured as a flat mouth type or a sawtooth type or both structures. According to different lesion areas, a matching forceps cup 110 can be selected to facilitate the clamping and biting of the forceps cup 110 to separate the sample.
  • the clamp cup 110 is configured with a hinge hole 1117, so as to facilitate the hinged connection with the clamp seat 120 by means of the pin 113; and each clamp cup 110 is provided with a fixing hole 1116 at the proximal end, and a traction rope 431 is connected to the clamp cup 110 to facilitate driving the clamp cup 110 to rotate relative to the clamp seat 120 to achieve opening and closing.
  • the clamp cup 110 is provided with a storage cavity 1114 to facilitate defining a collection cavity; and the clamp seat 120 is hollow so as to facilitate The storage chamber is formed by cooperating with the clamp cup 110.
  • the clamp cup 110 is also provided with a drainage hole 1115, which is connected to the collection chamber to allow the blood remaining in the collection chamber to flow out during sampling.
  • the telescopic member distal end 1502 serves as a collection portion for piercing the lesion area, and the storage portion is arranged on the needle body 1521, and is provided with a plurality of barb structures 151. Specifically, along the axial direction of the needle body 1521, the area between any two adjacent barb structures 151 can be used to store samples. Since each barb structure 151 is arranged obliquely, the sample can move from the distal end to the proximal end, and the movement of the sample from the proximal end to the distal end is limited.
  • a first stopper 154 is configured on one side of the telescopic member 150 located at the proximal end of the storage portion, and the first stopper 154 can abut against the distal end surface of the guide member 160 to position, assemble and limit the movement of the telescopic member 150, ensuring that the telescopic member 150 has sufficient space to serve as a storage portion; and when the first stopper 154 abuts against the guide member 160, it can be used to release the telescopic member 150 relative to the driving member 430.
  • the first stopper 154 can be a stopper boss protruding radially outwardly along the telescopic member 150.
  • the first stopper 154 is located on the side of the guide member 160 toward the distal end, and the connecting tube 1551 is arranged on the side of the guide member 160 toward the proximal end. At this time, the first stopper 154 can abut against the guide member 160 to limit the movement of the telescopic member 150 toward the proximal end, and the connecting tube 1551 can abut against the guide member 160 to limit the movement of the telescopic member 150 toward the distal end.
  • the second control member 4202 can be driven to move toward the proximal end, so that the first stopper 154 abuts against the guide member 160 and is restricted; as the force applied to the second control member 4202 gradually increases, because of the limiting effect of the guide member 160 on the first stopper 154, the telescopic member 150 can be disengaged from the telescopic driving member 211, thereby realizing the release of the telescopic member 150.
  • the above-mentioned release space 4103 is the area that satisfies the movement of the second control member 4202 toward the proximal end.
  • the small-diameter disconnection portion 156 When released, the small-diameter disconnection portion 156 can weaken the strength of the telescopic member 150 at this location, and under a large pulling force, the telescopic member 150 can be disconnected from the small-diameter disconnection portion 156 relative to the telescopic driving member 211 and released. Alternatively, as the force of driving the second control member 4202 increases, the telescopic member 150 and the telescopic driving member 211 are disconnected at the connecting tube 1551 and released.
  • an embodiment of the present application further provides a sampling method, which performs a sampling operation based on the above-mentioned sampling device 2000.
  • the sampling method includes the following steps:
  • the distal end of the telescopic member 150 is located at the forceps cup 110 and close to the distal end of the forceps cup 110.
  • the first control member 4201 is driven to move toward the distal end, driving the forceps cup 110 to open, so that the collection portion at the distal end of the telescopic member 150 enters the tissue 300;
  • S50 repeat S1 to S4 to complete N times of tissue sampling
  • the elastic member 450 drives the control member 420 to move toward the proximal side for resetting, and the control member 420 can be manually pushed by the doctor when moving toward the distal side.
  • the initial state is that the first elastic member 451 and the second elastic member 452 corresponding to the first control member 4201 and the second control member 4202 are 452 are in a natural state, in which the user causes the sheath 210 to extend into the lesion area, and the telescopic member 150 is located in the forceps cup 110 to avoid puncturing other areas during the extension process.
  • the first control member 4201 When the forceps body structure extends into a specific area to be sampled under the action of the sheath 210, the first control member 4201 can be pushed to move toward the distal side, and the first control member 4201 drives the two forceps cups 110 to rotate relative to the forceps seat 120 through the opening and closing driving member 212 to open, exposing the telescopic member 150 located in the forceps cup 110, and the collection portion at the distal end of the telescopic member 150 can penetrate the tissue 300 under the action of external force. After a certain penetration, the driving force acting on the first control member 4201 is cancelled, and the first control member 4201 moves toward the proximal side under the resetting action of the first elastic member 451.
  • the opening and closing driving member 212 drives the two forceps cups 110 to rotate again and close, and the cup mouth parts 1110 of the two forceps cups 110 cooperate with each other to separate the tissue so that the tissue remains on the telescopic member 150.
  • the second control member 4202 is pushed to move toward the distal side, so that the distal end of the telescopic member 150 extends through the guide groove 1118 to open the two closed forceps cups 110; however, at this time, the first control member 4201 only bears the force of the first elastic member 451, so the two forceps cups 110 still have the force to clamp the telescopic member 150; in this way, as the telescopic member 150 moves toward the distal side, the tissue on the telescopic member 150 is stopped by the forceps cup 110 in the collection chamber 130, and moves to the storage part 153 of the telescopic member 150, so that the collection part 152 is empty and convenient for the next operation.
  • the driving force acting on the second control member 4202 is canceled, and the second control member 4202 moves toward the proximal side under the action of the second elastic member 452, so that the telescopic member 150 returns to the initial state; at the same time, the tissue 300 located in the storage part 153 moves toward the proximal end synchronously with the telescopic member 150 to enter the storage chamber 140.
  • the second control member 4202 is pulled toward the proximal side, and the second control member 4202 drives the telescopic member 150 to move toward the proximal end through the telescopic driving member 211, and the pulling force is slowly increased during the pulling process until the first stop member 154 on the telescopic member 150 abuts against the guide member 160 in the clamp seat 120; the pulling force is further increased until the telescopic member 150 is released relative to the telescopic driving member 211. Then the user can remove the telescopic member 150, so as to remove and collect N sample tissues on the telescopic member 150 at one time.
  • This type of operation does not require multiple entries and exits of the human body. Instead, continuous sampling of multiple samples can be performed with just one entry, which improves operational efficiency, shortens surgical time, and reduces pain and discomfort for patients.

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Abstract

L'invention concerne un dispositif de biopsie à échantillonnage multiple (1000), un procédé d'échantillonnage multiple et un appareil d'échantillonnage (2000). Le dispositif de biopsie à échantillonnage multiple (1000) comprend un mécanisme de corps de forceps (100), un élément télescopique (150) et un élément de guidage (160), le mécanisme de corps de forceps (100) comprenant une coupelle de forceps (110) et un support de forceps (120), le mécanisme de corps de forceps (100) étant pourvu d'une chambre de collecte (130) et d'une chambre de stockage (140) ; l'élément télescopique (150) est pourvu d'une partie de collecte (152) et d'une partie de stockage (153), et l'élément télescopique (150) peut être entraîné pour se déplacer en va-et-vient dans la chambre de collecte (130) et la chambre de stockage (140), de façon à amener la partie de collecte (152) à collecter un tissu (300) et à amener la partie de stockage (153) à stocker le tissu (300) ; et l'élément de guidage (160) est configuré pour guider l'élément télescopique (150) à se déplacer en va-et-vient dans une direction proximale ou distale par rapport au mécanisme de corps de forceps (100).
PCT/CN2024/098988 2023-06-13 2024-06-13 Dispositif de biopsie à échantillonnage multiple, procédé d'échantillonnage multiple et appareil d'échantillonnage Pending WO2024255796A1 (fr)

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CN202310698497.8 2023-06-13
CN202311109750.8A CN117297672A (zh) 2023-08-30 2023-08-30 操作手柄、取样装置以及取样方法
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CN119437788A (zh) * 2025-01-07 2025-02-14 中国科学院大学 多通道组织取样器及其取样方法

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