WO2024254346A1 - Engineered viral like particles (evlps) for the selective transduction of target cells - Google Patents

Abstract

The present disclosure provides compositions and methods for the selective transduction and genome editing of human cells (e.g., hematopoietic stem and progenitors cells, HSPCs) using engineered viral like particles (eVLPs). Aspects of the disclosure provide eVLP compositions comprising fusion proteins comprising a targeting moiety. In some embodiments, the fusion proteins comprise a cytokine conjugated to a transmembrane protein and/or an envelope glycoprotein. In other embodiments, the fusion proteins comprise a targeting moiety domain, a stalk protein domain, a transmembrane and/or envelope glycoprotein domain. Targeted-eVLP architectures comprising various targeting domains, stalk domains, transmembrane domains, and envelope glycoproteins are also provided herein. Other aspects of the disclosure provide eVLP compositions comprising envelope glycoproteins comprising non-natural sugars and methods of conjugating said eVLPs to various targeting moieties using bio-orthogonal click chemistry. Polynucleotides, vectors, cells, and kits useful for producing the articles, and performing the methods, described herein are also provided.

Description

ENGINEERED VIRAL LIKE PARTICLES (EVLPS) FOR THE SELECTIVE TRANSDUCTION OF TARGET CELLS

GOVERNMENT SUPPORT

[001] This invention was made with government support under Grant Nos. UG3AI150551, U01AI142756, R35GM118062, RM1HG009490, and R01EY009339 awarded by the National Institutes of Health. The government has certain rights in the invention.

BACKGROUND OF INVENTION

[002] Recently developed gene editing agents, such as base editors and prime editors, enable the precise manipulation of genomic DNA in living organisms and raise the possibility of treating the root cause of many genetic diseases. The broad therapeutic application of in vivo gene editing requires safe and efficient means for delivering gene editing agents to multiple tissues and organs. Many of the most robust approaches for delivering gene editing agents in vivo reported to date involve the use of viruses, such as adeno-associated viruses (AAVs) or lentiviruses (LV), to deliver DNA encoding a gene editing agent to target tissues. However, viral delivery of DNA encoding editing agents leads to prolonged expression in transduced cells, which could increase the frequency of off-target editing. In addition, viral delivery of DNA raises the possibility of viral vector integration into the genome of transduced cells, both of which can potentially promote oncogenesis or other adverse effects. Further, despite the constant development of transfection methods and the optimization of viral and nonviral delivery vectors (e.g., AAV or LV), the efficiency of these approaches can vary dramatically, especially in primary cells that are highly sensitive to changes in their environment and may be altered in response to transfection agents and/or vectors. This effect is further exacerbated in vivo when pharmacokinetics significantly limits the accessibility of certain cell types to circulating delivery vectors.

[003] More recently, virus-like particles (VLPs) have been engineered to deliver, for example, Cas9 proteins, base editors, and prime editors. These VLPs allow the delivery of ribonucleoproteins (RNPs) (e.g., a gene editing protein agent complexed with a guide RNA) instead of DNA to target cells. The short half-life of RNPs in cells limits the opportunity for off-target editing. These VLPs, however, utilize wild-type viral fusogen proteins, which have been optimized by natural evolution to transduce many different cell types. This property, which yields highly infectious VLPs, increases transduction of non-target cell types when used in vivo due to the wide natural tropism of the wild-type viral fusogen. This can be problematic when targeted gene editing (e.g., gene editing of a specific cell type) is desired. Thus, improvements are needed.

SUMMARY OF INVENTION

[004] The present disclosure provides compositions of engineered virus like particles (eVLPs) and eVLP complexes for the selective transduction and genome editing of human cells (e.g., hematopoietic stem and progenitor cells, HSPCs). Polynucleotides encoding the proteins of the eVLP and eVLP complexes, vectors comprising said polynucleotides, cells comprising the polynucleotides and/or vectors, and kits useful for producing the eVLPs and eVLP complexes are also provided. Additionally, methods of preparing eVLPs and eVLP complexes are also disclosed herein, as are methods for editing a nucleic acid molecule using said eVLPs and/or eVLP complexes. Other aspects relate to methods of delivering a cargo (e.g., a therapeutic) of interest to a target cell. For example, in some embodiments, the methods relate to using the eVLPs disclosed herein to deliver a base editor or a prime editor to a target cell to treat a disease or disorder.

[005] Aspects of the disclosure relate to eVLPs. In some embodiments, the eVLPs disclosed herein are formed via supra-molecular assembly and comprise (a) an envelope comprising (i) a lipid membrane (e.g., single-layer or bi-layer membrane) and a (ii) viral envelope glycoprotein; and (b) a multi-protein core region enclosed by the envelope and comprising (i) a Gag protein, (ii) a Gag-Pro-Pol protein, and (iii) a Gag-cargo fusion protein (e.g., a second fusion protein) comprising a Gag protein fused to a cargo protein (e.g., a napDNAbp, base editor, or prime editor, or therapeutic protein) via a cleavable linker (e.g., a protease-cleavable linker). As described in more detail below, in some embodiments, a transmembrane domain is conjugated to a targeting domain. In other embodiments, the envelope glycoprotein is conjugated to the targeting domain.

[006] Some aspects of the disclosure relate to eVLP compositions comprising fusion proteins comprising a targeting moiety. In some embodiments, the fusion proteins comprise a cytokine conjugated to a transmembrane protein and/or an envelope glycoprotein of the eVLP. In other embodiments, the fusion proteins comprise a targeting moiety domain, a stalk protein domain, and a transmembrane domain, and/or optionally, an envelope glycoprotein domain. Targeted-eVLP architectures comprising various combinations of targeting domains (e.g., facilitates targeted binding of the eVLP to a target cell), stalk domains (e.g., inert domains that act as spacer sequences), transmembrane domains (e.g., a peptide that spans across the lipid membrane domain of the eVLP), and/or envelope glycoproteins (e.g., proteins that facilitate binding of the eVLP to multiple cell targets). Other aspects of the disclosure provide eVLP compositions comprising envelope glycoproteins comprising non-natural moieties and methods of conjugating said eVLPs to various targeting moieties using chemistry, e.g., bio-orthogonal click chemistry.

[007] As described herein, the inventors have discovered that eVLP compositions comprising targeting moieties on their surfaces (e.g., as fusion proteins comprising the viral envelope glycoprotein and/or transmembrane proteins) are capable of delivering payloads to specific cell types, both in vitro and in vivo, with higher transduction efficiencies than eVLPs lacking said targeting moieties.

[008] Thus, in certain aspects, the present disclosure relates to eVLPs comprising one or more fusion proteins capable of displaying a targeting domain on the surface of eVLP. In some embodiments, the fusion protein comprises a transmembrane domain and a targeting domain. In some embodiments, the fusion protein comprises a transmembrane domain, a stalk domain, and a targeting domain. In other embodiments, the fusion protein comprises a viral envelope domain and a targeting domain. Alternatively, or additionally, the fusion protein comprises a viral envelope domain, a stalk domain, and a targeting domain.

[009] Any two domains within the fusion protein may be optionally linked together using one or more linkers (e.g., cleavable linkers), according to some embodiments. For example, in one set of embodiments, a first linker (e.g., cleavable linker) connects the transmembrane domain and the targeting domain. In another set of embodiments, the first linker (e.g., cleavable linker) connects the transmembrane domain and the stalk domain. In a third set of embodiments, the first linker (e.g., cleavable linker) connects the stalk domain to a targeting domain. In yet another set of embodiments, a second linker (e.g., cleavable linker) connects the stalk domain to a targeting domain.

[0010] In some embodiments, the one or more linkers comprises a stalk domain. For example, in some cases, a stalk domain connects the transmembrane domain and the targeting domain.

[0011] In some embodiments, a first linker (e.g., linker) connects a viral envelope glycoprotein domain and the targeting domain. In another set of embodiments, the first linker (e.g., linker) connects the viral envelope glycoprotein domain and the stalk domain. In a third set of embodiments, the first linker (e.g., linker) connects the stalk domain to a targeting domain. In yet another set of embodiments, a second linker (e.g., linker) connects the stalk domain to a targeting domain.

[0012] In certain embodiments, the fusion protein comprises a transmembrane domain, an optional linker (e.g., linker), and a targeting domain (e.g., any domain capable of binding a target receptor on a target cell). Exemplary receptortargeting domains contemplated herein include, but are not limited to, CD110:Thrombopoientin (TPO), c-kit:Stem Cell Factor (SCF), CXCR4:CXCL12, CD46:Adenovirus F35 (AdF35), CD201:Protein C, CD150:SH2DlA/EAT-2, CD45:CMV ULll/PP14/adenovirus E3, CD54:LFA-1, CD55:CD97, CD58:CD2, CD59:CD2, CD100:Plexin-B2, CD120:TNFa/b, CD124:IL-4, and Flk2:Flt3 ligand.

[0013] In other embodiments, the fusion protein comprises a transmembrane domain, a stalk domain, an optional linker (e.g., linker), and a targeting domain. In some embodiments, the fusion protein comprises a viral envelope glycoprotein, an optional linker (e.g., a linker), and a targeting domain. Additional embodiments include fusion proteins comprising the viral transmembrane domain, a stalk domain, an optional linker (e.g., linker), and a targeting domain.

[0014] In some embodiments, one or more domains of a fusion protein comprises a mutation. In some embodiments, the mutation reduces the affinity of an envelope glycoprotein for its target receptor while preserving its fusogenic capabilities. For example, in some embodiments, a transmembrane domain comprises a mutation. In some embodiments, a viral envelope glycoprotein domain comprises a mutation. In other embodiments, a targeting domain comprises a mutation. In other embodiments still, a stalk domain comprises a mutation.

[0015] eVEPs comprising any combination of the fusion proteins disclosed herein are also possible, according to some embodiments. For example, in some embodiments, eVEPs may comprise a first fusion protein comprising a transmembrane domain and a targeting domain and a second fusion protein comprising a viral envelope domain and a targeting domain. The person of ordinary skill in the art will understand that the eVEPs disclosed herein may comprise any suitable number of fusion proteins. Thus, in some embodiments, eVLPs may comprises a first fusion protein, a second fusion protein, a third fusion protein, a fourth fusion protein, a fifth fusion protein, and so on. In some embodiments, the eVLPs comprise at least 2 fusion proteins. [0016] Other aspects of the disclosure relate to eVLP complexes. In some embodiments, the eVLP complexes comprise an eVLP and a small molecule, an antibody, a (poly)nucleic acid, a protein, a peptide, or the like. In some embodiments, the protein or peptide is a recombinant protein or a recombinant peptide. In some embodiments, the eVLP comprises a fusion protein comprising a targeting domain configured to bind to the small molecule, antibody, (poly)nucleic acid, protein, or peptide. In some embodiments, the eVLP comprising the fusion protein comprising the targeting domain binds to the small molecule, an antibody, a (poly)nucleic acid, a protein, a peptide, thus forming an eVLP complex. In some embodiments, the small molecule, antibody, (poly)nucleic acid, protein, or peptide facilitates binding of the eVLP complex to a target cell. In some embodiments, the eVLP complex comprises an antibody bound to thetargeting domain of the fusion protein. In some embodiments, the targeting domain is configured to bind to one or more domains of the antibody. In some embodiments, the antibody facilitates binding of the eVLP to the target cell. In some embodiments, the antibody is any antibody capable of binding to a cell surface (e.g., via a cell surface receptor).

[0017] Any known targeting domain- antibody domain complex known in the art may be used to form the eVLP complexes disclosed herein. For example, in some embodiments, the antibody domain is an IgG antibody, and the targeting domain is a Z-peptide, which is known in the art to bind IgG antibodies. Other antibodies can also be used as described herein (e.g., IgA, IgM, IgE, etc.). Other non-limiting examples are provided in the Detailed Description. Accordingly, in some embodiments, the targeting domain and/or antibody domain may be naturally occurring or non-naturally occurring.

[0018] Any of the eVLP complexes contemplated herein may be formed in vitro or in vivo. For example, in some embodiments, eVLP complexes are formed in vitro by mixing a desired antibody domain (e.g., IgG antibody) with eVLPs comprising fusion proteins comprising targeting domains (e.g., Z-peptide) capable of binding the desired antibody domain. Alternatively, eVLP complexes may be formed in vivo, for example, by administering eVLPs comprising fusion proteins comprising a targeting domain (e.g., Z- peptide) capable of binding to a desired antibody domain to a subject in need thereof, wherein antibody domain is also present within the subject in need. Notably, the subject in need may produce the antibody domain naturally or may be administered the antibody domain prior to or following administration of the eVLPs. [0019] Other aspects of the present disclosure relate to enhancing the selective tropism of eVLPs by chemically conjugating a desired targeting domain to the surface of the eVLP (e.g., using chemical methods as opposed to genetic methods). As such, in some embodiments, the eVLPs disclosed herein comprise at least one conjugation domain capable of forming a bond with a desired targeting domain. In a first set of embodiments, the conjugation domain is a subdomain of a transmembrane domain. In a second set of embodiments, the conjugation domain is a subdomain of a viral envelope glycoprotein domain. In third set of embodiments, the conjugation domain is a subdomain of a stalk domain. In other embodiments, multiple conjugation subdomains are possible within the eVLPs (e.g., the conjugation domain is a subdomain of the transmembrane domain and the envelope glycoprotein domain).

[0020] In some embodiments, the eVLPs comprise one least one conjugation domain comprising at least one reactive group capable of forming a bond with a desired targeting domain comprising a second reactive group (e.g., -COOH + -NH2 or -N3 +-C=C-, etc.) In some embodiments, the reactive group is a chemical group that is naturally occurring in biological systems (e.g., -SH, -NH2, -COOH groups, etc.). In other embodiments, the chemical group is a chemical group that is not naturally occurring in biological systems (e.g., -N3, -C=C-, etc.). For example, in some embodiments, eVLPs comprising a viral envelope protein comprising N-azidoacetylmannosamine (ManNAz) may be reacted with a targeting domain comprising a strained alkyne group (e.g., dibenzocyclooctyne, DIBO). Such embodiments produce eVLPs comprising a viral envelope glycoprotein comprising one or more targeted domains via a 1,2,3-triazole ring linkage.

[0021] Additional aspects of the present disclosure relate to one or more polynucleotides that, collectively, encode for any one of the proteins of the eVLPs disclosed herein. In some embodiments, the one or more polynucleotides comprises a first nucleic acid encoding a first fusion protein. The fusion protein be any fusion protein disclosed herein. For example, in some embodiments the fusion protein comprises a transmembrane domain, a targeting domain, and optionally, a stalk domain. In other embodiments, the one or more polynucleotides further comprises a second nucleic acid sequence encoding a viral envelope glycoprotein. In another embodiment, the one or more polynucleotides further comprise a third nucleic acid sequence encoding a group-specific antigen (gag) protease (pro) polyprotein. In some embodiments, the one or more polynucleotides further comprises a fourth nucleic acid sequence encoding a second fusion protein encoding a base editor, a prime editor, or other protein(e.g., a therapeutic protein). [0022] Other aspects of the present disclosure relate to one or more methods. In some embodiments, the methods relate to methods of producing the eVLPs disclosed herein. For example, in some embodiments, the methods comprise transfecting a cell (e.g., a producer cell) with one or more polynucleotides that encode for said eVLPs. Other methods are directed to methods of editing a nucleic acid molecule in a target cell using any of the eVLPs disclosed herein. In some embodiments, the methods comprise contacting the target cell with any of the eVLPs, polynucleotides, vectors, and/or cells disclosed herein, wherein the eVLPs encapsulate a gene editor (e.g., base editor or prime editor, a therapeutic, etc.), and wherein upon transduction the gene editor installs one or more modifications to the nucleic acid molecule at a target site.

[0023] In other embodiments, the methods comprise methods for treating a disease using the eVLPs disclosed herein. In some embodiments, the methods comprise contacting a target cell (e.g., hematopoietic stem and progenitor cells, HSPCs) with any of the eVLPs, polynucleotides, vectors, and/or cells or compositions thereof disclosed herein, wherein the eVLPs encapsulate a therapeutic (e.g., base editor or prime editor, RNA therapy, peptide therapy, etc.), and wherein upon transduction the gene editor installs one or more modifications to the nucleic acid molecule at a target site, and wherein the one or more modifications are associated with reducing, relieving, treating, curing, or preventing the symptoms of a disease or disorder.

[0024] Other aspects relate to pharmaceutical compositions comprising any of the eVLPs, polynucleotides, vectors, and/or cells disclosed herein, and a pharmaceutical excipient.

[0025] It should be appreciated that the foregoing concepts, and additional concepts discussed below, may be arranged in any suitable combination, as the present disclosure is not limited in this respect. Further, other advantages and novel features of the present disclosure will become apparent from the following detailed description of various nonlimiting embodiments when considered in conjunction with the accompanying Figures.

[0026] International Patent Application Nos. PCT/US2022/080834, PCT/US2022/080836, and PCT/US2022/080856, each of which was filed on December 2, 2022, and each of which is incorporated herein by reference.

BRIEF DESCRIPTION OF THE DRAWINGS

[0027] FIG. 1 shows a schematic drawing of various surface receptors with high- specificity for hematopoietic stem and progenitor cell (e.g., HSPCs) and their cognate ligand including (1) thrombonoietin receptor (e.g., CD110)/Thrombopoietin (TPO), (2) proto- oncogene c-Kit (e.g., c-Kit)/Stem Cell Factor (SCF), C-X-C chemokine receptor type 4 (e.g., CXCR-4)/stromal-derived factor 1 (e.g., CXCL-12 or SDF-1), and CD46 complement regulatory protein (e.g., CD46)/Adenovirus Finger Protein 35 (e.g., AdF35).

[0028] FIG. 2 shows exemplary eVLP constructs comprising (i) a fusion protein comprising a targeting domain and a transmembrane domain, and (ii) a mutated VSVG envelope glycoprotein domain.

[0029] FIG. 3 shows exemplary eVLP constructs comprising (i) a fusion protein comprising a targeting domain and a wild-type VSVG transmembrane domain, and (ii) a mutated VSVG envelope glycoprotein domain.

[0030] FIG. 4 shows exemplary eVLP constructs comprising (i) a fusion protein comprising a targeting domain, a CD8 alpha stalk domain, and a transmembrane domain, and (ii) a mutated VSVG envelope glycoprotein domain.

[0031] FIG. 5 shows exemplary eVLP constructs comprising (i) a fusion protein comprising a targeting domain, an IgG alpha stalk domain, and a transmembrane domain, and (ii) a mutated VSVG envelope glycoprotein domain.

[0032] FIG. 6 shows exemplary eVLP constructs comprising (i) a fusion protein comprising a targeting domain and a transmembrane domain, and (ii) a mutated VSVG envelope glycoprotein domain. The targeting domain is configured to bind to an antibody, which in turn, binds a protein on a target cell.

[0033] FIG. 7 shows an exemplary eVLP comprising a wild-type envelope glycoprotein comprising one or more non-natural moieties.

[0034] FIG. 8 shows a schematic drawing of a version 4 virus-like particle (e.g., v4 eVLP) architecture as published in Banskota, Raguram et al., Cell 185, 250-265 (2022). Vesicular stomatitis virus G protein (e.g., VSVG) is the standard envelope glycoprotein which initiates receptor-mediated endocytosis through the ubiquitously expressed LDL receptor protein (LDLR). The wide expression distribution of LDLR means that v4 eVLPs have the potential to transduce many different cell types, which often results in significant off-target effects.

[0035] FIG. 9 shows exemplary embodiments wherein genome editing agents were selectively delivered to hematopoietic stem cells using eVLPs comprising a targeting protein conjugated to a VSVGmut, a mutated version of the fusogen VSVG (K47Q, R354A) with impaired binding affinity for its natural receptor but with retained fusogenic activity. This fusogen is displayed on v4 eVLP architecture in its binding active form. Here the targeting protein corresponds to a ligand that binds a surface receptor on HSPCs. Exemplary targeting proteins tested include TPO, SCF, CXCL12, and F35.

[0036] FIG. 10 shows a plot of the percentage of reads with the desired A>G edit at position 7 in the BCE11A +58kb enhancer in hCD34+ cells as a function of eVEPs with 50 different targeting architectures. To measure the editing efficiency, eVEPs were engineered to contain an adenine base editor (e.g., ABE8e) and a sgRNA (e.g., A>G edits at position 7 of BCE11A protospacer) as cargo.

[0037] FIG.l 1 shows additional eVEP architectures to display the targeting protein on the eVEP surface, as contemplated herein. As shown in the figure, targeting proteins may be displayed on eVEP surfaces through various transmembrane domains fused to an inert stalk domain which serves as a spacer separating the transmembrane domain from the targeting domain thus allowing access to bind membrane proximal receptors on target cells.

Exemplary inert stalks, as shown, include CD8alpha and IgG.

[0038] FIG. 12A shows the use of wild type (WT) VSVG in a fusion with the targeting proteins (e.g., as opposed to the VSVGmut). Constructs comprising the pCMV-TPO-VSVG and pCMV-SCF-VSVG exhibited 15% and 10% of the editing efficiency of WT VSVG v4 eVLPs in human CD34+ cells, respectively, with no statistically significant loss in cell viability compared to VSVG-eVLPs. Constructs comprising an adenine base editor were validated by observing A>G editing at position 7 of BCL11 A protospacer.

[0039] FIG. 12B shows the viability of CD34+ cells following treatment with targeted- eVLPs as described in FIG. 7.

[0040] FIG. 13A shows an illustration of an exemplary barcoded lentivirus platform for testing viral targeting proteins in a high-throughput, pooled manner. In this screen, HIV 1 lentivirus is produced in an arrayed format (typically 96 w format) by transfecting HEK17 producer cells with pCMV- VSVGmut, psPAX2 (lentiviral packaging plasmid), a barcoded lentiviral genome containing a predefined NNNNNNNNNNNNNNNNNNNN barcode in addition to pCMV-EGFP-P2A-PuroR. FIG. 13B shows an illustration of an exemplary assay used to validate the ability of targets identified from the lentiviral screen to delivery eVEPs to target cells.

[0041] FIG. 14A shows the sequence of exemplary construct pJAQ218 identified during the lentiviral screen. Two barcodes are assigned to each targeting ligand or combination of ligands involved in the screen. FIG. 14B shows the results from an exemplary lentiviral screen using CD34+ cells. The reads assigned to each barcode are plotted in a scatterplot with the hits defined in the upper right quadrant. The soundness of the screen can be ascertained from both the separation of the positive and negative controls (VSV-G and VSV- Gmut here) and the correlation between degenerate barcodes (distinct barcode sequences corresponding to the same targeting ligand). gDNA reads per targeting construct plotted in a scatterplot with the hits defined in the upper right quadrant. .FIGs. 14C and 14D show a plot of the reads assigned to each barcode normalized to the cDNA and gDNA, respectively. FIG. 14D shows a plot of the reads assigned to each barcode normalized to the ratio of the gDNA/cDNA. The color of the dot represents the sum of the cDNA reads between the two barcodes assigned to a single construct. This gives information on production titer achievable for a given construct.

[0042] FIG. 15 shows the results from an exemplary validation study performed using Base-editing eVLPs bearing one or more exemplary candidate targeting proteins identified using the lentiviral screen shown in FIG. 13. BE-eVLPs were screened for their ability to induce an A«T to G*C base edit in the BCL11A gene in CD34+ cells in vitro.

[0043] FIG. 16 shows the results from an exemplary validation study performed using Prime editing eVLPs (PE-eVLPs) bearing pJAQ218, which is a targeting protein identified using the lentiviral screen shown in FIG. 13. eVLP constructs used the V3 and V3b prime editor architectures. PE-eVLPs were screened for their ability to recode a 5bp substitution in the HEK gene in CD34+ cells.

[0044] FIG. 17 shows an exemplary eVLP construct comprising (i) a first fusion protein comprising a first targeting domain, a stalk domain, and a transmembrane domain, (ii) a second fusion protein comprising a second targeting domain, a stalk domain, and a transmembrane domain, and (iii) a mutated Cocal envelope glycoprotein domain. The first targeting domain is different than the second targeting domain.

[0045] FIG.18A shows a scatter plot of the reads assigned to each barcode plotted with the hits defined in the upper right quadrant. The screen was performed using lentiviruses comprisng a mutant cocal glycoenvelope protein. FIG. 18B shows a plot of the reads, normalized to the cDNA, for the data provided in FIG. 18 A.

[0046] FIGs. 19A and 19B shows the results from another exemplary lentiviral screen testing a different array of targeting proteins and VSV-Gmut against CD34+ cells. FIG. 19A shows the reads assigned to each barcode from gDNA; whereas FIG. 19B shows the reads assigned to each barcode from gDNA normalized to the cDNA.

DEFINITIONS [0047] Unless defined otherwise, all technical and scientific terms used herein have the meaning commonly understood by a person skilled in the art to which this invention belongs. The following references provide one of skill with a general definition of many of the terms used in this invention: Singleton et al., Dictionary of Microbiology and Molecular Biology (2nd ed. 1994); The Cambridge Dictionary of Science and Technology (Walker ed., 1988); The Glossary of Genetics, 5th Ed., R. Rieger et al. (eds.), Springer Verlag (1991); and Hale & Marham, The Harper Collins Dictionary of Biology (1991). As used herein, the following terms have the meanings ascribed to them unless specified otherwise.

Base editors

[0048] The term “base editor (BE)” refers to an agent comprising a polypeptide that is capable of making a modification to a base (e.g., A, T, C, G, or U) within a nucleic acid sequence (e.g., DNA or RNA) that converts one base to another (e.g., A to G, A to C, A to T, C to T, C to G, C to A, G to A, G to C, G to T, T to A, T to C, or T to G). In some embodiments, the base editor is capable of deaminating a base within a nucleic acid such as a base within a DNA molecule. In the case of an adenosine base editor, the base editor is capable of deaminating an adenine (A) in DNA. Such base editors may include a nucleic acid programmable DNA binding protein (napDNAbp) fused to an adenosine deaminase. Some base editors include CRISPR-mediated fusion proteins that are utilized in the base editing methods described herein. In some embodiments, the base editor comprises a nucleaseinactive Cas9 (dCas9) fused to a deaminase which binds a nucleic acid in a guide RNA- programmed manner via the formation of an R-loop, but does not cleave the nucleic acid. For example, the dCas9 domain of the fusion protein may include a D10A and a H840A mutations described in PCT/US2016/058344, which published as WO 2017/070632 on April 27, 2017, and is incorporated herein by reference. The DNA cleavage domain of S. pyogenes Cas9 includes two subdomains, the HNH nuclease subdomain and the RuvCl subdomain. The HNH subdomain cleaves the strand complementary to the gRNA (the “targeted strand,” or the strand in which editing or deamination occurs), whereas the RuvCl subdomain cleaves the non-complementary strand containing the PAM sequence (the “non-edited strand”). The RuvCl mutant D10A generates a nick in the targeted strand, while the HNH mutant H840A generates a nick on the non-edited strand (see Jinek et al., Science, 337:816-821(2012); Qi et al., Cell. 28; 152(5): 1173-83 (2013)). In some embodiments, a base editor comprises a Cas9 nickase (nCas9) that comprises only one of the D10A or the H840A mutations. [0049] In some embodiments, a base editor is a macromolecule or macromolecular complex that results primarily (e.g., more than 80%, more than 85%, more than 90%, more than 95%, more than 99%, more than 99.9%, or 100%) in the conversion of a base in a polynucleotide sequence into another base (i.e., a transition or transversion) using a combination of 1) a nucleotide-, nucleoside-, or base-modifying enzyme and 2) a nucleic acid binding protein that can be programmed to bind to a specific nucleic acid sequence.

[0050] In some embodiments, the base editor comprises a DNA binding domain (e.g., a programmable DNA binding domain, such as a dCas9 or nCas9) that directs it to a target sequence. In some embodiments, the base editor comprises a base modification domain fused to a programmable DNA binding domain (e.g., dCas9 or nCas9). The terms “base modifying enzyme” and “base modification domain,” which are used interchangeably herein, refer to an enzyme that can modify a base and convert one base to another (e.g., a deaminase, such as a cytidine deaminase or an adenosine deaminase). The base modifying enzyme of the base editor may target cytosine (C) bases in a nucleic acid sequence and convert the C to a thymine (T) base. In some embodiments, C to T editing is carried out by a deaminase, e.g., a cytidine deaminase. In some embodiments, A to G editing is carried out by a deaminase, e.g., an adenosine deaminase. Base editors that can carry out other types of base conversions (e.g., C to G) are also contemplated.

[0051] In some embodiments, a base editor converts a C to a T. In some embodiments, the base editor comprises a cytosine deaminase. A “cytosine deaminase”, or “cytidine deaminase,” refers to an enzyme that catalyzes the chemical reaction “cytosine + H2O

uracil + NH3” or “5-methyl-cytosine + H2O

thymine + NH3.” As may be apparent from the reaction formula, such chemical reactions result in a C to U/T base change. In the context of a gene, such a nucleotide change, or mutation, may in turn lead to an amino acid change in the protein, which may affect the protein’s function, e.g., loss-of-function or gain-of-function. In some embodiments, the C to T base editor comprises a dCas9 or nCas9 fused to a cytidine deaminase. In some embodiments, the cytidine deaminase domain is fused to the N-terminus of the dCas9 or nCas9. In some embodiments, the base editor further comprises a domain that inhibits uracil glycosylase, and/or a nuclear localization signal. Such base editors have been described in the art, e.g., in Rees & Liu, Nat. Rev. Genet. 2018;19(12):770-788 and Koblan et al., Nat. Biotechnol. 2018;36(9):843-846; as well as U.S. Patent Publication No.

2018/0073012, U.S. Patent Publication No. 2017/0121693, PCT Publication No. WO 2017/070633, U.S. Patent Publication No. 2015/0166980, U.S. Patent No. 9,840,699, U.S. Patent No. 10,077,453, PCT Publication No. WO 2019/023680, PCT Publication No. WO 2018/0176009, PCT Application No PCT/US2019/033848, PCT Application No.

PCT/US2019/47996, PCT Application No. PCT/US2019/049793, PCT Application No. PCT/US2020/028568, PCT Application No. PCT/US2019/61685, PCT Application No. PCT/US2019/57956, and PCT Application No. PCT/US2019/58678, each of which is incorporated herein by reference.

[0052] In some embodiments, a base editor converts an A to a G. In some embodiments, the base editor comprises an adenosine deaminase. An “adenosine deaminase” is an enzyme involved in purine metabolism. An adenosine deaminase catalyzes hydrolytic deamination of adenosine (forming inosine, which base pairs as G) in the context of DNA. There are no known natural adenosine deaminases that act on DNA. Instead, known adenosine deaminase enzymes only act on RNA (tRNA or mRNA). Evolved deoxyadenosine deaminase enzymes that accept DNA substrates and deaminate dA to deoxyinosine have been described, e.g., in PCT Application PCT/US2017/045381, filed August 3, 2017, which published as WO 2018/027078, PCT Application No. PCT/US2019/033848, which published as WO 2019/226953, PCT Application No PCT/US2019/033848, filed May 23, 2019, and PCT Patent Application No. PCT/US2020/028568, filed April 17, 2020; each of which is incorporated herein by reference.

[0053] Exemplary adenosine and cytidine base editors are also described in Rees & Liu, Base editing: precision chemistry on the genome and transcriptome of living cells, Nat. Rev. Genet. 2018;19(12):770-788; as well as U.S. Patent Publication No. 2018/0073012, U.S. Patent Publication No. 2017/0121693, PCT Publication No. WO 2017/070633, U.S. Patent Publication No. 2015/0166980, U.S. Patent No. 9,840,699, and U.S. Patent No. 10,077,453, each of which is incorporated herein by reference.

Cas9

[0054] The term “Cas9” or “Cas9 nuclease” refers to an RNA-guided nuclease comprising a Cas9 domain, or a fragment thereof (e.g., a protein comprising an active or inactive DNA cleavage domain of Cas9, and/or the gRNA binding domain of Cas9). A “Cas9 domain,” as used herein, is a protein fragment comprising an active or inactive cleavage domain of Cas9 and/or the gRNA binding domain of Cas9. A “Cas9 protein” is a full length Cas9 protein. A Cas9 nuclease is also referred to sometimes as a casnl nuclease or a CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat)-associated nuclease. CRISPR is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements, and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems, correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (me), and a Cas9 domain. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently, Cas9/crRNA/tracrRNA endo-nucleolytically cleaves a linear or circular dsDNA target complementary to the spacer. The target strand not complementary to crRNA is first cut endonucleolytically, then trimmed 3'-5' exonucleolytically. In nature, DNA-binding and cleavage typically requires protein and both RNAs. However, single guide RNAs (“sgRNA”, or simply “gRNA”) can be engineered so as to incorporate aspects of both the crRNA and tracrRNA into a single RNA species. See, e.g., Jinek M., Chylinski K., Fonfara I., Hauer M., Doudna J.A., Charpentier E. Science 337:816-821(2012), which is incorporated herein by reference. Cas9 recognizes a short motif in the CRISPR repeat sequences (the PAM or protospacer adjacent motif) to help distinguish self versus non-self. Cas9 nuclease sequences and structures are well known to those of skill in the art (see, e.g., “Complete genome sequence of an Ml strain of Streptococcus pyogenes.” Ferretti et al., J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar E.Z., Ren Q., Zhu H., Song L., White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E., Proc. Natl. Acad. Sci. U.S.A. 98:4658- 4663(2001); “CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III.” Deltcheva E., Chylinski K., Sharma C.M., Gonzales K., Chao Y., Pirzada Z.A., Eckert M.R., Vogel J., Charpentier E., Nature 471:602-607(2011); and “A programmable dual- RNA-guided DNA endonuclease in adaptive bacterial immunity.” Jinek M., Chylinski K., Fonfara I., Hauer M., Doudna J.A., Charpentier E. Science 337:816-821(2012), each of which is incorporated herein by reference). Cas9 orthologs have been described in various species, including, but not limited to, S. pyogenes and 5. thermophilus. Additional suitable Cas9 nucleases and sequences will be apparent to those of skill in the art based on this disclosure, and such Cas9 nucleases and sequences include Cas9 sequences from the organisms and loci disclosed in Chylinski, Rhun, and Charpentier, “The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems” (2013) RNA Biology 10:5, 726-737; which is incorporated herein by reference. In some embodiments, a Cas9 nuclease comprises one or more mutations that partially impair or inactivate the DNA cleavage domain. [0055] A nuclease-inactivated Cas9 domain may interchangeably be referred to as a “dCas9” protein (for nuclease-“dead” Cas9). Methods for generating a Cas9 domain (or a fragment thereof) having an inactive DNA cleavage domain are known (see, e.g., Jinek et al., Science. 337:816-821(2012); Qi et al., “Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression” (2013) Cell. 28; 152(5): 1173-83, the entire contents of each of which are incorporated herein by reference). For example, the DNA cleavage domain of Cas9 is known to include two subdomains, the HNH nuclease subdomain and the RuvCl subdomain. The HNH subdomain cleaves the strand complementary to the gRNA, whereas the RuvCl subdomain cleaves the non-complementary strand. Mutations within these subdomains can silence the nuclease activity of Cas9. For example, the mutations D10A and H840A completely inactivate the nuclease activity of S. pyogenes Cas9 (Jinek et al., Science. 337:816-821(2012); Qi et al., Cell. 28; 152(5): 1173-83 (2013)). In some embodiments, proteins comprising Cas9 or fragments thereof are referred to as “Cas9 variants.” A Cas9 variant shares homology to Cas9, or a fragment thereof. For example, a Cas9 variant is at least about 70% identical, at least about 80% identical, at least about 90% identical, at least about 95% identical, at least about 96% identical, at least about 97% identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, at least about 99.8% identical, at least about 99.9% or 100% identical to a wild type Cas9. In some embodiments, the Cas9 variant may have 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 21, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, or more amino acid changes compared to wild type Cas9. Fusion protein

[0056] The term “fusion protein,” as used herein, refers to a hybrid polypeptide that comprises protein domains from at least two different proteins. One protein may be located at the amino-terminal (N-terminal) portion of the fusion protein or at the carboxy-terminal (C- terminal) protein thus forming an “amino-terminal fusion protein” or a “carboxy-terminal fusion protein,” respectively. A protein may comprise different domains, for example, a nucleic acid binding domain (e.g., the gRNA binding domain of Cas9 that directs the binding of the protein to a target site) and a nucleic acid cleavage domain or a catalytic domain of a nucleic-acid editing protein. Other examples include fusion of a Cas9 or equivalent thereof to a deaminase (as in a base editor) or to a polymerase, such as a reverse transcriptase (as in a prime editor). Any of the fusion proteins provided herein may be produced by any method known in the art. For example, the fusion proteins provided herein may be produced via recombinant protein expression and purification, which is especially suited for fusion proteins comprising a peptide linker. Methods for recombinant protein expression and purification are well known, and include those described by Green and Sambrook, Molecular Cloning: A Laboratory Manual (4th ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (2012)), which is incorporated herein by reference.

Group- specific antigen (gag)

[0057] Without being limited by theory, and in the context of typical envelope virus lifecycle, Gag is the primary structural protein responsible for orchestrating the majority of steps in viral assembly, including budding out of fully-formed enveloped virions having an (i) envelope (comprising a lipid membrane formed from cell membrane during budding out, and one or more glycoproteins inserted therein), and (ii) a capsid, which is the internal protein shell. Most of these assembly steps occur via interactions with three Gag subdomains - matrix (MA), capsid (CA), and nucleocapsid. These three regions have a low level of sequence conservation among the different retroviral genera, which belies the observed high level of structural conservation. Outside of these three domains, Gag proteins can vary widely. For example, HIV-1 Gag additionally codes for a C-terminal p6 protein as well as two spacer proteins, SP1 and SP2, which demarcate the CA-NC and NC-p6 junctions, but HTLV-1 contains no additional sequences outside of MA, CA, and NC (Oroszlan and Copeland, 1985; Henderson et al., 1992).

[0058] Gag is also referred to as a “viral structural protein.” As used herein, the term “viral structural protein” refers to viral proteins that contribute to the overall structure of the capsid protein or of the protein core of a virus. The term “viral structural protein” further includes functional fragments or derivatives of such viral protein contributing to the structure of a capsid protein or of the protein core of a virus. An example of viral structural protein is MMLV Gag. The viral membrane fusion proteins are not considered as viral structural proteins. Typically, said viral structural proteins are localized inside the core of the virus. [0059] In some embodiments, the gag protein used in the eVLPs described herein (including the viral nucleocapsid portion) comprises the sequence of SEQ ID NO: 405, or a sequence at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% identical to the sequence of SEQ ID NO: 405:

[0060] MGQTVTTPLSLTLGHWKDVERIAHNQSVDVKKRRWVTFCSAEWPTFNV GWPRDGTFNRDLITQVKIKVFSPGPHGHPDQVPYIVTWEALAFDPPPWVKPFVHPKP PPPLPPSAPSLPLEPPRSTPPRSSLYPALTPSLGAKPKPQVLSDSGGPLIDLLTEDPPPYR DPRPPPSDRDGNGGEATPAGEAPDPSPMASRLRGRREPPVADSTTSQAFPLRAGGNG QLQYWPFSSSDLYNWKNNNPSFSEDPGKLTALIESVLITHQPTWDDCQQLLGTLLTG EEKQRVEEEARKAVRGDDGRPTQEPNEVDAAFPEERPDWDYTTQAGRNHEVHYRQ EEEAGEQNAGRSPTNEAKVKGITQGPNESPSAFEEREKEAYRRYTPYDPEDPGQETN VSMSFIWQSAPDIGRKEEREEDEKNKTEGDEVREAEKIFNKRETPEEREERIRRETEE KEERRRTEDEQKEKERDRRRHREMSKEEATVVSGQKQDRQGGERRRSQEDRDQCA YCKEKGHWAKDCPKKPRGPRGPRPQTSEETEDD (SEQ ID NO: 405)

Group- specific antigen (gag) nuclcocapsid protein

[0061] The term “group -specific antigen nuclcocapsid protein” or “gag nuclcocapsid protein” refers to a protein that makes up the core structural component of the inner shell of many viruses, including retroviruses. The gag nuclcocapsid proteins used in the VEPs of the present disclosure may be an MMLV gag nuclcocapsid protein, an FMLV gag nuclcocapsid protein, or a nuclcocapsid protein from any other virus that produces such proteins.

Group- specific antigen (gag) protease (pro) polyprotein

[0062] A “group-specific antigen (gag) protease (pro) polyprotein” or “gag-pro polyprotein” refers to a gag nuclcocapsid protein further comprising a viral protease linked thereto. Gag -pro polyproteins mediate proteolytic cleavage of gag and gag-pol polyproteins or nuclcocapsid proteins during or shortly after the release of a virion from the plasma membrane. In the VLPs described herein, the protease of a gag-pro polyprotein is responsible for cleaving a cleavable linker in the fusion protein to release a cargo protein (such as a base editor or prime editor) following delivery of the VLP to a target cell. In some embodiments, a gag-pro polyprotein is an MMLV gag-pro polyprotein or an FMLV gag-pro polyprotein.

Guide RNA (“gRNA”)

[0063] As used herein, the term “guide RNA” is a particular type of guide nucleic acid which is mostly commonly associated with a Cas protein of a CRISPR-Cas9 and which associates with Cas9, directing the Cas9 protein to a specific sequence in a DNA molecule that includes complementarity to the protospacer sequence of the guide RNA. However, this term also embraces the equivalent guide nucleic acid molecules that associate with Cas9 equivalents, homologs, orthologs, or paralogs, whether naturally occurring or non-naturally occurring (e.g., engineered or recombinant), and which otherwise program the Cas9 equivalent to localize to a specific target nucleotide sequence. The Cas9 equivalents may include other napDNAbp from any type of CRISPR system (e.g., type II, V, VI), including Cpfl (a type-V CRISPR-Cas system), C2cl (a type V CRISPR-Cas system), C2c2 (a type VI CRISPR-Cas system), and C2c3 (a type V CRISPR-Cas system). Further Cas-equivalents are described in Makarova et al., “C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector,” Science 2016; 353(6299), which is incorporated herein by reference.

[0064] A guide RNA is a particular type of guide nucleic acid that is most commonly associated with a Cas protein of a CRISPR-Cas9 and which associates with Cas9, directing the Cas9 protein to a specific sequence in a DNA molecule that includes complementarity to the protospacer sequence for the guide RNA. Functionally, guide RNAs associate with Cas9, directing (or programming) the Cas9 protein to a specific sequence in a DNA molecule that includes a sequence complementary to the protospacer sequence for the guide RNA. A gRNA is a component of the CRISPR/Cas system. Typically, a guide RNA comprises a fusion of a CRISPR-targeting RNA (crRNA) and a trans-activation crRNA (tracrRNA), providing both targeting specificity and scaffolding/binding ability for Cas9 nuclease. A “crRNA” is a bacterial RNA that confers target specificity and requires tracrRNA to bind to Cas9. A “tracrRNA” is a bacterial RNA that links the crRNA to the Cas9 nuclease and typically can bind any crRNA. The sequence specificity of a Cas DNA-binding protein is determined by gRNAs, which have nucleotide base-pairing complementarity to target DNA sequences. The native gRNA comprises a 20 nucleotide (nt) Specificity Determining Sequence (SDS), or spacer, which specifies the DNA sequence to be targeted, and is immediately followed by an 80 nt scaffold sequence, which associates the gRNA with Cas9. In some embodiments, the 80nt scaffold sequence comprises any one of the following sequences:

[0065] Sp Flipped:

GTTTAAGAGCTAGAAATAGCAAGTTAAAATAAGGCTAGTCCGTTATCAACTTGA AAAAGTGGCACCGAGTCGGTGC (SEQ ID NO: 388)

[0066] Sp Extended:

GTTTTAGAGCTATGCTGGAAACAGCATAGCAAGTTTAAATAAGGCTAGTCCGTTA TCAACTTGAAAAAGTGGCACCGAGTCGGTGC (SEQ ID NO: 389)

[0067] Sp F&E:

GTTTAAGAGCTATGCTGGAAACAGCATAGCAAGTTTAAATAAGGCTAGTCCGTTA TCAACTTGAAAAAGTGGCACCGAGTCGGTGC (SEQ ID NO: 390) [0068] Sauri 76:

GTTTTAGTACTCTGGAAACAGAATCTACTAAAACAAGGCAAAATGCCGTGTTTAT CTCGTCAACTTGTTGGCGAGA (SEQ ID NO: 391) [0069] Sauri 84:

GTTTTAGTACTCTGTAATGAAAATTACAGAATCTACTAAAACAAGGCAAAATGCC GTGTTTATCTCGTCAACTTGTTGGCGAGA (SEQ ID NO: 392) [0070] eNme2 121: GTTGTAGCTCCCTTTCTCATTTCGGAAACGAAATGAGAACCGTTGCTACAATAAG GCCGTCTGAAAAGATGTGCCGCAACGCTCTGCCCCTTAAAGCTTCTGCTTTAAGG GGCATCGTTTA (SEQ ID NO: 393) [0071] eNme279: GTTGTAGCTCCCGAAACGTTGCTACAATAAGGCCGTCTGAAAAGACGTGCCGCA ACGCTCTGCCTTCTGGCATCGTTTA (SEQ ID NO: 394)

[0072] In some embodiments, the 80 nt scaffold sequence comprises a nucleic acid sequence that is at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5%, at least 99.8%, or 100% identical to any one of the nucleic acid sequences of SEQ ID NO:s: 388-394. [0073] In some embodiments, an SDS spacer of the present disclosure has a length of 15 to 100 nucleotides, or more. For example, an SDS spacer may have a length of 15 to 90, 15 to 85, 15 to 80, 15 to 75, 15 to 70, 15 to 65, 15 to 60, 15 to 55, 15 to 50, 15 to 45, 15 to 40, 15 to 35, 15 to 30, or 15 to 20 nucleotides. In some embodiments, the SDS is 20 nucleotides long. For example, the SDS may be 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 nucleotides long.

At least a portion of the target DNA sequence is complementary to the SDS of the gRNA. For Cas9 to successfully bind to the DNA target sequence, a region of the target sequence is complementary to the SDS of the gRNA sequence and is immediately followed by the correct protospacer adjacent motif (PAM) sequence (e.g., NGG for Cas9 and TTN, TTTN, or YTN for Cpfl). In some embodiments, an SDS is 100% complementary to its target sequence. In some embodiments, the SDS sequence is less than 100% complementary to its target sequence and is, thus, considered to be partially complementary to its target sequence. For example, a targeting sequence may be 99%, 98%, 97%, 96%, 95%, 94%, 93%, 92%, 91%, or 90% complementary to its target sequence. In some embodiments, the SDS of template DNA or target DNA may differ from a complementary region of a gRNA by 1, 2, 3, 4, or 5 nucleotides. [0074] In some embodiments, the guide RNA is about 15-120 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a target sequence. In some embodiments, the guide RNA is 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25,

26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50,

51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75,

76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 97, 98, 99, 100,

101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, or 120 nucleotides long. In some embodiments, the guide RNA comprises a sequence of 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or more contiguous nucleotides that is complementary to a target sequence. Sequence complementarity refers to distinct interactions between adenine and thymine (DNA) or uracil (RNA), and between guanine and cytosine. [0075] As used herein, the terms “prime editing guide RNA” or “PEgRNA” or “extended guide RNA” refer to a specialized form of a guide RNA that has been modified to include one or more additional sequences for implementing the prime editing methods and compositions described herein. As described herein, the prime editing guide RNAs comprise one or more “extended regions” of nucleic acid sequence. The extended regions may comprise, but are not limited to, single- stranded RNA or DNA. Further, the extended regions may occur at the 3' end of a traditional guide RNA. In other arrangements, the extended regions may occur at the 5' end of a traditional guide RNA. In still other arrangements, the extended region may occur at an intramolecular region of the traditional guide RNA, for example, in the gRNA core region which associates and/or binds to the napDNAbp. The extended region comprises a “DNA synthesis template” which encodes (by the polymerase of the prime editor) a single- stranded DNA which, in turn, has been designed to be (a) homologous with the endogenous target DNA to be edited, and (b) which comprises at least one desired nucleotide change (e.g., a transition, a transversion, a deletion, or an insertion) to be introduced or integrated into the endogenous target DNA. The extended region may also comprise other functional sequence elements, such as, but not limited to, a “primer binding site” and a “spacer or linker” sequence, or other structural elements, such as, but not limited to, aptamers, stem loops, hairpins, toe loops (e.g., a 3' toeloop), or an RNA-protein recruitment domain (e.g., MS2 hairpin). As used herein, the “primer binding site” comprises a sequence that hybridizes to a single-strand DNA sequence having a 3 end generated from the nicked DNA of the R-loop. [0076] In certain embodiments, the PEgRNAs have a 5' extension arm, a spacer, and a gRNA core. The 5' extension further comprises in the 5' to 3' direction a reverse transcriptase template, a primer binding site, and a linker. The reverse transcriptase template may also be referred to more broadly as the “DNA synthesis template” where the polymerase of a prime editor described herein is not an RT, but another type of polymerase.

[0077] In certain other embodiments, the PEgRNAs have a 5' extension arm, a spacer, and a gRNA core. The 5' extension further comprises in the 5' to 3' direction a reverse transcriptase template, a primer binding site, and a linker. The reverse transcriptase template may also be referred to more broadly as the “DNA synthesis template” where the polymerase of a prime editor described herein is not an RT, but another type of polymerase.

[0078] In still other embodiments, the PEgRNAs have in the 5' to 3' direction a spacer (1), a gRNA core (2), and an extension arm (3). The extension arm (3) is at the 3' end of the PEgRNA. The extension arm (3) further comprises in the 5' to 3' direction a “primer binding site” (A), an “edit template” (B), and a “homology arm” (C). The extension arm (3) may also comprise an optional modifier region at the 3' and 5' ends, which may be the same sequences or different sequences. In addition, the 3' end of the PEgRNA may comprise a transcriptional terminator sequence. These sequence elements of the PEgRNAs are further described and defined herein.

[0079] In still other embodiments, the PEgRNAs have in the 5' to 3' direction an extension arm (3), a spacer (1), and a gRNA core (2). The extension arm (3) is at the 5' end of the PEgRNA. The extension arm (3) further comprises in the 3' to 5' direction a “primer binding site” (A), an “edit template” (B), and a “homology arm” (C). The extension arm (3) may also comprise an optional modifier region at the 3' and 5' ends, which may be the same sequences or different sequences. The PEgRNAs may also comprise a transcriptional terminator sequence at the 3' end. These sequence elements of the PEgRNAs are further described and defined herein.

Linkers

[0080] The term “linker,” as used herein, refers to a molecule linking two other molecules or moieties. The linker can be an amino acid sequence in the case of a linker joining two fusion proteins. For example, a Cas9 can be fused to a deaminase (e.g., an adenosine deaminase or a cytosine deaminase) by an amino acid linker sequence. A Cas9 can be fused to a reverse transcriptase by an amino acid linker sequence. The linker can also be a nucleotide sequence in the case of joining two nucleotide sequences together (e.g., in a gRNA). In other embodiments, the linker is an organic molecule, group, polymer, or chemical moiety. In some embodiments, the linker is 5-200 amino acids in length, for example, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 30-35, 35-40, 40-45, 45-50, 50-60, 60-70, 70-80, 80-90, 90-100, 100-150, or 150-200 amino acids in length. Longer or shorter linkers are also contemplated.

[0081] The protease cleavage site may be any known in the art, or any sequence yet to be discovered, so long as the corresponding protease may be co-packaged in the VLPs to allow for post-maturation cleavage within the mature VLP particles. Such cleavage sites and their corresponding proteases include but are not limited to: (a) granzyme A, which recognizes and cleaves a sequence comprising ASPRAGGK (SEQ ID NO: 339), (b) granzyme B, which recognizes and cleaves a sequence comprising YEADSLEE (SEQ ID NO: 340), (c) granzyme K, which recognizes and cleaves a sequence comprising YQYRAL (SEQ ID NO: 341), or (d) Cathepsin D, which recognizes and cleaves a sequence comprising LGVLIV (SEQ ID NO: 342). Many other combinations of specific proteases and protease cleavage sites may be used in connection with the present disclosure by co-packing a specific protease during the VLP manufacture process. Such proteases can include, without limitation, Arg-C proteinase, Asp- N Endopeptidase, Caspase 1, Caspase 2, Caspase 3, Caspase 4, Caspase 5, Caspase 7, Caspase 8, Caspase 9, Caspase 10, Chymotrypsin, Clostripain, Enterokinase, Factor Xa, Glutamyl endopeptidase, Granzyme B, Neutrophil elastase, Pepsin, Prolyl-endopeptidase, Proteinase K, Staphylococcal peptidase I, Thermolysin, Thrombin, and Trypsin. Any protease paired with its cognate recognition sequence may be used in the present disclosure proteasesensitive linkers, including any serine protease, cysteine protease, aspartic protease, threonine protease, glutamic protease, metalloprotease, or asparagine peptide lyase (which constitute major classifications of known proteases). The specific protease cleavage sites for said enzymes are well-known in the art and may be utilized in the linkers herein to provide protease-susceptible linkers. napDNAbp

[0082] As used herein, the term “nucleic acid programmable DNA binding protein” or “napDNAbp,” of which Cas9 is an example, refers to a protein that uses RNA:DNA hybridization to target and bind to specific sequences in a DNA molecule. Each napDNAbp is associated with at least one guide nucleic acid (e.g., guide RNA), which localizes the napDNAbp to a DNA sequence that comprises a DNA strand (i.e., a target strand) that is complementary to the guide nucleic acid, or a portion thereof (e.g., the protospacer of a guide RNA). In other words, the guide nucleic-acid “programs” the napDNAbp (e.g., Cas9 or equivalent) to localize and bind to a complementary sequence.

[0083] Without being bound by theory, the binding mechanism of a napDNAbp - guide RNA complex, in general, includes the step of forming an R-loop whereby the napDNAbp induces the unwinding of a double-strand DNA target, thereby separating the strands in the region bound by the napDNAbp. The guide RNA protospacer then hybridizes to the “target strand.” This displaces a “non-target strand” that is complementary to the target strand, which forms the single strand region of the R-loop. In some embodiments, the napDNAbp includes one or more nuclease activities, which then cut the DNA, leaving various types of lesions.

For example, the napDNAbp may comprise a nuclease activity that cuts the non-target strand at a first location, and/or cuts the target strand at a second location. Depending on the nuclease activity, the target DNA can be cut to form a “double- stranded break” whereby both strands are cut. In other embodiments, the target DNA can be cut at only a single site, i.e., the DNA is “nicked” on one strand. Exemplary napDNAbp with different nuclease activities include “Cas9 nickase” (“nCas9”) and a deactivated Cas9 having no nuclease activities (“dead Cas9” or “dCas9”). Exemplary sequences for these and other napDNAbp are provided herein.

Nuclear export sequence (NES)

[0084] The term “nuclear export sequence” or “NES” refers to an amino acid sequence that promotes transport of a protein out of the cell nucleus to the cytoplasm, for example, through the nuclear pore complex by nuclear transport. Nuclear export sequences are known in the art and would be apparent to the skilled artisan. For example, NES sequences are described in Xu, D. et al. Sequence and structural analyses of nuclear export signals in the NESdb database. Mol Biol. Cell. 2012, 23(18) 3677-3693, the contents of which are incorporated herein by reference. Exemplary NES include, but are not limited to, the following:

[0085] MEELSQALASSFSV SEQ ID NO: 406

[0086] PLQLPPLERLTL SEQ ID NO: 407

[0087] NELALKLAGLDI SEQ ID NO: 408

[0088] ERFEMFRELNEALEL SEQ ID NO: 409

[0089] DHAEKVAEKLEALSV SEQ ID NO: 410

[0090] QLVEELLKIICAFQL SEQ ID NO: 411

[0091] TNLEALQKKLEELEL SEQ ID NO: 412 [0092] DVKEEMTSALATMRV SEQ ID NO: 413

[0093] STNGSLAAEFRHLQL SEQ ID NO: 414

[0094] PSVQELTEQIHRLLM SEQ ID NO: 415

[0095] MNFKELKDFLKELNI SEQ ID NO: 416

[0096] ENFEILMKLKESLEL SEQ ID NO: 417

[0097] FETVYELTKMCTIR SEQ ID NO: 418

[0098] SGKASSSLGLQDFDL SEQ ID NO: 419

[0099] PKYSDIDVDGLCSEL SEQ ID NO: 420

[00100] VDLACTPTDVRDVDI SEQ ID NO: 893

[00101] YGEKTTQRDLTELEI SEQ ID NO: 421

[00102] RRIYDITNVLEGIGL SEQ ID NO: 422

[00103] AKIIPYSGLLLVITV SEQ ID NO: 423

[00104] LRSEEVHWLHVDMGV SEQ ID NO: 424

[00105] LQSEEVHWLHLDMGV SEQ ID NO: 425

[00106] LQVRKYSLDLASLIL SEQ ID NO: 426

[00107] AGVEAIIRILQQLLF SEQ ID NO: 427

[00108] TGVEALIRILQQLLF SEQ ID NO: 428

[00109] IVLNQLCVRFFGLDL SEQ ID NO: 429

[00110] SLGGFEITPPVVLRL SEQ ID NO: 430

[00111] EAIQDLCLAVEEVSL SEQ ID NO: 431

[00112] DELLQVLRMMVGVNI SEQ ID NO: 432

[00113] SVMLAVQEGIDLLTF SEQ ID NO: 433

[00114] LSSHFQELSI SEQ ID NO: 434

[00115] QSTHVDIRTLEDLLM SEQ ID NO: 435

[00116] ESSAEDLRTLQQLFL SEQ ID NO: 436

[00117] EFSLPTHHTVRLIRV SEQ ID NO: 437

[00118] MSSGYYLGEILRLAL SEQ ID NO: 438

[00119] DTVLDILRDFFELRL SEQ ID NO: 439

[00120] NSVNEILSEFYYVRL SEQ ID NO: 440

[00121] CAFLSVKKQFEELTL SEQ ID NO: 441

[00122] ISPEHVIQALESLGF SEQ ID NO: 442

[00123] AHWMRQLVSFQKLKL SEQ ID NO: 443

[00124] ATRELDELMASLSDF SEQ ID NO: 444 [00125] YQNIELITFINALKL SEQ ID NO: 445

[00126] FNATAVVRHMRKLQL SEQ ID NO: 446

[00127] SGIFGLVTNLEELEV SEQ ID NO: 447

[00128] EESYTLNSDLARLGV SEQ ID NO: 448

[00129] EESYDLTSHLARLGV SEQ ID NO: 449

[00130] GIQQAHAEQLANMRI SEQ ID NO: 450

[00131] DVKEEMTSALATMRV SEQ ID NO: 451

[00132] AAEPVILDLRDLFQL SEQ ID NO: 452

[00133] MEGCVSNLMV SEQ ID NO: 453

[00134] EGCVSNLMV SEQ ID NO: 454

[00135] DMDFLRNLFSQTLSL SEQ ID NO: 455

[00136] EQLLEIVHDLENLSL SEQ ID NO: 456

[00137] NVMKYFTDLFDYLPL SEQ ID NO: 457

[00138] KVYPIILRLGSNLSL SEQ ID NO: 458

[00139] YAGFSLPHAILRIDL SEQ ID NO: 459

[00140] EIVRDIKEKLCYVAL SEQ ID NO: 460

[00141] EAINKLESNLRELQI SEQ ID NO: 461

[00142] EAINKLENNLRELQI SEQ ID NO: 462

[00143] SDQKQEQLLLKKMYL SEQ ID NO: 463

[00144] KQVLWDRTFSLFQQL SEQ ID NO: 464

[00145] AQLQNLTKRIDSLPL SEQ ID NO: 465

[00146] NDENEHQLSLRTVSL SEQ ID NO: 466

[00147] ISFTEFVKVLEKVDV SEQ ID NO: 467

[00148] MESAITLWQFLLQL SEQ ID NO: 468

[00149] VPKELMQQIENFEKI SEQ ID NO: 469

[00150] QARFILEKIDGKIII SEQ ID NO: 470

[00151] QVKFIKMIIEKELTV SEQ ID NO: 471

[00152] NHRMKNLREISQLGI SEQ ID NO: 472

[00153] NHRVKKLNEISKLGI SEQ ID NO: 473

[00154] TEKHLQKYLRQDLRL SEQ ID NO: 474

[00155] RQERKRPLLDLHIEL SEQ ID NO: 475

[00156] ANMRIQDLKVSLKPL SEQ ID NO: 476

[00157] ATMRVDYEQIKIKKI SEQ ID NO: 477 [00158] LQGEEFVCLKSIILL SEQ ID NO: 478

[00159] THYGQKAILFLPLPV SEQ ID NO: 479

[00160] PSAHEITGLADSLQL SEQ ID NO: 480

[00161] VRLHDVLHSDKKLTL SEQ ID NO: 481

[00162] LINRNGELKLANFGL SEQ ID NO: 482

[00163] LEPLKKLECLKSLDL SEQ ID NO: 483

[00164] The NES examples above are not limiting. The fusion proteins delivered by the presently described VLPs may comprise any known NES sequence, including any of those described in Xu, D. et al. Sequence and structural analyses of nuclear export signals in the NESdb database. Mol. Biol. Cell. 2012, 23(18), 3677-3693; Fung, H. Y. J. et al. Structural determinants of nuclear export signal orientation in binding to exportin CRM1. eLife. 2015, 4:el0034; and Kosugi, S. et al. Nuclear Export Signal Consensus Sequences Defined Using a Localization-based Yeast Selection System. Traffic. 2008, 9(12), 2053-2062, each of which are incorporated herein by reference.

[00165] In various embodiments, the fusion proteins, constructs encoding the fusion proteins, and VLPs disclosed herein further comprise one or more, preferably, at least three nuclear export sequences. In certain embodiments, the fusion proteins comprise at least three NESs. In embodiments with at least three NESs, the NESs can be the same NESs or they can be different NESs. In certain other embodiments, the fusion proteins, constructs encoding the fusion proteins, and VLPs may comprise at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, at least nine, at least ten, or more NESs. In general, the one or more NESs are of sufficient strength to drive accumulation of the VLP proteins (e.g., the Gag-cargo) in a detectable amount respectively in the cytoplasm of a producer cell.

[00166] The location of the NES fusion can be at the N-terminus, the C-terminus, or within a sequence of a fusion protein (e.g., inserted between the encoded napDNAbp component (e.g., Cas9) and the gag nucleocapsid protein). In certain embodiments, the NES (or multiple NESs, e.g., three NESs) are positioned between the napDNAbp and the gag nucleocapsid protein such that they can be cleaved from the napDNAbp upon delivery of the fusion protein to a target cell. NES sequences may preferably be joined to a fusion protein via a cleavable linker, such as protease-cleavable linker (e.g., the Gag-Pro-Pol). In this way, the NES may be removed from the cargo protein after VLP maturation so that the cargo may be free to translocate to the nucleus once delivered to a recipient cell.

[00167] The NESs may be any known NES sequence in the art. The NESs may also be any future-discovered NESs for nuclear export. The NESs also may be any naturally-occurring NES, or any non-naturally occurring NES (e.g., an NES with one or more desired mutations). [00168] The term “nuclear export sequence” or “NES” refers to an amino acid sequence that promotes export of a protein from the cell nucleus, for example, by nuclear transport. Nuclear export sequences are known in the art and would be apparent to the skilled artisan. [00169] In one aspect of the disclosure, a base editor or other fusion protein may be modified with one or more nuclear export sequences (NES), preferably at least three NESs. In certain embodiments, the fusion proteins are modified with two or more, three or more, four or more, five or more, six or more, seven or more, eight or more, nine or more, or ten or more NESs. The disclosure contemplates the use of any nuclear export sequence known in the art at the time of the disclosure, or any nuclear export sequence that is identified or otherwise made available in the state of the art after the time of the instant filing. A representative nuclear export sequence is a peptide sequence that directs the protein out of the nucleus of the cell in which the sequence is expressed. NESs commonly contain hydrophobic amino acid residues in the sequence LXXXLXXLXL, where L is a hydrophobic residue (frequently leucine), and X represents any amino acid. Nuclear export sequences often comprise leucine residues.

[00170] The fusion proteins delivered by the VLPs described herein may also comprise nuclear export sequences that are linked through one or more linkers, e.g., a polymeric, amino acid, nucleic acid, polysaccharide, chemical, or nucleic acid linker element. The linkers within the contemplated scope of the disclosure are not intended to have any limitations and can be any suitable type of molecule (e.g., polymer, amino acid, polysaccharide, nucleic acid, lipid, or any synthetic chemical linker domain) and can be joined to the base editor by any suitable strategy that effectuates forming a bond (e.g., covalent linkage, hydrogen bonding) between the cargo protein and the one or more NESs. In some embodiments, the linker joining one or more NES and a cargo protein is a cleavable linker, as described further herein, such the one or more NES can be cleaved from the cargo protein, e.g., upon delivery of the cargo protein to a target cell.

Nuclear localization sequence (NLS) [00171] The term “nuclear localization sequence” or “NLS” refers to an amino acid sequence that promotes import of a protein into the cell nucleus, for example, by nuclear transport. Nuclear localization sequences are known in the art and would be apparent to the skilled artisan. For example, NLS sequences are described in Plank et al., International PCT Application, PCT/EP2000/011690, filed November 23, 2000, published as WO/2001/038547 on May 31, 2001, the contents of which are incorporated herein by reference for its disclosure of exemplary nuclear localization sequences. In some embodiments, an NLS comprises the amino acid sequence PKKKRKV (SEQ ID NO: 484), MDSLLMNRRKFLYQFKNVRWAKGRRETYLC (SEQ ID NO: 485), KRTADGSEFESPKKKRKV (SEQ ID NO: 486), or KRTADGSEFEPKKKRKV (SEQ ID NO: 487). In other embodiments, NLS comprises the amino acid sequences NLSKRPAAIKKAGQAKKKK (SEQ ID NO: 488), PAAKRVKLD (SEQ ID NO: 489), RQRRNELKRSF (SEQ ID NO: 490), or NQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGY (SEQ ID NO: 491).

[00172] In one aspect of the disclosure, a base editor, prime editor, or other fusion protein may be modified with one or more nuclear localization sequences (NLS), preferably at least two NLSs. In certain embodiments, the fusion proteins are modified with two or more NLSs. The disclosure contemplates the use of any nuclear localization sequence known in the art at the time of the disclosure, or any nuclear localization sequence that is identified or otherwise made available in the state of the art after the time of the instant filing. A representative nuclear localization sequence is a peptide sequence that directs the protein to the nucleus of the cell in which the sequence is expressed. A nuclear localization signal is predominantly basic, can be positioned almost anywhere in a protein’s amino acid sequence, generally comprises a short sequence of four amino acids (Autieri & Agrawal, (1998) J. Biol. Chem. 273: 14731-37, incorporated herein by reference) to eight amino acids, and is typically rich in lysine and arginine residues (Magin et al., (2000) Virology 274: 11-16, incorporated herein by reference). Nuclear localization sequences often comprise proline residues. A variety of nuclear localization sequences have been identified and have been used to effect transport of biological molecules from the cytoplasm to the nucleus of a cell. See, e.g., Tinland et al., (1992) Proc. Natl. Acad. Sci. U.S.A. 89:7442-46; Moede et al., (1999) FEBS Lett. 461:229- 34, which is incorporated herein by reference. Translocation is currently thought to involve nuclear pore proteins. [00173] Most NLSs can be classified in three general groups: (i) a monopartite NLS exemplified by the SV40 large T antigen NLS (PKKKRKV (SEQ ID NO: 484)); (ii) a bipartite motif consisting of two basic domains separated by a variable number of spacer amino acids and exemplified by the Xenopus nucleoplasmin NLS (KRXXXXXXXXXXKKKL (SEQ ID NO: 492)); and (iii) noncanonical sequences such as M9 of the hnRNP Al protein, the influenza virus nucleoprotein NLS, and the yeast Gal4 protein NLS (Dingwall and Laskey 1991).

[00174] Nuclear localization sequences appear at various points in the amino acid sequences of proteins. NLS have been identified at the N-terminus, the C-terminus, and in the central region of proteins. Thus, the disclosure provides fusion proteins that may be modified with one or more NLSs at the C-terminus and/or the N-terminus, as well as at internal regions of the fusion protein. The residues of a longer sequence that do not function as component NLS residues should be selected so as not to interfere, for example, tonically or sterically, with the nuclear localization signal itself. Therefore, although there are no strict limits on the composition of an NLS-comprising sequence, in practice, such a sequence can be functionally limited in length and composition.

[00175] The present disclosure contemplates any suitable means by which to modify a fusion protein to include one or more NLSs. In one aspect, the fusion proteins may be engineered to express a fusion protein that is translationally fused at its N-terminus or its C- terminus (or both) to one or more NLSs, i.e., to form a base editor or prime editor-NLS fusion construct. In other embodiments, a fusion protein-encoding nucleotide sequence may be genetically modified to incorporate a reading frame that encodes one or more NLSs in an internal region of the encoded base editor or prime editor. In addition, the NLSs may include various amino acid linkers or spacer regions encoded between the base editor and the N- terminally, C-terminally, or internally-attached NLS amino acid sequence, e.g., and in the central region of proteins. Thus, the present disclosure also provides for nucleotide constructs, vectors, and host cells for expressing fusion proteins that comprise a base editor or prime editor and one or more NLSs, among other components.

[00176] The fusion proteins delivered by the VLPs described herein may also comprise nuclear localization sequences that are linked to the fusion protein through one or more linkers, e.g., a polymeric, amino acid, nucleic acid, polysaccharide, chemical, or nucleic acid linker element. The linkers within the contemplated scope of the disclosure are not intended to have any limitations and can be any suitable type of molecule (e.g., polymer, amino acid, polysaccharide, nucleic acid, lipid, or any synthetic chemical linker domain) and can be joined to the fusion protein by any suitable strategy that effectuates forming a bond (e.g., covalent linkage, hydrogen bonding) between the fusion protein and the one or more NLSs.

Nucleic acid molecule

[00177] The term “nucleic acid,” as used herein, refers to a polymer of nucleotides. The polymer may include natural nucleosides (i.e., adenosine, thymidine, guanosine, cytidine, uridine, deoxyadenosine, deoxythymidine, deoxyguanosine, and deoxy cytidine), nucleoside analogs (e.g., 2-aminoadenosine, 2-thiothymidine, inosine, pyrrolo-pyrimidine, 3-methyl adenosine, 5-methylcytidine, C5 bromouridine, C5 fluorouridine, C5 iodouridine, C5 propynyl uridine, C5 propynyl cytidine, C5 methylcytidine, 7 deazaadenosine, 7 deazaguanosine, 8 oxoadenosine, 8 oxoguanosine, 0(6) methylguanine, 4-acetylcytidine, 5- (carboxyhydroxymethyl)uridine, dihydrouridine, methylpseudouridine, 1 -methyl adenosine, 1-methyl guanosine, N6-methyl adenosine, and 2-thiocytidine), chemically modified bases, biologically modified bases (e.g., methylated bases), intercalated bases, modified sugars (e.g., 2'-fluororibose, ribose, 2'-deoxyribose, 2'-O-methylcytidine, arabinose, and hexose), or modified phosphate groups (e.g., phosphorothioates and 5' N phosphoramidite linkages).

Nucleocapsid protein

[00178] The term “nucleocapsid protein” refers to a protein that makes up the core structural component of the inner shell of many viruses, including retroviruses. A nucleocapsid protein makes up part of the gag protein. The nucleocapsid proteins used in the VLPs of the present disclosure may be an MMLV gag nucleocapsid protein, an FMLV gag nucleocapsid protein, or a nucleocapsid protein from any other virus that produces such proteins.

Prime editor

[00179] The term “prime editor” refers to fusion constructs comprising a napDNAbp (e.g., Cas9 nickase) and a reverse transcriptase that are capable of carrying out prime editing on a target nucleotide sequence in the presence of a PEgRNA (or “extended guide RNA”). The term “prime editor” may refer to the fusion protein or to the fusion protein complexed with a PEgRNA, and/or further complexed with a second-strand nicking sgRNA. In some embodiments, the prime editor may also refer to the complex comprising a fusion protein (reverse transcriptase fused to a napDNAbp) and a PEgRNA. [00180] Prime editors may be used to carry out prime editing, which is an approach for gene editing using napDNAbps, a polymerase (e.g., a reverse transcriptase), and specialized guide RNAs that include a primer binding site and a DNA synthesis template for encoding desired new genetic information (or deleting genetic information) that is then incorporated into a target DNA sequence. Prime editing is described in Anzalone, A. V. et al., Search- and- replace genome editing without double-strand breaks or donor DNA. Nature 576, 149-157 (2019), which is incorporated herein by reference. See also International PCT Application, PCT/US2020/023721, filed March 19, 2020, and published as WO 2020/191239, which is incorporated herein by reference.

[00181] Prime editing represents a platform for genome editing that is a versatile and precise method to directly write new genetic information into a specified DNA site using a nucleic acid programmable DNA binding protein (“napDNAbp”) working in association with a polymerase (i.e., in the form of a fusion protein or otherwise provided in trans with the napDNAbp), wherein the prime editing system is programmed with a prime editing (PE) guide RNA (“PEgRNA”) that both specifies the target site and templates the synthesis of the desired edit in the form of a replacement DNA strand by way of an extension (either DNA or RNA) engineered onto a guide RNA (e.g., at the 5' or 3' end, or at an internal portion of a guide RNA). The replacement strand containing the desired edit (e.g., a single nucleobase substitution) shares the same sequence as the endogenous strand (or is homologous to it) immediately downstream of the nick site of the target site to be edited (with the exception that it includes the desired edit). Through DNA repair and/or replication machinery, the endogenous strand downstream of the nick site is replaced by the newly synthesized replacement strand containing the desired edit. Cas protein-reverse transcriptase fusions or related systems are used to target a specific DNA sequence with a guide RNA, generate a single strand nick at the target site, and use the nicked DNA as a primer for reverse transcription of an engineered DNA synthesis template that is integrated with the guide RNA. However, while the concept begins with prime editors that use reverse transcriptase as the DNA polymerase component, the prime editors described herein are not limited to reverse transcriptase but may include the use of virtually any DNA polymerase. Indeed, while the application throughout may refer to prime editors with “reverse transcriptase,” it is set forth here that reverse transcriptase are only one type of DNA polymerase that may work with prime editing. Thus, wherever the specification mentions a “reverse transcriptase,” the person having ordinary skill in the art should appreciate that any suitable DNA polymerase may be used in place of the reverse transcriptase. Thus, in one aspect, the prime editors may comprise Cas9 (or an equivalent napDNAbp), which is programmed to target a DNA sequence by associating it with a specialized guide RNA (i.e., PEgRNA) containing a spacer sequence that anneals to a complementary sequence (the complementary sequence to an endogenous protospacer sequence) in the target DNA. The PEgRNA also contains new genetic information in the form of an extension that encodes a replacement strand of DNA containing a desired nucleotide change which is used to replace a corresponding endogenous DNA strand at the target site. To transfer information from the PEgRNA to the target DNA, the mechanism of prime editing involves nicking the target site in one strand of the DNA to expose a 3 '-hydroxyl group. The exposed 3 '-hydroxyl group can then be used to prime the DNA polymerization of the edit-encoding extension on PEgRNA directly into the target site. In various embodiments, the extension — which provides the template for polymerization of the replacement strand containing the edit — can be formed from RNA or DNA. In the case of an RNA extension, the polymerase of the prime editor can be an RNA-dependent DNA polymerase (such as a reverse transcriptase). In the case of a DNA extension, the polymerase of the prime editor may be a DNA-dependent DNA polymerase. The newly synthesized strand (i.e., the replacement DNA strand containing the desired nucleotide edit) that is formed by the prime editor would be homologous to the genomic target sequence (i.e., have the same sequence as), except for the inclusion of one or more desired nucleotide changes (e.g., a single nucleotide substitution, a deletion, or an insertion, or a combination thereof). The newly synthesized (or replacement) strand of DNA may also be referred to as a single strand DNA flap, which would compete for hybridization with the complementary homologous endogenous DNA strand, thereby displacing the corresponding endogenous strand. Resolution of the hybridized intermediate (also referred to as a heteroduplex, comprising the single strand DNA flap synthesized by the reverse transcriptase hybridized to the endogenous DNA strand with the exception of mismatches at positions where desired nucleotide edits are installed in the edit strand) can include removal of the resulting displaced flap of endogenous DNA (e.g., with a 5' end DNA flap endonuclease, FEN1), ligation of the synthesized single strand DNA flap to the target DNA, and assimilation of the desired nucleotide changes as a result of cellular DNA repair and/or replication processes.

Producer cell

[00182] The term “producer cell” refers to any cell type that can be used to make the VLPs described herein. One or more polynucleotides encoding the components of a VLP are transfected, transduced, electroporated, or otherwise inserted into a producer cell. In some embodiments, a single vector comprises polynucleotides encoding all components of the VLP, and in other embodiments, polynucleotides encoding each component of the VLP are split over two, three, or four different vectors. Once the producer cell expresses the polynucleotides, the various components of the VLPs self-assemble spontaneously within the producer cells. Assembly of the VLPs relies on multimerization of the gag polyproteins encoded on the polynucleotides as described above. The gag polyproteins (some of which are fused to a cargo molecule such as a protein) multimerize at the cell membrane of a producer cell and are subsequently released into the producer cell supernatant spontaneously. Producer cell lines include, but are not limited to, Gesicle 293T cells, HEK 293T, 293G, 293SF, 293FT, 293TN, Eent-X 293T, and inducible custom cell lines with lentivirally integrated VEP genes.

Protease cleavage site

[00183] The term “protease cleavage site,” as used herein, refers to an amino acid sequence that is recognized and cleaved by a protease, i.e., an enzyme that catalyzes proteolysis and breaks down proteins into smaller polypeptides, or single amino acids. In some embodiments, a protease cleavage site is included in a cleavable linker in a fusion protein, as described herein. In certain embodiments, a protease cleavage site is cleaved by the protease of a gag-pro polyprotein. In some embodiments, a protease cleavage site comprises an MMLV protease cleavage site or an FMLV protease cleavage site. In certain embodiments, a protease cleavage site comprises one of the amino acid sequences TSTLLMENSS (SEQ ID NO: 334), PRSSLYPALTP (SEQ ID NO: 335), VQALVLTQ (SEQ ID NO: 336), PLQVLTLNIERR (SEQ ID NO: 337), or an amino acid sequence at least 90% identical to any one of SEQ ID NO:s: 1-4. In some embodiments, a protease cleavage site comprises an amino acid sequence of any one of SEQ ID NO:s: 1-8, or an amino acid sequence at least 90% identical to any one of SEQ ID NO:s: 1-8.

Protein, peptide, and polypeptide

[00184] The terms “protein,” “peptide,” and “polypeptide” are used interchangeably herein and refer to a polymer of amino acid residues linked together by peptide (amide) bonds. The terms refer to a protein, peptide, or polypeptide of any size, structure, or function. Typically, a protein, peptide, or polypeptide will be at least three amino acids long. A protein, peptide, or polypeptide may refer to an individual protein or a collection of proteins. One or more of the amino acids in a protein, peptide, or polypeptide may be modified, for example, by the addition of a chemical entity such as a carbohydrate group, a hydroxyl group, a phosphate group, a famesyl group, an isofamesyl group, a fatty acid group, a linker for conjugation, functionalization, or other modification, etc. A protein, peptide, or polypeptide may also be a single molecule or may be a multi-molecular complex. A protein, peptide, or polypeptide may be just a fragment of a naturally occurring protein or peptide. A protein, peptide, or polypeptide may be naturally occurring, recombinant, or synthetic, or any combination thereof. Any of the proteins provided herein may be produced by any method known in the art. For example, the proteins provided herein may be produced via recombinant protein expression and purification, which is especially suited for fusion proteins comprising a peptide linker. Methods for recombinant protein expression and purification are well known, and include those described by Green and Sambrook, Molecular Cloning: A Laboratory Manual (4th ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (2012)), the contents of which are incorporated herein by reference.

Subject

[00185] The term “subject,” as used herein, refers to an individual organism, for example, an individual mammal. In some embodiments, the subject is a human. In some embodiments, the subject is a non-human mammal. In some embodiments, the subject is a non-human primate. In some embodiments, the subject is a rodent. In some embodiments, the subject is a sheep, a goat, a cattle, a cat, or a dog. In some embodiments, the subject is a vertebrate, an amphibian, a reptile, a fish, an insect, a fly, or a nematode. In some embodiments, the subject is a research animal. In some embodiments, the subject is genetically engineered, e.g., a genetically engineered non-human subject. The subject may be of either sex and at any stage of development.

Substitution

[00186] The term “substitution,” as used herein, refers to replacement of a residue within a sequence, e.g., a nucleic acid or amino acid sequence, with another residue, or a deletion or insertion of one or more residues within a sequence. The term “mutation” may also be used throughout the present disclosure to refer to a substitution (i.e., a “nucleic acid mutation” or an “amino acid mutation”). Substitutions are typically described herein by identifying the original residue followed by the position of the residue within the sequence and the identity of the newly mutated/substituted residue. Various methods for making the amino acid substitutions provided herein are well known in the art, and are provided by, for example, Green and Sambrook, Molecular Cloning: A Laboratory Manual (4th ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (2012)). In some embodiments, a substitution is in a viral nucleocapsid protein, which may be part of a VLP as described herein.

Target cell

[00187] A “target cell” refers to any cell type to which a VLP is delivered. In some embodiments, a VLP is used to deliver a particular cargo to a target cell. For example, a VLP may be used to deliver a gene editing agent such as a napDNAbp (e.g., a Cas9 protein), a base editor, or a prime editor to a target cell. Once the VLP enters the target cell, the cargo is released and may perform its function, for example, by editing the genome of the target cell. Target cell types include any cell to which a person of ordinary skill in the art may want to deliver a VLP as described herein. In some embodiments, VLPs are delivered into human embryonic kidney (HEK) cells (e.g., HEK 293 or HEK 293T cells). In some embodiments, VLPs are delivered into stem cells (e.g., human stem cells) such as, for example, pluripotent stem cells (e.g., human pluripotent stem cells including human induced pluripotent stem cells (hiPSCs)).

[00188] Target cell types contemplated by the present disclosure include, but are not limited to, stem and progenitor cells (e.g., embryonic stem cells, hematopoietic stem cells, mesenchymal stem cells, neural crest cells, etc.), endothelial cells, muscle cells, myocardial cells, smooth and skeletal muscle cells, mesenchymal cells, epithelial cells, hematopoietic cells, lymphocytes such as T-cells (e.g., Thl T cells, Th2 T cells, ThO T cells, cytotoxic T cells) and B cells (e.g., pre-B cells), monocytes, dendritic cells, neutrophils, macrophages, natural killer cells, mast cells, adipocytes, immune cells, neurons, hepatocytes, and cells involved with particular organs (e.g., thymus, endocrine glands, pancreas, brain, neurons, glia, astrocytes, dendrocytes, osteoblasts, osteoclasts, gametes, fat cells, and genetically modified cells thereof).

[00189] In some embodiments, VLPs are delivered into a cell line, such as, but not limited to, 293-T, 3T3, 4T1, 721, 9L, A-549, A172, A20, A253, A2780, A2780ADR, A2780cis, A431, ALC, B16, B35, BCP-1, BEAS-2B, bEnd.3, BHK-21, BR 293, BxPC3, C2C12, C3H- 10T1/2, C6, C6/36, Cal-27, CGR8, CHO, CML Tl, CMT, COR-L23, COR-L23/5010, COR- L23/CPR, COR-L23/R23, COS-7, COV-434, CT26, D17, DH82, DU145, DuCaP, E14Tg2a, EL4, EM2, EM3, EMT6/AR1, EMT6/AR10.0, FM3, H1299, H69, HB54, HB55, HCA2, Hepalclc7, High Five cells, HL-60, HMEC, HT-29, HUVEC, J558L cells, Jurkat, JY cells, K562 cells, KCL22, KG1, Ku812, KY01, LNCap, Ma-Mel 1, 2, 3....48, MC-38, MCF-10A, MCF-7, MDA-MB-231, MDA-MB-435, MDA-MB-468, MDCK II, MG63, MONO-MAC 6, MOR/0.2R, MRC5, MTD-1A, MyEnd, NAEM-1, NCI-H69/CPR, NCI-H69/LX10, NCI- H69/LX20, NCI-H69/LX4, NIH-3T3, NW- 145, OPCN/OPCT Peer, PNT-1A/PNT 2, PTK2, Raji, RBL cells, RenCa, RIN-5F, RMA/RMAS, S2, Saos-2 cells, Sf21, Sf9, SiHa, SKBR3, SKOV-3, T-47D, T2, T84, THP1, U373, U87, U937, VCaP, WM39, WT-49, X63, YAC-1, or YAR cells.

Treatment

[00190] The terms “treatment,” “treat,” and “treating,” refer to a clinical intervention aimed to reverse, alleviate, delay the onset of, or inhibit the progress of a disease or disorder, or one or more symptoms thereof, as described herein. As used herein, the terms “treatment,” “treat,” and “treating” refer to a clinical intervention aimed to reverse, alleviate, delay the onset of, or inhibit the progress of a disease or disorder, or one or more symptoms thereof, as described herein. In some embodiments, treatment may be administered after one or more symptoms have developed and/or after a disease has been diagnosed. In other embodiments, treatment may be administered in the absence of symptoms, e.g., to prevent or delay onset of a symptom or inhibit onset or progression of a disease. For example, treatment may be administered to a susceptible individual prior to the onset of symptoms (e.g., in light of a history of symptoms and/or in light of genetic or other susceptibility factors). Treatment may also be continued after symptoms have resolved, for example, to prevent or delay their recurrence.

Variant

[00191] As used herein, the term “variant” should be taken to mean the exhibition of qualities that have a pattern that deviates from what occurs in nature, e.g., a variant nucleocapsid protein is a nucleocapsid protein comprising one or more changes in amino acid residues as compared to a wild type nucleocapsid protein amino acid sequence. The term “variant” encompasses homologous proteins having at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, at least 99% or 100% identity with a reference sequence and having the same or substantially the same functional activity or activities as the reference sequence. The term also encompasses mutants, truncations, or domains of a reference sequence that display the same or substantially the same functional activity or activities as the reference sequence.

Vector [00192] The term “vector,” as used herein, refers to a nucleic acid that can be modified to encode a gene of interest and that is able to enter a host cell and replicate within the host cell, and then transfer a replicated form of the vector into another host cell. Exemplary suitable vectors include viral vectors, such as retroviral vectors or bacteriophages and filamentous phage, and conjugative plasmids. Additional suitable vectors will be apparent to those of skill in the art based on the instant disclosure.

Viral envelope glycoprotein

[00193] The term “viral envelope glycoprotein” refers to oligo saccharide-containing proteins that form a part of the viral envelope, i.e., the outermost layer of many types of viruses that protects the viral genetic materials when traveling between host cells. Glycoproteins may assist with identification and binding to receptors on a target cell membrane so that the viral envelope fuses with the membrane, allowing the contents of the viral particle (which may be, e.g., a VLP as described herein) to enter the host cell. This property may also be referred to as “tropism.” The viral envelope glycoproteins used in the VLPs of the present disclosure may comprise any glycoprotein from an enveloped virus. In some embodiments, a viral envelope glycoprotein is an adenoviral envelope glycoprotein, an adeno-associated viral envelope glycoprotein, a retroviral envelope glycoprotein, or a lentiviral envelope glycoprotein. In certain embodiments, a viral envelope glycoprotein is a vesicular stomatitis virus G protein (VSVG), a baboon retroviral envelope glycoprotein (BaEVRless), a FuG-B2 envelope glycoprotein, an HIV-1 envelope glycoprotein, or an ecotropic murine leukemia virus (MLV) envelope glycoprotein, or a mutant form thereof.

Virus-like particles (VLPs)

[00194] As used herein, a “virus-like particle (VLP)” (or “engineered virus-like particle (eVLP),” which is used interchangeably with the term “VLP” herein) consists of a supra- molecular assembly comprising (a) an envelope comprising (i) a lipid membrane (e.g., singlelayer or bi-layer membrane) and a (ii) viral envelope glycoprotein, and (b) a multi-protein core region comprising (ii) a Gag protein, (ii) a first fusion protein comprising a Gag protein and Pro-Pol, and (iii) a second fusion protein comprising a Gag protein fused to a cargo protein via a protease-cleavable linker. In some embodiments, the gag protein comprises a nucleocapsid protein variant as described herein. In various embodiments, the cargo protein is a napDNAbp (e.g., Cas9). In other embodiments, the cargo protein is a base editor. In other embodiments, the cargo protein is a prime editor. In various other embodiments, the multiprotein core region of the VLPs further comprises one or more guide RNA molecules which are complexed with a napDNAbp, base editor, or prime editor to form a ribonucleoprotein (RNP). In some embodiments, the guide RNA molecule comprises a barcode sequence as described herein (e.g., a barcode sequence associated with a nucleocapsid protein variant that forms part of the gag protein). In various embodiments, the VLPs are prepared in a producer cell that is transiently transformed with plasmid DNA that encodes that various protein and nucleic acid (sgRNA) components of the VLPs. The components self-assemble at the cell membrane and bud out in accordance with the naturally occurring mechanism of retroviral budding in order to release from the cell fully-matured VLPs. Once formed, the Pol-Pro cleaves the protease- sensitive linker joining the Gag-cargo linker (e.g., the linker joining a Gag to a napDNAbp RNP) to release the cargo within the VLP. Once the VLP is administered to a recipient target cell and taken up by said target cell, the contents of the VLP are released, including free cargo (e.g., a napDNAbp, base editor, or prime editor). Once in the cell, the cargo may translocate to the nuclease of the cell (in particular, where NLSs are included on an RNP cargo), where DNA editing may occur at target sites specified by the guide RNA.

[00195] In some embodiments, the protease-cleavable linker is optimized to improve cleavage efficiency after VLP maturation. In some embodiments, the Gag-cargo fusion (e.g., Gag::BE) further comprises one or more nuclear export signals at one or more locations along the length of the fusion polypeptide protein which may be joined by a cleavable linker such that during VLP assembly in the producer cell, the Gag-cargo fusions (due to presence of competing NLS signals) do not accumulate in the nucleus of the producer cells but instead are available in the cytoplasm to undergo the VLP assembly process at the cell membrane. Once inside the matured VLPs following release from the producer cell, the NES may be cleaved by Pro-Pol, thereby separating the cargo (e.g., napDNAbp, base editor, or prime editor) from the NES. Upon delivery to a recipient cell, therefore, the cargo (e.g., napDNAbp, base editor, or prime editor, typically flanked with one or more NLS elements) will not comprise an NES element, which may otherwise prohibit the transport of the cargo into the nucleus and hinder gene editing activity.

[00196] In some embodiments, an optimized stoichiometry ratio of Gag-cargo fusion to Gag-Pro-Pol fusion protein is used, which balances the amount of Gag-cargo available to be packaged into VLPs with the amount of retrovirus protease (the “Pro” in the Gag-Pro-Pol fusion) required for VLP maturation. In some embodiments, the optimized ratio of Gag-cargo fusion to Gag-Pro-Pol fusion protein is achieved by the appropriate ratio of plasmids encoding each component which are transiently delivered to the producer cells. In some embodiments, the optimal gag-cargo:gag-pro-pol stoichiometry is 25% gag-cargo:75% gag- pro-pol.

[00197] In some embodiments, a VLP comprises additional agents for targeting the VLP for delivery to particular cell types. For example, such additional targeting agents may be incorporated into the outer lipid membrane encapsulation layer of the VLP. In some embodiments, the additional targeting agent is a protein. In certain embodiments, the additional targeting agent is an antibody.

[00198] Thus, as used herein, a virus-derived particle comprises a virus-like particle formed by one or more virus-derived protein(s), which virus-derived particle is substantially devoid of a viral genome such that the VLP is replication-incompetent when delivered to a recipient cell.

Wild type

[00199] As used herein the term “wild type” is a term of the art understood by skilled persons and means the typical form of an organism, strain, gene or characteristic as it occurs in nature as distinguished from mutant or variant forms.

Click Chemistry

[0105] The term “click chemistry” refers to a chemical synthesis technique introduced by K. Barry Sharpless of The Scripps Research Institute, describing chemistry tailored to generate covalent bonds quickly and reliably by joining small units comprising reactive groups together. See, e.g., Kolb, Finn and Sharpless Angewandte Chemie International Edition (2001) 40: 2004-2021; Evans, Australian Journal of Chemistry (2007) 60: 384-395).

Exemplary coupling reactions (some of which may be classified as “click chemistry”) include, but are not limited to, formation of esters, thioesters, amides (e.g., such as peptide coupling) from activated acids or acyl halides; nucleophilic displacement reactions (e.g., such as nucleophilic displacement of a halide or ring opening of strained ring systems); azidealkyne Huisgen cycloaddition; thiol-yne addition; imine formation; Michael additions (e.g., maleimide addition); and Diels- Alder reactions (e.g., tetrazine [4 + 2] cycloaddition).

Exemplary click chemistry reactions include, but are not limited to, azide-alkyne Huisgen cycloaddition; and Diels-Alder reactions (e.g., tetrazine [4 + 2] cycloaddition). In some embodiments, click chemistry reactions are modular, wide in scope, give high chemical yields, generate inoffensive byproducts, are stereospecific, exhibit a large thermodynamic driving force > 84 kJ/mol to favor a reaction with a single reaction product, and/or can be carried out under physiological conditions. In some embodiments, a click chemistry reaction exhibits high atom economy, can be carried out under simple reaction conditions, use readily available starting materials and reagents, uses no toxic solvents or use a solvent that is benign or easily removed (preferably water), and/or provides simple product isolation by non- chromatographic methods (crystallization or distillation).

[0106] The term “click chemistry handle,” as used herein, refers to a reactant, or a reactive group, that can partake in a click chemistry reaction. For example, a strained alkyne, e.g., a cyclooctyne, is a click chemistry handle, since it can partake in a strain-promoted cycloaddition (see, e.g., Table 1). In general, click chemistry reactions require at least two molecules comprising click chemistry handles that can react with each other. Such click chemistry handle pairs that are reactive with each other are sometimes referred to herein as partner click chemistry handles. For example, an azide is a partner click chemistry handle to a cyclooctyne or any other alkyne. Exemplary click chemistry handles suitable for use according to some aspects of this invention are described herein, for example, in Tables 1 and 2. In some embodiments, click chemistry handles are used that can react to form covalent bonds in the presence of a metal catalyst, e.g., copper (II). In some embodiments, click chemistry handles are used that can react to form covalent bonds in the absence of a metal catalyst. Additional suitable click chemistry handles are well known to those of skill in the art, and such click chemistry handles include, but are not limited to, the click chemistry reaction partners, groups, and handles described in Becer, Hoogenboom, and Schubert, Click Chemistry beyond Metal-Catalyzed Cycloaddition, Angewandte Chemie International Edition (2009) 48: 4900 - 4908 and PCT/US2012/044584 and references therein, which references are incorporated herein by reference for click chemistry handles and methodology.

Table 1: Exemplary click chemistry handles and reactions.

Table 2: Exemplary click chemistry handles and reactions (from Becer, Hoogenboom, and

Schubert, Click Chemistry Beyond Metal-Catalyzed Cycloaddition, Angewandte Chemie

International Edition (2009) 48: 4900 - 4908.).

DETAILED DESCRIPTION [00200] The present disclosure provides articles and methods for the selective transduction and genome editing of human cells (e.g., hematopoietic stem and progenitors cells, HSPCs) using engineered viral like particles (e.g., eVLPs). Aspects of the disclosure provide eVLPs comprising fusion proteins comprising a targeting moiety. In some embodiments, the fusion proteins comprise a cytokine conjugated to a transmembrane protein and/or an envelope glycoprotein. In other embodiments, the fusion proteins comprise a targeting moiety domain, a stalk protein domain, a transmembrane domain and/or envelope glycoprotein domain. Targeted-eVLP architectures comprising fusion proteins comprising various targeting domains, stalk domains, transmembrane domains, and envelope glycoproteins are also provided herein. In some embodiments, the eVLP comprise a second fusion protein comprising various targeting domains, stalk domains, and transmembrane domains or envelope glycoprotein domain. In some embodiments, the first fusion protein and second fusion protein comprise the same targeting domains, stalk domains, and transmembrane or envelope glycoprotein domains. In some embodiments, the first fusion protein and second fusion protein comprise different targeting domains, stalk domains, and transmembrane or envelope glycoprotein domains. In some embodiments, the different targeting domains are configured to bind the same, or different, target (e.g., receptor) on a target cell (e.g., they both target the same cell type, such as HSPC or immune cells).

[00201] Other aspects of the disclosure provide eVLP compositions comprising envelope glycoproteins comprising non-natural sugars and methods of conjugating various targeting moieties to said eVLPs using bio-orthogonal click chemistry. Polynucleotides, vectors, cells, and kits useful for producing the articles, and performing the methods, described herein are also provided.

[00202] As described elsewhere herein, current eVLP architectures (e.g., v4 eVLPs) use VSVG as the standard envelope glycoprotein. VSVG initiates receptor- mediated endocytosis through the ubiquitously expressed LDL receptor protein (LDLR). The wide expression distribution of LDLR means that v4 eVLPs have the potential to transduce many cell types. While this has obvious benefits especially in an ex vivo context, this property increases transduction in off-target cell types, especially in the liver. Therefore, the effective dose reaching the target cell population for a given disease is much lower than the administered dose since off-target cells act as a sink for the high-activity eVLPs.

[00203] The inventors of the present disclosure have now discovered that eVLP architectures comprising a targeting domain increases the effective dose of a therapeutic (e.g., genome editors) reaching a target cell. For example, eVLPs carrying genome editors permit delivery of gene editors to correct disease-associated alleles only in the cell types where they exert the most substantial phenotypic effect. Importantly, the inventors have surprisingly shown that non- viral targeting domains (e.g., cytokines) may be incorporated into eVLP architectures thus greatly enhancing the specificity of transduction both in vitro and in vivo. As such, aspects of the present disclosure are generally directed toward compositions of eVLPs comprising one or more targeting domains and methods of making the same, both in vitro and in vivo. The following is a description of various elements that permit the targeted delivery of eVLPs as contemplated herein. eVLP Constructs

[00204] The core components used to assemble the eVLPs of the present disclosure are discussed elsewhere herein, but in general include one or more retrovirus-derived structural protein(s) and optionally one or more virus-derived envelope protein(s) or mutated variants thereof. FIG. 2 shows an exemplary embodiment of an eVLP comprising a fusion protein comprising a transmembrane (TM) domain, a targeting domain, and a linker. FIG 2 also shows other eVLP components including the (i) lipid membrane e.g., single-layer or bi-layer membrane), a mutant viral envelope glycoprotein (e.g., VSVG-mut) and a multi-protein core region enclosed by the envelope and comprising a Gag protein, a Gag-Pro-Pol protein, and a Gag-cargo fusion protein. Thus, in some embodiments, the fusion protein is conjugated to a transmembrane domain, and the envelope glycoprotein is a mutant envelope glycoprotein (e.g., VSVG-mutant, Cocal-mutant, Nipah virus mutant). Such embodiments may be useful, for example, for ablating the native cellular tropism associated with the VSVG glycoprotein while retaining fusogenic activity and enhancing selective tropism toward a specific cell type. Other envelope glycoproteins and/or mutant envelope glycoproteins are also contemplated. For example, in some embodiments, the envelope glycoprotein is derived from the vesicular stomatitis virus G (e.g., VSVG), the Cocal, virus and/or Nipah virus. In some embodiments, the mutant envelope protein comprises an envelope glycoprotein derived from the vesicular stomatitis virus (e.g., VSVG), Cocal virus, and/or Nipah virus. The fusion protein may comprise other domains (e.g., stalk domain) and/or combinations of domains (e.g., targeting domains) according to other embodiments.

[00205] FIG. 3 shows an exemplary embodiment of an eVLP comprising a fusion protein comprising a wild type envelope glycoprotein domain, a targeting domain, and a linker. The eVLP construct in FIG. 3 also comprises a mutant envelope glycoprotein, e.g., VSVG-mutant that possesses impaired binding affinity to the LDLR but retains its fusogenic activity. Such embodiments may be useful, for example, for increasing the transduction efficiency of the eVLPs into in a target cell type. The fusion protein may comprise other domains (e.g., stalk domain) and/or combinations of domains (e.g., targeting domains) according to other embodiments.

[00206] FIGs. 4 and 5 show exemplary embodiments of an eVLP comprising a fusion protein comprising a transmembrane (TM) domain, a stalk domain, and a targeting domain. Again, the eVLP construct in FIGs. 4 and 5 also comprises a mutant envelope glycoprotein, e.g., VSVG-mutant that possesses impaired binding affinity to the LDLR but retains its fusogenic activity. In some embodiments, the stalk domains are inert and serve as linkers (or spacers) to separate the transmembrane domain, which incorporates into the eVLP capsid, from the targeting protein. In some embodiments, the stalk domain comprises CD8-alpha or a fragment thereof (e.g., FIG. 4). In other embodiments, the stalk domain comprises IgG, or a fragment thereof (e.g., FIG. 5). Again, such embodiments, are useful for increasing the transduction efficiency of the eVLPs. The fusion protein may comprise other domains and/or combinations of domains (e.g., targeting domains) according to other embodiments.

[00207] FIG. 6 shows an exemplary embodiment of an eVLP comprising a fusion protein comprising a transmembrane (TM) domain, a targeting domain, and a linker. In this set of embodiments, however, the targeting domain binds to a second targeting domain, which in turn binds to a target receptor on a target cell (e.g., HSBC cell). For example, in certain embodiments, the targeting domain comprises an IgG binding peptide configured to bind to an IgG antibody (e.g., an anti-CDl 10 IgG antibody). Such embodiments are useful, for example, to enhance the targeting specificity of the eVLP construct. The fusion protein may comprise other domains (e.g., stalk domain) and/or combinations of domains (e.g., targeting domains) according to other embodiments.

[00208] FIG. 7 shows an exemplary eVLP comprising a non-natural moiety (e.g., an azido (-N3) functionality) and an exemplary method of producing the same. It will be appreciated that general methods are known in the art for incorporating non-natural moieties (e.g., N-(4- pentynoyl mannosamine, N-azidoacetylmannosamine, etc.) into cell surface glycoproteins (e.g., such as VSVG). Thus, in some embodiments, eVLPs of the present disclosure comprise an envelope glycoprotein with one or more azido functionalities. In other embodiments, the eVLPs comprises an envelope glycoprotein with one or more alkyne or strained alkyne functionalities. [00209] FIG. 17 shows an exemplary embodiment of an eVLP comprising a fusion protein comprising a transmembrane (TM) domain (e.g., ICAM1), a stalk domain (e.g., CD8a), and two different targeting domains (e.g., a-CD4 scFV and a-CD8 scFV). The eVLP construct comprises a mutant envelope glycoprotein, e.g., Cocal mut that possesses impaired binding affinity that reduces its broad tropism but retains its fusogenic activity. In some embodiments, the stalk domains are inert and serve as linkers (or spacers) to separate the transmembrane domain, which incorporates into the eVLP capsid, from the targeting protein. In some embodiments, the stalk domain is CD8-alpha. In other embodiments, the stalk domain is IgG. Again, such embodiments, are useful for increasing the transduction efficiency of the eVLPs. The fusion protein may comprise other domains and/or combinations of domains (e.g., targeting domains) according to other embodiments.

[00210] In some embodiments, a virus-like particle comprises a fusion protein comprising a transmembrane domain, a stalk domain, and a targeting domain, wherein the targeting domain is not a viral envelope glycoprotein, an antibody, or an antibody fragment.

[00211] In some embodiments, a virus-like particle comprises a fusion protein comprising a transmembrane domain, a stalk domain, and two or more targeting domains, wherein the targeting domains are not a viral envelope glycoprotein, an antibody, or an antibody fragment.

[00212]

[00213] In some embodiments, a virus-like particle comprises a fusion protein comprising a transmembrane domain and a targeting domain, wherein the targeting domain is not a viral envelope glycoprotein, an antibody, or an antibody fragment.

[00214] In some embodiments, a virus-like particle comprises (a) a fusion protein comprising (i) a transmembrane domain and (ii) a targeting domain, and (b) an antibody domain, wherein the targeting domain of the fusion protein binds to the antibody domain to form a virus-like particle-antibody complex, and wherein, the targeting domain is not an envelope glycoprotein, an antibody, or a fragment of an antibody.

[00215] In some embodiments, a virus-like particle comprises (a) a fusion protein comprising (i) a transmembrane domain, (ii) a stalk domain, and (iii) a targeting domain, and (b) an antibody domain, wherein the targeting domain of the fusion protein binds to the antibody domain to form a virus-like particle-antibody complex, and wherein, the targeting domain is not an envelope glycoprotein, an antibody, or a fragment of an antibody. [00216] In some embodiments, the virus-like particle comprises at least one conjugation domain.

Fusion proteins

[00217] One strategy, contemplated herein, for enhancing the selective tropism of eVLPs is to genetically engineer the eVLP to display a targeting domain on the surface of the viral capsid. As such, in some embodiments, eVLPs of the present disclosure comprise a fusion protein comprising a targeting domain. In some embodiments, the fusion protein comprises a transmembrane domain and a targeting domain. In some embodiments, the eVLP comprises a fusion protein comprising a transmembrane domain, a stalk domain, and a targeting domain. Additionally, the fusion protein may further, optionally comprise one or more linkers (e.g., linkers), for example, between the transmembrane domain and the targeting domain, between the transmembrane domain and the stalk domain, between the stalk domain and the targeting domain, and/or between the targeting domain and a signaling peptide. In some embodiments, the one or more linkers is a first linker, a second linker, a third linker, and so on. In some embodiments, the one or more linkers may be used to link any two domains. For example, in some embodiments, an optional first linker (e.g., flexible) connects the transmembrane domain and the targeting domain and an optional second linker (e.g., flexible) connects the stalk domain to targeting domain. Other compositions are also possible in other embodiments, for example, a fusion protein may comprise a targeting domain and an envelope glycoprotein domain (e.g., VSVG). In some embodiments, an eVLP may comprise more than one fusion protein comprising any one of the domains described above. In some embodiments, the domains of the more than one fusion proteins are the same; in other embodiments, the domains of the more than one fusion proteins are different. For example, in some embodiments, an eVLP comprises a first fusion protein comprising an ICAM1 transmembrane domain, a CD8a stalk domain, and a aCD4 scFv targeting domain and a second fusion protein comprising comprising an ICAM1 transmembrane domain, a CD8a stalk domain, and a aCD8-scFv targeting domain (FIG. 17). In some embodiments, the eVLP targets HSC cells. In other embodiments, the eVLPs target immune cells, such as CD4+ or CD8+ T cells. The fusion protein may have any suitable structure and/or orientation known in the art. For example, in some embodiments, the fusion proteins comprise the following structures:

[00218] N-terminus- [Transmembrane domain or envelope glycoprotein domain]- [Targeting domain] -[optional signal peptide] -C-terminus. [00219] C-terminus-[Transmembrane domain or envelope glycoprotein domain]- [Targeting domain] -[optional signal peptide]-N-terminus.

[00220] N-terminus- [Transmembrane domain or envelope glycoprotein domain] -[optional linker] -[Targeting domain] -[optional signal peptide] -C-terminus.

[00221] C-terminus-[Transmembrane domain or envelope glycoprotein domain] -[optional linker] -[Targeting domain] -[optional signal peptide]-N-terminus.

[00222] N-terminus- [Transmembrane domain or envelope glycoprotein domain] -[Stalk domain] -[Targeting domain] -[optional signal peptide] -C-terminus.

[00223] C-terminus-[Transmembrane domain or envelope glycoprotein domain] -[Stalk domain] -[Targeting domain] -[optional signal peptide]-N-terminus.

[00224] N-terminus- [Transmembrane domain or envelope glycoprotein domain] -[optional linker] -[Stalk domain] -[Targeting domain]-[ optional signal peptide] -C-terminus.

[00225] C-terminus-[Transmembrane domain or envelope glycoprotein domain] -[optional linker] -[Stalk domain] -[Targeting domain]- [optional signal peptide] -N-terminus.

[00226] N-terminus- [Transmembrane domain or envelope glycoprotein domain] -[Stalk domain] -[optional linker] -[Targeting domain]- [optional signal peptide] -C-terminus.

[00227] C-terminus-[Transmembrane domain or envelope glycoprotein domain] -[Stalk domain] -[optional linker] -[Targeting domain] -[optional signal peptide]-N-terminus.

[00228] N-terminus- [Transmembrane domain or envelope glycoprotein domain] -[optional linker] -[Stalk domain] -[optional linker] -[Targeting domain] -[optional signal peptide] -C- terminus.

[00229] C-terminus-[Transmembrane domain or envelope glycoprotein domain] -[optional linker] -[Stalk domain] -[optional linker] -[Targeting domain] -[optional signal peptide]-N- terminus.

Transmembrane domain

[00230] In some embodiments, the eVLPs comprise a fusion protein comprising a transmembrane domain. Any suitable transmembrane domain known to one of ordinary skill in the art may be used to make the fusion proteins contemplated herein. In some embodiments, the transmembrane domain is selected from the group consisting of CD28, CD43, CD49d, CD62L, CD162, HLA-A2, HLA-DRA, ICAM1, LFA-1, mCD3z, mCD4, mCD8a, hCD8a, hCD8a, and VSVG-TM. Non-limiting exemplary embodiments of possible transmembrane domains for use in any of the fusion proteins disclosed herein include: [00231] CD28 FWVLVVVGGVLACYSLLVTVAFIIFWV (SEQ ID NO: 363)

[00232] CD43

GMLPVAVLVALLAVIVLVALLLLWRRRQKRRT (SEQ ID NO: 364)

[00233] CD49d

IVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKS (SEQ ID NO: 365)

[00234] CD62L

PLFIPVAVMVTAFSGLAFIIWLARRLKKGKKSKR (SEQ ID NO: 366)

[00235] CD 162

LLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRN (SEQ ID NO: 367)

[00236] HLA-A2

IVGIIAGLVLFGAVITGAVVAAVMWRRKSSDRKG (SEQ ID NO: 368)

[00237] HLA-DRA

NVVCALGLTVGLVGIIIGTIFIIKGLRKSNAAERRGPL (SEQ ID NO: 369)

[00238] ICAM1

IVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRL (SEQ ID NO: 370)

[00239] LFA-1

YLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLK (SEQ ID NO: 371)

[00240] mCD3z

LCYLLDGILFIYGVIITALYL (SEQ ID NO: 372)

[00241] mCD4

VFLACVLGGSFGFLGFLGLCILC (SEQ ID NO: 373)

[00242] mCD8a IWAPLAGICVALLLSLIITLI (SEQ ID NO: 374)

[00243] hCD8a

IWAPLAGTCGVLLLSLVITLY (SEQ ID NO: 375)

[00244] VSVG-TM

IASFFFIIGLIIGLFLVLRVGIHLCIKLKHTKKRQIYTDIEMNRLGK (SEQ ID NO: 376)

[00245] VSVGss-TM:

GTNPIELVEGWFSSWKSSIASFFFIIGLIIGLFLVLRVGIHLCIKLKHTKKRQIYTDIEMN RLGKV (SEQ ID NO: 493)

[00246] In some embodiments, the transmembrane domain comprises an amino acid sequence that is at least 80%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of any SEQ ID NO:s: 363-376 or 493.

Viral envelope glycoprotein domain

[00247] In some embodiments, the eVLPs comprise a fusion protein comprising a viral envelope glycoprotein domain. Any suitable viral envelope glycoprotein domain known to one of ordinary skill in the art may be used to make the fusion proteins contemplated herein. In some embodiments, the viral envelope glycoprotein comprises one or more mutations, for example, a mutation that decreases the glycoproteins binding affinity for its native target receptor. In some embodiment, the mutation does not substantially reduce the fugsionic properties (e.g., the ability to induce endocytic transduction). Non-limiting exemplary embodiments of possible viral envelope glycoprotein domains for use in any of the fusion proteins disclosed herein include:

[00248] VSV-Gmut amino acid sequence (K47Q/R354A, del 1-16, VSVGTM ^ASP)

KFTIVFPHNQKGNWKNVPSNYHYCPSSSDLNWHNDLIGTALQVKMPQSHKAIQADG WMCHASKWVTTCDFRWYGPKYITHSIRSFTPSVEQCKESIEQTKQGTWLNPGFPPQS CGYATVTDAEAVIVQVTPHHVLVDEYTGEWVDSQFINGKCSNYICPTVHNSTTWHS DYKVKGLCDSNLISMDITFFSEDGELSSLGKEGTGFRSNYFAYETGGKACKMQYCK HWGVRLPSGVWFEMADKDLFAAARFPECPEGSSISAPSQTSVDVSLIQDVERILDYSL CQETWSKIRAGLPISPVDLSYLAPKNPGTGPAFTIINGTLKYFETRYIRVDIAAPILSRM VGMISGTTTEAELWDDWAPYEDVEIGPNGVLRTSSGYKFPLYMIGHGMLDSDLHLS

SKAQVFEHPHIQDAASQLPDDESLFFGDTGLSKNPIELVEGWFSSWKSSIASFFFIIGLII

GLFLVLRVGIHLCIKLKHTKKRQIYTDIEMNRLGK (SEQ ID NO: 377)

[00249] VSV-Gmut amino acid sequence (K47Q/R354A):

MKCLLYLAFLFIGVNCKFTIVFPHNQKGNWKNVPSNYHYCPSSSDLNWHNDLIGTA

LQVKMPQSHKAIQADGWMCHASKWVTTCDFRWYGPKYITHSIRSFTPSVEQCKESI

EQTKQGTWLNPGFPPQSCGYATVTDAEAVIVQVTPHHVLVDEYTGEWVDSQFINGK

CSNYICPTVHNSTTWHSDYKVKGLCDSNLISMDITFFSEDGELSSLGKEGTGFRSNYF

AYETGGKACKMQYCKHWGVRLPSGVWFEMADKDLFAAARFPECPEGSSISAPSQTS

VDVSLIQDVERILDYSLCQETWSKIRAGLPISPVDLSYLAPKNPGTGPAFTIINGTLKY

FETRYIRVDIAAPILSRMVGMISGTTTEAELWDDWAPYEDVEIGPNGVLRTSSGYKFP

LYMIGHGMLDSDLHLSSKAQVFEHPHIQDAASQLPDDESLFFGDTGLSKNPIELVEG

WFSSWKSSIASFFFIIGLIIGLFLVLRVGIHLCIKLKHTKKRQIYTDIEMNRLGK (SEQ

ID NO: 378)

[00250] VSVG amino acid sequence:

MKCLLYLAFLFIGVNCKFTIVFPHNQKGNWKNVPSNYHYCPSSSDLNWHNDLIGTA

LQVKMPKSHKAIQADGWMCHASKWVTTCDFRWYGPKYITHSIRSFTPSVEQCKESI

EQTKQGTWLNPGFPPQSCGYATVTDAEAVIVQVTPHHVLVDEYTGEWVDSQFINGK

CSNYICPTVHNSTTWHSDYKVKGLCDSNLISMDITFFSEDGELSSLGKEGTGFRSNYF

AYETGGKACKMQYCKHWGVRLPSGVWFEMADKDLFAAARFPECPEGSSISAPSQTS

VDVSLIQDVERILDYSLCQETWSKIRAGLPISPVDLSYLAPKNPGTGPAFTIINGTLKY

FETRYIRVDIAAPILSRMVGMISGTTTERELWDDWAPYEDVEIGPNGVLRTSSGYKFP

LYMIGHGMLDSDLHLSSKAQVFEHPHIQDAASQLPDDESLFFGDTGLSKNPIELVEG

WFSSWKSSIASFFFIIGLIIGLFLVLRVGIHLCIKLKHTKKRQIYTDIEMNRLGK (SEQ

ID NO: 379)

[00251] VSVGmut2 (K47Q, R354Q):

MKCLLYLAFLFIGVNCKFTIVFPHNQKGNWKNVPSNYHYCPSSSDLNWHNDLIGTA

LQVKMPQSHKAIQADGWMCHASKWVTTCDFRWYGPKYITHSIRSFTPSVEQCKESI

EQTKQGTWLNPGFPPQSCGYATVTDAEAVIVQVTPHHVLVDEYTGEWVDSQFINGK

CSNYICPTVHNSTTWHSDYKVKGLCDSNLISMDITFFSEDGELSSLGKEGTGFRSNYF AYETGGKACKMQYCKHWGVRLPSGVWFEMADKDLFAAARFPECPEGSSISAPSQTS VDVSLIQDVERILDYSLCQETWSKIRAGLPISPVDLSYLAPKNPGTGPAFTIINGTLKY FETRYIRVDIAAPILSRMVGMISGTTTEQELWDDWAPYEDVEIGPNGVLRTSSGYKFP LYMIGHGMLDSDLHLSSKAQVFEHPHIQDAASQLPDDESLFFGDTGLSKNPIELVEG WFSSWKSSIASFFFIIGLIIGLFLVLRVGIHLCIKLKHTKKRQIYTDIEMNRLGK (SEQ ID NO: 494)

[00252] Cocal:

MNFLLLTFIVLPLCSHAKFSIVFPQSQKGNWKNVPSSYHYCPSSSDQNWHNDLLGIT MKVKMPKTHKAIQADGWMCHAAKWITTCDFRWYGPKYITHSIHSIQPTSEQCKESI KQTKQGTWMSPGFPPQNCGYATVTDSVAVVVQATPHHVLVDEYTGEWIDSQFPNG KCETEECETVHNSTVWYSDYKVTGLCDATLVDTEITFFSEDGKKESIGKPNTGYRSN

YFAYEKGDKVCKMNYCKHAGVRLPSGVWFEFVDQDVYAAAKLPECPVGATISAPT QTSVDVSLILDVERILDYSLCQETWSKIRSKQPVSPVDLSYLAPKNPGTGPAFTIINGT LKYFETRYIRIDIDNPIISKMVGKISGSQTERELWTEWFPYEGVEIGPNGILKTPTGYKF PLFMIGHGMLDSDLHKTSQAEVFEHPHLAEAPKQLPEEETLFFGDTGISKNPVELIEG WFSSWKSTVVTFFFAIGVFILLYVVARIVIAVRYRYQGSNNKRIYNDIEMSRFRK (SEQ ID NO: 495)

[00253] Cocalmut:

MNFLLLTFIVLPLCSHAKFSIVFPQSQKGNWKNVPSSYHYCPSSSDQNWHNDLLGIT MKVKMPQTHKAIQADGWMCHAAKWITTCDFRWYGPKYITHSIHSIQPTSEQCKESI KQTKQGTWMSPGFPPQNCGYATVTDSVAVVVQATPHHVLVDEYTGEWIDSQFPNG KCETEECETVHNSTVWYSDYKVTGLCDATLVDTEITFFSEDGKKESIGKPNTGYRSN

YFAYEKGDKVCKMNYCKHAGVRLPSGVWFEFVDQDVYAAAKLPECPVGATISAPT QTSVDVSLILDVERILDYSLCQETWSKIRSKQPVSPVDLSYLAPKNPGTGPAFTIINGT LKYFETRYIRIDIDNPIISKMVGKISGSQTEAELWTEWFPYEGVEIGPNGILKTPTGYKF PLFMIGHGMLDSDLHKTSQAEVFEHPHLAEAPKQLPEEETLFFGDTGISKNPVELIEG WFSSWKSTVVTFFFAIGVFILLYVVARIVIAVRYRYQGSNNKRIYNDIEMSRFRK (SEQ ID NO: 496)

[00254] Nipah-G: MPAENKKVRFENTTSDKGKIPSKVIKSYYGTMDIKKINEGLLDSKILSAFNTVIALLGS

IVIIVMNIMIIQNYTRSTDNQAVIKDALQGIQQQIKGLADKIGTEIGPKVSLIDTSSTITIP

ANIGLLGSKISQSTASINENVNEKCKFTLPPLKIHECNISCPNPLPFREYRPQTEGVSNL

VGLPNNICLQKTSNQILKPKLISYTLPVVGQSGTCITDPLLAMDEGYFAYSHLERIGSC

SRGVSKQRIIGVGEVLDRGDEVPSLFMTNVWTPPNPNTVYHCSAVYNNEFYYVLCA

VSTVGDPILNSTYWSGSLMMTRLAVKPKSNGGGYNQHQLALRSIEKGRYDKVMPY

GPSGIKQGDTLYFPAVGFLVRTEFKYNDSNCPITKCQYSKPENCRLSMGIRPNSHYIL

RSGLLKYNLSDGENPKVVFIEISDQRLSIGSPSKIYDSLGQPVFYQASFSWDTMIKFGD

VLTVNPLVVNWRNNTVISRPGQSQCPRFNTCPEICWEGVYNDAFLIDRINWISAGVFL

DSNQTAENPVFTVFKDNEILYRAQLASEDTNAQKTITNCFLLKNKIWCISLVEIYDTG

DNVIRPKLFAVKIPEQCT (SEQ ID NO: 497)

[00255] Nipah-Gmut:

MPAENKKVRFENTTSDKGKIPSKVIKSYYGTMDIKKINEGLLDSKILSAFNTVIALLGS

IVIIVMNIMIIQNYTRSTDNQAVIKDALQGIQQQIKGLADKIGTEIGPKVSLIDTSSTITIP

ANIGLLGSKISQSTASINENVNEKCKFTLPPLKIHECNISCPNPLPFREYRPQTEGVSNL

VGLPNNICLQKTSNQILKPKLISYTLPVVGQSGTCITDPLLAMDEGYFAYSHLERIGSC

SRGVSKQRIIGVGEVLDRGDEVPSLFMTNVWTPPNPNTVYHCSAVYNNEFYYVLCA

VSTVGDPILNSTYWSGSLMMTRLAVKPKSNGGGYNQHQLALRSIEKGRYDKVMPY

GPSGIKQGDTLYFPAVGFLVRTEFKYNDSNCPITKCQYSKPENCRLSMGIRPNSHYIL

RSGLLKYNLSDGENPKVVFIEISDQRLSIGSPSKIYDSLGQPVFYQASFSWDTMIKFGD

VLTVNPLVVNWRNNTVISRPGQSQCPRFNTCPAICAEGVYNDAFLIDRINWISAGVFL

DSNATAANPVFTVFKDNEILYRAQLASEDTNAQKTITNCFLLKNKIWCISLVEIYDTG

DNVIRPKLFAVKIPEQCT (SEQ ID NO: 498)

[00256] Nipah-Gmut trunc:

MKKINEGLLDSKILSAFNTVIALLGSIVIIVMNIMIIQNYTRSTDNQAVIKDALQGIQQQ

IKGLADKIGTEIGPKVSLIDTSSTITIPANIGLLGSKISQSTASINENVNEKCKFTLPPLKI

HECNISCPNPLPFREYRPQTEGVSNLVGLPNNICLQKTSNQILKPKLISYTLPVVGQSG

TCITDPLLAMDEGYFAYSHLERIGSCSRGVSKQRIIGVGEVLDRGDEVPSLFMTNVW

TPPNPNTVYHCSAVYNNEFYYVLCAVSTVGDPILNSTYWSGSLMMTRLAVKPKSNG

GGYNQHQLALRSIEKGRYDKVMPYGPSGIKQGDTLYFPAVGFLVRTEFKYNDSNCPI

TKCQYSKPENCRLSMGIRPNSHYILRSGLLKYNLSDGENPKVVFIEISDQRLSIGSPSKI YDSLGQPVFYQASFSWDTMIKFGDVLTVNPLVVNWRNNTVISRPGQSQCPRFNTCP

AICAEGVYNDAFLIDRINWISAGVFLDSNATAANPVFTVFKDNEILYRAQLASEDTNA

QKTITNCFLLKNKIWCISLVEIYDTGDNVIRPKLFAVKIPEQCT (SEQ ID NO: 499)

[00257] Nipah-F:

MVVILDKRCYCNLLILILMISECSVGILHYEKLSKIGLVKGVTRKYKIKSNPLTKDIVI KMIPNVSNMSQCTGSVMENYKTRLNGILTPIKGALEIYKNNTHDLVGDVRLAGVIM AGVAIGIATAAQITAGVALYEAMKNADNINKLKSSIESTNEAVVKLQETAEKTVYVL TALQDYINTNLVPTIDKISCKQTELSLDLALSKYLSDLLFVFGPNLQDPVSNSMTIQAI SQAFGGNYETLLRTLGYATEDFDDLLESDSITGQIIYVDLSSYYIIVRVYFPILTEIQQA YIQELLPVSFNNDNSEWISIVPNFILVRNTLISNIEIGFCLITKRSVICNQDYATPMTNN MRECLTGSTEKCPRELVVSSHVPRFALSNGVLFANCISVTCQCQTTGRAISQSGEQTL LMIDNTTCPTAVLGNVIISLGKYLGSVNYNSEGIAIGPPVFTDKVDISSQISSMNQSLQ QSKDYIKEAQRLLDTVNPSLISMLSMIILYVLSIASLCIGLITFISFIIVEKKRNTYSRLED RRVRPTSSGDLYYIGT (SEQ ID NO: 500)

[00258] BaEVRLess:

MGFTTKIIFLYNLVLVYAGFDDPRKAIELVQKRYGRPCDCSGGQVSEPPSDRVSQVT CSGKTAYLMPDQRWKCKSIPKDTSPSGPLQECPCNSYQSSVHSSCYTSYQQCRSGNK TYYTATLLKTQTGGTSDVQVLGSTNKLIQSPCNGIKGQSICWSTTAPIHVSDGGGPLD TTRIKSVQRKLEEIHKALYPELQYHPLAIPKVRDNLMVDAQTLNILNATYNLLLMSN TSLVDDCWLCLKLGPPTPLAIPNFLLSYVTRSSDNISCLIIPPLLVQPMQFSNSSCLFSPS YNSTEEIDLGHVAFSNCTSITNVTGPICAVNGSVFLCGNNMAYTYLPTNWTGLCVLA TLLPDIDIIPGDEPVPIPAIDHFIYRPKRAIQFIPLLAGLGITAAFTTGATGLGVSVTQYT KLSNQLISDVQILSSTIQDLQDQVDSLAEVVLQNRRGLDLLTAEQGGICLALQEKCCF YVNKSGIVRDKIKTLQEELERRRKDLASNPLWTGLQGLLPYLLPFLGPLLTLLLLLTIG PCIFNRLTAFINDKLNIIHAM (SEQ ID NO: 501)

[00259] In some embodiments, the viral envelope glycoprotein domain comprises an amino acid sequence that is at least 80%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of any SEQ ID NO:s: 377-379 or 494- 501. Stalk domain

In some embodiments, the eVLPs comprise a fusion protein comprising a stalk domain. Any suitable stalk domain known to one of ordinary skill in the art may be used to make the fusion proteins contemplated herein. In some embodiments, the stalk domain is selected from the group consisting of hCD8a-l, hCD8a-2, hIgG4-CH3, mCD3z, mCD4, mCD8a-l, mCD8a-2, hCD8a’, mCD28, hCD8, CD8 hinge region, Siglec-4:12, Siglec-1, Siglec-2, Siglec-3, Siglec- 7, IgGl-CH3, IgG4-CH2CH3, IgGl-CH2CH3, IgGl-1, IgGl-2, IgG2, IgG3, and IgG4. In some embodiments, the stalk domain is selected from the group consisting of hCD8a-l, hCD8a-2, hIgG4-CH3, mCD3z, mCD4, mCD8a-l, mCD8a-2, hCD8a’, mCD28, hCD8, Siglec-4:12, IgGl-CH3, IgG4-CH2CH3, IgGl-CH2CH3, IgGl-1, IgGl-2, IgG2, IgG3, and IgG4. In some embodiments, the stalk domain is selected from the group consisting of mmIgG2_l, mmIgG2_2, and mmIgG2_3. In some embodiments, the stalk domain is selected from the group consisting of IgG3_l, IgG3_2, IgG3_3, IgG3_4, IgG3_5, IgG3_6, IgGl_3, IgGl_4, IgG3_7, IgG2_l, and IgGl_3. In some embodiments, stalk domain is selected from the group consisting of IgAl_l, IgAl_2, IgAl_3, IgAl_4, IgA2_l, IgA2_2, IgA2_3, and IgA2_4. In some embodiments, the stalk domain is selected from the group consisting of IgD_l, IgD_2, IgD_3, IgD_4, IgE, IgM_l, IgM_2, IgM_3, and IgGl_4.

[00260] Non-limiting exemplary embodiments of possible stalk domains for use in any of the fusion proteins disclosed herein include:

[00261] COMP:

GQSPLGSDLGPQMLRELQETNAALQDVRELLRQQVREITFLKNTVMECDACGMQQS VRTGLPSVR (SEQ ID NO: 502)

[00262] CD 8 a trunc:

TTTPAPRPPTPAPTIASQPLSLRPEAC (SEQ ID NO: 503)

[00263] CD8 hinge region

(TTTPAPRPPTPAPTIASQPLSLRPEAC) (SEQ ID NO: 894)

[00264] hCD8a-l TTTPAPRPPTPAPTIASQPLSLRPEACRPAAAVHTRGLDFACDIYIWAPLAGTCGVLLL

SLVITLYCS (SEQ ID. NO. 29)

[00265] hCD8a-2

TTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDI (SEQ ID. NO. 30)

[00266] hIgG4 CH3

PGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPP

VLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKS (SEQ

ID. NO. 31)

[00267] mCD3z

QSFGLLDPK (SEQ ID. NO. 32)

[00268] mCD4

LSEGDKVKMDSRIQVLSRGVNQT (SEQ ID. NO. 33)

[00269] mCD8a-l

NISNSVMYFSSVVPVLQKVNSTTTKPVLRTPSPVHPTGTSQPQRPEDCRPRGSVKGTG

LDFACDIY (SEQ ID. NO. 34)

[00270] mCD8a-2

TTTKPVLRTPSPVHPTGTSQPQRPEDCRPRGSVKGTGLDFACD (SEQ ID. NO. 35)

[00271] hCD8a’

KPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIY (SEQ ID. NO.

36)

[00272] mCD28

IEFMYPPPYLDNERSNGTIIHIKEKHLCHTQSSPKL (SEQ ID. NO. 37)

[00273] hCD8

IEVMYPPPYLDNERSNGTIIHVKGKHLCPSPLFPGPSKP (SEQ ID. NO. 38) [00274] Siglec-4:12

PPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVT

PAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQS

NPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSV

EFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSG

LVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAV (SEQ

ID. NO. 39)

[00275] Siglec 1

MGFLPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAI

WYYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSY

NFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQV

RLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRA

QSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ TKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFM (SEQ ID NO: 896).

[00276] Siglec 2

MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESF

ILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLND

SGQLGLRMESKTEKWMERIHLNVSERPFPLHIQLPPEIQESQEVTLTCLLNFSCYGYPI

QLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFL

SNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSL

KKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYA (SEQ ID NO: 897).

[00277] Siglec 3

MPLLLLLPLLWAGALAMDPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPV

HGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDN

GSYFFRMERGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQ

GTPPIFSWLSAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLN (SEQ ID NO: 898) [00278] Siglec 7

MLPLQLPPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQT

DSDPVHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRD ARMSDAGRYFFRMEKGNIKWNYKYDQLSVNVTALTHRPNILIPGTLESGCFQNLTCS VPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVT TNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPAR LSWTWRSLTLYPSQPSNPLVLELQVHLGDEGEFTCRAQNSLGSQHVSLNLSL (SEQ ID NO: 899).

[00279] IgGl-CH3

GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK (SEQ ID.

NO. 40)

[00280] IgG4-CH2CH3

FLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKT KPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREP QVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGS FFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK (SEQ ID. NO. 41)

[00281] IgGl-CH2CH3

GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKP REEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQ VYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFF LYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK (SEQ ID. NO. 42)

[00282] IgGl-1

EPKSPDKTHTCPPCP (SEQ ID. NO. 43)

[00283] IgGl-2

YVTVSSQDPAEPKSPDKTHTCPPCP (SEQ ID. NO. 44)

[00284] IgG2 ERKCCVEVPPCP (SEQ ID. NO. 45)

[00285] IgG3

ELKTPLGDTHTCPRCP (SEQ ID. NO. 46)

[00286] IgG4

ESKYGPPCPPCP (SEQ ID. NO. 47)

[00287] Linker C2

ETIRESKYGPPCPPCPGGGGSVP (SEQ ID. NO. 48)

[00288] CAR Spacer XS

YVTVSSQDPAEPKSPDKTHTCPPCPKGKHLCPSPLFPGPSKP (SEQ ID. NO. 49)

[00289] CAR Spacer IS

YVTVSSQDPAEPKSPDKTHTCPPCPGGGGSAKPSAPWSGPAARATPQ

HTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHST

AKVVLTREDVHSQVICEVAHVTLQGDPLRGTANLS (SEQ ID. NO. 50)

[00290] CAR Spacer 2S

YVTVSSQDPAEPKSPDKTHTCPPCPGGGGSVPPTLEVTQQPVRAENQ

VNVTCQVRKFYPQRLQL TWLENGNVSRTETASTVTENKDGTYNWMS

WLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVS (SEQ ID. NO. 51)

[00291] CAR spacer XIS

YVTVSSQDPAEPKSPDKTHTCPPCPGGGGSAKPSAPWSGPAARATPQ

HTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHST

AKVVLTREDVHSQVICEVAHVTLQGDPLRGTANLSGGGGSKGKHLCPS PLFPGPSKP (SEQ ID. NO. 52)

[00292] CAR spacer X2S

YVTVSSQDPAEPKSPDKTHTCPPCPGGGGSVPPTLEVTQQPVRAENQ

VNVTCQVRKFYPQRLQL TWLENGNVSRTETASTVTENKDGTYNWMS WLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVSKGKHLCPSPLFP GPSKP

(SEQ ID. NO. 53)

[00293] CAR spacer M

YVTVSSQDPAEPKSPDKTHTCPPCPGGGGSAKPSAPWSGPAARATPQ HTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHST AKVVLTREDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQ PVRAENQVNVTCQVRKFYPQRLQLTWLENGNVSRTETASTVTENKDG TYNWMSWLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVS (SEQ ID. NO. 54)

[00294] CAR spacer XM

YVTVSSQDPAEPKSPDKTHTCPPCPGGGGSAKPSAPWSGPAARATPQ HTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHST AKVVLTREDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQ PVRAENQVNVTCQVRKFYPQRLQLTWLENGNVSRTETASTVTENKDG TYNWMSWLLVNVSAH RDDVKL TCQVEHDGQPAVSKSHDLKVSKGKH LCPSPLFPG PSKP (SEQ ID. NO. 55)

[00295] CAR spacer L

YVTVSSQDPAEPKSPDKTHTCPPCPGGGGSVPPTLEVTQQPVRAENQ VNVTCQVRKFYPQRLQL TWLENGNVSRTETASTVTENKDGTYNWMS WLLVNVSAH RDDVKL TCQVEHDGQPAVSKSH DLKVSGGGGSAKPSAP WSGPAARATPQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVD PVGESVSYSIHSTAKWLTREDVHSQVICEVAHVTLQGDPLRGTANLSE TIRVPPTLEVTQQPVRAENQVNVTCQVRKFYPQRLQL TWLENGNVSR TET ASTVTENKDGTYNWMSWLLVNVSAHRDDVKL TCQVEH DGQPAV SKSHDLKVS (SEQ ID. NO. 56)

[00296] CAR spacer XL

YVTVSSQDPAEPKSPDKTHTCPPCPGGGGSVPPTLEVTQQPVRAENQ VNVTCQVRKFYPQRLQL TWLENGNVSRTETASTVTENKDGTYNWMS WLLVNVSAH RDDVKL TCQVEHDGQPAVSKSH DLKVSGGGGSAKPSAP WSGPAARATPQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVD PVGESVSYSIHSTAKWLTREDVHSQVICEVAHVTLQGDPLRGTANLSE

TIRVPPTLEVTQQPVRAENQVNVTCQVRKFYPQRLQL TWLENGNVSR TET ASTVTENKDGTYNWMSWLLVNVSAHRDDVKL TCQVEH DGQPAV SKSHDLKVSKGKHLCPSPLFPGPSKP (SEQ ID. NO. 57)

[00297] mmIgG2_l

KPCPPCKCP (SEQ ID. NO. 58)

[00298] mmIgG2_2

KPCPPCKCPAP (SEQ ID. NO. 59)

[00299] mmIgG2_3

GPTIKPCPPCKCPAP (SEQ ID. NO. 60)

[00300] IgG3_l

ELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPR

CPAP (SEQ ID. NO. 61)

[00301] IgG3_2

CPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPAP (SEQ ID.

NO. 62)

[00302] IgG3_3

EPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPAP (SEQ ID. NO. 63)

[00303] IgG3_4

EPKSCDTPPPCPRCPEPKSCDTPPPCPRCPAP (SEQ ID. NO. 64)

[00304] IgG3_5

CPRCPEPKSCDTPPPCPRCPAP (SEQ ID. NO. 65)

[00305] IgG3_6

EPKSCDTPPPCPRCPAP (SEQ ID. NO. 66) [00306] IgGl_3

EPKSCDKTHTCPPCPAP (SEQ ID. NO. 67)

[00307] IgGl_4

PKSCDKTHTCPPCPAP (SEQ ID. NO. 68)

[00308] IgG3_7

PCPRCPAP (SEQ ID. NO. 69)

[00309] IgG2_l

PCPAPPVAG PS (SEQ ID. NO. 70)

[00310] IgGl_3

PPKPKDT (SEQ ID. NO. 71)

[00311] IgAl_l

TVPCPVPSTPPTPSPSTPPTPSPSCCHP (SEQ ID. NO. 72)

[00312] IgA 1_2

TVPCPVPSTP (SEQ ID. NO. 73)

[00313] IgA 1_3

TPSPSTPPTP (SEQ ID. NO. 74)

[00314] IgA 1_4

TPSPSCCHP (SEQ ID. NO. 75)

[00315] IgA2_l

VPCPVPPPPPCCHPR (SEQ ID. NO. 76)

[00316] IgA2_2

VPCPVPP (SEQ ID. NO. 77) [00317] IgA2_3

PPPCCHP (SEQ ID. NO. 78)

[00318] IgA2_4

PCPVPPPPPCCHP (SEQ ID. NO. 79)

[00319] IgD_l

RWPESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEER

ETKTPE CP5HTQPLGVYLLTP (SEQ ID. NO. 80)

[00320] IgD_2

KTPECPSHTQPLGVYLLTP (SEQ ID. NO. 81)

[00321] IgD_3

PECPSHTQPLGVYLLTP (SEQ ID. NO. 82)

[00322] IgD_4

RWPESPKAQASSVP (SEQ ID. NO. 83)

[00323] IgE

SVCSRDFTPP (SEQ ID. NO. 84)

[00324] IgM_l

PLPVIAELPPKVSVFVPPRDGFFGNP (SEQ ID. NO. 85)

[00325] IgM_2

PLPVIAELPP (SEQ ID. NO. 86)

[00326] IgM_3

ELPPKVSVFVPP (SEQ ID. NO. 87)

[00327] IgGl_4 AEPKSPDKTHTCPPCPKDPK (SEQ ID. NO. 88)

[00328] PDGFR

WSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLR (SEQ ID NO: 404)

[00329] In some embodiments, the stalk domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of any SEQ ID NO:s: 29-88, 404, 502-503, 894, or 896-899.

Targeting domain

[00330] In some embodiments, the eVLPs comprise a fusion protein comprising a targeting domain. Any suitable targeting domain known to one of ordinary skill in the art may be used to make the fusion proteins contemplated herein. In some embodiments, the targeting domain is a cytokine. In some embodiments, the targeting domain is a protein. Other targeting domains are possible in other embodiments. For example, in certain embodiments, the targeting domain is a (poly)nucleic acid, a glycoprotein, a protein, a peptide, or a small molecule. In some embodiments, the targeting domain comprises an antibody or an aptamer.

[00331] In some embodiments, the targeting domain is not a viral envelope glycoprotein. In other embodiments the targeting domain is not a fragment of an antibody domain.

[00332] In some embodiments, the targeting domain is configured to bind to a specific target, e.g., a receptor on a specific cell type. The target domain, according to some embodiments, preferentially binds to human hematopoietic stem and progenitor cell (e.g., HSPCs). Without wishing to be bound by any particular theory, it is believed that HSPCs comprise a plurality of cell types. In some embodiments, the target cell type within the family of HSPC cells is the long term HSCs (LT-HSCs) which have both self-renewal and multi-lineage potential. Other target cells within the HSPC family of cells include short term HSCs (ST-HSCs), Multi-Potent Progenitor cells (MPPs), Common Myeloid Progenitor cells (CMPs), Common Lymphoid Progenitor cells (CLPs), Megakaryocyte-erythroid progenitor cells (MEPs), granulocyte-monocyte progenitor cells (GMPs), neutrophils, megakaryocytes, platelets, erythrocytes, monocytes, macrophages, basophils, lymphocytes, dendritic cells, T cells, B cells, according to other embodiments.

[00333] Again, without wishing to be bound by any particular theory, it is believed that the cells within the HSPC family may be identified by various surface markers. For example, cells expressing CD201⁺CD150⁺CD48- Lin‘ c-Kit⁺Sca-l⁺ or CD34-Flk2^_Lin-c-Kit⁺Sca-l⁺ are considered in the art to be LT-HSC cells, according to some embodiments. LT-HSC cells can be further differentiated into ST-HSC cells which express CD34⁺Flk2-Lin-c-Kit⁺ Sca-l⁺, in other embodiments. ST-HSC cells may then differentiate into MPP cells expressing CD34⁺Flk2⁺Lin-c-Kit⁺Sca-l⁺ or CD150-CD48-Lin^_c-Kit⁺Sca-l⁺, according to certain embodiments. MPP cells may then either differentiate into CMP cells (e.g., expressing CD34⁺FcyRIVIII^lowLin^_c-Kit⁺Sca-l-) or CLP cells (e.g., expressing Lin-c-Kit^lowSca- l^lowIL7Ra⁺Flk2⁺), according to another set of embodiments. CMP cells may further differentiate into MEP cells (e.g., expressing CD34+FcyRIFIIl-Lin-c-Kit+Sca-l-) or GMP cells (e.g., expressing CD34+FcyRIFIII+Lin-c-Kit+Sca-l-); whereas CLP cells further differentiate into dendritic cells, T-cells, NK cells, and B-cells. MEP cells are known to further differentiate into megakaryocytes and erythrocytes; whereas GMP cells may differentiate into basophils, neutrophils, eosinophils, monocytes, and dendritic cells.

Monocytes may also further differentiate into macrophages and monocyte derived dendritic cells.

[00334] In some embodiments, the targeting domain binds to target proteins on T cells and/or B cells. Exemplary targeting domains and their target receptor on T cells are shown below:

Exemplary targeting domains and their target receptor on B cells are shown below:

[00335] In some embodiments, the targeting domain may bind to any known “receptor” on a target cell surface. Those of skill in the art will understand that the term “receptor” as used herein does not require any signaling event to occur upon binding of the targeting domain to the target receptor, although such a signaling event is not precluded from occurring. As such, the receptor may be any moiety present on the cell surface, including but not limited to glycoproteins, proteins (e.g., globular proteins, lipid anchored proteins, peripheral proteins), carbohydrates, glycolipids, lipids, and/or complexes formed therefrom. Exemplary receptor: targeting domains contemplated herein include, but are not limited to, CD110:Thrombopoientin (TPO), c-kit:Stem Cell Factor (SCF), CXCR4:CXCL12, CD46:Adenovirus F35 (AdF35), CD201:Protein C, CD150:SH2DlA/EAT-2, CD45:CMV ULll/PP14/adenovirus E3, CD54:LFA-1, CD55:CD97, CD58:CD2, CD59:CD2, CD100:Plexin-B2, CD120:TNFa/b, CD124:IL-4, and Flk2:Flt3.

[00336] Non-limiting exemplary embodiments of possible targeting domains for use in any of the fusion proteins disclosed herein include:

[00337] CALR-del52

[00338] LLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVL SSGKFYGDEEKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGG YVKLFPNSLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKD DEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDASKPEDWDER AKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPR QIDNPDYKGTWIHPEIDNPEYSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDE AYAEEFGNETWGVTKAAEKQMKDKQDEEQRTRRMMRTKMRMRRMRRTRRKMRR KMSPARPRTSCREACLQGWTEA (SEQ ID NO: 343)

[00339] CALR-ins5

[00340] LLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVL SSGKFYGDEEKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGG YVKLFPNSLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKD DEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDASKPEDWDER AKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPR QIDNPDYKGTWIHPEIDNPEYSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDE AYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDNCRRMM

RTKMRMRRMRRTRRKMRRKMSPARPRTSCREACLQGWTEA (SEQ ID NO: 344)

[00341] CXCL12

[00342] NAKVVVVLVLVLTALCLSDGKPVSLSYRCPCRFFESHVARANVKHLKILN

TPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNK (SEQ ID NO: 345)

[00343] AdF35

TKRVRLSDSFNPVYPYEDESTSQHPFYNPGFISPNGFTQSPDGVLTLKCLTPLTTTGGS

LQLKVGGGLTVDDTDGTLQENIRATAPITKNNHSVELSIGNGLETQNNKLCAKLGNG

LKFNNGDICIKDSINTLWTGINPPPNCQIVENTNTNDGKLTLVLVKNGGLVNGYVSLV GVSDTVNQMFTQKTANIQLRLYFDSSGNLLTEESDLKIPLKNKSSTATSETVASSKAF MPSTTAYPFNTTTRDSENYIHGICYYMTSYDRSLFPLNISIMLNSRMISSNVAYAIQFE

WNLNASESPESNIATLTTSPFFFSYITEDDN (SEQ ID NO: 346)

[00344] mSCF soluble

EICGDPVTDNVKDITKLVANLPNDYMITLNYVAGMDVLPSHCWLRDMLIQLSLSLTT

LLDKLSNISEGLSNYSIIHKLGIIVDDLFFCMEENAPKNRKEFPKRPETRSFTPEEFFSIF

NRSIDAFKDFMVASDTSDCVLSSTLGPEKDSRVSVTKPFMLPPVAAS (SEQ ID NO: 347)

[00345] mSCF soluble (V49L/F63L)

EICGDPVTDNVKDITKLVANLPNDYMITLNYVAGMDVLPSHCWLRDMLIQLSLSLTT

LLDKLSNISEGLSNYSIIHKLGIIVDDLFFCMEENAPKNIKEFPKRPETRSFTPEEFFSIFN RSIDAFKDFMVASDTSDCVLSSTLGPEKDSRVSVTKPFMLPPVAAS (SEQ ID NO: 387)

[00346] SCF

KKTQTWILTCIYLQLLLFNPLVKTEGICRNRVTNNVKDVTKLVANLPKDYMITLKYV

PGMDVLPSHCWISEMVVQLSDSLTDLLDKFSNISEGLSNYSIIDKLVNIVDDLVECVK ENSSKDLKKSFKSPEPRLFTPEEFFRIFNRSIDAFKDFVVASETSDCVVSSTLSPEKDSR VSVTKPFMLPPVAASSLRNDSSSSNRKAKNPPGDSSLHWAAMALPALFSLIIGFAFGA LYWKKRQPSLTRAVENIQINEEDNEISMLQEKEREFQEV (SEQ ID NO: 348) [00347] SCF mutant (V49L/F63L/K91E/I98R)

KKTQTWILTCIYLQLLLFNPLVKTEGICRNRVTNNVKDVTKLVANLPKDYMITLKYV PGMDVLPSHCWISEMLVQLSDSLTDLLDKLSNISEGLSNYSIIDKLVNIVDDLVECVE ENSSKDRKKSFKSPEPRLFTPEEFFRIFNRSIDAFKDFVVASETSDCVVSSTLSPEKDSR VSVTKPFMLPPVAASSLRNDSSSSNRKAKNPPGDSSLHWAAMALPALFSLIIGFAFGA

LYWKKRQPSLTRAVENIQINEEDNEISMLQEKEREFQEV (SEQ ID NO: 349)

[00348] SCF mutant (V49L/F63L/K9 IE)

KKTQTWILTCIYLQLLLFNPLVKTEGICRNRVTNNVKDVTKLVANLPKDYMITLKYV PGMDVLPSHCWISEMLVQLSDSLTDLLDKLSNISEGLSNYSIIDKLVNIVDDLVECVE ENSSKDLKKSFKSPEPRLFTPEEFFRIFNRSIDAFKDFVVASETSDCVVSSTLSPEKDSR VSVTKPFMLPPVAASSLRNDSSSSNRKAKNPPGDSSLHWAAMALPALFSLIIGFAFGA

LYWKKRQPSLTRAVENIQINEEDNEISMLQEKEREFQEV (SEQ ID NO: 350)

[00349] SCF mutant (V49L/F63L)

KKTQTWILTCIYLQLLLFNPLVKTEGICRNRVTNNVKDVTKLVANLPKDYMITLKYV PGMDVLPSHCWISEMLVQLSDSLTDLLDKLSNISEGLSNYSIIDKLVNIVDDLVECVK ENSSKDLKKSFKSPEPRLFTPEEFFRIFNRSIDAFKDFVVASETSDCVVSSTLSPEKDSR VSVTKPFMLPPVAASSLRNDSSSSNRKAKNPPGDSSLHWAAMALPALFSLIIGFAFGA

LYWKKRQPSLTRAVENIQINEEDNEISMLQEKEREFQEV (SEQ ID NO: 351)

[00350] SCF soluble

EGICRNRVTNNVKDVTKLVANLPKDYMITLKYVPGMDVLPSHCWISEMVVQLSDSL TDLLDKFSNISEGLSNYSIIDKLVNIVDDLVECVKENSSKDLKKSFKSPEPRLFTPEEFF RIFNRSIDAFKDFVVASETSDCVVSSTLSPEKDSRVSVTKPFMLPPVAA (SEQ ID NO:

352)

[00351] SCF soluble mutant (V49L/F63L/K91E/I98R)

EGICRNRVTNNVKDVTKLVANLPKDYMITLKYVPGMDVLPSHCWISEMLVQLSDSL TDLLDKLSNISEGLSNYSIIDKLVNIVDDLVECVEENSSKDRKKSFKSPEPRLFTPEEFF RIFNRSIDAFKDFVVASETSDCVVSSTLSPEKDSRVSVTKPFMLPPVAA (SEQ ID NO:

353) [00352] SCF soluble mutant (V49L/F63L/K9 IE)

EGICRNRVTNNVKDVTKLVANLPKDYMITLKYVPGMDVLPSHCWISEMLVQLSDSL

TDLLDKLSNISEGLSNYSIIDKLVNIVDDLVECVEENSSKDLKKSFKSPEPRLFTPEEFF

RIFNRSIDAFKDFVVASETSDCVVSSTLSPEKDSRVSVTKPFMLPPVAA (SEQ ID NO:

354)

[00353] SCF soluble mutant (V49L/F63L)

EGICRNRVTNNVKDVTKLVANLPKDYMITLKYVPGMDVLPSHCWISEMLVQLSDSL

TDLLDKLSNISEGLSNYSIIDKLVNIVDDLVECVKENSSKDLKKSFKSPEPRLFTPEEFF

RIFNRSIDAFKDFVVASETSDCVVSSTLSPEKDSRVSVTKPFMLPPVAA (SEQ ID NO:

355)

[00354] TPO-157

ELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTP

VLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLS

GQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLR (SEQ ID NO: 356)

[00355] TPO-163

ELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTP

VLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLS

GQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFL (SEQ ID NO: 357)

[00356] TPO-171

ELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTP

VLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLS

GQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTL

(SEQ ID NO: 358)

[00357] TPO

ELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTP

VLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLS GQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLC VRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIP GLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQ PGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNL SQEG (SEQ ID NO: 359)

[00358] CXCL11

MSVKGMAIALAVILCATVVQGFPMFKRGRCLCIGPGVKAVKVADIEKASIMYPSNN DKIEVIITLKENKGQRCLNPKSKQARLIIKKVERKNF(SEQ ID NO: 360)

[00359] CXCL4

MSSAAGFCASRPGLLFLGLLLLPLVVAFASAEAEEDGDLQCLCVKTTSQVRPRHITSL EVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES (SEQ ID NO: 361)

[00360] CXCL14 (SEQ ID NO: 362)

MRLLAAALLLLLLALYTARVDGSKCKCSRKGPKIRYSDVKKLEMKPKYPHCEEKM VIITTKSVSRYRGQEHCLHPKLQSTKRFIKWYNAWNEKRRVYEE (SEQ ID NO: 362)

[00361] 53E11 a-hCD8 DARPin

MDLGKKLLEAARAGQDDEVRILMTNGADVNALDQAGSTPLHLAAWHGHLEIVEVL LKYGADVNASDIIGQTPLHLAALNGHLEIVEVLLKNGADVNARDRLGETPLHLAAFD GHLEIVEVLLKYDADVNAQDKFGKTPFDLAIDNGNEDIAEVLQKAA (SEQ ID NO: 900).

[00362] CD8 51.1-Xencor-H1L1 scFv

MQIQLVQSGAEVKKPGASVKVSCKASGYSFTNFGMIWRQAPGQGLEWMGWINTYT GEPTYADGFTGRFVFSLQTSVNTAYLQISSLKAEDTAVYFCARKQYAGFFDYWGQG TLVTVSSGGGGSGGGGSGGGGSDILMTQSPSSLSASVGDRVTITCQASQDIGSNMGW LQQKPGKSFKALIYHGINLEYGVPSRFSGSGSGADYTLTISSLQPEDFATYYCVQFAQ FPYTFGGGTKVEIK (SEQ ID NO: 901). [00363] 53F6 a-hCD8 DARPin

DLGKKLLEASRAGQDDEVRILMANGADVNAQDRYGTTPLHLAAWHGHLEIVEVLL KHGADVNANDVKGNTPLHLAANVGHLEIVEVLLKYGADVNAADNWGHTPLHLAA FWGHLEIVEVLLKYGADVNAQDKFGKTPFDLAIDNGNEDIAEVLQKAA (SEQ ID NO: 902).

[00364] 53F6 a-hCD8 DARPin

DLGKKLLEASRAGQDDEVRILMANGADVNAQDRYGTTPLHLAAWHGHLEIVEVLL KHGADVNANDVKGNTPLHLAANVGHLEIVEVLLKYGADVNAADNWGHTPLHLAA FWGHLEIVEVLLKYGADVNAQDKFGKTPFDLAIDNGNEDIAEVLQKAA (SEQ ID NO: 903).

[00365] 63A4 a-hCD8 DARPin

MDLGKKLLEAVRAGKDDEVRILMANGADVNAEDTQGNTPLHLVAWHGHLEIVEVL LKYGADVNASDIIGQTPLHLAALNGHLEIVEVLLKYGADVNAWDRHGHTPLHLAAY FGHLEIVEVLLKNGADVNAQDKFGKTPFDLAIDNGNEDIAEVLQKAA (SEQ ID NO: 904).

[00366] Acapatamab

CDQVQLVESGGGLVKPGESLRLSCAASGFTFSDYYMYWVRQAPGKCLEWVAIISDG GYYTYYSDIIKGRFTISRDNAKNSLYLQMNSLKAEDTAVYYCARGFPLLRHGAMDY WGQGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCKASQNVD TNVAWYQQKPGQAPCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATY YADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWG QGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGN YPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYY CVLWY (SEQ ID NO: 905).

[00367] Acapatamab Vh-Vk

QVQLVESGGGLVKPGESLRLSCAASGFTFSDYYMYWVRQAPGKCLEWVAIISDGGY YTYYSDIIKGRFTISRDNAKNSLYLQMNSLKAEDTAVYYCARGFPLLRHGAMDYWG QGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCKASQNVDTNV AWYQQKPGQAPCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYA

DSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVR (SEQ ID NO: 906).

[00368] Acapatamab Vh-Vl

EVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKY

NNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISY WAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTG AVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPE DEAEYYCVLWYSNRWVFGGGTKLTVL (SEQ ID NO: 907).

[00369] CD3 DARPin-C7vl4

MDLGQKLLEAAWAGQDDEVRILLAAGADVNAKNSRGWTPLHTAAQTGHLEIFEVL LKAGADVNAKNDKRVTPLHLAAALGHLEIVEVLLKAGADVNARDSWGTTPADLAA KYGHGDIAEVLQKAA (SEQ ID NO: 908).

[00370] CD3 DARPin-C7v 118

MDLGQKLLEAAWAGQDDEVRELLKAGADVNAKDSQGWTPLHTAAQTGHLEIFEVL LKAGADVNAKDDKGVTPLHLAAALGHLEIVEVLLKAGADVNAQDSWGTTPADLAA KYGHEDIAEVLQKAA (SEQ ID NO: 909).

[00371] CD3 DARPin-C7vll9

MDLGQKLLEAAWAGQDDEVRELLKAGADVNAKNSRGWTPLHTAAQTGHLEIFEVL LKAGADVNAKDDKGVTPLHLAAALGHLEIVEVLLKAGADVNAQDSWGTTPADLAA KYGHEDIAEVLQKAA (SEQ ID NO: 910).

[00372] CD3 DARPin-C7vl22

MDLGQKLLEAAWAGQDDEVRELLKAGADVNAKNSRGWTPLHTAAQTGHLEIFEVL LKAGADVNAKNDKRVTPLHLAAALGHLEIVEVLLKAGADVNARDSWGTTPADLAA KYGHQDIAEVLQKAA (SEQ ID NO: 911). [00373] CD3 DARPin-C7vl27

MDLGQKLLEAAWAGQLDEVRILLKAGADVNAKNSRGWTPLHTAAQTGHLEIFEVL LKAGADVNAKTNKRVTPLHLAAALGHLEIVEVLLKAGADVNARDTWGTTPADLAA KYGHRDIAEVLQKAA (SEQ ID NO: 912).

[00374] scFv-CD3-l

MEVQLQQSGPELVKPGASMKISCKASGYSFTGYTMNWVKQSHGKNLEWMGLINPY KGVSTYNQKFKDKATLTVDKSSSTAYMELLSLTSEDSAVYYCARSGYYGDSDWYF DVWGAGTTVTVSSGGGGSGGGGSGGGGSDIQMTQTTSSLSASLGDRVTISCRASQDI RNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSKFSGSGSGTDYSLTISNLEQEDIATYF CQQGNTLPWTFAGGTKLEIK (SEQ ID NO: 913).

[00375] scFv-CD3-2

DIQMTQTTSSLSASLGDRVTISCRASQDIRNYLNWYQQKPDGTVKLLIYYTSRLHSG VPSKFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPWTFAGGTKLEIKGGGGSGGG GSGGGGSEVQLQQSGPELVKPGASMKISCKASGYSFTGYTMNWVKQSHGKNLEWM GLINPYKGVSTYNQKFKDKATLTVDKSSSTAYMELLSLTSEDSAVYYCARSGYYGD SDWYFDVWGAGTTVTVSS (SEQ ID NO: 914).

[00376] scFv-CD3-3

MQVQLQQSGAELARPGASVKMSCKASGYTFTRYTMHWVKQRPGQGLEWIGYINPS RGYTNYNQKFKDKATLTTDKSSSTAYMQLSSLTSEDSAVYYCARYYDDHYCLDYW GQGTTLTVSSGGGGSGGGGSGGGGSQIVLTQSPAIMSASPGEKVTMTCSASSSVSYM NWYQQKSGTSPKRWIYDTSKLASGVPAHFRGSGSGTSYSLTISGMEAEDAATYYCQ QWSSNPFTFGSGTKLEIN (SEQ ID NO: 915).

[00377] scFv-CD3-4

MEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSK YNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYIS YWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSST GAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQP EDEAEYYCVLWY (SEQ ID NO: 916). [00378] scFv-CD4-l

QVQLQQSGPEVVKPGASVKMSCKASGYTFTSYVIHWVRQKPGQGLDWIGYINPYND GTDYDEKFKGKATLTSDTSTSTAYMELSSLRSEDTAVYYCAREKDNYATGAWFAY WGQGTLVTVSSGGGGSGGGGSGGGGSDIVMTQSPDSLAVSLGERVTMNCKSSQSLL YSTNQKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSVQAE DVAVYYCQQYYSYRTFGGGTKLEIK (SEQ ID NO: 917).

[00379] scFv-CD4-2

MDIVMTQSPDSLAVSLGERVTMNCKSSQSLLYSTNQKNYLAWYQQKPGQSPKLLIY WASTRESGVPDRFSGSGSGTDFTLTISSVQAEDVAVYYCQQYYSYRTFGGGTKLEIK GGGGSGGGGSGGGGSQVQLQQSGPEVVKPGASVKMSCKASGYTFTSYVIHWVRQK PGQGLDWIGYINPYNDGTDYDEKFKGKATLTSDTSTSTAYMELSSLRSEDTAVYYC AREKDNYATGAWFAYWGQGTLVTVSS (SEQ ID NO: 918).

[00380] Sana CD 19 scFv FMC63 G4S linker

DIQMTQTTSSLSASLGDRVTISCRASQDISKYLNWYQQKPDGTVKLLIYHTSRLHSGV PSRFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPYTFGGGTKLEITGGGGSGGGG SGGGGSEVKLQESGPGLVAPSQSLSVTCTVSGVSLPDYGVSWIRQPPRKGLEWLGVI WGSETTYYNSALKSRLTIIKDNSKSQVFLKMNSLQTDDTAIYYCAKHYYYGGSYAM DYWGQGTSVTVSS (SEQ ID NO: 919).

[00381] Sana CD22 scFv m971-L7

QVQLQQSGPGMVKPSQTLSLTCAISGDSVSSNSVAWNWIRQSPSRGLEWLGRTYYR STWYNDYAVSMKSRITINPDTNKNQFSLQLNSVTPEDTAVYYCAREVTGDLEDAFDI WGQGTMVTVSSGGGGSGGGGSGGGGSDIQMIQSPSSLSASVGDRVTITCRASQTIWS YLNWYRQRPGEAPNLLIYAASSLQSGVPSRFSGRGSGTDFTLTISSLQAEDFATYYCQ

QSYSIPQTFGQGTKLEIK (SEQ ID NO: 920).

[00382] CD28 scFv

DIQMNQSPSSLSASLGDTITITCHASQNIYVWLNWYQQKPGNIPKLLIYKASNLHTGV PSRFSGSGSGTGFTLTISSLQPEDIATYYCQQGQTYPYTFGGGTKLEIKRADAAPTVSI FPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYS MSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNGGGGSGGGGSGGGGSSQVQ LQQSGPELVKPGTSVRISCEASGYTFTSYYIHWVKQRPGQGLEWIGCIYPGNVNTNY NEKFKDKATLIVDTSSNTAYMQLSRMTSEDSAVYFCTRSHYGLDWNFDVWGAGTT VTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHT FPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDC (SEQ ID NO: 921).

[00383] hCDl 17 scFv Ab54 CA3079215A1

QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGT ANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARGGLDTDEFDLWGRGT LVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSINSYLNWY QQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGVSDI TFGGGTKVEIK (SEQ ID NO: 922).

[00384] hCDl 17 scFv Ab55 CA3079215A1

QVQLVQSGAEVKKPGSSVKVSCKASGGTFRIYAISWVRQAPGQGLEWMGGIIPDFG VANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARGGLDTDEFDLWGRG TLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSINSYLNW YQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGVS DITFGGGTKVEIK (SEQ ID NO: 923).

[00385] hCDl 17 scFv Ab56 CA3079215A1

QVQLVQSGAEVKKPGSSVKVSCKASGGTFSLYAISWVRQAPGQGLEWMGGIIPAFG TANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARGGLDTDEFDLWGRG TLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSINSYLNW YQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGVS DITFGGGTKVEIK (SEQ ID NO: 924).

[00386] hCDl 17 scFv Ab57 CA3079215A1

QVQLVQSGAEVKKPGSSVKVSCKASGGTFSLYAISWVRQAPGQGLEWMGGIIPHFG LANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARGGLDTDEFDLWGRG TLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSINSYLNW YQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGVS DITFGGGTKVEIK (SEQ ID NO: 925). [00387] hCD117 scFv Ab61 CA3079215A1

EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYVMIWVRQAPGKGLEWVSSISGDSVT TYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGPPTYHTNYYYMDV WGKGTTVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSVSASVGDRVTITCRASQGISS WLAWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQ QTNSFPYTFGGGTKVEIK (SEQ ID NO: 926).

[00388] hCDl 17 scFv Ab66 CA3079215A1

EVQLVESGGGLVQPGGSLRLSCAASGFTFSDHYMDWVRQAPGKGLEWVGRTRNKA SSYTTEYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCAREPKYWIDFDLW GRGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSISSYL NWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQS YIAPYTFGGGTKVEIK (SEQ ID NO: 927).

[00389] hCDl 17 scFv Ab67 CA3079215A1

EVQLVESGGGLVQPGGSLRLSCAASGFTFSDADMDWVRQAPGKGLEWVGRTRNKA GSYTTEYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCAREPKYWIDFDLW GRGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSISSYL NWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQS YIAPYTFGGGTKVEIK (SEQ ID NO: 928).

[00390] hCDl 17 scFv Ab68 CA3079215A1

EVQLVESGGGLVQPGRSLRLSCTASGFTFSDHDMNWVRQAPGKGLEWVGRTRNAA GSYTTEYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCAREPKYWIDFDLW GRGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSISSYL NWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQS YIAPYTFGGGTKVEIK (SEQ ID NO: 929).

[00391] hCDl 17 scFv Ab69 CA3079215A1

EVQLVESGGGLVQPGGSLRLSCAASGFTFVDHDMDWVRQAPGKGLEWVGRTRNKL GSYTTEYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCAREPKYWIDFDLW GRGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSISSYL NWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQS

YIAPYTFGGGTKVEIK (SEQ ID NO: 930).

[00392] USPTO 6,054,297 genentech hCDl 17 scFv

EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYAMSWVRQAPGKGLEWVAVISENGS DTYYADSVKGRFTISRDDSKNTLYLQMNSLRAEDTAVYYCARDRGGAVSYFDVWG QGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQDVSSYL AWYQQKPGKAPKLLIYAASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQY NSLPYTFGQGTKVEIKRT (SEQ ID NO: 931).

[00393] Sana CD8 scFv form 1

QVQLVQSGAEVKKPGASVKVSCKASSYYIHMHWVRQAPGQGLEWMGRRINPKSGR TYYAQNFQGNYAQKFQGRVTSTRDTSISTAYMELSRLRSDDTVVYYCLTEGIPDYW GQGTTVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQNIGTW LAWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQ

SYSTPQTFGPGTKVDIKRFGGGTKVEIK (SEQ ID NO: 932).

[00394] Sana CD8 scFv form 2

QVQLVQSGAEVKKPGASVKVSCKASSYYIHMHWVRQAPGQGLEWMGRRINPKSGR TYYAQNFQGNYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTVVYYCLTEGIPDYW GQGTTVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQNIGTW LAWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQ SYSTPQTFGPGTKVDIKRFGGGTKVEIK (SEQ ID NO: 933).

[00395] Sana CD8 scFv form 3

QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVRQAPGQGLEWMGIRINPK SGRTYYAQNFQGSYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCLTEGIP DYWGQGTTVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQNI GTWLAWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYY CQQSYSTPQTFGPGTKVDIKRFGGGTKVEIK (SEQ ID NO: 934).

[00396] Sana CD8 scFv form 4 QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVRQAPGQGLEWMGRINPK SGRTNYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTVVYYCARLTEGIPDYWGQG TTVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQNIGTWLAW YQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYST PQTFGPGTKVDIKRFGGGTKVEIK (SEQ ID NO: 935).

[00397] Sana CD8 scFv form 5

QVQEVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVRQAPGQGEEWMGIINPKS GRTSYAQKFQGRVTMTRDTSTSTVYMEESSERSEDTAVYYCARETEGIPDYWGQGT TVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSESASVGDRVTITCRASQNIGTWEAWY QQKPGKAPKEEIYAASTEQSGVPSRFSGSGSGTDFTETISSEQPEDFATYYCQQSYSTP QTFGPGTKVDIKRFGGGTKVEIK (SEQ ID NO: 936).

[00398] Sana CD8 scFv form 6

DIQMTQSPSSLSASVGDRVTITCRASQNIGTWLAWYQQKPGKAPKLLIYAASTLQSG VPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPQTFGPGTKVDIKRFGGGTKVE IKGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGASVKVSCKASSYYIHMHWVRQAP GQGLEWMGRRINPKSGRTYYAQNFQGNYAQKFQGRVTSTRDTSISTAYMELSRLRS DDTVVYYCARLTEGIPDYWGQGTTVTVSS (SEQ ID NO: 937).

[00399] Sana CD8 scFv form 7

DIQMTQSPSSLSASVGDRVTITCRASQNIGTWLAWYQQKPGKAPKLLIYAASTLQSG VPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPQTFGPGTKVDIKRFGGGTKVE IKGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGASVKVSCKASSYYIHMHWVRQAP GQGLEWMGRRINPKSGRTYYAQNFQGNYAQKFQGRVTMTRDTSISTAYMELSRLRS DDTVVYYCARLTEGIPDYWGQGTTVTVSS (SEQ ID NO: 938).

[00400] Sana CD8 scFv form 8

DIQMTQSPSSLSASVGDRVTITCRASQNIGTWLAWYQQKPGKAPKLLIYAASTLQSG VPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPQTFGPGTKVDIKRFGGGTKVE IKGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVR QAPGQGLEWMGIRINPKSGRTYYAQNFQGSYAQKFQGRVTMTRDTSTSTVYMELSS

LRSEDTAVYYCARLTEGIPDYWGQGTTVTVSS (SEQ ID NO: 939).

[00401] Sana CD8 scFv form 9

DIQMTQSPSSLSASVGDRVTITCRASQNIGTWLAWYQQKPGKAPKLLIYAASTLQSG

VPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPQTFGPGTKVDIKRFGGGTKVE

IKGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVR QAPGQGLEWMGRINPKSGRTNYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTVVY YCARLTEGIPDYWGQGTTVTVSS (SEQ ID NO: 940).

[00402] Sana CD8 scFv form 10

DIQMTQSPSSLSASVGDRVTITCRASQNIGTWLAWYQQKPGKAPKLLIYAASTLQSG

VPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPQTFGPGTKVDIKRFGGGTKVE

IKGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVR QAPGQGLEWMGIINPKSGRTSYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVY YCARLTEGIPDYWGQGTTVTVSS (SEQ ID NO: 941).

[00403] Sana CD8 VHH form 1

QVQLVESGGGLVQPGGSLRLSCSASGYVMGMHWVRQAPGKGLEYVSAAISRGGLS TSYADSVKGYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCDRSDLYEIT AASNIDSWGQGTTVTVSS (SEQ ID NO: 942).

[00404] Sana CD8 VHH form 2

QVQLQQWGAGLLKPSETLSLTCAVYGRTFSGYVWSWIRQPPGKGLEWIGEISRGGLS TNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAADRSDLYEITAASNIDSW GQGTTVTVSS (SEQ ID NO: 943).

[00405] Sana CD8 VHH form 3

QVQLVESGGGLVQPGGSLRLSCSASGRTFSGYMHWVRQAPGKGLEYVSAVISRGGL STAAYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCDRSDLYEITAASNID SWGQGTTVTVSS (SEQ ID NO: 944).

[00406] CD117 scFv AHI: QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGQGLEWIGVIYSGN GDTSYNQKFKGKATLTADKSSSTAYMQINSLTSEDSAVYYCARERDTRFGNWGQGT LVTVSAGGGGSGGGGSGGGGSNIVLTQSPASLAVSLGLRATISCRASESVDIYGNSFM HWYQQKPGQPPKLLIYLASNLESGVPARFSGSGSRTDFTLTIDPVEADDAATYYCQQ NNEDPYTFGGGTKLEIK(SEQ ID NO: 504).

[00407] CD 117 scFv AH2:

NIVLTQSPASLAVSLGLRATISCRASESVDIYGNSFMHWYQQKPGQPPKLLIYLASNL ESGVPARFSGSGSRTDFTLTIDPVEADDAATYYCQQNNEDPYTFGGGTKLEIKGGGG SGGGGSGGGGSQVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGQ

GLEWIGVIYSGNGDTSYNQKFKGKATLTADKSSSTAYMQINSLTSEDSAVYYCARER DTRFGNWGQGTLVTVSA (SEQ ID NO: 505).

[00408] CD 117 scFv 2Dl:

DIVMTQSHKFMSTSVGDRVSITCKASQDVSTTVAWYQQKPGQSPKLLIYSASYRYTG VPDRFTGSGSGTDFTFTISSVQAEDLAVYYCQQHYSTPPTFGGGTKLEIKGGGGSGG GGSGGGGSQVQLQQSDAELVKPGASVKISCKASGYTFTDHAIHWVKQRPEQGLEWI GCISPGNGDIKYNEKFKGKATLSADKSSSTAYMQLNSLTSEDSAVYFCKRWDYFDY WGQGTTLTVSS (SEQ ID NO: 506).

[00409] CD 117 scFv 2D2:

QVQLQQSDAELVKPGASVKISCKASGYTFTDHAIHWVKQRPEQGLEWIGCISPGNGD

IKYNEKFKGKATLSADKSSSTAYMQLNSLTSEDSAVYFCKRWDYFDYWGQGTTLTV SSGGGGSGGGGSGGGGSDIVMTQSHKFMSTSVGDRVSITCKASQDVSTTVAWYQQK PGQSPKLLIYSASYRYTGVPDRFTGSGSGTDFTFTISSVQAEDLAVYYCQQHYSTPPT FGGGTKLEIK (SEQ ID NO: 507).

[00410] CD117 scFv 4Fl:

DIVMTQSHKFMSTSVGDRVSITCKASQDVSTTVAWYQQKPGQSPKLLIYSASYRYTG VPDRFTGSGSGTDFTFTISSVQAEDLAVYYCQQHYSTPPTFGGGTKLEIKGGGGSGG GGSGGGGSEVQLQESGPSLVKPSQTLSLTCSVTGDSITSGYWNWIRKFPGNKLEYMG

YINYSGSTYYNPSLKSQISITRDTSKNQYYLQLNSVTTEDAATYYCARGGNYFAMDY WGQGTSVTVSS (SEQ ID NO: 508). [00411] CD 117 scFv 4F2:

EVQLQESGPSLVKPSQTLSLTCSVTGDSITSGYWNWIRKFPGNKLEYMGYINYSGST

YYNPSLKSQISITRDTSKNQYYLQLNSVTTEDAATYYCARGGNYFAMDYWGQGTSV TVSSGGGGSGGGGSGGGGSDIVMTQSHKFMSTSVGDRVSITCKASQDVSTTVAWYQ QKPGQSPKLLIYSASYRYTGVPDRFTGSGSGTDFTFTISSVQAEDLAVYYCQQHYSTP PTFGGGTKLEIK (SEQ ID NO: 509).

[00412] CD 117 scFv 4k94:

EVQLVESGGGLVQPGGSLRLSCAASGFNISSYSMHWVRQAPGKGLEWVASIYPYSG

YTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARYVYHALDYWGQGT LVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWY QQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQWAVH SLITFGQGTKVEIK (SEQ ID NO: 510).

[00413] CD117 scFv 54:

QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGT ANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARGGLDTDEFDLWGRGT LVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSINSYLNWY

QQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGVSDI TFGGGTKVEIK (SEQ ID NO: 511).

[00414] CD117 scFv 55:

QVQLVQSGAEVKKPGSSVKVSCKASGGTFRIYAISWVRQAPGQGLEWMGGIIPDFG VANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARGGLDTDEFDLWGRG TLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSINSYLNW YQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGVS DITFGGGTKVEIK (SEQ ID NO: 512).

[00415] CD117 scFv 56:

QVQLVQSGAEVKKPGSSVKVSCKASGGTFSLYAISWVRQAPGQGLEWMGGIIPAFG TANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARGGLDTDEFDLWGRG TLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSINSYLNW YQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGVS

DITFGGGTKVEIK (SEQ ID NO: 513).

[00416] CD117 scFv 57:

QVQLVQSGAEVKKPGSSVKVSCKASGGTFSLYAISWVRQAPGQGLEWMGGIIPHFG LANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARGGLDTDEFDLWGRG TLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSINSYLNW YQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGVS DITFGGGTKVEIK (SEQ ID NO: 514).

[00417] CD117 scFv 58

EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYAMSWVRQAPGKGLEWVSAISGSGG STYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGPPTYHTNYYYMD VWGKGTTVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSVSASVGDRVTITCRASQGIS SWLAWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYC QQTNSFPYTFGGGTKVEIK (SEQ ID NO: 515).

[00418] CD117 scFv 61:

EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYVMIWVRQAPGKGLEWVSSISGDSVT TYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGPPTYHTNYYYMDV WGKGTTVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSVSASVGDRVTITCRASQGISS WLAWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQ QTNSFPYTFGGGTKVEIK (SEQ ID NO: 516).

[00419] CD117 scFv 66:

EVQLVESGGGLVQPGGSLRLSCAASGFTFSDHYMDWVRQAPGKGLEWVGRTRNKA SSYTTEYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCAREPKYWIDFDLW GRGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSISSYL NWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQS YIAPYTFGGGTKVEIK (SEQ ID NO: 517).

[00420] CD117 scFv 67: EVQLVESGGGLVQPGRSLRLSCTASGFTFSDHDMNWVRQAPGKGLEWVGRTRNAA GSYTTEYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCAREPKYWIDFDLW GRGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSISSYL NWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQS YIAPYTFGGGTKVEIK (SEQ ID NO: 518).

[00421] CD117 scFv 68:

EVQLVESGGGLVQPGRSLRLSCTASGFTFSDHDMNWVRQAPGKGLEWVGRTRNAA GSYTTEYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCAREPKYWIDFDLW GRGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSISSYL NWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQS YIAPYTFGGGTKVEIK (SEQ ID NO: 519).

[00422] CD117 scFv 69:

EVQLVESGGGLVQPGGSLRLSCAASGFTFVDHDMDWVRQAPGKGLEWVGRTRNKL GSYTTEYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCAREPKYWIDFDLW GRGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSISSYL NWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQS YIAPYTFGGGTKVEIK (SEQ ID NO: 520).

[00423] CD117 scFv 70:

EVQLVESGGGLVQPGGSLRLSCAASGFTFVDHDMDWVRQAPGKGLEWVGRTRNKL GSYTTEYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCAREPKYWIDFDLW GRGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSISSYL NWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQS YIAPYTFGGGTKVEIK (SEQ ID NO: 521).

[00424] CD 117 SRI scFv:

QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGQGLEWIGVIYSGN GDTSYNQKFKGKATLTADKSSSTAYMQINSLTSEDSAVYYCARERDTRFGNWGQGT LVTVSAAKTTGGGGSGGGGSGGGGSIVLTQSPASLAVSLGLRATISCRASESVDIYGN SFMHWYQQKPGQPPKLLIYLASNLESGVPARFSGSGSRTDFTLTIDPVEADDAATYY CQQNNEDPYTFGGGTKLEIK (SEQ ID NO: 522). [00425] CXCR4 scFv 1:

EVQLVESGGGLVQPGGSLRLSCAAAGFTFSSYSMNWVRQAPGKGLEWVSYISSRSR

TIYYADSVKGRFTISRDNAKNSLYLQMNSLRDEDTAVYYCARDYGGQPPYYYYYG MDVWGQGTTVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQ GISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFVTY YCQQYNSYPRTFGQGTKVEIK (SEQ ID NO: 527).

[00426] CXCR4 scFv 2:

DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGV PSRFSGSGSGTDFTLTISSLQPEDFVTYYCQQYNSYPRTFGQGTKVEIKGGGGSGGGG SGGGGSEVQLVESGGGLVQPGGSLRLSCAAAGFTFSSYSMNWVRQAPGKGLEWVS YISSRSRTIYYADSVKGRFTISRDNAKNSLYLQMNSLRDEDTAVYYCARDYGGQPPY YYYYGMDVWGQGTTVTVSS (SEQ ID NO: 528).

[00427] CD90 scFv 1:

QVQLLQPGAELVRPGASVRLSCKTSGYTFTSYWINWVKQRPGQGLEWIGKIFPSDSH TNYNQKFKDKATLTVDKSSSTAYMQLISPTSEDSAVYYCTRDFDTQFYAMEYWGQ GTSVTVSSGSDSNAGHASAGNTSQIVLTQSPTIMSASPGQKVTINCSAISSVNYMHWY QQKPGSSPKLWIYATSKLTLGVPARFSGSGSGTSYSLTVNSMVTEDATSYFCHQWSS YPPTFGAGTKLELK (SEQ ID NO: 529).

[00428] CD90 scFv 2:

QVQLLQPGAELVRPGASVRLSCKTSGYTFTSYWINWVKQRPGQGLEWIGKIFPSDSH

TNYNQKFKDKATLTVDKSSSTAYMQLISPTSEDSAVYYCTRDFDTQFYAMEYWGQ GTSVTVSSGGGGSGGGGSGGGGSDIQMTQTTSSLSASLGDRVTISCRASQDISNYLN WYQQKPDGTFKLLIYYTSRLHSGVPSRFSGGGSGTDYSLTISNLEKEDIATYFCQQGN TLPRTFGGGTRLEVK (SEQ ID NO: 530).

[00429] CD 133 scFv 1:

AEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISRTG

GVTRYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKRTRRFDYWCQGT LVTVSSSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYSASDLQSGVP

SRFSGSGSGTDFTLTISSLQPEDFATYYCQQTANSPSTFGQGTKVEI (SEQ ID NO: 531).

[00430] CD 133 scFv 2:

DIVLSQSPAIMSASPGEKVTISCSASSSVSYMYWYQQKPGSSPKPWIYRTSNLASGVP ARFSGSGSGTSYSLTISSMEAEDAATYYCQQYHSYPPTFGAGTKLELKSSGGGGSGG GGGGSSRSSLEVKLVESGPELKKPGETVKISCKASGYTFTDYSMKWVNQAPGKGLK WMGWINTETGEPSYADDFKGRFAFSLETSASTAYLQINNLKNEDTATYFCATDYGD YFDYWGQGTTLTVSS (SEQ ID NO: 532).

[00431] FLT3L:

DCSFQHSPISSDFAVKIRELSDYLLQDYPVTVASNLQDEELCGGLWRLVLAQRWMER LKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCLRFVQTNISRLLQETSEQLVALKP WITRQNFSRCLELQCAAAIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKP (SEQ ID NO: 533).

[00432] In some embodiments, the targeting domain comprises an amino acid sequence that is at least 80%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of any SEQ ID NO:s: 343-362, 387, 900-944, 504-522, or 527- 533.

[00433] In some embodiments, the targeting domain is selected from the group consisting of CALR-del52, CALR-ins5, CXCL12, AdF35, mSCF soluble, SCF, SCF mutant (V49L/F63L/K91E/I98R), SCF mutant (V49L/F63L/K91E), SCF mutant (V49L/F63L), SCF soluble, SCF soluble mutant (V49L/F63L/K91E/I98R), SCF soluble mutant (V49L/F63L/K91E), SCF soluble mutant (V49L/F63L), TPO-157, TPO-163, TPO-171, TPO, CXCL1 1, CXCL4, and CXCL14

Signaling peptides

[00434] In some embodiments, the eVLPs comprising a fusion protein may further comprise an optional signaling peptide. Any suitable signaling peptide known to one of ordinary skill in the art may be used to make the fusion proteins contemplated herein. Without wishing to be bound by any particular theory, it is believed that signaling peptides (also referred to as signal sequence, targeting signal, localization signal, localization sequence, transit peptide, leader sequence, or leader peptide) is a short peptide (e.g., typically between 16-30 amino acids long) present at the N-terminus (or occasionally non-classically at the C-terminus or internally within the peptide sequence) of most newly synthesized proteins that are destined toward the secretory pathway. Functionally, signaling peptides prompt a cell to translocate the protein to a desired location (e.g., to the cell membrane). In some embodiments, the signaling peptide is cleaved from the fusion protein following translocation; however, in other embodiments, the signaling peptide is not cleaved from the fusion protein following translocation.

[00435] VSVG:

MKCLLYLAFLFIGVNC (SEQ ID. NO. 6)

[00436] hCD4:

MNRGVPFRHLLLVLQLALLPAATQG (SEQ ID. NO. 7)

[00437] hCD45:

MYLWLKLLAFGFAFLDTEVFVTG (SEQ ID. NO. 8)

[00438] hCD8a:

MSLPVTALLLPLALLLHAARP (SEQ ID. NO. 9)

[00439] hCD8a-l

MALPVTALLLPLALLLHAARP (SEQ ID. NO. 10)

[00440] hCD8b:

MRPRLWLLLAAQLTVLHGNSV (SEQ ID. NO. 11)

[00441] hCD2:

MSFPCKFVASFLLIFNVSSKGAVS (SEQ ID. NO. 12)

[00442] hCD5:

MPMGSLQPLATLYLLGMLVASCLG (SEQ ID. NO. 13) [00443] hCD7:

MAGPPRLLLLPLLLALARGLPGALA (SEQ ID. NO. 14)

[00444] hTYRPl:

MSAPKLLSLGCIFFPLLLFQQARA (SEQ ID. NO. 15)

[00445] hLALBa:

MRFFVPLFLVGILFPAILA (SEQ ID. NO. 16)

[00446] hBGAL:

MPGFLVRILPLLLVLLLLGPTRG (SEQ ID. NO. 17)

[00447] hCD52:

MKRFLFLLLTISLLVMVQIQTGLS (SEQ ID. NO. 18)

[00448] hCD109:

MQGPPLLTAAHLLCVCTAALA (SEQ ID. NO. 19)

[00449] hCO3:

MGPTSGPSLLLLLLTHLPLALG (SEQ ID. NO. 20)

[00450] hGRAB:

MQPILLLLAFLLLPRADA (SEQ ID. NO. 21)

[00451] hKV310:

MEAPAQLLFLLLLWLPDTTR (SEQ ID. NO. 22)

[00452] hKV401:

MVLQTQVFISLLLWISGAYG (SEQ ID. NO. 23)

[00453] hLV605:

MAWAPLLLTLLAHCTDCWA (SEQ ID. NO. 24)

[00454] hIL2RG: MLKPSLPFTSLLFLQLPLLGVG (SEQ ID. NO. 25)

[00455] hBPILl:

MAWASRLGLLLALLLPVVGA (SEQ ID. NO. 26)

[00456] hFCGRN:

MGVPRPQPWALGLLLFLLPGSLG (SEQ ID. NO. 27)

[00457] mlgK:

MAVPTQVLGLLLLWLTOA (SEQ ID. NO. 28)

[00458] B2M signal peptide

MSRSVALAVLALLSLSGLEA (SEQ ID NO: 395

[00459] In some embodiments, the signaling peptide comprises an amino acid sequence that is at least 80%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of any SEQ ID NO:s: 6-28.

Fusion protein sequences

[00460] In some embodiments the fusion proteins comprise at least one of the following non-limiting structures:

(1) [Signaling peptide] -[TPO]- [optional linker] -[VS VGTM];

(2) [Signaling peptide]- [SCFK9iE^mono]- [optional linker] -[ VS VGmut];

(3) [Signaling peptide]- [ADF35]-[optional linker] -[VS VGTM];

(4) [Signaling peptide] -[SCF]- [optional linker] -[ VS VG];

(5) [Signaling peptide] -[SCF] -[optional linker] -[IgG4]- [optional linker] -[CD62];

(6) [Signaling peptide] -[SCF] -[optional linker] -[CD8]- [optional linker] -[CD43];

(7) [Signaling peptide] -[SCF] -[optional linker] -[CD8]- [optional linker]- [CD62];

(8) [Signaling peptide] -[SCF] -[optional linker] -[CD8]- [optional linker] -[HL A- A2];

(9) [Signaling peptide] -[SCF] -[optional linker] -[CD8]- [optional linker]-[HLA-DRA];

(10) [Signaling peptide] -[SCF] -[optional linker] -[CD8]- [optional linker] -[LFA-1].

(11) [TPO] -[optional linker] -[VS VGTM] ;

(12) [SCFK9iE^mono]- [optional linker] -[VS VGmut]; (13) [ADF35]-[optional linker] -[ VS VG™];

(14) [SCF]- [optional linker] -[ VS VG];

(15) [SCF] -[optional linker] -[IgG4]- [optional linker] -[CD62];

(16) [SCF] -[optional linker] -[CD8]- [optional linker] -[CD43];

(17) [SCF] -[optional linker] -[CD8]- [optional linker]- [CD62];

(18) [SCF] -[optional linker] -[CD8]- [optional linker] -[HLA-A2];

(19) [SCF] -[optional linker] -[CD8]- [optional linker]-[HLA-DRA];

(20) [SCF] -[optional linker] -[CD8]- [optional linker] -[LFA-1]

(21) [SCF(V49L/F63L)]- [optional linker] -[ VS VG™]

(22). [SCF (V49L/F63L/K91E)]-[optional linker] -[ VS VGMUT^ASP].

[00461] Construct 106

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCT

CTGCCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATT

CTTCGAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACT

CCAAACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTG

TGCATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAAC

AAGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCATGAAGTGCCTTTTGTACTTA

GCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCCACACAACCA

AAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCA

GATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCC

AGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGG

TCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCG

ATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACA

AGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTG

ACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATG

AATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATT

ACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAA

AGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGAC

GGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTT

GCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGA

GTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTG CAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGAC

CTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTC

TGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGAT

CTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCA

ATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCC

AATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACT

GTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCT

GAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTG

GACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTC

AAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGG

GCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAG

CTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCT

CCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATT

TATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAAATCCTGCACAACA

GATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCA

ATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAACGGAATTCCTC

GAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTG

GTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCT

CTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTA

ATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCAC

TCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGG

TTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCT

ATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCAT

AGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTT

TCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTC

TCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGG

ATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCG

CTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGT

GCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCC

AGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGA

(SEQ ID. NO. 89) [00462] Construct 113

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGAAGCCA

TCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCG

ACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTT

CGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTT

AGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTT

TCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGT

AACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGT

TTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGG

GTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATG

ATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATT

GGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAAT

GATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTC

TGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGG

TTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGA ATTCTGACACTATGACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTA

CCCCTACGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATC

AGCCCTAATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGA

CCCCTCTCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGA

CCGTGGACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTA

TCACCAAGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCC

AGAACAACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAG

ATATCTGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACC

TAATTGCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGT

GCTGGTTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCC

GATACAGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTG

TATTTCGACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCC

TGAAAAACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCT

TCATGCCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAA

CTACATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCC

CTGAACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTAC

GCCATCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATC

GCCACACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACA

GCGGTGGGAGCGGCGGGAGCGGCGGTAGCAAGTGCCTTTTGTACTTAGCCTTTTT

ATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGA

AACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAA

ATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCAAGAGTC

ACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTAC

TTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTC

ACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACT

TGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATG

CCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACAC

AGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATG

CCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTA

TGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGC

TATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATG

AAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGAC

TCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAG ATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTG

GATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAG

AAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTA

TCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCT

CAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAAGGGAACTGTGGGATG

ACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCA

GTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGA

TCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCT

GCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAA

AAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCC

TCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGT

ATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCA

TGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTT

GAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATC

CGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGT

GTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAA

ATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAA

ATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGA

CATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTT

GGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGG

TCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCC

TTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACAT

CCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTA

CTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCG

CAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAAT

TCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATG

AGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGA

AACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGA (SEQ ID.

NO. 90)

[00463] Construct 114

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGC

CAGGCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGC

AAGCTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGG TGCACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGA

GTGGAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGA

CCCTGCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCT

GTCCAGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCT

GCAGAGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAA

GGACCCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGG

TTTCTGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCA

CCGCCGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAG

AACGAGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTC

TGGTCTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAA

CCAGACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGA

GCTGCTGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGG

AGCTCCTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCT

GCAACCTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTG

TTTCCTCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCC

TGACCCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTAC

ACACACAGCCAGAACCTGTCTCAGGAGGGCAGCGGTGGGAGCGGCGGGAGCGG

CGGTAGCATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCA

AGTTCACCATAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTC

TAATTACCATTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATA

GGCACAGCCTTACAAGTCAAAATGCCCAAGAGTCACAAGGCTATTCAAGCAGAC

GGTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATG

GACCGAAGTATATAACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATG

CAAGGAAAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCC

TCCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAG

GTGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCAC

AGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTAC

AACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCC

ATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAG

GGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGC

AAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTC

GAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAG

GGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGA CGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAG

AGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCA

GGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCA

GATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGAT

CAGTGGAACTACCACAGAAAGGGAACTGTGGGATGACTGGGCACCATATGAAGA

CGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCT

TTATACATGATTGGACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGG

CTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGA

TGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTA

GAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGG

GTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAAT

TAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTG

GAAAGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTT

GTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAA

AAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCA

GGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCA

CAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAG

CCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGT

GTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCAT

TTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGC

TGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGC

CCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTT

TTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACAT

GTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCC

TCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATA

GCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCC

GGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTA

ATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGC

ATTAATGAATCGGCCAACGCGCGGGGA (SEQ ID. NO. 91)

[00464] Construct 115

TCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTG

GAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAG

TTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCA

GCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATA

AGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAA

GCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAA

AAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATT

GTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATT

TTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGAC

CGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAAC

GTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTA

CGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAA

ATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGA

ACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTG

GCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCG CCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGG

CGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCT

GCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAA

ACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTC

CACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCAT

ATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACAT

TGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCC

CATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACC

GCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACG

CCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCC

ACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAA

TGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTT

CCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGT

TTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAG

TCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGAC

TTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTG

TACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTG

GAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAG

CCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGT

TCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAG

GGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAA

TTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTT

CATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAAT

TCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAG

GCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTAT

AATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAAT

ATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATG

GTTACAATGATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCG

GGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAA

CGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCC

TCGAGGAATTCTGACACTATGAAAAAAACCCAGACCTGGATCCTGACATGCATC

TACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAA

ATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCA AGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCC

ACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCT

GGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAA

GCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAA

GGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGA

ATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCC

TCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCA

GAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAG

AAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCA

GCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTT

CGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGT

GGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGA

AGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGC

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCAC

CATAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTAC

CATTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAG

CCTTACAAGTCAAAATGCCCAAGAGTCACAAGGCTATTCAAGCAGACGGTTGGA

TGTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAA

GTATATAACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAA

AGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAA

AGTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACT

CCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCA

TCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTG

GCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGAC

ATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCCGGGAAAGGAGGGCACA

GGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATG

CAATACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATG

GCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAA

GTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGA

GAGGATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGG

TCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACC

GGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACA

TCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGG AACTACCACAGAAAGGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGA

AATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATAC

ATGATTGGACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGG

TGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAG

TTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGT

TGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAAT

CATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGC

ACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGT

AACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATA

CCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAA

AAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGC

AGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCCGGCTCACAAAT

ACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCT

TGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTT

GGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAA

ACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCT

GCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCT

GCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTAT

ATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTT

ACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTC

TCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGT

TTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAG

CATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGC

GTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAA

TGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTT

CCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGC

TCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAA

GAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGT

TGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACG

CTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCC

CCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATAC

CTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAG

GTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCC CCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACC

CGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCA

GAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACG

GCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTT

CGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGG

TGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAA

GATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTT

AAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAA

TTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGAC

AGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTC

ATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTA

CCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAG

ATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTG

CAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAG

TAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTG

GTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAA

GGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCC

TCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCA

GCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGG

TGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCT

TGCCCGGCG (SEQ ID. NO. 92)

[00465] Construct 117

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGAAGCCA

TCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCG

ACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTT

CGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTT

AGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTT

TCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGT

AACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGT

TTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGG

GTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATG

ATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATT

GGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAAT

GATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTC

TGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGG

TTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGA

ATTCTGACACTATGAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCA

ACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTG

ACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTAC

ATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGA

TCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTT

CAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAA

CATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAA

AAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGA

ATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACAT

CTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGT

GACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGC

AGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGG

GCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCG

CTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCC

AGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAA

TTTCAGGAGGTGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAA

TCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTT

TATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCA CTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCT

GGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATC

ATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTG

CAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGC

AAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCC

CATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATG

AAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTT

AGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTC

CTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAG

CTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCAT

GTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATA

CGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTC

ACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCC

AGCTGCATTAATGAATCGGCCAACGCGCGGGGA (SEQ ID. NO. 93)

[00466] Construct 130

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCT

GCACGCCGCTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCT

CCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGG

GTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGAC

TACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTT

GGATCAGCGAGATGCTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACA

AGCTGAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGG

TCAACATCGTGGACGACCTGGTTGAGTGCGTGGAGGAGAACAGCTCCAAGGACC

TGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTT

CAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAG

ACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTG

TCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACG

ACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGC

ACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTC

GGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAAC

ATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACG

GGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATGAAGT GCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTT

TTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATT

GCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACA

AGTCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCA

TGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATA

ACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTG

AACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTG

GATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACC

ATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGG

AAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCT

GACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCT

TCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCA

GAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACT

GCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATA

AGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTC

TGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATC

TTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAA

TCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGC

TTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTC

GATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCA

CAGAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGAC

CCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGG

ACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAA

CATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTT

TGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGT

AGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACT

ATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAG

AAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAAA

TCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTC

AAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAA

ACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCT

ATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAG

ATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCT GACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTT

TGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGA

ATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAA

CAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCAT

TCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTT

GTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGA

TTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAG

ATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTG

AAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTG

TAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCA

CTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCC

AACGCGCGGGGA (SEQ ID. NO. 94)

[00467] Construct 131

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCT

GCACGCCGCTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCT

CCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGG

GTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGAC

TACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTT

GGATCAGCGAGATGCTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACA

AGCTGAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGG

TCAACATCGTGGACGACCTGGTTGAGTGCGTGGAGGAGAACAGCTCCAAGGACC

GGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTT

CAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAG

ACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTG

TCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACG

ACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGC

ACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTC

GGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAAC

ATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACG

GGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATGAAGT

GCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTT

TTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATT GCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACA

AGTCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCA

TGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATA

ACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTG

AACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTG

GATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACC

ATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGG

AAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCT

GACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCT

TCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCA

GAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACT

GCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATA

AGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTC

TGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATC

TTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAA

TCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGC

TTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTC

GATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCA

CAGAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGAC

CCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGG

ACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAA

CATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTT

TGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGT

AGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACT

ATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAG

AAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAAA

TCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTC

AAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAA

ACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCT

ATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAG

ATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCT

GACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTT

TGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGA ATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAA

CAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCAT

TCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTT

GTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGA

TTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAG

ATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTG

AAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTG

TAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCA

CTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCC

AACGCGCGGGGA (SEQ ID. NO. 95)

[00468] Construct 132

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACG

TGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACG

TGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGC

AGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGG

CCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTT

GAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCC

GAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCG

ACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAG

CACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTG

CCTCCTGTGGCCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATGAAGTGC

CTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTT

TCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGC

CCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAG

TCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATG

CTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAAC

ACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAA

CAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGA

TATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATG

TGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAA AATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGA

CTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTC

TTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGA

AGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGC

AAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAG

GATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTG

CTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTT

GGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATC

TCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTT

TCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGA

TATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACA

GAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCC

AATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGAC

ATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACA

TCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTG

GTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAG

TTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTAT

TCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAA

AAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAAATC

CTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAA

AGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAAC

GGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTAT

CAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGAT

_{CTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGA}

CTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTG

TGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAAT

GAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACA

AAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTC

CTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGT

GTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATT

TTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGAT

CCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAA

ATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTA AAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACT

GCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAA

CGCGCGGGGA (SEQ ID. NO. 96)

[00469] Construct 133

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCT

GCACGCCGCTAGACCTGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAA

GGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAA

GTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGT

GGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCT

GAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGAC

CTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAG

AGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGA

GTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGT

CAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATT

CATGCTGCCTCCTGTGGCCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCAT

GAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCA

TAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCA

TTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCC

TTACAAGTCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATG

TGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGT

ATATAACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAG

CATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAG

TTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCT

CACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCA

ACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCA

TTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATC ACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGG

TTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAA

TACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTG

ATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTAT

CTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGG

ATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTC

CAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCC

TGCTTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGA

GTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTA

CCACAGAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTG

GACCCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGAT

TGGACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTC

GAACATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTAT

TTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTT

CAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTG

GACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACC

AAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTC

AAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATG

CTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAA

AAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCT

GCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACT

GAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCA

TCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATT

TTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCA

GAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATG

AACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTC

CATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTG

TTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGC

CAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATG

GAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGT

GTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAA

GTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGC TCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCG

GCCAACGCGCGGGGA (SEQ ID. NO. 97)

[00470] Construct 134

TCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTG

GAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAG

TTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCA

GCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATA

AGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAA

GCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAA

AAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATT

GTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATT TTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGAC

CGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAAC

GTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTA

CGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAA

ATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGA

ACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTG

GCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCG

CCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGG

CGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCT

GCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAA

ACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTC

CACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCAT

ATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACAT

TGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCC

CATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACC

GCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACG

CCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCC

ACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAA

TGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTT

CCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGT

TTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAG

TCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGAC

TTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTG

TACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTG

GAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAG

CCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGT

TCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAG

GGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAA

TTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTT

CATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAAT

TCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAG

GCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTAT

AATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAAT ATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATG

GTTACAATGATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCG

GGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAA

CGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCC

TCGAGGAATTCTGACACTATGAAAAAAACCCAGACCTGGATCCTGACATGCATC

TACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAA

ATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCA

AGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCC

ACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCT

GGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAA

GCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAA

GGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGA

ATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCC

TCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCA

GAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAG

AAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCA

GCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTT

CGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGT

GGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGA

AGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGC

GGCATGCTGCCTGTGGCTGTGCTGGTGGCCCTGCTCGCCGTGATCGTGCTGGTCG

CCCTGCTGCTGCTGTGGCGGAGAAGACAGAAGAGACGGACCTAACTCAAATCCT

GCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAG

AGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAACGG

AATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCA

GAAGGTGGTGGCTGGTGTGGCCAATGCCCCGGCTCACAAATACCACTGAGATCT

TTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACT

TCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTG

TCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGA

GTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAA

GGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCT

TATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTG

TTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTT TTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATC

CCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAA

TTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAA

AGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTG

CCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAAC

GCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGA

CTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCG

GTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCA

AAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTC

CATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGG

TGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCC

CTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCT

CCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCG

GTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCG

ACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGA

CTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGT

AGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAG

AACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTT

GGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTT

GCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCT

TTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGT

CATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGT

TTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCT

TAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCC

TGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCA

GTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAAT

AAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGC

CTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTT

AATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGT

CGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATG

ATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTC

AGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATT

CTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACC AAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCG (SEQ

ID. NO. 98)

[00471] Construct 136

TCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTG

GAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAG

TTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCA

GCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATA

AGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAA

GCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAA

AAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATT

GTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATT TTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGAC

CGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAAC

GTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTA

CGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAA

ATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGA

ACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTG

GCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCG

CCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGG

CGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCT

GCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAA

ACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTC

CACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCAT

ATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACAT

TGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCC

CATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACC

GCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACG

CCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCC

ACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAA

TGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTT

CCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGT

TTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAG

TCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGAC

TTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTG

TACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTG

GAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAG

CCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGT

TCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAG

GGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAA

TTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTT

CATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAAT

TCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAG

GCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTAT

AATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAAT ATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATG

GTTACAATGATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCG

GGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAA

CGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCC

TCGAGGAATTCTGACACTATGAAAAAAACCCAGACCTGGATCCTGACATGCATC

TACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAA

ATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCA

AGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCC

ACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCT

GGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAA

GCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAA

GGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGA

ATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCC

TCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCA

GAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAG

AAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCA

GCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTT

CGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGT

GGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGA

AGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGC

ATCGTGATCATCTCTAGCAGCCTGCTGCTGGGCCTGATCGTGCTGCTGCTGATCA

GCTACGTGATGTGGAAGGCCGGCTTCTTCAAAAGACAGTACAAGTCCTAACTCA

AATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGC

TCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAA

AAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTG

CCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCCGGCTCACAAATACCACT

GAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCA

TCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATT

TTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCA

GAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATG

AACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTC

CATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTG

TTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGC CAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATG

GAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGT

GTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAA

GTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGC

TCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCG

GCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCT

CACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCA

AAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACAT

GTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGG

CGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAG

TCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGG

AAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCG

CCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTC

AGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTC

AGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAG

ACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAG

GTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACT

AGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAA

GAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTT

TGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTT

GATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATT

TTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAAT

GAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCA

ATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAG

TTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGG

CCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCA

GCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTA

TCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGC

CAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACG

CTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTT

ACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCG

TTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCA

TAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACT CAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGC

G (SEQ ID. NO. 99)

[00472] Construct 138

TCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTG

GAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAG

TTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCA

GCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATA

AGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAA

GCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAA

AAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATT

GTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATT TTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGAC

CGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAAC

GTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTA

CGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAA

ATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGA

ACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTG

GCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCG

CCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGG

CGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCT

GCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAA

ACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTC

CACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCAT

ATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACAT

TGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCC

CATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACC

GCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACG

CCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCC

ACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAA

TGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTT

CCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGT

TTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAG

TCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGAC

TTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTG

TACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTG

GAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAG

CCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGT

TCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAG

GGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAA

TTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTT

CATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAAT

TCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAG

GCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTAT

AATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAAT ATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATG

GTTACAATGATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCG

GGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAA

CGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCC

TCGAGGAATTCTGACACTATGAAAAAAACCCAGACCTGGATCCTGACATGCATC

TACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAA

ATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCA

AGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCC

ACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCT

GGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAA

GCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAA

GGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGA

ATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCC

TCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCA

GAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAG

AAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCA

GCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTT

CGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGT

GGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGA

AGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGC

CCTCTGTTCATCCCCGTGGCCGTGATGGTGACCGCCTTCAGCGGCCTGGCTTTTAT

CATCTGGCTGGCCAGAAGACTGAAGAAGGGCAAGAAATCTAAGCGGTAACTCAA

ATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCT

CAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAA

AACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGC

CTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCCGGCTCACAAATACCACTG

AGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCAT

CTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTT

TTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAG

AATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGA

ACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCC

ATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGT

TTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCC AGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATG

GAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGT

GTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAA

GTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGC

TCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCG

GCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCT

CACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCA

AAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACAT

GTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGG

CGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAG

TCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGG

AAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCG

CCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTC

AGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTC

AGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAG

ACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAG

GTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACT

AGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAA

GAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTT

TGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTT

GATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATT

TTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAAT

GAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCA

ATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAG

TTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGG

CCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCA

GCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTA

TCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGC

CAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACG

CTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTT

ACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCG

TTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCA

TAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACT CAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGC

G (SEQ ID. NO. 100)

[00473] Construct 140

TCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTG

GAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAG

TTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCA

GCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATA

AGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAA

GCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAA

AAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATT GTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATT

TTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGAC

CGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAAC

GTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTA

CGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAA

ATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGA

ACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTG

GCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCG

CCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGG

CGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCT

GCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAA

ACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTC

CACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCAT

ATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACAT

TGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCC

CATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACC

GCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACG

CCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCC

ACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAA

TGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTT

CCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGT

TTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAG

TCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGAC

TTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTG

TACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTG

GAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAG

CCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGT

TCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAG

GGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAA

TTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTT

CATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAAT

TCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAG

GCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTAT AATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAAT

ATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATG

GTTACAATGATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCG

GGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAA

CGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCC

TCGAGGAATTCTGACACTATGAAAAAAACCCAGACCTGGATCCTGACATGCATC

TACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAA

ATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCA

AGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCC

ACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCT

GGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAA

GCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAA

GGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGA

ATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCC

TCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCA

GAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAG

AAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCA

GCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTT

CGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGT

GGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGA

AGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGC

CTGCTGGCTATCCTGATCCTGGCCCTGGTCGCCACAATCTTCTTCGTGTGCACCGT

GGTGCTGGCCGTGAGACTGAGCAGAAAGGGCCACATGTACCCTGTGCGGAACTA

ACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATAC

CATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAA

AAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCA

GGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCCGGCTCACAAATA

CCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTT

GAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTT

GGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAA

ACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCT

GCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCT

GCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTAT ATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTT

ACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTC

TCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGT

TTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAG

CATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGC

GTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAA

TGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTT

CCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGC

TCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAA

GAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGT

TGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACG

CTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCC

CCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATAC

CTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAG

GTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCC

CCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACC

CGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCA

GAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACG

GCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTT

CGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGG

TGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAA

GATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTT

AAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAA

TTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGAC

AGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTC

ATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTA

CCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAG

ATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTG

CAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAG

TAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTG

GTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAA

GGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCC

TCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCA GCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGG

TGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCT

TGCCCGGCG (SEQ ID NO: 101)

[00474] Construct 142

TCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTG

GAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAG

TTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCA

GCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATA

AGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAA

GCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAA

AAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATT GTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATT

TTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGAC

CGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAAC

GTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTA

CGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAA

ATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGA

ACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTG

GCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCG

CCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGG

CGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCT

GCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAA

ACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTC

CACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCAT

ATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACAT

TGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCC

CATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACC

GCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACG

CCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCC

ACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAA

TGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTT

CCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGT

TTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAG

TCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGAC

TTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTG

TACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTG

GAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAG

CCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGT

TCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAG

GGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAA

TTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTT

CATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAAT

TCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAG

GCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTAT AATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAAT

ATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATG

GTTACAATGATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCG

GGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAA

CGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCC

TCGAGGAATTCTGACACTATGAAAAAAACCCAGACCTGGATCCTGACATGCATC

TACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAA

ATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCA

AGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCC

ACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCT

GGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAA

GCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAA

GGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGA

ATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCC

TCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCA

GAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAG

AAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCA

GCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTT

CGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGT

GGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGA

AGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGC

ATCGTGGGCATCATCGCCGGACTGGTGCTGTTCGGCGCCGTCATCACCGGCGCTG

TGGTGGCCGCCGTGATGTGGCGGAGAAAGTCTAGCGACAGAAAGGGCTAACTCA

AATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGC

TCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAA

AAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTG

CCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCCGGCTCACAAATACCACT

GAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCA

TCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATT

TTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCA

GAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATG

AACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTC

CATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTG TTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGC

CAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATG

GAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGT

GTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAA

GTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGC

TCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCG

GCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCT

CACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCA

AAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACAT

GTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGG

CGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAG

TCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGG

AAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCG

CCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTC

AGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTC

AGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAG

ACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAG

GTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACT

AGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAA

GAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTT

TGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTT

GATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATT

TTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAAT

GAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCA

ATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAG

TTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGG

CCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCA

GCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTA

TCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGC

CAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACG

CTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTT

ACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCG

TTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCA TAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACT

CAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGC

G (SEQ ID NO: 102)

[00475] Construct 144

TCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTG

GAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAG

TTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCA

GCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATA

AGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAA

GCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAA AAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATT

GTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATT

TTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGAC

CGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAAC

GTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTA

CGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAA

ATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGA

ACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTG

GCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCG

CCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGG

CGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCT

GCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAA

ACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTC

CACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCAT

ATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACAT

TGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCC

CATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACC

GCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACG

CCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCC

ACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAA

TGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTT

CCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGT

TTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAG

TCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGAC

TTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTG

TACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTG

GAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAG

CCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGT

TCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAG

GGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAA

TTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTT

CATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAAT

TCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAG GCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTAT

AATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAAT

ATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATG

GTTACAATGATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCG

GGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAA

CGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCC

TCGAGGAATTCTGACACTATGAAAAAAACCCAGACCTGGATCCTGACATGCATC

TACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAA

ATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCA

AGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCC

ACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCT

GGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAA

GCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAA

GGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGA

ATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCC

TCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCA

GAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAG

AAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCA

GCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTT

CGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGT

GGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGA

AGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGC

AACGTGGTGTGCGCCCTGGGCCTGACCGTGGGCCTGGTCGGCATCATCATTGGAA

CAATCTTCATCATCAAGGGCCTGAGAAAGAGCAACGCCGCTGAGCGGAGAGGCC

CTCTGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTT

GTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAA

AAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCA

GGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCCGGCTCA

CAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAG

CCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGT

GTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCAT

TTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGC

TGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGC CCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTT

TTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACAT

GTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCC

TCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATA

GCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCC

GGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTA

ATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGC

ATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTT

CCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGT

ATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGC

AGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGG

CCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAA

TCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGC

GTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCG

GATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGC

TGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACG

AACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTC

CAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGAT

TAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAA

CTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTT

ACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGT

AGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTC

AAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTC

ACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTT

TTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGT

CTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATT

TCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAG

GGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGG

CTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTG

GTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAG

AGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGC

ATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACG

ATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTC GGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTA

TGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTG

ACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTT

GCTCTTGCCCGGCG (SEQ ID NO: 103)

[00476] Construct 146

TCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTG

GAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAG

TTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCA

GCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATA

AGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAA GCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAA

AAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATT

GTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATT

TTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGAC

CGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAAC

GTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTA

CGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAA

ATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGA

ACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTG

GCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCG

CCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGG

CGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCT

GCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAA

ACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTC

CACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCAT

ATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACAT

TGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCC

CATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACC

GCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACG

CCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCC

ACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAA

TGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTT

CCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGT

TTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAG

TCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGAC

TTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTG

TACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTG

GAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAG

CCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGT

TCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAG

GGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAA

TTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTT

CATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAAT TCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAG

GCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTAT

AATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAAT

ATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATG

GTTACAATGATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCG

GGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAA

CGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCC

TCGAGGAATTCTGACACTATGAAAAAAACCCAGACCTGGATCCTGACATGCATC

TACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAA

ATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCA

AGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCC

ACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCT

GGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAA

GCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAA

GGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGA

ATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCC

TCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCA

GAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAG

AAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCA

GCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTT

CGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGT

GGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGA

AGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGC

ATCGTGATCATCACCGTGGTCGCCGCCGCTGTGATCATGGGCACAGCCGGCCTGA

GCACCTACCTGTACAACAGACAGAGAAAGATCAAGAAATACCGGCTGTAACTCA

AATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGC

TCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAA

AAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTG

CCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCCGGCTCACAAATACCACT

GAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCA

TCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATT

TTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCA

GAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATG AACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTC

CATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTG

TTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGC

CAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATG

GAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGT

GTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAA

GTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGC

TCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCG

GCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCT

CACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCA

AAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACAT

GTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGG

CGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAG

TCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGG

AAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCG

CCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTC

AGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTC

AGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAG

ACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAG

GTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACT

AGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAA

GAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTT

TGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTT

GATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATT

TTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAAT

GAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCA

ATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAG

TTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGG

CCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCA

GCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTA

TCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGC

CAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACG

CTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTT ACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCG

TTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCA

TAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACT

CAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGC

G (SEQ ID NO: 104)

[00477] Construct 148

TCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTG

GAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAG

TTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCA

GCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATA AGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAA

GCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAA

AAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATT

GTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATT

TTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGAC

CGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAAC

GTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTA

CGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAA

ATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGA

ACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTG

GCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCG

CCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGG

CGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCT

GCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAA

ACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTC

CACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCAT

ATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACAT

TGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCC

CATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACC

GCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACG

CCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCC

ACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAA

TGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTT

CCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGT

TTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAG

TCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGAC

TTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTG

TACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTG

GAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAG

CCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGT

TCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAG

GGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAA

TTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTT CATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAAT

TCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAG

GCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTAT

AATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAAT

ATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATG

GTTACAATGATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCG

GGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAA

CGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCC

TCGAGGAATTCTGACACTATGAAAAAAACCCAGACCTGGATCCTGACATGCATC

TACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAA

ATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCA

AGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCC

ACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCT

GGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAA

GCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAA

GGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGA

ATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCC

TCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCA

GAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAG

AAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCA

GCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTT

CGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGT

GGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGA

AGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGC

TACCTGTACGTGCTGAGCGGCATCGGCGGACTGCTGCTGCTGCTCCTGATCTTCA

TCGTGCTGTACAAGGTGGGCTTTTTCAAAAGAAACCTGAAGTAACTCAAATCCTG

CACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGA

GGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAACGGA

ATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAG

AAGGTGGTGGCTGGTGTGGCCAATGCCCCGGCTCACAAATACCACTGAGATCTTT

TTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTC

TGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTC

TCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGT ATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGG

TTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTA

TTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTT

_{ATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTT}

CCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCC

TCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATT

GTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAG

CCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCC

CGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGC

GCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACT

CGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGT

AATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAA

AAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCC

ATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGT

GGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCC

TCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTC

CCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGG

TGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGA

CCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGAC

TTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTA

GGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGA

ACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTG

GTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTG

CAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTT

TTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTC

ATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTT

TTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTT

AATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCT

GACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAG

TGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATA

AACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCC

TCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTA

ATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTC GTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGA

TCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCA

GAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTC

TCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCA

AGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCG (SEQ

ID NO: 105)

[00478] Construct 153

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACT

GCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACC

AACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATG

ATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCA

GCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCA

GCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACA

TCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAA

AGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAAT

CTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCT

GATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTG

ACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCA

GCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGG

CCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCT

CTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAG

ATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATT

TCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATGAAGTGCCTTTT

GTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCCAC

ACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTC

AAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAA

AATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCC

AAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATT

CCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAA

CGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGC AACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTG

GTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGC

AGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATA

AGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTC

AGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTA

ACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGC

ATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCT

CTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCA

TCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATT

ATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCC

AGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACC

ATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTG

CTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAG

CGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATG

GAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGG

TATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCT

CACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGA

TACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGG

AAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTT

GGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGA

CAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAAATCCTGC

ACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAG

GCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAACGGAA

TTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGA

AGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTT

TCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCT

GGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCT

CTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTA

TTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGT

TGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTAT

TCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTA

_{TTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTC}

CTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCT CGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTG

TTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGC

CTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCC

GCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCG

CGGGGA (SEQ ID NO: 106)

[00479] Construct 154

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGAACGCCAAGGTCGTGGT

CGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCAGCGACGGGAAGCCCGTCAGC

CTGAGCTACAGATGCCCATGCCGATTCTTCGAAAGCCATGTTGCCAGAGCCAACG

TCAAGCATCTCAAAATTCTCAACACTCCAAACTGTGCCCTTCAGATTGTAGCCCG

GCTGAAGAACAACAACAGACAAGTGTGCATTGACCCGAAGCTAAAGTGGATTCA

GGAGTACCTGGAGAAAGCTTTAAACAAGAGCGGTGGGAGCGGTGGGAGCATTGC

CTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGG

TATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCA

TGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTT

GAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCC

GTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGT

GTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAA

ATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAA ATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGA

CATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTT

GGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGG

TCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCC

TTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACAT

CCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTA

CTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCG

CAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAAT

TCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATG

AGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGA

AACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGT

TTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGT

TCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCAC

AGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGG

CCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCC

TGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGG

ACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTT

CCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGG

CGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCC

AAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCG

GTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGC

AGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTT

CTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGC

GCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCA

AACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCG

CAGAAAAAAAGGATCTCAA (SEQ ID NO: 107)

[00480] Construct 155

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGACCAAAAGAGTGCGGCT

GTCTGATAGCTTCAATCCTGTGTACCCCTACGAGGACGAGAGCACCTCCCAGCAC

CCCTTCTACAACCCCGGCTTCATCAGCCCTAATGGCTTTACCCAAAGCCCAGATG

GCGTGCTGACCCTGAAGTGCCTGACCCCTCTCACCACCACAGGCGGCTCCCTGCA

ACTGAAGGTGGGCGGAGGACTGACCGTGGACGACACCGACGGCACACTGCAGG

AGAACATCAGAGCCACCGCCCCTATCACCAAGAACAACCACAGCGTGGAACTGA

GCATCGGCAACGGCCTGGAAACCCAGAACAACAAGCTGTGCGCCAAGCTGGGCA

ATGGCCTGAAGTTCAACAACGGAGATATCTGTATCAAGGACTCTATCAACACCCT

GTGGACCGGAATCAACCCTCCACCTAATTGCCAGATCGTGGAAAACACCAATAC

CAACGACGGCAAGCTGACACTCGTGCTGGTTAAGAACGGAGGCCTGGTCAACGG

CTACGTGTCCCTGGTCGGCGTGTCCGATACAGTGAACCAGATGTTCACACAGAAG

ACCGCTAATATTCAGCTGAGACTGTATTTCGACTCCAGTGGCAACCTGCTGACAG

AGGAATCTGACCTGAAAATCCCCCTGAAAAACAAGAGCAGCACCGCCACATCTG

AGACAGTGGCCAGCAGCAAGGCCTTCATGCCTAGCACCACAGCTTATCCTTTTAA

CACCACCACACGGGACAGCGAGAACTACATCCACGGCATCTGCTACTACATGAC

CAGCTACGACAGAAGCCTGTTCCCCCTGAACATTAGCATCATGCTGAACAGCAG

GATGATCAGCAGCAACGTGGCTTACGCCATCCAGTTCGAGTGGAACCTGAACGC

CAGCGAGAGCCCTGAGTCTAATATCGCCACACTGACCACATCTCCTTTTTTCTTC

AGCTACATCACCGAAGATGACAACAGCGGTGGGAGCGGTGGGAGCATTGCCTCT

TTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTAT

CCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACAT

AGAGATGAACCGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCATG

TTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGA

_{GTTTTTAATTTTTATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGT}

CGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGT

GGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAAT TATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAAT

TTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACA

TATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGG

CAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTC

ATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTT

GACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATC

CCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACT

CCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCA

ATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTC

CACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAG

TGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAA

CCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTT

GCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTC

GGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAG

AATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCC

AGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTG

ACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGA

CTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTC

CGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGC

GCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCA

AGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGG

TAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCA

GCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTC

TTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCG

CTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAA

ACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGC

AGAAAAAAAGGATCTCAA (SEQ ID NO: 108)

[00481] Construct 156

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGAACTTACAGAACTGCT

GCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGGCTCCT

CCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACGTGCTG

CACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGTGCTGCT

CCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGAGACAAA

GGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGATGGCCGC

TCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTGAGTGG

ACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAACTCCC

ACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTGAGCTT

CCAGCACCTGCTGCGGGGCAAGGTGCGGTTTCTGATGCTGGTGGGCGGCTCCACC

CTGTGCGTGCGGAGAGCCCCTCCTACCACCGCCGTGCCCAGCCGGACATCTCTGG

TTCTCACCCTGAACGAGCTGCCTAATAGAACGAGCGGCCTGCTGGAAACCAACTT

CACCGCCAGCGCCAGAACCACAGGCTCTGGTCTGCTGAAATGGCAGCAGGGCTT

CAGAGCTAAAATCCCCGGCCTGCTGAACCAGACATCTAGAAGCCTTGATCAGAT

CCCTGGCTACCTGAACAGAATCCACGAGCTGCTGAACGGCACCAGAGGCCTCTT

CCCCGGACCCTCTAGAAGAACCCTGGGAGCTCCTGATATCAGCAGCGGCACAAG

CGACACCGGCAGCCTGCCACCTAACCTGCAACCTGGATATAGCCCCAGCCCCACT

CACCCCCCCACAGGCCAGTACACCCTGTTTCCTCTGCCTCCTACACTGCCAACAC

CCGTGGTCCAGCTGCACCCCCTGCTGCCTGACCCTAGCGCCCCTACCCCAACCCC

CACCTCTCCTCTGCTGAATACCAGCTACACACACAGCCAGAACCTGTCTCAGGAG

GGCAGCGGTGGGAGCGGTGGGAGCATTGCCTCTTTTTTCTTTATCATAGGGTTAA

TCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAG

CACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG

TAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGAT

ACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAA AAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGC

AGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAAT

ACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCT

TGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTT

GGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAA

ACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCT

GCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCT

GCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTAT

ATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTT

ACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTC

TCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGT

TTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAG

CATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGC

GTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAA

TGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTT

CCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGC

TCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAA

GAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGT

TGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACG

CTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCC

CCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATAC

CTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAG

GTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCC

CCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACC

CGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCA

GAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACG

GCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTT

CGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGG

TGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA

(SEQ ID NO: 109)

[00482] Construct 157

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAAAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGAAAAAAACCCAGACCT

GGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGAC

CGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCT

GGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATG

GACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGAT

TCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATT

ACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGA

AAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGAC

TGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAA

GGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCC

CCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGG

CCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACC

CCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAG

CCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGC

CTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGC

ATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGG

GAGCGGTGGGAGCATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTAT

TCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAA

AAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAAATC

CTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAA

AGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAAC

GGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTAT CAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGAT

_{CTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGA}

CTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTG

TGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAAT

GAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACA

AAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTC

CTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGT

GTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATT

TTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGAT

CCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAA

ATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTA

AAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACT

GCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAA

CGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTG

ACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGC

GGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGC

AAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTT

CCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAG

GTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTC

CCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTC

TCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTC

GGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCC

GACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACG

ACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATG

TAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAA

GAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGT

TGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTT

TGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA (SEQ ID NO: 110)

[00483] Construct 158

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGATGAAGTGCCTTTTGTA

CTTAGCCTTTTTATTCATTGGGGTGAATTGCAAAAAAACCCAGACCTGGATCCTG

ACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCA

TCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTA

ATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCT

GCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGAC

AGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATC

ATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAAC

AGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACC

CCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCG

TGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAA

GGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGC

TCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGA

GATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCA

TCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAG

GGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCA

GGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTG

GGAGCATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTT

CTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAG

ATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAAATCCTGCACA

ACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCC

TCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAACGGAATTCC

TCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGG TGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCC

CTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGC

TAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTC

ACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTT

GGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGG

CTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCC

ATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTT

TTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCC

TCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGAC

GGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATC

CGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGG

GTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTT

CCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGG

GAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTG

CGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATA

CGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGG

CCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAG

GCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCG

AAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGT

GCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTT

CGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTA

GGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGC

TGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTAT

CGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCG

GTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAG

TATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAG

CTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAG

CAGCAGATTACGCGCAGAAAAAAAGGATCTCAA (SEQ ID NO: 111)

[00484] Construct 159

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAGGGCATCTGC

AGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTG

CCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCC

AGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGCGATTCTCTGACAGATC

TGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCG

ACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGGAGGAGAACAGCT

CCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTG

AGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGT

GGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGAT

AGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGTG

GGAGCGGCGGGAGCGGTGGGAGCATGAAGTGCCTTTTGTACTTAGCCTTTTTATT

CATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGAAA

CTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAAATT

GGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGTCACA

AGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTG

TGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTCACT

CCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACTTGG

CTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCG

AAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACACAGG

AGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATGCCC

CACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGT

GATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTAT CATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAA

CTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCC

CATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATT

CCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGAT

GTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAA

CCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCT

TGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTA

AAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAA

GAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGATGACT

GGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTT

CAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGATCTT

CATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTT

CGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAA

TCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCT

TTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTAT

CCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACAT

AGAGATGAACCGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCATG

TTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGA

_{GTTTTTAATTTTTATGAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCG}

AGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGG

CCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTA

TGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTT

ATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATA

TGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCA

ACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCAT

CAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGA

CTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCT

AAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCC

CAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAAT

TCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCA

CACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTG

AGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACC

TGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGC GTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGG

CTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAA

TCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAG

GAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGAC

GAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTA

TAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGA

CCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTT

TCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGC

TGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAA

CTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCC

ACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTG

AAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTC

TGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAAC

AAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAG

AAAAAAAAGGATCTCAA (SEQ ID NO: 112)

[00485] Construct 160

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAG

ACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGA

AGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACA

AAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTG

GCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGA

GCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAG

CAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTG

CGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCC

AAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCC

TTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCC

TGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCC

TGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAA

GAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTG

TTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGC

CTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGA

TCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGC

GGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCT

CCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTG

CTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCC

TCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGC

AGCGGTGGGAGCGGCATGCTGCCTGTGGCTGTGCTGGTGGCCCTGCTCGCCGTGA

TCGTGCTGGTCGCCCTGCTGCTGCTGTGGCGGAGAAGACAGAAGAGACGGACCT

AACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATA

CCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAA

AAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCA

GGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATA

CCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTT

GAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTT

GGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAA

ACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCT

GCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCT

GCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTAT ATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTT

ACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTC

TCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGT

TTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAG

CATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGC

GTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAA

TGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTT

CCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGC

TCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAA

GAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGT

TGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACG

CTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCC

CCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATAC

CTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAG

GTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCC

CCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACC

CGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCA

GAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACG

GCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTT

CGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGG

TGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA

(SEQ ID NO: 113)

[00486] Construct 161

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAG

ACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGA

AGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACA

AAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTG

GCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGA

GCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAG

CAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTG

CGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCC

AAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCC

TTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCC

TGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCC

TGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAA

GAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTG

TTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGC

CTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGA

TCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGC

GGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCT

CCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTG

CTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCC

TCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGC

AGCGGTGGGAGCATCGTGATCATCTCTAGCAGCCTGCTGCTGGGCCTGATCGTGC

TGCTGCTGATCAGCTACGTGATGTGGAAGGCCGGCCTCTTCAAAAAACAGTACA

AGTCCTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTT

GTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAA

AAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTC

AGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTC

ACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAA GCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATA

GTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATC

ATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATAT

GCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACA

GCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTT

TTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACA

TGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCC

CTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCAT

AGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGC

CGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATT

AATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTG

CATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCT

TCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGG

TATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACG

CAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAG

GCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAA

ATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGG

CGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACC

GGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCAC

GCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCA

CGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAG

TCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGG

ATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCT

AACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAG

TTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTG

GTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATC

TCAA (SEQ ID NO: 114)

[00487] Construct 162

AAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCG

CCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTC

AGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTC

AGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAG

ACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAG

GTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACT

AGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAA

GAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTT

TGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTT

GATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATT

TTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAAT

GAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCA

ATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAG

TTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGG

CCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCA

GCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTA

TCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGC

CAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACG

CTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTT ACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCG

TTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCA

TAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACT

CAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGC

GTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATT

GGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCA

GTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACC

AGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAAT

AAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGA

AGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGA

AAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAAT

TGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCAT

TTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGA

CCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAA

CGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACT

ACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTA

AATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCG

AACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCT

GGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGC

GCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGG

GCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGC

TGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAA

ACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTC

CACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCAT

ATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACAT

TGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCC

CATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACC

GCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACG

CCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCC

ACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAA

TGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTT

CCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGT

TTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAG TCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGAC

TTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTG

TACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTG

GAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAG

CCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGT

TCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAG

GGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAA

TTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTT

CATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAAT

TCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAG

GCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTAT

AATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAAT

ATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATG

GTTACAATGATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCG

GGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAA

CGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCC

TCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGG

CCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAGACCTGGATCCTGACAT

GCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTG

CAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCT

GCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCC

CAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGA

TCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATC

GACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGC

TCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCT

GAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGG

TGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGA

TAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCC

CTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGAT

AGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCG

GCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGG

CCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGG

AGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGCGGT AGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCC

AGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAG

AGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGC

GGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCCCTC

TGTTCATCCCCGTGGCCGTGATGGTGACCGCCTTCAGCGGCCTGGCTTTTATCATC

TGGCTGGCCAGAAGACTGAAGAAGGGCAAGAAATCTAAGCGGTAACTCAAATCC

TGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAA

GAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAACGGA

ATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAG

AAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTT

TTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTC

TGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTC

TCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGT

ATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGG

TTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTA

TTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTT

_{ATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTT}

CCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCC

TCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATT

GTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAG

CCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCC

CGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGC

GCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACT

CGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGT

AATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAA

AAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCC

ATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGT

GGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGG (SEQ ID

NO: 115)

[00488] Construct 163

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAG

ACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGA

AGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACA

AAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTG

GCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGA

GCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAG

CAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTG

CGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCC

AAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCC

TTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCC

TGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCC

TGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAA

GAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTG

TTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGC

CTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGA

TCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGC

GGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCT

CCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTG

CTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCC TCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGC

AGCGGTGGGAGCCTGCTGGCTATCCTGATCCTGGCCCTGGTCGCCACAATCTTCT

TCGTGTGCACCGTGGTGCTGGCCGTGAGACTGAGCAGAAAGGGCCACATGTACC

CTGTGCGGAACTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAAT

CAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTT

ATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCA

CTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCT

GGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATC

ATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTG

CAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGC

AAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCC

CATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATG

AAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTT

AGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTC

CTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAG

CTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCAT

GTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATA

CGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTC

ACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCC

AGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGC

GCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGA

GCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGAT

AACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAA

AAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCAC

AAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATAC

CAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCT

TACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCT

CACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGT

GCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTT

GAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAAC

AGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGG

CCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGC

CAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCG CTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGG

ATCTCAA (SEQ ID NO: 116)

[00489] Construct 164

GCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATC

ATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGAT

CCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTC

ACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGG

AATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTAT

TGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTT

AGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTA

AATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCT

CATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATA

GACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAG

AACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCA

CTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCAC TAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGG

CGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGC

GCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAA

TGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAA

GGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGT

GCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTA

AAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGC

TCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCC

ATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGAC

ATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAG

CCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGA

CCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAA

CGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGC

CCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTC

AATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACT

TTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCG

GTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCA

AGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGG

ACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGC

GTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCG

CCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATC

CAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGAT

TGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTT

CAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGA

TAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTC

TTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTT

AAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTT

CAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTG

TTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGG

AAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTT

TATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAA

ACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGG

GCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGG ATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGCCCTGCTGCTCCC

CCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAGACCTGGATCCTG

ACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCA

TCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTA

ATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCT

GCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGAC

AGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATC

ATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAAC

AGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACC

CCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCG

TGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAA

GGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGC

TCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGA

GATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCA

TCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAG

GGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCA

GGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGCG

GTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAG

CCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACA

AGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCT

GCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCAT

CGTGGGCATCATCGCCGGACTGGTGCTGTTCGGCGCCGTCATCACCGGCGCTGTG

GTGGCCGCCGTGATGTGGCGGAGAAAGTCTAGCGACAGAAAGGGCTAACTCAAA

TCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTC

AAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAC

GGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTAT

CAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGAT

_{CTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGA}

CTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTG

TGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAAT

GAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACA

AAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTC

CTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGT GTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATT

TTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGAT

CCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAA

ATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTA

AAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACT

GCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAA

CGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTG

ACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGC

GGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGC

AAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTT

CCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAG

GTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTC

CCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTC

TCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTC

GGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCC

GACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACG

ACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATG

TAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAA

GAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGT

TGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTT

TGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATC

TTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGG

TCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAG

TTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGC

TTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGC

CTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCC

AGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCA

ATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCC

GCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAG

TTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTC

GTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACA

TGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTG

TCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAA TTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAA

CCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCG (SEQ

ID NO: 117)

[00490] Construct 165

TTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCC

GATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAG

AAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCG

CGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCG

CCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTAT

TACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGC

CAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAAT

ACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAG

AGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATGTACATTTATATTGGC

TCATGTCCAACATTACCGCCATGTTGACATTGATTATTGACTAGTTATTAATAGTA

ATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAA

CTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGT

CAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCA ATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCAT

ATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATT

ATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATT

AGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGA

TAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGA

GTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGC

CCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAG

AGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGAC

CTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAAC

TTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATT

CATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGT

CCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGT

TGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAAC

TTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGT

AAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTAC

TTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTT

CTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACA

CCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAG

ATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATG

CCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCAT

CATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCC

CTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGAC

CTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTT

TAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGT

GAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCT

GAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGAT

GGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATT

TCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGAC

GACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTC

AAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACC

GGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGT

GGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCC

ATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCT AATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATG

GCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTG

GAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACG

AGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAG

GTGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGA

CCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGG

CCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACAT

CTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTG

ATCACCCTGTACTGCAGCGGTGGGAGCAACGTGGTGTGCGCCCTGGGCCTGACC

GTGAGCCTGGTCGGCATCATCATTGGAACAATCTTCATCATCAAGGGCCTGAGAA

AGAGCAACGCCGCTGAGCGGAGAGGCCCTCTGTAACTCAAATCCTGCACAACAG

ATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAA

TTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAACGGAATTCCTCGAG

GGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTG

GCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTG

CCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATA

AAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCG

GAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTT

AGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATA

AAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGA

AAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCT

TTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCC

TGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATC

GGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTC

ACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCC

TAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGT

CGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAG

GCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCG

GTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTAT

CCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAA

AAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGC

CCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCG

ACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTC CTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGC

GTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTC

GCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTT

ATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTG

GCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACA

GAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTA

TCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATC

CGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATT

ACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTG

ACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAA

AAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTA

AAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCA

CCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGT

GTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGAT

ACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGC

CGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCT

ATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCA

ACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGC

TTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTG

TGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGG

CCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATG

CCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAG

AATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATAC

CGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGG

CGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTC

GTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCA

AAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATG

TTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATT

GTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGG

TTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAATATTTTG

TTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATAGGCCGA

AATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTTGAGTGT

TGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAACGTCAA AGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCACCCTA

ATCAAGTT (SEQ ID NO: 118)

[00491] Construct 166

AGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCAC

ATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAG

CTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGC

TCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGC

GGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAA

CGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAA

AGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAA

AAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCA

GGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTA

CCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCA

CGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGC ACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGA

GTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAG

GATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCC

TAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCA

GTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCT

GGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGA

TCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAA

ACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGAT

CCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACT

TGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTC

TATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACG

GGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTC

ACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAG

AAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAA

GCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTA

CAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCC

CAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGC

TCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCA

TGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTT

TCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGAC

CGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAA

CTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGAT

CTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCT

TCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAA

ATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCT

TCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATAC

ATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCC

GAAAAGTGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAAT

TTTTGTTAAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTT

ATAAATCAAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACA

AGAGTCCACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCT

ATCAGGGCGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTC

GAGGTGCCGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGC TTGACGGGGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAG

GAGCGGGCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCA

CACCCGCCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCT

GCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTG

GCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCC

CAGTCACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTA

TAGGGCGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCA

TTGCATACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAAC

ATTACCGCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACG

GGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAA

ATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGAC

GTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAG

TATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTA

CGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTA

CATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTA

TTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGA

CTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGG

CACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGC

AAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAG

TGAACCGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAG

ACACCGGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAG

TTTGGGGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGG

AGGGGGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCAC

CATGGACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATT

GTCTCCTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCA

TTTGTAACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCT

CTAATCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGT

TTTAGAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAA

TTCTGGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATC

ATCCTGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAA

ATACTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTT

TCCTACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAA

GAATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACC GCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCC

AGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGT

GAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGA

CAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGC

CTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGC

TGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCT

GAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGA

GTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGA

GCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGAC

GCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCA

CCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCC

TCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGC

CAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGC

CCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGA

CAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAAC

GAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGG

GAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACC

TGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCC

GCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGG

CCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTA

CTGCAGCGGTGGGAGCATCGTGATCATCACCGTGGTCGCCGCCGCTGTGATCATG

GGCACAGCCGGCCTGAGCACCTACCTGTACAACAGACAGAGAAAGATCAAGAA

ATACCGGCTGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATC

AACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTA

TGAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCC

TCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCT

CACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGA

AGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAAT

AGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAAT

CATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATA

TGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAAC

AGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGAT

_{TTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTA} CATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGT

CCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTC

ATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACG

(SEQ ID NO: 119)

[00492] Construct 167

CGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGC

AAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAAT

GTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTAT

TGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGG

GTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAATATTTT

GTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATAGGCCG

AAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTTGAGTG

TTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAACGTCAA

AGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCACCCTA

ATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTAAAGG

GAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGAAAGG

AAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGCGGTC ACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGGCGCG

TCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCT

CTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTT

GGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAGTGAGC

GCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGGCGGCC

GCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATGTACAT

TTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGACTAGTT

ATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCG

CGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGC

CCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCC

ATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCA

AGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCC

GCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACA

TCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAAT

GGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACG

TCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAA

CAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTA

TATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCATCCACG

CTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGACCGAT

CCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTCGCTAT

TGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTAGAATG

GGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTTCACTT

TCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTAACTTT

TTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTTTATTT

GTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGGTATAT

TATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGATAAGG

TAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGGTAGA

AACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGATATAC

ACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGCTAAC

CATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTGTTGT

GCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATTCTGA

CACTATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCAC

GCCGCTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAA CTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGA

CCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACA

TGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGAT

CAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTT

CAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAA

CATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAA

AAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGA

ATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACAT

CTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGT

GACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGC

AGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGG

GCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCG

CTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCC

AGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAA

TTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCT

GCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGC

GGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCG

CCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCT

CTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCTACCTGTACGTGTTGAGC

GGCATCGGCGGACTGCTGCTGCTGCTCCTGATCTTCATCGTGCTGTACAAGGTGG

GCTTTTTCAAAAGAAACCTGAAGTAACTCAAATCCTGCACAACAGATTCTTCATG

TTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGA

_{GTTTTTAATTTTTATGAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGA}

GGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCC

AATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATG

GGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTAT

TTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATG

GGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAAC

ATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCA

GTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACT

TGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTA

AAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCC

AGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATT CGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCAC

ACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGA

GCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCT

GTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCG

TATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGC

TGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAAT

CAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGG

AACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACG

AGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTAT

AAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGAC

CCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTT

CTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCT

GGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAAC

TATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCA

CTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGA

AGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCT

GCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACA

AACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGA

AAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGT

GGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCT

TCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATA

TGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCA

GCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAAC

TACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGA

CCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGC

CGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGT

TGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTG

CCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAG

CTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAA

GCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGT

TATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTA

AGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTA

TGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCAC ATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAAC

TCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACT (SEQ ID

NO: 120)

[00493] Construct 168

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAG

ACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGA

AGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACA

AAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTG

GCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGA

GCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAG

CAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTG

CGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCC

AAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCC

TTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCC

TGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCC

TGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAA GAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTG

TTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGC

CTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGA

TCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGC

GGCGGTAGCCCCGGCCAACCTCGGGAACCCCAGGTGTACACCCTGCCTCCTAGC

CAGGAGGAAATGACCAAGAACCAGGTGTCCCTCACATGTCTGGTGAAGGGATTC

TACCCCAGCGACATCGCCGTGGAATGGGAGAGCAACGGCCAGCCTGAGAACAAC

TACAAGACCACCCCTCCAGTGCTGGACAGCGATGGCAGCTTCTTTCTGTATAGCA

GACTGACCGTGGACAAGTCCAGATGGCAGGAGGGCAATGTGTTCAGCTGCAGCG

TGATGCACGAGGCTCTGCACAACCACTACACACAGAAATCTCTGAGCCTGTCTCT

GGGCAAGAGCGGTGGGAGCGGCATGCTGCCTGTGGCTGTGCTGGTGGCCCTGCT

CGCCGTGATCGTGCTGGTCGCCCTGCTGCTGCTGTGGCGGAGAAGACAGAAGAG

ACGGACCTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAAC

TTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGA

AAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTC

AGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTC

ACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAA

GCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATA

GTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATC

ATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATAT

GCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACA

GCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTT

TTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACA

TGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCC

CTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCAT

AGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGC

CGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATT

AATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTG

CATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCT

TCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGG

TATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACG

CAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAG

GCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAA ATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGG

CGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACC

GGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCAC

GCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCA

CGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAG

TCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGG

ATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCT

AACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAG

TTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTG

GTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATC

TCAA (SEQ ID NO: 121)

[00494] Construct 169

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAG

ACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGA

AGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACA

AAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTG GCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGA

GCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAG

CAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTG

CGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCC

AAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCC

TTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCC

TGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCC

TGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAA

GAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTG

TTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGC

CTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGA

TCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGC

GGCGGTAGCCCCGGCCAACCTCGGGAACCCCAGGTGTACACCCTGCCTCCTAGC

CAGGAGGAAATGACCAAGAACCAGGTGTCCCTCACATGTCTGGTGAAGGGATTC

TACCCCAGCGACATCGCCGTGGAATGGGAGAGCAACGGCCAGCCTGAGAACAAC

TACAAGACCACCCCTCCAGTGCTGGACAGCGATGGCAGCTTCTTTCTGTATAGCA

GACTGACCGTGGACAAGTCCAGATGGCAGGAGGGCAATGTGTTCAGCTGCAGCG

TGATGCACGAGGCTCTGCACAACCACTACACACAGAAATCTCTGAGCCTGTCTCT

GGGCAAGAGCGGTGGGAGCATCGTGATCATCTCTAGCAGCCTGCTGCTGGGCCT

GATCGTGCTGCTGCTGATCAGCTACGTGATGTGGAAGGCCGGCTTCTTCAAAAGA

CAGTACAAGTCCTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAA

TCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTT

TATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCA

CTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCT

GGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATC

ATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTG

CAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGC

AAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCC

CATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATG

AAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTT

AGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTC

CTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAG

CTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCAT GTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATA

CGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTC

ACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCC

AGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGC

GCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGA

GCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGAT

AACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAA

AAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCAC

AAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATAC

CAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCT

TACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCT

CACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGT

GCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTT

GAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAAC

AGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGG

CCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGC

CAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCG

CTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGG

ATCTCAA (SEQ ID NO: 122)

[00495] Construct 170

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAG

ACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGA

AGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACA

AAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTG

GCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGA

GCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAG

CAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTG

CGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCC

AAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCC

TTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCC

TGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCC

TGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAA

GAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTG

TTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGC

CTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGA

TCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGC

GGCGGTAGCCCCGGCCAACCTCGGGAACCCCAGGTGTACACCCTGCCTCCTAGC

CAGGAGGAAATGACCAAGAACCAGGTGTCCCTCACATGTCTGGTGAAGGGATTC

TACCCCAGCGACATCGCCGTGGAATGGGAGAGCAACGGCCAGCCTGAGAACAAC

TACAAGACCACCCCTCCAGTGCTGGACAGCGATGGCAGCTTCTTTCTGTATAGCA

GACTGACCGTGGACAAGTCCAGATGGCAGGAGGGCAATGTGTTCAGCTGCAGCG

TGATGCACGAGGCTCTGCACAACCACTACACACAGAAATCTCTGAGCCTGTCTCT

GGGCAAGAGCGGTGGGAGCCCTCTGTTCATCCCCGTGGCCGTGATGGTGACCGC

CTTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGAAGACTGAAGAAGGGCAA

GAAATCTAAGCGGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAA

ATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTT

TTATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTC

ACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCC

TGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACAT CATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATT

GCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGG

CAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGC

CCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATAT

GAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGT

TAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTT

CCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATA

GCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATC

ATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACAT

ACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACT

CACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGC

CAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGG

CGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCG

AGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGA

TAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTA

AAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCA

CAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATA

CCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGC

TTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGC

TCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTG

TGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCT

TGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAA

CAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTG

GCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAG

CCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACC

GCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAG

GATCTCAA (SEQ ID NO: 123)

[00496] Construct 171

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAG

ACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGA

AGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACA

AAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTG

GCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGA

GCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAG

CAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTG

CGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCC

AAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCC

TTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCC

TGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCC

TGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAA

GAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTG

TTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGC

CTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGA

TCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGC

GGCGGTAGCCCCGGCCAACCTCGGGAACCCCAGGTGTACACCCTGCCTCCTAGC

CAGGAGGAAATGACCAAGAACCAGGTGTCCCTCACATGTCTGGTGAAGGGATTC

TACCCCAGCGACATCGCCGTGGAATGGGAGAGCAACGGCCAGCCTGAGAACAAC

TACAAGACCACCCCTCCAGTGCTGGACAGCGATGGCAGCTTCTTTCTGTATAGCA

GACTGACCGTGGACAAGTCCAGATGGCAGGAGGGCAATGTGTTCAGCTGCAGCG TGATGCACGAGGCTCTGCACAACCACTACACACAGAAATCTCTGAGCCTGTCTCT

GGGCAAGAGCGGTGGGAGCCTGCTGGCTATCCTGATCCTGGCCCTGGTCGCCAC

AATCTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAGACTGAGCAGAAAGGGCCA

CATGTACCCTGTGCGGAACTAACTCAAATCCTGCACAACAGATTCTTCATGTTTG

GACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTT

TTAATTTTTATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGA

GGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCC

AATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATG

GGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTAT

TTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATG

GGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAAC

ATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCA

GTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACT

TGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTA

AAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCC

AGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATT

CGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCAC

ACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGA

GCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCT

GTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCG

TATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGC

TGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAAT

CAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGG

AACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACG

AGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTAT

AAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGAC

CCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTT

CTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCT

GGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAAC

TATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCA

CTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGA

AGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCT

GCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACA AACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGA

AAAAAAGGATCTCAA (SEQ ID NO: 124)

[00497] Construct 172

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAG

ACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGA

AGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACA

AAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTG

GCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGA

GCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAG

CAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTG

CGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCC

AAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCC

TTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCC

TGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCC

TGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAA

GAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTG TTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGC

CTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGA

TCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGC

GGCGGTAGCCCCGGCCAACCTCGGGAACCCCAGGTGTACACCCTGCCTCCTAGC

CAGGAGGAAATGACCAAGAACCAGGTGTCCCTCACATGTCTGGTGAAGGGATTC

TACCCCAGCGACATCGCCGTGGAATGGGAGAGCAACGGCCAGCCTGAGAACAAC

TACAAGACCACCCCTCCAGTGCTGGACAGCGATGGCAGCTTCTTTCTGTATAGCA

GACTGACCGTGGACAAGTCCAGATGGCAGGAGGGCAATGTGTTCAGCTGCAGCG

TGATGCACGAGGCTCTGCACAACCACTACACACAGAAATCTCTGAGCCTGTCTCT

GGGCAAGAGCGGTGGGAGCATCGTGGGCATCATCGCCGGACTGGTGCTGTTCGG

CGCCGTCATCACCGGCGCTGTGGTGGCCGCCGTGATGTGGCGGAGAAAGTCTAG

CGACAGAAAGGGCTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCA

AATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATT

TTTATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATT

CACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCC

CTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACA

TCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATT

GCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGG

CAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGC

CCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATAT

GAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGT

TAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTT

CCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATA

GCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATC

ATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACAT

ACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACT

CACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGC

CAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGG

CGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCG

AGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGA

TAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTA

AAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCA

CAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATA CCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGC

TTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGC

TCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTG

TGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCT

TGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAA

CAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTG

GCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAG

CCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACC

GCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAG

GATCTCAA (SEQ ID NO: 125)

[00498] Construct 173

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAG

ACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGA

AGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACA

AAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTG

GCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGA GCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAG

CAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTG

CGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCC

AAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCC

TTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCC

TGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCC

TGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAA

GAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTG

TTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGC

CTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGA

TCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGC

GGCGGTAGCCCCGGCCAACCTCGGGAACCCCAGGTGTACACCCTGCCTCCTAGC

CAGGAGGAAATGACCAAGAACCAGGTGTCCCTCACATGTCTGGTGAAGGGATTC

TACCCCAGCGACATCGCCGTGGAATGGGAGAGCAACGGCCAGCCTGAGAACAAC

TACAAGACCACCCCTCCAGTGCTGGACAGCGATGGCAGCTTCTTTCTGTATAGCA

GACTGACCGTGGACAAGTCCAGATGGCAGGAGGGCAATGTGTTCAGCTGCAGCG

TGATGCACGAGGCTCTGCACAACCACTACACACAGAAATCTCTGAGCCTGTCTCT

GGGCAAGAGCGGTGGGAGCAACGTGGTGTGCGCCCTGGGCCTGACCGTGGGCCT

GGTCGGCATCATCATTGGAACAATCTTCATCATCAAGGGCCTGAGAAAGAGCAA

CGCCGCTGAGCGGAGAGGCCCTCTGTAACTCAAATCCTGCACAACAGATTCTTCA

TGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTT

GAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATC

CGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGT

GTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAA

ATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAA

ATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGA

CATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTT

GGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGG

TCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCC

TTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACAT

CCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTA

CTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCG

CAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAAT TCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATG

AGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGA

AACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGT

TTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGT

TCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCAC

AGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGG

CCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCC

TGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGG

ACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTT

CCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGG

CGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCC

AAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCG

GTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGC

AGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTT

CTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGC

GCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCA

AACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCG

CAGAAAAAAAGGATCTCAA (SEQ ID NO: 126)

[00499] Construct 174

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAG

ACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGA

AGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACA

AAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTG

GCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGA

GCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAG

CAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTG

CGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCC

AAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCC

TTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCC

TGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCC

TGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAA

GAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTG

TTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGC

CTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGA

TCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGC GGCGGTAGCCCCGGCCAACCTCGGGAACCCCAGGTGTACACCCTGCCTCCTAGC

CAGGAGGAAATGACCAAGAACCAGGTGTCCCTCACATGTCTGGTGAAGGGATTC

TACCCCAGCGACATCGCCGTGGAATGGGAGAGCAACGGCCAGCCTGAGAACAAC

TACAAGACCACCCCTCCAGTGCTGGACAGCGATGGCAGCTTCTTTCTGTATAGCA

GACTGACCGTGGACAAGTCCAGATGGCAGGAGGGCAATGTGTTCAGCTGCAGCG

TGATGCACGAGGCTCTGCACAACCACTACACACAGAAATCTCTGAGCCTGTCTCT

GGGCAAGAGCGGTGGGAGCATCGTGATCATCACCGTGGTCGCCGCCGCTGTGAT

CATGGGCACAGCCGGCCTGAGCACCTACCTGTACAACAGACAGAGAAAGATCAA

GAAATACCGGCTGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAA

ATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTT

TTATGAAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATT

CACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCC

CTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACA

TCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATT

GCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGG

CAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGC

CCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATAT

GAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGT

TAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTT

CCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATA

GCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATC

ATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACAT

ACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACT

CACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGC

CAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGG

CGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCG

AGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGA

TAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTA

AAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCA

CAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATA

CCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGC

TTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGC

TCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTG TGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCT

TGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAA

CAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTG

GCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAG

CCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACC

GCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAG

GATCTCAA (SEQ ID NO: 127)

[00500] Construct 175

TCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCT

GGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCA

TAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTA

AACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATT

GACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTAT

GGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGT

GATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGG ATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAAT

CAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGC

GGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGT

CAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGG

GACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGGGG

ACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGGGG

CAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATGGA

CCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTCCT

CTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGTAA

CGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAATCA

_{CTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTAGAG}

AACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCTGGC

TGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCCTGC

CTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATACTCT

GAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACA

GCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTC

CTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGCCCTG

CTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAGACCT

GGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGAC

CGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCT

GGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATG

GACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGAT

TCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATT

ACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGA

AAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGAC

TGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAA

GGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCC

CCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGG

CCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACC

CCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAG

CCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGC

CTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGC

ATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGG TAGCCCCGGCCAACCTCGGGAACCCCAGGTGTACACCCTGCCTCCTAGCCAGGA

GGAAATGACCAAGAACCAGGTGTCCCTCACATGTCTGGTGAAGGGATTCTACCC

CAGCGACATCGCCGTGGAATGGGAGAGCAACGGCCAGCCTGAGAACAACTACA

AGACCACCCCTCCAGTGCTGGACAGCGATGGCAGCTTCTTTCTGTATAGCAGACT

GACCGTGGACAAGTCCAGATGGCAGGAGGGCAATGTGTTCAGCTGCAGCGTGAT

GCACGAGGCTCTGCACAACCACTACACACAGAAATCTCTGAGCCTGTCTCTGGGC

AAGAGCGGTGGGAGCTACCTGTACGTGCTGAGCGGCATCGGCGGACTGCTGCTG

CTGCTCCTGATCTTCATCGTGCTGTACAAGGTGGGCTTTTTCAAAAGAAACCTGA

AGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTG

ATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAA

AAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGT

GCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAA

ATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCC

CTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGT

GTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTT

AAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTG

GCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCC

CCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTT

TATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGT

TTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTC

TTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGC

TGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGG

AAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAAT

TGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCAT

TAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCC

GCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTAT

CAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAG

GAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCC

GCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATC

GACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGT

TTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGA

TACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTG

TAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAA CCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCA

ACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTA

GCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACT

ACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTAC

CTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAG

CGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGT (SEQ ID NO: 128)

[00501] Construct 176

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGAAGTGCCTTTTGTACTT

AGCCTTTTTATTCATTGGGGTGAATTGCAAAAAAACCCAGACCTGGATCCTGACA

TGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCT

GCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATC

TGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCC

CAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGA

TCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATC GACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGC

TCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCT

GAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGG

TGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGA

TAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCC

CTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGAT

AGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCG

GCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGG

CCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGG

AGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGG

AGCGGCATGCTGCCTGTGGCTGTGCTGGTGGCCCTGCTCGCCGTGATCGTGCTGG

TCGCCCTGCTGCTGCTGTGGCGGAGAAGACAGAAGAGACGGACCTAACTCAAAT

CCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCA

AAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAA

CGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTA

TCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGA

TCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTG

ACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTT

GTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAA

TGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAAC

AAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATT

CCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTT

GTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGA

TTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAG

ATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTG

AAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTG

TAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCA

CTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCC

AACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCAC

TGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAG

GCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGA

GCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTT

TTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAG AGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGC

TCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTT

TCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTT

CGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCC

CGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACAC

GACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTAT

GTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGA

AGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAG

TTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGT

TTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA (SEQ ID NO: 129)

[00502] Construct 180

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGAAGTGCCTTTTGTACTT

AGCCTTTTTATTCATTGGGGTGAATTGCAAAAAAACCCAGACCTGGATCCTGACA

TGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCT

GCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATC

TGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCC

CAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGA

TCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATC GACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGC

TCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCT

GAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGG

TGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGA

TAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCC

CTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGAT

AGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCG

GCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGG

CCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGG

AGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGG

AGCCCTCTGTTCATCCCCGTGGCCGTGATGGTGACCGCCTTCAGCGGCCTGGCTT

TTATCATCTGGCTGGCCAGAAGACTGAAGAAGGGCAAGAAATCTAAGCGGTAAC

TCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCA

TGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAA

AAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGG

CTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCA

CTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAG

CATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGA

_{ATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACA}

TCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCC

ATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCT

GTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATT

TTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACT

AGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCT

TATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTC

CTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCAT

AAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTG

CGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAA

TCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTC

GCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCAC

TCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAAC

ATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCT

GGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCA AGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCT

GGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGT

CCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTAT

CTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCG

TTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGT

AAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGC

GAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTA

CACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGA

AAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGT

_{TTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA (SEG ID}

NO: 130)

[00503] Construct 182

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGAAGTGCCTTTTGTACTT

AGCCTTTTTATTCATTGGGGTGAATTGCAAAAAAACCCAGACCTGGATCCTGACA

TGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCT

GCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATC

TGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCC CAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGA

TCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATC

GACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGC

TCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCT

GAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGG

TGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGA

TAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCC

CTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGAT

AGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCG

GCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGG

CCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGG

AGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGG

AGCCTGCTGGCTATCCTGATCCTGGCCCTGGTCGCCACAATCTTCTTCGTGTGCAC

CGTGGTGCTGGCCGTGAGACTGAGCAGAAAGGGCCACATGTACCCTGTGCGGAA

CTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGA

TACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAA

AAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGT

GCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAA

ATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCC

CTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGT

GTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTT

AAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTG

GCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCC

CCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTT

TATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGT

TTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTC

TTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGC

TGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGG

AAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAAT

TGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCAT

TAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCC

GCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTAT

CAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAG GAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCC

GCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATC

GACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGT

TTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGA

TACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTG

TAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAA

CCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCA

ACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTA

GCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTAGCCTAACT

ACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTAC

CTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAG

CGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA

(SEQ ID NO: 131)

[00504] Construct 183

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGAAGTGCCTTTTGTACTT

AGCCTTTTTATTCATTGGGGTGAATTGCAAAAAAACCCAGACCTGGATCCTGACA

TGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCT GCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATC

TGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCC

CAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGA

TCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATC

GACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGC

TCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCT

GAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGG

TGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGA

TAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCC

CTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGAT

AGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCG

GCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGG

CCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGG

AGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCCTGCTGGCTATCCTGA

TCCTGGCCCTGGTCGCCACAATCTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAG

ACTGAGCAGAAAGGGCCACATGTACCCTGTGCGGAACTAACTCAAATCCTGCAC

AACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGC

CTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAACGGAATTC

CTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAG

GTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTC

CCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGG

CTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCT

CACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATT

TGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTG

GCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTC

CATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTT

TTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTC

CTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGA

CGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTAT

CCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGG

GGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTT

TCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGG

GGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCT GCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAAT

ACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAG

GCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATA

GGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGC

GAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCG

TGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCT

TCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGT

AGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCG

CTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTA

TCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGC

GGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACA

GTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTA

GCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAA

GCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA (SEQ ID NO: 132)

[00505] Construct 193

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGAAGTGCCTTTTGTACTT

AGCCTTTTTATTCATTGGGGTGAATTGCACCAAAAGAGTGCGGCTGTCTGATAGC

TTCAATCCTGTGTACCCCTACGAGGACGAGAGCACCTCCCAGCACCCCTTCTACA ACCCCGGCTTCATCAGCCCTAATGGCTTTACCCAAAGCCCAGATGGCGTGCTGAC

CCTGAAGTGCCTGACCCCTCTCACCACCACAGGCGGCTCCCTGCAACTGAAGGTG

GGCGGAGGACTGACCGTGGACGACACCGACGGCACACTGCAGGAGAACATCAG

AGCCACCGCCCCTATCACCAAGAACAACCACAGCGTGGAACTGAGCATCGGCAA

CGGCCTGGAAACCCAGAACAACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAA

GTTCAACAACGGAGATATCTGTATCAAGGACTCTATCAACACCCTGTGGACCGG

AATCAACCCTCCACCTAATTGCCAGATCGTGGAAAACACCAATACCAACGACGG

CAAGCTGACACTCGTGCTGGTTAAGAACGGAGGCCTGGTCAACGGCTACGTGTC

CCTGGTCGGCGTGTCCGATACAGTGAACCAGATGTTCACACAGAAGACCGCTAA

TATTCAGCTGAGACTGTATTTCGACTCCAGTGGCAACCTGCTGACAGAGGAATCT

GACCTGAAAATCCCCCTGAAAAACAAGAGCAGCACCGCCACATCTGAGACAGTG

GCCAGCAGCAAGGCCTTCATGCCTAGCACCACAGCTTATCCTTTTAACACCACCA

CACGGGACAGCGAGAACTACATCCACGGCATCTGCTACTACATGACCAGCTACG

ACAGAAGCCTGTTCCCCCTGAACATTAGCATCATGCTGAACAGCAGGATGATCA

GCAGCAACGTGGCTTACGCCATCCAGTTCGAGTGGAACCTGAACGCCAGCGAGA

GCCCTGAGTCTAATATCGCCACACTGACCACATCTCCTTTTTTCTTCAGCTACATC

ACCGAAGATGACAACAGCGGTGGGAGCGGTGGGAGCATTGCCTCTTTTTTCTTTA

TCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGC

ATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAAC

CGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAA

TCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTT

TATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCA

CTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCT

GGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATC

ATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTG

CAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGC

AAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCC

CATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATG

AAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTT

AGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTC

CTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAG

CTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCAT

GTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATA CGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTC

ACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCC

AGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGC

GCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGA

GCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGAT

AACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAA

AAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCAC

AAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATAC

CAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCT

TACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCT

CACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGT

GCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTT

GAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAAC

AGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGG

CCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGC

CAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCG

CTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGG

ATCTCAA (SEQ ID NO: 133)

[00506] Construct 195

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGAAGTGCCTTTTGTACTT

AGCCTTTTTATTCATTGGGGTGAATTGCAAAAAAACCCAGACCTGGATCCTGACA

TGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCT

GCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATC

TGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCC

CAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGA

TCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATC

GACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGC

TCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCT

GAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGG

TGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGA

TAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCC

CTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGAT

AGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCG

GCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGG

CCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGG

AGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGG

AGCATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTT

CACCATAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAAT

TACCATTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCA

CAGCCTTACAAGTCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTT

GGATGTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACC

GAAGTATATAACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAG

GAAAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCT

CAAAGTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTG

ACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGT

TCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAAC

CTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATG

GACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGC

ACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAA

ATGCAATACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAG

ATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGT CAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGT

TGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGC

GGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGA

ACCGGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGAT

ACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAG

TGGAACTACCACAGAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGT

GGAAATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTA

TACATGATTGGACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTC

AGGTGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGA

GAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAA

GGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTT

AATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAA

AGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAA

AGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTG

ATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAA

AAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGT

GCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAA

ATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCC

CTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGT

GTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTT

AAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTG

GCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCC

CCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTT

TATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGT

TTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTC

TTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGC

TGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGG

AAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAAT

TGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCAT

TAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCC

GCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTAT

CAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAG

GAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCC GCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATC

GACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGT

TTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGA

TACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTG

TAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAA

CCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCA

ACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTA

GCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACT

ACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTAC

CTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAG

CGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA

(SEQ ID NO: 134)

[00507] Construct 211

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAG

ACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGA

AGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACA

AAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTG

GCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGA

GCGATTCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAG

CAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTG

CGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCC AAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCC

TTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCC

TGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCC

TGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAA

GAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTG

TTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGC

CTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGA

TCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGC

GGCGGGAGCGGTGGGAGCATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTG

GGGTGAATTGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGAAACTGGA

AAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAAATTGGCAT

AATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCAAGAGTCACAAGGCT

ATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTGTGATT

TCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTCACTCCATC

TGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACTTGGCTGA

ATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCGAAGC

AGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAA

TGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTG

TCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTC

TAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCC

CTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGA

GGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCCCATCA

GGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTG

AATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAG

TCTAATTCAGGACGTTGAGAGGATCCTGGATTATTCCCTCTGCCAAGAAACCTGG

AGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTC

CTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATA

CTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATG

GTCGGAATGATCAGTGGAACTACCACAGAAAGGGAACTGTGGGATGACTGGGCA

CCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGA

TATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGATCTTCATCT

TAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAA

CTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAAT CGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCT

TTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTT

TGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATG

AACCGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACC

AAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAA

TTTTTATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAA

TTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATG

CCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGA

CATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTC

ATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGA

GGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATA

TGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTAT

ATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAG

GTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATT

TTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCAT

AGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAAT

CATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAAC

ATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAA

CTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGT

GCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTG

GGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGG

CGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGG

GATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCG

TAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCAT

CACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAG

ATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGC

CGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCAT

AGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCT

GTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCG

TCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGT

AACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGG

TGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGA

AGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCA CCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAA

AGGATCTCAA (SEQ ID NO: 135)

[00508] Construct 212

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAG

ACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGA

AGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACA

AAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTG

GCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGA

GCGATTCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAG

CAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTG

CGTGGAGGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCC

AAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCC

TTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCC

TGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCC

TGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAA

GAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTG

TTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGC

CTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGA TCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGC

GGCGGGAGCGGTGGGAGCATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTG

GGGTGAATTGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGAAACTGGA

AAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAAATTGGCAT

AATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCAAGAGTCACAAGGCT

ATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTGTGATT

TCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTCACTCCATC

TGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACTTGGCTGA

ATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCGAAGC

AGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAA

TGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTG

TCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTC

TAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCC

CTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGA

GGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCCCATCA

GGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTG

AATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAG

TCTAATTCAGGACGTTGAGAGGATTCTGGATTATTCCCTCTGCCAAGAAACCTGG

AGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTC

CTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATA

CTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATG

GTCGGAATGATCAGTGGAACTACCACAGAAAGGGAACTGTGGGATGACTGGGCA

CCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGA

TATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGATCTTCATCT

TAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAA

CTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAAT

CGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCT

TTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTT

TGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATG

AACCGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACC

AAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAA

TTTTTATGAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAAT

TCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGC CCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGAC

ATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCA

TTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAG

GGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATAT

GCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTAT

ATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAG

GTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATT

TTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCAT

AGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAAT

CATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAAC

ATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAA

CTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGT

GCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTG

GGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGG

CGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGG

GATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCG

TAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCAT

CACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAG

ATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGC

CGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCAT

AGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCT

GTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCG

TCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGT

AACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGG

TGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGA

AGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCA

CCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAA

AGGATCTCAA (SEQ ID NO: 136)

[00509] Construct 213

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGAGGGCATCTGCAGAA

ATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCA

AGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCC

ACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCT

GGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAA

GCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAA

GGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGA

ATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCC

TCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCA

GAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGTGGGAG

CGGCGGGAGCGGTGGGAGCATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATT

GGGGTGAATTGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGAAACTGG

AAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAAATTGGC

ATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCAAGAGTCACAAGG

CTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTGTGA

TTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTCACTCCA

TCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACTTGGCTG

AATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCGAAG

CAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGA

ATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACT

GTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATT

CTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATC

CCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTGG

AGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCCCATC AGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCT

GAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAA

GTCTAATTCAGGACGTTGAGAGGATCCTGGATTATTCCCTCTGCCAAGAAACCTG

GAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCT

CCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTAAAAT

ACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAAT

GGTCGGAATGATCAGTGGAACTACCACAGAAAGGGAACTGTGGGATGACTGGGC

ACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGG

ATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGATCTTCATC

TTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCA

ACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCA

ATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTT

CTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATC

TTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGA

TGAACCGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGA

CCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTT

AATTTTTATGAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGA

ATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAAT

GCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGG

ACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTT

CATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGG

AGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACAT

ATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGT

ATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTG

AGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAA

ATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGT

CATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGT

AATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACA

ACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCT

AACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTC

GTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTAT

TGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGC

GGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAG GGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAAC

CGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGC

ATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAA

GATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCT

GCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTC

ATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGG

CTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTAT

CGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTG

GTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGT

GGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCT

GAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAAC

CACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAA

AAAGGATCTCAA (SEQ ID NO: 137)

[00510] Construct 214

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGAAGTGCCTTTTGTACTT

AGCCTTTTTATTCATTGGGGTGAATTGCGAACTTACAGAACTGCTGCTGGTCGTG ATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCG

ACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACGTGCTGCACTCCAGAC

TGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTG

GACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGAGACAAAGGCCCAGGA

CATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCA

GCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTGAGTGGACAGGTGCG

CCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAACTCCCACCTCAGGGC

AGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTGAGCTTCCAGCACCTGC

TGCGGGGCAAGGTGCGGTTTCTGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCG

GAGAGCCCCTCCTACCACCGCCGTGCCCAGCCGGACATCTCTGGTTCTCACCCTG

AACGAGCTGCCTAATAGAACGAGCGGCCTGCTGGAAACCAACTTCACCGCCAGC

GCCAGAACCACAGGCTCTGGTCTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAA

ATCCCCGGCCTGCTGAACCAGACATCTAGAAGCCTTGATCAGATCCCTGGCTACC

TGAACAGAATCCACGAGCTGCTGAACGGCACCAGAGGCCTCTTCCCCGGACCCT

CTAGAAGAACCCTGGGAGCTCCTGATATCAGCAGCGGCACAAGCGACACCGGCA

GCCTGCCACCTAACCTGCAACCTGGATATAGCCCCAGCCCCACTCACCCCCCCAC

AGGCCAGTACACCCTGTTTCCTCTGCCTCCTACACTGCCAACACCCGTGGTCCAG

CTGCACCCCCTGCTGCCTGACCCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCT

GCTGAATACCAGCTACACACACAGCCAGAACCTGTCTCAGGAGGGCAGCGGTGG

GAGCGGTGGGAGCATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTAT

TCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAA

AAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAAATC

CTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAA

AGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAACG

GAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATC

AGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATC

TTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGAC

TTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGT

GTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATG

AGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAA

AGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCC

TTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGT

GTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATT TTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGAT

CCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAA

ATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTA

AAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACT

GCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAA

CGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTG

ACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGC

GGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGC

AAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTT

CCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAG

GTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTC

CCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTC

TCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTC

GGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCC

GACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACG

ACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATG

TAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAA

GAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGT

TGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTT

TGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA (SEQ ID NO: 138)

[00511] Construct 215

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGC

GAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCT

GGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATG

GACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGAT

TCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATT

ACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGA

AAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGAC

TGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAA

GGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCC

CCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGG

CCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATTGCCTCTTTTTTCTTTAT CATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCA

TTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACC

GACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAAT

CAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTT

ATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCA

CTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCT

GGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATC

ATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTG

CAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGC

AAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCC

CATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATG

AAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTT

AGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTC

CTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAG

CTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCAT

GTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATA

CGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTC

ACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCC

AGCTGCATTAATGAATCGGCCAACGCGCGGGGA (SEQ ID NO: 139)

[00512] Construct 216

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGC

GAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCT

GGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATG

GACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGCGAT

TCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCAATT

ACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGA

AAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGAC

TGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAA

GGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCC

CCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGG

CCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATTGCCTCTTTTTTCTTTAT

CATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCA

TTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACC

GACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAAT CAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTT

ATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCA

CTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCT

GGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATC

ATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTG

CAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGC

AAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCC

CATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATG

AAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTT

AGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTC

CTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAG

CTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCAT

GTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATA

CGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTC

ACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCC

AGCTGCATTAATGAATCGGCCAACGCGCGGGGA (SEQ ID NO: 140)

[00513] Construct 217

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGC

GAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCT GGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATG

GACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGCGAT

TCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCAATT

ACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGG

AGGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGAC

TGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAA

GGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCC

CCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGG

CCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATTGCCTCTTTTTTCTTTAT

CATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCA

TTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACC

GACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAAT

CAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTT

ATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCA

CTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCT

GGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATC

ATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTG

CAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGC

AAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCC

CATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATG

AAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTT

AGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTC

CTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAG

CTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCAT

GTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATA

CGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTC

ACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCC

AGCTGCATTAATGAATCGGCCAACGCGCGGGGA (SEQ ID NO: 141)

[00514] Construct 218

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGC

GAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCT

GGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATG

GACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGCGAT

TCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCAATT

ACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGG AGGAGAACAGCTCCAAGGACCGGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGA

CTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTA

AGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTC

CCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTG

GCCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATTGCCTCTTTTTTCTTTA

TCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGC

ATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAAC

CGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAA

TCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTT

TATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCA

CTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCT

GGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATC

ATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTG

CAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGC

AAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCC

CATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATG

AAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTT

AGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTC

CTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAG

CTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCAT

GTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATA

CGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTC

ACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCC

AGCTGCATTAATGAATCGGCCAACGCGCGGGGA (SEQ ID NO: 142)

[00515] Construct 219

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAG

ACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGA

AGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACA

AAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTG

GCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGA

GCGATTCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAG

CAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTG

CGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCC

AAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCC

TTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCC

TGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCC

TGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAA

GAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTG

TTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGC

CTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGA

TCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGC

GGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGA

AACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAA

ATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCAAGAGTC ACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTAC

TTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTC

ACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACT

TGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATG

CCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACAC

AGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATG

CCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTA

TGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGC

TATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATG

AAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGAC

TCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAG

ATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTG

GATGTAAGTCTAATTCAGGACGTTGAGAGGATCCTGGATTATTCCCTCTGCCAAG

AAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTA

TCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCT

CAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAAGGGAACTGTGGGATG

ACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCA

GTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGA

TCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCT

GCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAA

AAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCC

TCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGT

ATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCA

TGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTT

GAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATC

CGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGT

GTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAA

ATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAA

ATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGA

CATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTT

GGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGG TCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCC

TTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACAT

CCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTA

CTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCG

CAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAAT

TCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATG

AGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGA

AACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGT

TTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGT

TCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCAC

AGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGG

CCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCC

TGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGG

ACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTT

CCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGG

CGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCC

AAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCG

GTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGC

AGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTT

CTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGC

GCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCA

AACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCG

CAGAAAAAAAGGATCTCAA (SEQ ID NO: 143)

[00516] Construct 220

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAAAAAAACCCAG

ACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGA

AGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACA

AAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTG

GCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGA

GCGATTCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAG

CAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTG

CGTGGAGGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCC

AAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCC

TTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCC

TGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCC

TGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAA

GAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTG

TTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGC

CTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGA

TCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGC

GGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGA

AACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAA

ATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCAAGAGTC

ACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTAC

TTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTC

ACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACT

TGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATG

CCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACAC

AGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATG

CCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTA

TGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGC TATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATG

AAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGAC

TCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAG

ATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTG

GATGTAAGTCTAATTCAGGACGTTGAGAGGATCCTGGATTATTCCCTCTGCCAAG

AAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTA

TCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCT

CAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAAGGGAACTGTGGGATG

ACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCA

GTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGA

TCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCT

GCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAA

AAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCC

TCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGT

ATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCA

TGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTT

GAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATC

CGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGT

GTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAA

ATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAA

ATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGA

CATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTT

GGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGG

TCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCC

TTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACAT

CCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTA

CTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCG

CAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAAT

TCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATG

AGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGA

AACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGT TTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGT

TCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCAC

AGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGG

CCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCC

TGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGG

ACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTT

CCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGG

CGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCC

AAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCG

GTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGC

AGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTT

CTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGC

GCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCA

AACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCG

CAGAAAAAAAGGATCTCAA (SEQ ID NO: 144)

[00517] Construct 221

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCT

GCACGCCGCTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCT

CCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGG

GTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGAC

TACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTT

GGATCAGCGAGATGCTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACA

AGCTGAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGG

TCAACATCGTGGACGACCTGGTTGAGTGCGTGGAGGAGAACAGCTCCAAGGACC

GGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTT

CAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAG

ACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTG

TCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACG

ACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGC

ACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTC

GGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAAC

ATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACG

GGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCAAGTTCA

CCATAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTA CCATTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACA

GCCTTACAAGTCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGG

ATGTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGA

AGTATATAACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGA

AAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCA

AAGTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGAC

TCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTC

ATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCT

GGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGA

CATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCAC

AGGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAAT

GCAATACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGAT

GGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCA

AGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTG

AGAGGATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGG

GTCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAAC

CGGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATAC

ATCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTG

GAACTACCACAGAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGG

AAATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATA

CATGATTGGACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAG

GTGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGA

GTTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGG

TTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAA

TCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAG

CACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG

TAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGAT

ACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAA

AAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTG

CAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAA

TACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCC

TTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGT

TGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAA AACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGC

TGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCC

TGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTA

TATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTT

ACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTC

TCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGT

TTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAG

CATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGC

GTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAA

TGAATCGGCCAACGCGCGGGGA (SEQ ID NO: 145)

[00518] Construct 222

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCT

CTGCCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATT

CTTCGAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACT

CCAAACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTG

TGCATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAAC

AAGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTTTTCCA

CACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGT

CAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAA

AATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCC

AAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATT

CCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAA

CGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGC

AACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTG

GTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGC

AGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATA

AGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTC

AGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTA

ACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGC

ATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCT

CTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCA

TCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATT ATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCC

AGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACC

ATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTG

CTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAG

CGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATG

GAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGG

TATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCT

CACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGA

TACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGG

AAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTT

GGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGA

CAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAAATCCTGC

ACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAG

GCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAACGGAA

TTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGA

AGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTT

TCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCT

GGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCT

CTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTA

TTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGT

TGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTAT

TCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTA

_{TTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTC}

CTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCT

CGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTG

TTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGC

CTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCC

GCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCG

CGGGGA (SEQ ID NO: 146)

[00519] Construct 223

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACG

TGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACG

TGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGC

AGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGG CCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTT

GAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCC

GAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCG

ACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAG

CACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTG

CCTCCTGTGGCCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCAAGTTCACC

ATAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACC

ATTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGC

CTTACAAGTCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGAT

GTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAG

TATATAACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAA

GCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAA

GTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCC

TCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATC

AACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGC

ATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACAT

CACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGG

GTTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCA

ATACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCT

GATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTA

TCTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAG

GATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTT

CCAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTC

CTGCTTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAG

AGTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACT

ACCACAGAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATT

GGACCCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGA

TTGGACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTT

CGAACATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTA

_{TTTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGT}

TCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATT

GGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACAC

CAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACT CAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCAT

GCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAA

AAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGC

TGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCAC

TGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGC

ATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAA

_{TTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACAT}

CAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCA

TGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTG

TCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTT

TGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTA

GCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTT

ATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCC

TGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATA

AAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGC

GCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAAT

CGGCCAACGCGCGGGGA (SEQ ID NO: 147)

[00520] Construct 225

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCC

CTACGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGC

CCTAATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCC

CTCTCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCG

TGGACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCA

CCAAGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAG

AACAACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGAT

ATCTGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTA

ATTGCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGC

TGGTTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCG

ATACAGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGT

ATTTCGACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCT

GAAAAACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTT

CATGCCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAA CTACATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCC

CTGAACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTAC

GCCATCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATC

GCCACACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACA

GCGGTGGGAGCGGCGGGAGCGGCGGTAGCAAGTTCACCATAGTTTTTCCACACA

ACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAG

CTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATG

CCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAAT

GGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCAT

CCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAA

ACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACT

GTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTG

ATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCA

ATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGT

CAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAG

GACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTAC

TTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGG

GGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTG

CTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCA

GACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCC

CTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTG

GATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAA

TCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGC

TCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGA

ACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGT

TCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATG

TTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACA

TTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACT

GGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAA

AGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTT

CTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAG

ATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAAATCCTGCACA

ACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCC TCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAACGGAATTC

CTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAG

GTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTC

CCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGG

CTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCT

CACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATT

TGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTG

GCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTC

CATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTT

TTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTC

CTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGA

CGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTAT

CCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGG

GGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTT

TCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGG

GGA (SEQ ID NO: 148)

[00521] Construct 226

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGC

CAGGCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGC

AAGCTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGG

TGCACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGA

GTGGAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGA

CCCTGCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCT

GTCCAGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCT

GCAGAGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAA

GGACCCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGG

TTTCTGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCA

CCGCCGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAG

AACGAGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTC

TGGTCTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAA

CCAGACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGA

GCTGCTGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGG AGCTCCTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCT

GCAACCTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTG

TTTCCTCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCC

TGACCCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTAC

ACACACAGCCAGAACCTGTCTCAGGAGGGCAGCGGTGGGAGCGGCGGGAGCGG

CGGTAGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAA

TGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATG

ACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGTCACAAGGCTATTC

AAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCG

CTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTCACTCCATCTGTA

GAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCC

AGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTG

ATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGG

TTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCA

TAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAAC

CTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGG

GAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCA

AGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTG

TCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATG

CCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTA

ATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCA

AAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAA

AAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATACTTT

GAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCG

GAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGATGACTGGGCACCAT

ATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGATATA

AGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGATCTTCATCTTAGC

TCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAACTTC

CTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGA

GCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTA

TCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGC

ATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAAC

CGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAA TCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTT

TATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCA

CTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCT

GGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATC

ATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTG

CAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGC

AAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCC

CATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATG

AAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTT

AGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTC

CTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAG

CTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCAT

GTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATA

CGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTC

ACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCC

AGCTGCATTAATGAATCGGCCAACGCGCGGGGA (SEQ ID NO: 149)

[00522] Construct 227

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACT

GCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACC

AACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATG

ATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCA

GCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCA

GCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACA

TCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAA

AGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAAT

CTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCT

GATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTG

ACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCA

GCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGG

CCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCT

CTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAG

ATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATT

TCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCAAGTTCACCATAG

TTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTA TTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTA

CAAGTCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGT

CATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATA

TAACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCAT

TGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTG

TGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCAC

CATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACG

GAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTC

TGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACC

TTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTC

AGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATAC

TGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATA

AGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTC

TGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATC

TTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAA

TCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGC

TTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTC

GATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCA

CAGAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGAC

CCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGG

ACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAA

CATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTT

TGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGT

AGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACT

ATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAG

AAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAAA

TCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTC

AAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAA

ACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCT

ATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAG

ATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCT

GACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTT

TGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGA ATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAA

CAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCAT

TCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTT

GTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGA

TTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAG

ATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTG

AAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTG

TAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCA

CTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCC

AACGCGCGGGGA (SEQ ID NO: 150)

[00523] Construct 228

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAGGGCATCTGC

AGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTG

CCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCC

AGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGCGATTCTCTGACAGATC

TGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCG

ACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGGAGGAGAACAGCT

CCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTG

AGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGT GGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGAT

AGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGTG

GGAGCGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTTTTCCACACAACCAAA

AAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGA

TTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAG

AGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCA

CTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATC

CTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGG

AACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACG

GATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAAT

ACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACA

TATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGG

GCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGA

GAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCT

TATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTC

AGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAG

CCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTC

AGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGC

CAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTC

AGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATG

GTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAAT

CCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTG

GGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAG

GACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGAC

TCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAG

ACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTA

TCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTA

TTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAG

TTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATAC

AGACATAGAGATGAACCGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTC

TTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTAT

ATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGA

TCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTG GTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAA

AAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGG

AAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAG

GACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAG

TTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGA

GGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAG

CCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAAC

ATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACT

ACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCC

GCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAA

TTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAAT

GAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGG

AAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGG

TTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCG

TTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCAC

AGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGG

CCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCC

TGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGG

ACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTT

CCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGG

CGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCC

AAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCG

GTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGC

AGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTT

CTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGC

GCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCA

AACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCG

CAGAAAAAAAAGGATCTCAA (SEQ ID NO: 151)

[00524] Construct 229

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGAAGTGCCTTTTGTACTT

AGCCTTTTTATTCATTGGGGTGAATTGCAAAAAAACCCAGACCTGGATCCTGACA

TGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCT

GCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATC

TGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCC

CAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGA

TCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATC

GACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGC

TCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCT

GAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGG

TGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGA

TAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCC

CTTAGAAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGAT

AGCAGCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCG

GCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGG

CCGTGGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGG

AGAAGGAACGGGAATTTCAGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGG

AGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTT

CCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTT

AATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGTCACAAGGCTATTCAAGC

AGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGG

TATGGACCGAAGTATATAACACATTCCATCCGATCCTTCACTCCATCTGTAGAAC

AATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCT

TCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGT CCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGAT

TCACAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACT

CTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCAT

TTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAG

GAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCC

TGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGG

TTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAG

AAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCA

GGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAAT

CAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAAC

CCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATACTTTGAGA

CCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAAT

GATCAGTGGAACTACCACAGAAGCGGAACTGTGGGATGACTGGGCACCATATGA

AGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTT

TCCTTTATACATGATTGGACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAA

AGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGA

TGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTT

GTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCAT

AGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTA

AATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGAC

TTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAA

CTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATG

AAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCT

CAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCT

CACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGA

AGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAAT

AGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAAT

CATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATA

TGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAAC

AGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGAT

_{TTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTA}

CATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGT

CCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTC ATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGA

GCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACA

TTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGC

TGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCT

CTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGC

GGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAA

CGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAA

AGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAA

AAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCA

GGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTA

CCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCA

CGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGC

ACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGA

GTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAG

GATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCC

TAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCA

GTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCT

GGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGA

TCTCAA (SEQ ID NO: 152)

[00525] Construct 230

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGAGGGCATCTGCAGAA

ATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCA

AGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCC

ACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCT

GGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAA

GCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAA

GGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGA

ATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCC

TCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCA

GAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGTGGGAG

CGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGG

AAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTA

AATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGT

CACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTA

CTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTT

CACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAAC

TTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGAT

GCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACA

CAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATAT

GCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCT

ATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAG

CTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATG

AAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGAC

TCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAG

ATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTG

GATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAG

AAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTA

TCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCT

CAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGATG

ACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCA

GTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGA

TCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCT GCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAA

AAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCC

TCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGT

ATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCA

TGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTT

GAGTTTTTAATTTTTATGAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGT

CGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGT

GGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAAT

TATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAAT

TTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACA

TATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGG

CAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTC

ATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTT

GACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATC

CCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACT

CCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCA

ATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTC

CACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAG

TGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAA

CCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTT

GCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTC

GGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAG

AATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCC

AGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTG

ACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGA

CTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTC

CGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGC

GCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCA

AGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGG

TAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCA

GCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTC

TTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCG CTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAA

ACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGC

AGAAAAAAAAGGATCTCAA (SEQ ID NO: 153)

[00526] Construct 232

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTACCAAAAGAGTG

CGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTACGAGGACGAGAGCACCTCCC

AGCACCCCTTCTACAACCCCGGCTTCATCAGCCCTAATGGCTTTACCCAAAGCCC

AGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTCTCACCACCACAGGCGGCTCC

CTGCAACTGAAGGTGGGCGGAGGACTGACCGTGGACGACACCGACGGCACACTG

CAGGAGAACATCAGAGCCACCGCCCCTATCACCAAGAACAACCACAGCGTGGAA

CTGAGCATCGGCAACGGCCTGGAAACCCAGAACAACAAGCTGTGCGCCAAGCTG

GGCAATGGCCTGAAGTTCAACAACGGAGATATCTGTATCAAGGACTCTATCAAC

ACCCTGTGGACCGGAATCAACCCTCCACCTAATTGCCAGATCGTGGAAAACACC

AATACCAACGACGGCAAGCTGACACTCGTGCTGGTTAAGAACGGAGGCCTGGTC AACGGCTACGTGTCCCTGGTCGGCGTGTCCGATACAGTGAACCAGATGTTCACAC

AGAAGACCGCTAATATTCAGCTGAGACTGTATTTCGACTCCAGTGGCAACCTGCT

GACAGAGGAATCTGACCTGAAAATCCCCCTGAAAAACAAGAGCAGCACCGCCAC

ATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATGCCTAGCACCACAGCTTATCCT

TTTAACACCACCACACGGGACAGCGAGAACTACATCCACGGCATCTGCTACTAC

ATGACCAGCTACGACAGAAGCCTGTTCCCCCTGAACATTAGCATCATGCTGAACA

GCAGGATGATCAGCAGCAACGTGGCTTACGCCATCCAGTTCGAGTGGAACCTGA

ACGCCAGCGAGAGCCCTGAGTCTAATATCGCCACACTGACCACATCTCCTTTTTT

CTTCAGCTACATCACCGAAGATGACAACAGCGGTGGGAGCGGCGGGAGCGGCGG

TAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGC

CAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAA

GAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTG

CGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCGGC

ATGCTGCCTGTGGCTGTGCTGGTGGCCCTGCTCGCCGTGATCGTGCTGGTCGCCC

TGCTGCTGCTGTGGCGGAGAAGACAGAAGAGACGGACCTAACTCAAATCCTGCA

CAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGG

CCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAACGGAATT

CCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAA

GGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTT

CCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTG

GCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTC

TCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTAT

TTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTT

GGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATT

CCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTAT

_{TTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCC}

TCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTC

GACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGT

TATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCC

TGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCG

CTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGC

GGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCG

CTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTA ATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAA

AGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCA

TAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTG

GCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCT

CGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCC

CTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGT

GTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGAC

CGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACT

TATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAG

GCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAA

CAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGG

TAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGC

AAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA (SEQ ID NO: 154)

[00527] Construct 233

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTACCAAAAGAGTG CGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTACGAGGACGAGAGCACCTCCC

AGCACCCCTTCTACAACCCCGGCTTCATCAGCCCTAATGGCTTTACCCAAAGCCC

AGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTCTCACCACCACAGGCGGCTCC

CTGCAACTGAAGGTGGGCGGAGGACTGACCGTGGACGACACCGACGGCACACTG

CAGGAGAACATCAGAGCCACCGCCCCTATCACCAAGAACAACCACAGCGTGGAA

CTGAGCATCGGCAACGGCCTGGAAACCCAGAACAACAAGCTGTGCGCCAAGCTG

GGCAATGGCCTGAAGTTCAACAACGGAGATATCTGTATCAAGGACTCTATCAAC

ACCCTGTGGACCGGAATCAACCCTCCACCTAATTGCCAGATCGTGGAAAACACC

AATACCAACGACGGCAAGCTGACACTCGTGCTGGTTAAGAACGGAGGCCTGGTC

AACGGCTACGTGTCCCTGGTCGGCGTGTCCGATACAGTGAACCAGATGTTCACAC

AGAAGACCGCTAATATTCAGCTGAGACTGTATTTCGACTCCAGTGGCAACCTGCT

GACAGAGGAATCTGACCTGAAAATCCCCCTGAAAAACAAGAGCAGCACCGCCAC

ATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATGCCTAGCACCACAGCTTATCCT

TTTAACACCACCACACGGGACAGCGAGAACTACATCCACGGCATCTGCTACTAC

ATGACCAGCTACGACAGAAGCCTGTTCCCCCTGAACATTAGCATCATGCTGAACA

GCAGGATGATCAGCAGCAACGTGGCTTACGCCATCCAGTTCGAGTGGAACCTGA

ACGCCAGCGAGAGCCCTGAGTCTAATATCGCCACACTGACCACATCTCCTTTTTT

CTTCAGCTACATCACCGAAGATGACAACAGCGGTGGGAGCGGCGGGAGCGGCGG

TAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGC

CAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAA

GAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTG

CGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCATC

GTGATCATCTCTAGCAGCCTGCTGCTGGGCCTGATCGTGCTGCTGCTGATCAGCT

ACGTGATGTGGAAGGCCGGCCTCTTCAAAAAACAGTACAAGTCCTAACTCAAAT

CCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCA

AAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAA

ACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCT

ATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAG

ATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCT

GACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTT

TGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGA

ATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAA

CAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCAT TCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTT

GTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGA

TTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAG

ATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTG

AAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTG

TAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCA

CTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCC

AACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCAC

TGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAG

GCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGA

GCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTT

TTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAG

AGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGC

TCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTT

TCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTT

CGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCC

CGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACAC

GACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTAT

GTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGA

AGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAG

TTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGT

TTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA (SEQ ID NO: 155)

[00528] Construct 234

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTACCAAAAGAGTG

CGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTACGAGGACGAGAGCACCTCCC

AGCACCCCTTCTACAACCCCGGCTTCATCAGCCCTAATGGCTTTACCCAAAGCCC

AGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTCTCACCACCACAGGCGGCTCC

CTGCAACTGAAGGTGGGCGGAGGACTGACCGTGGACGACACCGACGGCACACTG

CAGGAGAACATCAGAGCCACCGCCCCTATCACCAAGAACAACCACAGCGTGGAA

CTGAGCATCGGCAACGGCCTGGAAACCCAGAACAACAAGCTGTGCGCCAAGCTG

GGCAATGGCCTGAAGTTCAACAACGGAGATATCTGTATCAAGGACTCTATCAAC

ACCCTGTGGACCGGAATCAACCCTCCACCTAATTGCCAGATCGTGGAAAACACC

AATACCAACGACGGCAAGCTGACACTCGTGCTGGTTAAGAACGGAGGCCTGGTC

AACGGCTACGTGTCCCTGGTCGGCGTGTCCGATACAGTGAACCAGATGTTCACAC

AGAAGACCGCTAATATTCAGCTGAGACTGTATTTCGACTCCAGTGGCAACCTGCT

GACAGAGGAATCTGACCTGAAAATCCCCCTGAAAAACAAGAGCAGCACCGCCAC

ATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATGCCTAGCACCACAGCTTATCCT

TTTAACACCACCACACGGGACAGCGAGAACTACATCCACGGCATCTGCTACTAC

ATGACCAGCTACGACAGAAGCCTGTTCCCCCTGAACATTAGCATCATGCTGAACA

GCAGGATGATCAGCAGCAACGTGGCTTACGCCATCCAGTTCGAGTGGAACCTGA

ACGCCAGCGAGAGCCCTGAGTCTAATATCGCCACACTGACCACATCTCCTTTTTT

CTTCAGCTACATCACCGAAGATGACAACAGCGGTGGGAGCGGCGGGAGCGGCGG

TAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGC

CAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAA

GAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTG

CGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCCCT

CTGTTCATCCCCGTGGCCGTGATGGTGACCGCCTTCAGCGGCCTGGCTTTTATCAT

CTGGCTGGCCAGAAGACTGAAGAAGGGCAAGAAATCTAAGCGGTAACTCAAATC

CTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAA

AGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAACG GAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATC

AGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATC

TTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGAC

TTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGT

GTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATG

AGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAA

AGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCC

TTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGT

GTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATT

TTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGAT

CCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAA

ATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTA

AAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACT

GCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAA

CGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTG

ACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGC

GGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGC

AAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTT

CCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAG

GTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTC

CCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTC

TCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTC

GGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCC

GACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACG

ACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATG

TAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAA

GAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGT

TGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTT

TGCAAGCAGCAGATTACGCGCAGAAAAAAAAGGATCTCAA (SEQ ID NO: 156)

[00529] Construct 235

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTACCAAAAGAGTG

CGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTACGAGGACGAGAGCACCTCCC

AGCACCCCTTCTACAACCCCGGCTTCATCAGCCCTAATGGCTTTACCCAAAGCCC

AGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTCTCACCACCACAGGCGGCTCC

CTGCAACTGAAGGTGGGCGGAGGACTGACCGTGGACGACACCGACGGCACACTG

CAGGAGAACATCAGAGCCACCGCCCCTATCACCAAGAACAACCACAGCGTGGAA

CTGAGCATCGGCAACGGCCTGGAAACCCAGAACAACAAGCTGTGCGCCAAGCTG

GGCAATGGCCTGAAGTTCAACAACGGAGATATCTGTATCAAGGACTCTATCAAC

ACCCTGTGGACCGGAATCAACCCTCCACCTAATTGCCAGATCGTGGAAAACACC

AATACCAACGACGGCAAGCTGACACTCGTGCTGGTTAAGAACGGAGGCCTGGTC

AACGGCTACGTGTCCCTGGTCGGCGTGTCCGATACAGTGAACCAGATGTTCACAC

AGAAGACCGCTAATATTCAGCTGAGACTGTATTTCGACTCCAGTGGCAACCTGCT

GACAGAGGAATCTGACCTGAAAATCCCCCTGAAAAACAAGAGCAGCACCGCCAC

ATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATGCCTAGCACCACAGCTTATCCT

TTTAACACCACCACACGGGACAGCGAGAACTACATCCACGGCATCTGCTACTAC

ATGACCAGCTACGACAGAAGCCTGTTCCCCCTGAACATTAGCATCATGCTGAACA

GCAGGATGATCAGCAGCAACGTGGCTTACGCCATCCAGTTCGAGTGGAACCTGA

ACGCCAGCGAGAGCCCTGAGTCTAATATCGCCACACTGACCACATCTCCTTTTTT

CTTCAGCTACATCACCGAAGATGACAACAGCGGTGGGAGCGGCGGGAGCGGCGG

TAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGC CAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAA

GAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTG

CGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCCTG

CTGGCTATCCTGATCCTGGCCCTGGTCGCCACAATCTTCTTCGTGTGCACCGTGGT

GCTGGCCGTGAGACTGAGCAGAAAGGGCCACATGTACCCTGTGCGGAACTAACT

CAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCAT

GCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAA

AAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGC

TGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCAC

TGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGC

ATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAA

_{TTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACAT}

CAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCA

TGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTG

TCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTT

TGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTA

GCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTT

ATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCC

TGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATA

AAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGC

GCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAAT

CGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCG

CTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACT

CAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAAC

ATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCT

GGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCA

AGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCT

GGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGT

CCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTAT

CTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCG

TTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGT

AAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGC

GAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTA CACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGA

AAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGT

_{TTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAAGGATCTCAA (SEG ID}

NO: 157)

[00530] Construct 236

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTACCAAAAGAGTG

CGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTACGAGGACGAGAGCACCTCCC

AGCACCCCTTCTACAACCCCGGCTTCATCAGCCCTAATGGCTTTACCCAAAGCCC

AGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTCTCACCACCACAGGCGGCTCC

CTGCAACTGAAGGTGGGCGGAGGACTGACCGTGGACGACACCGACGGCACACTG

CAGGAGAACATCAGAGCCACCGCCCCTATCACCAAGAACAACCACAGCGTGGAA

CTGAGCATCGGCAACGGCCTGGAAACCCAGAACAACAAGCTGTGCGCCAAGCTG

GGCAATGGCCTGAAGTTCAACAACGGAGATATCTGTATCAAGGACTCTATCAAC

ACCCTGTGGACCGGAATCAACCCTCCACCTAATTGCCAGATCGTGGAAAACACC

AATACCAACGACGGCAAGCTGACACTCGTGCTGGTTAAGAACGGAGGCCTGGTC

AACGGCTACGTGTCCCTGGTCGGCGTGTCCGATACAGTGAACCAGATGTTCACAC

AGAAGACCGCTAATATTCAGCTGAGACTGTATTTCGACTCCAGTGGCAACCTGCT GACAGAGGAATCTGACCTGAAAATCCCCCTGAAAAACAAGAGCAGCACCGCCAC

ATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATGCCTAGCACCACAGCTTATCCT

TTTAACACCACCACACGGGACAGCGAGAACTACATCCACGGCATCTGCTACTAC

ATGACCAGCTACGACAGAAGCCTGTTCCCCCTGAACATTAGCATCATGCTGAACA

GCAGGATGATCAGCAGCAACGTGGCTTACGCCATCCAGTTCGAGTGGAACCTGA

ACGCCAGCGAGAGCCCTGAGTCTAATATCGCCACACTGACCACATCTCCTTTTTT

CTTCAGCTACATCACCGAAGATGACAACAGCGGTGGGAGCGGCGGGAGCGGCGG

TAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGC

CAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAA

GAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTG

CGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCATC

GTGGGCATCATCGCCGGACTGGTGCTGTTCGGCGCCGTCATCACCGGCGCTGTGG

TGGCCGCCGTGATGTGGCGGAGAAAGTCTAGCGACAGAAAGGGCTAACTCAAAT

CCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCA

AAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAC

GGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTAT

CAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGAT

_{CTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGA}

CTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTG

TGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAAT

GAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACA

AAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTC

CTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGT

GTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATT

TTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGAT

CCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAA

ATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTA

AAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACT

GCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAA

CGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTG

ACTCGCTGCGCTCGGTCGTTCGGCTGCGGTGAGCGGTATCAGCTCACTCAAAGGC

GGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGC

AAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTT CCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAG

GTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTC

CCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTC

TCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTC

GGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCC

GACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACG

ACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATG

TAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAA

GAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGT

TGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTT

TGCAAGCAGCAGATTACGCGCAGAAAAAAAAGGATCTCAA (SEQ ID NO: 158)

[00531] Construct 237

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTACCAAAAGAGTG

CGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTACGAGGACGAGAGCACCTCCC

AGCACCCCTTCTACAACCCCGGCTTCATCAGCCCTAATGGCTTTACCCAAAGCCC

AGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTCTCACCACCACAGGCGGCTCC CTGCAACTGAAGGTGGGCGGAGGACTGACCGTGGACGACACCGACGGCACACTG

CAGGAGAACATCAGAGCCACCGCCCCTATCACCAAGAACAACCACAGCGTGGAA

CTGAGCATCGGCAACGGCCTGGAAACCCAGAACAACAAGCTGTGCGCCAAGCTG

GGCAATGGCCTGAAGTTCAACAACGGAGATATCTGTATCAAGGACTCTATCAAC

ACCCTGTGGACCGGAATCAACCCTCCACCTAATTGCCAGATCGTGGAAAACACC

AATACCAACGACGGCAAGCTGACACTCGTGCTGGTTAAGAACGGAGGCCTGGTC

AACGGCTACGTGTCCCTGGTCGGCGTGTCCGATACAGTGAACCAGATGTTCACAC

AGAAGACCGCTAATATTCAGCTGAGACTGTATTTCGACTCCAGTGGCAACCTGCT

GACAGAGGAATCTGACCTGAAAATCCCCCTGAAAAACAAGAGCAGCACCGCCAC

ATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATGCCTAGCACCACAGCTTATCCT

TTTAACACCACCACACGGGACAGCGAGAACTACATCCACGGCATCTGCTACTAC

ATGACCAGCTACGACAGAAGCCTGTTCCCCCTGAACATTAGCATCATGCTGAACA

GCAGGATGATCAGCAGCAACGTGGCTTACGCCATCCAGTTCGAGTGGAACCTGA

ACGCCAGCGAGAGCCCTGAGTCTAATATCGCCACACTGACCACATCTCCTTTTTT

CTTCAGCTACATCACCGAAGATGACAACAGCGGTGGGAGCGGCGGGAGCGGCGG

TAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGC

CAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAA

GAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTG

CGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCAAC

GTGGTGTGCGCCCTGGGCCTGACCGTGAGCCTGGTCGGCATCATCATTGGAACAA

TCTTCATCATCAAGGGCCTGAGAAAGAGCAACGCCGCTGAGCGGAGAGGCCCTC

TGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTG

ATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAA

AAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTG

CAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAA

TACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCC

TTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGT

TGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAA

AACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGC

TGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCC

TGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTA

TATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTT

ACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTC TCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGT

TTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAG

CATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGC

GTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAA

TGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTT

CCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGC

TCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAA

GAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGT

TGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACG

CTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCC

CCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATAC

CTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAG

GTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCC

CCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACC

CGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCA

GAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACG

GCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTT

CGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGG

TGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAAGGATCTCAA (SEQ ID NO: 159)

[00532] Construct 238

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTACCAAAAGAGTG

CGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTACGAGGACGAGAGCACCTCCC

AGCACCCCTTCTACAACCCCGGCTTCATCAGCCCTAATGGCTTTACCCAAAGCCC

AGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTCTCACCACCACAGGCGGCTCC

CTGCAACTGAAGGTGGGCGGAGGACTGACCGTGGACGACACCGACGGCACACTG

CAGGAGAACATCAGAGCCACCGCCCCTATCACCAAGAACAACCACAGCGTGGAA

CTGAGCATCGGCAACGGCCTGGAAACCCAGAACAACAAGCTGTGCGCCAAGCTG

GGCAATGGCCTGAAGTTCAACAACGGAGATATCTGTATCAAGGACTCTATCAAC

ACCCTGTGGACCGGAATCAACCCTCCACCTAATTGCCAGATCGTGGAAAACACC

AATACCAACGACGGCAAGCTGACACTCGTGCTGGTTAAGAACGGAGGCCTGGTC

AACGGCTACGTGTCCCTGGTCGGCGTGTCCGATACAGTGAACCAGATGTTCACAC

AGAAGACCGCTAATATTCAGCTGAGACTGTATTTCGACTCCAGTGGCAACCTGCT

GACAGAGGAATCTGACCTGAAAATCCCCCTGAAAAACAAGAGCAGCACCGCCAC

ATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATGCCTAGCACCACAGCTTATCCT

TTTAACACCACCACACGGGACAGCGAGAACTACATCCACGGCATCTGCTACTAC

ATGACCAGCTACGACAGAAGCCTGTTCCCCCTGAACATTAGCATCATGCTGAACA

GCAGGATGATCAGCAGCAACGTGGCTTACGCCATCCAGTTCGAGTGGAACCTGA

ACGCCAGCGAGAGCCCTGAGTCTAATATCGCCACACTGACCACATCTCCTTTTTT

CTTCAGCTACATCACCGAAGATGACAACAGCGGTGGGAGCGGCGGGAGCGGCGG

TAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGC

CAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAA

GAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTG

CGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCATC

GTGATCATCACCGTGGTCGCCGCCGCTGTGATCATGGGCACAGCCGGCCTGAGC

ACCTACCTGTACAACAGACAGAGAAAGATCAAGAAATACCGGCTGTAACTCAAA

TCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTC

AAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAC

GGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTAT

CAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGAT _{CTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGA}

CTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTG

TGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAAT

GAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACA

AAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTC

CTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGT

GTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATT

TTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGAT

CCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAA

ATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTA

AAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACT

GCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAA

CGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTG

ACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGC

GGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGC

AAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTT

CCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAG

GTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTC

CCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTC

TCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTC

GGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCC

GACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACG

ACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATG

TAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAA

GAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGT

TGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTT

TGCAAGCAGCAGATTACGCGCAGAAAAAAAAGGATCTCAA (SEQ ID NO: 160)

[00533] Construct 240

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAACGCCAAGGTC

GTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCAGCGACGGGAAGCCCG

TCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGAAAGCCATGTTGCCAGAGC

CAACGTCAAGCATCTCAAAATTCTCAACACTCCAAACTGTGCCCTTCAGATTGTA

GCCCGGCTGAAGAACAACAACAGACAAGTGTGCATTGACCCGAAGCTAAAGTGG

ATTCAGGAGTACCTGGAGAAAGCTTTAAACAAGAGCGGTGGGAGCGGCGGGAG

CGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATC

GCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGC

ACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGG

CACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGG

AGCGGCATGCTGCCTGTGGCTGTGCTGGTGGCCCTGCTCGCCGTGATCGTGCTGG

TCGCCCTGCTGCTGCTGTGGCGGAGAAGACAGAAGAGACGGACCTAACTCAAAT

CCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCA

AAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAC

GGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTAT

CAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGAT

_{CTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGA}

CTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTG

TGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAAT

GAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACA

AAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTC CTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGT

GTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATT

TTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGAT

CCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAA

ATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTA

AAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACT

GCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAA

CGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTG

ACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGC

GGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGC

AAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTT

CCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAG

GTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTC

CCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTC

TCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTC

GGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCC

GACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACG

ACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATG

TAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAA

GAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGT

TGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTT

TGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA (SEQ ID NO: 161)

[00534] Construct 241

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAACGCCAAGGTC

GTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCAGCGACGGGAAGCCCG

TCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGAAAGCCATGTTGCCAGAGC

CAACGTCAAGCATCTCAAAATTCTCAACACTCCAAACTGTGCCCTTCAGATTGTA

GCCCGGCTGAAGAACAACAACAGACAAGTGTGCATTGACCCGAAGCTAAAGTGG

ATTCAGGAGTACCTGGAGAAAGCTTTAAACAAGAGCGGTGGGAGCGGCGGGAG

CGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATC

GCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGC

ACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGG

CACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGG

AGCATCGTGATCATCTCTAGCAGCCTGCTGCTGGGCCTGATCGTGCTGCTGCTGA

TCAGCTACGTGATGTGGAAGGCCGGCCTCTTCAAAAAACAGTACAAGTCCTAAC

TCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCA

TGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAA

AAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAG

GCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACC

ACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGA

GCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGG

AATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAAC

ATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGC

CATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGC

TGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATAT

TTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACT

AGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCT

TATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTC

CTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCAT

AAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTG CGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAA

TCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTC

GCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCAC

TCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAAC

ATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCT

GGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCA

AGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCT

GGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGT

CCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTAT

CTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCG

TTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGT

AAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGC

GAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTA

CACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGA

AAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGT

_{TTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA (SEQ ID} NO: 162)

[00535] Construct 242

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAACGCCAAGGTC

GTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCAGCGACGGGAAGCCCG

TCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGAAAGCCATGTTGCCAGAGC

CAACGTCAAGCATCTCAAAATTCTCAACACTCCAAACTGTGCCCTTCAGATTGTA

GCCCGGCTGAAGAACAACAACAGACAAGTGTGCATTGACCCGAAGCTAAAGTGG

ATTCAGGAGTACCTGGAGAAAGCTTTAAACAAGAGCGGTGGGAGCGGCGGGAG

CGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATC

GCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGC

ACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGG

CACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGG

AGCCCTCTGTTCATCCCCGTGGCCGTGATGGTGACCGCCTTCAGCGGCCTGGCTT

TTATCATCTGGCTGGCCAGAAGACTGAAGAAGGGCAAGAAATCTAAGCGGTAAC

TCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCA

TGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAA

AAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCT

GCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACT

GAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCA

TCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATT

TTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCA

GAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATG

AACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTC

CATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTG

TTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGC

CAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATG

GAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGT

GTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAA

GTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGC

TCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCG

GCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCT

CACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCA

AAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACAT GTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGG

CGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAG

TCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGG

AAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCG

CCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTC

AGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTC

AGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAG

ACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAG

GTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACT

AGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAA

GAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTT

TGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAAGGATCTCAA (SEQ ID NO: 163)

[00536] Construct 243

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAACGCCAAGGTC GTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCAGCGACGGGAAGCCCG

TCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGAAAGCCATGTTGCCAGAGC

CAACGTCAAGCATCTCAAAATTCTCAACACTCCAAACTGTGCCCTTCAGATTGTA

GCCCGGCTGAAGAACAACAACAGACAAGTGTGCATTGACCCGAAGCTAAAGTGG

ATTCAGGAGTACCTGGAGAAAGCTTTAAACAAGAGCGGTGGGAGCGGCGGGAG

CGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATC

GCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGC

ACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGG

CACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGG

AGCCTGCTGGCTATCCTGATCCTGGCCCTGGTCGCCACAATCTTCTTCGTGTGCAC

CGTGGTGCTGGCCGTGAGACTGAGCAGAAAGGGCCACATGTACCCTGTGCGGAA

CTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGA

TACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAA

AAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGT

GCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAA

ATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCC

CTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGT

GTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTT

AAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTG

GCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCC

CCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTT

TATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGT

TTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTC

TTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGC

TGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGG

AAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAAT

TGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCAT

TAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCC

GCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTAT

CAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAG

GAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCC

GCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATC

GACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGT TTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGA

TACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTG

TAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAA

CCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCA

ACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTA

GCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACT

ACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTAC

CTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAG

CGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA

(SEQ ID NO: 164)

[00537] Construct 244

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAACTTACAGAA

CTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGG

CTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACG

TGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGT

GCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGA

GACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGAT GGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTG

AGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAA

CTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTG

AGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTCTGATGCTGGTGGGCGGCT

CCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGCCGTGCCCAGCCGGACATC

TCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACGAGCGGCCTGCTGGAAACC

AACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGTCTGCTGAAATGGCAGCAG

GGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAGACATCTAGAAGCCTTGATC

AGATCCCTGGCTACCTGAACAGAATCCACGAGCTGCTGAACGGCACCAGAGGCC

TCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTCCTGATATCAGCAGCGGCAC

AAGCGACACCGGCAGCCTGCCACCTAACCTGCAACCTGGATATAGCCCCAGCCC

CACTCACCCCCCCACAGGCCAGTACACCCTGTTTCCTCTGCCTCCTACACTGCCA

ACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGACCCTAGCGCCCCTACCCCAA

CCCCCACCTCTCCTCTGCTGAATACCAGCTACACACACAGCCAGAACCTGTCTCA

GGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCC

CCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCC

CGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGC

GACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTC

TGGTGATCACCCTGTACTGCAGCGGTGGGAGCGGCATGCTGCCTGTGGCTGTGCT

GGTGGCCCTGCTCGCCGTGATCGTGCTGGTCGCCCTGCTGCTGCTGTGGCGGAGA

AGACAGAAGAGACGGACCTAACTCAAATCCTGCACAACAGATTCTTCATGTTTG

GACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTT

TTAATTTTTATGAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAG

GAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCA

ATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGG

GGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATT

TTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGG

GAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACA

TATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGT

ATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTG

AGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAA

ATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGT

CATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGT AATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACA

ACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCT

AACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTC

GTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTAT

TGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGC

GGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAG

GGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAAC

CGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGC

ATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAA

GATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCT

GCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTC

ATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGG

CTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTAT

CGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTG

GTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGT

GGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCT

GAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAAC

CACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAA

AAAGGATCTCAA (SEQ ID NO: 165)

[00538] Construct 245

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAACTTACAGAA

CTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGG

CTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACG

TGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGT

GCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGA

GACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGAT

GGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTG

AGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAA

CTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTG

AGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTCTGATGCTGGTGGGCGGCT

CCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGCCGTGCCCAGCCGGACATC

TCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACGAGCGGCCTGCTGGAAACC

AACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGTCTGCTGAAATGGCAGCAG

GGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAGACATCTAGAAGCCTTGATC

AGATCCCTGGCTACCTGAACAGAATCCACGAGCTGCTGAACGGCACCAGAGGCC

TCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTCCTGATATCAGCAGCGGCAC

AAGCGACACCGGCAGCCTGCCACCTAACCTGCAACCTGGATATAGCCCCAGCCC

CACTCACCCCCCCACAGGCCAGTACACCCTGTTTCCTCTGCCTCCTACACTGCCA

ACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGACCCTAGCGCCCCTACCCCAA

CCCCCACCTCTCCTCTGCTGAATACCAGCTACACACACAGCCAGAACCTGTCTCA

GGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCC

CCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCC

CGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGC

GACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTC

TGGTGATCACCCTGTACTGCAGCGGTGGGAGCATCGTGATCATCTCTAGCAGCCT

GCTGCTGGGCCTGATCGTGCTGCTGCTGATCAGCTACGTGATGTGGAAGGCCGGC

CTCTTCAAAAAACAGTACAAGTCCTAACTCAAATCCTGCACAACAGATTCTTCAT

GTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTG

AGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATC CGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGT

GTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAA

ATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAA

ATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGA

CATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTT

GGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGG

TCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCC

TTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACAT

CCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTA

CTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCG

CAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAAT

TCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATG

AGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGA

AACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGT

TTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGT

TCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCAC

AGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGG

CCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCC

TGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGG

ACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTT

CCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGG

CGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCC

AAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCG

GTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGC

AGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTT

CTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGC

GCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCA

AACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCG

CAGAAAAAAAGGATCTCAA (SEQ ID NO: 166)

[00539] Construct 246

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAACTTACAGAA

CTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGG

CTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACG

TGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGT

GCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGA

GACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGAT

GGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTG

AGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAA

CTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTG

AGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTCTGATGCTGGTGGGCGGCT

CCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGCCGTGCCCAGCCGGACATC

TCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACGAGCGGCCTGCTGGAAACC

AACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGTCTGCTGAAATGGCAGCAG

GGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAGACATCTAGAAGCCTTGATC

AGATCCCTGGCTACCTGAACAGAATCCACGAGCTGCTGAACGGCACCAGAGGCC

TCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTCCTGATATCAGCAGCGGCAC

AAGCGACACCGGCAGCCTGCCACCTAACCTGCAACCTGGATATAGCCCCAGCCC

CACTCACCCCCCCACAGGCCAGTACACCCTGTTTCCTCTGCCTCCTACACTGCCA

ACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGACCCTAGCGCCCCTACCCCAA CCCCCACCTCTCCTCTGCTGAATACCAGCTACACACACAGCCAGAACCTGTCTCA

GGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCC

CCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCC

CGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGC

GACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTC

TGGTGATCACCCTGTACTGCAGCGGTGGGAGCCCTCTGTTCATCCCCGTGGCCGT

GATGGTGACCGCCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGAAGACTG

AAGAAGGGCAAGAAATCTAAGCGGTAACTCAAATCCTGCACAACAGATTCTTCA

TGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTT

GAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCC

GTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGT

GTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAA

ATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAA

ATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGA

CATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTT

GGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGG

TCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCC

TTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACAT

CCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTA

CTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCG

CAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAAT

TCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATG

AGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGA

AACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGT

TTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGT

TCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCAC

AGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGG

CCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCC

TGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGG

ACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTT

CCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGG

CGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCC

AAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCG GTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGC

AGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTT

CTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGC

GCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCA

AACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCG

CAGAAAAAAAAGGATCTCAA (SEQ ID NO: 167)

[00540] Construct 247

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAACTTACAGAA

CTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGG

CTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACG

TGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGT

GCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGA

GACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGAT

GGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTG

AGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAA CTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTG

AGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTCTGATGCTGGTGGGCGGCT

CCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGCCGTGCCCAGCCGGACATC

TCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACGAGCGGCCTGCTGGAAACC

AACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGTCTGCTGAAATGGCAGCAG

GGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAGACATCTAGAAGCCTTGATC

AGATCCCTGGCTACCTGAACAGAATCCACGAGCTGCTGAACGGCACCAGAGGCC

TCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTCCTGATATCAGCAGCGGCAC

AAGCGACACCGGCAGCCTGCCACCTAACCTGCAACCTGGATATAGCCCCAGCCC

CACTCACCCCCCCACAGGCCAGTACACCCTGTTTCCTCTGCCTCCTACACTGCCA

ACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGACCCTAGCGCCCCTACCCCAA

CCCCCACCTCTCCTCTGCTGAATACCAGCTACACACACAGCCAGAACCTGTCTCA

GGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCC

CCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCC

CGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGC

GACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTC

TGGTGATCACCCTGTACTGCAGCGGTGGGAGCCTGCTGGCTATCCTGATCCTGGC

CCTGGTCGCCACAATCTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAGACTGAGC

AGAAAGGGCCACATGTACCCTGTGCGGAACTAACTCAAATCCTGCACAACAGAT

TCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATT

ATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAG

GGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTG

GCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTG

CCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATA

AAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCG

GAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTT

AGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATA

AAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGA

AAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCT

TTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCC

TGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATC

GGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTC

ACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCC TAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGT

CGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAG

GCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCG

GTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTAT

CCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAA

AAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGC

CCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCG

ACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTC

CTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGC

GTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTC

GCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTT

ATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTG

GCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACA

GAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTA

TCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATC

CGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATT

ACGCGCAGAAAAAAAAGGATCTCAA (SEQ ID NO: 168)

[00541] Construct 248

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAACTTACAGAA

CTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGG

CTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACG

TGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGT

GCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGA

GACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGAT

GGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTG

AGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAA

CTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTG

AGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTCTGATGCTGGTGGGCGGCT

CCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGCCGTGCCCAGCCGGACATC

TCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACGAGCGGCCTGCTGGAAACC

AACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGTCTGCTGAAATGGCAGCAG

GGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAGACATCTAGAAGCCTTGATC

AGATCCCTGGCTACCTGAACAGAATCCACGAGCTGCTGAACGGCACCAGAGGCC

TCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTCCTGATATCAGCAGCGGCAC

AAGCGACACCGGCAGCCTGCCACCTAACCTGCAACCTGGATATAGCCCCAGCCC

CACTCACCCCCCCACAGGCCAGTACACCCTGTTTCCTCTGCCTCCTACACTGCCA

ACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGACCCTAGCGCCCCTACCCCAA

CCCCCACCTCTCCTCTGCTGAATACCAGCTACACACACAGCCAGAACCTGTCTCA

GGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCC

CCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCC

CGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGC

GACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTC

TGGTGATCACCCTGTACTGCAGCGGTGGGAGCATCGTGGGCATCATCGCCGGACT

GGTGCTGTTCGGCGCCGTCATCACCGGCGCTGTGGTGGCCGCCGTGATGTGGCGG

AGAAAGTCTAGCGACAGAAAGGGCTAACTCAAATCCTGCACAACAGATTCTTCA

TGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTT

GAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCC

GTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGT GTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAA

ATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAA

ATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGA

CATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTT

GGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGG

TCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCC

TTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACAT

CCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTA

CTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCG

CAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAAT

TCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATG

AGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGA

AACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGT

TTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGT

TCGGCTGCGGTGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCAC

AGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGG

CCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCC

TGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGG

ACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTT

CCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGG

CGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCC

AAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCG

GTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGC

AGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTT

CTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGC

GCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCA

AACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCG

CAGAAAAAAAAGGATCTCAA (SEQ ID NO: 169)

[00542] Construct 249

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAACTTACAGAA

CTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGG

CTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACG

TGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGT

GCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGA

GACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGAT

GGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTG

AGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAA

CTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTG

AGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTCTGATGCTGGTGGGCGGCT

CCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGCCGTGCCCAGCCGGACATC

TCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACGAGCGGCCTGCTGGAAACC

AACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGTCTGCTGAAATGGCAGCAG

GGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAGACATCTAGAAGCCTTGATC

AGATCCCTGGCTACCTGAACAGAATCCACGAGCTGCTGAACGGCACCAGAGGCC

TCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTCCTGATATCAGCAGCGGCAC

AAGCGACACCGGCAGCCTGCCACCTAACCTGCAACCTGGATATAGCCCCAGCCC

CACTCACCCCCCCACAGGCCAGTACACCCTGTTTCCTCTGCCTCCTACACTGCCA

ACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGACCCTAGCGCCCCTACCCCAA

CCCCCACCTCTCCTCTGCTGAATACCAGCTACACACACAGCCAGAACCTGTCTCA GGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCC

CCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCC

CGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGC

GACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTC

TGGTGATCACCCTGTACTGCAGCGGTGGGAGCAACGTGGTGTGCGCCCTGGGCCT

GACCGTGAGCCTGGTCGGCATCATCATTGGAACAATCTTCATCATCAAGGGCCTG

AGAAAGAGCAACGCCGCTGAGCGGAGAGGCCCTCTGTAACTCAAATCCTGCACA

ACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCC

TCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAACGGAATTCCT

CGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGT

GGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCC

TCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCT

AATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCA

CTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTG

GTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGC

TATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCA

TAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTT

TTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCT

CTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACG

GATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCC

GCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGG

TGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTC

CAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGG

AGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGC

GCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATAC

GGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGC

CAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGG

CTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGA

AACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGC

GCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCG

GGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGG

TCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTG

CGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCG CCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGT

GCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTA

TTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCT

CTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCA

GCAGATTACGCGCAGAAAAAAAAGGATCTCAA (SEQ ID NO: 170)

[00543] Construct 250

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAACTTACAGAA

CTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGG

CTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACG

TGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGT

GCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGA

GACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGAT

GGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTG

AGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAA

CTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTG AGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTCTGATGCTGGTGGGCGGCT

CCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGCCGTGCCCAGCCGGACATC

TCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACGAGCGGCCTGCTGGAAACC

AACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGTCTGCTGAAATGGCAGCAG

GGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAGACATCTAGAAGCCTTGATC

AGATCCCTGGCTACCTGAACAGAATCCACGAGCTGCTGAACGGCACCAGAGGCC

TCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTCCTGATATCAGCAGCGGCAC

AAGCGACACCGGCAGCCTGCCACCTAACCTGCAACCTGGATATAGCCCCAGCCC

CACTCACCCCCCCACAGGCCAGTACACCCTGTTTCCTCTGCCTCCTACACTGCCA

ACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGACCCTAGCGCCCCTACCCCAA

CCCCCACCTCTCCTCTGCTGAATACCAGCTACACACACAGCCAGAACCTGTCTCA

GGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCC

CCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCC

CGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGC

GACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTC

TGGTGATCACCCTGTACTGCAGCGGTGGGAGCATCGTGATCATCACCGTGGTCGC

CGCCGCTGTGATCATGGGCACAGCCGGCCTGAGCACCTACCTGTACAACAGACA

GAGAAAGATCAAGAAATACCGGCTGTAACTCAAATCCTGCACAACAGATTCTTC

ATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATT

TGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCG

TCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGT

GGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAAT

TATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAAT

TTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACA

TATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGG

CAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTC

ATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTT

GACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATC

CCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACT

CCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCA

ATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTC

CACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAG

TGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAA CCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTT

GCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTC

GGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAG

AATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCC

AGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTG

ACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGA

CTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTC

CGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGC

GCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCA

AGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGG

TAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCA

GCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTC

TTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCG

CTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAA

ACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGC

AGAAAAAAAAGGATCTCAA (SEQ ID NO: 171)

[00544] Construct 251

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAACTTACAGAA

CTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGG

CTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACG

TGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGT

GCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGA

GACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGAT

GGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTG

AGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAA

CTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTG

AGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTCTGATGCTGGTGGGCGGCT

CCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGCCGTGCCCAGCCGGACATC

TCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACGAGCGGCCTGCTGGAAACC

AACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGTCTGCTGAAATGGCAGCAG

GGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAGACATCTAGAAGCCTTGATC

AGATCCCTGGCTACCTGAACAGAATCCACGAGCTGCTGAACGGCACCAGAGGCC

TCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTCCTGATATCAGCAGCGGCAC

AAGCGACACCGGCAGCCTGCCACCTAACCTGCAACCTGGATATAGCCCCAGCCC

CACTCACCCCCCCACAGGCCAGTACACCCTGTTTCCTCTGCCTCCTACACTGCCA

ACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGACCCTAGCGCCCCTACCCCAA

CCCCCACCTCTCCTCTGCTGAATACCAGCTACACACACAGCCAGAACCTGTCTCA

GGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCC

CCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCC

CGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGC

GACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTC

TGGTGATCACCCTGTACTGCAGCGGTGGGAGCTACCTGTACGTGCTGAGCGGCAT

CGGCGGACTGCTGCTGCTGCTCCTGATCTTCATCGTGCTGTACAAGGTGGGCTTT

TTCAAAAGAAACCTGAAGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGG ACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTT

TAATTTTTATGAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGA

ATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAAT

GCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGG

ACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTT

CATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGG

AGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACAT

ATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGT

ATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTG

AGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAA

ATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGT

CATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGT

AATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACA

ACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCT

AACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTC

GTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTAT

TGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGC

GGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAG

GGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAAC

CGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGC

ATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAA

GATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCT

GCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTC

ATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGG

CTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTAT

CGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTG

GTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGT

GGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCT

GAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAAC

CACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAA

AAAAGGATCTCAA (SEQ ID NO: 172)

[00545] Construct 252

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAACTTACAGAA

CTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGG

CTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACG

TGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGT

GCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGA

GACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGAT

GGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTG

AGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAA

CTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTG

AGCTTCCAGCACCTGCTGCGGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACC

ACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTC

TGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCT

GGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTG

CTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCGGCATGCTGC

CTGTGGCTGTGCTGGTGGCCCTGCTCGCCGTGATCGTGCTGGTCGCCCTGCTGCT

GCTGTGGCGGAGAAGACAGAAGAGACGGACCTAACTCAAATCCTGCACAACAG

ATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAA

TTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAACGGAATTCCTCGA GGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGT

GGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCT

GCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAAT

AAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTC

GGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTT

TAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTAT

AAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAG

AAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTC

TTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTC

CTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGAT

CGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCT

CACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGC

CTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAG

TCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGA

GGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTC

GGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTT

ATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGC

AAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCC

GCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACC

CGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTC

TCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAA

GCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGT

TCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCC

TTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCAC

TGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTA

CAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTG

GTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTG

ATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAG

ATTACGCGCAGAAAAAAAGGATCTCAA (SEQ ID NO: 173)

[00546] Construct 253

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAACTTACAGAA

CTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGG

CTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACG

TGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGT

GCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGA

GACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGAT

GGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTG

AGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAA

CTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTG

AGCTTCCAGCACCTGCTGCGGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACC

ACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTC

TGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCT

GGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTG

CTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCATCGTGATCA

TCTCTAGCAGCCTGCTGCTGGGCCTGATCGTGCTGCTGCTGATCAGCTACGTGAT

GTGGAAGGCCGGCCTCTTCAAAAAACAGTACAAGTCCTAACTCAAATCCTGCAC

AACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGC

CTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAAACGGAAT

TCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAA

GGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTT CCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTG

GCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTC

TCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTAT

TTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTT

GGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATT

CCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTAT

_{TTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCC}

TCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTC

GACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGT

TATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCC

TGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCG

CTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGC

GGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCG

CTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTA

ATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAA

AGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCA

TAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTG

GCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCT

CGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCC

CTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGT

GTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGAC

CGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACT

TATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAG

GCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAA

CAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGG

TAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGC

AAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA (SEQ ID NO: 174)

[00547] Construct 254

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAACTTACAGAA

CTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGG

CTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACG

TGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGT

GCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGA

GACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGAT

GGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTG

AGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAA

CTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTG

AGCTTCCAGCACCTGCTGCGGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACC

ACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTC

TGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCT

GGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTG

CTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCCTGCTGGCTA

TCCTGATCCTGGCCCTGGTCGCCACAATCTTCTTCGTGTGCACCGTGGTGCTGGCC

GTGAGACTGAGCAGAAAGGGCCACATGTACCCTGTGCGGAACTAACTCAAATCC

TGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAA

GAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAACG

GAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATC

AGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATC

TTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGAC TTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGT

GTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATG

AGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAA

AGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCC

TTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGT

GTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATT

TTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGAT

CCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAA

ATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTA

AAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACT

GCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAA

CGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTG

ACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGC

GGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGC

AAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTT

CCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAG

GTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTC

CCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTC

TCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTC

GGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCC

GACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACG

ACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATG

TAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAA

GAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGT

TGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTT

TGCAAGCAGCAGATTACGCGCAGAAAAAAAAGGATCTCAA (SEQ ID NO: 175)

[00548] Construct 255

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAACTTACAGAA

CTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGG

CTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACG

TGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGT

GCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGA

GACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGAT

GGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTG

AGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAA

CTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTG

AGCTTCCAGCACCTGCTGCGGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACC

ACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTC

TGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCT

GGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTG

CTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCCCTCTGTTCAT

CCCCGTGGCCGTGATGGTGACCGCCTTCAGCGGCCTGGCTTTTATCATCTGGCTG

GCCAGAAGACTGAAGAAGGGCAAGAAATCTAAGCGGTAACTCAAATCCTGCACA

ACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCC

TCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAACGGAATTCC

TCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGG

TGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCC

CTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGC

TAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTC ACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTT

GGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGG

CTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCC

ATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTT

TTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCC

TCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGAC

GGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATC

CGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGG

GTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTT

CCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGG

GAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTG

CGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATA

CGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGG

CCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAG

GCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCG

AAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGT

GCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTT

CGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTA

GGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGC

TGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTAT

CGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCG

GTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAG

TATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAG

CTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAG

CAGCAGATTACGCGCAGAAAAAAAAGGATCTCAA (SEQ ID NO: 176)

[00549] Construct 256

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAACTTACAGAA

CTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGG

CTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACG

TGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGT

GCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGA

GACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGAT

GGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTG

AGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAA

CTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTG

AGCTTCCAGCACCTGCTGCGGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACC

ACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTC

TGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCT

GGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTG

CTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCATCGTGGGCA

TCATCGCCGGACTGGTGCTGTTCGGCGCCGTCATCACCGGCGCTGTGGTGGCCGC CGTGATGTGGCGGAGAAAGTCTAGCGACAGAAAGGGCTAACTCAAATCCTGCAC

AACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGC

CTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAACGGAATTC

CTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAG

GTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTC

CCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGG

CTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCT

CACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATT

TGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTG

GCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTC

CATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTT

TTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTC

CTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGA

CGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTAT

CCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGG

GGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTT

TCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGG

GGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCT

GCGCTCGGTCGTTCGGCTGCGGTGAGCGGTATCAGCTCACTCAAAGGCGGTAAT

ACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAG

GCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATA

GGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGC

GAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCG

TGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCT

TCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGT

AGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCG

CTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTA

TCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGC

GGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACA

GTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTA

GCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAA

GCAGCAGATTACGCGCAGAAAAAAAAGGATCTCAA (SEQ ID NO: 177) [00550] Construct 257

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAACTTACAGAA

CTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGG

CTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACG

TGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGT

GCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGA

GACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGAT

GGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTG

AGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAA

CTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTG

AGCTTCCAGCACCTGCTGCGGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACC

ACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTC

TGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCT

GGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTG

CTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCAACGTGGTGT GCGCCCTGGGCCTGACCGTGAGCCTGGTCGGCATCATCATTGGAACAATCTTCAT

CATCAAGGGCCTGAGAAAGAGCAACGCCGCTGAGCGGAGAGGCCCTCTGTAACT

CAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCAT

GCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAA

AAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTG

CCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTG

AGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCAT

CTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTT

TTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAG

AATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGA

ACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCC

ATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGT

TTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCC

AGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATG

GAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGT

GTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAA

GTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGC

TCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCG

GCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCT

CACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCA

AAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACAT

GTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGG

CGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAG

TCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGG

AAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCG

CCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTC

AGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTC

AGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAG

ACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAG

GTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACT

AGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAA

GAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTT TGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAAGGATCTCAA (SEQ ID NO:

178)

[00551] Construct 258

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAACTTACAGAA

CTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGG

CTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACG

TGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGT

GCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGA

GACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGAT

GGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTG

AGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAA

CTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTG

AGCTTCCAGCACCTGCTGCGGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACC

ACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTC

TGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCT GGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTG

CTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCATCGTGATCA

TCACCGTGGTCGCCGCCGCTGTGATCATGGGCACAGCCGGCCTGAGCACCTACCT

GTACAACAGACAGAGAAAGATCAAGAAATACCGGCTGTAACTCAAATCCTGCAC

AACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGC

CTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAACGGAATTCC

TCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGG

TGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCC

CTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGC

TAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTC

ACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTT

GGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGG

CTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCC

ATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTT

TTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCC

TCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGAC

GGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATC

CGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGG

GTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTT

CCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGG

GAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTG

CGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATA

CGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGG

CCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAG

GCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCG

AAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGT

GCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTT

CGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTA

GGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGC

TGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTAT

CGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCG

GTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAG

TATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAG CTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAG

CAGCAGATTACGCGCAGAAAAAAAAGGATCTCAA (SEQ ID NO: 179)

[00552] Construct 259

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAACTTACAGAA

CTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGCCCGG

CTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGCCACG

TGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCCCTGT

GCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGGAAGA

GACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCGTGAT

GGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACAGCTG

AGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGACCCAA CTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTTCCTG

AGCTTCCAGCACCTGCTGCGGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACC

ACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTC

TGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCT

GGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTG

CTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCTACCTGTACG

TGCTGAGCGGCATCGGCGGACTGCTGCTGCTGCTCCTGATCTTCATCGTGCTGTA

CAAGGTGGGCTTTTTCAAAAGAAACCTGAAGTAACTCAAATCCTGCACAACAGA

TTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAAT

TATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAACGGAATTCCTCGAGG

GATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGG

CTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGC

CAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAA

AGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGG

AAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTA

GAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAA

AGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAA

AAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTT

TAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCT

GACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATC

GGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTC

ACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCC

TAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGT

CGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAG

GCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCG

GTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTAT

CCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAA

AAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGC

CCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCG

ACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTC

CTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGC

GTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTC

GCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTT ATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTG

GCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACA

GAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTA

TCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATC

CGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATT

ACGCGCAGAAAAAAAAGGATCTCAA (SEQ ID NO: 180)

[00553] Construct 260

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAACGCCAAGGTC

GTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCAGCGACGGGAAGCCCG

TCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGAAAGCCATGTTGCCAGAGC

CAACGTCAAGCATCTCAAAATTCTCAACACTCCAAACTGTGCCCTTCAGATTGTA

GCCCGGCTGAAGAACAACAACAGACAAGTGTGCATTGACCCGAAGCTAAAGTGG

ATTCAGGAGTACCTGGAGAAAGCTTTAAACAAGAGCGGTGGGAGCGGCGGGAG

CGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATC

GCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGC ACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGG

CACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGG

AGCATCGTGGGCATCATCGCCGGACTGGTGCTGTTCGGCGCCGTCATCACCGGCG

CTGTGGTGGCCGCCGTGATGTGGCGGAGAAAGTCTAGCGACAGAAAGGGCTAAC

TCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCA

TGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAA

AAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGC

TGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCAC

TGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGC

ATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAA

_{TTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACAT}

CAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCA

TGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTG

TCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTT

TGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTA

GCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTT

ATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCC

TGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATA

AAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGC

GCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAAT

CGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCG

CTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGTGAGCGGTATCAGCTCACT

CAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAAC

ATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCT

GGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCA

AGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCT

GGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGT

CCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTAT

CTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCG

TTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGT

AAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGC

GAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTA

CACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGA AAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGT

_{TTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAAGGATCTCAA (SEQ ID}

NO: 181)

[00554] Construct 261

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAACGCCAAGGTC

GTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCAGCGACGGGAAGCCCG

TCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGAAAGCCATGTTGCCAGAGC

CAACGTCAAGCATCTCAAAATTCTCAACACTCCAAACTGTGCCCTTCAGATTGTA

GCCCGGCTGAAGAACAACAACAGACAAGTGTGCATTGACCCGAAGCTAAAGTGG

ATTCAGGAGTACCTGGAGAAAGCTTTAAACAAGAGCGGTGGGAGCGGCGGGAG

CGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATC

GCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGC

ACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGG

CACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGG

AGCAACGTGGTGTGCGCCCTGGGCCTGACCGTGAGCCTGGTCGGCATCATCATTG GAACAATCTTCATCATCAAGGGCCTGAGAAAGAGCAACGCCGCTGAGCGGAGAG

GCCCTCTGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAA

CTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATG

AAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTC

AGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTC

ACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAA

GCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATA

GTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATC

ATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATAT

GCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACA

GCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTT

TTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACA

TGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCC

CTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCAT

AGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGC

CGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATT

AATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTG

CATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCT

TCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGG

TATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACG

CAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAG

GCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAA

ATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGG

CGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACC

GGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCAC

GCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCA

CGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAG

TCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGG

ATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCT

AACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAG

TTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTG

GTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAAGGA

TCTCAA (SEQ ID NO: 182) [00555] Construct 262

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAACGCCAAGGTC

GTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCAGCGACGGGAAGCCCG

TCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGAAAGCCATGTTGCCAGAGC

CAACGTCAAGCATCTCAAAATTCTCAACACTCCAAACTGTGCCCTTCAGATTGTA

GCCCGGCTGAAGAACAACAACAGACAAGTGTGCATTGACCCGAAGCTAAAGTGG

ATTCAGGAGTACCTGGAGAAAGCTTTAAACAAGAGCGGTGGGAGCGGCGGGAG

CGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATC

GCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGC

ACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGG

CACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGG

AGCATCGTGATCATCACCGTGGTCGCCGCCGCTGTGATCATGGGCACAGCCGGCC

TGAGCACCTACCTGTACAACAGACAGAGAAAGATCAAGAAATACCGGCTGTAAC

TCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCA

TGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAA AAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCT

GCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACT

GAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCA

TCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATT

TTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCA

GAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATG

AACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTC

CATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTG

TTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGC

CAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATG

GAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGT

GTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAA

GTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGC

TCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCG

GCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCT

CACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCA

AAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACAT

GTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGG

CGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAG

TCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGG

AAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCG

CCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTC

AGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTC

AGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAG

ACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAG

GTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACT

AGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAA

GAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTT

TGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAAGGATCTCAA (SEQ ID NO: 183) [00556] Construct 263

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTAACGCCAAGGTC

GTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCAGCGACGGGAAGCCCG

TCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGAAAGCCATGTTGCCAGAGC

CAACGTCAAGCATCTCAAAATTCTCAACACTCCAAACTGTGCCCTTCAGATTGTA

GCCCGGCTGAAGAACAACAACAGACAAGTGTGCATTGACCCGAAGCTAAAGTGG

ATTCAGGAGTACCTGGAGAAAGCTTTAAACAAGAGCGGTGGGAGCGGCGGGAG

CGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATC

GCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGC

ACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGG

CACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGG

AGCTACCTGTACGTGCTGAGCGGCATCGGCGGACTGCTGCTGCTGCTCCTGATCT TCATCGTGCTGTACAAGGTGGGCTTTTTCAAAAGAAACCTGAAGTAACTCAAATC

CTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAA

AGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAACGG

AATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCA

GAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTT

TTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTT

CTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGT

CTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAG

TATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAG

GTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTT

ATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGT

TATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTT

TCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCC

CTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAAT

TGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAA

GCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGC

CCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACG

CGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGAC

TCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGG

TAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAA

AAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCC

ATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGT

GGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCC

TCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTC

CCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGG

TGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGA

CCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGAC

TTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTA

GGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGA

ACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTG

GTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTG

CAAGCAGCAGATTACGCGCAGAAAAAAAAGGATCTCAA (SEQ ID NO: 184) [00557] Construct 264

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGAGGGCATCTGCAGAA

ATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCA

AGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCC

ACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCT

GGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAA

GCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAA

GGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGA

ATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCC

TCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCA

GAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGTGGGAG

CGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGG

AAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTA

AATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGT

CACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTA

CTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTT

CACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAAC

TTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGAT

GCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACA

CAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATAT

GCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCT ATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAG

CTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATG

AAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGAC

TCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAG

ATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTG

GATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAG

AAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTA

TCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCT

CAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGATG

ACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCA

GTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGA

TCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCT

GCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAA

AAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCC

TCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGT

ATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCA

TGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTT

GAGTTTTTAATTTTTATGAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGT

CGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGT

GGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAAT

TATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAAT

TTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACA

TATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGG

CAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTC

ATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTT

GACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATC

CCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACT

CCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCA

ATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTC

CACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAG

TGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAA CCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTT

GCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTC

GGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAG

AATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCC

AGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTG

ACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGA

CTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTC

CGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGC

GCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCA

AGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGG

TAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCA

GCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTC

TTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCG

CTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAA

ACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGC

AGAAAAAAAAGGATCTCAA (SEQ ID NO: 185)

[00558] Construct 265

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGAGGGCATCTGCAGAA

ATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCA AGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCC

ACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCT

GGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAA

GCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGGAGGAGAACAGCTCCAA

GGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGA

ATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCC

TCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCA

GAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGTGGGAG

CGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGG

AAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTA

AATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGT

CACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTA

CTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTT

CACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAAC

TTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGAT

GCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACA

CAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATAT

GCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCT

ATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAG

CTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATG

AAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGAC

TCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAG

ATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTG

GATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAG

AAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTA

TCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCT

CAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGATG

ACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCA

GTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGA

TCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCT

GCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAA

AAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCC TCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGT

ATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCA

TGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTT

GAGTTTTTAATTTTTATGAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGT

CGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGT

GGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAAT

TATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAAT

TTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACA

TATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGG

CAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTC

ATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTT

GACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATC

CCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACT

CCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCA

ATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTC

CACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAG

TGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAA

CCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTT

GCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTC

GGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAG

AATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCC

AGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTG

ACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGA

CTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTC

CGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGC

GCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCA

AGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGG

TAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCA

GCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTC

TTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCG

CTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAA ACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGC

AGAAAAAAAAGGATCTCAA (SEQ ID NO: 186)

[00559] Construct 266

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGAGGGCATCTGCAGAA

ATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCA

AGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCC

ACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCT

GGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAA

GCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGGAGGAGAACAGCTCCAA

GGACCGGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGA

ATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCC

TCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCA

GAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGTGGGAG

CGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGG

AAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTA

AATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGT

CACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTA

CTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTT

CACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAAC

TTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGAT GCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACA

CAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATAT

GCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCT

ATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAG

CTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATG

AAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGAC

TCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAG

ATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTG

GATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAG

AAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTA

TCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCT

CAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGATG

ACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCA

GTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGA

TCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCT

GCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAA

AAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCC

TCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGT

ATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAGTAACTCAAATCCTGCACAACAGATTCTTCA

TGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTT

GAGTTTTTAATTTTTATGAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGT

CGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGT

GGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAAT

TATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAAT

TTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACA

TATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGG

CAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTC

ATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTT

GACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATC

CCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACT

CCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCA ATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTC

CACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAG

TGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAA

CCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTT

GCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTC

GGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAG

AATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCC

AGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTG

ACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGA

CTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTC

CGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGC

GCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCA

AGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGG

TAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCA

GCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTC

TTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCG

CTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAA

ACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGC

AGAAAAAAAAGGATCTCAA (SEQ ID NO: 187)

[00560] Construct 267

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAGGGCATCTGC

AGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTG

CCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCC

AGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGAT

CTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCG

ACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCT

CCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTG

AGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGT

GGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGAT

AGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGTG

GGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACAC

CTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACC

CGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGG

GCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGT

ACTGCAGCGGTGGGAGCGGCATGCTGCCTGTGGCTGTGCTGGTGGCCCTGCTCGC

CGTGATCGTGCTGGTCGCCCTGCTGCTGCTGTGGCGGAGAAGACAGAAGAGACG

GACCTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTG

TGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAA

AAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGG

TGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACA

AATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCC

CCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGT

GTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTT

AAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTG

GCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCC

CCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTT

TATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGT

TTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTC TTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGC

TGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGG

AAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAAT

TGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCAT

TAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCC

GCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTAT

CAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAG

GAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCC

GCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATC

GACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGT

TTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGA

TACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTG

TAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAA

CCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCA

ACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTA

GCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACT

ACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTAC

CTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAG

CGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA

(SEQ ID NO: 188)

[00561] Construct 268

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAGGGCATCTGC

AGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTG

CCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCC

AGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGAT

CTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCG

ACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCT

CCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTG

AGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGT

GGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGAT

AGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGTG

GGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACAC

CTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACC

CGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGG

GCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGT

ACTGCAGCGGTGGGAGCCCTCTGTTCATCCCCGTGGCCGTGATGGTGACCGCCTT

CAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGAAGACTGAAGAAGGGCAAGAA

ATCTAAGCGGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATC

AACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTA

TGAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTC

CTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGG

CTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCAT

GAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCA

ATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAA

ATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCA

TATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAA

ACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAG

_{ATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCT} TACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCT

GTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATG

TCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATAC

GAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCA

CATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCA

GCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCG

CTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAG

CGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATA

ACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAA

AAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACA

AAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACC

AGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTT

ACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTC

ACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTG

CACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTG

AGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACA

GGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGC

CTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCC

AGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGC

TGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAAG

GATCTCAA (SEQ ID NO: 189)

[00562] Construct 269

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAGGGCATCTGC

AGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTG

CCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCC

AGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGAT

CTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCG

ACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCT

CCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTG

AGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGT

GGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGAT

AGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGTG

GGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACAC

CTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACC

CGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGG

GCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGT

ACTGCAGCGGTGGGAGCATCGTGATCATCTCTAGCAGCCTGCTGCTGGGCCTGAT

CGTGCTGCTGCTGATCAGCTACGTGATGTGGAAGGCCGGCCTCTTCAAAAAACA

GTACAAGTCCTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATC

AACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTA

TGAAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCA

CTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCT

GGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATC

ATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTG

CAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGC

AAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCC

CATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATG

AAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTT

AGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTC CTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAG

CTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCAT

GTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATA

CGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTC

ACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCC

AGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGC

GCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGA

GCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGAT

AACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAA

AAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCAC

AAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATAC

CAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCT

TACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCT

CACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGT

GCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTT

GAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAAC

AGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGG

CCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGC

CAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCG

CTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGG

ATCTCAA (SEQ ID NO: 190)

[00563] Construct 270

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAGGGCATCTGC

AGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTG

CCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCC

AGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGAT

CTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCG

ACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCT

CCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTG

AGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGT

GGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGAT

AGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGTG

GGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACAC

CTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACC

CGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGG

GCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGT

ACTGCAGCGGTGGGAGCATCGTGGGCATCATCGCCGGACTGGTGCTGTTCGGCG

CCGTCATCACCGGCGCTGTGGTGGCCGCCGTGATGTGGCGGAGAAAGTCTAGCG

ACAGAAAGGGCTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAAT

CAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTT

ATGAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACT

CCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTG

GCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCA

TGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGC

AATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCA

AATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCC

ATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGA

AACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTA GATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCC

TTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGC

TGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCAT

GTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATA

CGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTC

ACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCC

AGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGC

GCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGTGA

GCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGAT

AACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAA

AAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCAC

AAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATAC

CAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCT

TACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCT

CACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGT

GCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTT

GAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAAC

AGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGG

CCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGC

CAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCG

CTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAAG

GATCTCAA (SEQ ID NO: 191)

[00564] Construct 271

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAGGGCATCTGC

AGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTG

CCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCC

AGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGAT

CTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCG

ACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCT

CCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTG

AGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGT

GGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGAT

AGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGTG

GGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACAC

CTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACC

CGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGG

GCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGT

ACTGCAGCGGTGGGAGCAACGTGGTGTGCGCCCTGGGCCTGACCGTGAGCCTGG

TCGGCATCATCATTGGAACAATCTTCATCATCAAGGGCCTGAGAAAGAGCAACG

CCGCTGAGCGGAGAGGCCCTCTGTAACTCAAATCCTGCACAACAGATTCTTCATG

TTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGA

_{GTTTTTAATTTTTATGAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCG}

AGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGG

CCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTA

TGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTT

ATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATA

TGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCA

ACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCAT CAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGA

CTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCT

AAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCC

CAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAAT

TCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCA

CACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTG

AGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACC

TGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGC

GTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGG

CTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAA

TCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAG

GAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGAC

GAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTA

TAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGA

CCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTT

TCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGC

TGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAA

CTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCC

ACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTG

AAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTC

TGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAAC

AAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAG

AAAAAAAAGGATCTCAA (SEQ ID NO: 192)

[00565] Construct 272

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAGGGCATCTGC

AGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTG

CCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCC

AGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGAT

CTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCG

ACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCT

CCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTG

AGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGT

GGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGAT

AGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGTG

GGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACAC

CTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACC

CGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGG

GCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGT

ACTGCAGCGGTGGGAGCATCGTGATCATCACCGTGGTCGCCGCCGCTGTGATCAT

GGGCACAGCCGGCCTGAGCACCTACCTGTACAACAGACAGAGAAAGATCAAGA

AATACCGGCTGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAAT

CAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTT

ATGAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTC

CTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGG

CTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCAT

GAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCA

ATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAA

ATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCA TATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAA

ACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAG

_{ATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCT}

TACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCT

GTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATG

TCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATAC

GAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCA

CATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCA

GCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCG

CTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAG

CGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATA

ACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAA

AAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACA

AAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACC

AGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTT

ACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTC

ACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTG

CACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTG

AGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACA

GGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGC

CTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCC

AGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGC

TGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAAG

GATCTCAA (SEQ ID NO: 193)

[00566] Construct 273

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG

GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG

GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAGGGCATCTGC

AGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTG

CCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCC

AGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGAT

CTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCG

ACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCT

CCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTG

AGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGT

GGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGAT

AGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGTG

GGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACAC

CTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACC

CGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGG

GCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGT

ACTGCAGCGGTGGGAGCTACCTGTACGTGCTGAGCGGCATCGGCGGACTGCTGC

TGCTGCTCCTGATCTTCATCGTGCTGTACAAGGTGGGCTTTTTCAAAAGAAACCT

GAAGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTG

TGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAA

AAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGT GCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAA

ATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCC

CTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGT

GTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTT

AAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTG

GCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCC

CCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTT

TATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGT

TTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTC

TTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGC

TGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGG

AAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAAT

TGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCAT

TAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCC

GCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTAT

CAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAG

GAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCC

GCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATC

GACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGT

TTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGA

TACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTG

TAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAA

CCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCA

ACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTA

GCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACT

ACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTAC

CTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAG

CGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAAGGATCTCA

A (SEQ ID NO: 194)

[00567] Construct 274

GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCAC

GTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTT

AAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT

GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTC

GTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGG

CTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCT

CCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGT

CCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAG

TAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCAT

CGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGAT

CAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGG

TCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATG GCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGAC

TGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGC

TCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAA

GTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATC

TTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGC

AAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTT

CAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTG

AATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAG

TGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTT

AAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATC

AAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC

ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGG

CGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGC

CGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGG

GGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGG

GCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCG

CCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAA

CTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAA

AGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTC

ACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGG

CGAATTGGAGCTCCACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCAT

ACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACC

GCCATGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCA

TTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCC

CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGT

TCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTA

CGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCC

CTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGAC

CTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCA

TGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACG

GGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAA

AATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATG GGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAAC

CGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACC

GGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGG

GGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGG

GGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATG

GACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTC

CTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA

TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGC

CCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCGCTAGACCTGAGGGCATCTGC

AGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTG

CCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCC

AGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGAT

CTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCG

ACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCT

CCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTG

AGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGT

GGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGAT

AGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGTG

GGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACAC

CTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACC

CGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGG

GCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGT

ACTGCAGCGGTGGGAGCCTGCTGGCTATCCTGATCCTGGCCCTGGTCGCCACAAT

CTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAGACTGAGCAGAAAGGGCCACAT

GTACCCTGTGCGGAACTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGAC

CAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTA _{ATTTTTATGAAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGA}

ATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAAT

GCCCTGGCTCACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGG

ACATCATGAAGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTT

CATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGG

AGGGCAAATCATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACAT

ATGCCCATATGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGT

ATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTG

AGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAA

ATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGT

CATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGT

AATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACA

ACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCT

AACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTC

GTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTAT

TGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGC

GGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAG

GGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAAC

CGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGC

ATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAA

GATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCT

GCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTC

ATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGG

CTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTAT

CGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTG

GTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGT

GGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCT

GAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAAC

CACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAA

AAAAGGATCTCAA (SEQ ID NO: 195)

[00568] Construct pPHl

TCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTG

GAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAG

TTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCA

GCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATA

AGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAA

GCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAA

AAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATT

GTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATT

TTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGAC

CGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAAC GTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTA

CGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAA

ATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGA

ACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTG

GCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCG

CCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGG

CGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCT

GCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAA

ACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTC

CACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCAT

ATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACAT

TGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCC

CATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACC

GCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACG

CCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCC

ACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAA

TGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTT

CCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGT

TTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAG

TCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGAC

TTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTG

TACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTG

GAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAG

CCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGT

TCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAG

GGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAA

TTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTT

CATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAAT

TCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAG

GCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTAT

AATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAAT

ATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATG

GTTACAATGATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCG GGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAA

CGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCC

TCGAGGAATTCTGACACTATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGG

CCCTGCTGCTGCACGCCGCTAGACCTATGTTCAACATGCAGTGTCAGCGGAGATT

CTACGAGGCCCTGCACGACCCTAATCTGAACGAGGAACAGAGAAACGCCAAGAT

CAAGAGCATCAGAGATGACTGCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCA

CCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCC

TCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGC

CTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCG

TGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCTTCTGGGTCCTGGTTGTG

GTGGGCGGAGTGCTGGCCTGCTACAGCCTGCTGGTGACCGTGGCCTTTATCATTT

TCTGGGTGTGACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAA

CTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATG

AAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCC

TCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCT

CACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGA

AGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAAT

AGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAAT

CATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATA

TGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAAC

AGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGAT

_{TTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTA}

CATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGT

CCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTC

ATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGA

GCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACA

TTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGC

TGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCT

CTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGC

GGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAA

CGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAA

AGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAA

AAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCA GGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTA

CCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCA

CGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGC

ACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGA

GTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAG

GATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCC

TAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCA

GTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCT

GGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGA

TCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAA

ACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGAT

CCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACT

TGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTC

TATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACG

GGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTC

ACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAG

AAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAA

GCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTA

CAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCC

CAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGC

TCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCA

TGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTT

TCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGAC

CGAGTTGCTCTTGCCCGGCG (SEQ ID NO: 196)

[00569] Construct pPH2

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGAAGCCA

TCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCG

ACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTT

CGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTT

AGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTT

TCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGT

AACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGT

TTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGG

GTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATG

ATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATT

GGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAAT

GATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTC

TGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGG

TTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGA

ATTCTGACACTATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTG

CTGCACGCCGCTAGACCTATGTTCAACATGCAGTGTCAGCGGAGATTCTACGAGG

CCCTGCACGACCCTAATCTGAACGAGGAACAGAGAAACGCCAAGATCAAGAGCA

TCAGAGATGACTGCAGCGGTGGGAGCGGCGGGAGCCCCGGCCAACCTCGGGAAC

CCCAGGTGTACACCCTGCCTCCTAGCCAGGAGGAAATGACCAAGAACCAGGTGT

CCCTCACATGTCTGGTGAAGGGATTCTACCCCAGCGACATCGCCGTGGAATGGG

AGAGCAACGGCCAGCCTGAGAACAACTACAAGACCACCCCTCCAGTGCTGGACA

GCGATGGCAGCTTCTTTCTGTATAGCAGACTGACCGTGGACAAGTCCAGATGGCA GGAGGGCAATGTGTTCAGCTGCAGCGTGATGCACGAGGCTCTGCACAACCACTA

CACACAGAAATCTCTGAGCCTGTCTCTGGGCAAGTCTTTTTGGGTCCTGGTCGTG

GTGGGCGGAGTTCTGGCCTGCTACAGCCTGCTGGTGACAGTGGCCTTCATCATCT

TCTGGGTGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAA

CTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATG

AAAAAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCC

TCAGGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCT

CACAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGA

AGCCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAAT

AGTGTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAAT

CATTTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATA

TGCTGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAAC

AGCCCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGAT

_{TTTTTTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTA}

CATGTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGT

CCCTCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTC

ATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGA

GCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACA

TTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGC

TGCATTAATGAATCGGCCAACGCGCGGGGA (SEQ ID NO: 197)

[00570] Construct pPH3

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGAAGCCA

TCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCG

ACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTT

CGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTT

AGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTT

TCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGT

AACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGT

TTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGG

GTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATG

ATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATT

GGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAAT

GATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTC

TGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGG

TTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGA

ATTCTGACACTATGTTCAACATGCAGTGTCAGCGGAGATTCTACGAGGCCCTGCA

CGACCCTAATCTGAACGAGGAACAGAGAAACGCCAAGATCAAGAGCATCAGAG

ATGACTGCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCC

CCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCC

CGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGC

GACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTC

TGGTGATCACCCTGTACTGCAGCTTCTGGGTCCTGGTTGTGGTGGGCGGAGTGCT

GGCCTGCTACAGCCTGCTGGTGACCGTGGCCTTTATCATTTTCTGGGTGTGACTC

AAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATG

CTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAA

AAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCT

GCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACT

GAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCA

TCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATT TTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCA

GAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATG

AACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTC

CATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTG

TTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGC

CAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATG

GAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGT

GTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAA

GTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGC

TCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCG

GCCAACGCGCGGGGA (SEQ ID NO: 198)

[00571] Construct pPH4

AAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAA

TGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGA

ACCGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACA

CCGGGACCGATCCAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTG

GGGACCCTTGATTGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGG

GGGCAAAGTTTTCAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCAT

GGACCCTCATGATAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCT

CCTCTTATTTTCTTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGT

AACGAATTTTTAAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAA TCACTTTTTTTTCAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTA

GAGAACAATTGTTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCT

GGCTGGCGTGGAAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCC

TGCCTTTCTCTTTATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATA

CTCTGAGTCCAAACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCC

TACAGCTCCTGGGCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGA

ATTCCTCGACGGATCCCTCGAGGAATTCTGACACTATGTTCAACATGCAGTGTCA

GCGGAGATTCTACGAGGCCCTGCACGACCCTAATCTGAACGAGGAACAGAGAAA

CGCCAAGATCAAGAGCATCAGAGATGACTGCAGCGGTGGGAGCGGCGGGAGCG

GCGGTAGCCCCGGCCAACCTCGGGAACCCCAGGTGTACACCCTGCCTCCTAGCC

AGGAGGAAATGACCAAGAACCAGGTGTCCCTCACATGTCTGGTGAAGGGATTCT

ACCCCAGCGACATCGCCGTGGAATGGGAGAGCAACGGCCAGCCTGAGAACAACT

ACAAGACCACCCCTCCAGTGCTGGACAGCGATGGCAGCTTCTTTCTGTATAGCAG

ACTGACCGTGGACAAGTCCAGATGGCAGGAGGGCAATGTGTTCAGCTGCAGCGT

GATGCACGAGGCTCTGCACAACCACTACACACAGAAATCTCTGAGCCTGTCTCTG

GGCAAGTCTTTTTGGGTCCTGGTCGTGGTGGGCGGAGTTCTGGCCTGCTACAGCC

TGCTGGTGACAGTGGCCTTCATCATCTTCTGGGTGTGACTCAAATCCTGCACAAC

AGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTC

AATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAAAAAAACGGAATTCC

TCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCTGCCTATCAGAAGG

TGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACTGAGATCTTTTTCC

CTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTGACTTCTGGC

TAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTTGTGTCTCTC

ACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAATGAGTATTT

GGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAACAAAGGTTGG

CTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATTCCTTATTCC

ATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTTGTGTTATTTT

TTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGATTTTTCCTCC

TCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAGATCCCTCGAC

GGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGTGTGAAATTGTTATC

CGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGG

GTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTT

CCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGG GAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTG

CGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATA

CGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGG

CCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAG

GCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCG

AAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGT

GCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTT

CGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTA

GGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGC

TGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTAT

CGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCG

GTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAG

TATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAG

CTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAG

CAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTA

CGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGA

GATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAA

ATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATC

AGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACT

CCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCT

GCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAAC

CAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCC

ATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATA

GTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTT

GGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCC

CCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAG

TAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTT

ACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGT

CATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACG

GGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACG

TTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATG

TAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTC

TGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGA CACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTAT

CAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAAC

AAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTT

AATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCA

ATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGG

GTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCC

AACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCA

TCACCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACC

CTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGA

GAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTA

GCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAG

GGCGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTG

CGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGA

TTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCA

GTGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTG

GCGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATAT

GTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGA

CTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGA

GTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGAC

CCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGA

CTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGT

ACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAA

TGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGC

AGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTA

CATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCC

ATTGACGTCAATGGGAGTTTGTTTTGGCACC (SEQ ID NO: 199)

[00572] Construct pLV-20Nbarcode-CMV-EGFP-P2A-PuroR

AATGTAGTCTTATGCAATACTCTTGTAGTCTTGCAACATGGTAACGATGAGTTAG

CAACATGCCTTACAAGGAGAGAAAAAGCACCGTGCATGCCGATTGGTGGAAGTA AGGTGGTACGATCGTGCCTTATTAGGAAGGCAACAGACGGGTCTGACATGGATT

GGACGAACCACTGAATTCCGCATTGCAGAGATATTGTATTTAAGTGCCTAGCTCG

ATACAATAAACGCCATTTGACCATTCACCACATTGGTGTGCACCGGGTCTCTCTG

GTTAGACCAGATCTGAGCCTGGGAGCTCTCTGGCTAACTAGGGAACCCACTGCTT

AAGCCTCAATAAAGCTTGCCTTGAGTGCTTCAAGTAGTGTGTGCCCGTCTGTTGT

GTGACTCTGGTAACTAGAGATCCCTCAGACCCTTTTAGTCAGTGTGGAAAATCTC

TAGCAGTGGCGCCCGAACAGGGACTTGAAAGCGAAAGGGAAACCAGAGGAGCT

CTCTCGACGCAGGACTCGGCTTGCTGAAGCGCGCACGGCAAGAGGCGAGGGGCG

GCGACTGGTGAGTACGCCAAAAATTTTGACTAGCGGAGGCTAGAAGGAGAGAGA

TGGGTGCGAGAGCGTCAGTATTAAGCGGGGGAGAATTAGATCGCGATGGGAAAA

AATTCGGTTAAGGCCAGGGGGAAAGAAAAAATATAAATTAAAACATATAGTATG

GGCAAGCAGGGAGCTAGAACGATTCGCAGTTAATCCTGGCCTGTTAGAAACATC

AGAAGGCTGTAGACAAATACTGGGACAGCTACAACCATCCCTTCAGACAGGATC

AGAAGAACTTAGATCATTATATAATACAGTAGCAACCCTCTATTGTGTGCATCAA

AGGATAGAGATAAAAGACACCAAGGAAGCTTTAGACAAGATAGAGGAAGAGCA

AAACAAAAGTAAGACCACCGCACAGCAAGCGGCCGCTGATCTTCAGACCTGGAG

GAGGAGATATGAGGGACAATTGGAGAAGTGAATTATATAAATATAAAGTAGTAA

AAATTGAACCATTAGGAGTAGCACCCACCAAGGCAAAGAGAAGAGTGGTGCAG

AGAGAAAAAAGAGCAGTGGGAATAGGAGCTTTGTTCCTTGGGTTCTTGGGAGCA

GCAGGAAGCACTATGGGCGCAGCGTCAATGACGCTGACGGTACAGGCCAGACAA

TTATTGTCTGGTATAGTGCAGCAGCAGAACAATTTGCTGAGGGCTATTGAGGCGC

AACAGCATCTGTTGCAACTCACAGTCTGGGGCATCAAGCAGCTCCAGGCAAGAA

TCCTGGCTGTGGAAAGATACCTAAAGGATCAACAGCTCCTGGGGATTTGGGGTT

GCTCTGGAAAACTCATTTGCACCACTGCTGTGCCTTGGAATGCTAGTTGGAGTAA

TAAATCTCTGGAACAGATTTGGAATCACACGACCTGGATGGAGTGGGACAGAGA

AATTAACAATTACACAAGCTTAATACACTCCTTAATTGAAGAATCGCAAAACCA

GCAAGAAAAGAATGAACAAGAATTATTGGAATTAGATAAATGGGCAAGTTTGTG

GAATTGGTTTAACATAACAAATTGGCTGTGGTATATAAAATTATTCATAATGATA

GTAGGAGGCTTGGTAGGTTTAAGAATAGTTTTTGCTGTACTTTCTATAGTGAATA

GAGTTAGGCAGGGATATTCACCATTATCGTTTCAGACCCACCTCCCAACCCCGAG

GGGACCCGACAGGCCCGAAGGAATAGAAGAAGAAGGTGGAGAGAGAGACAGA

GACAGATCCATTCGATTAGTGAACGGATCGGCACTGCGTGCGCCAATTCTGCAG

ACAAATGGCAGTATTCATCCACAATTTTAAAAGAAAAGGGGGGATTGGGGGGTA CAGTGCAGGGGAAAGAATAGTAGACATAATAGCAACAGACATACAAACTAAAG

AATTACAAAAACAAATTACAAAAATTCAAAATTTTCGGGTTTATTACAGGGACA

GCAGAGATCCANNNNNNNNNNNNNNNNNNNNGTTTGGTTAATTAAGGTACCGA

CATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATA

GCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTG

ACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTA

ACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTG

CCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGT

CAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGAC

TTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCG

GTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCA

AGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGG

ACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGC

GTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCG

CCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATC

CAGCCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGAT

TGTTCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTT

CAGGGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGA

TAATTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTC

TTTTCATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTT

AAATTCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTT

CAAGGCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTG

TTATAATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGG

AAATATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTT

TATGGTTACAATGATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAA

ACCGGGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGG

GCAACGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGAGGG

CCGGATCCGAATTCCTGTATTTGTCTGAAAACATGGTGAGCAAGGGCGAGGAGC

TGTTCACCGGGGTGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCC

ACAAGTTCAGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGA

CCCTGAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGT

GACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAA

GCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCAC CATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGA

GGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGGA

CGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAACGTCTA

TATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAAGATCCGCCA

CAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACCAGCAGAACACCCC

CATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCACTACCTGAGCACCCAGTCC

GCCCTGAGCAAAGACCCCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTC

GTGACCGCCGCCGGGATCACTCTCGGCATGGACGAGCTGTACAAGGGATCCGGC

GCAACAAACTTCTCTCTGCTGAAACAAGCCGGAGATGTCGAAGAGAATCCTGGA

CCGACCGAGTACAAGCCCACGGTGCGCCTCGCCACCCGCGACGACGTCCCCAGG

GCCGTACGCACCCTCGCCGCCGCGTTCGCCGACTACCCCGCCACGCGCCACACCG

TCGATCCGGACCGCCACATCGAGCGGGTCACCGAGCTGCAAGAACTCTTCCTCAC

GCGCGTCGGGCTCGACATCGGCAAGGTGTGGGTCGCGGACGACGGCGCCGCGGT

GGCGGTCTGGACCACGCCGGAGAGCGTCGAAGCGGGGGCGGTGTTCGCCGAGAT

CGGCCCGCGCATGGCCGAGTTGAGCGGTTCCCGGCTGGCCGCGCAGCAACAGAT

GGAAGGCCTCCTGGCGCCGCACCGGCCCAAGGAGCCCGCGTGGTTCCTGGCCAC

CGTCGGAGTCTCGCCCGACCACCAGGGCAAGGGTCTGGGCAGCGCCGTCGTGCT

CCCCGGAGTGGAGGCGGCCGAGCGCGCCGGGGTGCCCGCCTTCCTGGAGACCTC

CGCGCCCCGCAACCTCCCCTTCTACGAGCGGCTCGGCTTCACCGTCACCGCCGAC

GTCGAGGTGCCCGAAGGACCGCGCACCTGGTGCATGACCCGCAAGCCCGGTGCC

TGAACGCGTTAAGTCGACAATCAACCTCTGGATTACAAAATTTGTGAAAGATTGA

CTGGTATTCTTAACTATGTTGCTCCTTTTACGCTATGTGGATACGCTGCTTTAATG

CCTTTGTATCATGCTATTGCTTCCCGTATGGCTTTCATTTTCTCCTCCTTGTATAAA

TCCTGGTTGCTGTCTCTTTATGAGGAGTTGTGGCCCGTTGTCAGGCAACGTGGCG

TGGTGTGCACTGTGTTTGCTGACGCAACCCCCACTGGTTGGGGCATTGCCACCAC

CTGTCAGCTCCTTTCCGGGACTTTCGCTTTCCCCCTCCCTATTGCCACGGCGGAAC

TCATCGCCGCCTGCCTTGCCCGCTGCTGGACAGGGGCTCGGCTGTTGGGCACTGA

CAATTCCGTGGTGTTGTCGGGGAAATCATCGTCCTTTCCTTGGCTGCTCGCCTGTG

TTGCCACCTGGATTCTGCGCGGGACGTCCTTCTGCTACGTCCCTTCGGCCCTCAAT

CCAGCGGACCTTCCTTCCCGCGGCCTGCTGCCGGCTCTGCGGCCTCTTCCGCGTCT

TCGCCTTCGCCCTCAGACGAGTCGGATCTCCCTTTGGGCCGCCTCCCCGCGTCGA

CTTTAAGACCAATGACTTACAAGGCAGCTGTAGATCTTAGCCACTTTTTAAAAGA

AAAGGGGGGACTGGAAGGGCTAATTCACTCCCAACGAAGACAAGATCTGCTTTT TGCTTGTACTGGGTCTCTCTGGTTAGACCAGATCTGAGCCTGGGAGCTCTCTGGC

TAACTAGGGAACCCACTGCTTAAGCCTCAATAAAGCTTGCCTTGAGTGCTTCAAG

TAGTGTGTGCCCGTCTGTTGTGTGACTCTGGTAACTAGAGATCCCTCAGACCCTTT

TAGTCAGTGTGGAAAATCTCTAGCAGGGCCCGTTTAAACCCGCTGATCAGCCTCG

ACTGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTT

GACCCTGGAAGGTGCCACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCA

TCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGTGGGGCAGGACA

GCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGC

TCTATGGCTTCTGAGGCGGAAAGAACCAGCTGGGGCTCTAGGGGGTATCCCCAC

GCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTG

ACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTT

TCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTA

GGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTG

ATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTT

GGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAAC

CCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTG

GTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATG

TGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGC

AAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCC

CAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCC

CGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCG

CCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTC

TGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAA

AAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAGCACGTGTTGACAA

TTAATCATCGGCATAGTATATCGGCATAGTATAATACGACAAGGTGAGGAACTA

AACCATGGCCAAGTTGACCAGTGCCGTTCCGGTGCTCACCGCGCGCGACGTCGCC

GGAGCGGTCGAGTTCTGGACCGACCGGCTCGGGTTCTCCCGGGACTTCGTGGAG

GACGACTTCGCCGGTGTGGTCCGGGACGACGTGACCCTGTTCATCAGCGCGGTCC

AGGACCAGGTGGTGCCGGACAACACCCTGGCCTGGGTGTGGGTGCGCGGCCTGG

ACGAGCTGTACGCCGAGTGGTCGGAGGTCGTGTCCACGAACTTCCGGGACGCCT

CCGGGCCGGCCATGACCGAGATCGGCGAGCAGCCGTGGGGGCGGGAGTTCGCCC

TGCGCGACCCGGCCGGCAACTGCGTGCACTTCGTGGCCGAGGAGCAGGACTGAC

ACGTGCTACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGG AATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTG

GAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAA

GCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGT

GGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAG

CTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGC

TCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTG

CCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCA

GTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAG

AGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCT

CGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGT

TATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAG

CAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTC

CGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAAC

CCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCT

CTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGA

AGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCG

TTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGC

CTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCA

CTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCT

ACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTT

GGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTT

GATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCA

GATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGG

GTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTA

TCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAA

TCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGA

GGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCG

TCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAAT

GATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCC

AGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCA

GTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTG

CGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTA

TGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCAT GTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAG

TTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGT

CATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTC

TGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGAT

AATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTT

CGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACC

CACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGT

GAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGG

AAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGG

TTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATA

GGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCGACGGATCGGGA

GATCTCCCGATCCCCTATGGTGCACTCTCAGTACAATCTGCTCTGATGCCGCATA

GTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCG

AGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAAT

CTGCTTAGGGTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGC

GTT SEQ ID NO: 534

[00573] Construct pLV-barcode-donor

CGACGGATCGGGAGATCTCCCGATCCCCTATGGTGCACTCTCAGTACAATCTGCT

CTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGC

TGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAA

TTGCATGAAGAATCTGCTTAGGGTTAGGCGTTTTGCGCTGCTTCGCGATGTACGG

GCCAGATATACGCGTTAATGTAGTCTTATGCAATACTCTTGTAGTCTTGCAACAT

GGTAACGATGAGTTAGCAACATGCCTTACAAGGAGAGAAAAAGCACCGTGCATG

CCGATTGGTGGAAGTAAGGTGGTACGATCGTGCCTTATTAGGAAGGCAACAGAC

GGGTCTGACATGGATTGGACGAACCACTGAATTCCGCATTGCAGAGATATTGTAT

TTAAGTGCCTAGCTCGATACAATAAACGCCATTTGACCATTCACCACATTGGTGT GCACCGGGTCTCTCTGGTTAGACCAGATCTGAGCCTGGGAGCTCTCTGGCTAACT

AGGGAACCCACTGCTTAAGCCTCAATAAAGCTTGCCTTGAGTGCTTCAAGTAGTG

TGTGCCCGTCTGTTGTGTGACTCTGGTAACTAGAGATCCCTCAGACCCTTTTAGTC

AGTGTGGAAAATCTCTAGCAGTGGCGCCCGAACAGGGACTTGAAAGCGAAAGGG

AAACCAGAGGAGCTCTCTCGACGCAGGACTCGGCTTGCTGAAGCGCGCACGGCA

AGAGGCGAGGGGCGGCGACTGGTGAGTACGCCAAAAATTTTGACTAGCGGAGGC

TAGAAGGAGAGAGATGGGTGCGAGAGCGTCAGTATTAAGCGGGGGAGAATTAG

ATCGCGATGGGAAAAAATTCGGTTAAGGCCAGGGGGAAAGAAAAAATATAAATT

AAAACATATAGTATGGGCAAGCAGGGAGCTAGAACGATTCGCAGTTAATCCTGG

CCTGTTAGAAACATCAGAAGGCTGTAGACAAATACTGGGACAGCTACAACCATC

CCTTCAGACAGGATCAGAAGAACTTAGATCATTATATAATACAGTAGCAACCCTC

TATTGTGTGCATCAAAGGATAGAGATAAAAGACACCAAGGAAGCTTTAGACAAG

ATAGAGGAAGAGCAAAACAAAAGTAAGACCACCGCACAGCAAGCGGCCGCTGA

TCTTCAGACCTGGAGGAGGAGATATGAGGGACAATTGGAGAAGTGAATTATATA

AATATAAAGTAGTAAAAATTGAACCATTAGGAGTAGCACCCACCAAGGCAAAGA

GAAGAGTGGTGCAGAGAGAAAAAAGAGCAGTGGGAATAGGAGCTTTGTTCCTTG

GGTTCTTGGGAGCAGCAGGAAGCACTATGGGCGCAGCGTCAATGACGCTGACGG

TACAGGCCAGACAATTATTGTCTGGTATAGTGCAGCAGCAGAACAATTTGCTGA

GGGCTATTGAGGCGCAACAGCATCTGTTGCAACTCACAGTCTGGGGCATCAAGC

AGCTCCAGGCAAGAATCCTGGCTGTGGAAAGATACCTAAAGGATCAACAGCTCC

TGGGGATTTGGGGTTGCTCTGGAAAACTCATTTGCACCACTGCTGTGCCTTGGAA

TGCTAGTTGGAGTAATAAATCTCTGGAACAGATTTGGAATCACACGACCTGGATG

GAGTGGGACAGAGAAATTAACAATTACACAAGCTTAATACACTCCTTAATTGAA

GAATCGCAAAACCAGCAAGAAAAGAATGAACAAGAATTATTGGAATTAGATAA

ATGGGCAAGTTTGTGGAATTGGTTTAACATAACAAATTGGCTGTGGTATATAAAA

TTATTCATAATGATAGTAGGAGGCTTGGTAGGTTTAAGAATAGTTTTTGCTGTAC

TTTCTATAGTGAATAGAGTTAGGCAGGGATATTCACCATTATCGTTTCAGACCCA

CCTCCCAACCCCGAGGGGACCCGACAGGCCCGAAGGAATAGAAGAAGAAGGTG

GAGAGAGAGACAGAGACAGATCCATTCGATTAGTGAACGGATCGGCACTGCGTG

CGCCAATTCTGCAGACAAATGGCAGTATTCATCCACAATTTTAAAAGAAAAGGG

GGGATTGGGGGGTACAGTGCAGGGGAAAGAATAGTAGACATAATAGCAACAGA

CATACAAACTAAAGAATTACAAAAACAAATTACAAAAATTCAAAATTTTCGGGT

TTATTACAGGGACAGCAGAGATCCAGCAGGTGTTAAGCACCGGTGGAGTGACGA CCTTCAGCACGTTCGTACTGTTCAACGATGGTGTAGTCTTCGTTGTGGGAGGTGA

TGTCCAGTTTGATGTCGGTTTTGTAAGCACCCGGCAGCTGAACCGGTTTTTTAGC

CATGTAGGTGGTTTTAACTTCAGCGTCGTAGTGACCACCGTCTTTCAGTTTCAGA

CGCATTTTGATTTCACCTTTCAGAGCACCGTCTTCCGGGTACATACGTTCGGTGG

AAGCTTCCCAACCCATGGTTTTTTTCTGCATAACCGGACCGTCGGACGGGAAGTT

GGTACCACGCAGTTTAACTTTGTAGATGAACTCACCGTCTTGCAGGGAGGAGTCC

TGGGTAACGGTAACAACACCACCGTCTTCGAAGTTCATAACACGTTCCCATTTGA

AACCTTCCGGGAAGGACAGTTTCAGGTAGTCCGGGATGTCAGCCGGGTGTTTAA

CGTAAGCTTTGGAACCGTACTGGAACTGCGGGGACAGGATGTCCCAAGCGAACG

GCAGCGGACCACCTTTGGTAACTTTCAGTTTAGCGGTCTGGGTACCTTCGTACGG

ACGACCTTCACCTTCACCTTCGATTTCGAACTCGTGACCGTTAACGGAACCTTCC

ATACGAACTTTGAAACGCATGAACTCTTTGATAACGTCTTCGCTACTCGCCATAG

ATCCTTTCTCCTCTTTCAGATCCGTGCTCAGTATCTCTATCACTGATAGGGATGTC

AATCTCTATCACTGATAGGGACACCTGCGTTTGGTTAATTAAGGTACCGACATTG

ATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCA

TATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGC

CCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCC

AATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCAC

TTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATG

ACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCC

TACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTT

GGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCT

CCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTT

CCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTA

CGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGG

AGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGC

CTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTT

CTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGG

GTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAAT

TTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTC

ATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATT

CACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGG

CAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATA ATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATA

TTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGG

TTACAATGATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGG

GCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAAC

GTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGAGGGCCGGA

TCCGAATTCCTGTATTTGTCTGAAAACATGGTGAGCAAGGGCGAGGAGCTGTTCA

CCGGGGTGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGT

TCAGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGA

AGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCAC

CCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCA

CGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGGCGAC

ACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGGACGGCAAC

ATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAACGTCTATATCATG

GCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAAGATCCGCCACAACATC

GAGGACGGCAGCGTGCAGCTCGCCGACCACTACCAGCAGAACACCCCCATCGGC

GACGGCCCCGTGCTGCTGCCCGACAACCACTACCTGAGCACCCAGTCCGCCCTGA

GCAAAGACCCCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCG

CCGCCGGGATCACTCTCGGCATGGACGAGCTGTACAAGGGATCCGGCGCAACAA

ACTTCTCTCTGCTGAAACAAGCCGGAGATGTCGAAGAGAATCCTGGACCGACCG

AGTACAAGCCCACGGTGCGCCTCGCCACCCGCGACGACGTCCCCAGGGCCGTAC

GCACCCTCGCCGCCGCGTTCGCCGACTACCCCGCCACGCGCCACACCGTCGATCC

GGACCGCCACATCGAGCGGGTCACCGAGCTGCAAGAACTCTTCCTCACGCGCGT

CGGGCTCGACATCGGCAAGGTGTGGGTCGCGGACGACGGCGCCGCGGTGGCGGT

CTGGACCACGCCGGAGAGCGTCGAAGCGGGGGCGGTGTTCGCCGAGATCGGCCC

GCGCATGGCCGAGTTGAGCGGTTCCCGGCTGGCCGCGCAGCAACAGATGGAAGG

CCTCCTGGCGCCGCACCGGCCCAAGGAGCCCGCGTGGTTCCTGGCCACCGTCGG

AGTCTCGCCCGACCACCAGGGCAAGGGTCTGGGCAGCGCCGTCGTGCTCCCCGG

AGTGGAGGCGGCCGAGCGCGCCGGGGTGCCCGCCTTCCTGGAGACCTCCGCGCC

CCGCAACCTCCCCTTCTACGAGCGGCTCGGCTTCACCGTCACCGCCGACGTCGAG

GTGCCCGAAGGACCGCGCACCTGGTGCATGACCCGCAAGCCCGGTGCCTGAACG

CGTTAAGTCGACAATCAACCTCTGGATTACAAAATTTGTGAAAGATTGACTGGTA

TTCTTAACTATGTTGCTCCTTTTACGCTATGTGGATACGCTGCTTTAATGCCTTTGT ATCATGCTATTGCTTCCCGTATGGCTTTCATTTTCTCCTCCTTGTATAAATCCTGGT

TGCTGTCTCTTTATGAGGAGTTGTGGCCCGTTGTCAGGCAACGTGGCGTGGTGTG

CACTGTGTTTGCTGACGCAACCCCCACTGGTTGGGGCATTGCCACCACCTGTCAG

CTCCTTTCCGGGACTTTCGCTTTCCCCCTCCCTATTGCCACGGCGGAACTCATCGC

CGCCTGCCTTGCCCGCTGCTGGACAGGGGCTCGGCTGTTGGGCACTGACAATTCC

GTGGTGTTGTCGGGGAAATCATCGTCCTTTCCTTGGCTGCTCGCCTGTGTTGCCAC

CTGGATTCTGCGCGGGACGTCCTTCTGCTACGTCCCTTCGGCCCTCAATCCAGCG

GACCTTCCTTCCCGCGGCCTGCTGCCGGCTCTGCGGCCTCTTCCGCGTCTTCGCCT

TCGCCCTCAGACGAGTCGGATCTCCCTTTGGGCCGCCTCCCCGCGTCGACTTTAA

GACCAATGACTTACAAGGCAGCTGTAGATCTTAGCCACTTTTTAAAAGAAAAGG

GGGGACTGGAAGGGCTAATTCACTCCCAACGAAGACAAGATCTGCTTTTTGCTTG

TACTGGGTCTCTCTGGTTAGACCAGATCTGAGCCTGGGAGCTCTCTGGCTAACTA

GGGAACCCACTGCTTAAGCCTCAATAAAGCTTGCCTTGAGTGCTTCAAGTAGTGT

GTGCCCGTCTGTTGTGTGACTCTGGTAACTAGAGATCCCTCAGACCCTTTTAGTC

AGTGTGGAAAATCTCTAGCAGGGCCCGTTTAAACCCGCTGATCAGCCTCGACTGT

GCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCC

TGGAAGGTGCCACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCA

TTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGTGGGGCAGGACAGCAA

GGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCTCTAT

GGCTTCTGAGGCGGAAAGAACCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCC

CTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGC

TACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCG

CCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTAGGGTT

CCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGT

TCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGT

CCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTAT

CTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTGGTTAA

AAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGT

CAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGC

ATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCA

GGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCC

CTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCA

TGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGC TATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCT

CCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAGCACGTGTTGACAATTAAT

CATCGGCATAGTATATCGGCATAGTATAATACGACAAGGTGAGGAACTAAACCA

TGGCCAAGTTGACCAGTGCCGTTCCGGTGCTCACCGCGCGCGACGTCGCCGGAG

CGGTCGAGTTCTGGACCGACCGGCTCGGGTTCTCCCGGGACTTCGTGGAGGACG

ACTTCGCCGGTGTGGTCCGGGACGACGTGACCCTGTTCATCAGCGCGGTCCAGGA

CCAGGTGGTGCCGGACAACACCCTGGCCTGGGTGTGGGTGCGCGGCCTGGACGA

GCTGTACGCCGAGTGGTCGGAGGTCGTGTCCACGAACTTCCGGGACGCCTCCGG

GCCGGCCATGACCGAGATCGGCGAGCAGCCGTGGGGGCGGGAGTTCGCCCTGCG

CGACCCGGCCGGCAACTGCGTGCACTTCGTGGCCGAGGAGCAGGACTGACACGT

GCTACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATC

GTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGT

TCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAA

TAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTT

TGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAG

AGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCAC

AATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTA

ATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCG

GGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGC

GGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGT

CGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCC

ACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAA

GGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCC

CCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACA

GGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTG

TTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTG

GCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTC

CAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCC

GGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAG

CAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGT

TCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTG

CGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGC

AAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGC GCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGC TCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAG GATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGT ATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTA

TCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAG ATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCG CGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGA

AGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTA ATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGT TGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCAT TCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAA AAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCA GTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATC CGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAG TGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGC CACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAA AACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGC

ACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAA ACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTG AATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTC TCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCC

GCGCACATTTCCCCGAAAAGTGCCACCTGACCACATTTCCCCGAAAAGTGCCACC TGACGTCGACGGATCGGGAGATCTCCCGATCCCCTATGGTGCACTCTCAGTACAA TCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAG GTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACC

GACAATTGCATGAAGAATCTGCTTAGGGTTAGGCGTTTTGCGCTGCTTCGCGATG TACGGGCCAGATATACGCGTT SEQ ID NO: 535

[00574] The following examples contemplate fusion proteins that have been cloned into a plasmid with the structure: [front half]-[insert]-[back half] . In other words, the plasmid has been split into a [front half] sequence and a [back half] sequence, which are joined by an [insert] sequence. The [front half] and [back half] sequences are the same but the [insert] sequence changes.

[00575] The [Front half] sequence comprises the following sequence:

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACT SEQ ID NO: 536

[00576] The [Back half] sequence comprises the following sequence:

TAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGAT

ACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAA

AAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTG

CAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAA

TACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCC

TTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGT

TGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAA

AACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGC

TGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCC

TGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTA

TATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTT

ACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTC

TCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGT

TTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAG

CATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGC

GTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAA

TGAATCGGCCAACGCGCGGGGA-3’ SEQ ID NO: 537 [00577] Contemplated [insert] sequences include, but are not limited to, the following:

[00578] Construct pCMV-COCAL [Cocal Fusogen]

ATGAACTTCCTGCTGCTGACATTCATCGTTCTGCCTCTGTGCAGCCACGCCAAGTT

CAGCATCGTGTTTCCACAGAGCCAGAAGGGCAACTGGAAGAACGTGCCCAGCAG

CTACCACTACTGTCCTTCTAGCTCCGACCAGAATTGGCACAATGATCTGTTGGGC

ATCACCATGAAAGTAAAGATGCCTAAGACCCATAAGGCCATCCAGGCCGACGGC

TGGATGTGCCACGCCGCTAAATGGATCACGACCTGCGACTTCAGATGGTACGGC

CCCAAATACATCACCCACAGCATCCACTCTATCCAACCTACAAGCGAGCAGTGTA

AAGAATCTATCAAGCAGACCAAGCAGGGAACCTGGATGAGCCCCGGCTTCCCCC

CCCAGAACTGCGGATATGCCACCGTGACAGACAGCGTGGCTGTGGTGGTGCAGG

CCACCCCTCATCACGTGCTGGTGGACGAGTACACCGGCGAGTGGATCGACAGCC

AGTTCCCTAACGGCAAGTGCGAGACAGAAGAGTGCGAAACCGTGCACAACAGCA

CAGTGTGGTATAGCGACTACAAGGTTACAGGACTGTGTGATGCCACCCTGGTCG

ATACCGAGATCACCTTCTTCTCCGAAGATGGCAAAAAGGAAAGCATCGGCAAAC

CTAATACCGGCTACCGGTCCAACTACTTCGCCTACGAGAAGGGCGATAAGGTGT

GCAAGATGAACTACTGCAAGCACGCCGGCGTCCGGCTGCCTAGCGGCGTGTGGT

TCGAGTTCGTGGATCAGGACGTGTACGCCGCAGCTAAGCTGCCTGAATGTCCTGT

TGGCGCTACAATCAGCGCCCCTACACAGACCTCTGTGGACGTGTCCCTTATCCTG

GATGTGGAACGCATTCTGGACTACAGCCTGTGCCAGGAGACATGGTCCAAGATC

CGGAGCAAGCAGCCTGTGTCTCCTGTGGACCTGAGCTACCTGGCCCCAAAGAAT

CCCGGCACCGGCCCTGCCTTCACCATCATCAACGGCACCCTGAAGTACTTCGAGA

CAAGATATATCAGAATTGACATCGACAACCCTATCATCAGCAAGATGGTGGGCA

AGATCTCCGGATCTCAAACTGAGAGAGAGCTGTGGACCGAGTGGTTTCCTTACG

AGGGCGTGGAAATCGGACCTAACGGGATCCTCAAGACCCCTACCGGCTACAAAT

TCCCCCTGTTTATGATCGGTCACGGCATGCTGGACTCTGATCTGCACAAGACCAG

CCAGGCTGAAGTGTTCGAGCACCCCCACCTGGCCGAGGCCCCAAAGCAACTGCC

AGAGGAAGAAACCCTGTTCTTCGGCGACACCGGAATTTCTAAAAACCCCGTGGA

ACTGATCGAGGGCTGGTTCAGCAGCTGGAAAAGCACCGTGGTCACATTCTTTTTT

GCCATCGGCGTGTTCATCCTGCTGTACGTGGTGGCCAGAATCGTGATCGCCGTGC GGTACAGATACCAGGGCAGCAACAACAAGAGAATCTACAACGACATCGAGATG

AGCAGATTCCGGAAG SEQ ID NO: 538

[00579] Construct pCMV-COCALmut [Cocalmut Fusogen]

ATGAACTTCCTGCTGCTGACATTCATCGTTCTGCCTCTGTGCAGCCACGCCAAGTT

CAGCATCGTGTTTCCACAGAGCCAGAAGGGCAACTGGAAGAACGTGCCCAGCAG

CTACCACTACTGTCCTTCTAGCTCCGACCAGAATTGGCACAATGATCTGTTGGGC

ATCACCATGAAAGTAAAGATGCCTCAGACCCATAAGGCCATCCAGGCCGACGGC

TGGATGTGCCACGCCGCTAAATGGATCACGACCTGCGACTTCAGATGGTACGGC

CCCAAATACATCACCCACAGCATCCACTCTATCCAACCTACAAGCGAGCAGTGTA

AAGAATCTATCAAGCAGACCAAGCAGGGAACCTGGATGAGCCCCGGCTTCCCCC

CCCAGAACTGCGGATATGCCACCGTGACAGACAGCGTGGCTGTGGTGGTGCAGG

CCACCCCTCATCACGTGCTGGTGGACGAGTACACCGGCGAGTGGATCGACAGCC

AGTTCCCTAACGGCAAGTGCGAGACAGAAGAGTGCGAAACCGTGCACAACAGCA

CAGTGTGGTATAGCGACTACAAGGTTACAGGACTGTGTGATGCCACCCTGGTCG

ATACCGAGATCACCTTCTTCTCCGAAGATGGCAAAAAGGAAAGCATCGGCAAAC

CTAATACCGGCTACCGGTCCAACTACTTCGCCTACGAGAAGGGCGATAAGGTGT

GCAAGATGAACTACTGCAAGCACGCCGGCGTCCGGCTGCCTAGCGGCGTGTGGT

TCGAGTTCGTGGATCAGGACGTGTACGCCGCAGCTAAGCTGCCTGAATGTCCTGT

TGGCGCTACAATCAGCGCCCCTACACAGACCTCTGTGGACGTGTCCCTTATCCTG

GATGTGGAACGCATTCTGGACTACAGCCTGTGCCAGGAGACATGGTCCAAGATC

CGGAGCAAGCAGCCTGTGTCTCCTGTGGACCTGAGCTACCTGGCCCCAAAGAAT

CCCGGCACCGGCCCTGCCTTCACCATCATCAACGGCACCCTGAAGTACTTCGAGA

CAAGATATATCAGAATTGACATCGACAACCCTATCATCAGCAAGATGGTGGGCA

AGATCTCCGGATCTCAAACTGAGGCCGAGCTGTGGACCGAGTGGTTTCCTTACGA

GGGCGTGGAAATCGGACCTAACGGGATCCTCAAGACCCCTACCGGCTACAAATT

CCCCCTGTTTATGATCGGTCACGGCATGCTGGACTCTGATCTGCACAAGACCAGC

CAGGCTGAAGTGTTCGAGCACCCCCACCTGGCCGAGGCCCCAAAGCAACTGCCA

GAGGAAGAAACCCTGTTCTTCGGCGACACCGGAATTTCTAAAAACCCCGTGGAA CTGATCGAGGGCTGGTTCAGCAGCTGGAAAAGCACCGTGGTCACATTCTTTTTTG

CCATCGGCGTGTTCATCCTGCTGTACGTGGTGGCCAGAATCGTGATCGCCGTGCG

GTACAGATACCAGGGCAGCAACAACAAGAGAATCTACAACGACATCGAGATGA

GCAGATTCCGGAAG SEQ ID NO: 539

[00580] Construct pCMV-Nipah-Gmut [Nipah-Gmut Fusogen]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACC SEQ ID NO: 540

[00581] Construct pCMV-Nipah-Gmuttrunc [Nipah-Gmut trunc Fusogen]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACC SEQ ID NO: 541

[00582] Construct pCMV-VSV-G [VSV-G Fusogen]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCAC

CATAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTAC

CATTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAG

CCTTACAAGTCAAAATGCCCAAGAGTCACAAGGCTATTCAAGCAGACGGTTGGA

TGTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAA

GTATATAACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAA

AGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAA

AGTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACT

CCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCA

TCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTG

GCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGAC ATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACA

GGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATG

CAATACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATG

GCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAA

GTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGA

GAGGATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGG

TCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACC

GGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACA

TCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGG

AACTACCACAGAAAGGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGA

AATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATAC

ATGATTGGACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGG

TGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAG

TTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGT

TGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAAT

CATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGC

ACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG

SEQ ID NO: 542

[00583] Construct pCMV- VS VGmut [VSV-Gmut Fusogen]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCAC

CATAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTAC

CATTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAG

CCTTACAAGTCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGA

TGTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAA

GTATATAACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAA

AGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAA

AGTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACT

CCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCA TCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTG

GCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGAC

ATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACA

GGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATG

CAATACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATG

GCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAA

GTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGA

GAGGATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGG

TCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACC

GGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACA

TCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGG

AACTACCACAGAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGA

AATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATAC

ATGATTGGACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGG

TGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAG

TTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGT

TGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAAT

CATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGC

ACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG

SEQ ID NO: 543

[00584] Construct VSV-Gmut2 [VSV-Gmut2 Fusogen]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCAC

CATAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTAC

CATTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAG

CCTTACAAGTCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGA

TGTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAA

GTATATAACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAA

AGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAA AGTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACT

CCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCA

TCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTG

GCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGAC

ATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACA

GGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATG

CAATACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATG

GCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAA

GTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGA

GAGGATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGG

TCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACC

GGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACA

TCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGG

AACTACCACAGAACAGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGA

AATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATAC

ATGATTGGACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGG

TGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAG

TTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGT

TGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAAT

CATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGC

ACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGT

AA SEQ ID NO: 544

[00585] Construct pJAQ 106 [CXCL12 Targeting Domain]-[SGGSx3.1 Linker]- [VSV-G mut TM]

ATGAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCA

GCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGAAA GCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCAAACTG

TGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGCATTGA

CCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAGAGCGG

TGGGAGCGGCGGGAGCGGCGGTAGCATGAAGTGCCTTTTGTACTTAGCCTTTTTA

TTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGAA

ACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAAA

TTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGTCA

CAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTACT

TGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTCA

CTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACTT

GGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATGC

CGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACACA

GGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATGC

CCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTAT

GTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCT

ATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATGA

AACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGACT

CCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGA

TTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGG

ATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGA

AACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTAT

CTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACCC

TAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCTC

AAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGATGA

CTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAG

TTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGATC

TTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGC

TTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAA

ATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTC

_{TTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTAT}

CCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACAT

AGAGATGAACCGACTTGGAAAG SEQ ID NO: 545 [00586] Construct pJAQl 13 [AdF35 Genscript Codon Optimized Targeting

Domain]-[SGGSx3.1 Linker] -[ VS V-G TM]

ATGACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTACGAGG

ACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCTAATGG

CTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTCTCACC

ACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGGACGAC

ACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCAAGAAC

AACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAACAACAA

GCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATCTGTAT

CAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATTGCCAG

ATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGGTTAAG

AACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATACAGTG

AACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTCGACT

CCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAAAACA

AGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATGCCTA

GCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTACATCC

ACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGAACAT

TAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCATCCA

GTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCACACT

GACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACAGCGGTGGG

AGCGGCGGGAGCGGCGGTAGCAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTG

GGGTGAATTGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGAAACTGGA

AAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAAATTGGCAT

AATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCAAGAGTCACAAGGCT

ATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTGTGATT

TCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTCACTCCATC TGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACTTGGCTGA

ATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCGAAGC

AGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAA

TGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTG

TCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTC

TAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCC

CTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGA

GGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCCCATCA

GGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTG

AATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAG

TCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAACCTGG

AGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTC

CTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATA

CTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATG

GTCGGAATGATCAGTGGAACTACCACAGAAAGGGAACTGTGGGATGACTGGGCA

CCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGA

TATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGATCTTCATCT

TAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAA

CTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAAT

CGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCT

TTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTT

TGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATG

AACCGACTTGGAAAG SEQ ID NO: 546

[00587] Construct pJAQl 14 [TPO Genscript Optimized Targeting Domain]- [SGGSx3.1 Linker]-[VSV-G TM]

ATGGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGA

CCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCT

GAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCT

CTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGA

CCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGC

TTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCT

GCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCT

GCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAA

CGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTCTGATG

CTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGCCGTGC

CCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACGAGCG

GCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGTCTGCT

GAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAGACATC

TAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGCTGAA

CGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTCCTGAT

ATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAACCTGGA

TATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCCTCTGC

CTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGACCCTAG

CGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACACACAGC

CAGAACCTGTCTCAGGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCAT

GAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCA

TAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCA

TTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCC

TTACAAGTCAAAATGCCCAAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATG

TGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGT

ATATAACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAG

CATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAG

TTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCT

CACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCA

ACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCA

TTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATC

ACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGG

TTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAA TACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTG

ATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTAT

CTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGG

ATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTC

CAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCC

TGCTTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGA

GTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTA

CCACAGAAAGGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTG

GACCCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGAT

TGGACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTC

GAACATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTAT

TTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTT

CAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTG

GACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACC

AAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTC

AAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATG

CTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAAAAAAAA

AAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCAGGTGCAGGCT

GCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCACAAATACCACT

GAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCA

TCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATT

TTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCA

GAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATG

AACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTC

CATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTG

TTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGC

CAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATG

GAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATAGCTGTTTCCTGT

GTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAA

GTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGC

TCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCG

GCCAACGCGCGGGGA SEQ ID NO: 547 [00588] Construct pJAQl 15 [SCF full Targeting Domain]-[SGGSx3.2 Linker]- [VSV-G TM]

ATGAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGT

TTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACG

TGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCC

TGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGA

TGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACAT

TTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGA

CGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTT

CAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAAC

CGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCG

TGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGC

CATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTC

TAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTAT

GGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATT

GGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAAC

GAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGA

GGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATGAAGTGCCTTTTGTACTT

AGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCCACACAACC

AAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTC

AGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCC

AAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGG

GTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCC

GATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAAC

AAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGT

GACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGAT

GAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAAT TACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCA

AAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGA

CGGAGAGCTATCATCCCCGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTT

TGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGG

AGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCT

GCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGA

CCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCT

CTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGA

TCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATC

AATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTC

CAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAAGGGAAC

TGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTC

TGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTT

GGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATT

CAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTG

GGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAA

GCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTC

TCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGAT

TTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 548

Construct pJAQl 17 [SCF full Targeting Domain]

ATGAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGT

TTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACG

TGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCC

TGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGA

TGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACAT

TTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGA

CGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTT

CAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAAC CGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCG

TGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGC

CATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTC

TAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTAT

GGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATT

GGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAAC

GAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGA

GGTG SEQ ID NO: 549

[00589] Construct pJAQ129 [CD8a Signal Peptide]-[SCF mutant (V49L/F63L)

Targeting Domain] -[SGGSx3.2 Einker] -[ VS V-G mut TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGCTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGCTGAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATGAAGTGCCTTTTGT

ACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCCACAC

AACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAA

GCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAAT

GCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAA

ATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCC

ATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACG

AAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAA

CTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGT

TGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAG

CAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAG

GTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAG

AGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACT

ACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATT

GGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTT

TGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCT

CAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATT

CCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGT

GGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATA

ATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTG

CTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGG

AACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAG

TTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTAT

GTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCAC

ATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATAC

TGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAA

AGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTT

CTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAG

ATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 550 [00590] Construct pJAQ 130 [CD8a Signal Peptide]-[SCF mutant

(V49L/F63L/K91E) Targeting Domain]-[SGGSx3.2 Linker] -[ VS V-G mut TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGCTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGCTGAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGGAGGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATGAAGTGCCTTTTGT

ACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCCACAC

AACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAA

GCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAAT

GCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAA

ATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCC

ATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACG

AAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAA CTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGT

TGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAG

CAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAG

GTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAG

AGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACT

ACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATT

GGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTT

TGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCT

CAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATT

CCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGT

GGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATA

ATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTG

CTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGG

AACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAG

TTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTAT

GTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCAC

ATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATAC

TGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAA

AGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTT

CTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAG

ATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 551

[00591] Construct pJAQ131 [CD8a Signal Peptide]-[SCF mutant

(V49L/F63L/K91E/I98R) Targeting Domain]-[SGGSx3.2 Einker] -[ VS V-G mut TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGCTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGCTGAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGGAGGAGAACAGCTCCAAGGACCGGAAAAA

GTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATC

TTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTG

ATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGA

CCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAG

CAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGC

CGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTC

TGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGA

TTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATGAAGTGCCTTTTGT

ACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCCACAC

AACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAA

GCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAAT

GCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAA

ATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCC

ATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACG

AAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAA

CTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGT

TGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAG

CAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAG

GTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAG

AGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACT

ACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATT

GGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTT

TGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCT

CAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATT CCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGT

GGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATA

ATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTG

CTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGG

AACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAG

TTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTAT

GTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCAC

ATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATAC

TGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAA

AGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTT

CTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAG

ATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 552

[00592] Construct pJAQ 132 [SCF soluble Targeting Domain]-[SGGSx3.2 Linker]- [VSV-G mut TM]

ATGGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAA

GCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGC

ATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGC

GATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCA

ATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGT

GAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAG

ACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTT

AAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGT

CCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGT

GGCCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATGAAGTGCCTTTTGTA

CTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCCACACA

ACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAG CTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATG

CCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAAT

GGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCAT

CCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAA

ACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACT

GTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTG

ATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCA

ATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGT

CAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAG

GACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTAC

TTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGG

GGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTG

CTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCA

GACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCC

CTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTG

GATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAA

TCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGC

TCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGA

ACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGT

TCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATG

TTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACA

TTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACT

GGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAA

AGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTT

CTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAG

ATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 553

[00593] Construct pJAQ 133 [CD8a Signal Peptide]-[SCF soluble Targeting

Domain]-[SGGSx3.2 Linker] -[ VS V-G mut TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGA

CAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGC

CTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGC

TGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCT

GAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGA

GTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGA

GCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGAC

GCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCA

CCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCC

TCCTGTGGCCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATGAAGTGCCT

TTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTC

CACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCC

GTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTC

AAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCT

TCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACAC

ATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACA

AACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATAT

GCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGC

TGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAAT

GCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTA

TAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCT

CAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGT

AACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAG

CATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATC

TCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCC

ATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGAT

TATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTC

CAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCAC

CATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATT GCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAA

GCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAAT

GGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATG

GTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCC

TCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTG

ATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTG

GAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCT

TGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAG

ACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 554

[00594] Construct pJAQ134 [SCF full Targeting Domain]-[SGGSx3.2 Linker]- [CD43 TM]

ATGAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGT

TTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACG

TGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCC

TGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGA

TGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACAT

TTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGA

CGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTT

CAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAAC

CGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCG

TGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGC

CATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTC

TAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTAT

GGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATT

GGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAAC

GAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGA GGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCGGCATGCTGCCTGTGGCTGT

GCTGGTGGCCCTGCTCGCCGTGATCGTGCTGGTCGCCCTGCTGCTGCTGTGGCGG

AGAAGACAGAAGAGACGGACCSEQ ID NO: 555

[00595] Construct pJAQ136 [SCF full Targeting Domain]-[SGGSx3.2 Linker]- [CD49d TM]

ATGAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGT

TTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACG

TGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCC

TGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGA

TGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACAT

TTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGA

CGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTT

CAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAAC

CGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCG

TGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGC

CATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTC

TAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTAT

GGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATT

GGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAAC

GAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGA

GGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATCGTGATCATCTCTAGCAG

CCTGCTGCTGGGCCTGATCGTGCTGCTGCTGATCAGCTACGTGATGTGGAAGGCC

GGCTTCTTCAAAAGACAGTACAAGTCC SEQ ID NO: 556 [00596] Construct pJAQ138 [SCF full Targeting Domain]-[SGGSx3.2 Linker]- [CD62L TM]

ATGAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGT

TTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACG

TGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCC

TGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGA

TGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACAT

TTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGA

CGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTT

CAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAAC

CGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCG

TGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGC

CATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTC

TAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTAT

GGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATT

GGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAAC

GAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGA

GGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCCCTCTGTTCATCCCCGTGGC

CGTGATGGTGACCGCCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGAAGA

CTGAAGAAGGGCAAGAAATCTAAGCGG SEQ ID NO: 557

[00597] Construct pJAQ140 [SCF full Targeting Domain]-[SGGSx3.2 Linker]- [CD162 TM]

ATGAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGT

TTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACG

TGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCC

TGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGA

TGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACAT

TTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGA

CGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTT

CAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAAC

CGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCG

TGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGC

CATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTC

TAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTAT

GGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATT

GGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAAC

GAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGA

GGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCCTGCTGGCTATCCTGATCCT

GGCCCTGGTCGCCACAATCTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAGACTG

AGCAGAAAGGGCCACATGTACCCTGTGCGGAAC SEQ ID NO: 558

[00598] Construct pJAQ142 [SCF full Targeting Domain]-[SGGSx3.2 Linker]- [HLA-A2 TM]

ATGAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGT

TTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACG

TGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCC

TGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGA

TGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACAT

TTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGA

CGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTT

CAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAAC

CGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCG

TGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGC

CATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTC

TAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTAT

GGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATT

GGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAAC

GAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGA

GGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATCGTGGGCATCATCGCCG

GACTGGTGCTGTTCGGCGCCGTCATCACCGGCGCTGTGGTGGCCGCCGTGATGTG

GCGGAGAAAGTCTAGCGACAGAAAGGGC SEQ ID NO: 559

[00599] Construct pJAQ 144 [SCF full Targeting Domain]-[SGGSx3.2 Linker]-

[HLA-DRA TM]

ATGAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGT

TTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACG

TGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCC

TGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGA

TGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACAT

TTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGA

CGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTT

CAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAAC

CGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCG

TGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGC

CATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTC

TAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTAT

GGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATT

GGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAAC

GAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGA

GGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCAACGTGGTGTGCGCCCTGG

GCCTGACCGTGGGCCTGGTCGGCATCATCATTGGAACAATCTTCATCATCAAGGG

CCTGAGAAAGAGCAACGCCGCTGAGCGGAGAGGCCCTCTG SEQ ID NO: 560

[00600] Construct pJAQ146 [SCF full Targeting Domain]-[SGGSx3.2 Linker]- [ICAM1 TM]

ATGAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGT

TTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACG

TGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCC

TGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGA

TGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACAT

TTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGA

CGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTT

CAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAAC

CGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCG

TGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGC

CATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTC

TAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTAT

GGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATT

GGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAAC

GAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGA

GGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATCGTGATCATCACCGTGGT

CGCCGCCGCTGTGATCATGGGCACAGCCGGCCTGAGCACCTACCTGTACAACAG

ACAGAGAAAGATCAAGAAATACCGGCTG SEQ ID NO: 561

[00601] Construct pJAQ148 [SCF full Targeting Domain]-[SGGSx3.2 Linker]-

[LFA-1 TM]

ATGAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGT

TTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACG

TGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCC

TGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGA

TGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACAT

TTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGA

CGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTT

CAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAAC

CGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCG

TGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGC

CATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTC

TAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTAT

GGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATT

GGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAAC

GAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGA

GGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCTACCTGTACGTGCTGAGCGG

CATCGGCGGACTGCTGCTGCTGCTCCTGATCTTCATCGTGCTGTACAAGGTGGGC

TTTTTCAAAAGAAACCTGAAG SEQ ID NO: 562

[00602] Construct pJAQ153 [SCF full Targeting Domain]-[SGGSx3.2 Linker]-

[VSV-G mut TM]

ATGAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGT

TTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACG

TGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCC

TGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGA

TGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACAT

TTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGA

CGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTT

CAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAAC

CGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCG

TGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGC

CATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTC

TAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTAT

GGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATT

GGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAAC

GAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGA

GGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATGAAGTGCCTTTTGTACTT

AGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCCACACAACC

AAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTC

AGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCC

CAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGG

GTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCC

GATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAAC

AAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGT

GACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGAT

GAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAAT

TACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCA

AAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGA

CGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTT

TGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGG

AGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCT

GCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGA

CCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCT CTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGA

TCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATC

AATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTC

CAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAAC

TGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTC

TGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTT

GGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATT

CAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTG

GGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAA

GCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTC

TCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGAT

TTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 563

[00603] Construct pJAQ154 [CXCL12 Targeting Domain]-[SGGSx2.2 Linker]- [VSVG TM tail TM]

ATGAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCA

GCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGAAA

GCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCAAACTG

TGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGCATTGA

CCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAGAGCGG

TGGGAGCGGTGGGAGCATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGAC

TATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAG

AAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID

NO: 564 [00604] Construct pJAQ155 [AdF35 Genscript Codon Optimized Targeting

Domain]-[SGGSx2.2 Linker]-[VSVG TM tail TM]

ATGACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTACGAGG

ACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCTAATGG

CTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTCTCACC

ACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGGACGAC

ACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCAAGAAC

AACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAACAACAA

GCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATCTGTAT

CAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATTGCCAG

ATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGGTTAAG

AACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATACAGTG

AACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTCGACT

CCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAAAACA

AGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATGCCTA

GCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTACATCC

ACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGAACAT

TAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCATCCA

GTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCACACT

GACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACAGCGGTGGG

AGCGGTGGGAGCATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATT

CTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAA

AGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 565

[00605] Construct pJAQ156 [TPO Genscript Optimized Targeting Domain]-

[SGGSx2.2 Linker]-[VSVG TM tail TM]

ATGGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGA

CCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCT

GAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCT

CTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGA

CCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGC

TTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCT

GCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCT

GCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAA

CGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTCTGATG

CTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGCCGTGC

CCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACGAGCG

GCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGTCTGCT

GAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAGACATC

TAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGCTGAA

CGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTCCTGAT

ATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAACCTGGA

TATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCCTCTGC

CTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGACCCTAG

CGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACACACAGC

CAGAACCTGTCTCAGGAGGGCAGCGGTGGGAGCGGTGGGAGCATTGCCTCTTTT

TTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCA

TCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGA

GATGAACCGACTTGGAAAG SEQ ID NO: 566

[00606] Construct pJAQ157 [SCF full Targeting Domain]-[SGGSx3.2 Linker]- [VSVG TM tail TM]

ATGAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGT

TTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACG

TGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCC

TGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGA

TGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACAT

TTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGA

CGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTT

CAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAAC

CGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCG

TGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGC

CATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTC

TAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTAT

GGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATT

GGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAAC

GAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGA

GGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATTGCCTCTTTTTTCTTTATC

ATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCAT

TAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCG

ACTTGGAAAG SEQ ID NO: 567

[00607] Construct pJAQ158 [VSV-G Signal Peptide]-[SCF full Targeting Domain]-

[SGGSx3.2 Linker]-[VSVG TM tail TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAAAAAA

CCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTG

GTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGT

GACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGT

GCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCA

GCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGC

CTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTT

GAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCC

GAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCG

ACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAG

CACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTG

CCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAG

GCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCT

GCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAA

GACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATA

ACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGT

GGGAGCGGCGGGAGCGGTGGGAGCATTGCCTCTTTTTTCTTTATCATAGGGTTAA

TCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAG

CACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG

SEQ ID NO: 568

[00608] Construct pJAQ 159 [CD8a Signal Peptide]-[SCF soluble mutant

(V49L/F63L/K91E) Targeting Domain]-[SGGSx3.2 Einker] -[ VS V-G mut TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGA

CAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGC

CTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCT

GAGCGATTCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTG

AGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAG

TGCGTGGAGGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAG

CCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACG

CCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCAC

CCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCT

CCTGTGGCCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATGAAGTGCCTT

TTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCC

ACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCG

TCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCA

AAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTC

CAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACAT

TCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAA

CGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGC

AACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTG

GTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGC

AGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATA

AGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTC

AGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTA

ACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGC

ATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCT

CTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCA

TCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATT

ATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCC

AGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACC

ATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTG

CTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAG

CGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATG

GAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGG TATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCT

CACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGA

TACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGG

AAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTT

GGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGA

CAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGSEQ ID NO: 569

[00609] Construct pJAQ160 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker]-[CD43 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCC

CCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGC

CCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTG

CGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCT

CTGGTGATCACCCTGTACTGCAGCGGTGGGAGCGGCATGCTGCCTGTGGCTGTGC

TGGTGGCCCTGCTCGCCGTGATCGTGCTGGTCGCCCTGCTGCTGCTGTGGCGGAG

AAGACAGAAGAGACGGACC SEQ ID NO: 570

[00610] Construct pJAQ161 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker]-[CD49d.2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCC

CCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGC

CCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTG

CGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCT

CTGGTGATCACCCTGTACTGCAGCGGTGGGAGCATCGTGATCATCTCTAGCAGCC

TGCTGCTGGGCCTGATCGTGCTGCTGCTGATCAGCTACGTGATGTGGAAGGCCGG

CCTCTTCAAAAAACAGTACAAGTCC SEQ ID NO: 571

[00611] Construct pJAQ162 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker] -[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCC

CCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGC

CCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTG

CGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCT

CTGGTGATCACCCTGTACTGCAGCGGTGGGAGCCCTCTGTTCATCCCCGTGGCCG

TGATGGTGACCGCCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGAAGACT

GAAGAAGGGCAAGAAATCTAAGCGG SEQ ID NO: 572

[00612] Construct pJAQ163 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker] - [CD 162 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCC

CCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGC

CCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTG

CGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCT

CTGGTGATCACCCTGTACTGCAGCGGTGGGAGCCTGCTGGCTATCCTGATCCTGG

CCCTGGTCGCCACAATCTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAGACTGAG

CAGAAAGGGCCACATGTACCCTGTGCGGAAC SEQ ID NO: 573

[00613] Construct pJAQ164 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker] - [HLA-A2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCC

CCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGC

CCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTG

CGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCT

CTGGTGATCACCCTGTACTGCAGCGGTGGGAGCATCGTGGGCATCATCGCCGGA

CTGGTGCTGTTCGGCGCCGTCATCACCGGCGCTGTGGTGGCCGCCGTGATGTGGC

GGAGAAAGTCTAGCGACAGAAAGGGC SEQ ID NO: 574

[00614] Construct pJAQ165 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker] -[HLA-DRA TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCC

CCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGC

CCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTG

CGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCT

CTGGTGATCACCCTGTACTGCAGCGGTGGGAGCAACGTGGTGTGCGCCCTGGGC

CTGACCGTGAGCCTGGTCGGCATCATCATTGGAACAATCTTCATCATCAAGGGCC

TGAGAAAGAGCAACGCCGCTGAGCGGAGAGGCCCTCTG SEQ ID NO: 575

[00615] Construct pJAQ166 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCC

CCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGC

CCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTG

CGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCT

CTGGTGATCACCCTGTACTGCAGCGGTGGGAGCATCGTGATCATCACCGTGGTCG

CCGCCGCTGTGATCATGGGCACAGCCGGCCTGAGCACCTACCTGTACAACAGAC

AGAGAAAGATCAAGAAATACCGGCTG SEQ ID NO: 576

[00616] Construct pJAQ167 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker] -[LF A- 1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCC

CCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGC

CCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTG

CGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCT

CTGGTGATCACCCTGTACTGCAGCGGTGGGAGCTACCTGTACGTGTTGAGCGGCA

TCGGCGGACTGCTGCTGCTGCTCCTGATCTTCATCGTGCTGTACAAGGTGGGCTT

TTTCAAAAGAAACCTGAAG

[00617] Construct pJAQ168 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx2.1 Linker]-[IgG4 Fc CH3 Hinge]-[SGGSxl Linker]-[CD43 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGTAGCCCCGGCCAACCTCGGGAACCCCAG

GTGTACACCCTGCCTCCTAGCCAGGAGGAAATGACCAAGAACCAGGTGTCCCTC

ACATGTCTGGTGAAGGGATTCTACCCCAGCGACATCGCCGTGGAATGGGAGAGC

AACGGCCAGCCTGAGAACAACTACAAGACCACCCCTCCAGTGCTGGACAGCGAT

GGCAGCTTCTTTCTGTATAGCAGACTGACCGTGGACAAGTCCAGATGGCAGGAG

GGCAATGTGTTCAGCTGCAGCGTGATGCACGAGGCTCTGCACAACCACTACACA

CAGAAATCTCTGAGCCTGTCTCTGGGCAAGAGCGGTGGGAGCGGCATGCTGCCT

GTGGCTGTGCTGGTGGCCCTGCTCGCCGTGATCGTGCTGGTCGCCCTGCTGCTGC

TGTGGCGGAGAAGACAGAAGAGACGGACC SEQ ID NO: 577

[00618] Construct pJAQ169 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx2.1 Linker]-[IgG4 Fc CH3 Hinge]-[SGGSxl Einker] -[CD49d TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGTAGCCCCGGCCAACCTCGGGAACCCCAG

GTGTACACCCTGCCTCCTAGCCAGGAGGAAATGACCAAGAACCAGGTGTCCCTC

ACATGTCTGGTGAAGGGATTCTACCCCAGCGACATCGCCGTGGAATGGGAGAGC

AACGGCCAGCCTGAGAACAACTACAAGACCACCCCTCCAGTGCTGGACAGCGAT

GGCAGCTTCTTTCTGTATAGCAGACTGACCGTGGACAAGTCCAGATGGCAGGAG

GGCAATGTGTTCAGCTGCAGCGTGATGCACGAGGCTCTGCACAACCACTACACA

CAGAAATCTCTGAGCCTGTCTCTGGGCAAGAGCGGTGGGAGCATCGTGATCATCT

CTAGCAGCCTGCTGCTGGGCCTGATCGTGCTGCTGCTGATCAGCTACGTGATGTG

GAAGGCCGGCTTCTTCAAAAGACAGTACAAGTCC SEQ ID NO: 578 [00619] Construct pJAQ170 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx2.1 Linker]-[IgG4 Fc CH3 Hinge]-[SGGSxl Linker] -[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGTAGCCCCGGCCAACCTCGGGAACCCCAG

GTGTACACCCTGCCTCCTAGCCAGGAGGAAATGACCAAGAACCAGGTGTCCCTC

ACATGTCTGGTGAAGGGATTCTACCCCAGCGACATCGCCGTGGAATGGGAGAGC

AACGGCCAGCCTGAGAACAACTACAAGACCACCCCTCCAGTGCTGGACAGCGAT

GGCAGCTTCTTTCTGTATAGCAGACTGACCGTGGACAAGTCCAGATGGCAGGAG

GGCAATGTGTTCAGCTGCAGCGTGATGCACGAGGCTCTGCACAACCACTACACA

CAGAAATCTCTGAGCCTGTCTCTGGGCAAGAGCGGTGGGAGCCCTCTGTTCATCC CCGTGGCCGTGATGGTGACCGCCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGC

CAGAAGACTGAAGAAGGGCAAGAAATCTAAGCGGSEQ ID NO: 579

[00620] Construct pJAQ171 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx2.1 Linker]-[IgG4 Fc CH3 Hinge]-[SGGSxl Linker] -[CD 162 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGTAGCCCCGGCCAACCTCGGGAACCCCAG

GTGTACACCCTGCCTCCTAGCCAGGAGGAAATGACCAAGAACCAGGTGTCCCTC

ACATGTCTGGTGAAGGGATTCTACCCCAGCGACATCGCCGTGGAATGGGAGAGC AACGGCCAGCCTGAGAACAACTACAAGACCACCCCTCCAGTGCTGGACAGCGAT

GGCAGCTTCTTTCTGTATAGCAGACTGACCGTGGACAAGTCCAGATGGCAGGAG

GGCAATGTGTTCAGCTGCAGCGTGATGCACGAGGCTCTGCACAACCACTACACA

CAGAAATCTCTGAGCCTGTCTCTGGGCAAGAGCGGTGGGAGCCTGCTGGCTATCC

TGATCCTGGCCCTGGTCGCCACAATCTTCTTCGTGTGCACCGTGGTGCTGGCCGT

GAGACTGAGCAGAAAGGGCCACATGTACCCTGTGCGGAAC SEQ ID NO: 580

[00621] Construct pJAQ172 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx2.1 Linker]-[IgG4 Fc CH3 Hinge]-[SGGSxl Einker] -[HEA-A2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGTAGCCCCGGCCAACCTCGGGAACCCCAG

GTGTACACCCTGCCTCCTAGCCAGGAGGAAATGACCAAGAACCAGGTGTCCCTC

ACATGTCTGGTGAAGGGATTCTACCCCAGCGACATCGCCGTGGAATGGGAGAGC

AACGGCCAGCCTGAGAACAACTACAAGACCACCCCTCCAGTGCTGGACAGCGAT

GGCAGCTTCTTTCTGTATAGCAGACTGACCGTGGACAAGTCCAGATGGCAGGAG

GGCAATGTGTTCAGCTGCAGCGTGATGCACGAGGCTCTGCACAACCACTACACA

CAGAAATCTCTGAGCCTGTCTCTGGGCAAGAGCGGTGGGAGCATCGTGGGCATC

ATCGCCGGACTGGTGCTGTTCGGCGCCGTCATCACCGGCGCTGTGGTGGCCGCCG

TGATGTGGCGGAGAAAGTCTAGCGACAGAAAGGGC SEQ ID NO: 581

[00622] Construct pJAQ173 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx2.1 Linker]-[IgG4 Fc CH3 Hinge]-[SGGSxl Linker] -[HLA-DRA TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGTAGCCCCGGCCAACCTCGGGAACCCCAG

GTGTACACCCTGCCTCCTAGCCAGGAGGAAATGACCAAGAACCAGGTGTCCCTC

ACATGTCTGGTGAAGGGATTCTACCCCAGCGACATCGCCGTGGAATGGGAGAGC

AACGGCCAGCCTGAGAACAACTACAAGACCACCCCTCCAGTGCTGGACAGCGAT

GGCAGCTTCTTTCTGTATAGCAGACTGACCGTGGACAAGTCCAGATGGCAGGAG

GGCAATGTGTTCAGCTGCAGCGTGATGCACGAGGCTCTGCACAACCACTACACA

CAGAAATCTCTGAGCCTGTCTCTGGGCAAGAGCGGTGGGAGCAACGTGGTGTGC

GCCCTGGGCCTGACCGTGGGCCTGGTCGGCATCATCATTGGAACAATCTTCATCA

TCAAGGGCCTGAGAAAGAGCAACGCCGCTGAGCGGAGAGGCCCTCTG SEQ ID NO: 582

[00623] Construct pJAQ174 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx2.1 Linker]-[IgG4 Fc CH3 Hinge]-[SGGSxl Linker] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGTAGCCCCGGCCAACCTCGGGAACCCCAG

GTGTACACCCTGCCTCCTAGCCAGGAGGAAATGACCAAGAACCAGGTGTCCCTC

ACATGTCTGGTGAAGGGATTCTACCCCAGCGACATCGCCGTGGAATGGGAGAGC

AACGGCCAGCCTGAGAACAACTACAAGACCACCCCTCCAGTGCTGGACAGCGAT

GGCAGCTTCTTTCTGTATAGCAGACTGACCGTGGACAAGTCCAGATGGCAGGAG

GGCAATGTGTTCAGCTGCAGCGTGATGCACGAGGCTCTGCACAACCACTACACA

CAGAAATCTCTGAGCCTGTCTCTGGGCAAGAGCGGTGGGAGCATCGTGATCATC

ACCGTGGTCGCCGCCGCTGTGATCATGGGCACAGCCGGCCTGAGCACCTACCTGT

ACAACAGACAGAGAAAGATCAAGAAATACCGGCTG SEQ ID NO: 583

[00624] Construct pJAQ175 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx2.1 Linker]-[IgG4 Fc CH3 Hinge]-[SGGSxl Linker] -[LF A- 1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGTAGCCCCGGCCAACCTCGGGAACCCCAG

GTGTACACCCTGCCTCCTAGCCAGGAGGAAATGACCAAGAACCAGGTGTCCCTC

ACATGTCTGGTGAAGGGATTCTACCCCAGCGACATCGCCGTGGAATGGGAGAGC

AACGGCCAGCCTGAGAACAACTACAAGACCACCCCTCCAGTGCTGGACAGCGAT

GGCAGCTTCTTTCTGTATAGCAGACTGACCGTGGACAAGTCCAGATGGCAGGAG

GGCAATGTGTTCAGCTGCAGCGTGATGCACGAGGCTCTGCACAACCACTACACA

CAGAAATCTCTGAGCCTGTCTCTGGGCAAGAGCGGTGGGAGCTACCTGTACGTG

CTGAGCGGCATCGGCGGACTGCTGCTGCTGCTCCTGATCTTCATCGTGCTGTACA

AGGTGGGCTTTTTCAAAAGAAACCTGAAG SEQ ID NO: 584

[00625] Construct pJAQ176 [VSV-G Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.2 Linker]-[CD43 TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAAAAAA

CCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTG

GTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGT

GACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGT

GCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCA

GCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGC

CTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTT

GAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCC

GAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCG

ACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAG

CACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTG

CCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAG

GCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCT

GCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAA

GACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATA

ACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGT

GGGAGCGGCGGGAGCGGTGGGAGCGGCATGCTGCCTGTGGCTGTGCTGGTGGCC

CTGCTCGCCGTGATCGTGCTGGTCGCCCTGCTGCTGCTGTGGCGGAGAAGACAGA

AGAGACGGACC SEQ ID NO: 585

[00626] Construct pJAQ180 [VSV-G Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.2 Linker]- [CD 62L TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAAAAAA

CCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTG

GTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGT

GACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGT GCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCA

GCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGC

CTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTT

GAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCC

GAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCG

ACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAG

CACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTG

CCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAG

GCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCT

GCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAA

GACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATA

ACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGT

GGGAGCGGCGGGAGCGGTGGGAGCCCTCTGTTCATCCCCGTGGCCGTGATGGTG

ACCGCCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGAAGACTGAAGAAGG

GCAAGAAATCTAAGCGGSEQ ID NO: 586

[00627] Construct pJAQ182 [VSV-G Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.2 Linker] -[CD 162 TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAAAAAA

CCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTG

GTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGT

GACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGT

GCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCA

GCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGC

CTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTT

GAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCC GAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCG

ACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAG

CACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTG

CCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAG

GCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCT

GCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAA

GACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATA

ACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGT

GGGAGCGGCGGGAGCGGTGGGAGCCTGCTGGCTATCCTGATCCTGGCCCTGGTC

GCCACAATCTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAGACTGAGCAGAAAG

GGCCACATGTACCCTGTGCGGAAC SEQ ID NO: 587

[00628] Construct pJAQ183 [VSV-G Signal Peptide]-[SCF full Targeting Domain]- [SGGSxl Linker] -[CD 162 TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAAAAAA

CCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTG

GTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGT

GACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGT

GCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCA

GCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGC

CTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTT

GAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCC

GAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCG

ACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAG

CACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTG

CCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAG GCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCT

GCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAA

GACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATA

ACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGT

GGGAGCCTGCTGGCTATCCTGATCCTGGCCCTGGTCGCCACAATCTTCTTCGTGT

GCACCGTGGTGCTGGCCGTGAGACTGAGCAGAAAGGGCCACATGTACCCTGTGC

GGAAC SEQ ID NO: 588

[00629] Construct pJAQ 193 [VSV-G Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain]-[SGGSx2.2 Linker]-[VSVG TM tail TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCACCAAAAG

AGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTACGAGGACGAGAGCACC

TCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCTAATGGCTTTACCCAAA

GCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTCTCACCACCACAGGCG

GCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGGACGACACCGACGGCA

CACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCAAGAACAACCACAGCG

TGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAACAACAAGCTGTGCGCCA

AGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATCTGTATCAAGGACTCTA

TCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATTGCCAGATCGTGGAAA

ACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGGTTAAGAACGGAGGCC

TGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATACAGTGAACCAGATGTT

CACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTCGACTCCAGTGGCAAC

CTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAAAACAAGAGCAGCACC

GCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATGCCTAGCACCACAGCT

TATCCTTTTAACACCACCACACGGGACAGCGAGAACTACATCCACGGCATCTGCT ACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGAACATTAGCATCATGCT

GAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCATCCAGTTCGAGTGGAA

CCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCACACTGACCACATCTCCT

TTTTTCTTCAGCTACATCACCGAAGATGACAACAGCGGTGGGAGCGGTGGGAGC

ATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGA

GTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATA

CAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 589

[00630] Construct pJAQ195 [VSV-G Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.2 Linker]-[VSV-G Signal Peptide]-[VSV-G mut del SP TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAAAAAA

CCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTG

GTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGT

GACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGT

GCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCA

GCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGC

CTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTT

GAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCC

GAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCG

ACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAG

CACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTG

CCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAG

GCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCT

GCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAA

GACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATA ACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGT

GGGAGCGGCGGGAGCGGTGGGAGCATGAAGTGCCTTTTGTACTTAGCCTTTTTAT

TCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGAAA

CTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAAATT

GGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGTCACA

AGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTG

TGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTCACT

CCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACTTGG

CTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCG

AAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACACAGG

AGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATGCCC

CACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGT

GATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTAT

CATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAA

CTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCC

CATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATT

CCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGAT

GTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAA

CCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCT

TGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTA

AAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAA

GAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGATGACT

GGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTT

CAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGATCTT

CATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTT

CGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAA

TCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCT

TTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTAT

CCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACAT

AGAGATGAACCGACTTGGAAAG SEQ ID NO: 590 [00631] Construct pJAQ211 [CD8a Signal Peptide]-[SCF mutant (V49L/F63L)

Targeting Domain] -[SGGSx3.2 Linker] -[ VS V-G TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGCTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGCTGAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATGAAGTGCCTTTTGT

ACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCCACAC

AACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAA

GCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAAT

GCCCAAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAA

ATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCC

ATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACG

AAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAA CTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGT

TGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAG

CAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAG

GTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAG

AGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACT

ACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATT

GGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTT

TGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCT

CAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCCTGGATTATT

CCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGT

GGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATA

ATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTG

CTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAAGGG

AACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAG

TTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTAT

GTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCAC

ATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATAC

TGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAA

AGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTT

CTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAG

ATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 591

[00632] Construct pJAQ212 [CD8a Signal Peptide]-[SCF mutant (V49L/F63L/K91E) Targeting Domain]-[SGGSx3.2 Einker] -[ VS V-G TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGCTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGCTGAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGGAGGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATGAAGTGCCTTTTGT

ACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCCACAC

AACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAA

GCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAAT

GCCCAAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAA

ATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCC

ATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACG

AAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAA

CTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGT

TGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAG

CAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAG

GTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAG

AGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACT

ACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATT

GGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTT

TGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCT

CAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATTCTGGATTATT CCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGT

GGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATA

ATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTG

CTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAAGGG

AACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAG

TTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTAT

GTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCAC

ATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATAC

TGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAA

AGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTT

CTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAG

ATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 592

[00633] Construct pJAQ213 [SCF soluble Targeting Domain]-[SGGSx3.2 Linker]- [VSV-G TM]

ATGGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAA

GCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGC

ATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGC

GATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCA

ATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGT

GAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAG

ACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTT

AAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGT

CCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGT

GGCCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATGAAGTGCCTTTTGTA

CTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCCACACA

ACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAG CTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATG

CCCAAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAAT

GGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCAT

CCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAA

ACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACT

GTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTG

ATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCA

ATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGT

CAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAG

GACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTAC

TTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGG

GGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTG

CTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCA

GACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCCTGGATTATTCC

CTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTG

GATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAA

TCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGC

TCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAAGGGA

ACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGT

TCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATG

TTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACA

TTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACT

GGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAA

AGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTT

CTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAG

ATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 593

[00634] Construct pJAQ214 [VSV-G Signal Peptide]-[TPO Genscript Optimized

Targeting Domain] -[SGGSx2.2 Linker]-[VSVG TM tail TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGAACTTAC

AGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGACCCTGTCCAGC

CCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCTGAGAGATAGC

CACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCTCTGCCTACCC

CTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAGATGG

AAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTTGAGGGCG

TGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCTGCTCGGACA

GCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCTGCTGGGGAC

CCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAACGCCATTTT

CCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTCTGATGCTGGTGGGC

GGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGCCGTGCCCAGCCGGA

CATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACGAGCGGCCTGCTGGA

AACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGTCTGCTGAAATGGCA

GCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAGACATCTAGAAGCCT

TGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGCTGAACGGCACCAG

AGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTCCTGATATCAGCAGC

GGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAACCTGGATATAGCCCC

AGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCCTCTGCCTCCTACAC

TGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGACCCTAGCGCCCCTAC

CCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACACACAGCCAGAACCTG

TCTCAGGAGGGCAGCGGTGGGAGCGGTGGGAGCATTGCCTCTTTTTTCTTTATCA

TAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATT

AAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCG

ACTTGGAAAG SEQ ID NO: 594

[00635] Construct pJAQ215 [VSV-G Signal Peptide]-[SCF soluble Targeting

Domain]-[SGGSx3.2 Linker]-[VSVG TM tail TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGAGGGCAT

CTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAA

TCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTG

CCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACA

GATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCA

TCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACA

GCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCC

CTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGT

GGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAG

GATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCG

GTGGGAGCGGCGGGAGCGGTGGGAGCATTGCCTCTTTTTTCTTTATCATAGGGTT

AATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAA

AGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAA

AG SEQ ID NO: 595

[00636] Construct pJAQ216 [VSV-G Signal Peptide]-[SCF soluble mutant

(V49L/F63L) Targeting Domain]-[SGGSx3.2 Einker]-[VSVG TM tail TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGAGGGCAT

CTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAA TCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTG

CCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGCGATTCTCTGACAG

ATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCAT

CGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAG

CTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCT

GAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGG

TGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGA

TAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGT

GGGAGCGGCGGGAGCGGTGGGAGCATTGCCTCTTTTTTCTTTATCATAGGGTTAA

TCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAG

CACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG

SEQ ID NO: 596

[00637] Construct pJAQ217 [VSV-G Signal Peptide]-[SCF soluble mutant (V49L/F63L/K91E) Targeting Domain]-[SGGSx3.2 Linker]-[VSVG TM tail TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGAGGGCAT

CTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAA

TCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTG

CCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGCGATTCTCTGACAG

ATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCAT

CGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGGAGGAGAACAG

CTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCT

GAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGG

TGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGA

TAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGGT GGGAGCGGCGGGAGCGGTGGGAGCATTGCCTCTTTTTTCTTTATCATAGGGTTAA

TCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAG

CACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG

SEQ ID NO: 597

[00638] Construct pJAQ218 [VSV-G Signal Peptide]-[SCF soluble mutant (V49L/F63L/K91E/I98R) Targeting Domain]-[SGGSx3.2 Einker]-[VSVG TM tail TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGAGGGCAT

CTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAA

TCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTG

CCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGCGATTCTCTGACAG

ATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCAT

CGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGGAGGAGAACAG

CTCCAAGGACCGGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCC

TGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTG

GTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGG

ATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCGG

TGGGAGCGGCGGGAGCGGTGGGAGCATTGCCTCTTTTTTCTTTATCATAGGGTTA

ATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAA

GCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAA

G SEQ ID NO: 598

[00639] Construct pJAQ219 [CD8a Signal Peptide]-[SCF mutant (V49L/F63L)

Targeting Domain] -[SGGSx3.2 Linker] -[VSV-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGCTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGCTGAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTT

TTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTG

CCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAA

GTCAAAATGCCCAAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCAT

GCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAA

CACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGA

ACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGG

ATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCAT

GTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGA

AAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTG ACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTT

CTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAG

AAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTG

CAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAA

GGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCT

GCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCC

TGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAAT

CTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCT

TTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCG

ATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCAC

AGAAAGGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACC

CAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGA

CATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAAC

ATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTT

GGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTA

GTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTA

TTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGA

AAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID

NO: 599

[00640] Construct pJAQ220 [CD8a Signal Peptide]-[SCF mutant

(V49L/F63L/K91E) Targeting Domain]-[SGGSx3.2 Linker] -[ VS V-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGCTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGCTGAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGGAGGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTT

TTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTG

CCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAA

GTCAAAATGCCCAAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCAT

GCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAA

CACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGA

ACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGG

ATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCAT

GTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGA

AAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTG

ACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTT

CTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAG

AAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTG

CAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAA

GGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCT

GCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCC

TGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAAT

CTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCT

TTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCG

ATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCAC AGAAAGGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACC

CAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGA

CATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAAC

ATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTT

GGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTA

GTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTA

TTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGA

AAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID

NO: 600

[00641] Construct pJAQ221 [CD8a Signal Peptide]-[SCF mutant

(V49L/F63L/K91E/I98R) Targeting Domain]-[SGGSx3.2 Linker] -[ VS V-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGCTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGCTGAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGGAGGAGAACAGCTCCAAGGACCGGAAAAA

GTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATC

TTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTG

ATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGA

CCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAG

CAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGC CGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTC

TGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGA

TTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTT

TTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTG

CCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAA

GTCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCAT

GCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAA

CACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGA

ACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGG

ATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCAT

GTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGA

AAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTG

ACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTT

CTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAG

AAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTG

CAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAA

GGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCT

GCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCT

TGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAAT

CTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCT

TTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCG

ATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCAC

AGAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACC

CAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGA

CATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAAC

ATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTT

GGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTA

GTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTA

TTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGA

AAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAA SEQ ID NO: 601 [00642] Construct pJAQ222 [CXCL12 Targeting Domain]-[SGGSx3.2 Linker]- [VSV-G mut del SP TM]

ATGAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCA

GCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGAAA

GCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCAAACTG

TGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGCATTGA

CCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAGAGCGG

TGGGAGCGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTTTTCCACACAACCA

AAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCA

GATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCC

AGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGG

TCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCG

ATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACA

AGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTG

ACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATG

AATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATT

ACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAA

AGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGAC

GGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTT

GCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGA

GTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTG

CAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGAC

CTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTC

TGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGAT

CTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCA

ATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCC

AATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACT GTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCT

GAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTG

GACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTC

AAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGG

GCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAG

CTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCT

CCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATT

TATACAGACATAGAGATGAACCGACTTGGAAAGTAA SEQ ID NO: 602

[00643] Construct pJAQ223 [SCF soluble Targeting Domain]-[SGGSx3.2 Linker]-

[VSV-G mut del SP TM]

ATGGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAA

GCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGC

ATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGC

GATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCA

ATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGT

GAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAG

ACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTT

AAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGT

CCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGT

GGCCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTTT

TCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGC

CCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAG

TCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATG

CTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAAC

ACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAA

CAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGA TATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATG

TGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAA

AATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGA

CTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTC

TTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGA

AGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGC

AAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAG

GATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTG

CTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTT

GGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATC

TCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTT

TCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGA

TATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACA

GAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCC

AATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGAC

ATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACA

TCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTG

GTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAG

TTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTAT

TCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAA

AAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAA SEQ ID NO: 603

[00644] Construct pJAQ225 [AdF35 Genscript Codon Optimized Targeting

Domain]-[SGGSx3.1 Linker] -[ VS V-G mut del SP TM]

ATGACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTACGAGG

ACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCTAATGG

CTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTCTCACC

ACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGGACGAC

ACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCAAGAAC

AACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAACAACAA

GCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATCTGTAT

CAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATTGCCAG

ATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGGTTAAG

AACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATACAGTG

AACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTCGACT

CCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAAAACA

AGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATGCCTA

GCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTACATCC

ACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGAACAT

TAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCATCCA

GTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCACACT

GACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACAGCGGTGGG

AGCGGCGGGAGCGGCGGTAGCAAGTTCACCATAGTTTTTCCACACAACCAAAAA

GGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATT

TAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGA

GTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCAC

TACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCC

TTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGA

ACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGG ATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATA

CACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACAT

ATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGG

CTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAG

AGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTT

ATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCA

GACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGC

CAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCA

GTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCC

AAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCA

GCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGG

TACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATC

CTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGG

GATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGG

ACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACT

CCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGA

CGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTAT

CCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTAT

TGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGT

TGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACA

GACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 604

[00645] Construct pJAQ226 [TPO Genscript Optimized Targeting Domain]- [SGGSx3.1 Linker]-[VSV-G mut del SP TM]

ATGGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAGGCTGA

CCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAGCTGCT GAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGCACCCT

CTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTGGAAGA

CCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGC

TTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCCAGCCT

GCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAGAGCCT

GCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGACCCCAA

CGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTCTGATG

CTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGCCGTGC

CCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACGAGCG

GCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGTCTGCT

GAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAGACATC

TAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGCTGAA

CGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTCCTGAT

ATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAACCTGGA

TATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCCTCTGC

CTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGACCCTAG

CGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACACACAGC

CAGAACCTGTCTCAGGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCAA

GTTCACCATAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCT

AATTACCATTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAG

GCACAGCCTTACAAGTCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACG

GTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGG

ACCGAAGTATATAACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGC

AAGGAAAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCT

CCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAG

GTGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCAC

AGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTAC

AACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCC

ATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAG

GGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGC

AAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTC

GAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAG

GGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGA CGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAG

AGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCA

GGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCA

GATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGAT

CAGTGGAACTACCACAGAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGA

CGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCT

TTATACATGATTGGACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGG

CTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGA

TGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTA

GAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGG

GTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAAT

TAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTG

GAAAG SEQ ID NO: 605

[00646] Construct pJAQ227 [SCF full Targeting Domain]-[SGGSx3.2 Linker]- [VSV-G mut del SP TM]

ATGAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGT

TTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACG

TGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCC

TGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGA

TGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACAT

TTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGA

CGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTT

CAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAAC

CGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCG

TGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGC

CATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTC TAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTAT

GGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATT

GGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAAC

GAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGA

GGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTTTTCC

ACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCG

TCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCA

AAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTC

CAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACAT

TCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAA

CGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGC

AACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTG

GTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGC

AGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATA

AGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTC

AGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTA

ACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGC

ATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCT

CTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCA

TCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATT

ATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCC

AGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACC

ATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTG

CTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAG

CGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATG

GAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGG

TATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCT

CACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGA

TACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGG

AAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTT

GGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGA

CAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGSEQ ID NO: 606 [00647] Construct pJAQ228 [CD8a Signal Peptide]-[SCF soluble mutant

(V49L/F63L/K91E) Targeting Domain]-[SGGSx3.2 Linker] -[ VS V-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGA

CAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGC

CTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCT

GAGCGATTCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTG

AGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAG

TGCGTGGAGGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAG

CCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACG

CCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCAC

CCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCT

CCTGTGGCCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCAAGTTCACCATA

GTTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATT

ATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTT

ACAAGTCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTG

TCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTAT

ATAACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCA

TTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTT

GTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTC

ACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAA

CGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCAT

TCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCA

CCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGT

TCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAAT ACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTG

ATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTAT

CTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGG

ATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTC

CAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCC

TGCTTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGA

GTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTA

CCACAGAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTG

GACCCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGAT

TGGACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTC

GAACATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTAT

TTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTT

CAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTG

GACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACC

AAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG

SEQ ID NO: 607

[00648] Construct pJAQ229 [VSV-G Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.2 Linker]-[VSV-G mut del SP TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAAAAAA

CCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAACCCTCTG

GTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGT

GACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGT

GCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCA

GCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGC

CTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTT GAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCC

GAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCG

ACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAG

CACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTG

CCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAGAAAG

GCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCTGCCT

GCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAGAAAA

GACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGAAGATA

ACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGAGCGGT

GGGAGCGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTTTTCCACACAACCAA

AAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAG

ATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCA

GAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTC

ACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGAT

CCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAG

GAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGAC

GGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAA

TACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTAC

ATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAG

GGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGG

AGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGC

TTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGT

CAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCA

GCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCT

CAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTG

CCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCT

CAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAAT

GGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAA

TCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGT

GGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGA

GGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGA

CTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAA

GACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCT ATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCT

ATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGA

GTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATA

CAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 608

[00649] Construct pJAQ230 [SCF soluble Targeting Domain]-[SGGSx3.2 Linker]-

[VSV-G mut del SP TM]

ATGGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAA

GCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGC

ATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGC

GATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCA

ATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGT

GAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAG

ACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTT

AAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGT

CCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGT

GGCCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTTT

TCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGC

CCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAG

TCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATG

CTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAAC

ACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAA

CAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGA

TATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATG

TGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAA

AATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGA

CTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTC TTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGA

AGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGC

AAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAG

GATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTG

CTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTT

GGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATC

TCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTT

TCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGA

TATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACA

GAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCC

AATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGAC

ATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACA

TCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTG

GTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAG

TTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTAT

TCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAA

AAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 609

[00650] Construct pJAQ232 [CD8a Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain]-[SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker]-[CD43 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTA CGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCT

AATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTC

TCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGG

ACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCA

AGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAAC

AACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATC

TGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATT

GCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGG

TTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATAC

AGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTC

GACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAA

AACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATG

CCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTAC

ATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGA

ACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCA

TCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCA

CACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACAGCGG

TGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTAC

ACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGA

CCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCT

GGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCT

GTACTGCAGCGGTGGGAGCGGCATGCTGCCTGTGGCTGTGCTGGTGGCCCTGCTC

GCCGTGATCGTGCTGGTCGCCCTGCTGCTGCTGTGGCGGAGAAGACAGAAGAGA

CGGACC SEQ ID NO: 610

[00651] Construct pJAQ233 [CD8a Signal Peptide] -[AdF35 Genscript Codon Optimized Targeting Domain]-[SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker]- [CD49d.2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTA

CGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCT

AATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTC

TCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGG

ACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCA

AGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAAC

AACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATC

TGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATT

GCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGG

TTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATAC

AGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTC

GACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAA

AACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATG

CCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTAC

ATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGA

ACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCA

TCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCA

CACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACAGCGG

TGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTAC

ACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGA

CCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCT

GGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCT

GTACTGCAGCGGTGGGAGCATCGTGATCATCTCTAGCAGCCTGCTGCTGGGCCTG

ATCGTGCTGCTGCTGATCAGCTACGTGATGTGGAAGGCCGGCCTCTTCAAAAAAC

AGTACAAGTCC SEQ ID NO: 611 [00652] Construct pJAQ234 [CD8a Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain]-[SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker] -[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTA

CGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCT

AATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTC

TCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGG

ACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCA

AGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAAC

AACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATC

TGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATT

GCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGG

TTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATAC

AGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTC

GACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAA

AACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATG

CCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTAC

ATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGA

ACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCA

TCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCA

CACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACAGCGG

TGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTAC

ACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGA CCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCT

GGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCT

GTACTGCAGCGGTGGGAGCCCTCTGTTCATCCCCGTGGCCGTGATGGTGACCGCC

TTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGAAGACTGAAGAAGGGCAAG

AAATCTAAGCGG SEQ ID NO: 612

[00653] Construct pJAQ235 [CD8a Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain]-[SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker] -[CD 162 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTA

CGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCT

AATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTC

TCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGG

ACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCA

AGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAAC

AACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATC

TGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATT

GCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGG

TTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATAC

AGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTC

GACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAA

AACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATG CCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTAC

ATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGA

ACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCA

TCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCA

CACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACAGCGG

TGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTAC

ACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGA

CCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCT

GGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCT

GTACTGCAGCGGTGGGAGCCTGCTGGCTATCCTGATCCTGGCCCTGGTCGCCACA

ATCTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAGACTGAGCAGAAAGGGCCAC

ATGTACCCTGTGCGGAAC SEQ ID NO: 613

[00654] Construct pJAQ236 [CD8a Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain]-[SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker]-[HLA-

A2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTA

CGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCT

AATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTC

TCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGG

ACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCA

AGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAAC AACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATC

TGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATT

GCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGG

TTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATAC

AGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTC

GACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAA

AACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATG

CCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTAC

ATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGA

ACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCA

TCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCA

CACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACAGCGG

TGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTAC

ACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGA

CCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCT

GGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCT

GTACTGCAGCGGTGGGAGCATCGTGGGCATCATCGCCGGACTGGTGCTGTTCGG

CGCCGTCATCACCGGCGCTGTGGTGGCCGCCGTGATGTGGCGGAGAAAGTCTAG

CGACAGAAAGGGC SEQ ID NO: 614

[00655] Construct pJAQ237 [CD8a Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain]-[SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker]-[HLA- DRA TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTA

CGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCT

AATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTC

TCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGG

ACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCA

AGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAAC

AACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATC

TGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATT

GCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGG

TTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATAC

AGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTC

GACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAA

AACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATG

CCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTAC

ATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGA

ACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCA

TCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCA

CACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACAGCGG

TGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTAC

ACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGA

CCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCT

GGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCT

GTACTGCAGCGGTGGGAGCAACGTGGTGTGCGCCCTGGGCCTGACCGTGAGCCT

GGTCGGCATCATCATTGGAACAATCTTCATCATCAAGGGCCTGAGAAAGAGCAA

CGCCGCTGAGCGGAGAGGCCCTCTG SEQ ID NO: 615

[00656] Construct pJAQ238 [CD8a Signal Peptide] -[AdF35 Genscript Codon Optimized Targeting Domain]-[SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker]- [ICAM1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTA

CGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCT

AATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTC

TCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGG

ACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCA

AGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAAC

AACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATC

TGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATT

GCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGG

TTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATAC

AGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTC

GACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAA

AACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATG

CCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTAC

ATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGA

ACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCA

TCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCA

CACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACAGCGG

TGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTAC

ACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGA

CCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCT

GGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCT

GTACTGCAGCGGTGGGAGCATCGTGATCATCACCGTGGTCGCCGCCGCTGTGATC

ATGGGCACAGCCGGCCTGAGCACCTACCTGTACAACAGACAGAGAAAGATCAAG

AAATACCGGCTG SEQ ID NO: 616 [00657] Construct pJAQ240 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]-

[SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker]-[CD43 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

AGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCA

CCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCT

GTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTA

CATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATC

ACCCTGTACTGCAGCGGTGGGAGCGGCATGCTGCCTGTGGCTGTGCTGGTGGCCC

TGCTCGCCGTGATCGTGCTGGTCGCCCTGCTGCTGCTGTGGCGGAGAAGACAGAA

GAGACGGACC SEQ ID NO: 617

[00658] Construct pJAQ241 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]-

[SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker]-[CD49d.2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

AGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCA

CCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCT

GTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTA

CATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATC

ACCCTGTACTGCAGCGGTGGGAGCATCGTGATCATCTCTAGCAGCCTGCTGCTGG

GCCTGATCGTGCTGCTGCTGATCAGCTACGTGATGTGGAAGGCCGGCCTCTTCAA

AAAACAGTACAAGTCC SEQ ID NO: 618

[00659] Construct pJAQ242 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]-

[SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker] -[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

AGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCA

CCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCT

GTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTA

CATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATC

ACCCTGTACTGCAGCGGTGGGAGCCCTCTGTTCATCCCCGTGGCCGTGATGGTGA

CCGCCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGAAGACTGAAGAAGGG

CAAGAAATCTAAGCGG SEQ ID NO: 619

[00660] Construct pJAQ243 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]-

[SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker] - [CD 162 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

AGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCA

CCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCT

GTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTA

CATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATC

ACCCTGTACTGCAGCGGTGGGAGCCTGCTGGCTATCCTGATCCTGGCCCTGGTCG CCACAATCTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAGACTGAGCAGAAAGG

GCCACATGTACCCTGTGCGGAAC SEQ ID NO: 620

[00661] Construct pJAQ244 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain] -[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker]-[CD43 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC

CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG

AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT

CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG

ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC

TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC

CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGT

AGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCC

AGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAG

AGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGC

GGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCGGCA

TGCTGCCTGTGGCTGTGCTGGTGGCCCTGCTCGCCGTGATCGTGCTGGTCGCCCT

GCTGCTGCTGTGGCGGAGAAGACAGAAGAGACGGACC SEQ ID NO: 621

[00662] Construct pJAQ245 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain] -[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker]-[CD49d.2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG

AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT

CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG

ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC

TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC

CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC

TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGT

AGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCC

AGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAG

AGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGC

GGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCATCG

TGATCATCTCTAGCAGCCTGCTGCTGGGCCTGATCGTGCTGCTGCTGATCAGCTA

CGTGATGTGGAAGGCCGGCCTCTTCAAAAAACAGTACAAGTCC SEQ ID NO: 622

[00663] Construct pJAQ246 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain] -[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC

CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG

AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT

CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG

ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC

TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC

CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC

TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGT

AGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCC

AGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAG

AGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGC

GGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCCCTC

TGTTCATCCCCGTGGCCGTGATGGTGACCGCCTTCAGCGGCCTGGCTTTTATCATC

TGGCTGGCCAGAAGACTGAAGAAGGGCAAGAAATCTAAGCGG SEQ ID NO: 623

[00664] Construct pJAQ247 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain] -[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[CD 162 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC

CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG

AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT

CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG

ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC

TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC

CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC

TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGT

AGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCC

AGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAG

AGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGC

GGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCCTGC

TGGCTATCCTGATCCTGGCCCTGGTCGCCACAATCTTCTTCGTGTGCACCGTGGTG

CTGGCCGTGAGACTGAGCAGAAAGGGCCACATGTACCCTGTGCGGAAC

SEQ ID NO: 624 [00665] Construct pJAQ248 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain] -[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[HLA-A2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC

CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG

AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT

CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG

ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC

TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC

CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC

TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGT

AGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCC AGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAG

AGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGC

GGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCATCG

TGGGCATCATCGCCGGACTGGTGCTGTTCGGCGCCGTCATCACCGGCGCTGTGGT

GGCCGCCGTGATGTGGCGGAGAAAGTCTAGCGACAGAAAGGGC SEQ ID

NO: 625

[00666] Construct pJAQ249 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain] -[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[HLA-DRA TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC

CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG

AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT

CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC

TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC

CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC

TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGT

AGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCC

AGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAG

AGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGC

GGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCAACG

TGGTGTGCGCCCTGGGCCTGACCGTGAGCCTGGTCGGCATCATCATTGGAACAAT

CTTCATCATCAAGGGCCTGAGAAAGAGCAACGCCGCTGAGCGGAGAGGCCCTCT G SEQ ID NO: 626

[00667] Construct pJAQ250 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain] -[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC

CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG

AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT

CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG

ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC

TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC

CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC

TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGT

AGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCC

AGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAG

AGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGC

GGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCATCG

TGATCATCACCGTGGTCGCCGCCGCTGTGATCATGGGCACAGCCGGCCTGAGCAC

CTACCTGTACAACAGACAGAGAAAGATCAAGAAATACCGGCTG SEQ ID NO: 627

[00668] Construct pJAQ251 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain] -[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[LFA-1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC

CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG

AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT

CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG

ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC

TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC

CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC

TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGT

AGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCC

AGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAG

AGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGC

GGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCTACC

TGTACGTGCTGAGCGGCATCGGCGGACTGCTGCTGCTGCTCCTGATCTTCATCGT

GCTGTACAAGGTGGGCTTTTTCAAAAGAAACCTGAAG SEQ ID NO: 628

[00669] Construct pJAQ252 [CD8a Signal Peptide]-[TPO trunc 157 Targeting

Domain]-[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker]-[CD43 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGAGCGGTGGGAGCGGCG

GGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTA

CCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGC

CGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTG

GCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCG

GTGGGAGCGGCATGCTGCCTGTGGCTGTGCTGGTGGCCCTGCTCGCCGTGATCGT

GCTGGTCGCCCTGCTGCTGCTGTGGCGGAGAAGACAGAAGAGACGGACC

SEQ ID NO: 629

[00670] Construct pJAQ253 [CD8a Signal Peptide]-[TPO trunc 157 Targeting

Domain]-[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[CD49d.2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGAGCGGTGGGAGCGGCG

GGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTA

CCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGC

CGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTG

GCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCG

GTGGGAGCATCGTGATCATCTCTAGCAGCCTGCTGCTGGGCCTGATCGTGCTGCT

GCTGATCAGCTACGTGATGTGGAAGGCCGGCCTCTTCAAAAAACAGTACAAGTC

C SEQ ID NO: 630

[00671] Construct pJAQ254 [CD8a Signal Peptide]-[TPO trunc 157 Targeting

Domain]-[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[CD 162 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGAGCGGTGGGAGCGGCG

GGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTA

CCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGC

CGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTG

GCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCG

GTGGGAGCCTGCTGGCTATCCTGATCCTGGCCCTGGTCGCCACAATCTTCTTCGT

GTGCACCGTGGTGCTGGCCGTGAGACTGAGCAGAAAGGGCCACATGTACCCTGT

GCGGAAC SEQ ID NO: 631

[00672] Construct pJAQ255 [CD8a Signal Peptide]-[TPO trunc 157 Targeting

Domain]-[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGAGCGGTGGGAGCGGCG

GGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTA

CCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGC

CGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTG

GCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCG

GTGGGAGCCCTCTGTTCATCCCCGTGGCCGTGATGGTGACCGCCTTCAGCGGCCT

GGCTTTTATCATCTGGCTGGCCAGAAGACTGAAGAAGGGCAAGAAATCTAAGCG

G SEQ ID NO: 632

[00673] Construct pJAQ256 [CD8a Signal Peptide]-[TPO trunc 157 Targeting

Domain]-[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[HLA-A2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGAGCGGTGGGAGCGGCG

GGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTA

CCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGC

CGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTG

GCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCG

GTGGGAGCATCGTGGGCATCATCGCCGGACTGGTGCTGTTCGGCGCCGTCATCAC

CGGCGCTGTGGTGGCCGCCGTGATGTGGCGGAGAAAGTCTAGCGACAGAAAGGG

C SEQ ID NO: 633

[00674] Construct pJAQ257 [CD8a Signal Peptide]-[TPO trunc 157 Targeting

Domain]-[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[HLA-DRA TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGAGCGGTGGGAGCGGCG

GGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTA

CCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGC CGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTG

GCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCG

GTGGGAGCAACGTGGTGTGCGCCCTGGGCCTGACCGTGAGCCTGGTCGGCATCA

TCATTGGAACAATCTTCATCATCAAGGGCCTGAGAAAGAGCAACGCCGCTGAGC

GGAGAGGCCCTCTG SEQ ID NO: 634

[00675] Construct pJAQ258 [CD8a Signal Peptide]-[TPO trunc 157 Targeting

Domain]-[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGAGCGGTGGGAGCGGCG

GGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTA

CCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGC

CGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTG

GCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCG

GTGGGAGCATCGTGATCATCACCGTGGTCGCCGCCGCTGTGATCATGGGCACAG CCGGCCTGAGCACCTACCTGTACAACAGACAGAGAAAGATCAAGAAATACCGGC

TG SEQ ID NO: 635

[00676] Construct pJAQ259 [CD8a Signal Peptide]-[TPO trunc 157 Targeting

Domain]-[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[LFA-1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGAGCGGTGGGAGCGGCG

GGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTA

CCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTGC

CGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCTG

GCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGCG

GTGGGAGCTACCTGTACGTGCTGAGCGGCATCGGCGGACTGCTGCTGCTGCTCCT

GATCTTCATCGTGCTGTACAAGGTGGGCTTTTTCAAAAGAAACCTGAAG

SEQ ID NO: 636 [00677] Construct pJAQ260 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]-

[SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker] - [HLA-A2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

AGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCA

CCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCT

GTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTA

CATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATC

ACCCTGTACTGCAGCGGTGGGAGCATCGTGGGCATCATCGCCGGACTGGTGCTGT

TCGGCGCCGTCATCACCGGCGCTGTGGTGGCCGCCGTGATGTGGCGGAGAAAGT

CTAGCGACAGAAAGGGCSEQ ID NO: 637

[00678] Construct pJAQ261 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]-

[SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker] -[HLA-DRA TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

AGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCA

CCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCT

GTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTA

CATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATC

ACCCTGTACTGCAGCGGTGGGAGCAACGTGGTGTGCGCCCTGGGCCTGACCGTG

AGCCTGGTCGGCATCATCATTGGAACAATCTTCATCATCAAGGGCCTGAGAAAG

AGCAACGCCGCTGAGCGGAGAGGCCCTCTG SEQ ID NO: 638

[00679] Construct pJAQ262 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]-

[SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG AGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCA

CCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCT

GTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTA

CATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATC

ACCCTGTACTGCAGCGGTGGGAGCATCGTGATCATCACCGTGGTCGCCGCCGCTG

TGATCATGGGCACAGCCGGCCTGAGCACCTACCTGTACAACAGACAGAGAAAGA

TCAAGAAATACCGGCTG SEQ ID NO: 639

[00680] Construct pJAQ263 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]-

[SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker] -[LF A- 1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

AGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCA

CCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCT

GTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTA

CATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATC

ACCCTGTACTGCAGCGGTGGGAGCTACCTGTACGTGCTGAGCGGCATCGGCGGA

CTGCTGCTGCTGCTCCTGATCTTCATCGTGCTGTACAAGGTGGGCTTTTTCAAAAG

AAACCTGAAG SEQ ID NO: 640 [00681] Construct pJAQ264 [SCF soluble mutant (V49L/F63L) Targeting Domain]- [SGGSx3.2 Linker]-[VSV-G mut del SP TM]

ATGGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAA

GCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGC

ATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGC

GATTCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCA

ATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGT

GAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAG

ACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTT

AAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGT

CCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGT

GGCCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTTT

TCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGC

CCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAG

TCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATG

CTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAAC

ACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAA

CAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGA

TATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATG

TGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAA

AATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGA

CTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTC

TTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGA

AGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGC

AAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAG

GATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTG CTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTT

GGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATC

TCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTT

TCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGA

TATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACA

GAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCC

AATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGAC

ATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACA

TCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTG

GTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAG

TTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTAT

TCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAA

AAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 641

[00682] Construct pJAQ265 [SCF soluble mutant (V49L/F63L/K9 IE) Targeting

Domain]-[SGGSx3.2 Einker] -[ VS V-G mut del SP TM]

ATGGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAA

GCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGC

ATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGC

GATTCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCA

ATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGT

GGAGGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAG

ACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTT

AAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGT

CCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGT

GGCCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTTT TCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGC

CCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAG

TCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATG

CTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAAC

ACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAA

CAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGA

TATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATG

TGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAA

AATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGA

CTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTC

TTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGA

AGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGC

AAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAG

GATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTG

CTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTT

GGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATC

TCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTT

TCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGA

TATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACA

GAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCC

AATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGAC

ATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACA

TCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTG

GTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAG

TTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTAT

TCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAA

AAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 642

[00683] Construct pJAQ266 [SCF soluble mutant (V49L/F63L/K91E/I98R)

Targeting Domain] -[SGGSx3.2 Einker] -[ VS V-G mut del SP TM]

ATGGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAA

GCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGC

ATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGC

GATTCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCA

ATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGT

GGAGGAGAACAGCTCCAAGGACCGGAAAAAGTCTTTCAAGAGCCCCGAGCCAA

GACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTT

TAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTG

TCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTG

TGGCCGCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCAAGTTCACCATAGTTT

TTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTG

CCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAA

GTCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCAT

GCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAA

CACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGA

ACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGG

ATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCAT

GTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGA

AAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTG

ACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTT

CTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAG

AAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTG

CAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAA

GGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCT

GCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCT

TGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAAT

CTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCT

TTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCG ATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCAC

AGAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACC

CAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGA

CATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAAC

ATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTT

GGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTA

GTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTA

TTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGA

AAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID

NO: 643

[00684] Construct pJAQ267 [CD8a Signal Peptide]-[SCF soluble Targeting

Domain]-[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker]-[CD43 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGA

CAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGC

CTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGC

TGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCT

GAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGA

GTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGA

GCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGAC

GCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCA

CCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCC

TCCTGTGGCCGCCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCC TGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTG

CGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTC

GCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGC

TCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCGGCATGCTGCCTGTGGC

TGTGCTGGTGGCCCTGCTCGCCGTGATCGTGCTGGTCGCCCTGCTGCTGCTGTGG

CGGAGAAGACAGAAGAGACGGACC SEQ ID NO: 644

[00685] Construct pJAQ268 [CD8a Signal Peptide]-[SCF soluble Targeting

Domain]-[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGA

CAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGC

CTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGC

TGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCT

GAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGA

GTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGA

GCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGAC

GCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCA

CCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCC

TCCTGTGGCCGCCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCC

TGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTG

CGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTC

GCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGC

TCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCCCTCTGTTCATCCCCGT GGCCGTGATGGTGACCGCCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGA

AGACTGAAGAAGGGCAAGAAATCTAAGCGG SEQ ID NO: 645

[00686] Construct pJAQ269 [CD8a Signal Peptide]-[SCF soluble Targeting

Domain]-[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[CD49d.2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGA

CAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGC

CTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGC

TGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCT

GAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGA

GTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGA

GCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGAC

GCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCA

CCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCC

TCCTGTGGCCGCCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCC

TGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTG

CGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTC

GCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGC

TCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCATCGTGATCATCTCTAG

CAGCCTGCTGCTGGGCCTGATCGTGCTGCTGCTGATCAGCTACGTGATGTGGAAG

GCCGGCCTCTTCAAAAAACAGTACAAGTCC SEQ ID NO: 646 [00687] Construct pJAQ270 [CD8a Signal Peptide]-[SCF soluble Targeting

Domain]-[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[HLA-A2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGA

CAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGC

CTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGC

TGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCT

GAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGA

GTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGA

GCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGAC

GCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCA

CCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCC

TCCTGTGGCCGCCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCC

TGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTG

CGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTC

GCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGC

TCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCATCGTGGGCATCATCGC

CGGACTGGTGCTGTTCGGCGCCGTCATCACCGGCGCTGTGGTGGCCGCCGTGATG

TGGCGGAGAAAGTCTAGCGACAGAAAGGGC SEQ ID NO: 647

[00688] Construct pJAQ271 [CD8a Signal Peptide]-[SCF soluble Targeting

Domain]-[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[HLA-DRA TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGA

CAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGC

CTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGC

TGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCT

GAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGA

GTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGA

GCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGAC

GCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCA

CCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCC

TCCTGTGGCCGCCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCC

TGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTG

CGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTC

GCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGC

TCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCAACGTGGTGTGCGCCCT

GGGCCTGACCGTGAGCCTGGTCGGCATCATCATTGGAACAATCTTCATCATCAAG

GGCCTGAGAAAGAGCAACGCCGCTGAGCGGAGAGGCCCTCTG SEQ ID NO: 648

[00689] Construct pJAQ272 [CD8a Signal Peptide]-[SCF soluble Targeting

Domain]-[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGA

CAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGC

CTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGC

TGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCT

GAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGA

GTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGA

GCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGAC

GCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCA

CCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCC

TCCTGTGGCCGCCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCC

TGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTG

CGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTC

GCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGC

TCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCATCGTGATCATCACCGT

GGTCGCCGCCGCTGTGATCATGGGCACAGCCGGCCTGAGCACCTACCTGTACAA

CAGACAGAGAAAGATCAAGAAATACCGGCTG SEQ ID NO: 649

[00690] Construct pJAQ273 [CD8a Signal Peptide]-[SCF soluble Targeting

Domain]-[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[LFA-1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGA CAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGC

CTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGC

TGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCT

GAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGA

GTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGA

GCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGAC

GCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCA

CCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCC

TCCTGTGGCCGCCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCC

TGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTG

CGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTC

GCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGC

TCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCTACCTGTACGTGCTGAG

CGGCATCGGCGGACTGCTGCTGCTGCTCCTGATCTTCATCGTGCTGTACAAGGTG

GGCTTTTTCAAAAGAAACCTGAAG SEQ ID NO: 650

[00691] Construct pJAQ274 [CD8a Signal Peptide]-[SCF soluble Targeting

Domain]-[SGGSx3.1 Linker]-[CD8a Hinge]-[SGGSxl Linker] -[CD 162 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGA

CAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGC

CTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGC

TGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCT

GAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGA GTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGA

GCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGAC

GCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCA

CCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCC

TCCTGTGGCCGCCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCC

TGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTG

CGGCCCGAGGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTC

GCCTGCGACATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGC

TCTCTCTGGTGATCACCCTGTACTGCAGCGGTGGGAGCCTGCTGGCTATCCTGAT

CCTGGCCCTGGTCGCCACAATCTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAGA

CTGAGCAGAAAGGGCCACATGTACCCTGTGCGGAAC SEQ ID NO: 651

[00692] Construct pJAQ280 [CD133 scFv 1 Targeting Domain]-[CD8 trunc Hinge]- [HLA-DRA TM]

ATGGCCGAGGTGCAGCTGCTGGAAAGCGGCGGAGGCCTGGTGCAGCCTGGCGGC

AGCCTGAGACTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCTCCTACGCCATGA

GCTGGGTTAGACAGGCCCCTGGCAAGGGCCTCGAGTGGGTCAGCGCCATCAGCA

GAACCGGCGGCGTGACCAGATACGCCGACAGCGTGAAGGGCAGATTCACCATCA

GCCGGGACAACTCAAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGCCG

AGGATACAGCCGTGTACTACTGCGCCAAGCGGACCAGGCGGTTCGACTACTGGT

GCCAGGGCACCCTGGTGACAGTGTCCAGCAGCCCCAGCTCCCTGTCTGCTTCTGT

GGGCGACAGAGTGACCATCACCTGCAGAGCCAGCCAGAGCATCAGCAGCTACCT

GAACTGGTACCAGCAGAAACCTGGAAAAGCCCCTAAGCTGCTGATCTACAGCGC

TTCTGATCTGCAATCCGGCGTGCCATCTAGATTTTCTGGCAGCGGATCTGGAACC

GATTTTACACTGACCATTTCCAGCCTGCAGCCCGAGGACTTCGCCACCTACTATT

GTCAGCAAACAGCTAATTCTCCTAGCACATTCGGCCAGGGAACAAAGGTGGAAA

TCACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCA GCCCCTGTCACTGCGCCCTGAAGCCTGTAACGTGGTGTGCGCCCTGGGCCTGACC

GTGAGCCTGGTCGGCATCATCATTGGAACAATCTTCATCATCAAGGGCCTGAGAA

AGAGCAACGCCGCTGAGCGGAGAGGCCCTCTG SEQ ID NO: 652

[00693] Construct pJAQ281 [CD133 scFv 2 Targeting Domain]-[CD8 trunc Hinge]- [HLA-A2 TM]

ATGGACATCGTGCTGAGCCAGAGCCCAGCTATCATGAGCGCCAGCCCTGGCGAG

AAGGTGACCATCAGCTGCAGCGCTAGCTCCAGCGTGTCTTACATGTACTGGTACC

AGCAAAAGCCCGGCTCTTCTCCAAAGCCCTGGATCTACCGGACCTCTAATCTGGC

CTCTGGCGTGCCCGCCAGATTTTCTGGCAGCGGCAGCGGAACCAGCTACAGCCTG

ACAATCAGCAGCATGGAAGCCGAGGATGCCGCTACCTACTACTGCCAGCAGTAC

CACAGCTACCCTCCTACCTTCGGCGCCGGCACAAAGCTGGAACTGAAAAGCTCC

GGCGGTGGAGGCAGCGGAGGCGGCGGCGGCGGAAGCTCTAGAAGCAGCCTGGA

AGTGAAACTGGTGGAAAGCGGCCCTGAGCTGAAGAAGCCTGGAGAAACCGTGA

AGATCTCCTGTAAAGCCAGCGGCTATACATTTACCGATTACAGCATGAAGTGGGT

CAACCAGGCCCCTGGCAAGGGCCTGAAGTGGATGGGCTGGATTAACACCGAGAC

CGGCGAGCCTAGCTACGCCGACGACTTCAAGGGCAGATTCGCCTTCAGCCTCGA

GACATCTGCTAGCACCGCCTACCTGCAGATCAACAACCTGAAGAACGAGGACAC

CGCCACATACTTCTGCGCCACCGACTATGGCGATTACTTCGACTACTGGGGCCAG

GGAACAACACTGACCGTGTCCTCCACTACAACTCCAGCACCCAGACCCCCTACAC

CTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATCGT

GGGCATCATCGCCGGACTGGTGCTGTTCGGCGCCGTCATCACCGGCGCTGTGGTG

GCCGCCGTGATGTGGCGGAGAAAGTCTAGCGACAGAAAGGGC SEQ ID NO: 653 [00694] Construct pJAQ282 [CD133 scFv 2 Targeting Domain]-[CD8 trunc Hinge]-

[LFA-1 TM]

ATGGACATCGTGCTGAGCCAGAGCCCAGCTATCATGAGCGCCAGCCCTGGCGAG

AAGGTGACCATCAGCTGCAGCGCTAGCTCCAGCGTGTCTTACATGTACTGGTACC

AGCAAAAGCCCGGCTCTTCTCCAAAGCCCTGGATCTACCGGACCTCTAATCTGGC

CTCTGGCGTGCCCGCCAGATTTTCTGGCAGCGGCAGCGGAACCAGCTACAGCCTG

ACAATCAGCAGCATGGAAGCCGAGGATGCCGCTACCTACTACTGCCAGCAGTAC

CACAGCTACCCTCCTACCTTCGGCGCCGGCACAAAGCTGGAACTGAAAAGCTCC

GGCGGTGGAGGCAGCGGAGGCGGCGGCGGCGGAAGCTCTAGAAGCAGCCTGGA

AGTGAAACTGGTGGAAAGCGGCCCTGAGCTGAAGAAGCCTGGAGAAACCGTGA

AGATCTCCTGTAAAGCCAGCGGCTATACATTTACCGATTACAGCATGAAGTGGGT

CAACCAGGCCCCTGGCAAGGGCCTGAAGTGGATGGGCTGGATTAACACCGAGAC

CGGCGAGCCTAGCTACGCCGACGACTTCAAGGGCAGATTCGCCTTCAGCCTCGA

GACATCTGCTAGCACCGCCTACCTGCAGATCAACAACCTGAAGAACGAGGACAC

CGCCACATACTTCTGCGCCACCGACTATGGCGATTACTTCGACTACTGGGGCCAG

GGAACAACACTGACCGTGTCCTCCACTACAACTCCAGCACCCAGACCCCCTACAC

CTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTTACCT

GTACGTGTTGAGCGGCATCGGCGGACTGCTGCTGCTGCTCCTGATCTTCATCGTG

CTGTACAAGGTGGGCTTTTTCAAAAGAAACCTGAAG SEQ ID NO: 654

[00695] Construct pJAQ283 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]-

[CD8 trunc Hinge] -[CD43 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

ACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGC

CCCTGTCACTGCGCCCTGAAGCCTGTGGCATGCTGCCTGTGGCTGTGCTGGTGGC

CCTGCTCGCCGTGATCGTGCTGGTCGCCCTGCTGCTGCTGTGGCGGAGAAGACAG

AAGAGACGGACC SEQ ID NO: 655

[00696] Construct pJAQ284 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]-

[CD8 trunc Hinge] -[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

ACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGC

CCCTGTCACTGCGCCCTGAAGCCTGTCCTCTGTTCATCCCCGTGGCCGTGATGGT

GACCGCCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGAAGACTGAAGAAG

GGCAAGAAATCTAAGCGG SEQ ID NO: 656 [00697] Construct pJAQ285 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]- [CD8 trunc Hinge] -[HLA-A2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

ACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGC

CCCTGTCACTGCGCCCTGAAGCCTGTATCGTGGGCATCATCGCCGGACTGGTGCT

GTTCGGCGCCGTCATCACCGGCGCTGTGGTGGCCGCCGTGATGTGGCGGAGAAA

GTCTAGCGACAGAAAGGGC SEQ ID NO: 657

[00698] Construct pJAQ286 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]- [CD8 trunc Hinge] -[LFA-1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

ACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGC

CCCTGTCACTGCGCCCTGAAGCCTGTTACCTGTACGTGTTGAGCGGCATCGGCGG

ACTGCTGCTGCTGCTCCTGATCTTCATCGTGCTGTACAAGGTGGGCTTTTTCAAAA

GAAACCTGAAG SEQ ID NO: 658

[00699] Construct pJAQ287 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain] -[CD 8 trunc Hinge] -[CD 162 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC

CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG

AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT

CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG

ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC

TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC

TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCACTACAACTCCAGCACCCAGACCCCCTA

CACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTCT

GCTGGCTATCCTGATCCTGGCCCTGGTCGCCACAATCTTCTTCGTGTGCACCGTG

GTGCTGGCCGTGAGACTGAGCAGAAAGGGCCACATGTACCCTGTGCGGAAC

SEQ ID NO: 659

[00700] Construct pJAQ288 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain] -[CD 8 trunc Hinge] -[CD43 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC

CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG

AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT

CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC

TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC

CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC

TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCACTACAACTCCAGCACCCAGACCCCCTA

CACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTGG

CATGCTGCCTGTGGCTGTGCTGGTGGCCCTGCTCGCCGTGATCGTGCTGGTCGCC

CTGCTGCTGCTGTGGCGGAGAAGACAGAAGAGACGGACC SEQ ID NO: 660

[00701] Construct pJAQ289 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain]-[CD8 trunc Hinge]-[CD49d.2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC

CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT

CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG

ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC

TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC

CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC

TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCACTACAACTCCAGCACCCAGACCCCCTA

CACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTAT

CGTGATCATCTCTAGCAGCCTGCTGCTGGGCCTGATCGTGCTGCTGCTGATCAGC

TACGTGATGTGGAAGGCCGGCCTCTTCAAAAAACAGTACAAGTCC SEQ ID

NO: 661

[00702] Construct pJAQ290 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain]-[CD8 trunc Hinge] -[HLA-A2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC

CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG

AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT

CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG

ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC

TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC

CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC

TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCACTACAACTCCAGCACCCAGACCCCCTA

CACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTAT

CGTGGGCATCATCGCCGGACTGGTGCTGTTCGGCGCCGTCATCACCGGCGCTGTG

GTGGCCGCCGTGATGTGGCGGAGAAAGTCTAGCGACAGAAAGGGC SEQ ID NO: 662

[00703] Construct pJAQ291 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [CD8 trunc Hinge] -[CD49d.2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGC

AAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATCGTGATCATCTCTAGCAGC

CTGCTGCTGGGCCTGATCGTGCTGCTGCTGATCAGCTACGTGATGTGGAAGGCCG

GCCTCTTCAAAAAACAGTACAAGTCC SEQ ID NO: 663

[00704] Construct pJAQ292 [CD8a Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain]-[CD8 trunc Hinge]-[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTA

CGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCT

AATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTC

TCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGG

ACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCA

AGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAAC

AACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATC

TGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATT GCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGG

TTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATAC

AGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTC

GACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAA

AACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATG

CCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTAC

ATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGA

ACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCA

TCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCA

CACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACACTAC

AACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTG

TCACTGCGCCCTGAAGCCTGTCCTCTGTTCATCCCCGTGGCCGTGATGGTGACCG

CCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGAAGACTGAAGAAGGGCA

AGAAATCTAAGCGG SEQ ID NO: 664

[00705] Construct pJAQ293 [CD8a Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTA

CGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCT

AATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTC

TCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGG

ACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCA

AGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAAC

AACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATC TGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATT

GCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGG

TTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATAC

AGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTC

GACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAA

AACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATG

CCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTAC

ATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGA

ACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCA

TCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCA

CACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACACTAC

AACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTG

TCACTGCGCCCTGAAGCCTGTATCGTGATCATCACCGTGGTCGCCGCCGCTGTGA

TCATGGGCACAGCCGGCCTGAGCACCTACCTGTACAACAGACAGAGAAAGATCA

AGAAATACCGGCTG SEQ ID NO: 665

[00706] Construct pJAQ294 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]-

[CD8 trunc Hinge] -[CD43 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

ACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGC

CCCTGTCACTGCGCCCTGAAGCCTGTGGCATGCTGCCTGTGGCTGTGCTGGTGGC CCTGCTCGCCGTGATCGTGCTGGTCGCCCTGCTGCTGCTGTGGCGGAGAAGACAG

AAGAGACGGACC SEQ ID NO: 666

[00707] Construct pJAQ295 [B2M Signal Peptide]-[SCF full Targeting Domain]- [CD8 trunc Hinge] -[CD 162 TM]

ATGAGCAGAAGCGTGGCCCTGGCCGTGCTGGCTCTGCTGTCTCTGTCCGGCCTGG

AGGCCAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCT

GTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAA

CGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCAC

CCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGA

GATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAA

CATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTG

GACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCT

TTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCA

ACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTG

CGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAA

GCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGC

TCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCT

ATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTA

TTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAA

CGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGG

AGGTGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAG

TCAGCCCCTGTCACTGCGCCCTGAAGCCTGTCTGCTGGCTATCCTGATCCTGGCC

CTGGTCGCCACAATCTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAGACTGAGCA

GAAAGGGCCACATGTACCCTGTGCGGAAC SEQ ID NO: 667 [00708] Construct pJAQ296 [B2M Signal Peptide]-[SCF full Targeting Domain]- [CD8 trunc Hinge] -[CD49d.2 TM]

ATGAGCAGAAGCGTGGCCCTGGCCGTGCTGGCTCTGCTGTCTCTGTCCGGCCTGG AGGCCAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCT GTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAA CGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCAC CCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGA GATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAA CATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTG GACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCT TTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCA ACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTG CGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAA GCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGC TCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCT ATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTA

TTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAA

CGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGG

AGGTGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAG

TCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATCGTGATCATCTCTAGCAGCCTG CTGCTGGGCCTGATCGTGCTGCTGCTGATCAGCTACGTGATGTGGAAGGCCGGCC

TCTTCAAAAAACAGTACAAGTCC SEQ ID NO: 668

[00709] Construct pJAQ297 [B2M Signal Peptide]-[SCF full Targeting Domain]-

[CD8 trunc Hinge] -[CD62L TM]

ATGAGCAGAAGCGTGGCCCTGGCCGTGCTGGCTCTGCTGTCTCTGTCCGGCCTGG

AGGCCAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCT

GTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAA

CGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCAC

CCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGA

GATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAA

CATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTG

GACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCT

TTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCA

ACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTG

CGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAA

GCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGC

TCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCT

ATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTA

TTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAA

CGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGG

AGGTGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAG

TCAGCCCCTGTCACTGCGCCCTGAAGCCTGTCCTCTGTTCATCCCCGTGGCCGTG

ATGGTGACCGCCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGAAGACTGA

AGAAGGGCAAGAAATCTAAGCGG SEQ ID NO: 669

[00710] Construct pJAQ298 [B2M Signal Peptide]-[SCF full Targeting Domain]-

[CD8 trunc Hinge] -[HLA-DRA TM]

ATGAGCAGAAGCGTGGCCCTGGCCGTGCTGGCTCTGCTGTCTCTGTCCGGCCTGG

AGGCCAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCT

GTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAA

CGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCAC

CCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGA

GATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAA

CATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTG

GACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCT

TTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCA

ACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTG

CGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAA

GCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGC

TCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCT

ATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTA

TTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAA

CGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGG

AGGTGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAG

TCAGCCCCTGTCACTGCGCCCTGAAGCCTGTAACGTGGTGTGCGCCCTGGGCCTG

ACCGTGAGCCTGGTCGGCATCATCATTGGAACAATCTTCATCATCAAGGGCCTGA

GAAAGAGCAACGCCGCTGAGCGGAGAGGCCCTCTG SEQ ID NO: 670

[00711] Construct pJAQ299 [B2M Signal Peptide]-[SCF full Targeting Domain]- [CD8 trunc Hinge] -[ICAM1 TM]

ATGAGCAGAAGCGTGGCCCTGGCCGTGCTGGCTCTGCTGTCTCTGTCCGGCCTGG

AGGCCAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCT

GTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAA

CGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCAC

CCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGA

GATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAA

CATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTG

GACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCT

TTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCA

ACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTG

CGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAA

GCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGC

TCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCT

ATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTA

TTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAA

CGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGG

AGGTGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAG

TCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATCGTGATCATCACCGTGGTCGCC

GCCGCTGTGATCATGGGCACAGCCGGCCTGAGCACCTACCTGTACAACAGACAG

AGAAAGATCAAGAAATACCGGCTG SEQ ID NO: 671

[00712] Construct pJAQ300 [B2M Signal Peptide]-[SCF full Targeting Domain]- [CD8 trunc Hinge] -[LFA-1 TM]

ATGAGCAGAAGCGTGGCCCTGGCCGTGCTGGCTCTGCTGTCTCTGTCCGGCCTGG

AGGCCAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCT

GTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAA CGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCAC

CCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGA

GATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAA

CATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTG

GACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCT

TTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCA

ACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTG

CGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAA

GCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGC

TCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCT

ATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTA

TTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAA

CGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGG

AGGTGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAG

TCAGCCCCTGTCACTGCGCCCTGAAGCCTGTTACCTGTACGTGTTGAGCGGCATC

GGCGGACTGCTGCTGCTGCTCCTGATCTTCATCGTGCTGTACAAGGTGGGCTTTTT

CAAAAGAAACCTGAAG SEQ ID NO: 672

[00713] Construct pJAQ301 [CD90 scFvl Targeting Domain]-[CD8 trunc Hinge]- [CD43 TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT

GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT

ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA

TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA

GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT

ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC

TAAATTGGAGTTGAAGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCA

ACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTGGCATGCTGCCTG

TGGCTGTGCTGGTGGCCCTGCTCGCCGTGATCGTGCTGGTCGCCCTGCTGCTGCT

GTGGCGGAGAAGACAGAAGAGACGGACC SEQ ID NO: 673

[00714] Construct pJAQ302 [CD90 scFvl Targeting Domain]-[CD8 trunc Hinge]- [CD49d.2 TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT

GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT

ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG

GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA

TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA

GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT

ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC

TAAATTGGAGTTGAAGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCA ACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATCGTGATCATCT

CTAGCAGCCTGCTGCTGGGCCTGATCGTGCTGCTGCTGATCAGCTACGTGATGTG

GAAGGCCGGCCTCTTCAAAAAACAGTACAAGTCC SEQ ID NO: 674

[00715] Construct pJAQ303 [Siglec 1 Targeting Domain]-[CD8 trunc Hinge]-[LFA- 1 TM]

ATGGGATTTCTGCCTAAGCTGCTGCTGCTGGCCTCTTTTTTCCCCGCCGGTCAAGC

TAGCTGGGGCGTGTCTTCTCCACAAGATGTGCAGGGCGTGAAGGGCAGCTGCCT

GCTCATCCCTTGCATCTTCAGCTTCCCTGCTGATGTCGAAGTGCCTGATGGCATCA

CAGCCATCTGGTACTACGACTACAGCGGCCAGAGACAGGTGGTGTCCCACAGCG

CCGACCCCAAACTGGTCGAGGCCAGATTTAGGGGCCGCACCGAGTTCATGGGCA

ACCCCGAGCACAGAGTGTGCAACCTGCTGCTTAAAGACCTGCAACCTGAGGACA

GCGGATCTTATAACTTCAGATTCGAAATTTCTGAGGTGAACCGGTGGAGCGACGT

GAAAGGCACCCTGGTTACCGTGACCGAGGAACCTAGAGTGCCCACCATCGCCTC

CCCTGTGGAACTGCTGGAAGGCACAGAAGTGGACTTCAACTGCAGCACCCCTTA

CGTGTGTCTGCAGGAGCAGGTGCGGCTGCAGTGGCAGGGCCAGGATCCTGCCAG

AAGCGTGACCTTCAATTCACAGAAGTTCGAGCCTACAGGCGTGGGACACCTGGA

AACACTGCACATGGCCATGAGCTGGCAGGACCACGGCAGAATCCTGAGATGCCA

GCTGAGCGTGGCCAACCACCGGGCCCAGAGCGAGATCCACCTGCAGGTGAAGTA

CGCCCCTAAGGGCGTGAAGATCCTGCTGAGTCCTAGCGGCCGGAACATCCTGCC

AGGCGAGCTGGTGACCCTGACATGCCAGGTTAATAGCAGCTACCCTGCTGTATCC

AGCATCAAGTGGCTGAAGGACGGCGTCAGACTGCAGACCAAGACCGGCGTGCTG

CACCTCCCACAGGCCGCTTGGTCCGACGCCGGAGTGTACACCTGTCAGGCCGAG

AACGGCGTGGGCAGCCTGGTGAGCCCCCCCATCAGCCTGCATATCTTCATGAGCG

GTGGTAGCGGAGGTAGTGGAGGTAGCACTACAACTCCAGCACCCAGACCCCCTA

CACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTTA CCTGTACGTGTTGAGCGGCATCGGCGGACTGCTGCTGCTGCTCCTGATCTTCATC

GTGCTGTACAAGGTGGGCTTTTTCAAAAGAAACCTGAAG SEQ ID NO: 675

[00716] Construct pJAQ304 [Siglec 2 Targeting Domain]-[CD8 trunc Hinge]- [CD162 TM]

ATGCACCTGCTTGGACCTTGGCTGCTGCTGCTGGTGCTGGAATACCTGGCCTTTA

GCGATAGCTCTAAATGGGTCTTTGAGCACCCTGAAACCCTGTATGCTTGGGAGGG

CGCCTGCGTGTGGATCCCCTGCACCTACAGGGCCCTGGACGGCGACCTGGAAAG

CTTCATTCTGTTCCACAACCCCGAGTACAACAAGAACACCAGCAAGTTCGACGGC

ACCAGACTGTACGAGTCTACAAAGGACGGCAAGGTGCCATCTGAGCAGAAAAGA

GTGCAGTTCCTGGGAGATAAGAACAAAAACTGCACCCTGAGCATCCACCCCGTG

CACCTGAATGATTCTGGCCAGCTGGGCCTGCGGATGGAATCCAAGACCGAGAAG

TGGATGGAAAGAATCCATCTGAACGTGTCCGAGAGACCTTTCCCCCTCCACATCC

AGCTGCCTCCAGAGATCCAGGAGAGCCAGGAGGTTACACTCACCTGTCTGCTGA

ACTTCTCATGCTACGGCTACCCTATCCAACTGCAATGGCTGCTGGAAGGCGTGCC

CATGCGGCAGGCCGCCGTGACTAGCACATCTCTGACCATCAAGTCCGTGTTTACA

CGCAGCGAGCTGAAGTTCAGCCCTCAGTGGAGCCACCACGGCAAGATCGTGACA

TGTCAGCTGCAGGACGCCGACGGCAAATTCCTGAGCAACGACACCGTGCAGCTG

AACGTGAAGCACACACCTAAGCTGGAAATCAAGGTGACCCCTAGCGACGCTATC

GTGCGGGAAGGCGACAGCGTGACAATGACCTGCGAGGTCAGCAGCAGCAATCCT

GAGTACACCACCGTGTCCTGGCTGAAAGATGGAACAAGCCTGAAGAAGCAGAAC

ACCTTCACCCTGAACCTGAGAGAGGTGACCAAGGATCAGAGCGGCAAGTACTGC

TGTCAGGTGTCTAATGACGTGGGACCTGGCAGAAGCGAGGAAGTGTTCCTTCAA

GTGCAGTACGCCACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTA

TCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTCTGCTGGCTATCCTGAT

CCTGGCCCTGGTCGCCACAATCTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAGA

CTGAGCAGAAAGGGCCACATGTACCCTGTGCGGAAC SEQ ID NO: 676 [00717] Construct pJAQ305 [Siglec 2 Targeting Domain]-[CD8 trunc Hinge]- [CD62L TM]

ATGCACCTGCTTGGACCTTGGCTGCTGCTGCTGGTGCTGGAATACCTGGCCTTTA

GCGATAGCTCTAAATGGGTCTTTGAGCACCCTGAAACCCTGTATGCTTGGGAGGG

CGCCTGCGTGTGGATCCCCTGCACCTACAGGGCCCTGGACGGCGACCTGGAAAG

CTTCATTCTGTTCCACAACCCCGAGTACAACAAGAACACCAGCAAGTTCGACGGC

ACCAGACTGTACGAGTCTACAAAGGACGGCAAGGTGCCATCTGAGCAGAAAAGA

GTGCAGTTCCTGGGAGATAAGAACAAAAACTGCACCCTGAGCATCCACCCCGTG

CACCTGAATGATTCTGGCCAGCTGGGCCTGCGGATGGAATCCAAGACCGAGAAG

TGGATGGAAAGAATCCATCTGAACGTGTCCGAGAGACCTTTCCCCCTCCACATCC

AGCTGCCTCCAGAGATCCAGGAGAGCCAGGAGGTTACACTCACCTGTCTGCTGA

ACTTCTCATGCTACGGCTACCCTATCCAACTGCAATGGCTGCTGGAAGGCGTGCC

CATGCGGCAGGCCGCCGTGACTAGCACATCTCTGACCATCAAGTCCGTGTTTACA

CGCAGCGAGCTGAAGTTCAGCCCTCAGTGGAGCCACCACGGCAAGATCGTGACA

TGTCAGCTGCAGGACGCCGACGGCAAATTCCTGAGCAACGACACCGTGCAGCTG

AACGTGAAGCACACACCTAAGCTGGAAATCAAGGTGACCCCTAGCGACGCTATC

GTGCGGGAAGGCGACAGCGTGACAATGACCTGCGAGGTCAGCAGCAGCAATCCT

GAGTACACCACCGTGTCCTGGCTGAAAGATGGAACAAGCCTGAAGAAGCAGAAC

ACCTTCACCCTGAACCTGAGAGAGGTGACCAAGGATCAGAGCGGCAAGTACTGC

TGTCAGGTGTCTAATGACGTGGGACCTGGCAGAAGCGAGGAAGTGTTCCTTCAA

GTGCAGTACGCCACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTA

TCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTCCTCTGTTCATCCCCGT

GGCCGTGATGGTGACCGCCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGA

AGACTGAAGAAGGGCAAGAAATCTAAGCGG SEQ ID NO: 677 [00718] Construct pJAQ306 [Siglec 2 Targeting Domain]-[CD8 trunc Hinge]-[HLA-

DRA TM]

ATGCACCTGCTTGGACCTTGGCTGCTGCTGCTGGTGCTGGAATACCTGGCCTTTA

GCGATAGCTCTAAATGGGTCTTTGAGCACCCTGAAACCCTGTATGCTTGGGAGGG

CGCCTGCGTGTGGATCCCCTGCACCTACAGGGCCCTGGACGGCGACCTGGAAAG

CTTCATTCTGTTCCACAACCCCGAGTACAACAAGAACACCAGCAAGTTCGACGGC

ACCAGACTGTACGAGTCTACAAAGGACGGCAAGGTGCCATCTGAGCAGAAAAGA

GTGCAGTTCCTGGGAGATAAGAACAAAAACTGCACCCTGAGCATCCACCCCGTG

CACCTGAATGATTCTGGCCAGCTGGGCCTGCGGATGGAATCCAAGACCGAGAAG

TGGATGGAAAGAATCCATCTGAACGTGTCCGAGAGACCTTTCCCCCTCCACATCC

AGCTGCCTCCAGAGATCCAGGAGAGCCAGGAGGTTACACTCACCTGTCTGCTGA

ACTTCTCATGCTACGGCTACCCTATCCAACTGCAATGGCTGCTGGAAGGCGTGCC

CATGCGGCAGGCCGCCGTGACTAGCACATCTCTGACCATCAAGTCCGTGTTTACA

CGCAGCGAGCTGAAGTTCAGCCCTCAGTGGAGCCACCACGGCAAGATCGTGACA

TGTCAGCTGCAGGACGCCGACGGCAAATTCCTGAGCAACGACACCGTGCAGCTG

AACGTGAAGCACACACCTAAGCTGGAAATCAAGGTGACCCCTAGCGACGCTATC

GTGCGGGAAGGCGACAGCGTGACAATGACCTGCGAGGTCAGCAGCAGCAATCCT

GAGTACACCACCGTGTCCTGGCTGAAAGATGGAACAAGCCTGAAGAAGCAGAAC

ACCTTCACCCTGAACCTGAGAGAGGTGACCAAGGATCAGAGCGGCAAGTACTGC

TGTCAGGTGTCTAATGACGTGGGACCTGGCAGAAGCGAGGAAGTGTTCCTTCAA

GTGCAGTACGCCACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTA

TCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTAACGTGGTGTGCGCCCT

GGGCCTGACCGTGAGCCTGGTCGGCATCATCATTGGAACAATCTTCATCATCAAG

GGCCTGAGAAAGAGCAACGCCGCTGAGCGGAGAGGCCCTCTG SEQ ID NO: 678

Construct pJAQ307 [Siglec 3 Targeting Domain]-[CD8 trunc Hinge]-[CD43 TM] [00719] Domain Name Domain Type Start End

ATGCCTCTGCTGCTCCTGCTGCCTCTCCTGTGGGCTGGCGCCCTGGCCATGGACC

CCAATTTCTGGCTGCAGGTGCAAGAGAGCGTCACCGTGCAGGAGGGCCTGTGCG

TGCTGGTGCCATGTACATTTTTCCACCCCATCCCCTACTACGACAAGAACAGCCC

TGTTCATGGCTACTGGTTCCGGGAAGGCGCTATCATCAGCAGAGATAGCCCCGTG

GCCACCAACAAGCTGGATCAGGAGGTGCAGGAGGAAACCCAGGGCAGATTCAG

ACTGCTGGGCGATCCTAGCCGGAACAACTGCAGCCTGAGCATCGTGGACGCCAG

AAGAAGGGACAACGGCTCTTATTTCTTTCGGATGGAACGGGGCAGCACCAAGTA

CAGCTACAAGTCCCCACAACTGAGCGTGCACGTGACAGACCTGACACACAGACC

TAAGATCCTGATCCCTGGAACCCTGGAACCCGGCCACTCTAAAAATCTGACCTGT

TCTGTCTCCTGGGCCTGCGAGCAGGGCACACCTCCTATCTTCAGCTGGCTGTCCG

CCGCCCCTACAAGCCTGGGACCTAGAACAACCCACAGCTCTGTGCTGATTATCAC

CCCTAGACCCCAGGACCACGGCACAAACCTGACCTGCCAGGTGAAATTCGCCGG

AGCCGGCGTGACCACCGAGAGAACCATCCAGCTGAACACTACAACTCCAGCACC

CAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCT

GAAGCCTGTGGCATGCTGCCTGTGGCTGTGCTGGTGGCCCTGCTCGCCGTGATCG

TGCTGGTCGCCCTGCTGCTGCTGTGGCGGAGAAGACAGAAGAGACGGACC

SEQ ID NO: 679

[00720] Construct pJAQ308 [Siglec 7 Targeting Domain]-[CD8 trunc Hinge]- [CD49d.2 TM]

ATGCTGCCGCTGCAGCTGCCGCCCCTGCTGTGGGGCAGAGAGAGAGTGGAAGGC

CAGAAAAGCAATAGAAAGGATTACAGCCTGACCATGCAGAGCAGCGTGACCGTG

CAGGAGGGCATGTGCGTGCACGTGCGGTGCAGCTTCAGCTACCCCGTGGATTCTC AGACCGACAGCGACCCCGTGCATGGCTACTGGTTCCGGGCCGGCAACGACATCT

CCTGGAAGGCCCCTGTGGCCACAAACAACCCTGCTTGGGCTGTGCAGGAGGAAA

CACGCGACAGATTCCACCTGCTGGGCGACCCTCAGACAAAGAACTGCACCCTGT

CCATCCGGGACGCCAGAATGAGCGATGCCGGAAGATACTTCTTCCGGATGGAAA

AAGGTAATATTAAGTGGAACTACAAGTACGACCAGCTGTCTGTTAACGTGACCG

CCCTGACCCACAGGCCTAACATCCTGATCCCCGGCACCCTGGAGTCTGGATGTTT

TCAGAATCTGACCTGCAGCGTCCCCTGGGCCTGTGAACAGGGCACCCCTCCAATG

ATCAGCTGGATGGGCACCAGCGTGTCCCCTCTGCACCCTAGCACCACCAGAAGCT

CCGTGCTGACCCTGATCCCTCAACCCCAACACCACGGCACAAGCCTGACATGCCA

GGTGACCCTGCCTGGCGCCGGCGTGACTACAAACAGAACAATCCAGCTGAACGT

TTCCTACCCTCCTCAAAACCTGACAGTGACCGTCTTTCAGGGCGAGGGCACAGCT

TCTACCGCCCTGGGAAACAGCAGCTCTCTGAGCGTGCTGGAAGGCCAGAGCCTG

AGACTGGTGTGCGCCGTGGACAGCAACCCACCTGCCAGACTGAGCTGGACCTGG

CGGAGCCTGACCCTTTATCCAAGCCAGCCTTCTAACCCCCTGGTGCTCGAGCTGC

AGGTCCACCTGGGAGATGAGGGCGAGTTCACCTGTAGAGCCCAGAATTCTCTGG

GCAGCCAGCACGTGTCCCTCAACCTGAGCTTGACTACAACTCCAGCACCCAGACC

CCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCC

TGTATCGTGATCATCTCTAGCAGCCTGCTGCTGGGCCTGATCGTGCTGCTGCTGA

TCAGCTACGTGATGTGGAAGGCCGGCCTCTTCAAAAAACAGTACAAGTCC

SEQ ID NO: 680

[00721] Construct pJAQ309 [Siglec 7 Targeting Domain]-[CD8 trunc Hinge]- [CD62L TM]

ATGCTGCCGCTGCAGCTGCCGCCCCTGCTGTGGGGCAGAGAGAGAGTGGAAGGC

CAGAAAAGCAATAGAAAGGATTACAGCCTGACCATGCAGAGCAGCGTGACCGTG

CAGGAGGGCATGTGCGTGCACGTGCGGTGCAGCTTCAGCTACCCCGTGGATTCTC

AGACCGACAGCGACCCCGTGCATGGCTACTGGTTCCGGGCCGGCAACGACATCT CCTGGAAGGCCCCTGTGGCCACAAACAACCCTGCTTGGGCTGTGCAGGAGGAAA

CACGCGACAGATTCCACCTGCTGGGCGACCCTCAGACAAAGAACTGCACCCTGT

CCATCCGGGACGCCAGAATGAGCGATGCCGGAAGATACTTCTTCCGGATGGAAA

AAGGTAATATTAAGTGGAACTACAAGTACGACCAGCTGTCTGTTAACGTGACCG

CCCTGACCCACAGGCCTAACATCCTGATCCCCGGCACCCTGGAGTCTGGATGTTT

TCAGAATCTGACCTGCAGCGTCCCCTGGGCCTGTGAACAGGGCACCCCTCCAATG

ATCAGCTGGATGGGCACCAGCGTGTCCCCTCTGCACCCTAGCACCACCAGAAGCT

CCGTGCTGACCCTGATCCCTCAACCCCAACACCACGGCACAAGCCTGACATGCCA

GGTGACCCTGCCTGGCGCCGGCGTGACTACAAACAGAACAATCCAGCTGAACGT

TTCCTACCCTCCTCAAAACCTGACAGTGACCGTCTTTCAGGGCGAGGGCACAGCT

TCTACCGCCCTGGGAAACAGCAGCTCTCTGAGCGTGCTGGAAGGCCAGAGCCTG

AGACTGGTGTGCGCCGTGGACAGCAACCCACCTGCCAGACTGAGCTGGACCTGG

CGGAGCCTGACCCTTTATCCAAGCCAGCCTTCTAACCCCCTGGTGCTCGAGCTGC

AGGTCCACCTGGGAGATGAGGGCGAGTTCACCTGTAGAGCCCAGAATTCTCTGG

GCAGCCAGCACGTGTCCCTCAACCTGAGCTTGACTACAACTCCAGCACCCAGACC

CCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCC

TGTCCTCTGTTCATCCCCGTGGCCGTGATGGTGACCGCCTTCAGCGGCCTGGCTTT

TATCATCTGGCTGGCCAGAAGACTGAAGAAGGGCAAGAAATCTAAGCGG

SEQ ID NO: 681

[00722] Construct pJAQ310 [Siglec 7 Targeting Domain]-[CD8 trunc Hinge]-[LFA- 1 TM]

ATGCTGCCGCTGCAGCTGCCGCCCCTGCTGTGGGGCAGAGAGAGAGTGGAAGGC

CAGAAAAGCAATAGAAAGGATTACAGCCTGACCATGCAGAGCAGCGTGACCGTG

CAGGAGGGCATGTGCGTGCACGTGCGGTGCAGCTTCAGCTACCCCGTGGATTCTC

AGACCGACAGCGACCCCGTGCATGGCTACTGGTTCCGGGCCGGCAACGACATCT

CCTGGAAGGCCCCTGTGGCCACAAACAACCCTGCTTGGGCTGTGCAGGAGGAAA CACGCGACAGATTCCACCTGCTGGGCGACCCTCAGACAAAGAACTGCACCCTGT

CCATCCGGGACGCCAGAATGAGCGATGCCGGAAGATACTTCTTCCGGATGGAAA

AAGGTAATATTAAGTGGAACTACAAGTACGACCAGCTGTCTGTTAACGTGACCG

CCCTGACCCACAGGCCTAACATCCTGATCCCCGGCACCCTGGAGTCTGGATGTTT

TCAGAATCTGACCTGCAGCGTCCCCTGGGCCTGTGAACAGGGCACCCCTCCAATG

ATCAGCTGGATGGGCACCAGCGTGTCCCCTCTGCACCCTAGCACCACCAGAAGCT

CCGTGCTGACCCTGATCCCTCAACCCCAACACCACGGCACAAGCCTGACATGCCA

GGTGACCCTGCCTGGCGCCGGCGTGACTACAAACAGAACAATCCAGCTGAACGT

TTCCTACCCTCCTCAAAACCTGACAGTGACCGTCTTTCAGGGCGAGGGCACAGCT

TCTACCGCCCTGGGAAACAGCAGCTCTCTGAGCGTGCTGGAAGGCCAGAGCCTG

AGACTGGTGTGCGCCGTGGACAGCAACCCACCTGCCAGACTGAGCTGGACCTGG

CGGAGCCTGACCCTTTATCCAAGCCAGCCTTCTAACCCCCTGGTGCTCGAGCTGC

AGGTCCACCTGGGAGATGAGGGCGAGTTCACCTGTAGAGCCCAGAATTCTCTGG

GCAGCCAGCACGTGTCCCTCAACCTGAGCTTGACTACAACTCCAGCACCCAGACC

CCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCC

TGTTACCTGTACGTGTTGAGCGGCATCGGCGGACTGCTGCTGCTGCTCCTGATCT

TCATCGTGCTGTACAAGGTGGGCTTTTTCAAAAGAAACCTGAAGSEQ ID NO: 682

[00723] Construct pJAQ311 [CD133 scFv 1 Targeting Domain]-[CD8 trunc Hinge]- [CD62L TM]

ATGGCCGAGGTGCAGCTGCTGGAAAGCGGCGGAGGCCTGGTGCAGCCTGGCGGC

AGCCTGAGACTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCTCCTACGCCATGA

GCTGGGTTAGACAGGCCCCTGGCAAGGGCCTCGAGTGGGTCAGCGCCATCAGCA

GAACCGGCGGCGTGACCAGATACGCCGACAGCGTGAAGGGCAGATTCACCATCA

GCCGGGACAACTCAAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGCCG

AGGATACAGCCGTGTACTACTGCGCCAAGCGGACCAGGCGGTTCGACTACTGGT

GCCAGGGCACCCTGGTGACAGTGTCCAGCAGCCCCAGCTCCCTGTCTGCTTCTGT GGGCGACAGAGTGACCATCACCTGCAGAGCCAGCCAGAGCATCAGCAGCTACCT

GAACTGGTACCAGCAGAAACCTGGAAAAGCCCCTAAGCTGCTGATCTACAGCGC

TTCTGATCTGCAATCCGGCGTGCCATCTAGATTTTCTGGCAGCGGATCTGGAACC

GATTTTACACTGACCATTTCCAGCCTGCAGCCCGAGGACTTCGCCACCTACTATT

GTCAGCAAACAGCTAATTCTCCTAGCACATTCGGCCAGGGAACAAAGGTGGAAA

TCACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCA

GCCCCTGTCACTGCGCCCTGAAGCCTGTCCTCTGTTCATCCCCGTGGCCGTGATG

GTGACCGCCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGAAGACTGAAGA

AGGGCAAGAAATCTAAGCGG SEQ ID NO: 683

[00724] Construct pJAQ312 [CD133 scFv 1 Targeting Domain]-[CD8 trunc Hinge]- [CD162 TM]

ATGGCCGAGGTGCAGCTGCTGGAAAGCGGCGGAGGCCTGGTGCAGCCTGGCGGC

AGCCTGAGACTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCTCCTACGCCATGA

GCTGGGTTAGACAGGCCCCTGGCAAGGGCCTCGAGTGGGTCAGCGCCATCAGCA

GAACCGGCGGCGTGACCAGATACGCCGACAGCGTGAAGGGCAGATTCACCATCA

GCCGGGACAACTCAAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGCCG

AGGATACAGCCGTGTACTACTGCGCCAAGCGGACCAGGCGGTTCGACTACTGGT

GCCAGGGCACCCTGGTGACAGTGTCCAGCAGCCCCAGCTCCCTGTCTGCTTCTGT

GGGCGACAGAGTGACCATCACCTGCAGAGCCAGCCAGAGCATCAGCAGCTACCT

GAACTGGTACCAGCAGAAACCTGGAAAAGCCCCTAAGCTGCTGATCTACAGCGC

TTCTGATCTGCAATCCGGCGTGCCATCTAGATTTTCTGGCAGCGGATCTGGAACC

GATTTTACACTGACCATTTCCAGCCTGCAGCCCGAGGACTTCGCCACCTACTATT

GTCAGCAAACAGCTAATTCTCCTAGCACATTCGGCCAGGGAACAAAGGTGGAAA

TCACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCA

GCCCCTGTCACTGCGCCCTGAAGCCTGTCTGCTGGCTATCCTGATCCTGGCCCTG GTCGCCACAATCTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAGACTGAGCAGAA

AGGGCCACATGTACCCTGTGCGGAACSEQ ID NO: 684

[00725] Construct pJAQ313 [CD133 scFv 1 Targeting Domain]-[CD8 trunc Hinge]- [ICAM1 TM]

ATGGCCGAGGTGCAGCTGCTGGAAAGCGGCGGAGGCCTGGTGCAGCCTGGCGGC

AGCCTGAGACTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCTCCTACGCCATGA

GCTGGGTTAGACAGGCCCCTGGCAAGGGCCTCGAGTGGGTCAGCGCCATCAGCA

GAACCGGCGGCGTGACCAGATACGCCGACAGCGTGAAGGGCAGATTCACCATCA

GCCGGGACAACTCAAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGCCG

AGGATACAGCCGTGTACTACTGCGCCAAGCGGACCAGGCGGTTCGACTACTGGT

GCCAGGGCACCCTGGTGACAGTGTCCAGCAGCCCCAGCTCCCTGTCTGCTTCTGT

GGGCGACAGAGTGACCATCACCTGCAGAGCCAGCCAGAGCATCAGCAGCTACCT

GAACTGGTACCAGCAGAAACCTGGAAAAGCCCCTAAGCTGCTGATCTACAGCGC

TTCTGATCTGCAATCCGGCGTGCCATCTAGATTTTCTGGCAGCGGATCTGGAACC

GATTTTACACTGACCATTTCCAGCCTGCAGCCCGAGGACTTCGCCACCTACTATT

GTCAGCAAACAGCTAATTCTCCTAGCACATTCGGCCAGGGAACAAAGGTGGAAA

TCACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCA

GCCCCTGTCACTGCGCCCTGAAGCCTGTATCGTGATCATCACCGTGGTCGCCGCC

GCTGTGATCATGGGCACAGCCGGCCTGAGCACCTACCTGTACAACAGACAGAGA

AAGATCAAGAAATACCGGCTG SEQ ID NO: 685

[00726] Construct pJAQ314 [CD133 scFv 2 Targeting Domain]-[CD8 trunc Hinge]- [CD162 TM]

ATGGACATCGTGCTGAGCCAGAGCCCAGCTATCATGAGCGCCAGCCCTGGCGAG

AAGGTGACCATCAGCTGCAGCGCTAGCTCCAGCGTGTCTTACATGTACTGGTACC

AGCAAAAGCCCGGCTCTTCTCCAAAGCCCTGGATCTACCGGACCTCTAATCTGGC

CTCTGGCGTGCCCGCCAGATTTTCTGGCAGCGGCAGCGGAACCAGCTACAGCCTG

ACAATCAGCAGCATGGAAGCCGAGGATGCCGCTACCTACTACTGCCAGCAGTAC

CACAGCTACCCTCCTACCTTCGGCGCCGGCACAAAGCTGGAACTGAAAAGCTCC

GGCGGTGGAGGCAGCGGAGGCGGCGGCGGCGGAAGCTCTAGAAGCAGCCTGGA

AGTGAAACTGGTGGAAAGCGGCCCTGAGCTGAAGAAGCCTGGAGAAACCGTGA

AGATCTCCTGTAAAGCCAGCGGCTATACATTTACCGATTACAGCATGAAGTGGGT

CAACCAGGCCCCTGGCAAGGGCCTGAAGTGGATGGGCTGGATTAACACCGAGAC

CGGCGAGCCTAGCTACGCCGACGACTTCAAGGGCAGATTCGCCTTCAGCCTCGA

GACATCTGCTAGCACCGCCTACCTGCAGATCAACAACCTGAAGAACGAGGACAC

CGCCACATACTTCTGCGCCACCGACTATGGCGATTACTTCGACTACTGGGGCCAG

GGAACAACACTGACCGTGTCCTCCACTACAACTCCAGCACCCAGACCCCCTACAC

CTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTCTGCT

GGCTATCCTGATCCTGGCCCTGGTCGCCACAATCTTCTTCGTGTGCACCGTGGTG

CTGGCCGTGAGACTGAGCAGAAAGGGCCACATGTACCCTGTGCGGAAC

SEQ ID NO: 686

[00727] Construct pJAQ315 [CD133 scFv 2 Targeting Domain]-[CD8 trunc Hinge]- [ICAM1 TM]

ATGGACATCGTGCTGAGCCAGAGCCCAGCTATCATGAGCGCCAGCCCTGGCGAG

AAGGTGACCATCAGCTGCAGCGCTAGCTCCAGCGTGTCTTACATGTACTGGTACC

AGCAAAAGCCCGGCTCTTCTCCAAAGCCCTGGATCTACCGGACCTCTAATCTGGC CTCTGGCGTGCCCGCCAGATTTTCTGGCAGCGGCAGCGGAACCAGCTACAGCCTG

ACAATCAGCAGCATGGAAGCCGAGGATGCCGCTACCTACTACTGCCAGCAGTAC

CACAGCTACCCTCCTACCTTCGGCGCCGGCACAAAGCTGGAACTGAAAAGCTCC

GGCGGTGGAGGCAGCGGAGGCGGCGGCGGCGGAAGCTCTAGAAGCAGCCTGGA

AGTGAAACTGGTGGAAAGCGGCCCTGAGCTGAAGAAGCCTGGAGAAACCGTGA

AGATCTCCTGTAAAGCCAGCGGCTATACATTTACCGATTACAGCATGAAGTGGGT

CAACCAGGCCCCTGGCAAGGGCCTGAAGTGGATGGGCTGGATTAACACCGAGAC

CGGCGAGCCTAGCTACGCCGACGACTTCAAGGGCAGATTCGCCTTCAGCCTCGA

GACATCTGCTAGCACCGCCTACCTGCAGATCAACAACCTGAAGAACGAGGACAC

CGCCACATACTTCTGCGCCACCGACTATGGCGATTACTTCGACTACTGGGGCCAG

GGAACAACACTGACCGTGTCCTCCACTACAACTCCAGCACCCAGACCCCCTACAC

CTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATCGT

GATCATCACCGTGGTCGCCGCCGCTGTGATCATGGGCACAGCCGGCCTGAGCAC

CTACCTGTACAACAGACAGAGAAAGATCAAGAAATACCGGCTG SEQ ID NO: 687

[00728] Construct pJAQ316 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]- [CD8 trunc Hinge] -[CD49d.2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

ACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGC

CCCTGTCACTGCGCCCTGAAGCCTGTATCGTGATCATCTCTAGCAGCCTGCTGCT GGGCCTGATCGTGCTGCTGCTGATCAGCTACGTGATGTGGAAGGCCGGCCTCTTC

AAAAAACAGTACAAGTCC SEQ ID NO: 688

[00729] Construct pJAQ317 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]- [CD8 trunc Hinge] -[CD 162 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

ACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGC

CCCTGTCACTGCGCCCTGAAGCCTGTCTGCTGGCTATCCTGATCCTGGCCCTGGTC

GCCACAATCTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAGACTGAGCAGAAAG

GGCCACATGTACCCTGTGCGGAAC SEQ ID NO: 689

[00730] Construct pJAQ318 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]-

[CD8 trunc Hinge] -[ICAM1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

ACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGC

CCCTGTCACTGCGCCCTGAAGCCTGTATCGTGATCATCACCGTGGTCGCCGCCGC

TGTGATCATGGGCACAGCCGGCCTGAGCACCTACCTGTACAACAGACAGAGAAA

GATCAAGAAATACCGGCTG SEQ ID NO: 690

[00731] Construct pJAQ319 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain]-[CD8 trunc Hinge]-[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC

CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT

CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG

ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC

TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC

CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC

TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCACTACAACTCCAGCACCCAGACCCCCTA

CACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTCC

TCTGTTCATCCCCGTGGCCGTGATGGTGACCGCCTTCAGCGGCCTGGCTTTTATCA

TCTGGCTGGCCAGAAGACTGAAGAAGGGCAAGAAATCTAAGCGG SEQ ID

NO: 691

[00732] Construct pJAQ320 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC

CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG

AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT

CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG

ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC

TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC

CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC

TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCACTACAACTCCAGCACCCAGACCCCCTA

CACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTAT

CGTGATCATCACCGTGGTCGCCGCCGCTGTGATCATGGGCACAGCCGGCCTGAGC

ACCTACCTGTACAACAGACAGAGAAAGATCAAGAAATACCGGCTG SEQ ID NO: 692

[00733] Construct pJAQ321 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain]-[CD8 trunc Hinge]-[LFA-1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC

CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG

AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT

CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG

ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC

TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC

CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC

TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCACTACAACTCCAGCACCCAGACCCCCTA

CACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTTA

CCTGTACGTGTTGAGCGGCATCGGCGGACTGCTGCTGCTGCTCCTGATCTTCATC

GTGCTGTACAAGGTGGGCTTTTTCAAAAGAAACCTGAAG SEQ ID NO: 693

[00734] Construct pJAQ322 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [CD8 trunc Hinge] -[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGC

AAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTCCTCTGTTCATCCCCGTGGCC

GTGATGGTGACCGCCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGAAGAC

TGAAGAAGGGCAAGAAATCTAAGCGG SEQ ID NO: 694

[00735] Construct pJAQ323 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [CD8 trunc Hinge] -[ICAM1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGC

AAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATCGTGATCATCACCGTGGTC

GCCGCCGCTGTGATCATGGGCACAGCCGGCCTGAGCACCTACCTGTACAACAGA

CAGAGAAAGATCAAGAAATACCGGCTG SEQ ID NO: 695

[00736] Construct pJAQ324 [CD8a Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain] -[CD 8 trunc Hinge] -[CD 162 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTA

CGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCT

AATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTC

TCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGG

ACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCA

AGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAAC

AACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATC

TGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATT

GCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGG TTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATAC

AGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTC

GACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAA

AACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATG

CCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTAC

ATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGA

ACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCA

TCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCA

CACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACACTAC

AACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTG

TCACTGCGCCCTGAAGCCTGTCTGCTGGCTATCCTGATCCTGGCCCTGGTCGCCA

CAATCTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAGACTGAGCAGAAAGGGCC

ACATGTACCCTGTGCGGAAC SEQ ID NO: 696

[00737] Construct pJAQ325 [CD8a Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain]-[CD8 trunc Hinge]-[LFA-1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTA

CGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCT

AATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTC

TCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGG

ACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCA

AGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAAC

AACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATC

TGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATT GCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGG

TTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATAC

AGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTC

GACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAA

AACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATG

CCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTAC

ATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGA

ACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCA

TCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCA

CACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACACTAC

AACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTG

TCACTGCGCCCTGAAGCCTGTTACCTGTACGTGTTGAGCGGCATCGGCGGACTGC

TGCTGCTGCTCCTGATCTTCATCGTGCTGTACAAGGTGGGCTTTTTCAAAAGAAA

CCTGAAG SEQ ID NO: 697

[00738] Construct pJAQ326 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]-

[CD8 trunc Hinge] -[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

ACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGC

CCCTGTCACTGCGCCCTGAAGCCTGTCCTCTGTTCATCCCCGTGGCCGTGATGGT GACCGCCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGAAGACTGAAGAAG

GGCAAGAAATCTAAGCGG SEQ ID NO: 698

[00739] Construct pJAQ327 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]- [CD8 trunc Hinge] -[HLA-A2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

ACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGC

CCCTGTCACTGCGCCCTGAAGCCTGTATCGTGGGCATCATCGCCGGACTGGTGCT

GTTCGGCGCCGTCATCACCGGCGCTGTGGTGGCCGCCGTGATGTGGCGGAGAAA

GTCTAGCGACAGAAAGGGC SEQ ID NO: 699

[00740] Construct pJAQ328 [CD90 scFvl Targeting Domain]-[CD8 trunc Hinge]-

[HLA-DRA TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT

ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG

GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA

TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA

GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT

ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC

TAAATTGGAGTTGAAGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCA

ACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTAACGTGGTGTGCG

CCCTGGGCCTGACCGTGAGCCTGGTCGGCATCATCATTGGAACAATCTTCATCAT

CAAGGGCCTGAGAAAGAGCAACGCCGCTGAGCGGAGAGGCCCTCTG SEQ ID NO: 700

[00741] Construct pJAQ329 [CD90 scFvl Targeting Domain]-[CD8 trunc Hinge]- [ICAM1 TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT

GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT

ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG

GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA

GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT

ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC

TAAATTGGAGTTGAAGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCA

ACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATCGTGATCATCA

CCGTGGTCGCCGCCGCTGTGATCATGGGCACAGCCGGCCTGAGCACCTACCTGTA

CAACAGACAGAGAAAGATCAAGAAATACCGGCTGSEQ ID NO: 701

[00742] Construct pJAQ330 [CD133 scFv 1 Targeting Domain]-[CD8 trunc Hinge]- [CD43 TM]

ATGGCCGAGGTGCAGCTGCTGGAAAGCGGCGGAGGCCTGGTGCAGCCTGGCGGC

AGCCTGAGACTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCTCCTACGCCATGA

GCTGGGTTAGACAGGCCCCTGGCAAGGGCCTCGAGTGGGTCAGCGCCATCAGCA

GAACCGGCGGCGTGACCAGATACGCCGACAGCGTGAAGGGCAGATTCACCATCA

GCCGGGACAACTCAAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGCCG

AGGATACAGCCGTGTACTACTGCGCCAAGCGGACCAGGCGGTTCGACTACTGGT

GCCAGGGCACCCTGGTGACAGTGTCCAGCAGCCCCAGCTCCCTGTCTGCTTCTGT

GGGCGACAGAGTGACCATCACCTGCAGAGCCAGCCAGAGCATCAGCAGCTACCT

GAACTGGTACCAGCAGAAACCTGGAAAAGCCCCTAAGCTGCTGATCTACAGCGC

TTCTGATCTGCAATCCGGCGTGCCATCTAGATTTTCTGGCAGCGGATCTGGAACC

GATTTTACACTGACCATTTCCAGCCTGCAGCCCGAGGACTTCGCCACCTACTATT

GTCAGCAAACAGCTAATTCTCCTAGCACATTCGGCCAGGGAACAAAGGTGGAAA

TCACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCA

GCCCCTGTCACTGCGCCCTGAAGCCTGTGGCATGCTGCCTGTGGCTGTGCTGGTG GCCCTGCTCGCCGTGATCGTGCTGGTCGCCCTGCTGCTGCTGTGGCGGAGAAGAC

AGAAGAGACGGACC SEQ ID NO: 702

[00743] Construct pJAQ331 [CD133 scFv 1 Targeting Domain]-[CD8 trunc Hinge]- [HLA-A2 TM]

ATGGCCGAGGTGCAGCTGCTGGAAAGCGGCGGAGGCCTGGTGCAGCCTGGCGGC

AGCCTGAGACTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCTCCTACGCCATGA

GCTGGGTTAGACAGGCCCCTGGCAAGGGCCTCGAGTGGGTCAGCGCCATCAGCA

GAACCGGCGGCGTGACCAGATACGCCGACAGCGTGAAGGGCAGATTCACCATCA

GCCGGGACAACTCAAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGCCG

AGGATACAGCCGTGTACTACTGCGCCAAGCGGACCAGGCGGTTCGACTACTGGT

GCCAGGGCACCCTGGTGACAGTGTCCAGCAGCCCCAGCTCCCTGTCTGCTTCTGT

GGGCGACAGAGTGACCATCACCTGCAGAGCCAGCCAGAGCATCAGCAGCTACCT

GAACTGGTACCAGCAGAAACCTGGAAAAGCCCCTAAGCTGCTGATCTACAGCGC

TTCTGATCTGCAATCCGGCGTGCCATCTAGATTTTCTGGCAGCGGATCTGGAACC

GATTTTACACTGACCATTTCCAGCCTGCAGCCCGAGGACTTCGCCACCTACTATT

GTCAGCAAACAGCTAATTCTCCTAGCACATTCGGCCAGGGAACAAAGGTGGAAA

TCACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCA

GCCCCTGTCACTGCGCCCTGAAGCCTGTATCGTGGGCATCATCGCCGGACTGGTG

CTGTTCGGCGCCGTCATCACCGGCGCTGTGGTGGCCGCCGTGATGTGGCGGAGA

AAGTCTAGCGACAGAAAGGGC SEQ ID NO: 703

[00744] Construct pJAQ332 [CD133 scFv 2 Targeting Domain]-[CD8 trunc Hinge]- [CD62L TM]

ATGGACATCGTGCTGAGCCAGAGCCCAGCTATCATGAGCGCCAGCCCTGGCGAG

AAGGTGACCATCAGCTGCAGCGCTAGCTCCAGCGTGTCTTACATGTACTGGTACC

AGCAAAAGCCCGGCTCTTCTCCAAAGCCCTGGATCTACCGGACCTCTAATCTGGC

CTCTGGCGTGCCCGCCAGATTTTCTGGCAGCGGCAGCGGAACCAGCTACAGCCTG

ACAATCAGCAGCATGGAAGCCGAGGATGCCGCTACCTACTACTGCCAGCAGTAC

CACAGCTACCCTCCTACCTTCGGCGCCGGCACAAAGCTGGAACTGAAAAGCTCC

GGCGGTGGAGGCAGCGGAGGCGGCGGCGGCGGAAGCTCTAGAAGCAGCCTGGA

AGTGAAACTGGTGGAAAGCGGCCCTGAGCTGAAGAAGCCTGGAGAAACCGTGA

AGATCTCCTGTAAAGCCAGCGGCTATACATTTACCGATTACAGCATGAAGTGGGT

CAACCAGGCCCCTGGCAAGGGCCTGAAGTGGATGGGCTGGATTAACACCGAGAC

CGGCGAGCCTAGCTACGCCGACGACTTCAAGGGCAGATTCGCCTTCAGCCTCGA

GACATCTGCTAGCACCGCCTACCTGCAGATCAACAACCTGAAGAACGAGGACAC

CGCCACATACTTCTGCGCCACCGACTATGGCGATTACTTCGACTACTGGGGCCAG

GGAACAACACTGACCGTGTCCTCCACTACAACTCCAGCACCCAGACCCCCTACAC

CTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTCCTCT

GTTCATCCCCGTGGCCGTGATGGTGACCGCCTTCAGCGGCCTGGCTTTTATCATCT

GGCTGGCCAGAAGACTGAAGAAGGGCAAGAAATCTAAGCGG SEQ ID NO: 704

[00745] Construct pJAQ333 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]-

[CD8 trunc Hinge] -[HLA-DRA TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

ACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGC

CCCTGTCACTGCGCCCTGAAGCCTGTAACGTGGTGTGCGCCCTGGGCCTGACCGT

GAGCCTGGTCGGCATCATCATTGGAACAATCTTCATCATCAAGGGCCTGAGAAA

GAGCAACGCCGCTGAGCGGAGAGGCCCTCTG SEQ ID NO: 705

[00746] Construct pJAQ334 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain] -[CD 8 trunc Hinge] -[CD 162 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC

CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG

AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT

CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG

ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC

CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC

TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCACTACAACTCCAGCACCCAGACCCCCTA

CACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTCT

GCTGGCTATCCTGATCCTGGCCCTGGTCGCCACAATCTTCTTCGTGTGCACCGTG

GTGCTGGCCGTGAGACTGAGCAGAAAGGGCCACATGTACCCTGTGCGGAAC

SEQ ID NO: 706

[00747] Construct pJAQ335 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [CD8 trunc Hinge] -[CD43 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGC

AAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTGGCATGCTGCCTGTGGCTGTG

CTGGTGGCCCTGCTCGCCGTGATCGTGCTGGTCGCCCTGCTGCTGCTGTGGCGGA

GAAGACAGAAGAGACGGACC SEQ ID NO: 707

[00748] Construct pJAQ336 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [CD8 trunc Hinge] -[HLA-A2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC AGGAGGTGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGC

AAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATCGTGGGCATCATCGCCGGA

CTGGTGCTGTTCGGCGCCGTCATCACCGGCGCTGTGGTGGCCGCCGTGATGTGGC

GGAGAAAGTCTAGCGACAGAAAGGGC SEQ ID NO: 708

[00749] Construct pJAQ337 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [CD8 trunc Hinge] -[HLA-DRA TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGC

AAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTAACGTGGTGTGCGCCCTGGGC CTGACCGTGAGCCTGGTCGGCATCATCATTGGAACAATCTTCATCATCAAGGGCC

TGAGAAAGAGCAACGCCGCTGAGCGGAGAGGCCCTCTG SEQ ID NO: 709

[00750] Construct pJAQ338 [CD8a Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain]-[CD8 trunc Hinge] -[CD49d.2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTA

CGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCT

AATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTC

TCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGG

ACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCA

AGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAAC

AACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATC

TGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATT

GCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGG

TTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATAC

AGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTC

GACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAA

AACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATG

CCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTAC

ATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGA

ACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCA

TCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCA

CACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACACTAC

AACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTG TCACTGCGCCCTGAAGCCTGTATCGTGATCATCTCTAGCAGCCTGCTGCTGGGCC

TGATCGTGCTGCTGCTGATCAGCTACGTGATGTGGAAGGCCGGCCTCTTCAAAAA

ACAGTACAAGTCCSEQ ID NO: 710

[00751] Construct pJAQ339 [CD8a Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain]-[CD8 trunc Hinge]-[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTA

CGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCT

AATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTC

TCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGG

ACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCA

AGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAAC

AACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATC

TGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATT

GCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGG

TTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATAC

AGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTC

GACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAA

AACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATG

CCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTAC

ATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGA

ACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCA

TCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCA

CACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACACTAC AACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTG

TCACTGCGCCCTGAAGCCTGTCCTCTGTTCATCCCCGTGGCCGTGATGGTGACCG

CCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGAAGACTGAAGAAGGGCA

AGAAATCTAAGCGG SEQ ID NO: 711

[00752] Construct pJAQ340 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]- [CD8 trunc Hinge] -[CD49d.2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

ACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGC

CCCTGTCACTGCGCCCTGAAGCCTGTATCGTGATCATCTCTAGCAGCCTGCTGCT

GGGCCTGATCGTGCTGCTGCTGATCAGCTACGTGATGTGGAAGGCCGGCCTCTTC

AAAAAACAGTACAAGTCC SEQ ID NO: 712

[00753] Construct pJAQ341 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]-

[CD8 trunc Hinge] -[CD 162 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

ACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGC

CCCTGTCACTGCGCCCTGAAGCCTGTCTGCTGGCTATCCTGATCCTGGCCCTGGTC

GCCACAATCTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAGACTGAGCAGAAAG

GGCCACATGTACCCTGTGCGGAAC SEQ ID NO: 713

[00754] Construct pJAQ342 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]-

[CD8 trunc Hinge] -[LFA-1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

ACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGC

CCCTGTCACTGCGCCCTGAAGCCTGTTACCTGTACGTGTTGAGCGGCATCGGCGG

ACTGCTGCTGCTGCTCCTGATCTTCATCGTGCTGTACAAGGTGGGCTTTTTCAAAA

GAAACCTGAAG SEQ ID NO: 714 [00755] Construct pJAQ343 [B2M Signal Peptide]-[SCF full Targeting Domain]- [CD8 trunc Hinge] -[CD43 TM]

ATGAGCAGAAGCGTGGCCCTGGCCGTGCTGGCTCTGCTGTCTCTGTCCGGCCTGG

AGGCCAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCT

GTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAA

CGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCAC

CCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGA

GATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAA

CATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTG

GACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCT

TTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCA

ACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTG

CGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAA

GCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGC

TCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCT

ATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTA

TTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAA

CGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGG

AGGTGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAG

TCAGCCCCTGTCACTGCGCCCTGAAGCCTGTGGCATGCTGCCTGTGGCTGTGCTG

GTGGCCCTGCTCGCCGTGATCGTGCTGGTCGCCCTGCTGCTGCTGTGGCGGAGAA

GACAGAAGAGACGGACC SEQ ID NO: 715

[00756] Construct pJAQ344 [B2M Signal Peptide]-[SCF full Targeting Domain]-

[CD8 trunc Hinge] -[HLA-A2 TM]

ATGAGCAGAAGCGTGGCCCTGGCCGTGCTGGCTCTGCTGTCTCTGTCCGGCCTGG

AGGCCAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCT

GTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAA

CGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCAC

CCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGA

GATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAA

CATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTG

GACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCT

TTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCA

ACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTG

CGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAA

GCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGC

TCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCT

ATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTA

TTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAA

CGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGG

AGGTGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAG

TCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATCGTGGGCATCATCGCCGGACTG

GTGCTGTTCGGCGCCGTCATCACCGGCGCTGTGGTGGCCGCCGTGATGTGGCGGA

GAAAGTCTAGCGACAGAAAGGGC SEQ ID NO: 716

[00757] Construct pJAQ345 [CD90 scFvl Targeting Domain]-[CD8 trunc Hinge]-

[CD62L TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT

GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT

ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG

GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA

TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA

GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT

ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC

TAAATTGGAGTTGAAGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCA

ACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTCCTCTGTTCATCC

CCGTGGCCGTGATGGTGACCGCCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGC

CAGAAGACTGAAGAAGGGCAAGAAATCTAAGCGGSEQ ID NO: 717

[00758] Construct pJAQ346 [CD90 scFvl Targeting Domain]-[CD8 trunc Hinge]- [CD162 TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT

GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG

GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA

TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA

GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT

ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC

TAAATTGGAGTTGAAGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCA

ACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTCTGCTGGCTATCC

TGATCCTGGCCCTGGTCGCCACAATCTTCTTCGTGTGCACCGTGGTGCTGGCCGT

GAGACTGAGCAGAAAGGGCCACATGTACCCTGTGCGGAAC SEQ ID NO: 718

[00759] Construct pJAQ347 [CD90 scFvl Targeting Domain]-[CD8 trunc Hinge]-

[LFA-1 TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT

GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT

ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG

GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA

TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA

GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT

ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC TAAATTGGAGTTGAAGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCA

ACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTTACCTGTACGTGT

TGAGCGGCATCGGCGGACTGCTGCTGCTGCTCCTGATCTTCATCGTGCTGTACAA

GGTGGGCTTTTTCAAAAGAAACCTGAAG SEQ ID NO: 719

[00760] Construct pJAQ358 [CD8a Signal Peptide]-[TPO-157 Targeting Domain]- [CD8 trunc Hinge] -[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTGACCGAGCTGCTGCTGGTCGTGATGCTGCTGCTCACCGCCAG

ACTGACCCTGAGCAGCCCCGCCCCTCCTGCCTGCGATCTGCGGGTGCTGTCTAAA

CTGCTGCGGGACAGCCACGTGCTGCATTCTAGACTGAGCCAGTGTCCTGAGGTGC

ACCCCCTGCCCACCCCTGTGCTGCTGCCCGCTGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAAATGGAAGAGACAAAGGCCCAAGACATCCTGGGCGCCGTGACCCT

GCTGCTGGAAGGCGTGATGGCCGCTAGAGGCCAGCTGGGCCCTACATGCCTGTC

CAGCCTCCTGGGACAGCTGTCCGGCCAGGTGCGGCTGCTGCTTGGAGCCCTGCAG

AGCCTGCTGGGCACACAGCTGCCACCTCAGGGCAGAACCACAGCCCACAAGGAT

CCTAACGCCATCTTCCTGAGCTTTCAGCACCTGCTGAGAACTACAACTCCAGCAC

CCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCC

TGAAGCCTGTCCTCTGTTCATCCCCGTGGCCGTGATGGTGACCGCCTTCAGCGGC

CTGGCTTTTATCATCTGGCTGGCCAGAAGACTGAAGAAGGGCAAGAAATCTAAG

CGG SEQ ID NO: 720

[00761] Construct pJAQ359 [CD8a Signal Peptide]-[TPO-157 Targeting Domain]-

[CD8 trunc Hinge] -[LFA-1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTGACCGAGCTGCTGCTGGTCGTGATGCTGCTGCTCACCGCCAG

ACTGACCCTGAGCAGCCCCGCCCCTCCTGCCTGCGATCTGCGGGTGCTGTCTAAA

CTGCTGCGGGACAGCCACGTGCTGCATTCTAGACTGAGCCAGTGTCCTGAGGTGC

ACCCCCTGCCCACCCCTGTGCTGCTGCCCGCTGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAAATGGAAGAGACAAAGGCCCAAGACATCCTGGGCGCCGTGACCCT

GCTGCTGGAAGGCGTGATGGCCGCTAGAGGCCAGCTGGGCCCTACATGCCTGTC

CAGCCTCCTGGGACAGCTGTCCGGCCAGGTGCGGCTGCTGCTTGGAGCCCTGCAG

AGCCTGCTGGGCACACAGCTGCCACCTCAGGGCAGAACCACAGCCCACAAGGAT

CCTAACGCCATCTTCCTGAGCTTTCAGCACCTGCTGAGAACTACAACTCCAGCAC

CCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCC

TGAAGCCTGTTACCTGTACGTGTTGAGCGGCATCGGCGGACTGCTGCTGCTGCTC

CTGATCTTCATCGTGCTGTACAAGGTGGGCTTTTTCAAAAGAAACCTGAAG

SEQ ID NO: 721

[00762] Construct pJAQ360 [CD8a Signal Peptide] -[CALR-ins5 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTATGCTGCTTAGCGTGCCTCTGCTGCTGGGCCTGCTGGGCCTGGCCGT

GGCCGAACCCGCCGTGTACTTCAAGGAACAGTTCCTCGACGGCGATGGATGGAC

ATCTAGATGGATCGAGTCTAAGCATAAGAGCGATTTCGGCAAGTTTGTGCTGAGC TCCGGCAAGTTCTACGGCGACGAGGAAAAAGATAAGGGCCTGCAGACCAGCCAA

GACGCCAGATTCTACGCTCTGAGCGCCAGCTTCGAGCCCTTCTCCAACAAGGGCC

AGACCCTGGTCGTGCAGTTTACAGTGAAGCACGAGCAGAACATCGATTGCGGCG

GAGGCTACGTGAAGCTGTTCCCCAACTCTCTGGATCAGACAGATATGCACGGCG

ACAGCGAGTACAACATCATGTTCGGCCCTGACATCTGTGGCCCCGGCACAAAGA

AAGTGCACGTGATCTTTAACTACAAAGGAAAAAACGTGCTGATCAACAAAGACA

TCAGATGCAAGGACGACGAGTTCACCCACCTGTACACCCTGATTGTGCGGCCTGA

TAATACCTACGAGGTGAAGATCGATAACAGCCAGGTCGAGAGCGGCAGCCTGGA

AGACGACTGGGATTTCCTGCCTCCTAAGAAGATCAAGGACCCCGATGCTAGCAA

GCCCGAGGACTGGGACGAGAGAGCCAAGATTGACGACCCTACAGACTCCAAGCC

TGAGGACTGGGACAAGCCCGAGCACATCCCTGATCCTGATGCTAAAAAGCCTGA

GGACTGGGACGAGGAAATGGACGGCGAATGGGAGCCTCCAGTGATCCAGAATCC

TGAATACAAGGGCGAATGGAAGCCTAGGCAGATCGACAACCCAGACTACAAGG

GCACCTGGATCCACCCTGAGATCGACAATCCTGAGTATTCTCCCGACCCCAGCAT

CTACGCCTATGATAACTTTGGAGTTCTGGGACTGGACCTGTGGCAGGTGAAGTCT

GGAACCATCTTCGACAACTTCCTGATCACTAACGACGAGGCCTACGCCGAGGAA

TTCGGCAACGAGACCTGGGGCGTGACCAAGGCCGCCGAGAAACAGATGAAAGA

CAAGCAGGACGAAGAACAGCGGCTGAAGGAAGAAGAGGAAGATAAGAAAAGA

AAGGAAGAAGAGGAGGCTGAGGATAATTGTAGACGGATGATGAGAACCAAGAT

GCGCATGCGGAGAATGAGAAGAACCAGAAGAAAGATGCGGCGGAAGATGAGCC

CTGCCAGACCGCGGACAAGCTGCCGGGAAGCCTGCCTGCAAGGCTGGACCGAGG

CCACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCA

GCCCCTGTCACTGCGCCCTGAAGCCTGTATTGTCATCATCACCGTGGTGGCGGCT

GCCGTGATCATGGGCACCGCCGGTCTCTCCACTTATCTGTACAACCGCCAGCGTA

AAATCAAGAAGTACCGCCTG SEQ ID NO: 722

[00763] Construct pJAQ361 [CD8a Signal Peptide]-[CALR-del52 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTATGCTGCTGTCCGTGCCTCTGCTGCTGGGCCTGCTGGGACTGGCCGT

GGCCGAGCCAGCCGTTTACTTCAAGGAACAGTTTCTGGACGGCGACGGCTGGAC

AAGCAGATGGATCGAGTCTAAGCATAAGTCCGACTTCGGCAAGTTCGTGCTGTCT

AGCGGAAAATTCTACGGCGATGAAGAGAAGGACAAGGGCCTGCAGACCTCCCA

GGACGCTAGATTCTACGCCCTGAGCGCCTCTTTCGAACCCTTCAGCAACAAGGGA

CAGACCCTGGTGGTGCAATTCACCGTGAAACACGAGCAGAATATCGACTGCGGT

GGCGGCTACGTCAAGCTGTTCCCCAACAGCCTGGACCAGACAGACATGCACGGC

GACAGCGAGTACAACATCATGTTCGGCCCTGATATCTGCGGCCCCGGCACAAAG

AAGGTGCACGTGATCTTTAACTACAAGGGCAAGAACGTGCTGATTAACAAAGAC

ATCCGGTGCAAGGACGACGAGTTCACACACCTGTACACCCTGATCGTGCGGCCT

GACAACACCTACGAGGTGAAGATCGACAATTCTCAGGTCGAGAGCGGCAGCCTC

GAGGACGATTGGGATTTCCTTCCTCCTAAGAAAATCAAAGACCCCGATGCCAGC

AAACCTGAAGACTGGGATGAGAGAGCCAAGATCGACGACCCCACCGACAGCAA

GCCTGAAGATTGGGACAAACCTGAGCACATCCCTGACCCCGATGCCAAAAAGCC

TGAGGATTGGGATGAAGAGATGGACGGAGAATGGGAGCCTCCAGTGATTCAGAA

CCCTGAATATAAGGGCGAGTGGAAGCCTAGACAGATCGATAATCCTGATTACAA

GGGCACCTGGATCCACCCTGAAATCGACAATCCCGAGTATAGCCCAGACCCAAG

CATCTACGCCTACGACAACTTTGGAGTGCTGGGCCTGGATCTGTGGCAGGTGAAG

TCTGGCACCATCTTTGACAACTTCCTGATCACCAACGACGAGGCTTACGCTGAGG

AATTCGGCAACGAGACATGGGGGGTGACCAAGGCCGCTGAAAAGCAGATGAAA

GACAAGCAAGACGAAGAACAAAGAACCAGACGCATGATGCGGACAAAGATGCG

GATGCGGCGGATGAGAAGAACAAGAAGGAAGATGAGACGGAAGATGAGCCCTG

CCAGACCCAGAACCAGCTGCAGAGAGGCCTGTCTGCAGGGCTGGACCGAGGCCA

CTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCC

CCTGTCACTGCGCCCTGAAGCCTGTATTGTCATCATCACCGTGGTGGCGGCTGCC

GTGATCATGGGCACCGCCGGTCTCTCCACTTATCTGTACAACCGCCAGCGTAAAA

TCAAGAAGTACCGCCTG SEQ ID NO: 723 [00764] Construct pJAQ362 [CD8a Signal Peptide]-[TPO-157 Targeting Domain]- [CD8 trunc Hinge] -[ICAM1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTGACCGAGCTGCTGCTGGTCGTGATGCTGCTGCTCACCGCCAG

ACTGACCCTGAGCAGCCCCGCCCCTCCTGCCTGCGATCTGCGGGTGCTGTCTAAA

CTGCTGCGGGACAGCCACGTGCTGCATTCTAGACTGAGCCAGTGTCCTGAGGTGC

ACCCCCTGCCCACCCCTGTGCTGCTGCCCGCTGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAAATGGAAGAGACAAAGGCCCAAGACATCCTGGGCGCCGTGACCCT

GCTGCTGGAAGGCGTGATGGCCGCTAGAGGCCAGCTGGGCCCTACATGCCTGTC

CAGCCTCCTGGGACAGCTGTCCGGCCAGGTGCGGCTGCTGCTTGGAGCCCTGCAG

AGCCTGCTGGGCACACAGCTGCCACCTCAGGGCAGAACCACAGCCCACAAGGAT

CCTAACGCCATCTTCCTGAGCTTTCAGCACCTGCTGAGAACTACAACTCCAGCAC

CCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCC

TGAAGCCTGTATTGTCATCATCACCGTGGTGGCGGCTGCCGTGATCATGGGCACC

GCCGGTCTCTCCACTTATCTGTACAACCGCCAGCGTAAAATCAAGAAGTACCGCC

TG SEQ ID NO: 724

[00765] Construct pJAQ363 [CD8a Signal Peptide] -[TPO- 163 Targeting Domain]- [CD8 trunc Hinge] -[ICAM1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTGACCGAGCTGCTGCTGGTCGTGATGCTGCTGCTCACAGCCCG

CCTGACACTGAGCAGCCCTGCCCCTCCAGCCTGCGATCTGAGAGTGCTGAGCAA

ACTGCTGAGAGATAGCCACGTGCTGCACAGCAGACTGTCTCAGTGCCCCGAGGT

GCACCCCCTGCCCACCCCTGTGCTGCTGCCTGCCGTGGACTTCAGCCTGGGAGAG

TGGAAGACCCAAATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGAC

CCTGCTGCTGGAAGGCGTGATGGCCGCTAGAGGCCAGCTGGGACCTACCTGTCT

GTCCAGCCTGCTTGGCCAGCTCTCCGGCCAAGTGCGGCTGCTGCTGGGAGCTCTG

CAGAGCCTGCTGGGCACACAGCTGCCTCCTCAGGGCAGAACCACCGCCCATAAG

GACCCCAACGCCATCTTCCTGTCTTTTCAGCACCTGCTGCGGGGCAAGGTGCGGT

TCCTGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAG

TCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGTCATCATCACCGTGGTGGCG

GCTGCCGTGATCATGGGCACCGCCGGTCTCTCCACTTATCTGTACAACCGCCAGC

GTAAAATCAAGAAGTACCGCCTG SEQ ID NO: 725

[00766] Construct pJAQ364 [CD8a Signal Peptide] -[TPO- 171 Targeting Domain] -

[CD8 trunc Hinge] -[ICAM1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGCTGACCGAGCTGCTGCTGGTCGTTATGCTGCTGCTTACAGCCAG

ACTGACACTGTCCAGCCCTGCCCCTCCAGCATGCGACCTGAGGGTGCTGAGCAA

GCTGCTGAGAGATAGCCACGTGCTGCACTCTAGACTGTCTCAGTGCCCCGAGGTG

CACCCTCTGCCCACCCCTGTGCTGCTCCCCGCCGTGGACTTCAGCCTGGGCGAGT

GGAAGACCCAGATGGAAGAAACCAAGGCCCAGGATATCCTGGGCGCTGTGACCC

TGCTGCTGGAAGGCGTGATGGCCGCTAGAGGACAACTGGGACCTACCTGTCTGA

GCAGCCTGCTGGGCCAGCTGTCCGGCCAAGTGCGGCTGCTGCTGGGCGCCCTGC

AGAGCCTGCTCGGCACACAGCTGCCTCCTCAGGGCAGAACCACCGCCCATAAGG ACCCCAACGCCATCTTCCTGAGCTTTCAGCACCTGCTGCGGGGCAAAGTGCGGTT

CCTGATGCTGGTGGGCGGATCTACACTGACTACAACTCCAGCACCCAGACCCCCT

ACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTA

TTGTCATCATCACCGTGGTGGCGGCTGCCGTGATCATGGGCACCGCCGGTCTCTC

CACTTATCTGTACAACCGCCAGCGTAAAATCAAGAAGTACCGCCTG SEQ ID NO: 726

[00767] Construct pJAQ365 [CD8a Signal Peptide]-[CD117 scFv 2D 1 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGATATTGTGATGACCCAGAGCCATAAGTTCATGAGCACCAGCGTGG

GCGATAGAGTGTCCATCACCTGCAAGGCCTCTCAGGACGTGTCTACAACCGTGGC

CTGGTACCAGCAGAAACCTGGCCAGAGCCCTAAGCTGCTGATCTACTCTGCCAGC

TACAGATATACCGGCGTGCCCGACAGATTCACAGGCAGCGGCTCCGGCACAGAC

TTCACCTTCACCATCAGCAGCGTGCAGGCCGAAGATCTGGCCGTTTACTACTGCC

AGCAACACTACAGCACACCTCCAACATTCGGCGGCGGCACCAAGCTGGAAATCA

AAGGCGGTGGAGGCAGCGGAGGCGGAGGCTCTGGCGGCGGCGGCAGCCAAGTG

CAACTCCAGCAGAGTGATGCCGAGCTGGTGAAGCCTGGAGCTTCTGTGAAGATC

AGCTGCAAAGCTTCTGGCTACACCTTTACCGACCACGCCATCCACTGGGTCAAGC

AGCGGCCCGAGCAGGGCCTGGAATGGATCGGCTGTATCTCCCCTGGAAATGGCG

ACATCAAGTACAACGAGAAGTTTAAGGGCAAGGCTACACTGAGCGCCGACAAAA

GCTCTAGCACCGCCTACATGCAGCTGAACAGCCTGACAAGCGAGGACAGCGCCG

TGTATTTCTGCAAGCGGTGGGACTACTTCGACTACTGGGGCCAGGGAACCACCCT

GACCGTGTCCAGCACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACT

ATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGTCATCATCACCG TGGTGGCGGCTGCCGTGATCATGGGCACCGCCGGTCTCTCCACTTATCTGTACAA

CCGCCAGCGTAAAATCAAGAAGTACCGCCTG SEQ ID NO: 727

[00768] Construct pJAQ366 [CD8a Signal Peptide]- [CD 117 scFv 2D2 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAAGTGCAGCTGCAGCAGAGCGACGCCGAGCTGGTGAAGCCCGGAG

CCTCCGTGAAGATCTCCTGCAAGGCTAGCGGCTACACCTTCACCGACCATGCCAT

CCACTGGGTGAAACAGCGGCCTGAGCAGGGCCTGGAATGGATCGGATGTATCAG

CCCCGGCAACGGCGACATCAAATACAATGAGAAGTTCAAGGGCAAGGCTACACT

GTCTGCCGACAAGAGCAGCAGCACCGCCTACATGCAGCTGAACAGCCTCACCAG

CGAGGACAGCGCCGTTTACTTCTGCAAGCGGTGGGACTACTTTGATTATTGGGGA

CAAGGCACCACCCTGACAGTGAGCTCTGGCGGAGGTGGCTCTGGAGGCGGTGGA

TCTGGTGGTGGCGGATCAGATATTGTGATGACCCAGAGCCACAAGTTCATGAGC

ACAAGCGTCGGAGATAGAGTGTCTATCACATGCAAAGCTTCTCAGGACGTGTCC

ACCACCGTGGCCTGGTATCAGCAGAAACCTGGCCAGTCTCCTAAGCTGCTGATCT

ACAGCGCCAGCTACAGATACACAGGCGTGCCAGACAGATTCACCGGCTCTGGTA

GCGGCACAGACTTCACCTTCACCATCTCTAGCGTGCAGGCCGAAGATCTGGCCGT

GTACTACTGCCAGCAACACTACAGCACCCCTCCTACCTTTGGCGGAGGCACAAA

GCTGGAAATCAAGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACT

ATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGTCATCATCACCG

TGGTGGCGGCTGCCGTGATCATGGGCACCGCCGGTCTCTCCACTTATCTGTACAA

CCGCCAGCGTAAAATCAAGAAGTACCGCCTG SEQ ID NO: 728 [00769] Construct pJAQ367 [CD8a Signal Peptide]-[CD117 scFv 4F1 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGACATCGTGATGACCCAGAGCCACAAGTTCATGAGCACCAGCGTGG

GCGATAGAGTGTCCATCACATGCAAGGCCAGCCAGGACGTGTCTACAACCGTGG

CCTGGTACCAGCAGAAACCTGGCCAAAGCCCCAAGCTGCTGATCTACTCCGCCTC

TTACCGGTACACCGGCGTGCCTGACCGGTTCACCGGCAGCGGCTCTGGCACCGAC

TTCACCTTCACCATCAGCAGCGTCCAGGCCGAGGACCTGGCCGTGTACTACTGCC

AGCAGCACTACTCTACCCCTCCAACCTTTGGCGGAGGAACAAAGCTGGAAATCA

AGGGCGGAGGTGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAGAGGTGC

AGCTGCAGGAGAGCGGTCCTAGCCTCGTGAAGCCTTCTCAGACCCTGAGCCTGA

CCTGTAGCGTGACCGGCGACAGCATCACCAGCGGATATTGGAATTGGATCAGAA

AGTTCCCCGGCAACAAGCTGGAATACATGGGCTACATCAACTACAGCGGCAGCA

CGTACTACAACCCCAGCCTGAAAAGCCAGATCAGCATTACCAGAGATACATCTA

AGAACCAGTACTATCTGCAACTGAACAGCGTTACAACAGAGGATGCTGCTACAT

ACTATTGCGCCAGAGGCGGAAATTACTTTGCCATGGACTACTGGGGCCAGGGCA

CCTCCGTGACAGTGTCCAGCACTACAACTCCAGCACCCAGACCCCCTACACCTGC

TCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGTCATC

ATCACCGTGGTGGCGGCTGCCGTGATCATGGGCACCGCCGGTCTCTCCACTTATC

TGTACAACCGCCAGCGTAAAATCAAGAAGTACCGCCTG SEQ ID NO: 729

[00770] Construct pJAQ368 [CD8a Signal Peptide]- [CD 117 scFv 4F2 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAAGTGCAGCTGCAGGAGAGCGGACCTAGCCTGGTGAAGCCTAGCC

AGACCCTGAGCCTGACCTGCAGCGTCACAGGCGACAGCATCACCAGCGGCTACT

GGAACTGGATCAGAAAGTTCCCTGGCAACAAGCTCGAGTACATGGGCTACATCA

ACTACAGCGGCTCCACCTACTACAACCCCAGCCTGAAGTCCCAAATCAGCATTAC

CAGAGATACCAGCAAGAATCAGTACTATCTGCAACTGAACAGCGTGACAACCGA

GGACGCCGCTACATACTATTGCGCCAGAGGCGGCAATTACTTCGCCATGGACTAC

TGGGGCCAGGGCACCAGCGTGACAGTGTCTAGCGGCGGCGGCGGCTCTGGCGGT

GGCGGAAGCGGCGGCGGAGGAAGTGATATCGTGATGACCCAGAGCCACAAGTTT

ATGAGCACATCTGTGGGCGACAGAGTGTCCATCACATGTAAAGCTTCTCAGGAC

GTGTCCACCACCGTGGCCTGGTACCAGCAGAAACCTGGCCAGTCCCCAAAGCTG

CTGATCTACAGCGCCAGCTACCGGTACACCGGCGTTCCTGACCGGTTCACAGGAT

CTGGATCTGGCACAGATTTCACCTTTACCATCAGCAGCGTGCAGGCCGAGGACCT

GGCCGTGTACTATTGCCAGCAGCACTACTCTACACCCCCCACCTTCGGCGGAGGC

ACCAAGCTGGAAATCAAGACTACAACTCCAGCACCCAGACCCCCTACACCTGCT

CCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGTCATCA

TCACCGTGGTGGCGGCTGCCGTGATCATGGGCACCGCCGGTCTCTCCACTTATCT

GTACAACCGCCAGCGTAAAATCAAGAAGTACCGCCTG SEQ ID NO: 730

[00771] Construct pJAQ375 [CD8a Signal Peptide]-[CD117 scFv AHI Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAAGTGCAGCTGCAGCAACCTGGCGCTGAACTGGTCAAGCCCGGCG CCAGCGTGAAAATGAGCTGCAAGGCCAGCGGCTACACATTTACCAGCTATAATA

TGCACTGGGTGAAACAGACCCCTGGCCAGGGCCTCGAGTGGATCGGCGTGATCT

ACAGCGGCAACGGCGACACCAGCTACAACCAGAAATTCAAGGGCAAGGCCACA

CTGACAGCCGATAAGTCCAGCAGCACCGCCTACATGCAGATTAACAGCCTGACC

TCTGAGGATAGCGCCGTTTACTACTGCGCCCGGGAAAGAGATACAAGATTTGGA

AACTGGGGACAGGGAACACTGGTGACCGTGTCTGCCGGCGGAGGTGGCTCTGGA

GGCGGTGGATCTGGTGGTGGCGGATCAAACATCGTGCTGACCCAGAGCCCCGCT

TCTCTGGCCGTGTCCCTGGGCCTGCGGGCTACAATCAGCTGCAGAGCCAGCGAG

AGCGTGGACATCTACGGCAATTCCTTCATGCACTGGTACCAGCAGAAGCCTGGA

CAGCCTCCAAAGCTGCTGATCTACCTGGCTAGCAACCTGGAAAGCGGAGTGCCT

GCCAGGTTCAGCGGCTCTGGCTCTAGAACAGACTTCACCCTGACCATCGACCCCG

TGGAGGCCGACGACGCCGCCACCTACTATTGTCAGCAGAACAACGAGGACCCTT

ACACCTTCGGCGGCGGAACCAAGCTGGAGATCAAGACTACAACTCCAGCACCCA

GACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGA

AGCCTGTATTGTCATCATCACCGTGGTGGCGGCTGCCGTGATCATGGGCACCGCC

GGTCTCTCCACTTATCTGTACAACCGCCAGCGTAAAATCAAGAAGTACCGCCTG

SEQ ID NO: 731

[00772] Construct pJAQ376 [CD8a Signal Peptide]- [CD 117 scFv AH2 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAATATCGTGCTGACACAGAGCCCAGCTAGCCTGGCTGTGTCTCTGGG

CCTGAGAGCCACAATCAGCTGTAGAGCTTCTGAGTCCGTGGACATCTACGGCAAT

AGCTTCATGCACTGGTACCAGCAGAAGCCTGGACAGCCCCCCAAGCTGCTGATCT

ATCTGGCCTCCAACCTGGAAAGCGGAGTGCCTGCCCGGTTCAGCGGCTCCGGCTC

TAGAACCGACTTCACCCTGACCATTGACCCCGTGGAAGCCGACGACGCCGCCAC CTACTACTGCCAGCAGAACAACGAGGATCCTTACACCTTTGGCGGAGGGACCAA

GCTGGAAATCAAGGGCGGAGGTGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGG

ATCACAGGTGCAGCTGCAGCAACCTGGCGCCGAGCTGGTTAAACCTGGTGCTAG

CGTGAAGATGAGCTGCAAGGCCAGCGGCTACACCTTCACCAGCTACAACATGCA

CTGGGTCAAACAGACACCTGGCCAGGGCCTGGAGTGGATCGGCGTGATCTACAG

CGGCAACGGCGATACCTCTTATAACCAGAAATTTAAGGGCAAGGCCACACTCAC

AGCCGATAAGTCCAGCAGCACCGCCTACATGCAGATCAACAGCCTGACAAGCGA

GGACAGCGCCGTGTACTACTGCGCCAGGGAGCGGGACACCAGATTCGGCAACTG

GGGACAAGGCACCCTGGTGACCGTGTCTGCCACTACAACTCCAGCACCCAGACC

CCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCC

TGTATTGTCATCATCACCGTGGTGGCGGCTGCCGTGATCATGGGCACCGCCGGTC

TCTCCACTTATCTGTACAACCGCCAGCGTAAAATCAAGAAGTACCGCCTG

SEQ ID NO: 732

[00773] Construct pJAQ378 [CD8a Signal Peptide]-[CD117 scFv 58 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGTGCAGCTGCTCGAGTCCGGCGGCGGACTGGTGCAGCCCGGCG

GATCTCTGAGACTGTCTTGCGCCGCTAGCGGCTTCACCTTTAGCAACTACGCCAT

GAGCTGGGTGCGGCAGGCCCCTGGAAAAGGCCTGGAATGGGTCAGCGCTATCTC

CGGCAGCGGAGGCTCAACATACTACGCCGACAGCGTTAAGGGAAGATTCACCAT

CAGCCGGGACAACAGCAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGC

CGAGGACACCGCCGTGTACTATTGTGCCAAGGGCCCTCCTACATACCACACCAAT

TACTATTACATGGACGTGTGGGGCAAAGGCACAACAGTGACCGTGAGCAGCGGC

GGAGGTGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAGATATCCAGATG

ACCCAGAGCCCTAGCTCTGTGTCCGCCTCTGTGGGAGATAGAGTGACAATCACCT GCAGAGCCAGCCAGGGCATCAGCAGCTGGCTGGCCTGGTACCAGCAAAAGCCCG

GCAAGGCCCCTAAGCTGCTGATCTACGCTGCTTCTAGCCTGCAAAGCGGCGTGCC

CAGCAGATTCAGCGGTAGCGGCAGCGGCACCGACTTCACACTGACCATTAGCTC

CCTGCAGCCTGAGGATTTCGCCACATACTACTGCCAGCAGACCAACTCTTTTCCA

TACACCTTCGGCGGCGGCACCAAGGTGGAAATCAAGACTACAACTCCAGCACCC

AGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTG

AAGCCTGTATTGTCATCATCACCGTGGTGGCGGCTGCCGTGATCATGGGCACCGC

CGGTCTCTCCACTTATCTGTACAACCGCCAGCGTAAAATCAAGAAGTACCGCCTG

SEQ ID NO: 733

[00774] Construct pJAQ379 [CD8a Signal Peptide]-[CD117 scFv 61 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGTGCAGCTGCTGGAAAGCGGAGGCGGCCTGGTGCAGCCTGGCG

GCTCTCTGCGGCTGTCTTGCGCCGCTAGCGGCTTCACATTTAGCAGCTACGTGAT

GATCTGGGTTAGACAGGCCCCTGGAAAAGGACTGGAGTGGGTCTCCTCTATCAG

CGGCGATAGCGTCACCACCTACTATGCCGACAGCGTGAAGGGCAGATTTACAAT

TAGCAGAGATAACAGCAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGC

CGAGGACACCGCCGTGTACTACTGCGCCAAGGGCCCTCCAACCTACCACACAAA

CTACTACTACATGGACGTGTGGGGCAAAGGCACCACAGTGACCGTGTCCAGCGG

CGGCGGAGGCTCTGGAGGCGGCGGCAGCGGCGGAGGAGGCAGCGACATCCAGA

TGACCCAGAGCCCTAGCTCCGTGTCCGCCTCTGTGGGCGACAGAGTGACAATCAC

CTGCAGAGCCAGCCAGGGTATCAGCTCTTGGCTGGCCTGGTACCAGCAAAAGCC

TGGCAAGGCCCCTAAGCTGCTGATCTACGCTGCTTCTAGCCTGCAAAGCGGAGTG

CCCAGCCGGTTCAGCGGCAGCGGCAGCGGCACTGATTTCACCCTGACAATCTCTT

CCCTCCAGCCCGAGGACTTCGCCACCTACTATTGTCAGCAGACCAATAGCTTCCC CTACACCTTCGGCGGCGGCACAAAGGTGGAAATCAAGACTACAACTCCAGCACC

CAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCT

GAAGCCTGTATTGTCATCATCACCGTGGTGGCGGCTGCCGTGATCATGGGCACCG

CCGGTCTCTCCACTTATCTGTACAACCGCCAGCGTAAAATCAAGAAGTACCGCCT G SEQ ID NO: 734

[00775] Construct pJAQ380 [CD8a Signal Peptide]-[CD117 scFv 66 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGTGCAGCTGGTGGAAAGCGGCGGCGGCCTGGTGCAGCCTGGAG

GCAGCCTGAGACTGAGCTGCGCCGCTAGCGGCTTCACCTTTTCTGATCACTACAT

GGATTGGGTGCGGCAGGCCCCAGGAAAAGGCCTGGAATGGGTCGGACGGACCA

GAAACAAGGCCTCTTCTTATACAACCGAGTACGCTGCTTCTGTGAAGGGCAGGTT

CACAATTAGCCGGGACGACAGCAAGAACAGCCTGTACCTGCAGATGAACAGCCT

GAAGACCGAGGATACCGCCGTGTACTATTGCGCCAGAGAGCCTAAATACTGGAT

CGACTTCGACCTGTGGGGCAGAGGCACCCTGGTTACAGTGTCCAGCGGCGGTGG

CGGCAGCGGCGGCGGAGGCAGCGGAGGCGGAGGCAGCGACATCCAGATGACAC

AGAGCCCTAGCAGCCTCTCCGCCAGCGTGGGAGATAGAGTGACAATCACATGTA

GAGCCTCCCAGTCTATCAGCTCTTACCTGAATTGGTACCAGCAAAAGCCCGGCAA

GGCCCCTAAGCTGCTGATCTACGCCGCCAGCAGCCTGCAAAGCGGCGTGCCCAG

CAGATTCTCCGGCTCCGGCTCTGGCACCGACTTCACCCTGACCATCAGCTCCCTG

CAGCCCGAGGACTTTGCCACCTACTACTGCCAGCAGAGCTACATCGCCCCTTACA

CCTTCGGCGGCGGCACCAAGGTGGAAATCAAGACTACAACTCCAGCACCCAGAC

CCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGC

CTGTATTGTCATCATCACCGTGGTGGCGGCTGCCGTGATCATGGGCACCGCCGGT CTCTCCACTTATCTGTACAACCGCCAGCGTAAAATCAAGAAGTACCGCCTG

SEQ ID NO: 735

[00776] Construct pJAQ381 [CD8a Signal Peptide]-[CD117 scFv 67 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGTGCAGCTGGTGGAAAGCGGCGGAGGCCTGGTTCAGCCCGGCG

GAAGCCTGCGGCTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCGACGCCGACA

TGGACTGGGTGCGGCAGGCCCCTGGAAAAGGCCTGGAATGGGTCGGCCGCACCA

GAAACAAGGCCGGCTCTTATACAACCGAGTACGCTGCTTCTGTGAAGGGCAGAT

TCACAATTTCTAGAGATGACAGCAAGAACAGCCTGTACCTGCAAATGAATTCCCT

GAAGACCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCCTAAGTACTGGAT

CGACTTCGACCTGTGGGGCAGAGGCACACTGGTGACAGTGTCCTCCGGCGGAGG

TGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAGATATCCAGATGACCCA

GAGCCCCAGCAGCCTCAGCGCCAGCGTGGGAGATAGAGTGACCATCACATGCAG

AGCCTCCCAGTCTATCAGCAGCTACCTGAACTGGTACCAGCAGAAGCCCGGCAA

AGCCCCTAAGCTGCTGATCTACGCCGCTTCTTCTCTGCAGAGCGGCGTGCCTAGC

CGGTTCAGCGGCAGCGGCAGCGGTACAGACTTTACCCTGACCATCAGCTCCCTGC

AGCCTGAGGATTTCGCCACCTACTATTGTCAGCAAAGCTACATCGCCCCATACAC

CTTTGGCGGCGGAACCAAGGTGGAAATCAAGACTACAACTCCAGCACCCAGACC

CCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCC

TGTATTGTCATCATCACCGTGGTGGCGGCTGCCGTGATCATGGGCACCGCCGGTC

TCTCCACTTATCTGTACAACCGCCAGCGTAAAATCAAGAAGTACCGCCTG

SEQ ID NO: 736 [00777] Construct pJAQ382 [CD8a Signal Peptide]-[CD117 scFv 68 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGTGCAGCTGGTGGAAAGCGGCGGAGGCCTGGTGCAGCCTGGCC

GGAGCCTGCGGCTGAGCTGCACCGCCAGCGGCTTCACCTTCAGCGACCACGACA

TGAATTGGGTTAGACAGGCCCCTGGCAAAGGCCTGGAATGGGTGGGCCGCACCA

GAAACGCCGCCGGATCTTATACAACAGAGTACGCTGCTTCTGTGAAGGGCCGGT

TCACAATTAGCAGAGATGACAGCAAGAACAGCCTGTACCTGCAAATGAACAGCC

TGAAGACCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCCCAAGTACTGGA

TCGACTTCGACCTGTGGGGCCGGGGCACCCTGGTCACCGTGTCCAGCGGCGGAG

GTGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAGACATCCAGATGACCC

AGTCTCCTAGCAGCCTCAGCGCCAGCGTGGGAGATAGAGTGACCATCACCTGTA

GAGCCAGCCAGAGCATCAGCTCATATCTGAACTGGTACCAGCAGAAACCCGGCA

AGGCCCCTAAGCTGCTGATCTACGCCGCTAGCTCTCTGCAGTCCGGGGTGCCATC

TAGATTCTCCGGCAGCGGCTCTGGAACTGATTTTACACTGACAATCAGCTCCCTT

CAACCCGAGGATTTCGCCACCTACTACTGCCAGCAGAGCTACATCGCCCCTTACA

CCTTTGGCGGCGGCACAAAGGTGGAAATCAAGACTACAACTCCAGCACCCAGAC

CCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGC

CTGTATTGTCATCATCACCGTGGTGGCGGCTGCCGTGATCATGGGCACCGCCGGT

CTCTCCACTTATCTGTACAACCGCCAGCGTAAAATCAAGAAGTACCGCCTG

SEQ ID NO: 737 [00778] Construct pJAQ383 [CD8a Signal Peptide]-[CD117 scFv 69 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGTGCAGCTGGTGGAAAGCGGCGGAGGCCTGGTGCAGCCCGGCG

GCTCCCTGAGACTGAGCTGCGCCGCTTCTGGCTTCACCTTTGTGGACCACGATAT

GGACTGGGTGCGGCAGGCCCCAGGCAAGGGCCTGGAATGGGTCGGAAGAACCA

GAAACAAGCTGGGCTCTTATACAACCGAGTACGCCGCTAGCGTTAAGGGCAGAT

TCACAATCAGCCGCGACGACAGCAAGAATAGCCTGTACCTGCAGATGAACAGCC

TTAAAACCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCCTAAGTACTGGA

TCGACTTCGACCTGTGGGGCCGGGGCACCCTGGTGACAGTGTCCAGCGGAGGCG

GCGGCAGCGGCGGAGGAGGCTCAGGAGGAGGCGGCAGCGATATCCAGATGACA

CAGTCTCCTAGCAGCCTCTCCGCCAGCGTGGGCGATAGAGTGACAATCACCTGCA

GAGCCAGCCAGAGCATCTCCAGCTACCTGAACTGGTACCAGCAAAAGCCTGGAA

AAGCCCCCAAGCTGCTGATCTACGCCGCTTCTTCTCTGCAATCTGGCGTGCCCAG

CCGGTTCAGCGGCTCTGGTAGCGGCACCGACTTCACCCTGACAATTAGCTCCCTG

CAGCCTGAGGATTTTGCCACCTACTATTGTCAGCAGAGCTACATCGCCCCTTACA

CCTTCGGCGGCGGCACCAAGGTGGAAATCAAGACTACAACTCCAGCACCCAGAC

CCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGC

CTGTATTGTCATCATCACCGTGGTGGCGGCTGCCGTGATCATGGGCACCGCCGGT

CTCTCCACTTATCTGTACAACCGCCAGCGTAAAATCAAGAAGTACCGCCTG

SEQ ID NO: 738 [00779] Construct pJAQ384 [CD8a Signal Peptide]- [CD 117 scFv 70 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGTGCAGCTGGTGGAAAGCGGCGGCGGGCTGGTGCAGCCTGGCG

GCAGCCTGCGGCTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCGACTACGCCAT

GAGCTGGGTGCGGCAGGCCCCTGGAAAAGGCCTGGAATGGGTCGCCGTGATCAG

CGAGAACGGCTCCGATACCTACTACGCCGATTCTGTTAAGGGCAGATTCACCATT

AGCCGCGACGACAGCAAGAACACCCTGTACCTGCAAATGAACAGCCTGAGGGCC

GAGGACACCGCCGTGTACTATTGCGCCAGAGATAGAGGCGGCGCCGTGTCCTAC

TTCGACGTGTGGGGACAGGGCACACTGGTCACCGTGTCTTCTGGCGGAGGCGGC

AGCGGCGGCGGCGGCTCTGGCGGCGGCGGATCTGACATCCAGATGACACAGTCC

CCTAGCAGCCTGTCTGCCAGCGTGGGAGATAGAGTGACCATCACCTGTAGAGCC

AGCCAGGACGTGTCCTCTTATCTGGCCTGGTACCAGCAAAAGCCCGGCAAAGCC

CCTAAGCTGCTGATCTACGCTGCTTCTAGCCTCGAGAGCGGCGTGCCCAGCAGAT

TCAGCGGAAGCGGCAGCGGAACAGACTTTACCCTGACAATCAGCTCCCTGCAGC

CAGAGGACTTCGCTACATACTACTGCCAGCAGTACAATAGCCTGCCTTACACATT

TGGCCAGGGCACCAAGGTGGAAATCAAGCGGACCACTACAACTCCAGCACCCAG

ACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAA

GCCTGTATTGTCATCATCACCGTGGTGGCGGCTGCCGTGATCATGGGCACCGCCG

GTCTCTCCACTTATCTGTACAACCGCCAGCGTAAAATCAAGAAGTACCGCCTG

SEQ ID NO: 739 [00780] Construct pJAQ385 [CD8a Signal Peptide]-[CD117 SRI scFv Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAAGTGCAGCTGCAGCAGCCTGGAGCCGAGCTGGTGAAACCTGGCG

CCAGCGTGAAGATGAGCTGCAAGGCCTCCGGTTATACATTCACCTCCTACAACAT

GCACTGGGTCAAACAGACCCCTGGCCAGGGCCTCGAGTGGATCGGCGTGATCTA

CAGCGGCAACGGAGATACCAGCTACAACCAGAAATTCAAGGGCAAGGCCACCCT

GACCGCCGACAAGTCCAGCAGCACCGCCTACATGCAGATCAACAGCCTGACCAG

CGAGGATAGCGCCGTGTACTATTGCGCCAGAGAGCGGGACACCAGATTTGGAAA

TTGGGGCCAAGGCACCCTGGTTACAGTGTCTGCCGCTAAGACCACCGGCGGAGG

TGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAATCGTGCTGACACAGAG

CCCTGCTTCTCTGGCCGTGTCCCTGGGCCTGCGGGCCACAATTAGCTGTAGAGCC

TCTGAGAGCGTGGACATCTACGGCAATAGCTTCATGCACTGGTACCAGCAAAAG

CCTGGCCAGCCCCCCAAGCTGCTGATCTACCTGGCTAGCAACCTGGAAAGCGGC

GTGCCAGCTAGGTTCAGCGGAAGCGGCTCTAGAACCGACTTCACACTGACCATC

GACCCTGTGGAAGCCGATGACGCCGCCACATACTACTGCCAGCAGAACAACGAG

GACCCCTACACCTTTGGCGGCGGAACAAAGCTGGAAATCAAGACTACAACTCCA

GCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGC

GCCCTGAAGCCTGTATTGTCATCATCACCGTGGTGGCGGCTGCCGTGATCATGGG

CACCGCCGGTCTCTCCACTTATCTGTACAACCGCCAGCGTAAAATCAAGAAGTAC

CGCCTG SEQ ID NO: 740 [00781] Construct pJAQ402 [CD8a Signal Peptide]- [CD 117 scFv 54 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAAGTCCAGCTGGTGCAAAGTGGAGCAGAAGTCAAGAAACCCGGAA

GCTCAGTCAAAGTGTCTTGCAAAGCTAGCGGAGGCACGTTCTCAAGTTATGCCAT

ATCCTGGGTGCGCCAAGCGCCCGGCCAAGGCTTGGAATGGATGGGTGGTATAAT

ACCGATTTTTGGGACAGCGAATTATGCACAGAAGTTTCAAGGTAGAGTGACGATT

ACGGCGGATGAAAGTACATCCACGGCGTACATGGAGCTGTCCAGTCTGCGGTCA

GAAGACACAGCCGTATATTACTGCGCGCGAGGAGGGCTCGATACGGACGAATTT

GATCTGTGGGGGCGGGGGACCTTGGTCACAGTAAGTAGCGGGGGAGGAGGCTCT

GGCGGTGGCGGTTCAGGTGGAGGAGGATCCGACATTCAGATGACTCAATCCCCT

TCCTCCCTGAGTGCCTCCGTCGGGGACAGAGTAACGATTACCTGTAGGGCCAGCC

AAAGTATTAACAGCTACCTGAATTGGTATCAGCAGAAGCCCGGCAAAGCCCCGA

AGCTCTTGATATACGCCGCGTCCTCCTTGCAAAGTGGGGTGCCGTCTAGATTCAG

CGGTAGCGGTAGTGGAACGGATTTTACGCTTACTATATCTAGTCTTCAACCGGAG

GATTTTGCTACTTATTATTGTCAACAAGGAGTGTCCGATATCACGTTTGGCGGTG

GGACAAAGGTGGAAATTAAAACTACAACTCCAGCACCCAGACCCCCTACACCTG

CTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGTCAT

CATCACCGTGGTGGCGGCTGCCGTGATCATGGGCACCGCCGGTCTCTCCACTTAT

CTGTACAACCGCCAGCGTAAAATCAAGAAGTACCGCCTGSEQ ID NO: 741 [00782] Construct pJAQ403 [CD8a Signal Peptide]-[CD117 scFv 55 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAAGTTCAGTTGGTTCAGTCCGGCGCTGAAGTTAAAAAGCCCGGAA

GCAGTGTAAAGGTCTCCTGCAAGGCCAGTGGCGGGACATTCCGAATTTACGCCA

TCTCATGGGTCCGACAGGCTCCAGGACAAGGACTTGAGTGGATGGGTGGTATTA

TACCAGACTTCGGGGTTGCCAATTACGCACAAAAATTCCAGGGACGAGTAACTA

TAACTGCGGATGAATCAACCTCTACGGCTTATATGGAGCTCTCATCCTTGCGGTC

AGAAGACACGGCCGTGTATTATTGTGCAAGGGGCGGACTCGACACCGATGAGTT

TGATCTTTGGGGCAGAGGTACTCTGGTGACTGTTAGTAGCGGGGGTGGAGGCTCT

GGCGGAGGGGGAAGTGGCGGAGGAGGGAGCGACATCCAAATGACTCAATCACC

TAGCTCACTTAGCGCAAGCGTTGGCGACCGCGTCACTATTACCTGTCGCGCGTCA

CAATCTATCAACTCATATCTGAATTGGTATCAACAAAAGCCTGGTAAGGCCCCTA

AGCTTCTTATTTATGCAGCCAGTAGCCTTCAATCCGGCGTCCCAAGTCGATTCTCC

GGGAGTGGAAGTGGTACAGATTTTACCCTGACCATAAGCAGTTTGCAGCCGGAA

GACTTTGCTACCTATTATTGCCAACAGGGGGTCTCCGATATTACTTTCGGGGGAG

GCACCAAAGTGGAAATCAAGACTACAACTCCAGCACCCAGACCCCCTACACCTG

CTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGTCAT

CATCACCGTGGTGGCGGCTGCCGTGATCATGGGCACCGCCGGTCTCTCCACTTAT

CTGTACAACCGCCAGCGTAAAATCAAGAAGTACCGCCTGSEQ ID NO: 742 [00783] Construct pJAQ404 [CD8a Signal Peptide]-[CD117 scFv 56 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAGGTGCAGTTGGTGCAGAGTGGTGCAGAGGTAAAGAAACCAGGCA

GCAGTGTAAAGGTCTCCTGCAAAGCTAGTGGAGGGACTTTCTCTCTCTATGCCAT

AAGTTGGGTTCGCCAGGCGCCGGGACAAGGACTCGAATGGATGGGAGGAATCAT

TCCGGCGTTCGGGACAGCCAATTATGCACAGAAATTCCAAGGTAGGGTAACTAT

TACTGCCGATGAGTCAACGTCTACCGCCTATATGGAACTCTCATCCCTTCGAAGC

GAGGACACCGCTGTATACTACTGTGCACGCGGAGGATTGGATACCGATGAATTC

GATCTCTGGGGAAGAGGAACGCTTGTCACGGTAAGCAGTGGCGGTGGCGGGTCT

GGAGGCGGAGGAAGCGGCGGCGGGGGGTCAGACATACAAATGACCCAGAGTCC

ATCAAGTCTGAGTGCTAGTGTAGGAGATCGCGTAACCATTACATGCCGCGCCTCT

CAATCTATCAACTCCTACTTGAACTGGTATCAGCAGAAACCAGGAAAGGCTCCA

AAGTTGTTGATTTATGCAGCTTCTAGTCTCCAGTCAGGAGTACCTTCTCGGTTCTC

CGGATCTGGTAGCGGAACAGACTTCACATTGACCATAAGTAGCTTGCAGCCAGA

AGACTTTGCAACGTATTACTGCCAACAAGGCGTGAGTGACATCACGTTCGGCGG

CGGAACAAAGGTAGAGATTAAAACTACAACTCCAGCACCCAGACCCCCTACACC

TGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGTC

ATCATCACCGTGGTGGCGGCTGCCGTGATCATGGGCACCGCCGGTCTCTCCACTT

ATCTGTACAACCGCCAGCGTAAAATCAAGAAGTACCGCCTG SEQ ID NO: 743 [00784] Construct pJAQ405 [CD8a Signal Peptide]-[CD117 scFv 57 Targeting

Domain] -[CD 8 trunc Hinge] -[IC AMI TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAAGTCCAACTTGTACAATCTGGTGCGGAGGTCAAGAAACCGGGTA

GCTCCGTTAAGGTCTCATGCAAAGCAAGCGGTGGCACTTTCAGTTTGTATGCGAT

CTCTTGGGTGCGGCAAGCGCCAGGACAAGGTCTGGAATGGATGGGTGGGATAAT

ACCTCATTTTGGACTCGCGAATTATGCACAAAAGTTTCAAGGTAGAGTTACAATA

ACCGCGGATGAAAGTACCTCCACCGCATACATGGAGTTGTCAAGCCTTAGGAGT

GAGGACACAGCCGTTTATTACTGTGCCCGAGGCGGATTGGACACTGATGAATTTG

ACTTGTGGGGGAGAGGCACACTCGTAACAGTCAGTAGTGGGGGAGGCGGCTCCG

GAGGCGGCGGTTCTGGCGGCGGAGGTTCCGATATTCAAATGACCCAGAGTCCAA

GTAGTCTTTCCGCATCCGTAGGTGACAGAGTGACTATAACATGCAGGGCATCACA

ATCCATCAACTCTTATCTGAACTGGTACCAACAAAAACCAGGTAAAGCTCCTAAG

CTGCTCATATATGCAGCAAGTTCCCTCCAGAGCGGAGTCCCCTCTCGGTTTTCTG

GTTCCGGAAGCGGAACAGATTTTACGCTCACTATAAGTAGCCTTCAACCTGAGGA

CTTCGCAACATATTACTGTCAACAAGGCGTTTCTGACATCACCTTCGGGGGCGGC

ACCAAGGTCGAGATAAAAACTACAACTCCAGCACCCAGACCCCCTACACCTGCT

CCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGTCATCA

TCACCGTGGTGGCGGCTGCCGTGATCATGGGCACCGCCGGTCTCTCCACTTATCT

GTACAACCGCCAGCGTAAAATCAAGAAGTACCGCCTG SEQ ID NO: 744 [00785] Construct pJAQ436 [Nipah-Gmut TM]-[CD90 scFvl Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCC

CGGCGCAAGCGTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTAC

TGGATCAACTGGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAG

ATTTTCCCCAGTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTA

CGTTGACGGTCGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGAC

CAGTGAGGATTCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTAC

GCTATGGAATACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGAT

AGCAACGCGGGCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAA

AGCCCTACAATAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCT

GCGATTAGTAGCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCAC

CTAAACTTTGGATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTT

TAGTGGAAGTGGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACA

GAAGATGCTACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGG

GGCTGGAACTAAATTGGAGTTGAAG SEQ ID NO: 745

[00786] Construct pJAQ437 [Nipah-Gmut TM]-[CD133 scFv 1 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTGCCGAGGTGCAGCTGCTGGAAAGCGGCGGAGGCCTGGTGCA

GCCTGGCGGCAGCCTGAGACTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCTCC

TACGCCATGAGCTGGGTTAGACAGGCCCCTGGCAAGGGCCTCGAGTGGGTCAGC

GCCATCAGCAGAACCGGCGGCGTGACCAGATACGCCGACAGCGTGAAGGGCAG

ATTCACCATCAGCCGGGACAACTCAAAGAACACCCTGTACCTGCAGATGAACAG

CCTGCGGGCCGAGGATACAGCCGTGTACTACTGCGCCAAGCGGACCAGGCGGTT

CGACTACTGGTGCCAGGGCACCCTGGTGACAGTGTCCAGCAGCCCCAGCTCCCTG TCTGCTTCTGTGGGCGACAGAGTGACCATCACCTGCAGAGCCAGCCAGAGCATC

AGCAGCTACCTGAACTGGTACCAGCAGAAACCTGGAAAAGCCCCTAAGCTGCTG

ATCTACAGCGCTTCTGATCTGCAATCCGGCGTGCCATCTAGATTTTCTGGCAGCG

GATCTGGAACCGATTTTACACTGACCATTTCCAGCCTGCAGCCCGAGGACTTCGC

CACCTACTATTGTCAGCAAACAGCTAATTCTCCTAGCACATTCGGCCAGGGAACA

AAGGTGGAAATC SEQ ID NO: 746

[00787] Construct pJAQ438 [Nipah-Gmut TM]-[CD133 scFv 2 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTGACATCGTGCTGAGCCAGAGCCCAGCTATCATGAGCGCCAG

CCCTGGCGAGAAGGTGACCATCAGCTGCAGCGCTAGCTCCAGCGTGTCTTACATG

TACTGGTACCAGCAAAAGCCCGGCTCTTCTCCAAAGCCCTGGATCTACCGGACCT

CTAATCTGGCCTCTGGCGTGCCCGCCAGATTTTCTGGCAGCGGCAGCGGAACCAG

CTACAGCCTGACAATCAGCAGCATGGAAGCCGAGGATGCCGCTACCTACTACTG

CCAGCAGTACCACAGCTACCCTCCTACCTTCGGCGCCGGCACAAAGCTGGAACT

GAAAAGCTCCGGCGGTGGAGGCAGCGGAGGCGGCGGCGGCGGAAGCTCTAGAA

GCAGCCTGGAAGTGAAACTGGTGGAAAGCGGCCCTGAGCTGAAGAAGCCTGGA

GAAACCGTGAAGATCTCCTGTAAAGCCAGCGGCTATACATTTACCGATTACAGC

ATGAAGTGGGTCAACCAGGCCCCTGGCAAGGGCCTGAAGTGGATGGGCTGGATT

AACACCGAGACCGGCGAGCCTAGCTACGCCGACGACTTCAAGGGCAGATTCGCC

TTCAGCCTCGAGACATCTGCTAGCACCGCCTACCTGCAGATCAACAACCTGAAGA

ACGAGGACACCGCCACATACTTCTGCGCCACCGACTATGGCGATTACTTCGACTA

CTGGGGCCAGGGAACAACACTGACCGTGTCCTCC SEQ ID NO: 747

[00788] Construct pJAQ439 [Nipah-Gmut TM]-[CXCL12 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCG

CTCTGCCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGA

TTCTTCGAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACA

CTCCAAACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAG

TGTGCATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAA

ACAAG SEQ ID NO: 748

[00789] Construct pJAQ440 [Nipah-Gmut TM]-[TPO Genscript Optimized

Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACC

GCCAGGCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGA

GCAAGCTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGA

GGTGCACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGC

GAGTGGAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGT

GACCCTGCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTG

CCTGTCCAGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCC

CTGCAGAGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACAT

AAGGACCCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGC

GGTTTCTGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTAC

CACCGCCGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAAT

AGAACGAGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGC

TCTGGTCTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGA

ACCAGACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACG

AGCTGCTGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGG

GAGCTCCTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACC

TGCAACCTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCT GTTTCCTCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGC

CTGACCCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTA

CACACACAGCCAGAACCTGTCTCAGGAGGGC SEQ ID NO: 749

[00790] Construct pJAQ441 [Nipah-Gmut TM]-[SCF full Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCA

ACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTG

ACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTAC

ATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGA

TCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTT

CAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAA

CATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAA

AAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGA

ATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACAT

CTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGT

GACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGC

AGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGG

GCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCG

CTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCC

AGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAA

TTTCAGGAGGTG SEQ ID NO: 750

[00791] Construct pJAQ442 [Nipah-Gmut TM]-[SCF soluble Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA GCAGTGCACCAGTGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGA

CGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTA

CGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGT

GCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAA

GGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTG

GTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGC

CCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTA

TCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAG

CAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCAT

GCTGCCTCCTGTGGCCGCC SEQ ID NO: 751

[00792] Construct pJAQ443 [Nipah-Gmut TM]-[CALR-ins5 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTCTGCTTAGCGTGCCTCTGCTGCTGGGCCTGCTGGGCCTGGCC

GTGGCCGAACCCGCCGTGTACTTCAAGGAACAGTTCCTCGACGGCGATGGATGG

ACATCTAGATGGATCGAGTCTAAGCATAAGAGCGATTTCGGCAAGTTTGTGCTGA

GCTCCGGCAAGTTCTACGGCGACGAGGAAAAAGATAAGGGCCTGCAGACCAGCC

AAGACGCCAGATTCTACGCTCTGAGCGCCAGCTTCGAGCCCTTCTCCAACAAGGG

CCAGACCCTGGTCGTGCAGTTTACAGTGAAGCACGAGCAGAACATCGATTGCGG

CGGAGGCTACGTGAAGCTGTTCCCCAACTCTCTGGATCAGACAGATATGCACGG

CGACAGCGAGTACAACATCATGTTCGGCCCTGACATCTGTGGCCCCGGCACAAA

GAAAGTGCACGTGATCTTTAACTACAAAGGAAAAAACGTGCTGATCAACAAAGA

CATCAGATGCAAGGACGACGAGTTCACCCACCTGTACACCCTGATTGTGCGGCCT

GATAATACCTACGAGGTGAAGATCGATAACAGCCAGGTCGAGAGCGGCAGCCTG

GAAGACGACTGGGATTTCCTGCCTCCTAAGAAGATCAAGGACCCCGATGCTAGC

AAGCCCGAGGACTGGGACGAGAGAGCCAAGATTGACGACCCTACAGACTCCAA

GCCTGAGGACTGGGACAAGCCCGAGCACATCCCTGATCCTGATGCTAAAAAGCC

TGAGGACTGGGACGAGGAAATGGACGGCGAATGGGAGCCTCCAGTGATCCAGA

ATCCTGAATACAAGGGCGAATGGAAGCCTAGGCAGATCGACAACCCAGACTACA AGGGCACCTGGATCCACCCTGAGATCGACAATCCTGAGTATTCTCCCGACCCCAG

CATCTACGCCTATGATAACTTTGGAGTTCTGGGACTGGACCTGTGGCAGGTGAAG

TCTGGAACCATCTTCGACAACTTCCTGATCACTAACGACGAGGCCTACGCCGAGG

AATTCGGCAACGAGACCTGGGGCGTGACCAAGGCCGCCGAGAAACAGATGAAA

GACAAGCAGGACGAAGAACAGCGGCTGAAGGAAGAAGAGGAAGATAAGAAAA

GAAAGGAAGAAGAGGAGGCTGAGGATAATTGTAGACGGATGATGAGAACCAAG

ATGCGCATGCGGAGAATGAGAAGAACCAGAAGAAAGATGCGGCGGAAGATGAG

CCCTGCCAGACCGCGGACAAGCTGCCGGGAAGCCTGCCTGCAAGGCTGGACCGA

GGCC SEQ ID NO: 752

[00793] Construct pJAQ445 [Nipah-Gmut TM]-[TPO-157 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTGAACTGACCGAGCTGCTGCTGGTCGTGATGCTGCTGCTCACC

GCCAGACTGACCCTGAGCAGCCCCGCCCCTCCTGCCTGCGATCTGCGGGTGCTGT

CTAAACTGCTGCGGGACAGCCACGTGCTGCATTCTAGACTGAGCCAGTGTCCTGA

GGTGCACCCCCTGCCCACCCCTGTGCTGCTGCCCGCTGTGGACTTCAGCCTGGGC

GAGTGGAAGACCCAAATGGAAGAGACAAAGGCCCAAGACATCCTGGGCGCCGT

GACCCTGCTGCTGGAAGGCGTGATGGCCGCTAGAGGCCAGCTGGGCCCTACATG

CCTGTCCAGCCTCCTGGGACAGCTGTCCGGCCAGGTGCGGCTGCTGCTTGGAGCC

CTGCAGAGCCTGCTGGGCACACAGCTGCCACCTCAGGGCAGAACCACAGCCCAC

AAGGATCCTAACGCCATCTTCCTGAGCTTTCAGCACCTGCTGAGA SEQ ID

NO: 753

[00794] Construct pJAQ446 [Nipah-Gmut TM]-[TPO- 171 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA GCAGTGCACCAGTGAGCTGACCGAGCTGCTGCTGGTCGTTATGCTGCTGCTTACA

GCCAGACTGACACTGTCCAGCCCTGCCCCTCCAGCATGCGACCTGAGGGTGCTGA

GCAAGCTGCTGAGAGATAGCCACGTGCTGCACTCTAGACTGTCTCAGTGCCCCGA

GGTGCACCCTCTGCCCACCCCTGTGCTGCTCCCCGCCGTGGACTTCAGCCTGGGC

GAGTGGAAGACCCAGATGGAAGAAACCAAGGCCCAGGATATCCTGGGCGCTGTG

ACCCTGCTGCTGGAAGGCGTGATGGCCGCTAGAGGACAACTGGGACCTACCTGT

CTGAGCAGCCTGCTGGGCCAGCTGTCCGGCCAAGTGCGGCTGCTGCTGGGCGCC

CTGCAGAGCCTGCTCGGCACACAGCTGCCTCCTCAGGGCAGAACCACCGCCCAT

AAGGACCCCAACGCCATCTTCCTGAGCTTTCAGCACCTGCTGCGGGGCAAAGTGC

GGTTCCTGATGCTGGTGGGCGGATCTACACTG SEQ ID NO: 754

[00795] Construct pJAQ447 [Nipah-Gmut TM]-[CD117 scFv 2D1 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTGATATTGTGATGACCCAGAGCCATAAGTTCATGAGCACCAG

CGTGGGCGATAGAGTGTCCATCACCTGCAAGGCCTCTCAGGACGTGTCTACAACC

GTGGCCTGGTACCAGCAGAAACCTGGCCAGAGCCCTAAGCTGCTGATCTACTCTG

CCAGCTACAGATATACCGGCGTGCCCGACAGATTCACAGGCAGCGGCTCCGGCA

CAGACTTCACCTTCACCATCAGCAGCGTGCAGGCCGAAGATCTGGCCGTTTACTA

CTGCCAGCAACACTACAGCACACCTCCAACATTCGGCGGCGGCACCAAGCTGGA

AATCAAAGGCGGTGGAGGCAGCGGAGGCGGAGGCTCTGGCGGCGGCGGCAGCC

AAGTGCAACTCCAGCAGAGTGATGCCGAGCTGGTGAAGCCTGGAGCTTCTGTGA

AGATCAGCTGCAAAGCTTCTGGCTACACCTTTACCGACCACGCCATCCACTGGGT

CAAGCAGCGGCCCGAGCAGGGCCTGGAATGGATCGGCTGTATCTCCCCTGGAAA

TGGCGACATCAAGTACAACGAGAAGTTTAAGGGCAAGGCTACACTGAGCGCCGA

CAAAAGCTCTAGCACCGCCTACATGCAGCTGAACAGCCTGACAAGCGAGGACAG

CGCCGTGTATTTCTGCAAGCGGTGGGACTACTTCGACTACTGGGGCCAGGGAACC

ACCCTGACCGTGTCCAGC SEQ ID NO: 755 [00796] Construct pJAQ448 [Nipah-Gmut TM]-[CD117 scFv 4F1 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTGACATCGTGATGACCCAGAGCCACAAGTTCATGAGCACCAG

CGTGGGCGATAGAGTGTCCATCACATGCAAGGCCAGCCAGGACGTGTCTACAAC

CGTGGCCTGGTACCAGCAGAAACCTGGCCAAAGCCCCAAGCTGCTGATCTACTC

CGCCTCTTACCGGTACACCGGCGTGCCTGACCGGTTCACCGGCAGCGGCTCTGGC

ACCGACTTCACCTTCACCATCAGCAGCGTCCAGGCCGAGGACCTGGCCGTGTACT

ACTGCCAGCAGCACTACTCTACCCCTCCAACCTTTGGCGGAGGAACAAAGCTGG

AAATCAAGGGCGGAGGTGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAG

AGGTGCAGCTGCAGGAGAGCGGTCCTAGCCTCGTGAAGCCTTCTCAGACCCTGA

GCCTGACCTGTAGCGTGACCGGCGACAGCATCACCAGCGGATATTGGAATTGGA

TCAGAAAGTTCCCCGGCAACAAGCTGGAATACATGGGCTACATCAACTACAGCG

GCAGCACGTACTACAACCCCAGCCTGAAAAGCCAGATCAGCATTACCAGAGATA

CATCTAAGAACCAGTACTATCTGCAACTGAACAGCGTTACAACAGAGGATGCTG

CTACATACTATTGCGCCAGAGGCGGAAATTACTTTGCCATGGACTACTGGGGCCA

GGGCACCTCCGTGACAGTGTCCAGC SEQ ID NO: 756

[00797] Construct pJAQ454 [Nipah-Gmut TM]-[CD117 scFv AH2 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTAATATCGTGCTGACACAGAGCCCAGCTAGCCTGGCTGTGTCT

CTGGGCCTGAGAGCCACAATCAGCTGTAGAGCTTCTGAGTCCGTGGACATCTACG

GCAATAGCTTCATGCACTGGTACCAGCAGAAGCCTGGACAGCCCCCCAAGCTGC

TGATCTATCTGGCCTCCAACCTGGAAAGCGGAGTGCCTGCCCGGTTCAGCGGCTC CGGCTCTAGAACCGACTTCACCCTGACCATTGACCCCGTGGAAGCCGACGACGC

CGCCACCTACTACTGCCAGCAGAACAACGAGGATCCTTACACCTTTGGCGGAGG

GACCAAGCTGGAAATCAAGGGCGGAGGTGGCTCTGGAGGCGGTGGATCTGGTGG

TGGCGGATCACAGGTGCAGCTGCAGCAACCTGGCGCCGAGCTGGTTAAACCTGG

TGCTAGCGTGAAGATGAGCTGCAAGGCCAGCGGCTACACCTTCACCAGCTACAA

CATGCACTGGGTCAAACAGACACCTGGCCAGGGCCTGGAGTGGATCGGCGTGAT

CTACAGCGGCAACGGCGATACCTCTTATAACCAGAAATTTAAGGGCAAGGCCAC

ACTCACAGCCGATAAGTCCAGCAGCACCGCCTACATGCAGATCAACAGCCTGAC

AAGCGAGGACAGCGCCGTGTACTACTGCGCCAGGGAGCGGGACACCAGATTCGG

CAACTGGGGACAAGGCACCCTGGTGACCGTGTCTGCC SEQ ID NO: 757

[00798] Construct pJAQ456 [Nipah-Gmut TM]-[CD117 scFv 58 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTGAGGTGCAGCTGCTCGAGTCCGGCGGCGGACTGGTGCAGCC

CGGCGGATCTCTGAGACTGTCTTGCGCCGCTAGCGGCTTCACCTTTAGCAACTAC

GCCATGAGCTGGGTGCGGCAGGCCCCTGGAAAAGGCCTGGAATGGGTCAGCGCT

ATCTCCGGCAGCGGAGGCTCAACATACTACGCCGACAGCGTTAAGGGAAGATTC

ACCATCAGCCGGGACAACAGCAAGAACACCCTGTACCTGCAGATGAACAGCCTG

CGGGCCGAGGACACCGCCGTGTACTATTGTGCCAAGGGCCCTCCTACATACCAC

ACCAATTACTATTACATGGACGTGTGGGGCAAAGGCACAACAGTGACCGTGAGC

AGCGGCGGAGGTGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAGATATC

CAGATGACCCAGAGCCCTAGCTCTGTGTCCGCCTCTGTGGGAGATAGAGTGACA

ATCACCTGCAGAGCCAGCCAGGGCATCAGCAGCTGGCTGGCCTGGTACCAGCAA

AAGCCCGGCAAGGCCCCTAAGCTGCTGATCTACGCTGCTTCTAGCCTGCAAAGCG

GCGTGCCCAGCAGATTCAGCGGTAGCGGCAGCGGCACCGACTTCACACTGACCA

TTAGCTCCCTGCAGCCTGAGGATTTCGCCACATACTACTGCCAGCAGACCAACTC

TTTTCCATACACCTTCGGCGGCGGCACCAAGGTGGAAATCAAG SEQ ID NO: 758 [00799] Construct pJAQ457 [Nipah-Gmut TM]-[CD117 scFv 61 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTGAGGTGCAGCTGCTGGAAAGCGGAGGCGGCCTGGTGCAGCC

TGGCGGCTCTCTGCGGCTGTCTTGCGCCGCTAGCGGCTTCACATTTAGCAGCTAC

GTGATGATCTGGGTTAGACAGGCCCCTGGAAAAGGACTGGAGTGGGTCTCCTCT

ATCAGCGGCGATAGCGTCACCACCTACTATGCCGACAGCGTGAAGGGCAGATTT

ACAATTAGCAGAGATAACAGCAAGAACACCCTGTACCTGCAGATGAACAGCCTG

CGGGCCGAGGACACCGCCGTGTACTACTGCGCCAAGGGCCCTCCAACCTACCAC

ACAAACTACTACTACATGGACGTGTGGGGCAAAGGCACCACAGTGACCGTGTCC

AGCGGCGGCGGAGGCTCTGGAGGCGGCGGCAGCGGCGGAGGAGGCAGCGACAT

CCAGATGACCCAGAGCCCTAGCTCCGTGTCCGCCTCTGTGGGCGACAGAGTGAC

AATCACCTGCAGAGCCAGCCAGGGTATCAGCTCTTGGCTGGCCTGGTACCAGCA

AAAGCCTGGCAAGGCCCCTAAGCTGCTGATCTACGCTGCTTCTAGCCTGCAAAGC

GGAGTGCCCAGCCGGTTCAGCGGCAGCGGCAGCGGCACTGATTTCACCCTGACA

ATCTCTTCCCTCCAGCCCGAGGACTTCGCCACCTACTATTGTCAGCAGACCAATA

GCTTCCCCTACACCTTCGGCGGCGGCACAAAGGTGGAAATCAAG SEQ ID

NO: 759

[00800] Construct pJAQ465 [Nipah-Gmut TM]-[CD117 scFv 55 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTCAAGTTCAGTTGGTTCAGTCCGGCGCTGAAGTTAAAAAGCC

CGGAAGCAGTGTAAAGGTCTCCTGCAAGGCCAGTGGCGGGACATTCCGAATTTA

CGCCATCTCATGGGTCCGACAGGCTCCAGGACAAGGACTTGAGTGGATGGGTGG

TATTATACCAGACTTCGGGGTTGCCAATTACGCACAAAAATTCCAGGGACGAGT

AACTATAACTGCGGATGAATCAACCTCTACGGCTTATATGGAGCTCTCATCCTTG CGGTCAGAAGACACGGCCGTGTATTATTGTGCAAGGGGCGGACTCGACACCGAT

GAGTTTGATCTTTGGGGCAGAGGTACTCTGGTGACTGTTAGTAGCGGGGGTGGAG

GCTCTGGCGGAGGGGGAAGTGGCGGAGGAGGGAGCGACATCCAAATGACTCAA

TCACCTAGCTCACTTAGCGCAAGCGTTGGCGACCGCGTCACTATTACCTGTCGCG

CGTCACAATCTATCAACTCATATCTGAATTGGTATCAACAAAAGCCTGGTAAGGC

CCCTAAGCTTCTTATTTATGCAGCCAGTAGCCTTCAATCCGGCGTCCCAAGTCGA

TTCTCCGGGAGTGGAAGTGGTACAGATTTTACCCTGACCATAAGCAGTTTGCAGC

CGGAAGACTTTGCTACCTATTATTGCCAACAGGGGGTCTCCGATATTACTTTCGG

GGGAGGCACCAAAGTGGAAATCAAG SEQ ID NO: 760

[00801] Construct pJAQ474 [Nipah-Gmut TM]-[AdF35 Genscript Codon Optimized

Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTAC

CCCTACGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCA

GCCCTAATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGAC

CCCTCTCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGAC

CGTGGACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTAT

CACCAAGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCA

GAACAACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGA

TATCTGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCT

AATTGCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTG

CTGGTTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCG

ATACAGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGT

ATTTCGACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCT

GAAAAACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTT

CATGCCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAA

CTACATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCC CTGAACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTAC

GCCATCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATC

GCCACACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAAC

SEQ ID NO: 761

[00802] Construct pJAQ475 [Nipah-Gmut TM]-[TPO-163 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTGAACTGACCGAGCTGCTGCTGGTCGTGATGCTGCTGCTCACA

GCCCGCCTGACACTGAGCAGCCCTGCCCCTCCAGCCTGCGATCTGAGAGTGCTGA

GCAAACTGCTGAGAGATAGCCACGTGCTGCACAGCAGACTGTCTCAGTGCCCCG

AGGTGCACCCCCTGCCCACCCCTGTGCTGCTGCCTGCCGTGGACTTCAGCCTGGG

AGAGTGGAAGACCCAAATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCG

TGACCCTGCTGCTGGAAGGCGTGATGGCCGCTAGAGGCCAGCTGGGACCTACCT

GTCTGTCCAGCCTGCTTGGCCAGCTCTCCGGCCAAGTGCGGCTGCTGCTGGGAGC

TCTGCAGAGCCTGCTGGGCACACAGCTGCCTCCTCAGGGCAGAACCACCGCCCA

TAAGGACCCCAACGCCATCTTCCTGTCTTTTCAGCACCTGCTGCGGGGCAAGGTG

CGGTTCCTG SEQ ID NO: 762

[00803] Construct pJAQ476 [Nipah-Gmut TM]-[CD117 scFv 2D2 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTCAAGTGCAGCTGCAGCAGAGCGACGCCGAGCTGGTGAAGCC

CGGAGCCTCCGTGAAGATCTCCTGCAAGGCTAGCGGCTACACCTTCACCGACCAT

GCCATCCACTGGGTGAAACAGCGGCCTGAGCAGGGCCTGGAATGGATCGGATGT

ATCAGCCCCGGCAACGGCGACATCAAATACAATGAGAAGTTCAAGGGCAAGGCT ACACTGTCTGCCGACAAGAGCAGCAGCACCGCCTACATGCAGCTGAACAGCCTC

ACCAGCGAGGACAGCGCCGTTTACTTCTGCAAGCGGTGGGACTACTTTGATTATT

GGGGACAAGGCACCACCCTGACAGTGAGCTCTGGCGGAGGTGGCTCTGGAGGCG

GTGGATCTGGTGGTGGCGGATCAGATATTGTGATGACCCAGAGCCACAAGTTCA

TGAGCACAAGCGTCGGAGATAGAGTGTCTATCACATGCAAAGCTTCTCAGGACG

TGTCCACCACCGTGGCCTGGTATCAGCAGAAACCTGGCCAGTCTCCTAAGCTGCT

GATCTACAGCGCCAGCTACAGATACACAGGCGTGCCAGACAGATTCACCGGCTC

TGGTAGCGGCACAGACTTCACCTTCACCATCTCTAGCGTGCAGGCCGAAGATCTG

GCCGTGTACTACTGCCAGCAACACTACAGCACCCCTCCTACCTTTGGCGGAGGCA

CAAAGCTGGAAATCAAGSEQ ID NO: 763

[00804] Construct pJAQ477 [Nipah-Gmut TM]-[CD117 scFv 4F2 Targeting

Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTGAAGTGCAGCTGCAGGAGAGCGGACCTAGCCTGGTGAAGCC

TAGCCAGACCCTGAGCCTGACCTGCAGCGTCACAGGCGACAGCATCACCAGCGG

CTACTGGAACTGGATCAGAAAGTTCCCTGGCAACAAGCTCGAGTACATGGGCTA

CATCAACTACAGCGGCTCCACCTACTACAACCCCAGCCTGAAGTCCCAAATCAGC

ATTACCAGAGATACCAGCAAGAATCAGTACTATCTGCAACTGAACAGCGTGACA

ACCGAGGACGCCGCTACATACTATTGCGCCAGAGGCGGCAATTACTTCGCCATG

GACTACTGGGGCCAGGGCACCAGCGTGACAGTGTCTAGCGGCGGCGGCGGCTCT

GGCGGTGGCGGAAGCGGCGGCGGAGGAAGTGATATCGTGATGACCCAGAGCCA

CAAGTTTATGAGCACATCTGTGGGCGACAGAGTGTCCATCACATGTAAAGCTTCT

CAGGACGTGTCCACCACCGTGGCCTGGTACCAGCAGAAACCTGGCCAGTCCCCA

AAGCTGCTGATCTACAGCGCCAGCTACCGGTACACCGGCGTTCCTGACCGGTTCA

CAGGATCTGGATCTGGCACAGATTTCACCTTTACCATCAGCAGCGTGCAGGCCGA

GGACCTGGCCGTGTACTATTGCCAGCAGCACTACTCTACACCCCCCACCTTCGGC

GGAGGCACCAAGCTGGAAATCAAG SEQ ID NO: 764 [00805] Construct pJAQ479 [Nipah-Gmut TM]-[CD117 scFv AHI Targeting

Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTCAAGTGCAGCTGCAGCAACCTGGCGCTGAACTGGTCAAGCC

CGGCGCCAGCGTGAAAATGAGCTGCAAGGCCAGCGGCTACACATTTACCAGCTA

TAATATGCACTGGGTGAAACAGACCCCTGGCCAGGGCCTCGAGTGGATCGGCGT

GATCTACAGCGGCAACGGCGACACCAGCTACAACCAGAAATTCAAGGGCAAGGC

CACACTGACAGCCGATAAGTCCAGCAGCACCGCCTACATGCAGATTAACAGCCT

GACCTCTGAGGATAGCGCCGTTTACTACTGCGCCCGGGAAAGAGATACAAGATT

TGGAAACTGGGGACAGGGAACACTGGTGACCGTGTCTGCCGGCGGAGGTGGCTC

TGGAGGCGGTGGATCTGGTGGTGGCGGATCAAACATCGTGCTGACCCAGAGCCC

CGCTTCTCTGGCCGTGTCCCTGGGCCTGCGGGCTACAATCAGCTGCAGAGCCAGC

GAGAGCGTGGACATCTACGGCAATTCCTTCATGCACTGGTACCAGCAGAAGCCT

GGACAGCCTCCAAAGCTGCTGATCTACCTGGCTAGCAACCTGGAAAGCGGAGTG

CCTGCCAGGTTCAGCGGCTCTGGCTCTAGAACAGACTTCACCCTGACCATCGACC

CCGTGGAGGCCGACGACGCCGCCACCTACTATTGTCAGCAGAACAACGAGGACC

CTTACACCTTCGGCGGCGGAACCAAGCTGGAGATCAAG SEQ ID NO: 765

[00806] Construct pJAQ480 [Nipah-Gmut TM]-[CD117 scFv 66 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTGAGGTGCAGCTGGTGGAAAGCGGCGGCGGCCTGGTGCAGCC

TGGAGGCAGCCTGAGACTGAGCTGCGCCGCTAGCGGCTTCACCTTTTCTGATCAC

TACATGGATTGGGTGCGGCAGGCCCCAGGAAAAGGCCTGGAATGGGTCGGACGG

ACCAGAAACAAGGCCTCTTCTTATACAACCGAGTACGCTGCTTCTGTGAAGGGCA GGTTCACAATTAGCCGGGACGACAGCAAGAACAGCCTGTACCTGCAGATGAACA

GCCTGAAGACCGAGGATACCGCCGTGTACTATTGCGCCAGAGAGCCTAAATACT

GGATCGACTTCGACCTGTGGGGCAGAGGCACCCTGGTTACAGTGTCCAGCGGCG

GTGGCGGCAGCGGCGGCGGAGGCAGCGGAGGCGGAGGCAGCGACATCCAGATG

ACACAGAGCCCTAGCAGCCTCTCCGCCAGCGTGGGAGATAGAGTGACAATCACA

TGTAGAGCCTCCCAGTCTATCAGCTCTTACCTGAATTGGTACCAGCAAAAGCCCG

GCAAGGCCCCTAAGCTGCTGATCTACGCCGCCAGCAGCCTGCAAAGCGGCGTGC

CCAGCAGATTCTCCGGCTCCGGCTCTGGCACCGACTTCACCCTGACCATCAGCTC

CCTGCAGCCCGAGGACTTTGCCACCTACTACTGCCAGCAGAGCTACATCGCCCCT

TACACCTTCGGCGGCGGCACCAAGGTGGAAATCAAG SEQ ID NO: 766

[00807] Construct pJAQ481 [Nipah-Gmut TM]-[CD117 scFv 67 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTGAGGTGCAGCTGGTGGAAAGCGGCGGAGGCCTGGTTCAGCC

CGGCGGAAGCCTGCGGCTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCGACGC

CGACATGGACTGGGTGCGGCAGGCCCCTGGAAAAGGCCTGGAATGGGTCGGCCG

CACCAGAAACAAGGCCGGCTCTTATACAACCGAGTACGCTGCTTCTGTGAAGGG

CAGATTCACAATTTCTAGAGATGACAGCAAGAACAGCCTGTACCTGCAAATGAA

TTCCCTGAAGACCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCCTAAGTA

CTGGATCGACTTCGACCTGTGGGGCAGAGGCACACTGGTGACAGTGTCCTCCGG

CGGAGGTGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAGATATCCAGAT

GACCCAGAGCCCCAGCAGCCTCAGCGCCAGCGTGGGAGATAGAGTGACCATCAC

ATGCAGAGCCTCCCAGTCTATCAGCAGCTACCTGAACTGGTACCAGCAGAAGCC

CGGCAAAGCCCCTAAGCTGCTGATCTACGCCGCTTCTTCTCTGCAGAGCGGCGTG

CCTAGCCGGTTCAGCGGCAGCGGCAGCGGTACAGACTTTACCCTGACCATCAGCT

CCCTGCAGCCTGAGGATTTCGCCACCTACTATTGTCAGCAAAGCTACATCGCCCC

ATACACCTTTGGCGGCGGAACCAAGGTGGAAATCAAG SEQ ID NO: 767 [00808] Construct pJAQ482 [Nipah-Gmut TM]-[CD117 scFv 69 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG

GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTGAGGTGCAGCTGGTGGAAAGCGGCGGAGGCCTGGTGCAGCC

CGGCGGCTCCCTGAGACTGAGCTGCGCCGCTTCTGGCTTCACCTTTGTGGACCAC

GATATGGACTGGGTGCGGCAGGCCCCAGGCAAGGGCCTGGAATGGGTCGGAAG

AACCAGAAACAAGCTGGGCTCTTATACAACCGAGTACGCCGCTAGCGTTAAGGG

CAGATTCACAATCAGCCGCGACGACAGCAAGAATAGCCTGTACCTGCAGATGAA

CAGCCTTAAAACCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCCTAAGTA

CTGGATCGACTTCGACCTGTGGGGCCGGGGCACCCTGGTGACAGTGTCCAGCGG

AGGCGGCGGCAGCGGCGGAGGAGGCTCAGGAGGAGGCGGCAGCGATATCCAGA

TGACACAGTCTCCTAGCAGCCTCTCCGCCAGCGTGGGCGATAGAGTGACAATCA

CCTGCAGAGCCAGCCAGAGCATCTCCAGCTACCTGAACTGGTACCAGCAAAAGC

CTGGAAAAGCCCCCAAGCTGCTGATCTACGCCGCTTCTTCTCTGCAATCTGGCGT

GCCCAGCCGGTTCAGCGGCTCTGGTAGCGGCACCGACTTCACCCTGACAATTAGC

TCCCTGCAGCCTGAGGATTTTGCCACCTACTATTGTCAGCAGAGCTACATCGCCC

CTTACACCTTCGGCGGCGGCACCAAGGTGGAAATCAAG SEQ ID NO: 768

[00809] Construct pJAQ483 [Nipah-Gmut TM]-[CD117 scFv 70 Targeting Domain]

ATGCCTGCTGAAAACAAGAAGGTGCGGTTCGAGAATACCACCTCTGATAAGGGC

AAGATCCCTAGCAAGGTGATCAAGAGCTACTACGGCACCATGGACATCAAGAAA

ATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAACACCGTGATCG

CCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCATCCAGAACTA

CACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGCAGGGCATTCA

GCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCGGTCCAAAGGT

GTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACATCGGACTCCTG GGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGTGAACGAAAA

GTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACATCAGCTGCCCT

AATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTCTCCAACCTG

GTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAGATCCTGAAA

CCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCACCTGCATCA

CCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCATCTGGAACG

AATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGGCGTGGGCGA

AGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAACGTGTGGAC

CCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAACAACGAGTTC

TACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGAACAGCACCT

ACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCAAAAGCAACG

GCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGAAGGGCAGAT

ATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAGACACACTGT

ACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAACGACAGCA

ACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAGACTGAGCA

TGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTCAAATACA

ACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCTGACCAGA

GGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAACCTGTGTT

TTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACGTGCTGACC

GTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAGACCCGGCC

AATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAGGGCGTGTA

CAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCGTGTTCCTG

GACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGATAATGAAA

TCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAAAACCATCA

CCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTCGAGATCTA

CGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAGATTCCAGA

GCAGTGCACCAGTGAGGTGCAGCTGGTGGAAAGCGGCGGCGGGCTGGTGCAGCC

TGGCGGCAGCCTGCGGCTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCGACTAC

GCCATGAGCTGGGTGCGGCAGGCCCCTGGAAAAGGCCTGGAATGGGTCGCCGTG

ATCAGCGAGAACGGCTCCGATACCTACTACGCCGATTCTGTTAAGGGCAGATTCA

CCATTAGCCGCGACGACAGCAAGAACACCCTGTACCTGCAAATGAACAGCCTGA

GGGCCGAGGACACCGCCGTGTACTATTGCGCCAGAGATAGAGGCGGCGCCGTGT

CCTACTTCGACGTGTGGGGACAGGGCACACTGGTCACCGTGTCTTCTGGCGGAGG CGGCAGCGGCGGCGGCGGCTCTGGCGGCGGCGGATCTGACATCCAGATGACACA

GTCCCCTAGCAGCCTGTCTGCCAGCGTGGGAGATAGAGTGACCATCACCTGTAG

AGCCAGCCAGGACGTGTCCTCTTATCTGGCCTGGTACCAGCAAAAGCCCGGCAA

AGCCCCTAAGCTGCTGATCTACGCTGCTTCTAGCCTCGAGAGCGGCGTGCCCAGC

AGATTCAGCGGAAGCGGCAGCGGAACAGACTTTACCCTGACAATCAGCTCCCTG

CAGCCAGAGGACTTCGCTACATACTACTGCCAGCAGTACAATAGCCTGCCTTACA

CATTTGGCCAGGGCACCAAGGTGGAAATCAAGCGGACC SEQ ID NO: 769

[00810] Construct pJAQ500 [CD8a Signal Peptide]-[CD117 scFv 2D 1 Targeting Domain]-[VSV-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGATATTGTGATGACCCAGAGCCATAAGTTCATGAGCACCAGCGTGG

GCGATAGAGTGTCCATCACCTGCAAGGCCTCTCAGGACGTGTCTACAACCGTGGC

CTGGTACCAGCAGAAACCTGGCCAGAGCCCTAAGCTGCTGATCTACTCTGCCAGC

TACAGATATACCGGCGTGCCCGACAGATTCACAGGCAGCGGCTCCGGCACAGAC

TTCACCTTCACCATCAGCAGCGTGCAGGCCGAAGATCTGGCCGTTTACTACTGCC

AGCAACACTACAGCACACCTCCAACATTCGGCGGCGGCACCAAGCTGGAAATCA

AAGGCGGTGGAGGCAGCGGAGGCGGAGGCTCTGGCGGCGGCGGCAGCCAAGTG

CAACTCCAGCAGAGTGATGCCGAGCTGGTGAAGCCTGGAGCTTCTGTGAAGATC

AGCTGCAAAGCTTCTGGCTACACCTTTACCGACCACGCCATCCACTGGGTCAAGC

AGCGGCCCGAGCAGGGCCTGGAATGGATCGGCTGTATCTCCCCTGGAAATGGCG

ACATCAAGTACAACGAGAAGTTTAAGGGCAAGGCTACACTGAGCGCCGACAAAA

GCTCTAGCACCGCCTACATGCAGCTGAACAGCCTGACAAGCGAGGACAGCGCCG

TGTATTTCTGCAAGCGGTGGGACTACTTCGACTACTGGGGCCAGGGAACCACCCT

GACCGTGTCCAGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGAAACTG

GAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAAATTGG

CATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGTCACAAG GCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTGTG

ATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTCACTCC

ATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACTTGGCT

GAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCGAA

GCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAG

AATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCAC

TGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGAT

TCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCAT

CCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTG

GAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCCCAT

CAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCC

TGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTA

AGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAACCT

GGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGC

TCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTAAAA

TACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAA

TGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGATGACTGGG

CACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTTCAG

GATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGATCTTCAT

CTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTTCGC

AACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAATCC

AATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTT

TTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCA

TCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGA

GATGAACCGACTTGGAAAG SEQ ID NO: 770

[00811] Construct pJAQ501 [CD8a Signal Peptide]- [CD 117 scFv 2D2 Targeting

Domain]-[VSV-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAAGTGCAGCTGCAGCAGAGCGACGCCGAGCTGGTGAAGCCCGGAG

CCTCCGTGAAGATCTCCTGCAAGGCTAGCGGCTACACCTTCACCGACCATGCCAT

CCACTGGGTGAAACAGCGGCCTGAGCAGGGCCTGGAATGGATCGGATGTATCAG

CCCCGGCAACGGCGACATCAAATACAATGAGAAGTTCAAGGGCAAGGCTACACT

GTCTGCCGACAAGAGCAGCAGCACCGCCTACATGCAGCTGAACAGCCTCACCAG

CGAGGACAGCGCCGTTTACTTCTGCAAGCGGTGGGACTACTTTGATTATTGGGGA

CAAGGCACCACCCTGACAGTGAGCTCTGGCGGAGGTGGCTCTGGAGGCGGTGGA

TCTGGTGGTGGCGGATCAGATATTGTGATGACCCAGAGCCACAAGTTCATGAGC

ACAAGCGTCGGAGATAGAGTGTCTATCACATGCAAAGCTTCTCAGGACGTGTCC

ACCACCGTGGCCTGGTATCAGCAGAAACCTGGCCAGTCTCCTAAGCTGCTGATCT

ACAGCGCCAGCTACAGATACACAGGCGTGCCAGACAGATTCACCGGCTCTGGTA

GCGGCACAGACTTCACCTTCACCATCTCTAGCGTGCAGGCCGAAGATCTGGCCGT

GTACTACTGCCAGCAACACTACAGCACCCCTCCTACCTTTGGCGGAGGCACAAA

GCTGGAAATCAAGAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGAAACTG

GAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAAATTGG

CATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGTCACAAG

GCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTGTG

ATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTCACTCC

ATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACTTGGCT

GAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCGAA

GCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAG

AATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCAC

TGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGAT

TCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCAT

CCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTG

GAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCCCAT

CAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCC

TGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTA

AGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAACCT

GGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGC

TCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTAAAA TACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAA

TGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGATGACTGGG

CACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTTCAG

GATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGATCTTCAT

CTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTTCGC

AACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAATCC

AATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTT

TTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCA

TCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGA

GATGAACCGACTTGGAAAG SEQ ID NO: 771

[00812] Construct pJAQ508 [CD8a Signal Peptide]-[CD117 scFv AHI Targeting Domain]-[VSV-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAAGTGCAGCTGCAGCAACCTGGCGCTGAACTGGTCAAGCCCGGCG

CCAGCGTGAAAATGAGCTGCAAGGCCAGCGGCTACACATTTACCAGCTATAATA

TGCACTGGGTGAAACAGACCCCTGGCCAGGGCCTCGAGTGGATCGGCGTGATCT

ACAGCGGCAACGGCGACACCAGCTACAACCAGAAATTCAAGGGCAAGGCCACA

CTGACAGCCGATAAGTCCAGCAGCACCGCCTACATGCAGATTAACAGCCTGACC

TCTGAGGATAGCGCCGTTTACTACTGCGCCCGGGAAAGAGATACAAGATTTGGA

AACTGGGGACAGGGAACACTGGTGACCGTGTCTGCCGGCGGAGGTGGCTCTGGA

GGCGGTGGATCTGGTGGTGGCGGATCAAACATCGTGCTGACCCAGAGCCCCGCT

TCTCTGGCCGTGTCCCTGGGCCTGCGGGCTACAATCAGCTGCAGAGCCAGCGAG

AGCGTGGACATCTACGGCAATTCCTTCATGCACTGGTACCAGCAGAAGCCTGGA

CAGCCTCCAAAGCTGCTGATCTACCTGGCTAGCAACCTGGAAAGCGGAGTGCCT

GCCAGGTTCAGCGGCTCTGGCTCTAGAACAGACTTCACCCTGACCATCGACCCCG

TGGAGGCCGACGACGCCGCCACCTACTATTGTCAGCAGAACAACGAGGACCCTT ACACCTTCGGCGGCGGAACCAAGCTGGAGATCAAGAAGTTCACCATAGTTTTTCC ACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCG TCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCA AAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTC CAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACAT TCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAA CGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGC AACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTG GTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGC AGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATA AGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTC AGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTA ACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGC ATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCT CTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCA TCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATT ATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCC

AGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACC

ATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTG

CTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAG

CGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATG

GAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGG

TATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCT

CACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGA

TACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGG

AAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTT

GGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGA

CAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGSEQ ID NO: 772

[00813] Construct pJAQ509 [CD8a Signal Peptide]- [CD 117 scFv AH2 Targeting

Domain]-[VSV-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAATATCGTGCTGACACAGAGCCCAGCTAGCCTGGCTGTGTCTCTGGG

CCTGAGAGCCACAATCAGCTGTAGAGCTTCTGAGTCCGTGGACATCTACGGCAAT

AGCTTCATGCACTGGTACCAGCAGAAGCCTGGACAGCCCCCCAAGCTGCTGATCT

ATCTGGCCTCCAACCTGGAAAGCGGAGTGCCTGCCCGGTTCAGCGGCTCCGGCTC

TAGAACCGACTTCACCCTGACCATTGACCCCGTGGAAGCCGACGACGCCGCCAC

CTACTACTGCCAGCAGAACAACGAGGATCCTTACACCTTTGGCGGAGGGACCAA

GCTGGAAATCAAGGGCGGAGGTGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGG

ATCACAGGTGCAGCTGCAGCAACCTGGCGCCGAGCTGGTTAAACCTGGTGCTAG

CGTGAAGATGAGCTGCAAGGCCAGCGGCTACACCTTCACCAGCTACAACATGCA

CTGGGTCAAACAGACACCTGGCCAGGGCCTGGAGTGGATCGGCGTGATCTACAG

CGGCAACGGCGATACCTCTTATAACCAGAAATTTAAGGGCAAGGCCACACTCAC

AGCCGATAAGTCCAGCAGCACCGCCTACATGCAGATCAACAGCCTGACAAGCGA

GGACAGCGCCGTGTACTACTGCGCCAGGGAGCGGGACACCAGATTCGGCAACTG

GGGACAAGGCACCCTGGTGACCGTGTCTGCCAAGTTCACCATAGTTTTTCCACAC

AACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAA

GCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAAT

GCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAA

ATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCC

ATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACG

AAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAA

CTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGT

TGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAG

CAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAG

GTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAG

AGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACT

ACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATT

GGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTT

TGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCT CAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATT

CCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGT

GGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATA

ATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTG

CTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGG

AACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAG

TTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTAT

GTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCAC

ATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATAC

TGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAA

AGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTT

CTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAG

ATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 773

[00814] Construct pJAQ512 [CD8a Signal Peptide]-[CD117 scFv 58 Targeting Domain]-[VSV-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGTGCAGCTGCTCGAGTCCGGCGGCGGACTGGTGCAGCCCGGCG

GATCTCTGAGACTGTCTTGCGCCGCTAGCGGCTTCACCTTTAGCAACTACGCCAT

GAGCTGGGTGCGGCAGGCCCCTGGAAAAGGCCTGGAATGGGTCAGCGCTATCTC

CGGCAGCGGAGGCTCAACATACTACGCCGACAGCGTTAAGGGAAGATTCACCAT

CAGCCGGGACAACAGCAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGC

CGAGGACACCGCCGTGTACTATTGTGCCAAGGGCCCTCCTACATACCACACCAAT

TACTATTACATGGACGTGTGGGGCAAAGGCACAACAGTGACCGTGAGCAGCGGC

GGAGGTGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAGATATCCAGATG

ACCCAGAGCCCTAGCTCTGTGTCCGCCTCTGTGGGAGATAGAGTGACAATCACCT

GCAGAGCCAGCCAGGGCATCAGCAGCTGGCTGGCCTGGTACCAGCAAAAGCCCG GCAAGGCCCCTAAGCTGCTGATCTACGCTGCTTCTAGCCTGCAAAGCGGCGTGCC

CAGCAGATTCAGCGGTAGCGGCAGCGGCACCGACTTCACACTGACCATTAGCTC

CCTGCAGCCTGAGGATTTCGCCACATACTACTGCCAGCAGACCAACTCTTTTCCA

TACACCTTCGGCGGCGGCACCAAGGTGGAAATCAAGAAGTTCACCATAGTTTTTC

CACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCC

GTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTC

AAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCT

TCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACAC

ATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACA

AACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATAT

GCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGC

TGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAAT

GCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTA

TAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCT

CAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGT

AACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAG

CATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATC

TCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCC

ATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGAT

TATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTC

CAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCAC

CATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATT

GCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAA

GCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAAT

GGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATG

GTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCC

TCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTG

ATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTG

GAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCT

TGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAG

ACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 774 [00815] Construct pJAQ513 [CD8a Signal Peptide]-[CD117 scFv 61 Targeting Domain]-[VSV-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGTGCAGCTGCTGGAAAGCGGAGGCGGCCTGGTGCAGCCTGGCG

GCTCTCTGCGGCTGTCTTGCGCCGCTAGCGGCTTCACATTTAGCAGCTACGTGAT

GATCTGGGTTAGACAGGCCCCTGGAAAAGGACTGGAGTGGGTCTCCTCTATCAG

CGGCGATAGCGTCACCACCTACTATGCCGACAGCGTGAAGGGCAGATTTACAAT

TAGCAGAGATAACAGCAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGC

CGAGGACACCGCCGTGTACTACTGCGCCAAGGGCCCTCCAACCTACCACACAAA

CTACTACTACATGGACGTGTGGGGCAAAGGCACCACAGTGACCGTGTCCAGCGG

CGGCGGAGGCTCTGGAGGCGGCGGCAGCGGCGGAGGAGGCAGCGACATCCAGA

TGACCCAGAGCCCTAGCTCCGTGTCCGCCTCTGTGGGCGACAGAGTGACAATCAC

CTGCAGAGCCAGCCAGGGTATCAGCTCTTGGCTGGCCTGGTACCAGCAAAAGCC

TGGCAAGGCCCCTAAGCTGCTGATCTACGCTGCTTCTAGCCTGCAAAGCGGAGTG

CCCAGCCGGTTCAGCGGCAGCGGCAGCGGCACTGATTTCACCCTGACAATCTCTT

CCCTCCAGCCCGAGGACTTCGCCACCTACTATTGTCAGCAGACCAATAGCTTCCC

CTACACCTTCGGCGGCGGCACAAAGGTGGAAATCAAGAAGTTCACCATAGTTTTT

CCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCC

CGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGT

CAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGC

TTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACA

CATTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAAC

AAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGAT

ATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGT

GCTGGTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAA

ATGCAGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGAC

TATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCT

TCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAA GTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCA

AGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGG

ATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGC

TCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTG

GATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCT

CTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTT

CACCATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGAT

ATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAG

AAGCGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCA

ATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACA

TGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACAT

CCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGG

TGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGT

TGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATT

CTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAA

AGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 775

[00816] Construct pJAQ514 [CD8a Signal Peptide]-[CD117 scFv 67 Targeting Domain]-[VSV-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGTGCAGCTGGTGGAAAGCGGCGGAGGCCTGGTTCAGCCCGGCG

GAAGCCTGCGGCTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCGACGCCGACA

TGGACTGGGTGCGGCAGGCCCCTGGAAAAGGCCTGGAATGGGTCGGCCGCACCA

GAAACAAGGCCGGCTCTTATACAACCGAGTACGCTGCTTCTGTGAAGGGCAGAT

TCACAATTTCTAGAGATGACAGCAAGAACAGCCTGTACCTGCAAATGAATTCCCT

GAAGACCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCCTAAGTACTGGAT

CGACTTCGACCTGTGGGGCAGAGGCACACTGGTGACAGTGTCCTCCGGCGGAGG TGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAGATATCCAGATGACCCA

GAGCCCCAGCAGCCTCAGCGCCAGCGTGGGAGATAGAGTGACCATCACATGCAG

AGCCTCCCAGTCTATCAGCAGCTACCTGAACTGGTACCAGCAGAAGCCCGGCAA

AGCCCCTAAGCTGCTGATCTACGCCGCTTCTTCTCTGCAGAGCGGCGTGCCTAGC

CGGTTCAGCGGCAGCGGCAGCGGTACAGACTTTACCCTGACCATCAGCTCCCTGC

AGCCTGAGGATTTCGCCACCTACTATTGTCAGCAAAGCTACATCGCCCCATACAC

CTTTGGCGGCGGAACCAAGGTGGAAATCAAGAAGTTCACCATAGTTTTTCCACAC

AACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAA

GCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAAT

GCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAA

ATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCC

ATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACG

AAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAA

CTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGT

TGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAG

CAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAG

GTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAG

AGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACT

ACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATT

GGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTT

TGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCT

CAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATT

CCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGT

GGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATA

ATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTG

CTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGG

AACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAG

TTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTAT

GTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCAC

ATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATAC

TGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAA

AGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTT CTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAG

ATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 776

[00817] Construct pJAQ515 [CD8a Signal Peptide]- [CD 117 scFv 70 Targeting Domain]-[VSV-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGTGCAGCTGGTGGAAAGCGGCGGCGGGCTGGTGCAGCCTGGCG

GCAGCCTGCGGCTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCGACTACGCCAT

GAGCTGGGTGCGGCAGGCCCCTGGAAAAGGCCTGGAATGGGTCGCCGTGATCAG

CGAGAACGGCTCCGATACCTACTACGCCGATTCTGTTAAGGGCAGATTCACCATT

AGCCGCGACGACAGCAAGAACACCCTGTACCTGCAAATGAACAGCCTGAGGGCC

GAGGACACCGCCGTGTACTATTGCGCCAGAGATAGAGGCGGCGCCGTGTCCTAC

TTCGACGTGTGGGGACAGGGCACACTGGTCACCGTGTCTTCTGGCGGAGGCGGC

AGCGGCGGCGGCGGCTCTGGCGGCGGCGGATCTGACATCCAGATGACACAGTCC

CCTAGCAGCCTGTCTGCCAGCGTGGGAGATAGAGTGACCATCACCTGTAGAGCC

AGCCAGGACGTGTCCTCTTATCTGGCCTGGTACCAGCAAAAGCCCGGCAAAGCC

CCTAAGCTGCTGATCTACGCTGCTTCTAGCCTCGAGAGCGGCGTGCCCAGCAGAT

TCAGCGGAAGCGGCAGCGGAACAGACTTTACCCTGACAATCAGCTCCCTGCAGC

CAGAGGACTTCGCTACATACTACTGCCAGCAGTACAATAGCCTGCCTTACACATT

TGGCCAGGGCACCAAGGTGGAAATCAAGCGGACCAAGTTCACCATAGTTTTTCC

ACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCG

TCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCA

AAATGCCCCAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTC

CAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACAT

TCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAA

CGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGC

AACTGTGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTG GTTGATGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGC

AGCAATTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATA

AGGTCAAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTC

AGAGGACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTA

ACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGC

ATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCT

CTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCA

TCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATT

ATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCC

AGTGGATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACC

ATAATCAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTG

CTGCTCCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAG

CGGAACTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATG

GAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGG

TATGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCT

CACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGA

TACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGG

AAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTT

GGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGA

CAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGSEQ ID NO: 777

[00818] Construct pJAQ528 [CD8a Signal Peptide]- [CD 117 scFv 54 Targeting Domain]-[VSV-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAAGTCCAGCTGGTGCAAAGTGGAGCAGAAGTCAAGAAACCCGGAA

GCTCAGTCAAAGTGTCTTGCAAAGCTAGCGGAGGCACGTTCTCAAGTTATGCCAT

ATCCTGGGTGCGCCAAGCGCCCGGCCAAGGCTTGGAATGGATGGGTGGTATAAT ACCGATTTTTGGGACAGCGAATTATGCACAGAAGTTTCAAGGTAGAGTGACGATT

ACGGCGGATGAAAGTACATCCACGGCGTACATGGAGCTGTCCAGTCTGCGGTCA

GAAGACACAGCCGTATATTACTGCGCGCGAGGAGGGCTCGATACGGACGAATTT

GATCTGTGGGGGCGGGGGACCTTGGTCACAGTAAGTAGCGGGGGAGGAGGCTCT

GGCGGTGGCGGTTCAGGTGGAGGAGGATCCGACATTCAGATGACTCAATCCCCT

TCCTCCCTGAGTGCCTCCGTCGGGGACAGAGTAACGATTACCTGTAGGGCCAGCC

AAAGTATTAACAGCTACCTGAATTGGTATCAGCAGAAGCCCGGCAAAGCCCCGA

AGCTCTTGATATACGCCGCGTCCTCCTTGCAAAGTGGGGTGCCGTCTAGATTCAG

CGGTAGCGGTAGTGGAACGGATTTTACGCTTACTATATCTAGTCTTCAACCGGAG

GATTTTGCTACTTATTATTGTCAACAAGGAGTGTCCGATATCACGTTTGGCGGTG

GGACAAAGGTGGAAATTAAAAAGTTCACCATAGTTTTTCCACACAACCAAAAAG

GAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTT

AAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAG

TCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACT

ACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCT

TCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAA

CTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGA

TGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATAC

ACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATA

TGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGC

TATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGA

GCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTAT

GAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGA

CTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCA

GATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGT

GGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAA

GAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCT

ATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTAC

CCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTC

TCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGAT

GACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACC

AGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCG

ATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGC TGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCA

AAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGC

CTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGG

TATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 778

[00819] Construct pJAQ529 [CD8a Signal Peptide]-[CD117 scFv 55 Targeting Domain]-[VSV-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAAGTTCAGTTGGTTCAGTCCGGCGCTGAAGTTAAAAAGCCCGGAA

GCAGTGTAAAGGTCTCCTGCAAGGCCAGTGGCGGGACATTCCGAATTTACGCCA

TCTCATGGGTCCGACAGGCTCCAGGACAAGGACTTGAGTGGATGGGTGGTATTA

TACCAGACTTCGGGGTTGCCAATTACGCACAAAAATTCCAGGGACGAGTAACTA

TAACTGCGGATGAATCAACCTCTACGGCTTATATGGAGCTCTCATCCTTGCGGTC

AGAAGACACGGCCGTGTATTATTGTGCAAGGGGCGGACTCGACACCGATGAGTT

TGATCTTTGGGGCAGAGGTACTCTGGTGACTGTTAGTAGCGGGGGTGGAGGCTCT

GGCGGAGGGGGAAGTGGCGGAGGAGGGAGCGACATCCAAATGACTCAATCACC

TAGCTCACTTAGCGCAAGCGTTGGCGACCGCGTCACTATTACCTGTCGCGCGTCA

CAATCTATCAACTCATATCTGAATTGGTATCAACAAAAGCCTGGTAAGGCCCCTA

AGCTTCTTATTTATGCAGCCAGTAGCCTTCAATCCGGCGTCCCAAGTCGATTCTCC

GGGAGTGGAAGTGGTACAGATTTTACCCTGACCATAAGCAGTTTGCAGCCGGAA

GACTTTGCTACCTATTATTGCCAACAGGGGGTCTCCGATATTACTTTCGGGGGAG

GCACCAAAGTGGAAATCAAGAAGTTCACCATAGTTTTTCCACACAACCAAAAAG

GAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTT

AAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAG

TCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACT

ACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCT TCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAA

CTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGA

TGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATAC

ACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATA

TGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGC

TATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGA

GCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTAT

GAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGA

CTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCA

GATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGT

GGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAA

GAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCT

ATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTAC

CCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTC

TCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGAT

GACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACC

AGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCG

ATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGC

TGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCA

AAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGC

CTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGG

TATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 779

[00820] Construct pJAQ530 [CD8a Signal Peptide]-[CD117 scFv 56 Targeting

Domain]-[VSV-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAGGTGCAGTTGGTGCAGAGTGGTGCAGAGGTAAAGAAACCAGGCA

GCAGTGTAAAGGTCTCCTGCAAAGCTAGTGGAGGGACTTTCTCTCTCTATGCCAT

AAGTTGGGTTCGCCAGGCGCCGGGACAAGGACTCGAATGGATGGGAGGAATCAT

TCCGGCGTTCGGGACAGCCAATTATGCACAGAAATTCCAAGGTAGGGTAACTAT

TACTGCCGATGAGTCAACGTCTACCGCCTATATGGAACTCTCATCCCTTCGAAGC

GAGGACACCGCTGTATACTACTGTGCACGCGGAGGATTGGATACCGATGAATTC

GATCTCTGGGGAAGAGGAACGCTTGTCACGGTAAGCAGTGGCGGTGGCGGGTCT

GGAGGCGGAGGAAGCGGCGGCGGGGGGTCAGACATACAAATGACCCAGAGTCC

ATCAAGTCTGAGTGCTAGTGTAGGAGATCGCGTAACCATTACATGCCGCGCCTCT

CAATCTATCAACTCCTACTTGAACTGGTATCAGCAGAAACCAGGAAAGGCTCCA

AAGTTGTTGATTTATGCAGCTTCTAGTCTCCAGTCAGGAGTACCTTCTCGGTTCTC

CGGATCTGGTAGCGGAACAGACTTCACATTGACCATAAGTAGCTTGCAGCCAGA

AGACTTTGCAACGTATTACTGCCAACAAGGCGTGAGTGACATCACGTTCGGCGG

CGGAACAAAGGTAGAGATTAAAAAGTTCACCATAGTTTTTCCACACAACCAAAA

AGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGAT

TTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAG

AGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCA

CTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATC

CTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGG

AACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACG

GATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAAT

ACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACA

TATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGG

GCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGA

GAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCT

TATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTC

AGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAG

CCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTC

AGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGC

CAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTC

AGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATG

GTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAAT CCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTG

GGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAG

GACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGAC

TCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAG

ACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTA

TCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTA

TTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAG

TTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATAC

AGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 780

[00821] Construct pJAQ531 [CD8a Signal Peptide]-[CD117 scFv 57 Targeting Domain]-[VSV-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAAGTCCAACTTGTACAATCTGGTGCGGAGGTCAAGAAACCGGGTA

GCTCCGTTAAGGTCTCATGCAAAGCAAGCGGTGGCACTTTCAGTTTGTATGCGAT

CTCTTGGGTGCGGCAAGCGCCAGGACAAGGTCTGGAATGGATGGGTGGGATAAT

ACCTCATTTTGGACTCGCGAATTATGCACAAAAGTTTCAAGGTAGAGTTACAATA

ACCGCGGATGAAAGTACCTCCACCGCATACATGGAGTTGTCAAGCCTTAGGAGT

GAGGACACAGCCGTTTATTACTGTGCCCGAGGCGGATTGGACACTGATGAATTTG

ACTTGTGGGGGAGAGGCACACTCGTAACAGTCAGTAGTGGGGGAGGCGGCTCCG

GAGGCGGCGGTTCTGGCGGCGGAGGTTCCGATATTCAAATGACCCAGAGTCCAA

GTAGTCTTTCCGCATCCGTAGGTGACAGAGTGACTATAACATGCAGGGCATCACA

ATCCATCAACTCTTATCTGAACTGGTACCAACAAAAACCAGGTAAAGCTCCTAAG

CTGCTCATATATGCAGCAAGTTCCCTCCAGAGCGGAGTCCCCTCTCGGTTTTCTG

GTTCCGGAAGCGGAACAGATTTTACGCTCACTATAAGTAGCCTTCAACCTGAGGA

CTTCGCAACATATTACTGTCAACAAGGCGTTTCTGACATCACCTTCGGGGGCGGC

ACCAAGGTCGAGATAAAAAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGA AACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAA

ATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGTC

ACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTAC

TTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTC

ACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACT

TGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATG

CCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACAC

AGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATG

CCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTA

TGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGC

TATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATG

AAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGAC

TCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAG

ATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTG

GATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAG

AAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTA

TCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCT

CAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGATG

ACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCA

GTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGA

TCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCT

GCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAA

AAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCC

TCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGT

ATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 781

[00822] Construct pJAQ538 [CD90 scFvl Targeting Domain]-[VSV-G mut del SP

TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT

GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT

ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG

GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA

TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA

GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT

ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC

TAAATTGGAGTTGAAGAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGAAA

CTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAAATT

GGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGTCACA

AGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTG

TGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTCACT

CCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACTTGG

CTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCG

AAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACACAGG

AGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATGCCC

CACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGT

GATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTAT

CATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAA

CTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCC

CATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATT

CCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGAT

GTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAA

CCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCT

TGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTA AAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAA

GAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGATGACT

GGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTT

CAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGATCTT

CATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTT

CGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAA

TCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCT

TTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTAT

CCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACAT

AGAGATGAACCGACTTGGAAAG SEQ ID NO: 782

[00823] Construct pJAQ539 [CD133 scFv 2 Targeting Domain]-[VSV-G mut del SP TM]

ATGGACATCGTGCTGAGCCAGAGCCCAGCTATCATGAGCGCCAGCCCTGGCGAG

AAGGTGACCATCAGCTGCAGCGCTAGCTCCAGCGTGTCTTACATGTACTGGTACC

AGCAAAAGCCCGGCTCTTCTCCAAAGCCCTGGATCTACCGGACCTCTAATCTGGC

CTCTGGCGTGCCCGCCAGATTTTCTGGCAGCGGCAGCGGAACCAGCTACAGCCTG

ACAATCAGCAGCATGGAAGCCGAGGATGCCGCTACCTACTACTGCCAGCAGTAC

CACAGCTACCCTCCTACCTTCGGCGCCGGCACAAAGCTGGAACTGAAAAGCTCC

GGCGGTGGAGGCAGCGGAGGCGGCGGCGGCGGAAGCTCTAGAAGCAGCCTGGA

AGTGAAACTGGTGGAAAGCGGCCCTGAGCTGAAGAAGCCTGGAGAAACCGTGA

AGATCTCCTGTAAAGCCAGCGGCTATACATTTACCGATTACAGCATGAAGTGGGT

CAACCAGGCCCCTGGCAAGGGCCTGAAGTGGATGGGCTGGATTAACACCGAGAC

CGGCGAGCCTAGCTACGCCGACGACTTCAAGGGCAGATTCGCCTTCAGCCTCGA

GACATCTGCTAGCACCGCCTACCTGCAGATCAACAACCTGAAGAACGAGGACAC

CGCCACATACTTCTGCGCCACCGACTATGGCGATTACTTCGACTACTGGGGCCAG

GGAACAACACTGACCGTGTCCTCCAAGTTCACCATAGTTTTTCCACACAACCAAA

AAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGA TTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAG

AGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCA

CTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATC

CTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGG

AACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACG

GATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAAT

ACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACA

TATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGG

GCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGA

GAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCT

TATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTC

AGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAG

CCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTC

AGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGC

CAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTC

AGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATG

GTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAAT

CCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTG

GGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAG

GACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGAC

TCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAG

ACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTA

TCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTA

TTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAG

TTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATAC

AGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 783

[00824] Construct pJAQ540 [CD8a Signal Peptide]- [CD 117 scFv 2D2 Targeting

Domain]-[CD8 trunc Hinge]-[VSVG TM tail TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAAGTGCAGCTGCAGCAGAGCGACGCCGAGCTGGTGAAGCCCGGAG

CCTCCGTGAAGATCTCCTGCAAGGCTAGCGGCTACACCTTCACCGACCATGCCAT

CCACTGGGTGAAACAGCGGCCTGAGCAGGGCCTGGAATGGATCGGATGTATCAG

CCCCGGCAACGGCGACATCAAATACAATGAGAAGTTCAAGGGCAAGGCTACACT

GTCTGCCGACAAGAGCAGCAGCACCGCCTACATGCAGCTGAACAGCCTCACCAG

CGAGGACAGCGCCGTTTACTTCTGCAAGCGGTGGGACTACTTTGATTATTGGGGA

CAAGGCACCACCCTGACAGTGAGCTCTGGCGGAGGTGGCTCTGGAGGCGGTGGA

TCTGGTGGTGGCGGATCAGATATTGTGATGACCCAGAGCCACAAGTTCATGAGC

ACAAGCGTCGGAGATAGAGTGTCTATCACATGCAAAGCTTCTCAGGACGTGTCC

ACCACCGTGGCCTGGTATCAGCAGAAACCTGGCCAGTCTCCTAAGCTGCTGATCT

ACAGCGCCAGCTACAGATACACAGGCGTGCCAGACAGATTCACCGGCTCTGGTA

GCGGCACAGACTTCACCTTCACCATCTCTAGCGTGCAGGCCGAAGATCTGGCCGT

GTACTACTGCCAGCAACACTACAGCACCCCTCCTACCTTTGGCGGAGGCACAAA

GCTGGAAATCAAGACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACT

ATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGCCTCTTTTTTCTT

TATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTT

GCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGA

ACCGACTTGGAAAG SEQ ID NO: 784

[00825] Construct pJAQ541 [CD8a Signal Peptide]-[CD117 scFv 4F1 Targeting

Domain]-[CD8 trunc Hinge]-[VSVG TM tail TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGACATCGTGATGACCCAGAGCCACAAGTTCATGAGCACCAGCGTGG

GCGATAGAGTGTCCATCACATGCAAGGCCAGCCAGGACGTGTCTACAACCGTGG

CCTGGTACCAGCAGAAACCTGGCCAAAGCCCCAAGCTGCTGATCTACTCCGCCTC

TTACCGGTACACCGGCGTGCCTGACCGGTTCACCGGCAGCGGCTCTGGCACCGAC

TTCACCTTCACCATCAGCAGCGTCCAGGCCGAGGACCTGGCCGTGTACTACTGCC

AGCAGCACTACTCTACCCCTCCAACCTTTGGCGGAGGAACAAAGCTGGAAATCA

AGGGCGGAGGTGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAGAGGTGC

AGCTGCAGGAGAGCGGTCCTAGCCTCGTGAAGCCTTCTCAGACCCTGAGCCTGA

CCTGTAGCGTGACCGGCGACAGCATCACCAGCGGATATTGGAATTGGATCAGAA

AGTTCCCCGGCAACAAGCTGGAATACATGGGCTACATCAACTACAGCGGCAGCA

CGTACTACAACCCCAGCCTGAAAAGCCAGATCAGCATTACCAGAGATACATCTA

AGAACCAGTACTATCTGCAACTGAACAGCGTTACAACAGAGGATGCTGCTACAT

ACTATTGCGCCAGAGGCGGAAATTACTTTGCCATGGACTACTGGGGCCAGGGCA

CCTCCGTGACAGTGTCCAGCACTACAACTCCAGCACCCAGACCCCCTACACCTGC

TCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGCCTCT

TTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTAT

CCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACAT

AGAGATGAACCGACTTGGAAAG SEQ ID NO: 785

[00826] Construct pJAQ542 [CD8a Signal Peptide]- [CD 117 scFv 4F2 Targeting

Domain]-[CD8 trunc Hinge]-[VSVG TM tail TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAAGTGCAGCTGCAGGAGAGCGGACCTAGCCTGGTGAAGCCTAGCC

AGACCCTGAGCCTGACCTGCAGCGTCACAGGCGACAGCATCACCAGCGGCTACT

GGAACTGGATCAGAAAGTTCCCTGGCAACAAGCTCGAGTACATGGGCTACATCA ACTACAGCGGCTCCACCTACTACAACCCCAGCCTGAAGTCCCAAATCAGCATTAC

CAGAGATACCAGCAAGAATCAGTACTATCTGCAACTGAACAGCGTGACAACCGA

GGACGCCGCTACATACTATTGCGCCAGAGGCGGCAATTACTTCGCCATGGACTAC

TGGGGCCAGGGCACCAGCGTGACAGTGTCTAGCGGCGGCGGCGGCTCTGGCGGT

GGCGGAAGCGGCGGCGGAGGAAGTGATATCGTGATGACCCAGAGCCACAAGTTT

ATGAGCACATCTGTGGGCGACAGAGTGTCCATCACATGTAAAGCTTCTCAGGAC

GTGTCCACCACCGTGGCCTGGTACCAGCAGAAACCTGGCCAGTCCCCAAAGCTG

CTGATCTACAGCGCCAGCTACCGGTACACCGGCGTTCCTGACCGGTTCACAGGAT

CTGGATCTGGCACAGATTTCACCTTTACCATCAGCAGCGTGCAGGCCGAGGACCT

GGCCGTGTACTATTGCCAGCAGCACTACTCTACACCCCCCACCTTCGGCGGAGGC

ACCAAGCTGGAAATCAAGACTACAACTCCAGCACCCAGACCCCCTACACCTGCT

CCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGCCTCTT

TTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATC

CATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATA

GAGATGAACCGACTTGGAAAG SEQ ID NO: 786

[00827] Construct pJAQ548 [CD8a Signal Peptide]-[CD117 scFv AHI Targeting

Domain]-[CD8 trunc Hinge]-[VSVG TM tail TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAAGTGCAGCTGCAGCAACCTGGCGCTGAACTGGTCAAGCCCGGCG

CCAGCGTGAAAATGAGCTGCAAGGCCAGCGGCTACACATTTACCAGCTATAATA

TGCACTGGGTGAAACAGACCCCTGGCCAGGGCCTCGAGTGGATCGGCGTGATCT

ACAGCGGCAACGGCGACACCAGCTACAACCAGAAATTCAAGGGCAAGGCCACA

CTGACAGCCGATAAGTCCAGCAGCACCGCCTACATGCAGATTAACAGCCTGACC

TCTGAGGATAGCGCCGTTTACTACTGCGCCCGGGAAAGAGATACAAGATTTGGA

AACTGGGGACAGGGAACACTGGTGACCGTGTCTGCCGGCGGAGGTGGCTCTGGA GGCGGTGGATCTGGTGGTGGCGGATCAAACATCGTGCTGACCCAGAGCCCCGCT

TCTCTGGCCGTGTCCCTGGGCCTGCGGGCTACAATCAGCTGCAGAGCCAGCGAG

AGCGTGGACATCTACGGCAATTCCTTCATGCACTGGTACCAGCAGAAGCCTGGA

CAGCCTCCAAAGCTGCTGATCTACCTGGCTAGCAACCTGGAAAGCGGAGTGCCT

GCCAGGTTCAGCGGCTCTGGCTCTAGAACAGACTTCACCCTGACCATCGACCCCG

TGGAGGCCGACGACGCCGCCACCTACTATTGTCAGCAGAACAACGAGGACCCTT

ACACCTTCGGCGGCGGAACCAAGCTGGAGATCAAGACTACAACTCCAGCACCCA

GACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGA

AGCCTGTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGT

TCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAG

ATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 787

[00828] Construct pJAQ550 [CD8a Signal Peptide]-[CD117 scFv 58 Targeting

Domain]-[CD8 trunc Hinge]-[VSVG TM tail TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGTGCAGCTGCTCGAGTCCGGCGGCGGACTGGTGCAGCCCGGCG

GATCTCTGAGACTGTCTTGCGCCGCTAGCGGCTTCACCTTTAGCAACTACGCCAT

GAGCTGGGTGCGGCAGGCCCCTGGAAAAGGCCTGGAATGGGTCAGCGCTATCTC

CGGCAGCGGAGGCTCAACATACTACGCCGACAGCGTTAAGGGAAGATTCACCAT

CAGCCGGGACAACAGCAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGC

CGAGGACACCGCCGTGTACTATTGTGCCAAGGGCCCTCCTACATACCACACCAAT

TACTATTACATGGACGTGTGGGGCAAAGGCACAACAGTGACCGTGAGCAGCGGC

GGAGGTGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAGATATCCAGATG

ACCCAGAGCCCTAGCTCTGTGTCCGCCTCTGTGGGAGATAGAGTGACAATCACCT

GCAGAGCCAGCCAGGGCATCAGCAGCTGGCTGGCCTGGTACCAGCAAAAGCCCG

GCAAGGCCCCTAAGCTGCTGATCTACGCTGCTTCTAGCCTGCAAAGCGGCGTGCC CAGCAGATTCAGCGGTAGCGGCAGCGGCACCGACTTCACACTGACCATTAGCTC

CCTGCAGCCTGAGGATTTCGCCACATACTACTGCCAGCAGACCAACTCTTTTCCA

TACACCTTCGGCGGCGGCACCAAGGTGGAAATCAAGACTACAACTCCAGCACCC

AGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTG

AAGCCTGTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTG

GTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGAC

AGATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 788

[00829] Construct pJAQ551 [CD8a Signal Peptide]-[CD117 scFv 61 Targeting

Domain]-[CD8 trunc Hinge]-[VSVG TM tail TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGTGCAGCTGCTGGAAAGCGGAGGCGGCCTGGTGCAGCCTGGCG

GCTCTCTGCGGCTGTCTTGCGCCGCTAGCGGCTTCACATTTAGCAGCTACGTGAT

GATCTGGGTTAGACAGGCCCCTGGAAAAGGACTGGAGTGGGTCTCCTCTATCAG

CGGCGATAGCGTCACCACCTACTATGCCGACAGCGTGAAGGGCAGATTTACAAT

TAGCAGAGATAACAGCAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGC

CGAGGACACCGCCGTGTACTACTGCGCCAAGGGCCCTCCAACCTACCACACAAA

CTACTACTACATGGACGTGTGGGGCAAAGGCACCACAGTGACCGTGTCCAGCGG

CGGCGGAGGCTCTGGAGGCGGCGGCAGCGGCGGAGGAGGCAGCGACATCCAGA

TGACCCAGAGCCCTAGCTCCGTGTCCGCCTCTGTGGGCGACAGAGTGACAATCAC

CTGCAGAGCCAGCCAGGGTATCAGCTCTTGGCTGGCCTGGTACCAGCAAAAGCC

TGGCAAGGCCCCTAAGCTGCTGATCTACGCTGCTTCTAGCCTGCAAAGCGGAGTG

CCCAGCCGGTTCAGCGGCAGCGGCAGCGGCACTGATTTCACCCTGACAATCTCTT

CCCTCCAGCCCGAGGACTTCGCCACCTACTATTGTCAGCAGACCAATAGCTTCCC

CTACACCTTCGGCGGCGGCACAAAGGTGGAAATCAAGACTACAACTCCAGCACC

CAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCT GAAGCCTGTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTT

GGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGA

CAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGSEQ ID NO: 789

[00830] Construct pJAQ552 [CD8a Signal Peptide]- [CD 117 scFv 70 Targeting

Domain]-[CD8 trunc Hinge]-[VSVG TM tail TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGTGCAGCTGGTGGAAAGCGGCGGCGGGCTGGTGCAGCCTGGCG

GCAGCCTGCGGCTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCGACTACGCCAT

GAGCTGGGTGCGGCAGGCCCCTGGAAAAGGCCTGGAATGGGTCGCCGTGATCAG

CGAGAACGGCTCCGATACCTACTACGCCGATTCTGTTAAGGGCAGATTCACCATT

AGCCGCGACGACAGCAAGAACACCCTGTACCTGCAAATGAACAGCCTGAGGGCC

GAGGACACCGCCGTGTACTATTGCGCCAGAGATAGAGGCGGCGCCGTGTCCTAC

TTCGACGTGTGGGGACAGGGCACACTGGTCACCGTGTCTTCTGGCGGAGGCGGC

AGCGGCGGCGGCGGCTCTGGCGGCGGCGGATCTGACATCCAGATGACACAGTCC

CCTAGCAGCCTGTCTGCCAGCGTGGGAGATAGAGTGACCATCACCTGTAGAGCC

AGCCAGGACGTGTCCTCTTATCTGGCCTGGTACCAGCAAAAGCCCGGCAAAGCC

CCTAAGCTGCTGATCTACGCTGCTTCTAGCCTCGAGAGCGGCGTGCCCAGCAGAT

TCAGCGGAAGCGGCAGCGGAACAGACTTTACCCTGACAATCAGCTCCCTGCAGC

CAGAGGACTTCGCTACATACTACTGCCAGCAGTACAATAGCCTGCCTTACACATT

TGGCCAGGGCACCAAGGTGGAAATCAAGCGGACCACTACAACTCCAGCACCCAG

ACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAA

GCCTGTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTT

CTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAG

ATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 790 [00831] Construct pJAQ561 [CD8a Signal Peptide]- [CD 117 scFv 54 Targeting

Domain]-[CD8 trunc Hinge]-[VSVG TM tail TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAAGTCCAGCTGGTGCAAAGTGGAGCAGAAGTCAAGAAACCCGGAA

GCTCAGTCAAAGTGTCTTGCAAAGCTAGCGGAGGCACGTTCTCAAGTTATGCCAT

ATCCTGGGTGCGCCAAGCGCCCGGCCAAGGCTTGGAATGGATGGGTGGTATAAT

ACCGATTTTTGGGACAGCGAATTATGCACAGAAGTTTCAAGGTAGAGTGACGATT

ACGGCGGATGAAAGTACATCCACGGCGTACATGGAGCTGTCCAGTCTGCGGTCA

GAAGACACAGCCGTATATTACTGCGCGCGAGGAGGGCTCGATACGGACGAATTT

GATCTGTGGGGGCGGGGGACCTTGGTCACAGTAAGTAGCGGGGGAGGAGGCTCT

GGCGGTGGCGGTTCAGGTGGAGGAGGATCCGACATTCAGATGACTCAATCCCCT

TCCTCCCTGAGTGCCTCCGTCGGGGACAGAGTAACGATTACCTGTAGGGCCAGCC

AAAGTATTAACAGCTACCTGAATTGGTATCAGCAGAAGCCCGGCAAAGCCCCGA

AGCTCTTGATATACGCCGCGTCCTCCTTGCAAAGTGGGGTGCCGTCTAGATTCAG

CGGTAGCGGTAGTGGAACGGATTTTACGCTTACTATATCTAGTCTTCAACCGGAG

GATTTTGCTACTTATTATTGTCAACAAGGAGTGTCCGATATCACGTTTGGCGGTG

GGACAAAGGTGGAAATTAAAACTACAACTCCAGCACCCAGACCCCCTACACCTG

CTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGCCTC

TTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTAT

CCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACAT

AGAGATGAACCGACTTGGAAAG SEQ ID NO: 791 [00832] Construct pJAQ562 [CD8a Signal Peptide]-[CD117 scFv 56 Targeting

Domain]-[CD8 trunc Hinge]-[VSVG TM tail TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAGGTGCAGTTGGTGCAGAGTGGTGCAGAGGTAAAGAAACCAGGCA

GCAGTGTAAAGGTCTCCTGCAAAGCTAGTGGAGGGACTTTCTCTCTCTATGCCAT

AAGTTGGGTTCGCCAGGCGCCGGGACAAGGACTCGAATGGATGGGAGGAATCAT

TCCGGCGTTCGGGACAGCCAATTATGCACAGAAATTCCAAGGTAGGGTAACTAT

TACTGCCGATGAGTCAACGTCTACCGCCTATATGGAACTCTCATCCCTTCGAAGC

GAGGACACCGCTGTATACTACTGTGCACGCGGAGGATTGGATACCGATGAATTC

GATCTCTGGGGAAGAGGAACGCTTGTCACGGTAAGCAGTGGCGGTGGCGGGTCT

GGAGGCGGAGGAAGCGGCGGCGGGGGGTCAGACATACAAATGACCCAGAGTCC

ATCAAGTCTGAGTGCTAGTGTAGGAGATCGCGTAACCATTACATGCCGCGCCTCT

CAATCTATCAACTCCTACTTGAACTGGTATCAGCAGAAACCAGGAAAGGCTCCA

AAGTTGTTGATTTATGCAGCTTCTAGTCTCCAGTCAGGAGTACCTTCTCGGTTCTC

CGGATCTGGTAGCGGAACAGACTTCACATTGACCATAAGTAGCTTGCAGCCAGA

AGACTTTGCAACGTATTACTGCCAACAAGGCGTGAGTGACATCACGTTCGGCGG

CGGAACAAAGGTAGAGATTAAAACTACAACTCCAGCACCCAGACCCCCTACACC

TGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGCC

TCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGT

ATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 792 [00833] Construct pJAQ567 [CD8a.2 Signal Peptide] -[SCF soluble 2 Targeting

Domain] -[GGGGSx3 Linker] -[TPO- 145 Targeting Domain] -[GGGGSx3 Linker] -[FLT3L

Targeting Domain]-[CD8 trunc Hinge]-[VSVG TM tail TM]

ATGGCTTTGCCTGTTACAGCTCTGCTGCTGCCCCTGGCTCTGCTTCTGCATGCTGC

TAGACCTGAGGGCATCTGCCGGAACAGAGTGACCAACAACGTGAAGGACGTGAC

CAAGCTGGTGGCCAACCTGCCTAAGGACTACATGATCACCCTGAAATACGTGCC

CGGCATGGACGTGCTGCCTAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCT

GAGCGACAGCCTGACCGACCTGCTGGACAAGTTCAGCAACATCAGCGAGGGCCT

GAGCAACTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTGGA

ATGCGTGAAAGAGAACAGCAGCAAGGACCTGAAGAAGTCCTTCAAGAGCCCCG

AGCCTCGGCTGTTCACCCCTGAGGAATTCTTCCGGATCTTCAACCGGTCCATCGA

CGCCTTCAAGGACTTCGTGGTGGCCAGCGAGACAAGCGACTGTGTGGTTTCTGGT

GGCGGAGGATCTGGCGGAGGTGGAAGCGGCGGAGGCGGATCTTGCGATCTGAG

AGTGCTGAGCAAGCTGCTGAGAGACAGCCACGTGCTGCACAGCAGACTGAGCCA

GTGTCCTGAAGTGCACCCTCTGCCTACACCTGTGCTGCTGCCTGCTGTGGATTTCA

GCCTCGGCGAGTGGAAAACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTG

GGAGCCGTGACACTGCTTCTGGAAGGCGTGATGGCTGCCAGAGGACAGCTGGGA

CCTACATGTCTGTCTAGCCTGCTGGGCCAGCTGTCTGGACAAGTTCGACTGCTGC

TGGGAGCCCTGCAATCTCTGCTGGGAACACAGCTGCCTCCACAGGGCAGAACAA

CAGCCCACAAGGACCCCAACGCCATCTTCCTGAGCTTCCAGCACCTCCTGAGAGG

CAAAGTGCGGTTCCTGATGCTCGTCGGCGGCAGCACACTTTGTGGTGGCGGAGG

ATCTGGCGGAGGTGGAAGCGGCGGAGGCGGATCTGACTGCAGCTTTCAGCACAG

CCCCATCAGCAGCGACTTCGCCGTGAAGATCAGAGAGCTGAGCGACTACCTGCT GCAGGACTACCCTGTGACCGTGGCCAGCAATCTGCAGGACGAAGAACTGTGTGG

TGGCCTGTGGCGACTGGTGCTGGCTCAGAGATGGATGGAACGGCTGAAAACAGT

GGCCGGCAGCAAGATGCAGGGCCTGCTGGAAAGAGTGAACACCGAGATCCACTT

CGTGACCAAGTGCGCCTTCCAGCCTCCTCCAAGCTGCCTGAGATTCGTGCAGACC

AACATCAGCAGACTGCTGCAAGAGACAAGCGAGCAGCTGGTGGCCCTGAAGCCT

TGGATCACCAGACAGAACTTCAGCCGGTGCCTGGAACTGCAGTGTGCGGCCGCA

ATTGAAGTTATGTATCCTCCTCCTTACCTAGACAATGAGAAGAGCAATGGAACCA

TTATCCATGTGAAAGGGAAACACCTTTGTCCAAGTCCCCTATTTCCCGGACCTTC

TAAGCCCACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCA

AGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGCCTCTTTTTTCTTTATCAT

AGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTA

AATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGAC

TTGGAAAG SEQ ID NO: 793

[00834] Construct pJAQ568 [Nipah G mut trunc TM]-[CD133 scFv 2 Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTGACATCGTGCTGAGCCAGAGCCCAGCTATCATG

AGCGCCAGCCCTGGCGAGAAGGTGACCATCAGCTGCAGCGCTAGCTCCAGCGTG

TCTTACATGTACTGGTACCAGCAAAAGCCCGGCTCTTCTCCAAAGCCCTGGATCT

ACCGGACCTCTAATCTGGCCTCTGGCGTGCCCGCCAGATTTTCTGGCAGCGGCAG

CGGAACCAGCTACAGCCTGACAATCAGCAGCATGGAAGCCGAGGATGCCGCTAC

CTACTACTGCCAGCAGTACCACAGCTACCCTCCTACCTTCGGCGCCGGCACAAAG

CTGGAACTGAAAAGCTCCGGCGGTGGAGGCAGCGGAGGCGGCGGCGGCGGAAG

CTCTAGAAGCAGCCTGGAAGTGAAACTGGTGGAAAGCGGCCCTGAGCTGAAGAA

GCCTGGAGAAACCGTGAAGATCTCCTGTAAAGCCAGCGGCTATACATTTACCGA

TTACAGCATGAAGTGGGTCAACCAGGCCCCTGGCAAGGGCCTGAAGTGGATGGG

CTGGATTAACACCGAGACCGGCGAGCCTAGCTACGCCGACGACTTCAAGGGCAG

ATTCGCCTTCAGCCTCGAGACATCTGCTAGCACCGCCTACCTGCAGATCAACAAC

CTGAAGAACGAGGACACCGCCACATACTTCTGCGCCACCGACTATGGCGATTAC

TTCGACTACTGGGGCCAGGGAACAACACTGACCGTGTCCTCC SEQ ID NO: 794 [00835] Construct pJAQ569 [Nipah G mut trunc TM]-[CXCL12 Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGC

TGACCGCGCTCTGCCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCC

CATGCCGATTCTTCGAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAAT

TCTCAACACTCCAAACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAAC

AGACAAGTGTGCATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAA

GCTTTAAACAAG SEQ ID NO: 795

[00836] Construct pJAQ570 [Nipah G mut trunc TM]-[SCF soluble Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTGAGGGCATCTGCAGAAATCGGGTGACCAACAAC

GTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACC

CTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAG

ATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAAC

ATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGG

ACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTT

TCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAA

CCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGC

GTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAG

CCATTCATGCTGCCTCCTGTGGCCGCC SEQ ID NO: 796

[00837] Construct pJAQ571 [Nipah G mut trunc TM]-[TPO-157 Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTGAACTGACCGAGCTGCTGCTGGTCGTGATGCTGC TGCTCACCGCCAGACTGACCCTGAGCAGCCCCGCCCCTCCTGCCTGCGATCTGCG

GGTGCTGTCTAAACTGCTGCGGGACAGCCACGTGCTGCATTCTAGACTGAGCCAG

TGTCCTGAGGTGCACCCCCTGCCCACCCCTGTGCTGCTGCCCGCTGTGGACTTCA

GCCTGGGCGAGTGGAAGACCCAAATGGAAGAGACAAAGGCCCAAGACATCCTG

GGCGCCGTGACCCTGCTGCTGGAAGGCGTGATGGCCGCTAGAGGCCAGCTGGGC

CCTACATGCCTGTCCAGCCTCCTGGGACAGCTGTCCGGCCAGGTGCGGCTGCTGC

TTGGAGCCCTGCAGAGCCTGCTGGGCACACAGCTGCCACCTCAGGGCAGAACCA

CAGCCCACAAGGATCCTAACGCCATCTTCCTGAGCTTTCAGCACCTGCTGAGA

SEQ ID NO: 797

[00838] Construct pJAQ572 [Nipah G mut trunc TM]-[TPO-171 Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTGAGCTGACCGAGCTGCTGCTGGTCGTTATGCTGC

TGCTTACAGCCAGACTGACACTGTCCAGCCCTGCCCCTCCAGCATGCGACCTGAG

GGTGCTGAGCAAGCTGCTGAGAGATAGCCACGTGCTGCACTCTAGACTGTCTCA

GTGCCCCGAGGTGCACCCTCTGCCCACCCCTGTGCTGCTCCCCGCCGTGGACTTC

AGCCTGGGCGAGTGGAAGACCCAGATGGAAGAAACCAAGGCCCAGGATATCCT

GGGCGCTGTGACCCTGCTGCTGGAAGGCGTGATGGCCGCTAGAGGACAACTGGG

ACCTACCTGTCTGAGCAGCCTGCTGGGCCAGCTGTCCGGCCAAGTGCGGCTGCTG

CTGGGCGCCCTGCAGAGCCTGCTCGGCACACAGCTGCCTCCTCAGGGCAGAACC

ACCGCCCATAAGGACCCCAACGCCATCTTCCTGAGCTTTCAGCACCTGCTGCGGG

GCAAAGTGCGGTTCCTGATGCTGGTGGGCGGATCTACACTG SEQ ID NO: 798

[00839] Construct pJAQ575 [Nipah G mut trunc TM]-[CD117 scFv 58 Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTGAGGTGCAGCTGCTCGAGTCCGGCGGCGGACTG

GTGCAGCCCGGCGGATCTCTGAGACTGTCTTGCGCCGCTAGCGGCTTCACCTTTA GCAACTACGCCATGAGCTGGGTGCGGCAGGCCCCTGGAAAAGGCCTGGAATGGG

TCAGCGCTATCTCCGGCAGCGGAGGCTCAACATACTACGCCGACAGCGTTAAGG

GAAGATTCACCATCAGCCGGGACAACAGCAAGAACACCCTGTACCTGCAGATGA

ACAGCCTGCGGGCCGAGGACACCGCCGTGTACTATTGTGCCAAGGGCCCTCCTA

CATACCACACCAATTACTATTACATGGACGTGTGGGGCAAAGGCACAACAGTGA

CCGTGAGCAGCGGCGGAGGTGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGAT

CAGATATCCAGATGACCCAGAGCCCTAGCTCTGTGTCCGCCTCTGTGGGAGATAG

AGTGACAATCACCTGCAGAGCCAGCCAGGGCATCAGCAGCTGGCTGGCCTGGTA

CCAGCAAAAGCCCGGCAAGGCCCCTAAGCTGCTGATCTACGCTGCTTCTAGCCTG

CAAAGCGGCGTGCCCAGCAGATTCAGCGGTAGCGGCAGCGGCACCGACTTCACA

CTGACCATTAGCTCCCTGCAGCCTGAGGATTTCGCCACATACTACTGCCAGCAGA

CCAACTCTTTTCCATACACCTTCGGCGGCGGCACCAAGGTGGAAATCAAG

SEQ ID NO: 799

[00840] Construct pJAQ577 [Nipah G mut trunc TM]-[CD117 scFv 55 Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTCAAGTTCAGTTGGTTCAGTCCGGCGCTGAAGTTA

AAAAGCCCGGAAGCAGTGTAAAGGTCTCCTGCAAGGCCAGTGGCGGGACATTCC

GAATTTACGCCATCTCATGGGTCCGACAGGCTCCAGGACAAGGACTTGAGTGGA

TGGGTGGTATTATACCAGACTTCGGGGTTGCCAATTACGCACAAAAATTCCAGGG

ACGAGTAACTATAACTGCGGATGAATCAACCTCTACGGCTTATATGGAGCTCTCA

TCCTTGCGGTCAGAAGACACGGCCGTGTATTATTGTGCAAGGGGCGGACTCGAC

ACCGATGAGTTTGATCTTTGGGGCAGAGGTACTCTGGTGACTGTTAGTAGCGGGG

GTGGAGGCTCTGGCGGAGGGGGAAGTGGCGGAGGAGGGAGCGACATCCAAATG

ACTCAATCACCTAGCTCACTTAGCGCAAGCGTTGGCGACCGCGTCACTATTACCT

GTCGCGCGTCACAATCTATCAACTCATATCTGAATTGGTATCAACAAAAGCCTGG

TAAGGCCCCTAAGCTTCTTATTTATGCAGCCAGTAGCCTTCAATCCGGCGTCCCA

AGTCGATTCTCCGGGAGTGGAAGTGGTACAGATTTTACCCTGACCATAAGCAGTT

TGCAGCCGGAAGACTTTGCTACCTATTATTGCCAACAGGGGGTCTCCGATATTAC

TTTCGGGGGAGGCACCAAAGTGGAAATCAAG SEQ ID NO: 800 [00841] Construct pJAQ579 [Nipah G mut trunc TM]-[AdF35 Genscript Codon

Optimized Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAAT

CCTGTGTACCCCTACGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCG

GCTTCATCAGCCCTAATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAA

GTGCCTGACCCCTCTCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGG

AGGACTGACCGTGGACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCA

CCGCCCCTATCACCAAGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCC

TGGAAACCCAGAACAACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCA

ACAACGGAGATATCTGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCA

ACCCTCCACCTAATTGCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGC

TGACACTCGTGCTGGTTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGT

CGGCGTGTCCGATACAGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCA

GCTGAGACTGTATTTCGACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTG

AAAATCCCCCTGAAAAACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGC

AGCAAGGCCTTCATGCCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGG

ACAGCGAGAACTACATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAA

GCCTGTTCCCCCTGAACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCA

ACGTGGCTTACGCCATCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTG

AGTCTAATATCGCCACACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAA

GATGACAAC SEQ ID NO: 801

[00842] Construct pJAQ580 [Nipah G mut trunc TM]-[CD117 scFv AHI Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTCAAGTGCAGCTGCAGCAACCTGGCGCTGAACTG GTCAAGCCCGGCGCCAGCGTGAAAATGAGCTGCAAGGCCAGCGGCTACACATTT

ACCAGCTATAATATGCACTGGGTGAAACAGACCCCTGGCCAGGGCCTCGAGTGG

ATCGGCGTGATCTACAGCGGCAACGGCGACACCAGCTACAACCAGAAATTCAAG

GGCAAGGCCACACTGACAGCCGATAAGTCCAGCAGCACCGCCTACATGCAGATT

AACAGCCTGACCTCTGAGGATAGCGCCGTTTACTACTGCGCCCGGGAAAGAGAT

ACAAGATTTGGAAACTGGGGACAGGGAACACTGGTGACCGTGTCTGCCGGCGGA

GGTGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAAACATCGTGCTGACC

CAGAGCCCCGCTTCTCTGGCCGTGTCCCTGGGCCTGCGGGCTACAATCAGCTGCA

GAGCCAGCGAGAGCGTGGACATCTACGGCAATTCCTTCATGCACTGGTACCAGC

AGAAGCCTGGACAGCCTCCAAAGCTGCTGATCTACCTGGCTAGCAACCTGGAAA

GCGGAGTGCCTGCCAGGTTCAGCGGCTCTGGCTCTAGAACAGACTTCACCCTGAC

CATCGACCCCGTGGAGGCCGACGACGCCGCCACCTACTATTGTCAGCAGAACAA

CGAGGACCCTTACACCTTCGGCGGCGGAACCAAGCTGGAGATCAAG SEQ ID NO: 802

[00843] Construct pJAQ581 [Nipah G mut trunc TM]-[CD117 scFv 66 Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTGAGGTGCAGCTGGTGGAAAGCGGCGGCGGCCTG

GTGCAGCCTGGAGGCAGCCTGAGACTGAGCTGCGCCGCTAGCGGCTTCACCTTTT

CTGATCACTACATGGATTGGGTGCGGCAGGCCCCAGGAAAAGGCCTGGAATGGG

TCGGACGGACCAGAAACAAGGCCTCTTCTTATACAACCGAGTACGCTGCTTCTGT

GAAGGGCAGGTTCACAATTAGCCGGGACGACAGCAAGAACAGCCTGTACCTGCA

GATGAACAGCCTGAAGACCGAGGATACCGCCGTGTACTATTGCGCCAGAGAGCC

TAAATACTGGATCGACTTCGACCTGTGGGGCAGAGGCACCCTGGTTACAGTGTCC

AGCGGCGGTGGCGGCAGCGGCGGCGGAGGCAGCGGAGGCGGAGGCAGCGACAT

CCAGATGACACAGAGCCCTAGCAGCCTCTCCGCCAGCGTGGGAGATAGAGTGAC

AATCACATGTAGAGCCTCCCAGTCTATCAGCTCTTACCTGAATTGGTACCAGCAA

AAGCCCGGCAAGGCCCCTAAGCTGCTGATCTACGCCGCCAGCAGCCTGCAAAGC

GGCGTGCCCAGCAGATTCTCCGGCTCCGGCTCTGGCACCGACTTCACCCTGACCA TCAGCTCCCTGCAGCCCGAGGACTTTGCCACCTACTACTGCCAGCAGAGCTACAT

CGCCCCTTACACCTTCGGCGGCGGCACCAAGGTGGAAATCAAG SEQ ID NO: 803

[00844] Construct pJAQ582 [Nipah G mut trunc TM]-[CD117 scFv 67 Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTGAGGTGCAGCTGGTGGAAAGCGGCGGAGGCCTG

GTTCAGCCCGGCGGAAGCCTGCGGCTGAGCTGCGCCGCTAGCGGCTTCACCTTCA

GCGACGCCGACATGGACTGGGTGCGGCAGGCCCCTGGAAAAGGCCTGGAATGGG

TCGGCCGCACCAGAAACAAGGCCGGCTCTTATACAACCGAGTACGCTGCTTCTGT

GAAGGGCAGATTCACAATTTCTAGAGATGACAGCAAGAACAGCCTGTACCTGCA

AATGAATTCCCTGAAGACCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCC

TAAGTACTGGATCGACTTCGACCTGTGGGGCAGAGGCACACTGGTGACAGTGTC

CTCCGGCGGAGGTGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAGATAT

CCAGATGACCCAGAGCCCCAGCAGCCTCAGCGCCAGCGTGGGAGATAGAGTGAC

CATCACATGCAGAGCCTCCCAGTCTATCAGCAGCTACCTGAACTGGTACCAGCAG

AAGCCCGGCAAAGCCCCTAAGCTGCTGATCTACGCCGCTTCTTCTCTGCAGAGCG

GCGTGCCTAGCCGGTTCAGCGGCAGCGGCAGCGGTACAGACTTTACCCTGACCA

TCAGCTCCCTGCAGCCTGAGGATTTCGCCACCTACTATTGTCAGCAAAGCTACAT

CGCCCCATACACCTTTGGCGGCGGAACCAAGGTGGAAATCAAG SEQ ID NO: 804

[00845] Construct pJAQ583 [Nipah G mut trunc TM]-[CD117 scFv 70 Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTGAGGTGCAGCTGGTGGAAAGCGGCGGCGGGCTG

GTGCAGCCTGGCGGCAGCCTGCGGCTGAGCTGCGCCGCTAGCGGCTTCACCTTCA

GCGACTACGCCATGAGCTGGGTGCGGCAGGCCCCTGGAAAAGGCCTGGAATGGG

TCGCCGTGATCAGCGAGAACGGCTCCGATACCTACTACGCCGATTCTGTTAAGGG

CAGATTCACCATTAGCCGCGACGACAGCAAGAACACCCTGTACCTGCAAATGAA CAGCCTGAGGGCCGAGGACACCGCCGTGTACTATTGCGCCAGAGATAGAGGCGG

CGCCGTGTCCTACTTCGACGTGTGGGGACAGGGCACACTGGTCACCGTGTCTTCT

GGCGGAGGCGGCAGCGGCGGCGGCGGCTCTGGCGGCGGCGGATCTGACATCCAG

ATGACACAGTCCCCTAGCAGCCTGTCTGCCAGCGTGGGAGATAGAGTGACCATC

ACCTGTAGAGCCAGCCAGGACGTGTCCTCTTATCTGGCCTGGTACCAGCAAAAGC

CCGGCAAAGCCCCTAAGCTGCTGATCTACGCTGCTTCTAGCCTCGAGAGCGGCGT

GCCCAGCAGATTCAGCGGAAGCGGCAGCGGAACAGACTTTACCCTGACAATCAG

CTCCCTGCAGCCAGAGGACTTCGCTACATACTACTGCCAGCAGTACAATAGCCTG

CCTTACACATTTGGCCAGGGCACCAAGGTGGAAATCAAGCGGACC SEQ ID

NO: 805

[00846] Construct pJAQ587 [Nipah G mut trunc TM]-[SCF full Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTAAAAAAACCCAGACCTGGATCCTGACATGCATC

TACCTCCAACTGCTCCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAA

ATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCA

AGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCC

ACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCT

GGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAA

GCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAA

GGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGA

ATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCC

TCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCA

GAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAG

AAACGACAGCAGCAGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCA

GCCTGCACTGGGCCGCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTT

CGCCTTCGGCGCTCTGTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGT

GGAAAACATCCAGATTAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGA

AGGAACGGGAATTTCAGGAGGTG SEQ ID NO: 806 [00847] Construct pJAQ588 [Nipah G mut trunc TM]-[CALR-ins5 Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTCTGCTTAGCGTGCCTCTGCTGCTGGGCCTGCTGG

GCCTGGCCGTGGCCGAACCCGCCGTGTACTTCAAGGAACAGTTCCTCGACGGCG

ATGGATGGACATCTAGATGGATCGAGTCTAAGCATAAGAGCGATTTCGGCAAGT

TTGTGCTGAGCTCCGGCAAGTTCTACGGCGACGAGGAAAAAGATAAGGGCCTGC

AGACCAGCCAAGACGCCAGATTCTACGCTCTGAGCGCCAGCTTCGAGCCCTTCTC

CAACAAGGGCCAGACCCTGGTCGTGCAGTTTACAGTGAAGCACGAGCAGAACAT

CGATTGCGGCGGAGGCTACGTGAAGCTGTTCCCCAACTCTCTGGATCAGACAGAT

ATGCACGGCGACAGCGAGTACAACATCATGTTCGGCCCTGACATCTGTGGCCCC

GGCACAAAGAAAGTGCACGTGATCTTTAACTACAAAGGAAAAAACGTGCTGATC

AACAAAGACATCAGATGCAAGGACGACGAGTTCACCCACCTGTACACCCTGATT

GTGCGGCCTGATAATACCTACGAGGTGAAGATCGATAACAGCCAGGTCGAGAGC

GGCAGCCTGGAAGACGACTGGGATTTCCTGCCTCCTAAGAAGATCAAGGACCCC

GATGCTAGCAAGCCCGAGGACTGGGACGAGAGAGCCAAGATTGACGACCCTACA

GACTCCAAGCCTGAGGACTGGGACAAGCCCGAGCACATCCCTGATCCTGATGCT

AAAAAGCCTGAGGACTGGGACGAGGAAATGGACGGCGAATGGGAGCCTCCAGT

GATCCAGAATCCTGAATACAAGGGCGAATGGAAGCCTAGGCAGATCGACAACCC

AGACTACAAGGGCACCTGGATCCACCCTGAGATCGACAATCCTGAGTATTCTCCC

GACCCCAGCATCTACGCCTATGATAACTTTGGAGTTCTGGGACTGGACCTGTGGC

AGGTGAAGTCTGGAACCATCTTCGACAACTTCCTGATCACTAACGACGAGGCCTA

CGCCGAGGAATTCGGCAACGAGACCTGGGGCGTGACCAAGGCCGCCGAGAAAC

AGATGAAAGACAAGCAGGACGAAGAACAGCGGCTGAAGGAAGAAGAGGAAGA

TAAGAAAAGAAAGGAAGAAGAGGAGGCTGAGGATAATTGTAGACGGATGATGA

GAACCAAGATGCGCATGCGGAGAATGAGAAGAACCAGAAGAAAGATGCGGCGG

AAGATGAGCCCTGCCAGACCGCGGACAAGCTGCCGGGAAGCCTGCCTGCAAGGC

TGGACCGAGGCC SEQ ID NO: 807

[00848] Construct pJAQ590 [Nipah G mut trunc TM]-[CD117 scFv AH2 Targeting

Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTAATATCGTGCTGACACAGAGCCCAGCTAGCCTG

GCTGTGTCTCTGGGCCTGAGAGCCACAATCAGCTGTAGAGCTTCTGAGTCCGTGG

ACATCTACGGCAATAGCTTCATGCACTGGTACCAGCAGAAGCCTGGACAGCCCC

CCAAGCTGCTGATCTATCTGGCCTCCAACCTGGAAAGCGGAGTGCCTGCCCGGTT

CAGCGGCTCCGGCTCTAGAACCGACTTCACCCTGACCATTGACCCCGTGGAAGCC

GACGACGCCGCCACCTACTACTGCCAGCAGAACAACGAGGATCCTTACACCTTT

GGCGGAGGGACCAAGCTGGAAATCAAGGGCGGAGGTGGCTCTGGAGGCGGTGG

ATCTGGTGGTGGCGGATCACAGGTGCAGCTGCAGCAACCTGGCGCCGAGCTGGT

TAAACCTGGTGCTAGCGTGAAGATGAGCTGCAAGGCCAGCGGCTACACCTTCAC

CAGCTACAACATGCACTGGGTCAAACAGACACCTGGCCAGGGCCTGGAGTGGAT

CGGCGTGATCTACAGCGGCAACGGCGATACCTCTTATAACCAGAAATTTAAGGG

CAAGGCCACACTCACAGCCGATAAGTCCAGCAGCACCGCCTACATGCAGATCAA

CAGCCTGACAAGCGAGGACAGCGCCGTGTACTACTGCGCCAGGGAGCGGGACAC

CAGATTCGGCAACTGGGGACAAGGCACCCTGGTGACCGTGTCTGCC SEQ ID NO: 808

[00849] Construct pJAQ591 [Nipah G mut trunc TM]-[CD117 scFv 4F2 Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTGAAGTGCAGCTGCAGGAGAGCGGACCTAGCCTG

GTGAAGCCTAGCCAGACCCTGAGCCTGACCTGCAGCGTCACAGGCGACAGCATC

ACCAGCGGCTACTGGAACTGGATCAGAAAGTTCCCTGGCAACAAGCTCGAGTAC

ATGGGCTACATCAACTACAGCGGCTCCACCTACTACAACCCCAGCCTGAAGTCCC

AAATCAGCATTACCAGAGATACCAGCAAGAATCAGTACTATCTGCAACTGAACA

GCGTGACAACCGAGGACGCCGCTACATACTATTGCGCCAGAGGCGGCAATTACT

TCGCCATGGACTACTGGGGCCAGGGCACCAGCGTGACAGTGTCTAGCGGCGGCG

GCGGCTCTGGCGGTGGCGGAAGCGGCGGCGGAGGAAGTGATATCGTGATGACCC

AGAGCCACAAGTTTATGAGCACATCTGTGGGCGACAGAGTGTCCATCACATGTA

AAGCTTCTCAGGACGTGTCCACCACCGTGGCCTGGTACCAGCAGAAACCTGGCC AGTCCCCAAAGCTGCTGATCTACAGCGCCAGCTACCGGTACACCGGCGTTCCTGA

CCGGTTCACAGGATCTGGATCTGGCACAGATTTCACCTTTACCATCAGCAGCGTG

CAGGCCGAGGACCTGGCCGTGTACTATTGCCAGCAGCACTACTCTACACCCCCCA

CCTTCGGCGGAGGCACCAAGCTGGAAATCAAG SEQ ID NO: 809

[00850] Construct pJAQ595 [CD8a Signal Peptide]-[CD117 scFv 4F1 Targeting

Domain]-[VSV-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGACATCGTGATGACCCAGAGCCACAAGTTCATGAGCACCAGCGTGG

GCGATAGAGTGTCCATCACATGCAAGGCCAGCCAGGACGTGTCTACAACCGTGG

CCTGGTACCAGCAGAAACCTGGCCAAAGCCCCAAGCTGCTGATCTACTCCGCCTC

TTACCGGTACACCGGCGTGCCTGACCGGTTCACCGGCAGCGGCTCTGGCACCGAC

TTCACCTTCACCATCAGCAGCGTCCAGGCCGAGGACCTGGCCGTGTACTACTGCC

AGCAGCACTACTCTACCCCTCCAACCTTTGGCGGAGGAACAAAGCTGGAAATCA

AGGGCGGAGGTGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAGAGGTGC

AGCTGCAGGAGAGCGGTCCTAGCCTCGTGAAGCCTTCTCAGACCCTGAGCCTGA

CCTGTAGCGTGACCGGCGACAGCATCACCAGCGGATATTGGAATTGGATCAGAA

AGTTCCCCGGCAACAAGCTGGAATACATGGGCTACATCAACTACAGCGGCAGCA

CGTACTACAACCCCAGCCTGAAAAGCCAGATCAGCATTACCAGAGATACATCTA

AGAACCAGTACTATCTGCAACTGAACAGCGTTACAACAGAGGATGCTGCTACAT

ACTATTGCGCCAGAGGCGGAAATTACTTTGCCATGGACTACTGGGGCCAGGGCA

CCTCCGTGACAGTGTCCAGCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGG

AAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTA

AATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGT

CACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTA

CTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTT

CACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAAC TTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGAT

GCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACA

CAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATAT

GCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCT

ATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAG

CTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATG

AAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGAC

TCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAG

ATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTG

GATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAG

AAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTA

TCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCT

CAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGATG

ACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCA

GTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGA

TCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCT

GCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAA

AAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCC

TCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGT

ATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 810

[00851] Construct pJAQ596 [CD8a Signal Peptide]- [CD 117 scFv 4F2 Targeting Domain]-[VSV-G mut del SP TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAAGTGCAGCTGCAGGAGAGCGGACCTAGCCTGGTGAAGCCTAGCC AGACCCTGAGCCTGACCTGCAGCGTCACAGGCGACAGCATCACCAGCGGCTACT

GGAACTGGATCAGAAAGTTCCCTGGCAACAAGCTCGAGTACATGGGCTACATCA

ACTACAGCGGCTCCACCTACTACAACCCCAGCCTGAAGTCCCAAATCAGCATTAC

CAGAGATACCAGCAAGAATCAGTACTATCTGCAACTGAACAGCGTGACAACCGA

GGACGCCGCTACATACTATTGCGCCAGAGGCGGCAATTACTTCGCCATGGACTAC

TGGGGCCAGGGCACCAGCGTGACAGTGTCTAGCGGCGGCGGCGGCTCTGGCGGT

GGCGGAAGCGGCGGCGGAGGAAGTGATATCGTGATGACCCAGAGCCACAAGTTT

ATGAGCACATCTGTGGGCGACAGAGTGTCCATCACATGTAAAGCTTCTCAGGAC

GTGTCCACCACCGTGGCCTGGTACCAGCAGAAACCTGGCCAGTCCCCAAAGCTG

CTGATCTACAGCGCCAGCTACCGGTACACCGGCGTTCCTGACCGGTTCACAGGAT

CTGGATCTGGCACAGATTTCACCTTTACCATCAGCAGCGTGCAGGCCGAGGACCT

GGCCGTGTACTATTGCCAGCAGCACTACTCTACACCCCCCACCTTCGGCGGAGGC

ACCAAGCTGGAAATCAAGAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGA

AACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAA

ATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGTC

ACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTAC

TTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTC

ACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACT

TGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATG

CCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACAC

AGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATG

CCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTA

TGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGC

TATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATG

AAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGAC

TCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAG

ATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTG

GATGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAG

AAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTA

TCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCT

CAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGATG

ACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCA GTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGA

TCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCT

GCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAA

AAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCC

TCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGT

ATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 811

[00852] Construct pJAQ601 [CD133 scFv 1 Targeting Domain]-[VSV-G mut del SP TM]

ATGGCCGAGGTGCAGCTGCTGGAAAGCGGCGGAGGCCTGGTGCAGCCTGGCGGC

AGCCTGAGACTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCTCCTACGCCATGA

GCTGGGTTAGACAGGCCCCTGGCAAGGGCCTCGAGTGGGTCAGCGCCATCAGCA

GAACCGGCGGCGTGACCAGATACGCCGACAGCGTGAAGGGCAGATTCACCATCA

GCCGGGACAACTCAAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGCCG

AGGATACAGCCGTGTACTACTGCGCCAAGCGGACCAGGCGGTTCGACTACTGGT

GCCAGGGCACCCTGGTGACAGTGTCCAGCAGCCCCAGCTCCCTGTCTGCTTCTGT

GGGCGACAGAGTGACCATCACCTGCAGAGCCAGCCAGAGCATCAGCAGCTACCT

GAACTGGTACCAGCAGAAACCTGGAAAAGCCCCTAAGCTGCTGATCTACAGCGC

TTCTGATCTGCAATCCGGCGTGCCATCTAGATTTTCTGGCAGCGGATCTGGAACC

GATTTTACACTGACCATTTCCAGCCTGCAGCCCGAGGACTTCGCCACCTACTATT

GTCAGCAAACAGCTAATTCTCCTAGCACATTCGGCCAGGGAACAAAGGTGGAAA

TCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCC

TTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAA

TAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAG

ACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTAT

GGACCGAAGTATATAACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAAT

GCAAGGAAAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCC CTCCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCA

GGTGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCA

CAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTA

CAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTC

CATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGA

GGGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTG

CAAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTC

GAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAG

GGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGA

CGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAG

AGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCA

GGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCA

GATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGAT

CAGTGGAACTACCACAGAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGA

CGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCT

TTATACATGATTGGACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGG

CTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGA

TGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTA

GAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGG

GTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAAT

TAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTG

GAAAG SEQ ID NO: 812

[00853] Construct pJAQ602 [CD8a.2 Signal Peptide] -[SCF soluble 2 Targeting

Domain] -[GGGGSx3 Linker] -[TPO- 145 Targeting Domain] -[GGGGSx3 Linker] -[FLT3L Targeting Domain]- [VS V-G mut del SP TM]

ATGGCTTTGCCTGTTACAGCTCTGCTGCTGCCCCTGGCTCTGCTTCTGCATGCTGC

TAGACCTGAGGGCATCTGCCGGAACAGAGTGACCAACAACGTGAAGGACGTGAC

CAAGCTGGTGGCCAACCTGCCTAAGGACTACATGATCACCCTGAAATACGTGCC

CGGCATGGACGTGCTGCCTAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCT

GAGCGACAGCCTGACCGACCTGCTGGACAAGTTCAGCAACATCAGCGAGGGCCT

GAGCAACTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTGGA

ATGCGTGAAAGAGAACAGCAGCAAGGACCTGAAGAAGTCCTTCAAGAGCCCCG

AGCCTCGGCTGTTCACCCCTGAGGAATTCTTCCGGATCTTCAACCGGTCCATCGA

CGCCTTCAAGGACTTCGTGGTGGCCAGCGAGACAAGCGACTGTGTGGTTTCTGGT

GGCGGAGGATCTGGCGGAGGTGGAAGCGGCGGAGGCGGATCTTGCGATCTGAG

AGTGCTGAGCAAGCTGCTGAGAGACAGCCACGTGCTGCACAGCAGACTGAGCCA

GTGTCCTGAAGTGCACCCTCTGCCTACACCTGTGCTGCTGCCTGCTGTGGATTTCA

GCCTCGGCGAGTGGAAAACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTG

GGAGCCGTGACACTGCTTCTGGAAGGCGTGATGGCTGCCAGAGGACAGCTGGGA

CCTACATGTCTGTCTAGCCTGCTGGGCCAGCTGTCTGGACAAGTTCGACTGCTGC

TGGGAGCCCTGCAATCTCTGCTGGGAACACAGCTGCCTCCACAGGGCAGAACAA

CAGCCCACAAGGACCCCAACGCCATCTTCCTGAGCTTCCAGCACCTCCTGAGAGG

CAAAGTGCGGTTCCTGATGCTCGTCGGCGGCAGCACACTTTGTGGTGGCGGAGG

ATCTGGCGGAGGTGGAAGCGGCGGAGGCGGATCTGACTGCAGCTTTCAGCACAG

CCCCATCAGCAGCGACTTCGCCGTGAAGATCAGAGAGCTGAGCGACTACCTGCT

GCAGGACTACCCTGTGACCGTGGCCAGCAATCTGCAGGACGAAGAACTGTGTGG

TGGCCTGTGGCGACTGGTGCTGGCTCAGAGATGGATGGAACGGCTGAAAACAGT

GGCCGGCAGCAAGATGCAGGGCCTGCTGGAAAGAGTGAACACCGAGATCCACTT

CGTGACCAAGTGCGCCTTCCAGCCTCCTCCAAGCTGCCTGAGATTCGTGCAGACC

AACATCAGCAGACTGCTGCAAGAGACAAGCGAGCAGCTGGTGGCCCTGAAGCCT

TGGATCACCAGACAGAACTTCAGCCGGTGCCTGGAACTGCAGTGTGCGGCCGCA

ATTGAAGTTATGTATCCTCCTCCTTACCTAGACAATGAGAAGAGCAATGGAACCA

TTATCCATGTGAAAGGGAAACACCTTTGTCCAAGTCCCCTATTTCCCGGACCTTC

TAAGCCCAAGTTCACCATAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAA

TGTTCCTTCTAATTACCATTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATG ACTTAATAGGCACAGCCTTACAAGTCAAAATGCCCCAGAGTCACAAGGCTATTC

AAGCAGACGGTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCG

CTGGTATGGACCGAAGTATATAACACATTCCATCCGATCCTTCACTCCATCTGTA

GAACAATGCAAGGAAAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCC

AGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTG

ATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGG

TTGATTCACAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCA

TAACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAAC

CTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGG

GAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCA

AGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTG

TCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATG

CCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTA

ATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCA

AAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAA

AAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATACTTT

GAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCG

GAATGATCAGTGGAACTACCACAGAAGCGGAACTGTGGGATGACTGGGCACCAT

ATGAAGACGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGATATA

AGTTTCCTTTATACATGATTGGACATGGTATGTTGGACTCCGATCTTCATCTTAGC

TCAAAGGCTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAACTTC

CTGATGATGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGA

GCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTA

TCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGC

ATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAAC

CGACTTGGAAAG SEQ ID NO: 813

[00854] Construct pJAQ603 [CD8a Signal Peptide]-[CD117 scFv 67 Targeting

Domain]-[CD8 trunc Hinge]-[VSVG TM tail TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGTGCAGCTGGTGGAAAGCGGCGGAGGCCTGGTTCAGCCCGGCG

GAAGCCTGCGGCTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCGACGCCGACA

TGGACTGGGTGCGGCAGGCCCCTGGAAAAGGCCTGGAATGGGTCGGCCGCACCA

GAAACAAGGCCGGCTCTTATACAACCGAGTACGCTGCTTCTGTGAAGGGCAGAT

TCACAATTTCTAGAGATGACAGCAAGAACAGCCTGTACCTGCAAATGAATTCCCT

GAAGACCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCCTAAGTACTGGAT

CGACTTCGACCTGTGGGGCAGAGGCACACTGGTGACAGTGTCCTCCGGCGGAGG

TGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAGATATCCAGATGACCCA

GAGCCCCAGCAGCCTCAGCGCCAGCGTGGGAGATAGAGTGACCATCACATGCAG

AGCCTCCCAGTCTATCAGCAGCTACCTGAACTGGTACCAGCAGAAGCCCGGCAA

AGCCCCTAAGCTGCTGATCTACGCCGCTTCTTCTCTGCAGAGCGGCGTGCCTAGC

CGGTTCAGCGGCAGCGGCAGCGGTACAGACTTTACCCTGACCATCAGCTCCCTGC

AGCCTGAGGATTTCGCCACCTACTATTGTCAGCAAAGCTACATCGCCCCATACAC

CTTTGGCGGCGGAACCAAGGTGGAAATCAAGACTACAACTCCAGCACCCAGACC

CCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCC

TGTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTC

CGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTT

ATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 814

[00855] Construct pJAQ606 [CD8a Signal Peptide]-[CD117 scFv 55 Targeting

Domain]-[CD8 trunc Hinge]-[VSVG TM tail TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAAGTTCAGTTGGTTCAGTCCGGCGCTGAAGTTAAAAAGCCCGGAA

GCAGTGTAAAGGTCTCCTGCAAGGCCAGTGGCGGGACATTCCGAATTTACGCCA

TCTCATGGGTCCGACAGGCTCCAGGACAAGGACTTGAGTGGATGGGTGGTATTA

TACCAGACTTCGGGGTTGCCAATTACGCACAAAAATTCCAGGGACGAGTAACTA

TAACTGCGGATGAATCAACCTCTACGGCTTATATGGAGCTCTCATCCTTGCGGTC

AGAAGACACGGCCGTGTATTATTGTGCAAGGGGCGGACTCGACACCGATGAGTT

TGATCTTTGGGGCAGAGGTACTCTGGTGACTGTTAGTAGCGGGGGTGGAGGCTCT

GGCGGAGGGGGAAGTGGCGGAGGAGGGAGCGACATCCAAATGACTCAATCACC

TAGCTCACTTAGCGCAAGCGTTGGCGACCGCGTCACTATTACCTGTCGCGCGTCA

CAATCTATCAACTCATATCTGAATTGGTATCAACAAAAGCCTGGTAAGGCCCCTA

AGCTTCTTATTTATGCAGCCAGTAGCCTTCAATCCGGCGTCCCAAGTCGATTCTCC

GGGAGTGGAAGTGGTACAGATTTTACCCTGACCATAAGCAGTTTGCAGCCGGAA

GACTTTGCTACCTATTATTGCCAACAGGGGGTCTCCGATATTACTTTCGGGGGAG

GCACCAAAGTGGAAATCAAGACTACAACTCCAGCACCCAGACCCCCTACACCTG

CTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGCCTC

TTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTAT

CCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACAT

AGAGATGAACCGACTTGGAAAG SEQ ID NO: 815 [00856] Construct pJAQ608 [CD133 scFv 1 Targeting Domain]-[CD8 trunc Hinge]- [VSVG TM tail TM]

ATGGCCGAGGTGCAGCTGCTGGAAAGCGGCGGAGGCCTGGTGCAGCCTGGCGGC

AGCCTGAGACTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCTCCTACGCCATGA

GCTGGGTTAGACAGGCCCCTGGCAAGGGCCTCGAGTGGGTCAGCGCCATCAGCA

GAACCGGCGGCGTGACCAGATACGCCGACAGCGTGAAGGGCAGATTCACCATCA

GCCGGGACAACTCAAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGCCG

AGGATACAGCCGTGTACTACTGCGCCAAGCGGACCAGGCGGTTCGACTACTGGT

GCCAGGGCACCCTGGTGACAGTGTCCAGCAGCCCCAGCTCCCTGTCTGCTTCTGT

GGGCGACAGAGTGACCATCACCTGCAGAGCCAGCCAGAGCATCAGCAGCTACCT

GAACTGGTACCAGCAGAAACCTGGAAAAGCCCCTAAGCTGCTGATCTACAGCGC

TTCTGATCTGCAATCCGGCGTGCCATCTAGATTTTCTGGCAGCGGATCTGGAACC

GATTTTACACTGACCATTTCCAGCCTGCAGCCCGAGGACTTCGCCACCTACTATT

GTCAGCAAACAGCTAATTCTCCTAGCACATTCGGCCAGGGAACAAAGGTGGAAA

TCACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCA

GCCCCTGTCACTGCGCCCTGAAGCCTGTATTGCCTCTTTTTTCTTTATCATAGGGT

TAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTA

AAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGA

AAG SEQ ID NO: 816

[00857] Construct pJAQ609 [Nipah G mut trunc TM]-[SCF soluble Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA

AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTGAGGGCATCTGCAGAAATCGGGTGACCAACAAC

GTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACC CTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAG

ATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAAC

ATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGG

ACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTT

TCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAA

CCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGC

GTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAG

CCATTCATGCTGCCTCCTGTGGCCGCC SEQ ID NO: 817

[00858] Construct pJAQ612 [Nipah G mut trunc TM]-[CD117 scFv 2D2 Targeting Domain]

ATGAAGAAAATCAACGAAGGCCTGCTGGACTCCAAGATCCTGAGCGCCTTTAAC

ACCGTGATCGCCCTGCTGGGCAGCATCGTGATCATCGTGATGAACATCATGATCA

TCCAGAACTACACACGGTCCACCGACAACCAGGCTGTGATCAAGGACGCCCTGC

AGGGCATTCAGCAGCAAATCAAGGGCCTGGCTGATAAGATCGGAACAGAGATCG

GTCCAAAGGTGTCCCTGATCGACACCAGCAGCACAATCACTATCCCCGCCAACAT

CGGACTCCTGGGCAGCAAGATCAGCCAGTCTACAGCCAGCATCAATGAGAACGT

GAACGAAAAGTGCAAGTTCACCCTGCCTCCCCTGAAGATCCACGAGTGCAACAT

CAGCTGCCCTAATCCCCTGCCCTTCCGGGAATACAGACCCCAGACCGAGGGCGTC

TCCAACCTGGTGGGTCTGCCTAACAACATCTGTCTGCAGAAGACAAGCAACCAG

ATCCTGAAACCTAAGCTGATCTCCTACACCCTGCCAGTGGTGGGACAGTCCGGCA

CCTGCATCACCGATCCTCTGCTGGCCATGGATGAGGGTTATTTCGCCTACAGCCA

TCTGGAACGAATCGGCTCTTGTAGCAGAGGCGTGTCCAAGCAGCGCATCATTGG

CGTGGGCGAAGTGCTGGACCGGGGCGATGAGGTGCCAAGCCTGTTCATGACCAA

CGTGTGGACCCCTCCTAACCCTAATACCGTGTATCACTGCAGCGCTGTGTATAAC

AACGAGTTCTACTACGTGCTGTGCGCCGTGTCTACAGTGGGCGATCCTATCCTGA

ACAGCACCTACTGGTCCGGCAGCCTGATGATGACAAGACTGGCCGTGAAGCCCA

AAAGCAACGGCGGAGGCTACAACCAGCACCAGCTCGCCCTGAGAAGCATTGAGA AGGGCAGATATGACAAGGTGATGCCTTACGGCCCCAGTGGCATCAAACAGGGAG

ACACACTGTACTTCCCCGCCGTGGGCTTCCTGGTTAGAACAGAATTCAAGTACAA

CGACAGCAACTGTCCCATCACCAAGTGCCAGTACAGCAAGCCTGAGAACTGCAG

ACTGAGCATGGGCATCCGGCCTAATAGCCACTACATCCTTAGAAGCGGACTGCTC

AAATACAACCTGAGCGACGGCGAGAACCCTAAGGTCGTGTTCATCGAGATCTCT

GACCAGAGGCTGTCTATCGGAAGCCCTAGCAAAATCTACGACAGCCTGGGACAA

CCTGTGTTTTACCAGGCCAGCTTCAGCTGGGACACCATGATCAAGTTCGGCGACG

TGCTGACCGTTAATCCTCTGGTCGTGAACTGGCGGAACAACACCGTGATCTCTAG

ACCCGGCCAATCTCAGTGTCCTAGATTCAACACCTGTCCTGCCATCTGCGCCGAG

GGCGTGTACAATGACGCCTTCCTGATCGACAGAATTAACTGGATATCTGCCGGCG

TGTTCCTGGACAGCAATGCCACCGCCGCTAATCCTGTGTTTACAGTGTTCAAAGA

TAATGAAATCCTGTACCGGGCACAACTGGCCAGTGAAGATACAAACGCCCAGAA

AACCATCACCAACTGCTTCCTGCTGAAGAACAAGATCTGGTGCATCAGCCTGGTC

GAGATCTACGATACAGGCGACAACGTGATCAGACCAAAGCTGTTTGCCGTCAAG

ATTCCAGAGCAGTGCACCAGTCAAGTGCAGCTGCAGCAGAGCGACGCCGAGCTG

GTGAAGCCCGGAGCCTCCGTGAAGATCTCCTGCAAGGCTAGCGGCTACACCTTC

ACCGACCATGCCATCCACTGGGTGAAACAGCGGCCTGAGCAGGGCCTGGAATGG

ATCGGATGTATCAGCCCCGGCAACGGCGACATCAAATACAATGAGAAGTTCAAG

GGCAAGGCTACACTGTCTGCCGACAAGAGCAGCAGCACCGCCTACATGCAGCTG

AACAGCCTCACCAGCGAGGACAGCGCCGTTTACTTCTGCAAGCGGTGGGACTAC

TTTGATTATTGGGGACAAGGCACCACCCTGACAGTGAGCTCTGGCGGAGGTGGC

TCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAGATATTGTGATGACCCAGAGC

CACAAGTTCATGAGCACAAGCGTCGGAGATAGAGTGTCTATCACATGCAAAGCT

TCTCAGGACGTGTCCACCACCGTGGCCTGGTATCAGCAGAAACCTGGCCAGTCTC

CTAAGCTGCTGATCTACAGCGCCAGCTACAGATACACAGGCGTGCCAGACAGAT

TCACCGGCTCTGGTAGCGGCACAGACTTCACCTTCACCATCTCTAGCGTGCAGGC

CGAAGATCTGGCCGTGTACTACTGCCAGCAACACTACAGCACCCCTCCTACCTTT GGCGGAGGCACAAAGCTGGAAATCAAG SEQ ID NO: 818

[00859] Construct pJAQ614 [CD8a Signal Peptide]-[CD117 scFv 2D 1 Targeting

Domain]-[CD8 trunc Hinge]-[VSVG TM tail TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGATATTGTGATGACCCAGAGCCATAAGTTCATGAGCACCAGCGTGG

GCGATAGAGTGTCCATCACCTGCAAGGCCTCTCAGGACGTGTCTACAACCGTGGC

CTGGTACCAGCAGAAACCTGGCCAGAGCCCTAAGCTGCTGATCTACTCTGCCAGC

TACAGATATACCGGCGTGCCCGACAGATTCACAGGCAGCGGCTCCGGCACAGAC

TTCACCTTCACCATCAGCAGCGTGCAGGCCGAAGATCTGGCCGTTTACTACTGCC

AGCAACACTACAGCACACCTCCAACATTCGGCGGCGGCACCAAGCTGGAAATCA

AAGGCGGTGGAGGCAGCGGAGGCGGAGGCTCTGGCGGCGGCGGCAGCCAAGTG

CAACTCCAGCAGAGTGATGCCGAGCTGGTGAAGCCTGGAGCTTCTGTGAAGATC

AGCTGCAAAGCTTCTGGCTACACCTTTACCGACCACGCCATCCACTGGGTCAAGC

AGCGGCCCGAGCAGGGCCTGGAATGGATCGGCTGTATCTCCCCTGGAAATGGCG

ACATCAAGTACAACGAGAAGTTTAAGGGCAAGGCTACACTGAGCGCCGACAAAA

GCTCTAGCACCGCCTACATGCAGCTGAACAGCCTGACAAGCGAGGACAGCGCCG

TGTATTTCTGCAAGCGGTGGGACTACTTCGACTACTGGGGCCAGGGAACCACCCT

GACCGTGTCCAGCACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACT

ATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGCCTCTTTTTTCTT

TATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTT

GCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGA

ACCGACTTGGAAAGTAA SEQ ID NO: 819

[00860] Construct pJAQ615 [CD8a Signal Peptide]-[CD117 SRI scFv Targeting

Domain]-[CD8 trunc Hinge]-[VSVG TM tail TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTCAAGTGCAGCTGCAGCAGCCTGGAGCCGAGCTGGTGAAACCTGGCG

CCAGCGTGAAGATGAGCTGCAAGGCCTCCGGTTATACATTCACCTCCTACAACAT

GCACTGGGTCAAACAGACCCCTGGCCAGGGCCTCGAGTGGATCGGCGTGATCTA

CAGCGGCAACGGAGATACCAGCTACAACCAGAAATTCAAGGGCAAGGCCACCCT

GACCGCCGACAAGTCCAGCAGCACCGCCTACATGCAGATCAACAGCCTGACCAG

CGAGGATAGCGCCGTGTACTATTGCGCCAGAGAGCGGGACACCAGATTTGGAAA

TTGGGGCCAAGGCACCCTGGTTACAGTGTCTGCCGCTAAGACCACCGGCGGAGG

TGGCTCTGGAGGCGGTGGATCTGGTGGTGGCGGATCAATCGTGCTGACACAGAG

CCCTGCTTCTCTGGCCGTGTCCCTGGGCCTGCGGGCCACAATTAGCTGTAGAGCC

TCTGAGAGCGTGGACATCTACGGCAATAGCTTCATGCACTGGTACCAGCAAAAG

CCTGGCCAGCCCCCCAAGCTGCTGATCTACCTGGCTAGCAACCTGGAAAGCGGC

GTGCCAGCTAGGTTCAGCGGAAGCGGCTCTAGAACCGACTTCACACTGACCATC

GACCCTGTGGAAGCCGATGACGCCGCCACATACTACTGCCAGCAGAACAACGAG

GACCCCTACACCTTTGGCGGCGGAACAAAGCTGGAAATCAAGACTACAACTCCA

GCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGC

GCCCTGAAGCCTGTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTA

TTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGA

AAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 820

[00861] Construct pJAQ616 [CD8a Signal Peptide]-[CD117 scFv 66 Targeting

Domain]-[CD8 trunc Hinge]-[VSVG TM tail TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAGGTGCAGCTGGTGGAAAGCGGCGGCGGCCTGGTGCAGCCTGGAG

GCAGCCTGAGACTGAGCTGCGCCGCTAGCGGCTTCACCTTTTCTGATCACTACAT

GGATTGGGTGCGGCAGGCCCCAGGAAAAGGCCTGGAATGGGTCGGACGGACCA

GAAACAAGGCCTCTTCTTATACAACCGAGTACGCTGCTTCTGTGAAGGGCAGGTT

CACAATTAGCCGGGACGACAGCAAGAACAGCCTGTACCTGCAGATGAACAGCCT

GAAGACCGAGGATACCGCCGTGTACTATTGCGCCAGAGAGCCTAAATACTGGAT

CGACTTCGACCTGTGGGGCAGAGGCACCCTGGTTACAGTGTCCAGCGGCGGTGG

CGGCAGCGGCGGCGGAGGCAGCGGAGGCGGAGGCAGCGACATCCAGATGACAC

AGAGCCCTAGCAGCCTCTCCGCCAGCGTGGGAGATAGAGTGACAATCACATGTA

GAGCCTCCCAGTCTATCAGCTCTTACCTGAATTGGTACCAGCAAAAGCCCGGCAA

GGCCCCTAAGCTGCTGATCTACGCCGCCAGCAGCCTGCAAAGCGGCGTGCCCAG

CAGATTCTCCGGCTCCGGCTCTGGCACCGACTTCACCCTGACCATCAGCTCCCTG

CAGCCCGAGGACTTTGCCACCTACTACTGCCAGCAGAGCTACATCGCCCCTTACA

CCTTCGGCGGCGGCACCAAGGTGGAAATCAAGACTACAACTCCAGCACCCAGAC

CCCCTACACCTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGC

CTGTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCT

CCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATT

TATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 821

[00862] Construct pJAQ623 [CD133 scFv 2 Targeting Domain]-[CD8 trunc Hinge]- [VSVG TM tail TM]

ATGGACATCGTGCTGAGCCAGAGCCCAGCTATCATGAGCGCCAGCCCTGGCGAG

AAGGTGACCATCAGCTGCAGCGCTAGCTCCAGCGTGTCTTACATGTACTGGTACC

AGCAAAAGCCCGGCTCTTCTCCAAAGCCCTGGATCTACCGGACCTCTAATCTGGC

CTCTGGCGTGCCCGCCAGATTTTCTGGCAGCGGCAGCGGAACCAGCTACAGCCTG

ACAATCAGCAGCATGGAAGCCGAGGATGCCGCTACCTACTACTGCCAGCAGTAC

CACAGCTACCCTCCTACCTTCGGCGCCGGCACAAAGCTGGAACTGAAAAGCTCC

GGCGGTGGAGGCAGCGGAGGCGGCGGCGGCGGAAGCTCTAGAAGCAGCCTGGA

AGTGAAACTGGTGGAAAGCGGCCCTGAGCTGAAGAAGCCTGGAGAAACCGTGA

AGATCTCCTGTAAAGCCAGCGGCTATACATTTACCGATTACAGCATGAAGTGGGT

CAACCAGGCCCCTGGCAAGGGCCTGAAGTGGATGGGCTGGATTAACACCGAGAC

CGGCGAGCCTAGCTACGCCGACGACTTCAAGGGCAGATTCGCCTTCAGCCTCGA

GACATCTGCTAGCACCGCCTACCTGCAGATCAACAACCTGAAGAACGAGGACAC

CGCCACATACTTCTGCGCCACCGACTATGGCGATTACTTCGACTACTGGGGCCAG

GGAACAACACTGACCGTGTCCTCCACTACAACTCCAGCACCCAGACCCCCTACAC

CTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATTGC

CTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGG

TATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 822

[00863] Construct pJAQ633 [VSV-G Signal Peptide] -[CD90 scFv 2 Targeting

Domain] -[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCCA

GGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGCGTACG

CTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACTGGGTT

AAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCAGTGAT

TCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGTCGATA

AATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGATTCTGC

CGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAATACTGG

GGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCGGTGGCGGCAGCGGTGGCGGC

GGCAGCGGCGGTGGTGGCAGCGATATTCAGATGACTCAAACAACATCTAGCCTC

TCCGCTTCCCTGGGCGACCGGGTGACGATTTCTTGCAGAGCCTCCCAGGACATCA

GCAATTATCTTAACTGGTACCAGCAGAAACCAGATGGTACGTTTAAACTCCTGAT

CTACTACACCAGTAGGTTGCACTCTGGAGTCCCCAGCCGCTTCAGTGGCGGCGGA

TCAGGGACAGACTACAGCCTTACCATCAGTAATCTGGAAAAGGAAGACATCGCT

ACCTACTTCTGTCAGCAGGGGAACACCTTGCCCCGGACGTTCGGAGGAGGCACT

CGACTGGAAGTGAAAGGTACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGT

AGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACT

ATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAG

AAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGGTC

SEQ ID NO: 823 [00864] Construct pJAQ634 [VSV-G Signal Peptide] -[CD90 scFv 2 Targeting

Domain]-[SGGSx3.2 Linker]-[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCCA

GGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGCGTACG

CTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACTGGGTT

AAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCAGTGAT

TCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGTCGATA

AATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGATTCTGC

CGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAATACTGG

GGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCGGTGGCGGCAGCGGTGGCGGC

GGCAGCGGCGGTGGTGGCAGCGATATTCAGATGACTCAAACAACATCTAGCCTC

TCCGCTTCCCTGGGCGACCGGGTGACGATTTCTTGCAGAGCCTCCCAGGACATCA

GCAATTATCTTAACTGGTACCAGCAGAAACCAGATGGTACGTTTAAACTCCTGAT

CTACTACACCAGTAGGTTGCACTCTGGAGTCCCCAGCCGCTTCAGTGGCGGCGGA

TCAGGGACAGACTACAGCCTTACCATCAGTAATCTGGAAAAGGAAGACATCGCT

ACCTACTTCTGTCAGCAGGGGAACACCTTGCCCCGGACGTTCGGAGGAGGCACT

CGACTGGAAGTGAAAAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCGGTACCAA

TCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCT

TTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTAT

CCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACAT

AGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 824 [00865] Construct pJAQ635 [VSV-G Signal Peptide] -[CD 133 scFv 1 Targeting

Domain] -[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGC

CGAGGTGCAGCTGCTGGAAAGCGGCGGAGGCCTGGTGCAGCCTGGCGGCAGCCT

GAGACTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCTCCTACGCCATGAGCTGG

GTTAGACAGGCCCCTGGCAAGGGCCTCGAGTGGGTCAGCGCCATCAGCAGAACC

GGCGGCGTGACCAGATACGCCGACAGCGTGAAGGGCAGATTCACCATCAGCCGG

GACAACTCAAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGCCGAGGAT

ACAGCCGTGTACTACTGCGCCAAGCGGACCAGGCGGTTCGACTACTGGTGCCAG

GGCACCCTGGTGACAGTGTCCAGCAGCCCCAGCTCCCTGTCTGCTTCTGTGGGCG

ACAGAGTGACCATCACCTGCAGAGCCAGCCAGAGCATCAGCAGCTACCTGAACT

GGTACCAGCAGAAACCTGGAAAAGCCCCTAAGCTGCTGATCTACAGCGCTTCTG

ATCTGCAATCCGGCGTGCCATCTAGATTTTCTGGCAGCGGATCTGGAACCGATTT

TACACTGACCATTTCCAGCCTGCAGCCCGAGGACTTCGCCACCTACTATTGTCAG

CAAACAGCTAATTCTCCTAGCACATTCGGCCAGGGAACAAAGGTGGAAATCGGT

ACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTG

CCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTG

GTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAG

ACATAGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 825

[00866] Construct pJAQ636 [VSV-G Signal Peptide] -[CD 133 scFv 1 Targeting

Domain]-[SGGSx3.2 Linker]-[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGC

CGAGGTGCAGCTGCTGGAAAGCGGCGGAGGCCTGGTGCAGCCTGGCGGCAGCCT

GAGACTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCTCCTACGCCATGAGCTGG

GTTAGACAGGCCCCTGGCAAGGGCCTCGAGTGGGTCAGCGCCATCAGCAGAACC

GGCGGCGTGACCAGATACGCCGACAGCGTGAAGGGCAGATTCACCATCAGCCGG

GACAACTCAAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGCCGAGGAT

ACAGCCGTGTACTACTGCGCCAAGCGGACCAGGCGGTTCGACTACTGGTGCCAG

GGCACCCTGGTGACAGTGTCCAGCAGCCCCAGCTCCCTGTCTGCTTCTGTGGGCG

ACAGAGTGACCATCACCTGCAGAGCCAGCCAGAGCATCAGCAGCTACCTGAACT

GGTACCAGCAGAAACCTGGAAAAGCCCCTAAGCTGCTGATCTACAGCGCTTCTG

ATCTGCAATCCGGCGTGCCATCTAGATTTTCTGGCAGCGGATCTGGAACCGATTT

TACACTGACCATTTCCAGCCTGCAGCCCGAGGACTTCGCCACCTACTATTGTCAG

CAAACAGCTAATTCTCCTAGCACATTCGGCCAGGGAACAAAGGTGGAAATCAGC

GGTGGGAGCGGCGGGAGCGGTGGGAGCGGTACCAATCCAATCGAGCTTGTAGAA

GGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTT

AATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAA

AGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAA

AGGTC SEQ ID NO: 826

[00867] Construct pJAQ637 [VSV-G Signal Peptide] -[CD 133 scFv 2 Targeting

Domain] -[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

CATCGTGCTGAGCCAGAGCCCAGCTATCATGAGCGCCAGCCCTGGCGAGAAGGT

GACCATCAGCTGCAGCGCTAGCTCCAGCGTGTCTTACATGTACTGGTACCAGCAA

AAGCCCGGCTCTTCTCCAAAGCCCTGGATCTACCGGACCTCTAATCTGGCCTCTG

GCGTGCCCGCCAGATTTTCTGGCAGCGGCAGCGGAACCAGCTACAGCCTGACAA TCAGCAGCATGGAAGCCGAGGATGCCGCTACCTACTACTGCCAGCAGTACCACA

GCTACCCTCCTACCTTCGGCGCCGGCACAAAGCTGGAACTGAAAAGCTCCGGCG

GTGGAGGCAGCGGAGGCGGCGGCGGCGGAAGCTCTAGAAGCAGCCTGGAAGTG

AAACTGGTGGAAAGCGGCCCTGAGCTGAAGAAGCCTGGAGAAACCGTGAAGAT

CTCCTGTAAAGCCAGCGGCTATACATTTACCGATTACAGCATGAAGTGGGTCAAC

CAGGCCCCTGGCAAGGGCCTGAAGTGGATGGGCTGGATTAACACCGAGACCGGC

GAGCCTAGCTACGCCGACGACTTCAAGGGCAGATTCGCCTTCAGCCTCGAGACA

TCTGCTAGCACCGCCTACCTGCAGATCAACAACCTGAAGAACGAGGACACCGCC

ACATACTTCTGCGCCACCGACTATGGCGATTACTTCGACTACTGGGGCCAGGGAA

CAACACTGACCGTGTCCTCCGGTACCAATCCAATCGAGCTTGTAGAAGGTTGGTT

CAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTG

GACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACC

AAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGGTC

SEQ ID NO: 827

[00868] Construct pJAQ638 [VSV-G Signal Peptide] -[CD 133 scFv 2 Targeting

Domain]-[SGGSx3.2 Linker]-[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

CATCGTGCTGAGCCAGAGCCCAGCTATCATGAGCGCCAGCCCTGGCGAGAAGGT

GACCATCAGCTGCAGCGCTAGCTCCAGCGTGTCTTACATGTACTGGTACCAGCAA

AAGCCCGGCTCTTCTCCAAAGCCCTGGATCTACCGGACCTCTAATCTGGCCTCTG

GCGTGCCCGCCAGATTTTCTGGCAGCGGCAGCGGAACCAGCTACAGCCTGACAA

TCAGCAGCATGGAAGCCGAGGATGCCGCTACCTACTACTGCCAGCAGTACCACA

GCTACCCTCCTACCTTCGGCGCCGGCACAAAGCTGGAACTGAAAAGCTCCGGCG

GTGGAGGCAGCGGAGGCGGCGGCGGCGGAAGCTCTAGAAGCAGCCTGGAAGTG

AAACTGGTGGAAAGCGGCCCTGAGCTGAAGAAGCCTGGAGAAACCGTGAAGAT CTCCTGTAAAGCCAGCGGCTATACATTTACCGATTACAGCATGAAGTGGGTCAAC

CAGGCCCCTGGCAAGGGCCTGAAGTGGATGGGCTGGATTAACACCGAGACCGGC

GAGCCTAGCTACGCCGACGACTTCAAGGGCAGATTCGCCTTCAGCCTCGAGACA

TCTGCTAGCACCGCCTACCTGCAGATCAACAACCTGAAGAACGAGGACACCGCC

ACATACTTCTGCGCCACCGACTATGGCGATTACTTCGACTACTGGGGCCAGGGAA

CAACACTGACCGTGTCCTCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCGGTA

CCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGC

CTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGG

TATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 828

[00869] Construct pJAQ639 [VSV-G Signal Peptide] -[CXCL 12 Targeting Domain]-

[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCAA

CGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCAGCGAC

GGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGAAAGCCAT

GTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCAAACTGTGCCC

TTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGCATTGACCCGA

AGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAGGGTACCAATC

CAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTT

TTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCC

ATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAG

AGATGAACCGACTTGGAAAGGTC SEQ ID NO: 829

[00870] Construct pJAQ640 [VSV-G Signal Peptide] -[CXCL 12 Targeting Domain]-

[SGGSx3.2 Linker] -[ VS VGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCAA

CGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCAGCGAC

GGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGAAAGCCAT

GTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCAAACTGTGCCC

TTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGCATTGACCCGA

AGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAGAGCGGTGGGA

GCGGCGGGAGCGGTGGGAGCGGTACCAATCCAATCGAGCTTGTAGAAGGTTGGT

TCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATT

GGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACAC

CAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGGTC

SEQ ID NO: 830

[00871] Construct pJAQ641 [VSV-G Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain]-[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCAC

CAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTACGAGGACGA

GAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCTAATGGCTTT

ACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTCTCACCACCA

CAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGGACGACACCG

ACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCAAGAACAACC ACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAACAACAAGCTGT

GCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATCTGTATCAAGG

ACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATTGCCAGATCGT

GGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGGTTAAGAACGG

AGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATACAGTGAACCA

GATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTCGACTCCAGT

GGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAAAACAAGAGC

AGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATGCCTAGCACC

ACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTACATCCACGGC

ATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGAACATTAGCA

TCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCATCCAGTTCG

AGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCACACTGACCA

CATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACGGTACCAATCCAAT

CGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCT

TTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTT

TGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATG

AACCGACTTGGAAAGGTC SEQ ID NO: 831

[00872] Construct pJAQ642 [VSV-G Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain]-[SGGSx3.2 Linker]-[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCAC

CAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTACGAGGACGA

GAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCTAATGGCTTT

ACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTCTCACCACCA

CAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGGACGACACCG ACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCAAGAACAACC

ACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAACAACAAGCTGT

GCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATCTGTATCAAGG

ACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATTGCCAGATCGT

GGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGGTTAAGAACGG

AGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATACAGTGAACCA

GATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTCGACTCCAGT

GGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAAAACAAGAGC

AGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATGCCTAGCACC

ACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTACATCCACGGC

ATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGAACATTAGCA

TCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCATCCAGTTCG

AGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCACACTGACCA

CATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACAGCGGTGGGAGCGG

CGGGAGCGGTGGGAGCGGTACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAG

TAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGAC

TATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAG

AAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGGTC

SEQ ID NO: 832

[00873] Construct pJAQ643 [VSV-G Signal Peptide]-[SCF full Targeting Domain]- [VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCAA

AAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAAC

CCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAG

GACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAG

TACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTG GTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTG

AAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACC

TGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGA

GCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAG

TATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTC

AGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTC

ATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATA

GAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCC

TGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAG

AAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGA

AGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGG

GTACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTAT

TGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGT

TGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACA

GACATAGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 833

[00874] Construct pJAQ644 [VSV-G Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.2 Linker] -[ VS VGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCAA

AAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAAC

CCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAG

GACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAG

TACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTG

GTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTG

AAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACC

TGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGA GCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAG

TATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTC

AGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTC

ATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATA

GAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCC

TGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAG

AAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGA

AGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGA

GCGGTGGGAGCGGCGGGAGCGGTGGGAGCGGTACCAATCCAATCGAGCTTGTAG

AAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGG

TTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATT

AAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGG

AAAGGTC SEQ ID NO: 834

[00875] Construct pJAQ645 [VSV-G Signal Peptide]-[SCF soluble Targeting

Domain] -[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

GGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGT

GGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGA

CGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCT

CTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACA

GCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAG

AGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGT

TCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGA

CTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCT

GAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCC

GCCGGTACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGC TCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTC

CGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTT

ATACAGACATAGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 835

[00876] Construct pJAQ646 [VSV-G Signal Peptide]-[SCF soluble Targeting

Domain]-[SGGSx3.2 Linker]-[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

GGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGT

GGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGA

CGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGGTGGTGCAGCTGAGCGATTCT

CTGACAGATCTGCTGGACAAGTTCAGCAACATTTCTGAAGGCCTGAGCAATTACA

GCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAAG

AGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTGT

TCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGGA

CTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCCT

GAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCC

GCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCGGTACCAATCCAATCGAGCTT

GTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCAT

AGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTA

AATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGAC

TTGGAAAGGTC SEQ ID NO: 836

[00877] Construct pJAQ647 [VSV-G Signal Peptide]-[SCF mutant (V49L/F63L)

Targeting Domain]- [VS VGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCAA

AAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAAC

CCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAG

GACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAG

TACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGG

TGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGA

AGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCT

GGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAG

CCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGT

ATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCA

GCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCA

TGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAG

AAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCT

GCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAG

AAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGA

AGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGG

GTACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTAT

TGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGT

TGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACA

GACATAGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 837

[00878] Construct pJAQ648 [VSV-G Signal Peptide]-[SCF mutant (V49L/F63L)

Targeting Domain] -[SGGSx3.2 Einker] -[ VS VGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCAA

AAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAAC

CCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAG

GACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAG

TACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGG

TGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGA

AGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCT

GGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAG

CCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGT

ATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCA

GCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCA

TGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAG

AAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCT

GCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAG

AAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGA

AGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGA

GCGGTGGGAGCGGCGGGAGCGGTGGGAGCGGTACCAATCCAATCGAGCTTGTAG

AAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGG

TTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATT

AAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGG

AAAGGTC SEQ ID NO: 838

[00879] Construct pJAQ649 [VSV-G Signal Peptide]-[SCF soluble mutant

(V49L/F63L) Targeting Domain]-[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

GGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGT

GGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGA

CGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGCGATTCT

CTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCAATTAC

AGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAA

GAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTG

TTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGG

ACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCC

TGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCC

GCCGGTACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGC

TCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTC

CGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTT

ATACAGACATAGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 839

[00880] Construct pJAQ650 [VSV-G Signal Peptide]-[SCF soluble mutant

(V49L/F63L) Targeting Domain]-[SGGSx3.2 Einker] -[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

GGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGT

GGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGA

CGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGCGATTCT

CTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCAATTAC

AGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGAAA

GAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTG TTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGG

ACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCC

TGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCC

GCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCGGTACCAATCCAATCGAGCTT

GTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCAT

AGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTA

AATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGAC

TTGGAAAGGTC SEQ ID NO: 840

[00881] Construct pJAQ651 [VSV-G Signal Peptide]-[SCF mutant (V49L/F63L/K91E) Targeting Domain] -[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCAA

AAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAAC

CCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAG

GACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAG

TACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGG

TGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGA

AGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCT

GGTTGAGTGCGTGGAGGAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAG

CCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGT

ATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCA

GCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCA

TGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAG

AAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCT

GCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAG

AAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGA AGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGG

GTACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTAT

TGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGT

TGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACA

GACATAGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 841

[00882] Construct pJAQ652 [VSV-G Signal Peptide]-[SCF soluble mutant (V49L/F63L/K91E) Targeting Domain] -[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

GGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGT

GGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGA

CGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGCGATTCT

CTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCAATTAC

AGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGGAG

GAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTG

TTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGG

ACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCC

TGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCC

GCCGGTACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGC

TCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTC

CGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTT

ATACAGACATAGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 842

[00883] Construct pJAQ653 [VSV-G Signal Peptide]-[SCF soluble mutant

(V49L/F63L/K91E) Targeting Domain]-[SGGSx3.2 Linker]-[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

GGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGT

GGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGA

CGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGCGATTCT

CTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCAATTAC

AGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGGAG

GAGAACAGCTCCAAGGACCTGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTG

TTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGG

ACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCC

TGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCC

GCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCGGTACCAATCCAATCGAGCTT

GTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCAT

AGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTA

AATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGAC

TTGGAAAGGTC SEQ ID NO: 843

[00884] Construct pJAQ654 [VSV-G Signal Peptide]-[SCF mutant

(V49L/F63L/K91E/I98R) Targeting Domain]-[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCAA

AAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAAC

CCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAG

GACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAG

TACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGG

TGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGA

AGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCT

GGTTGAGTGCGTGGAGGAGAACAGCTCCAAGGACCGGAAAAAGTCTTTCAAGAG

CCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGT

ATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCA

GCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCA

TGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAG

AAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCT

GCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAG

AAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGA

AGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGG

GTACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTAT

TGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGT

TGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACA

GACATAGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 844

[00885] Construct pJAQ655 [VSV-G Signal Peptide]-[SCF mutant

(V49L/F63L/K91E/I98R) Targeting Domain]-[SGGSx3.2 Einker] -[ VS VGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCAA

AAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCTGTTTAAC CCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAG

GACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCACCCTGAAG

TACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGG

TGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGA

AGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTGGACGACCT

GGTTGAGTGCGTGGAGGAGAACAGCTCCAAGGACCGGAAAAAGTCTTTCAAGAG

CCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGT

ATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCA

GCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCA

TGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGCTCTAATAG

AAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCTATGGCCCT

GCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTATTGGAAG

AAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAACGAGGA

AGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGGAGGTGA

GCGGTGGGAGCGGCGGGAGCGGTGGGAGCGGTACCAATCCAATCGAGCTTGTAG

AAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGG

TTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATT

AAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGG

AAAGGTC SEQ ID NO: 845

[00886] Construct pJAQ656 [VSV-G Signal Peptide]-[SCF soluble mutant

(V49L/F63L/K91E/I98R) Targeting Domain]-[SGGSx3.2 Einker] -[ VS VGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

GGGCATCTGCAGAAATCGGGTGACCAACAACGTGAAGGACGTGACAAAGCTGGT

GGCTAATCTGCCCAAGGACTACATGATCACCCTGAAGTACGTGCCTGGCATGGA CGTGCTGCCCAGCCACTGTTGGATCAGCGAGATGCTGGTGCAGCTGAGCGATTCT

CTGACAGATCTGCTGGACAAGCTGAGCAACATTTCTGAAGGCCTGAGCAATTAC

AGCATCATCGACAAGCTGGTCAACATCGTGGACGACCTGGTTGAGTGCGTGGAG

GAGAACAGCTCCAAGGACCGGAAAAAGTCTTTCAAGAGCCCCGAGCCAAGACTG

TTCACCCCTGAGGAATTCTTCAGAATCTTCAACCGGAGTATCGACGCCTTTAAGG

ACTTCGTGGTGGCCTCTGAGACATCTGATTGCGTGGTCAGCAGCACCCTGTCCCC

TGAAAAGGATAGCAGAGTGTCCGTGACCAAGCCATTCATGCTGCCTCCTGTGGCC

GCCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCGGTACCAATCCAATCGAGCTT

GTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCAT

AGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTA

AATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGAC

TTGGAAAGGTC SEQ ID NO: 846

[00887] Construct pJAQ659 [VSV-G Signal Peptide] -[TPO- 171 Targeting Domain] -

[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

GCTGACCGAGCTGCTGCTGGTCGTTATGCTGCTGCTTACAGCCAGACTGACACTG

TCCAGCCCTGCCCCTCCAGCATGCGACCTGAGGGTGCTGAGCAAGCTGCTGAGA

GATAGCCACGTGCTGCACTCTAGACTGTCTCAGTGCCCCGAGGTGCACCCTCTGC

CCACCCCTGTGCTGCTCCCCGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCA

GATGGAAGAAACCAAGGCCCAGGATATCCTGGGCGCTGTGACCCTGCTGCTGGA

AGGCGTGATGGCCGCTAGAGGACAACTGGGACCTACCTGTCTGAGCAGCCTGCT

GGGCCAGCTGTCCGGCCAAGTGCGGCTGCTGCTGGGCGCCCTGCAGAGCCTGCT

CGGCACACAGCTGCCTCCTCAGGGCAGAACCACCGCCCATAAGGACCCCAACGC

CATCTTCCTGAGCTTTCAGCACCTGCTGCGGGGCAAAGTGCGGTTCCTGATGCTG

GTGGGCGGATCTACACTGGGTACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCA

GTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGA CTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAA

GAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGGTC

SEQ ID NO: 847

[00888] Construct pJAQ660 [VSV-G Signal Peptide]- [CD 117 scFv 54 Targeting

Domain] -[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCCA

AGTCCAGCTGGTGCAAAGTGGAGCAGAAGTCAAGAAACCCGGAAGCTCAGTCAA

AGTGTCTTGCAAAGCTAGCGGAGGCACGTTCTCAAGTTATGCCATATCCTGGGTG

CGCCAAGCGCCCGGCCAAGGCTTGGAATGGATGGGTGGTATAATACCGATTTTT

GGGACAGCGAATTATGCACAGAAGTTTCAAGGTAGAGTGACGATTACGGCGGAT

GAAAGTACATCCACGGCGTACATGGAGCTGTCCAGTCTGCGGTCAGAAGACACA

GCCGTATATTACTGCGCGCGAGGAGGGCTCGATACGGACGAATTTGATCTGTGG

GGGCGGGGGACCTTGGTCACAGTAAGTAGCGGGGGAGGAGGCTCTGGCGGTGGC

GGTTCAGGTGGAGGAGGATCCGACATTCAGATGACTCAATCCCCTTCCTCCCTGA

GTGCCTCCGTCGGGGACAGAGTAACGATTACCTGTAGGGCCAGCCAAAGTATTA

ACAGCTACCTGAATTGGTATCAGCAGAAGCCCGGCAAAGCCCCGAAGCTCTTGA

TATACGCCGCGTCCTCCTTGCAAAGTGGGGTGCCGTCTAGATTCAGCGGTAGCGG

TAGTGGAACGGATTTTACGCTTACTATATCTAGTCTTCAACCGGAGGATTTTGCT

ACTTATTATTGTCAACAAGGAGTGTCCGATATCACGTTTGGCGGTGGGACAAAGG

TGGAAATTAAAGGTACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTG

GAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCT

TGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAG

ACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 848 [00889] Construct pJAQ661 [VSV-G Signal Peptide]- [CD 117 scFv 57 Targeting

Domain]-[SGGSx3.2 Linker]-[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCCA

AGTCCAACTTGTACAATCTGGTGCGGAGGTCAAGAAACCGGGTAGCTCCGTTAA

GGTCTCATGCAAAGCAAGCGGTGGCACTTTCAGTTTGTATGCGATCTCTTGGGTG

CGGCAAGCGCCAGGACAAGGTCTGGAATGGATGGGTGGGATAATACCTCATTTT

GGACTCGCGAATTATGCACAAAAGTTTCAAGGTAGAGTTACAATAACCGCGGAT

GAAAGTACCTCCACCGCATACATGGAGTTGTCAAGCCTTAGGAGTGAGGACACA

GCCGTTTATTACTGTGCCCGAGGCGGATTGGACACTGATGAATTTGACTTGTGGG

GGAGAGGCACACTCGTAACAGTCAGTAGTGGGGGAGGCGGCTCCGGAGGCGGC

GGTTCTGGCGGCGGAGGTTCCGATATTCAAATGACCCAGAGTCCAAGTAGTCTTT

CCGCATCCGTAGGTGACAGAGTGACTATAACATGCAGGGCATCACAATCCATCA

ACTCTTATCTGAACTGGTACCAACAAAAACCAGGTAAAGCTCCTAAGCTGCTCAT

ATATGCAGCAAGTTCCCTCCAGAGCGGAGTCCCCTCTCGGTTTTCTGGTTCCGGA

AGCGGAACAGATTTTACGCTCACTATAAGTAGCCTTCAACCTGAGGACTTCGCAA

CATATTACTGTCAACAAGGCGTTTCTGACATCACCTTCGGGGGCGGCACCAAGGT

CGAGATAAAAAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCGGTACCAATCCAA

TCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTC

TTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCT

TTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGAT

GAACCGACTTGGAAAGGTC SEQ ID NO: 849

[00890] Construct pJAQ662 [VSV-G Signal Peptide]- [CD 117 scFv 67 Targeting

Domain]-[SGGSx3.2 Linker]-[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

GGTGCAGCTGGTGGAAAGCGGCGGAGGCCTGGTTCAGCCCGGCGGAAGCCTGCG

GCTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCGACGCCGACATGGACTGGGT

GCGGCAGGCCCCTGGAAAAGGCCTGGAATGGGTCGGCCGCACCAGAAACAAGG

CCGGCTCTTATACAACCGAGTACGCTGCTTCTGTGAAGGGCAGATTCACAATTTC

TAGAGATGACAGCAAGAACAGCCTGTACCTGCAAATGAATTCCCTGAAGACCGA

GGACACCGCCGTGTACTACTGCGCCAGAGAGCCTAAGTACTGGATCGACTTCGA

CCTGTGGGGCAGAGGCACACTGGTGACAGTGTCCTCCGGCGGAGGTGGCTCTGG

AGGCGGTGGATCTGGTGGTGGCGGATCAGATATCCAGATGACCCAGAGCCCCAG

CAGCCTCAGCGCCAGCGTGGGAGATAGAGTGACCATCACATGCAGAGCCTCCCA

GTCTATCAGCAGCTACCTGAACTGGTACCAGCAGAAGCCCGGCAAAGCCCCTAA

GCTGCTGATCTACGCCGCTTCTTCTCTGCAGAGCGGCGTGCCTAGCCGGTTCAGC

GGCAGCGGCAGCGGTACAGACTTTACCCTGACCATCAGCTCCCTGCAGCCTGAG

GATTTCGCCACCTACTATTGTCAGCAAAGCTACATCGCCCCATACACCTTTGGCG

GCGGAACCAAGGTGGAAATCAAGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGC

GGTACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTA

TTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAG

TTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATAC

AGACATAGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 850

[00891] Construct pJAQ664 [VSV-G Signal Peptide]-[TPO-157 Targeting Domain]-

[SGGSx3.2 Linker] -[ VS VGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

ACTGACCGAGCTGCTGCTGGTCGTGATGCTGCTGCTCACCGCCAGACTGACCCTG

AGCAGCCCCGCCCCTCCTGCCTGCGATCTGCGGGTGCTGTCTAAACTGCTGCGGG

ACAGCCACGTGCTGCATTCTAGACTGAGCCAGTGTCCTGAGGTGCACCCCCTGCC

CACCCCTGTGCTGCTGCCCGCTGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAA

ATGGAAGAGACAAAGGCCCAAGACATCCTGGGCGCCGTGACCCTGCTGCTGGAA

GGCGTGATGGCCGCTAGAGGCCAGCTGGGCCCTACATGCCTGTCCAGCCTCCTGG

GACAGCTGTCCGGCCAGGTGCGGCTGCTGCTTGGAGCCCTGCAGAGCCTGCTGG

GCACACAGCTGCCACCTCAGGGCAGAACCACAGCCCACAAGGATCCTAACGCCA

TCTTCCTGAGCTTTCAGCACCTGCTGAGAAGCGGTGGGAGCGGCGGGAGCGGTG

GGAGCGGTACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAA

GCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTC

TCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGAT

TTATACAGACATAGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 851

[00892] Construct pJAQ665 [VSV-G Signal Peptide] -[TPO- 163 Targeting Domain]-

[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

ACTGACCGAGCTGCTGCTGGTCGTGATGCTGCTGCTCACAGCCCGCCTGACACTG

AGCAGCCCTGCCCCTCCAGCCTGCGATCTGAGAGTGCTGAGCAAACTGCTGAGA

GATAGCCACGTGCTGCACAGCAGACTGTCTCAGTGCCCCGAGGTGCACCCCCTGC

CCACCCCTGTGCTGCTGCCTGCCGTGGACTTCAGCCTGGGAGAGTGGAAGACCCA

AATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCTGCTGCTGGA

AGGCGTGATGGCCGCTAGAGGCCAGCTGGGACCTACCTGTCTGTCCAGCCTGCTT

GGCCAGCTCTCCGGCCAAGTGCGGCTGCTGCTGGGAGCTCTGCAGAGCCTGCTG

GGCACACAGCTGCCTCCTCAGGGCAGAACCACCGCCCATAAGGACCCCAACGCC

ATCTTCCTGTCTTTTCAGCACCTGCTGCGGGGCAAGGTGCGGTTCCTGGGTACCA ATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTC

_{TTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTAT}

CCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACAT

AGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 852

[00893] Construct pJAQ666 [VSV-G Signal Peptide]- [CD 117 scFv 55 Targeting

Domain]-[SGGSx3.2 Linker]-[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCCA

AGTTCAGTTGGTTCAGTCCGGCGCTGAAGTTAAAAAGCCCGGAAGCAGTGTAAA

GGTCTCCTGCAAGGCCAGTGGCGGGACATTCCGAATTTACGCCATCTCATGGGTC

CGACAGGCTCCAGGACAAGGACTTGAGTGGATGGGTGGTATTATACCAGACTTC

GGGGTTGCCAATTACGCACAAAAATTCCAGGGACGAGTAACTATAACTGCGGAT

GAATCAACCTCTACGGCTTATATGGAGCTCTCATCCTTGCGGTCAGAAGACACGG

CCGTGTATTATTGTGCAAGGGGCGGACTCGACACCGATGAGTTTGATCTTTGGGG

CAGAGGTACTCTGGTGACTGTTAGTAGCGGGGGTGGAGGCTCTGGCGGAGGGGG

AAGTGGCGGAGGAGGGAGCGACATCCAAATGACTCAATCACCTAGCTCACTTAG

CGCAAGCGTTGGCGACCGCGTCACTATTACCTGTCGCGCGTCACAATCTATCAAC

TCATATCTGAATTGGTATCAACAAAAGCCTGGTAAGGCCCCTAAGCTTCTTATTT

ATGCAGCCAGTAGCCTTCAATCCGGCGTCCCAAGTCGATTCTCCGGGAGTGGAA

GTGGTACAGATTTTACCCTGACCATAAGCAGTTTGCAGCCGGAAGACTTTGCTAC

CTATTATTGCCAACAGGGGGTCTCCGATATTACTTTCGGGGGAGGCACCAAAGTG

GAAATCAAGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCGGTACCAATCCAAT

CGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCT

TTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTT

TGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATG

AACCGACTTGGAAAGGTC SEQ ID NO: 945 [00894] Construct pJAQ683 [VSV-G Signal Peptide]- [CD 117 scFv 4k94 Targeting Domain]-[VSVG TM tail TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTGAGGT

GCAGCTGGTCGAGAGCGGAGGCGGCCTGGTGCAGCCAGGCGGATCTCTGAGACT

GAGCTGCGCCGCCTCTGGCTTCAATATCAGCAGCTACAGCATGCACTGGGTGCGG

CAGGCCCCTGGCAAAGGCCTGGAATGGGTCGCCAGCATCTATCCTTACAGCGGC

TACACCTACTACGCCGACAGCGTGAAGGGCAGATTCACAATTAGCGCCGATACC

AGCAAGAACACCGCTTACCTGCAGATGAACAGCCTGCGGGCCGAGGACACCGCC

GTGTACTACTGCGCCAGATACGTGTACCACGCCCTGGACTACTGGGGCCAGGGC

ACACTGGTGACCGTGTCCAGCGGCGGCGGCGGATCTGGAGGCGGCGGTTCCGGA

GGAGGCGGCAGCGACATCCAGATGACCCAGTCTCCTAGCTCCCTGTCTGCTAGCG

TGGGCGACAGGGTGACCATCACCTGTAGAGCCAGCCAGAGCGTGTCTAGCGCTG

TTGCTTGGTATCAGCAAAAACCTGGCAAGGCCCCTAAGCTGCTGATCTACTCCGC

CAGTTCTCTGTACTCCGGCGTGCCCAGCCGGTTCAGCGGCTCTAGAAGCGGAACA

GATTTTACCCTGACCATCAGCAGCCTCCAGCCCGAGGATTTCGCCACATACTATT

GCCAGCAGTGGGCCGTGCACAGCCTGATCACATTCGGCCAAGGCACCAAGGTGG

AAATCAAGACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAA

GCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTC

TCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGAT

TTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 853

[00895] Construct pJAQ737 [VSV-G Signal Peptide]-[TPO-157 Targeting Domain]-

[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

ACTGACCGAGCTGCTGCTGGTCGTGATGCTGCTGCTCACCGCCAGACTGACCCTG

AGCAGCCCCGCCCCTCCTGCCTGCGATCTGCGGGTGCTGTCTAAACTGCTGCGGG

ACAGCCACGTGCTGCATTCTAGACTGAGCCAGTGTCCTGAGGTGCACCCCCTGCC

CACCCCTGTGCTGCTGCCCGCTGTGGACTTCAGCCTGGGCGAGTGGAAGACCCAA

ATGGAAGAGACAAAGGCCCAAGACATCCTGGGCGCCGTGACCCTGCTGCTGGAA

GGCGTGATGGCCGCTAGAGGCCAGCTGGGCCCTACATGCCTGTCCAGCCTCCTGG

GACAGCTGTCCGGCCAGGTGCGGCTGCTGCTTGGAGCCCTGCAGAGCCTGCTGG

GCACACAGCTGCCACCTCAGGGCAGAACCACAGCCCACAAGGATCCTAACGCCA

TCTTCCTGAGCTTTCAGCACCTGCTGAGAGGTACCAATCCAATCGAGCTTGTAGA

AGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGT

TAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTA

AAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGA

AAGGTC SEQ ID NO: 854

[00896] Construct pJAQ738 [VSV-G Signal Peptide] -[TPO- 163 Targeting Domain]-

[SGGSx3.2 Linker] -[ VS VGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

GCTGACCGAGCTGCTGCTGGTCGTTATGCTGCTGCTTACAGCCAGACTGACACTG

TCCAGCCCTGCCCCTCCAGCATGCGACCTGAGGGTGCTGAGCAAGCTGCTGAGA

GATAGCCACGTGCTGCACTCTAGACTGTCTCAGTGCCCCGAGGTGCACCCTCTGC

CCACCCCTGTGCTGCTCCCCGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCA GATGGAAGAAACCAAGGCCCAGGATATCCTGGGCGCTGTGACCCTGCTGCTGGA

AGGCGTGATGGCCGCTAGAGGACAACTGGGACCTACCTGTCTGAGCAGCCTGCT

GGGCCAGCTGTCCGGCCAAGTGCGGCTGCTGCTGGGCGCCCTGCAGAGCCTGCT

CGGCACACAGCTGCCTCCTCAGGGCAGAACCACCGCCCATAAGGACCCCAACGC

CATCTTCCTGAGCTTTCAGCACCTGCTGCGGGGCAAAGTGCGGTTCCTGAGCGGT

GGGAGCGGCGGGAGCGGTGGGAGCGGTACCAATCCAATCGAGCTTGTAGAAGGT

TGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAAT

CATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGC

ACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAG

GTC SEQ ID NO: 855

[00897] Construct pJAQ739 [VSV-G Signal Peptide] -[TPO- 171 Targeting Domain] - [SGGSx3.2 Linker] -[ VS VGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

GCTGACCGAGCTGCTGCTGGTCGTTATGCTGCTGCTTACAGCCAGACTGACACTG

TCCAGCCCTGCCCCTCCAGCATGCGACCTGAGGGTGCTGAGCAAGCTGCTGAGA

GATAGCCACGTGCTGCACTCTAGACTGTCTCAGTGCCCCGAGGTGCACCCTCTGC

CCACCCCTGTGCTGCTCCCCGCCGTGGACTTCAGCCTGGGCGAGTGGAAGACCCA

GATGGAAGAAACCAAGGCCCAGGATATCCTGGGCGCTGTGACCCTGCTGCTGGA

AGGCGTGATGGCCGCTAGAGGACAACTGGGACCTACCTGTCTGAGCAGCCTGCT

GGGCCAGCTGTCCGGCCAAGTGCGGCTGCTGCTGGGCGCCCTGCAGAGCCTGCT

CGGCACACAGCTGCCTCCTCAGGGCAGAACCACCGCCCATAAGGACCCCAACGC

CATCTTCCTGAGCTTTCAGCACCTGCTGCGGGGCAAAGTGCGGTTCCTGATGCTG

GTGGGCGGATCTACACTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCGGTAC

CAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCC

TCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGT ATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGAC

ATAGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 856

[00898] Construct pJAQ740 [VSV-G Signal Peptide]- [CD 117 scFv 2D1 Targeting

Domain]-[SGGSx3.2 Linker]-[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

TATTGTGATGACCCAGAGCCATAAGTTCATGAGCACCAGCGTGGGCGATAGAGT

GTCCATCACCTGCAAGGCCTCTCAGGACGTGTCTACAACCGTGGCCTGGTACCAG

CAGAAACCTGGCCAGAGCCCTAAGCTGCTGATCTACTCTGCCAGCTACAGATATA

CCGGCGTGCCCGACAGATTCACAGGCAGCGGCTCCGGCACAGACTTCACCTTCA

CCATCAGCAGCGTGCAGGCCGAAGATCTGGCCGTTTACTACTGCCAGCAACACT

ACAGCACACCTCCAACATTCGGCGGCGGCACCAAGCTGGAAATCAAAGGCGGTG

GAGGCAGCGGAGGCGGAGGCTCTGGCGGCGGCGGCAGCCAAGTGCAACTCCAG

CAGAGTGATGCCGAGCTGGTGAAGCCTGGAGCTTCTGTGAAGATCAGCTGCAAA

GCTTCTGGCTACACCTTTACCGACCACGCCATCCACTGGGTCAAGCAGCGGCCCG

AGCAGGGCCTGGAATGGATCGGCTGTATCTCCCCTGGAAATGGCGACATCAAGT

ACAACGAGAAGTTTAAGGGCAAGGCTACACTGAGCGCCGACAAAAGCTCTAGCA

CCGCCTACATGCAGCTGAACAGCCTGACAAGCGAGGACAGCGCCGTGTATTTCT

GCAAGCGGTGGGACTACTTCGACTACTGGGGCCAGGGAACCACCCTGACCGTGT

CCAGCAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCGGTACCAATCCAATCGAG

CTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTAT

CATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCA

TTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACC

GACTTGGAAAGGTC SEQ ID NO: 857 [00899] Construct pJAQ741 [VSV-G Signal Peptide]- [CD 117 scFv 2D2 Targeting

Domain] -[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCCA

AGTGCAGCTGCAGCAGAGCGACGCCGAGCTGGTGAAGCCCGGAGCCTCCGTGAA

GATCTCCTGCAAGGCTAGCGGCTACACCTTCACCGACCATGCCATCCACTGGGTG

AAACAGCGGCCTGAGCAGGGCCTGGAATGGATCGGATGTATCAGCCCCGGCAAC

GGCGACATCAAATACAATGAGAAGTTCAAGGGCAAGGCTACACTGTCTGCCGAC

AAGAGCAGCAGCACCGCCTACATGCAGCTGAACAGCCTCACCAGCGAGGACAGC

GCCGTTTACTTCTGCAAGCGGTGGGACTACTTTGATTATTGGGGACAAGGCACCA

CCCTGACAGTGAGCTCTGGCGGAGGTGGCTCTGGAGGCGGTGGATCTGGTGGTG

GCGGATCAGATATTGTGATGACCCAGAGCCACAAGTTCATGAGCACAAGCGTCG

GAGATAGAGTGTCTATCACATGCAAAGCTTCTCAGGACGTGTCCACCACCGTGGC

CTGGTATCAGCAGAAACCTGGCCAGTCTCCTAAGCTGCTGATCTACAGCGCCAGC

TACAGATACACAGGCGTGCCAGACAGATTCACCGGCTCTGGTAGCGGCACAGAC

TTCACCTTCACCATCTCTAGCGTGCAGGCCGAAGATCTGGCCGTGTACTACTGCC

AGCAACACTACAGCACCCCTCCTACCTTTGGCGGAGGCACAAAGCTGGAAATCA

AGGGTACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCT

CTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCC

GAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTA

TACAGACATAGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 858

[00900] Construct pJAQ742 [VSV-G Signal Peptide]- [CD 117 scFv 2D2 Targeting

Domain]-[SGGSx3.2 Linker]-[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCCA

AGTGCAGCTGCAGCAGAGCGACGCCGAGCTGGTGAAGCCCGGAGCCTCCGTGAA

GATCTCCTGCAAGGCTAGCGGCTACACCTTCACCGACCATGCCATCCACTGGGTG

AAACAGCGGCCTGAGCAGGGCCTGGAATGGATCGGATGTATCAGCCCCGGCAAC

GGCGACATCAAATACAATGAGAAGTTCAAGGGCAAGGCTACACTGTCTGCCGAC

AAGAGCAGCAGCACCGCCTACATGCAGCTGAACAGCCTCACCAGCGAGGACAGC

GCCGTTTACTTCTGCAAGCGGTGGGACTACTTTGATTATTGGGGACAAGGCACCA

CCCTGACAGTGAGCTCTGGCGGAGGTGGCTCTGGAGGCGGTGGATCTGGTGGTG

GCGGATCAGATATTGTGATGACCCAGAGCCACAAGTTCATGAGCACAAGCGTCG

GAGATAGAGTGTCTATCACATGCAAAGCTTCTCAGGACGTGTCCACCACCGTGGC

CTGGTATCAGCAGAAACCTGGCCAGTCTCCTAAGCTGCTGATCTACAGCGCCAGC

TACAGATACACAGGCGTGCCAGACAGATTCACCGGCTCTGGTAGCGGCACAGAC

TTCACCTTCACCATCTCTAGCGTGCAGGCCGAAGATCTGGCCGTGTACTACTGCC

AGCAACACTACAGCACCCCTCCTACCTTTGGCGGAGGCACAAAGCTGGAAATCA

AGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCGGTACCAATCCAATCGAGCTT

GTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCAT

AGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTA

AATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGAC

TTGGAAAGGTC SEQ ID NO: 859

[00901] Construct pJAQ749 [VSV-G Signal Peptide]- [CD 117 SRI scFv Targeting

Domain]-[SGGSx3.2 Linker]-[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCCA

AGTGCAGCTGCAGCAGCCTGGAGCCGAGCTGGTGAAACCTGGCGCCAGCGTGAA GATGAGCTGCAAGGCCTCCGGTTATACATTCACCTCCTACAACATGCACTGGGTC

AAACAGACCCCTGGCCAGGGCCTCGAGTGGATCGGCGTGATCTACAGCGGCAAC

GGAGATACCAGCTACAACCAGAAATTCAAGGGCAAGGCCACCCTGACCGCCGAC

AAGTCCAGCAGCACCGCCTACATGCAGATCAACAGCCTGACCAGCGAGGATAGC

GCCGTGTACTATTGCGCCAGAGAGCGGGACACCAGATTTGGAAATTGGGGCCAA

GGCACCCTGGTTACAGTGTCTGCCGCTAAGACCACCGGCGGAGGTGGCTCTGGA

GGCGGTGGATCTGGTGGTGGCGGATCAATCGTGCTGACACAGAGCCCTGCTTCTC

TGGCCGTGTCCCTGGGCCTGCGGGCCACAATTAGCTGTAGAGCCTCTGAGAGCGT

GGACATCTACGGCAATAGCTTCATGCACTGGTACCAGCAAAAGCCTGGCCAGCC

CCCCAAGCTGCTGATCTACCTGGCTAGCAACCTGGAAAGCGGCGTGCCAGCTAG

GTTCAGCGGAAGCGGCTCTAGAACCGACTTCACACTGACCATCGACCCTGTGGA

AGCCGATGACGCCGCCACATACTACTGCCAGCAGAACAACGAGGACCCCTACAC

CTTTGGCGGCGGAACAAAGCTGGAAATCAAGAGCGGTGGGAGCGGCGGGAGCG

GTGGGAGCGGTACCAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGA

AAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTG

GTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGAC

AGATTTATACAGACATAGAGATGAACCGACTTGGAAAGGTC SEQ ID NO: 860

[00902] Construct pJAQ750 [VSV-G Signal Peptide]- [CD 117 scFv 54 Targeting

Domain]-[SGGSx3.2 Linker]-[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCCA

AGTCCAGCTGGTGCAAAGTGGAGCAGAAGTCAAGAAACCCGGAAGCTCAGTCAA

AGTGTCTTGCAAAGCTAGCGGAGGCACGTTCTCAAGTTATGCCATATCCTGGGTG

CGCCAAGCGCCCGGCCAAGGCTTGGAATGGATGGGTGGTATAATACCGATTTTT

GGGACAGCGAATTATGCACAGAAGTTTCAAGGTAGAGTGACGATTACGGCGGAT

GAAAGTACATCCACGGCGTACATGGAGCTGTCCAGTCTGCGGTCAGAAGACACA GCCGTATATTACTGCGCGCGAGGAGGGCTCGATACGGACGAATTTGATCTGTGG

GGGCGGGGGACCTTGGTCACAGTAAGTAGCGGGGGAGGAGGCTCTGGCGGTGGC

GGTTCAGGTGGAGGAGGATCCGACATTCAGATGACTCAATCCCCTTCCTCCCTGA

GTGCCTCCGTCGGGGACAGAGTAACGATTACCTGTAGGGCCAGCCAAAGTATTA

ACAGCTACCTGAATTGGTATCAGCAGAAGCCCGGCAAAGCCCCGAAGCTCTTGA

TATACGCCGCGTCCTCCTTGCAAAGTGGGGTGCCGTCTAGATTCAGCGGTAGCGG

TAGTGGAACGGATTTTACGCTTACTATATCTAGTCTTCAACCGGAGGATTTTGCT

ACTTATTATTGTCAACAAGGAGTGTCCGATATCACGTTTGGCGGTGGGACAAAGG

TGGAAATTAAAAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCGGTACCAATCCA

ATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTT

CTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATC

TTTGCATTAAATTAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGA

TGAACCGACTTGGAAAGGTC SEQ ID NO: 861

[00903] Construct pJAQ751 [VSV-G Signal Peptide]- [CD 117 scFv 61 Targeting

Domain] -[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

GGTGCAGCTGCTGGAAAGCGGAGGCGGCCTGGTGCAGCCTGGCGGCTCTCTGCG

GCTGTCTTGCGCCGCTAGCGGCTTCACATTTAGCAGCTACGTGATGATCTGGGTT

AGACAGGCCCCTGGAAAAGGACTGGAGTGGGTCTCCTCTATCAGCGGCGATAGC

GTCACCACCTACTATGCCGACAGCGTGAAGGGCAGATTTACAATTAGCAGAGAT

AACAGCAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGCCGAGGACACC

GCCGTGTACTACTGCGCCAAGGGCCCTCCAACCTACCACACAAACTACTACTACA

TGGACGTGTGGGGCAAAGGCACCACAGTGACCGTGTCCAGCGGCGGCGGAGGCT

CTGGAGGCGGCGGCAGCGGCGGAGGAGGCAGCGACATCCAGATGACCCAGAGC

CCTAGCTCCGTGTCCGCCTCTGTGGGCGACAGAGTGACAATCACCTGCAGAGCCA

GCCAGGGTATCAGCTCTTGGCTGGCCTGGTACCAGCAAAAGCCTGGCAAGGCCC CTAAGCTGCTGATCTACGCTGCTTCTAGCCTGCAAAGCGGAGTGCCCAGCCGGTT

CAGCGGCAGCGGCAGCGGCACTGATTTCACCCTGACAATCTCTTCCCTCCAGCCC

GAGGACTTCGCCACCTACTATTGTCAGCAGACCAATAGCTTCCCCTACACCTTCG

GCGGCGGCACAAAGGTGGAAATCAAGGGTACCAATCCAATCGAGCTTGTAGAAG

GTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTA

ATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAA

GCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAA

GGTC SEQ ID NO: 862

[00904] Construct pJAQ752 [VSV-G Signal Peptide]- [CD 117 scFv 67 Targeting

Domain] -[VSVGss TM]

ATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCGGTACCGA

GGTGCAGCTGGTGGAAAGCGGCGGAGGCCTGGTTCAGCCCGGCGGAAGCCTGCG

GCTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCGACGCCGACATGGACTGGGT

GCGGCAGGCCCCTGGAAAAGGCCTGGAATGGGTCGGCCGCACCAGAAACAAGG

CCGGCTCTTATACAACCGAGTACGCTGCTTCTGTGAAGGGCAGATTCACAATTTC

TAGAGATGACAGCAAGAACAGCCTGTACCTGCAAATGAATTCCCTGAAGACCGA

GGACACCGCCGTGTACTACTGCGCCAGAGAGCCTAAGTACTGGATCGACTTCGA

CCTGTGGGGCAGAGGCACACTGGTGACAGTGTCCTCCGGCGGAGGTGGCTCTGG

AGGCGGTGGATCTGGTGGTGGCGGATCAGATATCCAGATGACCCAGAGCCCCAG

CAGCCTCAGCGCCAGCGTGGGAGATAGAGTGACCATCACATGCAGAGCCTCCCA

GTCTATCAGCAGCTACCTGAACTGGTACCAGCAGAAGCCCGGCAAAGCCCCTAA

GCTGCTGATCTACGCCGCTTCTTCTCTGCAGAGCGGCGTGCCTAGCCGGTTCAGC

GGCAGCGGCAGCGGTACAGACTTTACCCTGACCATCAGCTCCCTGCAGCCTGAG

GATTTCGCCACCTACTATTGTCAGCAAAGCTACATCGCCCCATACACCTTTGGCG

GCGGAACCAAGGTGGAAATCAAGGGTACCAATCCAATCGAGCTTGTAGAAGGTT

GGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATC ATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCA

CACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGGT

C SEQ ID NO: 863

[00905] Construct pJAQ782 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]- [SGGSx3.1 Linker]-[CD8a trunc Hinge]-[CD162 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

AGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCA

CCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCT

GTCTGCTGGCTATCCTGATCCTGGCCCTGGTCGCCACAATCTTCTTCGTGTGCACC

GTGGTGCTGGCCGTGAGACTGAGCAGAAAGGGCCACATGTACCCTGTGCGGAAC

SEQ ID NO: 864

[00906] Construct pJAQ783 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]- [SGGSx3.1 Linker]-[CD8a trunc Hinge]-[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

AGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCA

CCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCT

GTCCTCTGTTCATCCCCGTGGCCGTGATGGTGACCGCCTTCAGCGGCCTGGCTTTT

ATCATCTGGCTGGCCAGAAGACTGAAGAAGGGCAAGAAATCTAAGCGG

SEQ ID NO: 865

[00907] Construct pJAQ784 [CD8a Signal Peptide] -[CXCL 12 Targeting Domain]- [SGGSx3.1 Linker]-[CD8a trunc Hinge]-[ICAM1 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTG

CCTCAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTC

GAAAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCA

AACTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGC

ATTGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAG

AGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCA

CCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCT GTATCGTGATCATCACCGTGGTCGCCGCCGCTGTGATCATGGGCACAGCCGGCCT

GAGCACCTACCTGTACAACAGACAGAGAAAGATCAAGAAATACCGGCTG

SEQ ID NO: 866

[00908] Construct pJAQ785 [CD8a Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain]-[SGGSx3.1 Linker]-[CD8a trunc Hinge]-[CD43 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTA

CGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCT

AATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTC

TCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGG

ACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCA

AGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAAC

AACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATC

TGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATT

GCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGG

TTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATAC

AGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTC

GACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAA

AACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATG

CCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTAC

ATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGA

ACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCA

TCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCA CACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACAGCGG

TGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTAC

ACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTGGC

ATGCTGCCTGTGGCTGTGCTGGTGGCCCTGCTCGCCGTGATCGTGCTGGTCGCCC

TGCTGCTGCTGTGGCGGAGAAGACAGAAGAGACGGACC SEQ ID NO: 867

[00909] Construct pJAQ786 [CD8a Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain]-[SGGSx3.1 Linker]-[CD8a trunc Hinge]-[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTA

CGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCT

AATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTC

TCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGG

ACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCA

AGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAAC

AACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATC

TGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATT

GCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGG

TTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATAC

AGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTC

GACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAA

AACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATG

CCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTAC

ATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGA ACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCA

TCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCA

CACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACAGCGG

TGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTAC

ACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTCCT

CTGTTCATCCCCGTGGCCGTGATGGTGACCGCCTTCAGCGGCCTGGCTTTTATCAT

CTGGCTGGCCAGAAGACTGAAGAAGGGCAAGAAATCTAAGCGG SEQ ID

NO: 868

[00910] Construct pJAQ787 [CD8a Signal Peptide] -[AdF35 Genscript Codon

Optimized Targeting Domain]-[SGGSx3.1 Linker]-[CD8a trunc Hinge] -[HLA-DRA TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTACCAAAAGAGTGCGGCTGTCTGATAGCTTCAATCCTGTGTACCCCTA

CGAGGACGAGAGCACCTCCCAGCACCCCTTCTACAACCCCGGCTTCATCAGCCCT

AATGGCTTTACCCAAAGCCCAGATGGCGTGCTGACCCTGAAGTGCCTGACCCCTC

TCACCACCACAGGCGGCTCCCTGCAACTGAAGGTGGGCGGAGGACTGACCGTGG

ACGACACCGACGGCACACTGCAGGAGAACATCAGAGCCACCGCCCCTATCACCA

AGAACAACCACAGCGTGGAACTGAGCATCGGCAACGGCCTGGAAACCCAGAAC

AACAAGCTGTGCGCCAAGCTGGGCAATGGCCTGAAGTTCAACAACGGAGATATC

TGTATCAAGGACTCTATCAACACCCTGTGGACCGGAATCAACCCTCCACCTAATT

GCCAGATCGTGGAAAACACCAATACCAACGACGGCAAGCTGACACTCGTGCTGG

TTAAGAACGGAGGCCTGGTCAACGGCTACGTGTCCCTGGTCGGCGTGTCCGATAC

AGTGAACCAGATGTTCACACAGAAGACCGCTAATATTCAGCTGAGACTGTATTTC

GACTCCAGTGGCAACCTGCTGACAGAGGAATCTGACCTGAAAATCCCCCTGAAA AACAAGAGCAGCACCGCCACATCTGAGACAGTGGCCAGCAGCAAGGCCTTCATG

CCTAGCACCACAGCTTATCCTTTTAACACCACCACACGGGACAGCGAGAACTAC

ATCCACGGCATCTGCTACTACATGACCAGCTACGACAGAAGCCTGTTCCCCCTGA

ACATTAGCATCATGCTGAACAGCAGGATGATCAGCAGCAACGTGGCTTACGCCA

TCCAGTTCGAGTGGAACCTGAACGCCAGCGAGAGCCCTGAGTCTAATATCGCCA

CACTGACCACATCTCCTTTTTTCTTCAGCTACATCACCGAAGATGACAACAGCGG

TGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCTAC

ACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAAC

GTGGTGTGCGCCCTGGGCCTGACCGTGAGCCTGGTCGGCATCATCATTGGAACAA

TCTTCATCATCAAGGGCCTGAGAAAGAGCAACGCCGCTGAGCGGAGAGGCCCTC

TG SEQ ID NO: 869

[00911] Construct pJAQ788 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.1 Linker]-[CD8a trunc Hinge]-[CD162 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCC

CCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGC

CCGAGGCCTGTCTGCTGGCTATCCTGATCCTGGCCCTGGTCGCCACAATCTTCTTC

GTGTGCACCGTGGTGCTGGCCGTGAGACTGAGCAGAAAGGGCCACATGTACCCT

GTGCGGAAC SEQ ID NO: 870

[00912] Construct pJAQ789 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.1 Linker]-[CD8a trunc Hinge]-[CD49d.2 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC

GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCC

CCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGC

CCGAGGCCTGTATCGTGATCATCTCTAGCAGCCTGCTGCTGGGCCTGATCGTGCT

GCTGCTGATCAGCTACGTGATGTGGAAGGCCGGCCTCTTCAAAAAACAGTACAA

GTCC SEQ ID NO: 871

[00913] Construct pJAQ790 [CD8a Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.1 Linker]-[CD8a trunc Hinge]-[CD62L TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCT

CCTGTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAA

CAACGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGAT

CACCCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGC

GAGATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGC

AACATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATC

GTGGACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAG

TCTTTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCT

TCAACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGA

TTGCGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGAC

CAAGCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGC

AGCTCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCC GCTATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCT

GTATTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGAT

TAACGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTC

AGGAGGTGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCC

CCCAGACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGC

CCGAGGCCTGTCCTCTGTTCATCCCCGTGGCCGTGATGGTGACCGCCTTCAGCGG

CCTGGCTTTTATCATCTGGCTGGCCAGAAGACTGAAGAAGGGCAAGAAATCTAA

GCGG SEQ ID NO: 872

[00914] Construct pJAQ791 [CD8a Signal Peptide]-[TPO Genscript Optimized

Targeting Domain] -[SGGSx3.1 Linker]-[CD8a trunc Hinge]-[CD162 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTGAACTTACAGAACTGCTGCTGGTCGTGATGCTGCTGCTGACCGCCAG

GCTGACCCTGTCCAGCCCGGCTCCTCCAGCCTGCGACCTGCGGGTGCTGAGCAAG

CTGCTGAGAGATAGCCACGTGCTGCACTCCAGACTGTCTCAATGTCCTGAGGTGC

ACCCTCTGCCTACCCCTGTGCTGCTCCCTGCCGTGGACTTCAGCCTGGGCGAGTG

GAAGACCCAGATGGAAGAGACAAAGGCCCAGGACATCCTGGGCGCCGTGACCCT

GCTGCTTGAGGGCGTGATGGCCGCTCGGGGCCAGCTGGGACCTACCTGCCTGTCC

AGCCTGCTCGGACAGCTGAGTGGACAGGTGCGCCTGCTGCTGGGCGCCCTGCAG

AGCCTGCTGGGGACCCAACTCCCACCTCAGGGCAGAACAACCGCACATAAGGAC

CCCAACGCCATTTTCCTGAGCTTCCAGCACCTGCTGCGGGGCAAGGTGCGGTTTC

TGATGCTGGTGGGCGGCTCCACCCTGTGCGTGCGGAGAGCCCCTCCTACCACCGC

CGTGCCCAGCCGGACATCTCTGGTTCTCACCCTGAACGAGCTGCCTAATAGAACG

AGCGGCCTGCTGGAAACCAACTTCACCGCCAGCGCCAGAACCACAGGCTCTGGT CTGCTGAAATGGCAGCAGGGCTTCAGAGCTAAAATCCCCGGCCTGCTGAACCAG

ACATCTAGAAGCCTTGATCAGATCCCTGGCTACCTGAACAGAATCCACGAGCTGC

TGAACGGCACCAGAGGCCTCTTCCCCGGACCCTCTAGAAGAACCCTGGGAGCTC

CTGATATCAGCAGCGGCACAAGCGACACCGGCAGCCTGCCACCTAACCTGCAAC

CTGGATATAGCCCCAGCCCCACTCACCCCCCCACAGGCCAGTACACCCTGTTTCC

TCTGCCTCCTACACTGCCAACACCCGTGGTCCAGCTGCACCCCCTGCTGCCTGAC

CCTAGCGCCCCTACCCCAACCCCCACCTCTCCTCTGCTGAATACCAGCTACACAC

ACAGCCAGAACCTGTCTCAGGAGGGCAGCGGTGGGAGCGGCGGGAGCGGCGGT

AGCACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCTACCATCGCCAGCC

AGCCTCTGTCCCTGCGGCCCGAGGCCTGTCTGCTGGCTATCCTGATCCTGGCCCT

GGTCGCCACAATCTTCTTCGTGTGCACCGTGGTGCTGGCCGTGAGACTGAGCAGA

AAGGGCCACATGTACCCTGTGCGGAAC SEQ ID NO: 873

[00915] Construct pJAQ792 [B2M Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker]-[CD49d.2 TM]

ATGAGCAGAAGCGTGGCCCTGGCCGTGCTGGCTCTGCTGTCTCTGTCCGGCCTGG

AGGCCAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCT

GTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAA

CGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCAC

CCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGA

GATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAA

CATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTG

GACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCT

TTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCA ACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTG

CGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAA

GCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGC

TCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCT

ATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTA

TTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAA

CGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGG

AGGTGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCA

GACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGA

GGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGAC

ATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGG

TGATCACCCTGTACTGCAGCGGTGGGAGCATCGTGATCATCTCTAGCAGCCTGCT

GCTGGGCCTGATCGTGCTGCTGCTGATCAGCTACGTGATGTGGAAGGCCGGCCTC

TTCAAAAAACAGTACAAGTCC SEQ ID NO: 874

[00916] Construct pJAQ793 [B2M Signal Peptide]-[SCF full Targeting Domain]- [SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker] -[HLA-DRA TM]

ATGAGCAGAAGCGTGGCCCTGGCCGTGCTGGCTCTGCTGTCTCTGTCCGGCCTGG

AGGCCAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCT

GTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAA

CGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCAC

CCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGA

GATGGTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGTTCAGCAA

CATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTG GACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCT

TTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCA

ACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTG

CGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAA

GCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGC

TCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCT

ATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTA

TTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAA

CGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGG

AGGTGAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCA

GACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGA

GGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGAC

ATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGG

TGATCACCCTGTACTGCAGCGGTGGGAGCAACGTGGTGTGCGCCCTGGGCCTGA

CCGTGAGCCTGGTCGGCATCATCATTGGAACAATCTTCATCATCAAGGGCCTGAG

AAAGAGCAACGCCGCTGAGCGGAGAGGCCCTCTG SEQ ID NO: 875

[00917] Construct pJAQ794 [B2M Signal Peptide]-[SCF mutant (V49L/F63L)

Targeting Domain] -[SGGSx3.2 Einker] -[ VS V-G TM]

ATGAGCAGAAGCGTGGCCCTGGCCGTGCTGGCTCTGCTGTCTCTGTCCGGCCTGG

AGGCCAAAAAAACCCAGACCTGGATCCTGACATGCATCTACCTCCAACTGCTCCT

GTTTAACCCTCTGGTGAAGACCGAGGGCATCTGCAGAAATCGGGTGACCAACAA

CGTGAAGGACGTGACAAAGCTGGTGGCTAATCTGCCCAAGGACTACATGATCAC

CCTGAAGTACGTGCCTGGCATGGACGTGCTGCCCAGCCACTGTTGGATCAGCGA

GATGCTGGTGCAGCTGAGCGATTCTCTGACAGATCTGCTGGACAAGCTGAGCAA CATTTCTGAAGGCCTGAGCAATTACAGCATCATCGACAAGCTGGTCAACATCGTG

GACGACCTGGTTGAGTGCGTGAAAGAGAACAGCTCCAAGGACCTGAAAAAGTCT

TTCAAGAGCCCCGAGCCAAGACTGTTCACCCCTGAGGAATTCTTCAGAATCTTCA

ACCGGAGTATCGACGCCTTTAAGGACTTCGTGGTGGCCTCTGAGACATCTGATTG

CGTGGTCAGCAGCACCCTGTCCCCTGAAAAGGATAGCAGAGTGTCCGTGACCAA

GCCATTCATGCTGCCTCCTGTGGCCGCCAGCTCCCTTAGAAACGACAGCAGCAGC

TCTAATAGAAAGGCCAAGAACCCCCCTGGAGATAGCAGCCTGCACTGGGCCGCT

ATGGCCCTGCCTGCCCTGTTCAGCCTGATCATCGGCTTCGCCTTCGGCGCTCTGTA

TTGGAAGAAAAGACAGCCTAGCCTGACCAGGGCCGTGGAAAACATCCAGATTAA

CGAGGAAGATAACGAGATCAGCATGCTGCAGGAGAAGGAACGGGAATTTCAGG

AGGTGAGCGGTGGGAGCGGCGGGAGCGGTGGGAGCATGAAGTGCCTTTTGTACT

TAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCCACACAAC

CAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGCCCGTCAAGCT

CAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCTTACAAGTCAAAATGCC

CAAGAGTCACAAGGCTATTCAAGCAGACGGTTGGATGTGTCATGCTTCCAAATG

GGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGTATATAACACATTCCATC

CGATCCTTCACTCCATCTGTAGAACAATGCAAGGAAAGCATTGAACAAACGAAA

CAAGGAACTTGGCTGAATCCAGGCTTCCCTCCTCAAAGTTGTGGATATGCAACTG

TGACGGATGCCGAAGCAGTGATTGTCCAGGTGACTCCTCACCATGTGCTGGTTGA

TGAATACACAGGAGAATGGGTTGATTCACAGTTCATCAACGGAAAATGCAGCAA

TTACATATGCCCCACTGTCCATAACTCTACAACCTGGCATTCTGACTATAAGGTC

AAAGGGCTATGTGATTCTAACCTCATTTCCATGGACATCACCTTCTTCTCAGAGG

ACGGAGAGCTATCATCCCTGGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACT

TTGCTTATGAAACTGGAGGCAAGGCCTGCAAAATGCAATACTGCAAGCATTGGG

GAGTCAGACTCCCATCAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGC

TGCAGCCAGATTCCCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAG

ACCTCAGTGGATGTAAGTCTAATTCAGGACGTTGAGAGGATCCTGGATTATTCCC

TCTGCCAAGAAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGG

ATCTCAGCTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAAT

CAATGGTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCT

CCAATCCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAAGGGAA

CTGTGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTT

CTGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGT TGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACAT

TCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATACTG

GGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGTAGTTGGAAAA

GCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATTCTTGGTTC

TCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGAAAAGACAGAT

TTATACAGACATAGAGATGAACCGACTTGGAAAG SEQ ID NO: 876

[00918] Construct pJAQ795 [B2M Signal Peptide] -[CXCL 12 Targeting Domain]-

[SGGSx3.1 Linker]-[CD8a Hinge] -[SGGSxl Linker] -[CD62L TM]

ATGAGCAGAAGCGTGGCCCTGGCCGTGCTGGCTCTGCTGTCTCTGTCCGGCCTGG

AGGCCAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCT

CAGCGACGGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGA

AAGCCATGTTGCCAGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCAAA

CTGTGCCCTTCAGATTGTAGCCCGGCTGAAGAACAACAACAGACAAGTGTGCAT

TGACCCGAAGCTAAAGTGGATTCAGGAGTACCTGGAGAAAGCTTTAAACAAGAG

CGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACC

TACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGT

AGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACA

TCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCAC

CCTGTACTGCAGCGGTGGGAGCCCTCTGTTCATCCCCGTGGCCGTGATGGTGACC

GCCTTCAGCGGCCTGGCTTTTATCATCTGGCTGGCCAGAAGACTGAAGAAGGGC

AAGAAATCTAAGCGG SEQ ID NO: 877 [00919] Construct pJAQ796 [CD90 scFvl Targeting Domain] -[CD 8 a trunc Hinge] - [CD28 TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT

GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT

ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG

GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA

TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA

GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT

ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC

TAAATTGGAGTTGAAGACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCT

ACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTTTCTGGGTCCTGG

TTGTGGTGGGCGGAGTGCTGGCCTGCTACAGCCTGCTGGTGACCGTGGCCTTTAT

CATTTTCTGGGTG SEQ ID NO: 878

[00920] Construct pJAQ797 [CD90 scFvl Targeting Domain] -[CD 8 a trunc Hinge] - [CD43 TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT

GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT

ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG

GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA

TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA

GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT

ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC

TAAATTGGAGTTGAAGACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCT

ACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTGGCATGCTGCCTG

TGGCTGTGCTGGTGGCCCTGCTCGCCGTGATCGTGCTGGTCGCCCTGCTGCTGCT

GTGGCGGAGAAGACAGAAGAGACGGACC SEQ ID NO: 879

[00921] Construct pJAQ798 [CD90 scFvl Targeting Domain]-[CD8a Hinge]- [SGGSxl Linker]-[CD49d.2 TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT

GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG

GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA

TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA

GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT

ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC

TAAATTGGAGTTGAAGACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCT

ACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTG

CCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCT

GGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGC

GGTGGGAGCATCGTGATCATCTCTAGCAGCCTGCTGCTGGGCCTGATCGTGCTGC

TGCTGATCAGCTACGTGATGTGGAAGGCCGGCCTCTTCAAAAAACAGTACAAGT

CC SEQ ID NO: 880

[00922] Construct pJAQ799 [CD90 scFvl Targeting Domain]-[CD8a Hinge]- [SGGSxl Linker] -[CD62L TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT

GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT

ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG

GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA

TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT

ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC

TAAATTGGAGTTGAAGACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCT

ACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTG

CCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCT

GGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGC

GGTGGGAGCCCTCTGTTCATCCCCGTGGCCGTGATGGTGACCGCCTTCAGCGGCC

TGGCTTTTATCATCTGGCTGGCCAGAAGACTGAAGAAGGGCAAGAAATCTAAGC

GG SEQ ID NO: 881

[00923] Construct pJAQ800 [CD90 scFvl Targeting Domain]-[CD8a Hinge]- [SGGSxl Linker] -[CD 162 TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT

GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT

ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG

GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA

TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA

GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC

TAAATTGGAGTTGAAGACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCT

ACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTG

CCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCT

GGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGC

GGTGGGAGCCTGCTGGCTATCCTGATCCTGGCCCTGGTCGCCACAATCTTCTTCG

TGTGCACCGTGGTGCTGGCCGTGAGACTGAGCAGAAAGGGCCACATGTACCCTG

TGCGGAAC SEQ ID NO: 882

[00924] Construct pJAQ801 [CD90 scFvl Targeting Domain]-[CD8a Hinge]- [SGGSxl Linker] -[HLA-A2 TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT

GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT

ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG

GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA

TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA

GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT

ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC

TAAATTGGAGTTGAAGACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCT

ACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTG CCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCT

GGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGC

GGTGGGAGCATCGTGGGCATCATCGCCGGACTGGTGCTGTTCGGCGCCGTCATCA

CCGGCGCTGTGGTGGCCGCCGTGATGTGGCGGAGAAAGTCTAGCGACAGAAAGG GC SEQ ID NO: 883

[00925] Construct pJAQ802 [CD90 scFvl Targeting Domain]-[CD8a Hinge]- [SGGSxl Linker] -[HLA-DRA TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT

GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT

ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG

GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA

TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA

GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT

ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC

TAAATTGGAGTTGAAGACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCT

ACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTG

CCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCT

GGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGC

GGTGGGAGCAACGTGGTGTGCGCCCTGGGCCTGACCGTGAGCCTGGTCGGCATC ATCATTGGAACAATCTTCATCATCAAGGGCCTGAGAAAGAGCAACGCCGCTGAG

CGGAGAGGCCCTCTG SEQ ID NO: 884

[00926] Construct pJAQ803 [CD90 scFvl Targeting Domain]-[CD8a Hinge]- [SGGSxl Linker] -[IC AMI TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT

GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT

ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG

GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA

TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA

GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT

ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC

TAAATTGGAGTTGAAGACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCT

ACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTG

CCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCT

GGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGC

GGTGGGAGCATCGTGATCATCACCGTGGTCGCCGCCGCTGTGATCATGGGCACA

GCCGGCCTGAGCACCTACCTGTACAACAGACAGAGAAAGATCAAGAAATACCGG

CTG SEQ ID NO: 885 [00927] Construct pJAQ804 [CD90 scEvl Targeting Domain]-[CD8a Hinge]-

[SGGSxl Linker] -[LFA-1 TM]

ATGCAGGTGCAGCTGCTTCAGCCAGGGGCAGAACTTGTACGGCCCGGCGCAAGC

GTACGCTTGTCCTGCAAAACGAGTGGATATACGTTTACCTCCTACTGGATCAACT

GGGTTAAACAGAGACCGGGTCAAGGTCTTGAGTGGATCGGTAAGATTTTCCCCA

GTGATTCCCACACTAACTATAATCAAAAATTTAAGGATAAAGCTACGTTGACGGT

CGATAAATCATCTTCCACCGCGTATATGCAACTGATATCTCCGACCAGTGAGGAT

TCTGCCGTTTACTATTGCACAAGAGATTTCGACACGCAGTTCTACGCTATGGAAT

ACTGGGGTCAGGGGACTTCTGTAACGGTAAGCTCTGGCAGCGATAGCAACGCGG

GCCATGCGAGCGCGGGCAACACCAGCCAAATTGTCCTGACACAAAGCCCTACAA

TAATGAGTGCATCACCGGGACAAAAGGTTACAATTAACTGCTCTGCGATTAGTA

GCGTGAATTACATGCACTGGTATCAGCAGAAGCCCGGTTCTTCACCTAAACTTTG

GATATATGCTACTAGTAAGCTGACCCTCGGAGTACCGGCTCGTTTTAGTGGAAGT

GGATCAGGGACCAGTTACAGCTTGACGGTTAATTCAATGGTTACAGAAGATGCT

ACTTCCTATTTTTGCCACCAGTGGTCTTCTTATCCTCCTACATTCGGGGCTGGAAC

TAAATTGGAGTTGAAGACCACAACCCCTGCCCCCAGACCACCTACACCTGCTCCT

ACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTAGACCCGCTGCTG

CCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACATCTGGGCCCCTCT

GGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACCCTGTACTGCAGC

GGTGGGAGCTACCTGTACGTGTTGAGCGGCATCGGCGGACTGCTGCTGCTGCTCC

TGATCTTCATCGTGCTGTACAAGGTGGGCTTTTTCAAAAGAAACCTGAAG

SEQ ID NO: 886 [00928] Construct pJAQ805 [CD133 scFv 1 Targeting Domain]-[CD8 trunc Hinge]-

[ICAM1 TM]

ATGGCCGAGGTGCAGCTGCTGGAAAGCGGCGGAGGCCTGGTGCAGCCTGGCGGC

AGCCTGAGACTGAGCTGCGCCGCTAGCGGCTTCACCTTCAGCTCCTACGCCATGA

GCTGGGTTAGACAGGCCCCTGGCAAGGGCCTCGAGTGGGTCAGCGCCATCAGCA

GAACCGGCGGCGTGACCAGATACGCCGACAGCGTGAAGGGCAGATTCACCATCA

GCCGGGACAACTCAAAGAACACCCTGTACCTGCAGATGAACAGCCTGCGGGCCG

AGGATACAGCCGTGTACTACTGCGCCAAGCGGACCAGGCGGTTCGACTACTGGT

GCCAGGGCACCCTGGTGACAGTGTCCAGCAGCCCCAGCTCCCTGTCTGCTTCTGT

GGGCGACAGAGTGACCATCACCTGCAGAGCCAGCCAGAGCATCAGCAGCTACCT

GAACTGGTACCAGCAGAAACCTGGAAAAGCCCCTAAGCTGCTGATCTACAGCGC

TTCTGATCTGCAATCCGGCGTGCCATCTAGATTTTCTGGCAGCGGATCTGGAACC

GATTTTACACTGACCATTTCCAGCCTGCAGCCCGAGGACTTCGCCACCTACTATT

GTCAGCAAACAGCTAATTCTCCTAGCACATTCGGCCAGGGAACAAAGGTGGAAA

TCACTACAACTCCAGCACCCAGACCCCCTACACCTGCTCCAACTATCGCAAGTCA

GCCCCTGTCACTGCGCCCTGAAGCCTGTATCGTGATCATCACCGTGGTCGCCGCC

GCTGTGATCATGGGCACAGCCGGCCTGAGCACCTACCTGTACAACAGACAGAGA

AAGATCAAGAAATACCGGCTG SEQ ID NO: 887

[00929] Construct pJAQ806 [CD133 scFv 2 Targeting Domain]-[CD8 trunc Hinge]- [ICAM1 TM]

ATGGACATCGTGCTGAGCCAGAGCCCAGCTATCATGAGCGCCAGCCCTGGCGAG

AAGGTGACCATCAGCTGCAGCGCTAGCTCCAGCGTGTCTTACATGTACTGGTACC

AGCAAAAGCCCGGCTCTTCTCCAAAGCCCTGGATCTACCGGACCTCTAATCTGGC

CTCTGGCGTGCCCGCCAGATTTTCTGGCAGCGGCAGCGGAACCAGCTACAGCCTG

ACAATCAGCAGCATGGAAGCCGAGGATGCCGCTACCTACTACTGCCAGCAGTAC

CACAGCTACCCTCCTACCTTCGGCGCCGGCACAAAGCTGGAACTGAAAAGCTCC

GGCGGTGGAGGCAGCGGAGGCGGCGGCGGCGGAAGCTCTAGAAGCAGCCTGGA

AGTGAAACTGGTGGAAAGCGGCCCTGAGCTGAAGAAGCCTGGAGAAACCGTGA

AGATCTCCTGTAAAGCCAGCGGCTATACATTTACCGATTACAGCATGAAGTGGGT

CAACCAGGCCCCTGGCAAGGGCCTGAAGTGGATGGGCTGGATTAACACCGAGAC

CGGCGAGCCTAGCTACGCCGACGACTTCAAGGGCAGATTCGCCTTCAGCCTCGA

GACATCTGCTAGCACCGCCTACCTGCAGATCAACAACCTGAAGAACGAGGACAC

CGCCACATACTTCTGCGCCACCGACTATGGCGATTACTTCGACTACTGGGGCCAG

GGAACAACACTGACCGTGTCCTCCACTACAACTCCAGCACCCAGACCCCCTACAC

CTGCTCCAACTATCGCAAGTCAGCCCCTGTCACTGCGCCCTGAAGCCTGTATCGT

GATCATCACCGTGGTCGCCGCCGCTGTGATCATGGGCACAGCCGGCCTGAGCAC

CTACCTGTACAACAGACAGAGAAAGATCAAGAAATACCGGCTG SEQ ID NO: 888

[00930] Construct pPHl [CD8a Signal Peptide] -[Z34C peptide Targeting Domain]- [SGGSx3.1 Linker]-[CD8a Hinge]-[CD28 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTATGTTCAACATGCAGTGTCAGCGGAGATTCTACGAGGCCCTGCACGA

CCCTAATCTGAACGAGGAACAGAGAAACGCCAAGATCAAGAGCATCAGAGATG

ACTGCAGCGGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCA

GACCACCTACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGA GGCCTGTAGACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGAC

ATCTACATCTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGG

TGATCACCCTGTACTGCAGCTTCTGGGTCCTGGTTGTGGTGGGCGGAGTGCTGGC

CTGCTACAGCCTGCTGGTGACCGTGGCCTTTATCATTTTCTGGGTG SEQ ID

NO: 889

[00931] Construct pPH2 [CD8a Signal Peptide] -[Z34C peptide Targeting Domain]- [SGGSxl Linker]-[IgG4 Fc CH3 Hinge]-[CD28 TM]

ATGGCCCTGCCTGTGACCGCCCTGCTGCTCCCCCTGGCCCTGCTGCTGCACGCCG

CTAGACCTATGTTCAACATGCAGTGTCAGCGGAGATTCTACGAGGCCCTGCACGA

CCCTAATCTGAACGAGGAACAGAGAAACGCCAAGATCAAGAGCATCAGAGATG

ACTGCAGCGGTGGGAGCGGCGGGAGCCCCGGCCAACCTCGGGAACCCCAGGTGT

ACACCCTGCCTCCTAGCCAGGAGGAAATGACCAAGAACCAGGTGTCCCTCACAT

GTCTGGTGAAGGGATTCTACCCCAGCGACATCGCCGTGGAATGGGAGAGCAACG

GCCAGCCTGAGAACAACTACAAGACCACCCCTCCAGTGCTGGACAGCGATGGCA

GCTTCTTTCTGTATAGCAGACTGACCGTGGACAAGTCCAGATGGCAGGAGGGCA

ATGTGTTCAGCTGCAGCGTGATGCACGAGGCTCTGCACAACCACTACACACAGA

AATCTCTGAGCCTGTCTCTGGGCAAGTCTTTTTGGGTCCTGGTCGTGGTGGGCGG

AGTTCTGGCCTGCTACAGCCTGCTGGTGACAGTGGCCTTCATCATCTTCTGGGTG

SEQ ID NO: 890

[00932] Construct pPH3 [Z34C peptide Targeting Domain]-[SGGSx3.1 Linker]-[CD8a

Hinge]-[CD28 TM]

ATGTTCAACATGCAGTGTCAGCGGAGATTCTACGAGGCCCTGCACGACCCTAATC

TGAACGAGGAACAGAGAAACGCCAAGATCAAGAGCATCAGAGATGACTGCAGC

GGTGGGAGCGGCGGGAGCGGCGGTAGCACCACAACCCCTGCCCCCAGACCACCT

ACACCTGCTCCTACCATCGCCAGCCAGCCTCTGTCCCTGCGGCCCGAGGCCTGTA

GACCCGCTGCTGCCGTGCACACAAGAGGCCTGGATTTCGCCTGCGACATCTACAT

CTGGGCCCCTCTGGCCGGCACCTGCGGCGTGCTGCTGCTCTCTCTGGTGATCACC

CTGTACTGCAGCTTCTGGGTCCTGGTTGTGGTGGGCGGAGTGCTGGCCTGCTACA

GCCTGCTGGTGACCGTGGCCTTTATCATTTTCTGGGTG SEQ ID NO: 891

[00933] Construct pPH4 [Z34C peptide Targeting Domain]-[SGGSx3.1 Linker]-[IgG4

Fc CH3 Hinge]-[CD28 TM]

ATGTTCAACATGCAGTGTCAGCGGAGATTCTACGAGGCCCTGCACGACCCTAATC

TGAACGAGGAACAGAGAAACGCCAAGATCAAGAGCATCAGAGATGACTGCAGC

GGTGGGAGCGGCGGGAGCGGCGGTAGCCCCGGCCAACCTCGGGAACCCCAGGT

GTACACCCTGCCTCCTAGCCAGGAGGAAATGACCAAGAACCAGGTGTCCCTCAC

ATGTCTGGTGAAGGGATTCTACCCCAGCGACATCGCCGTGGAATGGGAGAGCAA

CGGCCAGCCTGAGAACAACTACAAGACCACCCCTCCAGTGCTGGACAGCGATGG

CAGCTTCTTTCTGTATAGCAGACTGACCGTGGACAAGTCCAGATGGCAGGAGGG

CAATGTGTTCAGCTGCAGCGTGATGCACGAGGCTCTGCACAACCACTACACACA

GAAATCTCTGAGCCTGTCTCTGGGCAAGTCTTTTTGGGTCCTGGTCGTGGTGGGC GGAGTTCTGGCCTGCTACAGCCTGCTGGTGACAGTGGCCTTCATCATCTTCTGGG

TG SEQ ID NO: 892

Linkers

[00934] The fusion proteins (e.g., first and second fusion proteins) described herein may include one or more linkers. As defined above, the term “linker,” as used herein, refers to a chemical group or a molecule linking two molecules or moieties, e.g., a binding domain and a cleavage domain of a nuclease. In some embodiments, a linker joins one or more domains of a fusion protein disclosed herein (e.g., a linker joins a targeting domain to a stalk domain or a stalk domain to a transmembrane domain, etc.).

[00935] Typically, the linker is positioned between, or flanked by, two groups, molecules, or other moieties and connected to each one via a covalent bond, thus connecting the two. In some embodiments, the linker is an amino acid or a plurality of amino acids (e.g., a peptide or protein). In some embodiments, the linker is an organic molecule, group, polymer, or chemical moiety. In some embodiments, the linker is 5-100 amino acids in length, for example, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 30-35, 35-40, 40-45, 45-50, 50-60, 60-70, 70-80, 80-90, 90-100, 100-150, or 150-200 amino acids in length. Longer or shorter linkers are also contemplated.

[00936] The linker may be as simple as a covalent bond, or it may be a polymeric linker many atoms in length. In certain embodiments, the linker is a polypeptide, or amino acidbased. In other embodiments, the linker is not peptide-like. In certain embodiments, the linker is a covalent bond (e.g., a carbon-carbon bond, disulfide bond, carbon-heteroatom bond, etc.). In certain embodiments, the linker is a carbon-nitrogen bond of an amide linkage. In certain embodiments, the linker is a cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic or heteroaliphatic linker. In certain embodiments, the linker is polymeric (e.g., polyethylene, polyethylene glycol, polyamide, polyester, etc.). In certain embodiments, the linker comprises a monomer, dimer, or polymer of aminoalkanoic acid. In certain embodiments, the linker comprises an aminoalkanoic acid (e.g., glycine, ethanoic acid, alanine, beta- alanine, 3-aminopropanoic acid, 4- aminobutanoic acid, 5-pentanoic acid, etc.). In certain embodiments, the linker comprises a monomer, dimer, or polymer of aminohexanoic acid (Ahx). In certain embodiments, the linker is based on a carbocyclic moiety (e.g., cyclopentane, cyclohexane). In other embodiments, the linker comprises a polyethylene glycol moiety (PEG). In other embodiments, the linker comprises amino acids. In certain embodiments, the linker comprises a peptide. In certain embodiments, the linker comprises an aryl or heteroaryl moiety. In certain embodiments, the linker is based on a phenyl ring. The linker may include functionalized moieties to facilitate attachment of a nucleophile (e.g., thiol, amino) from the peptide to the linker. Any electrophile may be used as part of the linker. Exemplary electrophiles include, but are not limited to, activated esters, activated amides, Michael acceptors, alkyl halides, aryl halides, acyl halides, and isothiocyanates.

[00937] In some other embodiments, the linker comprises the amino acid sequence (GGGGS)n (SEQ ID NO: 309), (G)_n (SEQ ID NO: 310), (EAAAK)_n (SEQ ID NO: 311), (GGS)n (SEQ ID NO: 312), (SGGS)_n (SEQ ID NO: 313), (XP)_n (SEQ ID NO: 314), or any combination thereof, wherein n is independently an integer between 1 and 30, and wherein X is any amino acid. In some embodiments, the linker comprises the amino acid sequence (GGS)n (SEQ ID NO: 312), wherein n is 1, 3, or 7. In some embodiments, the linker comprises the amino acid sequence SGSETPGTSESATPES (SEQ ID NO: 315). In some embodiments, the linker comprises the amino acid sequence SGGSSGGSSGSETPGTSESATPESSGGSSGGS (SEQ ID NO: 316). In some embodiments, the linker comprises the amino acid sequence SGGSGGSGGS (SEQ ID NO: 317). In some embodiments, the linker comprises the amino acid sequence SGGS (SEQ ID NO: 318). In some embodiments, the linker comprises the amino acid sequence SGGSGGS (SEQ ID NO: 319). In other embodiments, the linker comprises the amino acid sequence

SGGSSGGSSGSETPGTSESATPESAGSYPYDVPDYAGSAAPAAKKKKLDGSGSGGSS GGS (SEQ ID NO: 320, 60AA). In some embodiments, the linker comprises the amino acid sequence GGS, GGSGGS (SEQ ID NO: 322), GGSGGSGGS (SEQ ID NO: 323), SGGSSGGSSGSETPGTSESATPESSGGSSGGSS (SEQ ID NO: 324), SGSETPGTSESATPES (SEQ ID NO: 325), or SGGSSGGSSGSETPGTSESATPESAGSYPYDVPDYAGSAAPAAKKKKLDGSGSGGSS GG S (SEQ ID NO: 326). In some embodiments, the linker comprises the amino acid sequence GGGGSVP (SEQ ID NO: 327). In some embodiments, the linker comprises the amino acid sequence GGGGSAK (SEQ ID NO: 328). In some embodiments, the linker comprises the amino acid sequence VSGGGGS (SEQ ID NO: 329). In some embodiments, the linker comprises a single amino acid. In some embodiments, the linker comprises the amino acid serine (S). [00938] In certain embodiments, linkers may be used to link any of the fusion protein domains disclosed herein.

[00939] In some embodiments, a linker is a non-cleavable linker. In some embodiments, the non-cleavable linker is flexible. In some embodiments, a linker is a cleavable linker (e.g., a linker that can be split or cut by any means). A cleavable linker may be an amino acid sequence. In some embodiments, the linker between the targeting domain and the stalk domain of the fusion proteins comprises a cleavable linker. A cleavable linker may comprise a self-cleaving peptide (e.g., a 2A peptide such as EGRGSLLTCGDVEENPGP (SEQ ID NO: 330), ATNFSLLKQAGDVEENPGP (SEQ ID NO: 331), QCTNYALLKLAGDVESNPGP (SEQ ID NO: 332), or VKQTLNFDLLKLAGDVESNPGP (SEQ ID NO: 333). In some embodiments, a cleavable linker comprises a protease cleavage site that is cut after being contacted by a protease. For example, the present disclosure contemplates the use of cleavable linkers comprising a protease cleavage site of amino acid sequences

TSTLLMENSS (SEQ ID NO: 334), PRSSLYPALTP (SEQ ID NO: 335), VQALVLTQ (SEQ ID NO: 336), PLQVLTLNIERR (SEQ ID NO: 337), or an amino acid sequence at least 90% identical to any one of SEQ ID NO:s: 1-4. In certain embodiments, a cleavable linker comprises an MMLV protease cleavage site of an FMLV protease cleavage site. In certain embodiments, the fusion proteins and BE-VLPs described herein comprise the cleavable linker TSTLLMENSS (SEQ ID NO: 338) joining one or more NES and a napDNAbp. In some embodiments, the linker is cleaved upon delivery of the BE-VLP/fusion protein to a target cell, releasing a free base editor that is capable of translocating into the nucleus of the target cell.

[00940] The protease cleavage site may be any known in the art, or any sequence yet to be discovered, so long as the corresponding protease may be co-packaged in the eVLPs to allow for post-maturation cleavage within the mature eVLP particles. Such cleavage sites and their corresponding proteases include but are not limited to: (a) granzyme A, which recognizes and cleaves a sequence comprising ASPRAGGK (SEQ ID NO:339), (b) granzyme B, which recognizes and cleaves a sequence comprising YEADSLEE (SEQ ID NO: 340), (c) granzyme K, which recognizes and cleaves a sequence comprising YQYRAL (SEQ ID NO: 341), (d) Cathepsin D, which recognizes and cleaves a sequence comprising LGVLIV (SEQ ID NO: 342). Many other combinations of specific proteases and protease cleavage sites may be used in connection with the present disclosure by co-packing a specific protease during the eVLP manufacture process. Such proteases can include, without limitation, Arg-C proteinase, Asp- N Endopeptidase, Caspase 1, Caspase 2, Caspase 3, Caspase 4, Caspase 5, Caspase 7, Caspase 8, Caspase 9, Caspase 10, Chymotrypsin, Clostripain, Enterokinase, Factor Xa, Glutamyl endopeptidase, Granzyme B, Neutrophil elastase, Pepsin, Prolyl-endopeptidase, Proteinase K, Staphylococcal peptidase I, Thermolysin, Thrombin, and Trypsin. Any protease paired with its cognate recognition sequence may be used in the present disclosure proteasesensitive linkers, including any serine protease, cysteine protease, aspartic protease, threonine protease, glutamic protease, metalloprotease, or asparagine peptide lyase (which constitute major classifications of known proteases). The specific protease cleavage sites for said enzymes are well-known in the art and may be utilized in the linkers herein to provide protease-susceptible linkers. eVLP complexes

[00941] Additional aspects of the present disclosure relate to eVLP complexes. In some embodiments, eVLP complexes comprises (i) a fusion protein comprising a transmembrane domain and a targeting domain and (ii) an antibody domain. In some embodiments, the fusion protein further comprises a stalk domain. In some embodiments the fusion proteins comprise at least one of the following non-limiting structures in either the N-C or C-N orientation:

(1) N-term-[targeting domain] -[optional linker]-[stalk domain] -[optional linker]- [transmembrane domain] -C-term;

(2) C-term- [targeting domain] -[optional linker] -[stalk domain] -[optional linker]- [transmembrane domain] -N-term;

(3) N-term-[targeting domain] -[optional linker] -[transmembrane domain] -C-term; and

(4) C-term- [targeting domain] -[optional linker] -[transmembrane domain] -N-term.

[00942] In some embodiments, the targeting domain binds (e.g., non-covalently) to a second targeting domain, which in turn, binds to a target receptor on a target cell (e.g,. HSBC cell). For example, in certain embodiments, the fusion protein comprises a targeting domain comprising an IgG binding peptide configured to bind to an IgG antibody (e.g., second targeting domain). Thus, in some embodiments, the fusion protein comprises the following non-limiting structure in either the N-C or C-N direction, although, other structures and orientations are also contemplated in other embodiments.

(1) [IgG binding peptide] -[optional linker]-[IgG4 Fc CH3]- [optional linker] -[CD28] The IgG binding peptide may be configured to bind to any known domain of the IgG antibody, according to certain embodiments. For instance, in some embodiments, the IgG peptide binds to the Fc region of the IgG antibody. In other embodiments, the IgG peptide binds to the Fab region of the IgG antibody. In other embodiments still, the IgG peptide binds to the Fv region. In some embodiments, the IgG peptide does not bind to the Fv region, as this is likely to reduce the affinity of the antibody for the target receptor on the target cell. In some embodiments, the IgG peptide binds to any subclass of IgG antibodies, including, for example, IgGl, IgG2, IgG3, and IgG4. Non-limiting exemplary embodiments of possible IgG binding peptides for use in any of the fusion proteins disclosed herein include: [00943] CGYWRSEWGLC (SEQ ID NO: 200) [00944] CTGFWEREWGLC (SEQ ID NO: 201) [00945] CLYWPRLWGLC (SEQ ID NO: 202) [00946] CTGYWPKAWGLC (SEQ ID NO: 203) [00947] CYWAWRWGLLGC (SEQ ID NO: 204) [00948] CGYWADVWOIHC (SEQ ID NO: 205) [00949] GCGYWRSEWGLCG (SEQ ID NO: 206) [00950] GCTGFWEREWGLCG (SEQ ID NO: 207) [00951] GCTGYWPKAWGLCG (SEQ ID NO: 208) [00952] GCGYWRSOWGLCG (SEQ ID NO: 209) [00953] GCTGYWPRAWGLCG (SEQ ID NO: 210)

[00954] YDPxTGTWRS[VL] x is any naturally occurring amino acid (SEQ ID NO: 211) [00955] YDPRTGTWRSSIAYGGG (SEQ ID NO: 212)

[00956] YDPGTGTWRSYLRFGGG (SEQ ID NO: 213) [00957] YDPYTGTWRSSIWVLSG (SEQ ID NO: 214) [00958] YDPGTGTWRSWLSFNVG (SEQ ID NO: 215) [00959] YDPWTGTWRSFIWGGGG. (SEQ ID NO: 216) [00960] YDPRTGTWLLYASRLLG (SEQ ID NO: 217) [00961] YDPVTGTWTSSIASWMG (SEQ ID NO: 218) [00962] YDPRTGTWRRSSLSYSG (SEQ ID NO: 219) [00963] R[Q/R/S]xx[G/S]YDPRTGTWRSSIAYGG (SEQ ID NO: 220) [00964] GVVRQWSGYDPRTGTWRSSIAYGGG (SEQ ID NO: 221) [00965] AGSRRAHGYDPRTGTWRSSIAYGGG (SEQ ID NO: 222) [00966] ASVRSWSSYDPRTGTWRSSIAYGGG (SEQ ID NO: 223) [00967] SWRRRGSSYDPRTGTWRSSIAYGGG (SEQ ID NO: 224) [00968] TGRGRSARYDPRTGTWRSSIAYGGG (SEQ ID NO: 225)

[00969] HWVNGRSGYDPRTGTWRSSIAYGGG (SEQ ID NO: 226)

[00970] ERWITWSGYDPRTGTWRSSIAYGGG (SEQ ID NO: 227)

[00971] GSWRWRGYDPRTGTWRSSIAYGGG (SEQ ID NO: 228)

[00972] GAVYRRSFYDPRTGTWRSSIAYRGG (SEQ ID NO: 229)

[00973] GVVRQWSGXXXXXXXXRSSIAYGG (SEQ ID NO: 230)

[00974] GVVRQWSGGGGSGGGGRSSIAYGGG (SEQ ID NO: 231)

[00975] RSSIAYGGG (SEQ ID NO: 232)

[00976] DAAWHLGELVWATYYDPETGTWxPDWxxM (SEQ ID NO: 233)

[00977] DAAWHLGELVWATYYDPETGTWQPDWLYMTTR (SEQ ID NO: 234)

[00978] DAAWHLGELVWATYYDPETGTWAPDWRLMQGQ (SEQ ID NO: 235)

[00979] DAAWHLGELVWATYYDPETGTWLPDWQTMAQK (SEQ ID NO: 236)

[00980] DAAWHLGELVWATYYDPETGTWEPDWQRMLGQ (SEQ ID NO: 237)

[00981] DAAWHLGELVWATYYDPETGTWQPDWRAMSGR (SEQ ID NO: 238)

[00982] DAAWHLGELVWATYYDPETGTWRPDWKWMSTH (SEQ ID NO: 239)

[00983] DAAWHLGELVWATYYDPETGTWEPDWKLMQRP (SEQ ID NO: 240)

[00984] DAAWHLGELVWATYYDPETGTWQPDWDIMAGH (SEQ ID NO: 241)

[00985] DAAWHLGELVWATYYDPETGTWLPDWDVMVRQ (SEQ ID NO: 242)

[00986] DAAWHLGELVWATYYDPETGTWVPDWERMKQH (SEQ ID NO: 243)

[00987] DAAWHLGELVWATYYDPETGTWEPDWSKMRPQ (SEQ ID NO: 244)

[00988] DAAWHLGELVWATYYDPETGTWRPDWAVMATP (SEQ ID NO: 245)

[00989] DAAWHLGELVWATYYDPETGTWKPDWRMMGVP (SEQ ID NO: 246)

[00990] DAAWHLGELVWATYYDPETGTWLPDWDYMSSK (SEQ ID NO: 247)

[00991] DAAWHLGELVWATYYDPETGTWMPDWDRMLRR (SEQ ID NO: 248)

[00992] DAAWHLGELVWATYYDPETGTWTPDWNAMSQR (SEQ ID NO: 249)

[00993] DAAWHLGELVWATYYDPETGTWQPDWKRMTSR (SEQ ID NO: 250)

[00994] DAAWHLGELVWATYYDPETGTWQPDWGRMNSK (SEQ ID NO: 251)

[00995] DAAWHLGELVWATYYDPETGTWAPDWNRMRDFNRSFREV (SEQ ID NO: 252)

[00996] DAAWHLGELVWATYYDPETGTWVPDWDAMSSR (SEQ ID NO: 253)

[00997] DAAWHLGELVWATYYDPETGTWIPDWTRMQTW (SEQ ID NO: 254)

[00998] DAAWHLGELVWATYYDPETGTWKPDWQRMKLH (SEQ ID NO: 255)

[00999] DAAWHLGELVWATYYDPETGTWLPDWSQMRPQ (SEQ ID NO: 256) [001000] DAAWHLGELVWATYYDPETGTWLPDWDTMTPR (SEQ ID NO: 257)

[001001] DAAWHLGELVWATYYDPETGTWQPDWSVMKSL (SEQ ID NO: 258)

[001002] DAAWHLGELVWATYYDPETGTWVPDWDTMH (SEQ ID NO: 259)

[001003] DAAWHLGELVWATYYDPETGTWIPDWRAMSQF (SEQ ID NO: 260)

[001004] DAAWHLGELVWATYYDPETGTWLPDWNLMGQH (SEQ ID NO: 261)

[001005] DAAWHLGELVWATYYDPETGTWRPDWARMEPM (SEQ ID NO: 262)

[001006] DAAWHLGELVWATYYDPETGTWKPDWQVMSPVSNRSFREV (SEQ ID

NO: 263)

[001007] DAAWHLGELVWATYYDPETGTWQPDWEIMRPF (SEQ ID NO: 264)

[001008] EAWHLGELVWATYYDPETGTWRPDWSRMSGR (SEQ ID NO: 265)

[001009] [R/S/G] [A/G/V]xYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQR MLGQ (SEQ ID NO: 266)

[001010] GPGISAFSPGRGVYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDW

QRMLGQ (SEQ ID NO: 267)

[001011] VISLGSDRGVYDPETGTWYDAAWHLGELVWATYYDPET

GTWEPDWQRMLGQ (SEQ ID NO: 268)

[001012] IMSVDGSSARYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 269)

[001013] VDLRAHGGAVYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 270)

[001014] WSRFSSRSVAYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 271)

[001015] GNPSDSASAWYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 272)

[001016] SNFVRSPSAWYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 273)

[001017] IPYGFPGRGEYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQRM

LGQ (SEQ ID NO: 274)

[001018] GPYNIPDSAVYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 275)

[001019] WPLNAPSSAFYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 276) [001020] VPPRFSSSAQYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 277)

[001021] FLVGLHAGAVYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 278)

[001022] WRVDHSSAVYDPETGTWYDAAWHLGELVWATYYDPETTWEPDWQRM

LGQ (SEQ ID NO: 279)

[001023] WMEFYPGRGVYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQ

RMLGQ (SEQ ID NO: 280)

[001024] DGVGPGSRGVYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 281)

[001025] FVSSLPNSAMYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 282)

[001026] GRAFSGSRRWYDPETGTWYDAAWHLGELVWATYYDPETGTWAPDWRL

MQGQ (SEQ ID NO: 283)

[001027] VMATEWRGVYDPETGTWYDATWHLGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 284)

[001028] MMVRPPRLGVYDPEPGTWYDATWHLGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 285)

[001029] ERHLVSDYLHYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 286)

[001030] FSDLDSFGVSYDPETGTWYDAAWHRGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 287)

[001031] LFDNKLKHASYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 288)

[001032] GSCKFSSSCHYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQR

MLGQ (SEQ ID NO: 289)

[001033] LIPPGGISPWYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDWQRM

LGQ (SEQ ID NO: 290)

[001034] LNDFLTPTAWYDPETGTWYDAAWHLGELVWATYYDPETGTWLPDWQT

MAQK (SEQ ID NO: 291)

[001035] GVVRRWSGYDPRTGTWRSSIAYGGG (SEQ ID NO: 292)

[001036] GVVRQAQSGYDPRTGTWRSSIAYGGG (SEQ ID NO: 293)

[001037] GVVRQWAGYDPRTGTWRSSIAYGGG (SEQ ID NO: 294) [001038] GVVRQWSGYDPRTGTWASSIAYGGG (SEQ ID NO: 295) [001039] GVVRQWSGYDPRTGTWRASIAYGGG (SEQ ID NO: 296) [001040] GVVRQWSGYDPRTGTWRSAIAYGGG (SEQ ID NO: 297) [001041] GVVRQWSGYDPRTGTWRSSAAYGGG (SEQ ID NO: 298) [001042] GPGISAFSPGRGVYDPETGTWYDAAWHLGELVWATYYDPETGTWEADWQRML GQ (SEQ ID NO: 299)

[001043] GPGISAFSPGRGVYDPETGTWYDAAWHLGELVWATYYDPETGTWEPAWQRML GQ (SEQ ID NO: 300)

[001044] GPGISAFSPGRGVYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDA QRMLGQ (SEQ ID NO: 301)

[001045] GPGISAFSPGRGVYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDW QAMLGQ (SEQ ID NO: 302)

[001046] GPGISAFSPGRGVYDPETGTWYDAAWHLGELVWATYYDPETGTWEPDW QRALGQ (SEQ ID NO: 303)

[001047] IgGBP cyclic peptide: DCAWHLGELVWCT (SEQ ID NO: 304)

[001048] Z33 peptide: FNMQQQRRFYEALHDPNLNEEQRNAKIKSIRDD (SEQ ID NO: 305

[001049] NKFRGKYK (SEQ ID NO: 306)

[001050] NARKFYKG (SEQ ID NO: 307)

[001051] In some embodiments, an IgG binding peptide comprises an amino acid sequence that is at least 80%, at least 90%, at least 95%, at least 99%, at least 99.5%, or 100% identical to the amino acid sequence of any SEQ ID NO:s: 200-307.

[001052] Additionally, or alternatively, fusion proteins of the present disclosure may comprise targeting domains comprising peptides that bind antibody classes other than, or in addition to, IgG antibodies. For example, in some embodiments, the targeting domain comprises IgA binding peptides (e.g., IgAl and IgA2). In some embodiments, the targeting domain comprises IgD binding peptides (e.g., IgDl and IgD2). In some embodiments, the targeting domain comprises IgE binding peptides. In some embodiments, the targeting domain comprises IgM binding peptides. The targeting domain may bind to any antibody domain, e.g., Fc domain, Fv domain, or Fab domain of any known antibody (e.g., IgG, IgA, IgE, IgM, IgD and their respective subclasses). [001053] As described above, in some embodiments, the fusion proteins disclosed herein comprise a targeting domain that binds to a second targeting domain (e.g., an antibody domain), which in turn, is capable of binding to a specific receptor on a target cell (e.g., HSPC cells). In some embodiments, the second targeting domain is an antibody domain. Any known, or yet to be discovered antibody domain (or fragment thereof), capable of binding to any known, or yet to be discovered cell surface receptor (or fragment thereof) may be used as the second targeting domain. In some embodiments, the antibody domain is configured to bind to an HSPC cell surface receptor. Exemplary embodiments of possible antibodies for use herein, include but are not limited to, anti-CDl 10 antibodies or fragments thereof, anti-c-kit (e.g., CD 117) antibodies or fragments thereof, anti-CXCR4 antibodies or fragments thereof, anti-CD46 antibodies or fragments thereof, anti-Scal antibodies or fragments thereof, or anti-CDl 50 (e.g., SLAM1) antibodies or fragments thereof.

[001054] In some embodiments, the antibody domain binds to one or more of the following antigens (e.g., cell surface receptors) with the following sequences:

[001055] CD 117 (human)

[001056] MRGARGAWDLLCVLLVLLRGQTATSQPSASPGEPSPPSIHPAQSELIVEAG DTLSLTCIDPDFVRWTFKTYFNEMVENKKNEWIQEKAEATRTGTYTCSNSNGLTSSI YVFVRDPAKLFLVGLPLFGKEDSDALVRCPLTDPQVSNYSLIECDGKSLPTDLTFVPN PKAGITIKNVKRAYHRLCVRCAAQRDGTWLHSDKFTLKVRAAIKAIPVVSVPETSHL LKKGDTFTVVCTIKDVSTSVNSMWLKMNPQPQHIAQVKHNSWHRGDFNYERQETL TISSARVDDSGVFMCYANNTFGSANVTTTLKVVEKGFINISPVKNTTVFVTDGENVD LVVEYEAYPKPEHQQWIYMNRTSANKGKDYVKSDNKSNIRYVNQLRLTRLKGTEG GTYTFLVSNSDASASVTFNVYVNTKPEILTYDRLINGMLQCVAEGFPEPTIDWYFCTG AEQRCTTPVSPVDVQVQNVSVSPFGKLVVQSSIDSSVFRHNGTVECKASNDVGKSSA FFNFAFKGNNKEQIQAHTLFTPLLIGFVVAAGAMGIIVMVLTYKYLQKPMYEVQWK VVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSD AAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITE YCCYGDLLNFLRRKRDSFIFSKQEEQAEAALYKNLLHSTEPSCDSSNEYMDMKPGVS YVVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLDDLLSFSYQVAKGMAFLASK NCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFSC VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMVSPEHAPAEMY DVMKTCWDADPLKRPTFKQVVQLIEKQISDSTKHIYSNLANCNPNPENPVVVDHSV

RVNSVGSSASSTQPLLVHEDA (SEQ ID NO: 381)

[001057] CD 117 (mouse)

[001058] MRGARGAWDLLCVLLVLLRGQTATSQPSASPGEPSPPSIHPAQSELIVEAG DTLSLTCIDPDFVRWTFKTYFNEMVENKKNEWIQEKAEATRTGTYTCSNSNGLTSSI

YVFVRDPAKLFLVGLPLFGKEDSDALVRCPLTDPQVSNYSLIECDGKSLPTDLTFVPN PKAGITIKNVKRAYHRLCVRCAAQRDGTWLHSDKFTLKVRAAIKAIPVVSVPETSHL LKKGDTFTVVCTIKDVSTSVNSMWLKMNPQPQHIAQVKHNSWHRGDFNYERQETL TISSARVDDSGVFMCYANNTFGSANVTTTLKVVEKGFINISPVKNTTVFVTDGENVD

LVVEYEAYPKPEHQQWIYMNRTSANKGKDYVKSDNKSNIRYVNQLRLTRLKGTEG GTYTFLVSNSDASASVTFNVYVNTKPEILTYDRLINGMLQCVAEGFPEPTIDWYFCTG

AEQRCTTPVSPVDVQVQNVSVSPFGKLVVQSSIDSSVFRHNGTVECKASNDVGKSSA FFNFAFKGNNKEQIQAHTLFTPLLIGFVVAAGAMGIIVMVLTYKYLQKPMYEVQWK VVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSD AAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITE

YCCYGDLLNFLRRKRDSFIFSKQEEQAEAALYKNLLHSTEPSCDSSNEYMDMKPGVS YVVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLDDLLSFSYQVAKGMAFLASK NCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFSC VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMVSPEHAPAEMY

DVMKTCWDADPLKRPTFKQVVQLIEKQISDSTKHIYSNLANCNPNPENPVVVDHSV RVNSVGSSASSTQPLLVHEDA (SEQ ID NO: 396)

[001059] CXCR4 (human)

[001060] MSIPLPLLQIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIF LTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYF

GNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWI PALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIII SKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKW ISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVST

ESESSSFHSS (SEQ ID NO: 382)

[001061] CXCR4 (mouse) [001062] MEPISVSIYTSDNYSEEVGSGDYDSNKEPCFRDENVHFNRIFLPTIYFIIFLT GIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAMADWYFGK

FLCKAVHIIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKAVYVGVWIPA LLLTIPDFIFADVSQGDISQGDDRYICDRLYPDSLWMVVFQFQHIMVGLVLPGIVILSC YCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYVGISIDSFILLGVIKQGCDFESI VHKWISITEALAFFHCCLNPILYAFLGAKFKSSAQHALNSMSRGSSLKILSKGKRGGH

SSVSTESESSSFHSS (SEQ ID NO: 398)

[001063] CD46 (Human)

[001064] NO:MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIG

KPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPL

NGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTP PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE CKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDP PVPKCLKGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIGKQMVELNMPLT

RLNQPLQQSREAE (SEQ ID NO: 383)

[001065] CD46 (mouse)

[001066] MTAAPLMPDSTHPCRRRKSYTFFWCSLGVYAEALLFLLSHLSDACELPRP FEAMELKGTPKLFYAVGEKIEYKCKKGYLYLSPYLMIATCEPNHTWVPISDAGCIKV

QCTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGDDEAYW NGYPPHCEKIYCLPPPKIKNGTHTLTDINVFKYHEAVSYSCDPTPGPDKFSLVGTSMIF

CAGHNTWSNSPPECKVVKCPNPVLQNGRLISGAGEIFSYQSTVMFECLQGFYMEGSS MVICSANNSWEPSIPKCLKGPRPTHPTKPPVYNYTGYPSPREGIFSQELDAWIIALIVIT SIVGVFILCLIVLRCFEHRKKTNVSAAR (SEQ ID NO: 401)

[001067] CD110 (MPL) (Human):

[001068] MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTC FWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPL

HLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFL RYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGP KQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDL

PGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEE EEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPN

LHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLEL

RPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVL

GLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVE

PSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIAN

HSYLPLSYWQQP (SEQ ID NO: 399)

[001069] CD110 (MPL) (Mouse):

[001070] MPSWALFMVTSCLLLALPNQAQVTSQDVFLLALGTEPLNCFSQTFEDLTC

FWDEEEAAPSGTYQLLYAYRGEKPRACPLYSQSVPTFGTRYVCQFPAQDEVRLFFPL

HLWVKNVSLNQTLIQRVLFVDSVGLPAPPRVIKARGGSQPGELQIHWEAPAPEISDFL

RHELRYGPTDSSNATAPSVIQLLSTETCCPTLWMPNPVPVLDQPPCVHPTASQPHGPA

PFLTVKGGSCLVSGLQAGKSYWLQLRSQPDGVSLRGSWGPWSFPVTVDLPGDAVTI

GLQCFTLDLKMVTCQWQQQDRTSSQGFFRHSRTRCCPTDRDPTWEKCEEEEPRPGS

QPALVSRCHFKSRNDSVIHILVEVTTAQGAVHSYLGSPFWIHQAVLLPTPSLHWREVS

SGRLELEWQHQSSWAAQETCYQLRYTGEGREDWKVLEPSLGARGGTLELRPRARY

SLQLRARLNGPTYQGPWSAWSPPARVSTGSETAWITLVTALLLVLSLSALLGLLLLK

WQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPSKATVTDSCEEVEPSLLEIL

PKSSESTPLPLCPSQPQMDYRGLQPCLRTMPLSVCPPMAETGSCCTTHIANHSYLPLS

YWQQP (SEQ ID NO: 400)

[001071] Seal (mouse)

[001072] MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVG

DEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIY

VFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPD

PKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYL

LREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISS

ARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVE

YEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFL

VSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRC

SASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFA

FKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEIN

GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTV AVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGD

LLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPT

KADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHR

DLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTF

ESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKT

CWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGST

ASSSQPLLVHDDV (SEQ ID NO: 384)

[001073] CD150 (human)

[001074] MDPKGLLSLTFVLFLSLAFGASYGTGGRMMNCPKILRQLGSKVLLPLTYE

RINKSMNKSIHIVVTMAKSLENSVENKIVSLDPSEAGPPRYLGDRYKFYLENLTLGIR

ESRKEDEGWYLMTLEKNVSVQRFCLQLRLYEQVSTPEIKVLNKTQENGTCTLILGCT

VEKGDHVAYSWSEKAGTHPLNPANSSHLLSLTLGPQHADNIYICTVSNPISNNSQTFS

PWPGCRTDPSETKPWAVYAGLLGGVIMILIMVVILQLRRRGKTNHYQTTVEKKSLTI

YAQVQKPGPLQKKLDSFPAQDPCTTIYVAATEPVPESVQETNSITVYASVTLPES(SE

Q ID NO: 385)

[001075] CD150 (mouse)

[001076] MDPKGSLSWRILLFLSLAFELSYGTGGGVMDCPVILQKLGQDTWLPLTNE

HQINKSVNKSVRILVTMATSPGSKSNKKIVSFDLSKGSYPDHLEDGYHFQSKNLSLKI

LGNRRESEGWYLVSVEENVSVQQFCKQLKLYEQVSPPEIKVLNKTQENENGTCSLLL

ACTVKKGDHVTYSWSDEAGTHLLSRANRSHLLHITLSNQHQDSIYNCTASNPVSSIS

RTFNLSSQACKQESSSESSPWMQYTLVPLGVVIIFILVFTAIIMMKRQGKSNHCQPPVE

EKSLTIYAQVQKSGPQEKKLHDALTDQDPCTTIYVAATEPAPESVQEPNPTTVYASV

TLPES (SEQ ID NO: 397)

[001077] CD90 (human)

[001078] MNLAISIALLLTVLQVSRGQKVTSLTACLVDQSLRLDCRHENTSSSPIQYE

FSLTRETKKHVLFGTVGVPEHTYRSRTNFTSKYNMKVLYLSAFTSKDEGTYTCALHH

SGHSPPISSQNVTVLRDKLVKCEGISLLAQNTSWLLLLLLSLSLLQATDFMSL (SEQ

ID NO: 402) [001079] CD90 (Mouse):

MNPAISVALLLSVLQVSRGQKVTSLTACLVNQNLRLDCRHENNTKDNSIQHEFSLTR EKRKHVLSGTLGIPEHTYRSRVTLSNQPYIKVLTLANFTTKDEGDYFCELQVSGANP MSSNKSISVYRDKLVKCGGISLLVQNTSWMLLLLLSLSLLQALDFISL (SEQ ID NO: 403)

[001080] In some embodiments, the target antigen (e.g., cell surface receptor) comprises an amino acid sequence that is at least 80%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of any SEQ ID NO:s: 380-385 and 396-403.

[001081] Other second targeting domains are also contemplated herein, in other embodiments. For example, in some embodiments, the second targeting domain comprises a bivalent molecule (e.g., protein, nucleic acid, carbohydrate, glycoprotein, etc.) comprising a first domain and a second domain. In some embodiments, the first domain of the bivalent molecule binds to a targeting domain of an eVEP fusion protein and a second domain of the bivalent protein binds to a target receptor on a target cell. eVEPs comprising at least one conjugation domain.

[001082] A second strategy, as contemplated herein, for enhancing the selective tropism of eVEPs is to chemically conjugate a desired targeting domain to the surface of the eVLP (e.g., via the envelope glycoprotein). It will be appreciated that although general methods are known in the art for chemically conjugating any of the targeting domains disclosed herein to the surfaces of the contemplated eVLPs, bio-orthogonal click chemistries are uniquely able to perform such reactions with high selectivity and specificity, both in vitro and in vivo.

Without wishing to be bound by any particular theory, it is believed that this high degree of selectively and specificity is because bio-orthogonal click chemistries use chemical functionalities not found in nature. While many types of bio-orthogonal click chemistries are known in the art, the most common reaction performed in biological systems include the copper (I)-catalyzed azide-alkyne cycloaddition reaction and the strain-promoted azidealkyne cycloaddition reaction. The former reaction is the classic click reaction between an azide and an alkyne to form a 5-membered heteroatom ring (e.g., the 1, 2, 3-triazole ring). This reaction is catalyzed by copper, which is toxic and may limit in vivo application of such reactions. The latter reaction remedies this by using a strained alkyne which is capable of reacting with the azide in the absence of the copper catalyst.

[001083] Therefore, in some embodiments, eVLPs of the present disclosure comprise at least one conjugation domain capable of forming a bond with a desired targeting domain. In a first set of embodiments, the conjugation domain is a subdomain of a transmembrane domain. In a second set of embodiments, the conjugation domain is a subdomain of a viral envelope glycoprotein domain. In third set of embodiments, the conjugation domain is a subdomain of a stalk domain. In other embodiments, multiple conjugation subdomains are possible within the eVLPs (e.g., the conjugation domain is a subdomain of the transmembrane domain and the envelope glycoprotein domain).

[001084] In some embodiments, the conjugation domain comprises one or more reactive groups capable of forming a bond with a desired targeting domain comprising a second reactive group (e.g., -COOH + -NH2 or -N3 +-C=C-, etc.) In some embodiments, the reactive group is a chemical group that is naturally occurring in biological systems (e.g., -SH, -NH2, -COOH groups, etc.). In other embodiments, the chemical group is a chemical group that is not naturally occurring in biological systems (e.g., -N3, -C=C-, etc.). The person of ordinary skill may use any method suitable for conjugating a desired targeting domain to the surface of the eVLP, such as those disclosed by G. Hermanson in “Bioconjugate Techniques” 3^rd edition, 2013, which is herein incorporated by reference in its entirety.

[001085] In one set of embodiments, the conjugation domain comprises a reactive group comprising one or more azido functionalities. In other embodiments, the conjugation domain comprises a reactive group. In some embodiments, the reactive groups is a click chemistry handle (e.g., one or more alkyne or strained alkyne functionalities). In other embodiments, the targeting domain comprises a second reactive group. In some embodiments, the second reactive group comprises a click chemistry handle (e.g., one or more azido functionalities). In some embodiments, the second reactive group comprises one or more alkyne or strained alkyne functionalities. In certain embodiments, the first reactive group is configured to react with the second reactive group via a click reaction.

[001086] In certain embodiments, the click chemistry handle comprises an alkene. In certain embodiments, the click chemistry handle comprises a diene. In certain embodiments, the click chemistry handle comprises a dienophile. In certain embodiments, the click chemistry handle comprises a thiol. In certain embodiments, the click chemistry handle comprises a nitrile oxide. In certain embodiments, the click chemistry handle comprises a tetrazine. In certain embodiments, the click chemistry handle comprises an alkyne. In certain embodiments, the click chemistry handle comprises a terminal alkyne. In certain embodiments, the click chemistry handle comprises a strained alkyne. In certain embodiments, the click chemistry handle comprises an optionally substituted cyclooctyne. In certain embodiments, the click chemistry handle comprises a substituted cyclooctyne. In some embodiments, the click chemistry handle can react to form covalent bonds in the presence of a metal catalyst (e.g., copper (II)). In some embodiments, the click chemistry handle comprises a strained alkyne and can react to form covalent bonds in the presence of a metal catalyst (e.g., copper (II)). In some embodiments, the click chemistry handle comprises an optionally substituted cyclooctyne and can react to form covalent bonds in the presence of a metal catalyst (e.g., copper (II)). In some embodiments, the click chemistry handle comprises a substituted cyclooctyne and can react to form covalent bonds in the presence of a metal catalyst (e.g., copper (II)). In some embodiments, the click chemistry handle can react to form covalent bonds in the absence of a metal catalyst. In some embodiments, the click chemistry handle comprises a strained alkyne and can react to form covalent bonds in the absence of a metal catalyst. In some embodiments, the click chemistry handle comprises an optionally substituted cyclooctyne and can react to form covalent bonds in the absence of a metal catalyst. In some embodiments, the click chemistry handle comprises a substituted cyclooctyne and can react to form covalent bonds in the absence of a metal catalyst. In certain embodiments, the click chemistry handle comprises dibenzoazacyclooctyne (DIB AC or DBCO), biarylazacyclooctynone (BARAC), dibenzocyclooctyne (DIBO), difluorinated cyclooctyne (DIFO), bicyclononyne (BCN), dimethoxyazacyclooctyne (DIMAC), monofluorinated cyclooctyne (MOFO), cyclooctyne (OCT), and/or aryl-less cyclooctyne (ALO). In other embodiments, the click chemistry handle comprises an envelope glycoprotein with one or more dienophilic strained alkene functionalities (e.g., cyclopropane glycoengineering to react with tetrazzini-conjugated antibody)

[001087] In some embodiments, the conjugation domain comprises one or more N- azidoacetylglucosamine (GlcNAz)or an acetylated variant thereof. In certain embodiments, the conjugation domain comprises one or more N-azidoacetylmannosamine (ManNAz) or an acetylated variant thereof. In other embodiments, the conjugation domain comprises is one or more N-azidoacetylgalactosamine (GalNAz) or an acetylated variant thereof. In other embodiments still, the conjugation domain comprises one or more6-azidofucose (6AzFuc) or an acetylated variant thereof. In some embodiments, the conjugation domain comprises one or moreN-azidoacetylneuraminic acid (SiaNAz) or an acetylated variant thereof. In one set of embodiments, the conjugation domain comprises one or more N-(4-pentynoyl mannosamine) (ManNAl) or an acetylated variant thereof. In some embodiments, the conjugation domain comprises one or more N-(4-pentynoyl galactosamine) (GalNAl) or an acetylated variant thereof. In other embodiments, the conjugation domain comprises one or more N-(4-pentynoyl glucosamine) (GlcNAl) or an acetylated variant thereof. In some embodiments, the conjugation domain comprises one or more N-(4-pentynoyl neuraminic acid) (SiaNAl) or an acetylated variant thereof. In other embodiments still, the conjugation domain comprises one or more 6-alkynyl fucose or an acetylated variant thereof.

[001088] In some embodiments, the targeting domain comprises a second reactive group comprising a click reagent. In some embodiments, the click reagent comprises an azide functionality. Exemplary embodiments of azide containing compounds that may be incorporated into a targeting domain, include but are not limited to, 3-azido-l-propanamine, 3-azido-l -propanol, l l-azido-3,6,9-trioaundecan-lamine, 4-azidoaniline hydrochloride, and l-azido-4-chlorobenzne, among others. In some embodiments, click reagent comprises an alkyne or strained alkyne functionality. Exemplary embodiments of strained alkyne containing compounds that may be incorporated into a targeting domain include, but are not limited to, difluorocyclooctyne (DIFO), dibenzocyclooctyne (DIBO), Dibenzo-aza- cyclooctyne (DIABC), dibenzocyclooctyne (DBCO), biarylazacyclooctyneones (BARAC), tetramethylthiacycloheptyne (TMTH), and bicyclo[6.1.0]non-3yne (BCN).

[001089] In some embodiments, the targeting domain is any targeting domain within any fusion protein disclosed herein. In other embodiments, the targeting domain is an aptamer. In some embodiments, the aptamer comprises one or more azides. In other embodiments, the aptamer comprises one or more alkynes or strained alkynes. In some embodiments, the aptamer is conjugated to an eVLP comprising one or more azide functional groups. In other embodiments, the aptamer is conjugated to an eVLP comprising one or more alkyne or strained alkyne functional groups. In some embodiments, the aptamer has a nucleic acid sequence GGCGCUCCGACCUUAGUCUCUGCAAGAUAAACCGUGCUAUUGACCACCCUCAA CACACUUAUUUAAUGUAUUGAACGGACCUACGAACCGUGUAGCACAGCAGA (SEQ ID NO: X). In some embodiments, the aptamer has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: X. In some embodiments, the aptamer directs the eVLP to EGFR+ cells; however, other aptamer sequences directed to other receptors are also contemplated herein, in other embodiments.

[001090] In some embodiments, the targeting domain is a lectin. In some embodiments, the lectin comprises one or more azides. In other embodiments, the lectin comprises one or more alkynes or strained alkynes. In some embodiments, the lectin is conjugated to an eVLP comprising one or more azide functional groups. In other embodiments, the lectin is conjugated to an eVLP comprising one or more alkyne or strained alkyne functional groups. Non-limiting examples of lectins include, but are not limited to, Concanavalin A (e.g., ConA), Lentil lectin (e.g., LCH), Snowdrop lectin (e.g., GNA), Ricin (e.g., RCA), Peanut agglutinin (e.g., PNA), Jacalin (e.g, AIL), Hairy vetch lectin (e.g., VVL), Wheat germ agglutinin (e.g., WGA), Elderberry lectin (e.g., SNA), e.g., Maackia amurensis leukoagglutinin (e.g., MAL), Maackia amurensis hemagglutinin (e.g., MAH), Ulex europaeus agglutin (e.g., UEA), and Aleuria aurantia lectin (e.g., AAL). In some embodiments, lectin- conjugated eVLPs may be used to target aberrant glycans on cancer cells.

[001091] In some embodiments, the targeting domain is a glycan. In some embodiments, the glycan comprises one or more azides. In other embodiments, the glycan comprises one or more alkynes or strained alkynes. In some embodiments, the glycan is conjugated to an eVLP comprising one or more azide functional groups. In other embodiments, the glycan is conjugated to an eVLP comprising one or more alkyne or strained alkyne functional groups. In some embodiments, glycan-conjugated eVLPs enhance transduction efficency into cancer cells, e.g., due to the Warburg effect and increased metabolic need for glycans.

[001092] In some embodiments, the targeting domain is a hyaluronic acid. In some embodiments, the hyaluronic acid comprises one or more azides. In other embodiments, the hyaluronic acid comprises one or more alkynes or strained alkynes. In some embodiments, the hyaluronic acid is conjugated to an eVLP comprising one or more azide functional groups. In other embodiments, the hyaluronic acid is conjugated to an eVLP comprising one or more alkyne or strained alkyne functional groups. In some embodiments, hyaluronic acid- conjugated eVLPs enhance binding to CD44+ cells, which is an art recognized biomarker of cancer.

[001093] In some embodiments, the targeting domain is an antibody. In some embodiments, the antibody comprises one or more azides. In other embodiments, the antibody comprises one or more alkynes or strained alkynes. In some embodiments, the antibody is conjugated to an eVLP comprising one or more azide functional groups. In other embodiments, the antibody is conjugated to an eVLP comprising one or more alkyne or strained alkyne functional groups. Any class or subclass of antibody may serve as the targeting domain. For example, in some embodiments, the targeting domain comprises IgG, IgA, IgM, IgE, and IgD. Further, the antibody may be configured to bind to any known receptor on any desired target cell, according to certain embodiments (e.g., anti-CD117, anti- CD5 antibody, anti-CDUO antibody, anti-ckit antibody, anti-CXCR4 antibody, and anti- CD46 antibody, etc.). In some embodiments, eVLPs comprise more than one type of antibody (e.g,. via by performing first bio-orthogonal click reactions using a first antibody followed by a second bio-orthogonal click reaction using a second antibody). Non-limiting examples of antibodies contemplated herein include antibodies directed against CD34, CD150, Sca-1, Flk2, CD201, and CD120.

[001094] In some embodiments, the targeting domain is protein. In some embodiments, the protein comprises one or more azides. In other embodiments, the protein comprises one or more alkynes or strained alkynes. In some embodiments, the protein is conjugated to an eVLP comprising one or more azide functional groups. In other embodiments, the protein is conjugated to an eVLP comprising one or more alkyne or strained alkyne functional groups. Non-limiting examples of proteins contemplated herein include SCF, TPO, AdF35, and CXCL12.

[001095] In some embodiments, the targeting domain is small molecule. In some embodiments, the small molecule comprises one or more azides. In other embodiments, the small molecule comprises one or more alkynes or strained alkynes. In some embodiments, the small molecule is conjugated to an eVLP comprising one or more azide functional groups. In other embodiments, the small molecule is conjugated to an eVLP comprising one or more alkyne or strained alkyne functional groups. Non-limiting exemplary embodiments of small molecules contemplated herein include fluorophores, bisphosphonates, Risendronate, eltrombopag, avatrombopag, plerixafor, LY2510924, TC14012, and CTCE- 9908.

[001096] In some embodiments, the small molecule is an imagining agent and the eVLP is an imaging agent-conjugated eVLP (e.g., a fluorophore-conjugated eVLP). In some embodiments, the imaging agent is a fluorophore. In some embodiments, the imaging agent is a IR dye. In other embodiments, the imaging agent is a dye, e.g., a fluoroscopic dye. In some embodiments, imaging agent-conjugated eVLPs enable in vivo imaging of the distribution of the eVLPs (e.g., biodistribution between the various organs). [001097] Those skilled in the art will understand that the eVLPs contemplated herein may comprise one or more targeting domains disclosed herein. For example, in some embodiments, eVLPs may be conjugated to an aptamer and a lectin. In other embodiments, the eVLP may be conjugated to a glycan, an aptamer, and an imaging agent. Other combinations are also possible in other embodiments. For example, in some embodiments, the eVLP may comprise one or more targeting domains as part of a one or more fusion proteins. Such eVLP constructs may be further modified with additional targeting domains using one or more bio-orthogonal click reactions.

Additional VLP Components

[001098] In various embodiments, the eVLPs disclosed herein are formed via supra- molecular assembly comprising (a) an envelope comprising (i) a lipid membrane (e.g., singlelayer or bi-layer membrane) and a (ii) viral envelope glycoprotein and (b) a multi -protein core region enclosed by the envelope and comprising (i) a Gag protein, (ii) a Gag-Pro-Pol protein, and (iii) a Gag-cargo fusion protein (e.g., a second fusion protein) comprising a Gag protein fused to a cargo protein (e.g., a napDNAbp, base editor, or prime editor) via a cleavable linker (e.g., a protease-cleavable linker). The gag protein comprises, among other components, a viral nucleocapsid protein. In various embodiments, the cargo protein is a napDNAbp (e.g., Cas9). In other embodiments, the cargo protein is a base editor. In other embodiments, the cargo protein is a prime editor. In various other embodiments, the multiprotein core region of the eVLPs further comprises one or more guide RNA molecules (e.g., comprising a unique barcode sequence as described herein) which are complexed with the napDNAbp, base editor, or prime editor to form a ribonucleoprotein (RNP). In various embodiments, the eVLPs are prepared in a producer cell that is transiently transformed with plasmid DNA that encodes the various protein and nucleic acid (gRNA) components of the eVLPs. Without being bound by theory, the components self-assemble at the cell membrane and bud out in accordance with the naturally occurring mechanism of budding (e.g., retroviral budding or the budding mechanism of other envelope viruses) in order to release from the cell fully-matured eVLPs. Once formed, the Gag-Pro-Pol cleaves the protease-sensitive linker of the Gag-cargo (i.e., [Gag] -[cleav able linker] -[cargo], wherein the cargo may in some embodiments be base editor RNP, prime editor RNP, or a napDNAbp RNP), thereby releasing the RNP or other cargo molecule within the eVLP. Thus, in various embodiments, the present disclosure also provides eVLPs in which the cargo has been cleaved off of the gag protein and released within the eVLP. For example, the present disclosure provides eVLPs comprising a group- specific antigen (gag) protease (pro) polyprotein, a cargo protein, and a second fusion protein comprising a gag nucleocapsid protein and a nuclear export sequence (NES), encapsulated by a lipid membrane and a viral envelope glycoprotein. In some embodiments, the present disclosure provides eVLPs comprising a mixture of cleaved and uncleaved products (z.e., a mixture of cargo proteins that have been cleaved from the gag protein and that have not yet been cleaved from the gag protein). In some embodiments, the cargo is fused to one or more additional domains such as one or more NLS.

[001099] Once the eVLP is administered to a recipient cell and taken up by said recipient cell, the contents of the eVLP are released. Once in the cell, the cargo may translocate to the nucleus of the cell (in particular, where NLSs are included on the cargo), where DNA editing may occur at target sites specified by a guide RNA. In some embodiments, the Gag-cargo fusion further comprises one or more nuclear export signals at one or more locations along the length of the fusion polypeptide protein which may be joined by a cleavable linker such that during eVLP assembly in the producer cell, the Gag-cargo fusions (due to presence of competing NLS signals) do not accumulate in the nucleus of the producer cells but instead are available in the cytoplasm to undergo the eVLP assembly process at the cell membrane. Once inside the matured eVLPs following release from the producer cell, the NES may be cleaved by Gag-Pro-Pol thereby separating the cargo from the NES. Upon delivery to a recipient cell, therefore, the cargo will not comprise an NES element, which may otherwise prohibit the transport of the cargo into the nucleus and hinder gene editing activity.

[001100] In some embodiments, the eVLPs comprise a gag-cargo:gag-pro-pol stoichiometry of 25% gag-cargo : 75% gag-pro-pol. In some embodiments, the ratio of gag- pro-polyprotein to gag-cargo is approximately 10:1, approximately 9:1, approximately 8:1, approximately 7:1, approximately 6:1, approximately 5:1, approximately 4:1, approximately 3:1, approximately 2:1, approximately 1.5:1, approximately 1:1, or approximately 0.5:1. [001101] Accordingly, in some embodiments, the eVLPs of the present disclosure comprise (a) an envelope, and (b) a multi-protein core, wherein the envelope comprises a lipid membrane (e.g., a lipid mono- or bi-layer membrane) and a viral envelope glycoprotein, and wherein the multi-protein core comprises a Gag (e.g., a retroviral Gag), a group-specific antigen (gag) protease (pro) polyprotein (z.e., “Gag-Pro-Pol”), and a second fusion protein comprising a Gag-cargo (e.g., Gag-napDNAbp, Gag-base editor, or Gag-prime editor). In various embodiments, the Gag-cargo may comprise a ribonucleoprotein cargo, e.g., a napDNAbp, base editor, or prime editor complexed with a guide RNA. In still further embodiments, the Gag-cargo may comprise one or more NLS sequences and/or one or more NES sequences to regulate the cellular location of the cargo in a cell. An NLS sequence will facilitate the transport of the cargo into the cell’s nucleus to facilitate editing. An NES will do the opposite, i.e., transport the cargo out from the nucleus, and/or prevent the transport of the cargo into the nucleus. In certain embodiments, the NES may be coupled to the second fusion protein by a cleavable linker (e.g., a protease linker) such that during assembly in a producer cell, the NES signal operates to keep the cargo in the cytoplasm and available for the packaging process. However, once matured eVLPs are budded out or released from a producer cell in a mature form, the cleavable linker joining the NES may be cleaved, thereby removing the association of NES with the cargo. Thus, without an NES, the cargo will translocate to the nucleus with its NLS sequences, thereby facilitating editing. Various napDNAbps may be used in the systems of the present disclosure. In some embodiments, the napDNAbp is a Cas9 protein (e.g., a Cas9 nickase, dead Cas9 (dCas9), or another Cas9 variant). In some embodiments, the Cas9 protein is bound to a guide RNA (gRNA). The second fusion protein may further comprise other protein domains, such as effector domains. In some embodiments, the second fusion protein comprises a deaminase domain (e.g., an adenosine deaminase domain or a cytosine deaminase domain). In certain embodiments, the second fusion protein comprises a base editor, such as ABE8e, or any of the other base editors described herein or known in the art. In certain embodiments, the second fusion protein comprises a polymerase (e.g., a reverse transcriptase). In certain embodiments, the second fusion protein comprises a prime editor as described herein, or any prime editor known in the art.

[001102] In some embodiments, the second fusion protein comprises more than one NES (e.g., two NES, three NES, four NES, five NES, six NES, seven NES, eight NES, nine NES, or ten or more NES). In certain embodiments, the second fusion protein further comprises a nuclear localization sequence (NLS), or more than one NLS (e.g., two NLS, three NLS, four NLS, five NLS, six NLS, seven NLS, eight NLS, nine NLS, or ten or more NLS). In certain embodiments, the second fusion protein may comprise at least one NES and one NLS. In certain embodiments, the second fusion protein comprises at least one more NES than NLS (e.g., three NES and one or two NLS).

[001103] The Gag-cargo fusion proteins described herein (e.g., the second fusion protein) comprise one or more cleavable linkers. In one embodiment, the Gag-cargo fusion proteins comprise a cleavable linker joining the Gag to the cargo, such that once the Gag-cargo fusion has been packaged in mature VLPs (which will also contain the Gag-Pro-Pol), the protease activity can cleave the Gag-cargo cleavable linker, thereby releasing the cargo. In some embodiments, a cleavable linker may also be provided in such a location such that when the cleavable linker is cleaved (e.g., by the Gag-Pro-Pol protein), the NES is separated away from the cargo protein. Such an arrangement of the second fusion protein allows the second fusion protein to be exported from the nucleus of a producing cell during VLP production, and the NES can later be cleaved from the second fusion protein after delivery to a target cell, or prior to delivery to the target cell but after packaging into the VLP, releasing the cargo and allowing it to enter the nucleus of the target cell. In some embodiments, the cleavable linker comprises a protease cleavage site (e.g., a Moloney murine leukemia virus (MMLV) protease cleavage site or a Friend murine leukemia virus (FMLV) protease cleavage site). Various protease cleavage sites can be used in any of the second fusion proteins of the present disclosure. In certain embodiments, the protease cleavage site comprises the amino acid sequence TSTLLMENSS (SEQ ID NO: X), PRSSLYPALTP (SEQ ID NO: X), VQALVLTQ (SEQ ID NO: X), PLQVLTLNIERR (SEQ ID NO: X), or an amino acid sequence at least 90% identical to any one of SEQ ID NO:s: X-X. In some embodiments, the protease cleavage site comprises the amino acid sequence of any one of SEQ ID NO:s: X-X comprising one mutation, two mutations, three mutations, four mutations, five mutations, or more than five mutations relative to one of SEQ ID NO:s: X-X. In some embodiments, the cleavable linker of the second fusion protein is cleaved by the protease of the gag-pro polyprotein. In certain embodiments, the cleavable linker of the second fusion protein is not cleaved by the protease of the gag-pro polyprotein until the eVLP has been assembled and delivered into a target cell. In some embodiments, the gag-pro polyprotein of the VLPs described herein comprises an MMLV gag-pro polyprotein or an FMLV gag-pro polyprotein. In some embodiments, the gag nucleocapsid protein of the second fusion protein in the eVLPs described herein comprises an MMLV gag nucleocapsid protein or an FMLV gag nucleocapsid protein.

[001104] In certain embodiments, the fusion protein comprises the following non-limiting structures:

[001105] [gag nucleocapsid protein variant]-[lx-3x NES]-[cleavable linker] -[cargo], wherein ]-[ comprises an optional linker (e.g., an amino acid linker, or any of the linkers provided herein); or [001106] [1 x-3x NES]-[gag nucleocapsid protein variant] -[cleav able linker]-[cargo], wherein ]-[ comprises an optional linker (e.g., an amino acid linker, or any of the linkers provided herein).

[001107] In embodiments in which the cleavable linker has been cleaved by the protease within the eVLP, the eVLP may comprise a fusion protein comprising the structure [gag nucleocapsid protein]- [lx-3x NES], and a free cargo protein.

[001108] In some embodiments, any of the constructs above comprise 3x NES.

[001109] The eVLPs provided by the present disclosure comprise an outer encapsulation layer (or envelope layer) comprising a viral envelope glycoprotein. Any viral envelope glycoprotein described herein, or known in the art, may be used in the eVLPs of the present disclosure. In some embodiments, the viral envelope glycoprotein is an adenoviral envelope glycoprotein, an adeno-associated viral envelope glycoprotein, a retroviral envelope glycoprotein, or a lentiviral envelope glycoprotein. In certain embodiments, the viral envelope glycoprotein is a retroviral envelope glycoprotein. In some embodiments, the viral envelope glycoprotein is a vesicular stomatitis virus G protein (VSVG), a baboon retroviral envelope glycoprotein (BaEVRless), a FuG-B2 envelope glycoprotein, an HIV-1 envelope glycoprotein, or an ecotropic murine leukemia virus (MLV) envelope glycoprotein. In some embodiments, the viral envelope glycoprotein targets the system to a particular cell type (e.g., immune cells, neural cells, retinal pigment epithelium cells, etc.). For example, using different envelope glycoproteins in the eVLPs described herein may alter their cellular tropism, allowing the eVLPs to be targeted to specific cell types. In some embodiments, the viral envelope glycoprotein is a VSVG protein, and the VSVG protein targets the system to retinal pigment epithelium (RPE) cells. In some embodiments, the viral envelope glycoprotein is an HIV-1 envelope glycoprotein, and the HIV-1 envelope glycoprotein targets the system to CD4+ cells. In some embodiments, the viral envelope glycoprotein is a FuG-B2 envelope glycoprotein, and the FuG-B2 envelope glycoprotein targets the system to neurons. [001110] As discussed elsewhere herein, current v4 eVLPs comprise the envelope glycoprotein VSVG, which initiates receptor- mediated endocytosis through the ubiquitously expressed LDL receptor protein (LDLR). While this permits imparts eVLPs with a broad tropism (e.g, the ability to infect many different cell types), in some embodiments, it hinders production of eVLPs with selective tropism (e.g, targeted delivery to specific cell types). Thus, in some embodiments, the envelope glycoprotein comprises a mutated envelope glycoprotein, wherein the mutated glycoprotein has impaired binding affinity for its natural receptor but retains its fusogenic activity. In some embodiments, the eVLPs disclosed herein comprise one or more mutated envelope glycoproteins. In some embodiments, the one or more mutated envelope glycoproteins comprise VSVG. Exemplary embodiments of various mutant VSVG protein contemplated herein include:

[001111] VSVGmut amino acid sequence (K47Q/R354A, del 1-16):

KFTIVFPHNQKGNWKNVPSNYHYCPSSSDLNWHNDLIGTALQVKMPQSHKAIQADG WMCHASKWVTTCDFRWYGPKYITHSIRSFTPSVEQCKESIEQTKQGTWENPGFPPQS CGYATVTDAEAVIVQVTPHHVLVDEYTGEWVDSQFINGKCSNYICPTVHNSTTWHS DYKVKGLCDSNLISMDITFFSEDGELSSLGKEGTGFRSNYFAYETGGKACKMQYCK HWGVRLPSGVWFEMADKDLFAAARFPECPEGSSISAPSQTSVDVSLIQDVERILDYSL CQETWSKIRAGLPISPVDLSYLAPKNPGTGPAFTIINGTLKYFETRYIRVDIAAPILSRM VGMISGTTTEAELWDDWAPYEDVEIGPNGVLRTSSGYKFPLYMIGHGMLDSDLHLS SKAQVFEHPHIQDAASQLPDDESLFFGDTGLSKNPIELVEGWFSSWKSSIASFFFIIGLII GLFLVLRVGIHLCIKLKHTKKRQIYTDIEMNRLGK (SEQ ID NO: 230)

[001112] VSVGmut amino acid sequence (K47Q/R354A):

MKCLLYLAFLFIGVNCKFTIVFPHNQKGNWKNVPSNYHYCPSSSDLNWHNDLIGTA LQVKMPQSHKAIQADGWMCHASKWVTTCDFRWYGPKYITHSIRSFTPSVEQCKESI EQTKQGTWLNPGFPPQSCGYATVTDAEAVIVQVTPHHVLVDEYTGEWVDSQFINGK CSNYICPTVHNSTTWHSDYKVKGLCDSNLISMDITFFSEDGELSSLGKEGTGFRSNYF

AYETGGKACKMQYCKHWGVRLPSGVWFEMADKDLFAAARFPECPEGSSISAPSQTS VDVSLIQDVERILDYSLCQETWSKIRAGLPISPVDLSYLAPKNPGTGPAFTIINGTLKY FETRYIRVDIAAPILSRMVGMISGTTTEAELWDDWAPYEDVEIGPNGVLRTSSGYKFP LYMIGHGMLDSDLHLSSKAQVFEHPHIQDAASQLPDDESLFFGDTGLSKNPIELVEG WFSSWKSSIASFFFIIGLIIGLFLVLRVGIHLCIKLKHTKKRQIYTDIEMNRLGK (SEQ ID NO: 231)

[001113] VSVG amino acid sequence:

MKCLLYLAFLFIGVNCKFTIVFPHNQKGNWKNVPSNYHYCPSSSDLNWHNDLIGTA LQVKMPKSHKAIQADGWMCHASKWVTTCDFRWYGPKYITHSIRSFTPSVEQCKESI EQTKQGTWLNPGFPPQSCGYATVTDAEAVIVQVTPHHVLVDEYTGEWVDSQFINGK CSNYICPTVHNSTTWHSDYKVKGLCDSNLISMDITFFSEDGELSSLGKEGTGFRSNYF

AYETGGKACKMQYCKHWGVRLPSGVWFEMADKDLFAAARFPECPEGSSISAPSQTS VDVSEIQDVERIEDYSECQETWSKIRAGEPISPVDESYEAPKNPGTGPAFTIINGTEKY FETRYIRVDIAAPILSRMVGMISGTTTERELWDDWAPYEDVEIGPNGVLRTSSGYKFP LYMIGHGMLDSDLHLSSKAQVFEHPHIQDAASQLPDDESLFFGDTGLSKNPIELVEG WFSSWKSSIASFFFIIGLIIGLFLVLRVGIHLCIKLKHTKKRQIYTDIEMNRLGK (SEQ ID NO: 232)

[001114] In some embodiments, the mutant VSVG protein comprises an amino acid sequence that is at least 80%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of any SEQ ID NO:s: 230-232.

[001115] It will be appreciated that general methods are known in the art for producing viral vector particles, which generally contain coding nucleic acids of interest, and may also be used for producing the virus-derived particles according to the present invention, which do not contain coding nucleic acids of interest but instead are designed to deliver a protein cargo. [001116] Conventional viral vector particles encompass retroviral, lentiviral, adenoviral, and adeno-associated viral vector particles that are well known in the art. For a review of various viral vector particles that may be used, the one skilled in the art may notably refer to Kushnir et al. (2012, Vaccine, Vol. 31: 58-83), Zeltons (2013, Mol Biotechnol, Vol. 53: 92- 107), Eudwig et al. (2007, Curr Opin Biotechnol, Vol. 18(no 6): 537-55) and Naskalaska et al. (2015, Vol. 64 (no 1): 3-13). Further, references to various methods using virus-derived particles for delivering proteins to cells are found by the one skilled in the art in the article of Maetzig et al. (2012, Current Gene Therapy, Vol. 12: 389-409), as well as the article of Kaczmarczyk et al. (2011, Proc Natl Acad Sci USA, Vol. 108 (no 41): 16998-17003).

[001117] Generally, a virus-like particle that is used according to the present disclosure, which virus-like particle may also be termed “virus-derived particle,” is formed by one or more virus-derived structural protein(s) and/or one more virus-derived envelope protein.

[001118] A virus-like particle that is used according to the present invention is replication incompetent in a host cell wherein it has entered.

[001119] In preferred embodiments, a virus-like particle is formed by one or more retrovirus-derived structural protein(s) and optionally one or more virus-derived envelope protein(s).

[001120] In preferred embodiments, the virus-derived structural protein is a retroviral Gag protein or a peptide fragment thereof. As it is known in the art, Gag and Gag/pol precursors are expressed from full length genomic RNA as polyproteins, which require proteolytic cleavage, mediated by the retroviral protease (PR), to acquire a functional conformation. Further, Gag, which is structurally conserved among the retroviruses, is composed of at least three protein units: matrix protein (MA), capsid protein (CA) and nucleocapsid protein (NC), whereas Pol consists of the retroviral protease, (PR), the retrotranscriptase (RT), and the integrase (IN).

[001121] In some embodiments, a virus-derived particle comprises a retroviral Gag protein but does not comprise a Pol protein.

[001122] As it is known in the art, the host range of retroviral vector, including lentiviral vectors, may be expanded or altered by a process known as pseudotyping. Pseudotyped lentiviral vectors consist of viral vector particles bearing glycoproteins derived from other enveloped viruses. Such pseudotyped viral vector particles possess the tropism of the virus from which the glycoprotein is derived.

[001123] In some embodiments, a virus-like particle is a pseudotyped virus-like particle comprising one or more viral structural protein(s) or viral envelope protein(s) imparting a tropism to the said virus-like particle for certain eukaryotic cells. A pseudotyped virus-like particle as described herein may comprise, as the viral protein used for pseudotyping, a viral envelope protein selected in a group comprising VSVG protein, Measles virus HA protein, Measles virus F protein, Influenza virus HA protein, Moloney virus MLV-A protein, Moloney virus MLV-E protein, Baboon Endogenous retrovirus (BAEV) envelope protein, Ebola virus glycoprotein, and foamy virus envelope protein, or a combination of two or more of these viral envelope proteins.

[001124] A well-known illustration of pseudotyping viral vector particles consists of the pseudotyping of viral vector particles with the vesicular stomatitis virus glycoprotein (VSVG). For the pseudotyping of viral vector particles, one skilled in the art may notably refer to Yee et al. (1994, Proc Natl Acad Sci, USA, Vol. 91: 9564-9568) Cronin et al. (2005, Curr Gene Ther, Vol. 5(no 4): 387-398), which are incorporated herein by reference.

[001125] For producing virus-like particles, and more precisely VSVG pseudotyped viruslike particles, for delivering protein(s) of interest into target cells, one skilled in the art may refer to Mangeot et al. (2011, Molecular Therapy, Vol. 19 (no 9): 1656-1666).

[001126] In some embodiments, a virus-like particle further comprises a viral envelope protein, wherein either (i) the said viral envelope protein originates from the same virus as the viral structural protein, e.g., originates from the same virus as the viral Gag protein, or (ii) the said viral envelope protein originates from a virus distinct from the virus from which originates the viral structural protein, e.g., originates from a virus distinct from the virus from which originates the viral Gag protein.

[001127] As is readily understood by one skilled in the art, a virus-like particle that is used according to the disclosure may be selected in a group comprising Moloney murine leukemia virus-derived vector particles, Bovine immunodeficiency virus-derived particles, Simian immunodeficiency virus-derived vector particles, Feline immunodeficiency virus-derived vector particles, Human immunodeficiency virus-derived vector particles, Equine infection anemia virus-derived vector particles, Caprine arthritis encephalitis virus-derived vector particle, Baboon endogenous virus-derived vector particles, Rabies virus-derived vector particles, Influenza virus-derived vector particles, Norovirus-derived vector particles, Respiratory syncytial virus-derived vector particles, Hepatitis A virus-derived vector particles, Hepatitis B virus-derived vector particles, Hepatitis E virus-derived vector particles, Newcastle disease virus-derived vector particles, Norwalk virus-derived vector particles, Parvovirus-derived vector particles, Papillomavirus-derived vector particles, Yeast retrotransposon-derived vector particles, Measles virus-derived vector particles, and bacteriophage-derived vector particles.

[001128] In particular, a virus-like particle that is used according to the invention is a retrovirus-derived particle. Such retrovirus may be selected among Moloney murine leukemia virus, Bovine immunodeficiency virus, Simian immunodeficiency virus, Feline immunodeficiency virus, Human immunodeficiency virus, Equine infection anemia virus, and Caprine arthritis encephalitis virus.

[001129] In another embodiment, a virus-like particle that is used according to the disclosure is a lentivirus-derived particle. Lentiviruses belong to the retroviruses family, and have the unique ability of being able to infect non-dividing cells.

[001130] Such lentivirus may be selected among Bovine immunodeficiency virus, Simian immunodeficiency virus, Feline immunodeficiency virus, Human immunodeficiency virus, Equine infection anemia virus, and Caprine arthritis encephalitis virus.

[001131] For preparing Moloney murine leukemia virus-derived vector particles, one skilled in the art may refer to the methods disclosed by Sharma et al. (1997, Proc Natl Acad Sci USA, Vol. 94: 10803+- 10808), Guibingua et al. (2002, Molecular Therapy, Vol. 5(no 5): 538-546), which are incorporated herein by reference. Moloney murine leukemia virus- derived (MLV-derived) vector particles may be selected in a group comprising MLV-A- derived vector particles and MLV-E-derived vector particles. [001132] For preparing Bovine Immunodeficiency virus-derived vector particles, one skilled in the art may refer to the methods disclosed by Rasmussen et al. (1990, Virology, Vol. 178(no 2): 435-451), which is incorporated herein by reference.

[001133] For preparing Simian immunodeficiency virus-derived vector particles, including VSVG pseudotyped SIV virus-derived particles, one skilled in the art may notably refer to the methods disclosed by Mangeot et al. (2000, Journal of Virology, Vol. 71(no 18): 8307- 8315), Negre et al. (2000, Gene Therapy, Vol. 7: 1613-1623) Mangeot et al. (2004, Nucleic Acids Research, Vol. 32 (no 12), el02), which are incorporated herein by reference.

[001134] For preparing Feline Immunodeficiency virus-derived vector particles, one skilled in the art may notably refer to the methods disclosed by Saenz et al. (2012, Cold Spring Harb Protoc, (1): 71-76; 2012, Cold Spring Harb Protoc, (1): 124-125; 2012, Cold Spring Harb Protoc, (1): 118-123), which are incorporated herein by reference.

[001135] For preparing Human immunodeficiency virus-derived vector particles, one skilled in the art may notably refer to the methods disclosed by Jalaguier et al. (2011, PlosOne, Vol. 6(no 11), e28314), Cervera et al. (J Biotechnol, Vol. 166(no 4): 152-165), Tang et al. (2012, Journal of Virology, Vol. 86(no 14): 7662-7676), which are incorporated herein by reference.

[001136] For preparing Equine infection anemia virus-derived vector particles, one skilled in the art may notably refer to the methods disclosed by Olsen (1998, Gene Ther, Vol. 5(no 11): 1481-1487), which are incorporated herein by reference.

[001137] For preparing Caprine arthritis encephalitis virus-derived vector particles, one skilled in the art may notably refer to the methods disclosed by Mselli-Lakhal et al. (2006, J Virol Methods, Vol. 136(no 1-2): 177-184), which are incorporated herein by reference.

[001138] For preparing Baboon endogenous virus-derived vector particles, one skilled in the art may notably refer to the methods disclosed by Girard-Gagnepain et al. (2014, Blood, Vol. 124(no 8): 1221-1231), which is incorporated herein by reference.

[001139] For preparing Rabies virus-derived vector particles, one skilled in the art may notably refer to the methods disclosed by Kang et al. (2015, Viruses, Vol. 7: 1134-1152, doi:10.3390/v7031134), Fontana et al. (2014, Vaccine, Vol. 32(no 24): 2799-27804) or to the PCT application published under no WO 2012/0618, which is incorporated herein by reference.

[001140] For preparing Influenza virus-derived vector particles, one skilled in the art may notably refer to the methods disclosed by Quan et al. (2012, Virology, Vol. 430: 127-135) and to Latham et al. (2001, Journal of Virology, Vol. 75(no 13): 6154-6155), which is incorporated herein by reference.

[001141] For preparing Norovirus-derived vector particles, one skilled in the art may notably refer to the methods disclosed by Tome-Amat et al., (2014, Microbial Cell Factories, Vol. 13: 134-142), which is incorporated herein by reference.

[001142] For preparing Respiratory syncytial virus-derived vector particles, one skilled in the art may notably refer to the methods disclosed by Walpita et al. (2015, PlosOne, DOI: 10.1371 /journal. pone.0130755), which is incorporated herein by reference.

[001143] For preparing Hepatitis B virus-derived vector particles, one skilled in the art may notably refer to the methods disclosed by Hong et al. (2013, Vol. 87(no 12): 6615-6624), which is incorporated herein by reference.

[001144] For preparing Hepatitis E virus-derived vector particles, one skilled in the art may notably refer to the methods disclosed by Li et al. (1997, Journal of Virology, Vol. 71(no 10): 7207-7213), which is incorporated herein by reference.

[001145] For preparing Newcastle disease virus-derived vector particles, one skilled in the art may notably refer to the methods disclosed by Murawski et al. (2010, Journal of Virology, Vol. 84(no 2): 1110-1123), which is incorporated herein by reference.

[001146] For preparing Norwalk virus-derived vector particles, one skilled in the art may notably refer to the methods disclosed by Herb st- Kralovetz et al. (2010, Expert Rev Vaccines, Vol. 9(no 3): 299-307), which is incorporated herein by reference.

[001147] For preparing Parvovirus-derived vector particles, one skilled in the art may notably refer to the methods disclosed by Ogasawara et al. (2006, In Vivo, Vol. 20: 319-324), which is incorporated herein by reference.

[001148] For preparing Papillomavirus-derived vector particles, one skilled in the art may notably refer to the methods disclosed by Wang et al. (2013, Expert Rev Vaccines, Vol. 12(no 2): doi:10.1586/erv.l2.151), which is incorporated herein by reference.

[001149] A virus-like particle that is used herein comprises a Gag protein, and most preferably a Gag protein originating from a virus selected from a group consisting of Rous Sarcoma Virus (RSV), Feline Immunodeficiency Virus (FIV), Simian Immunodeficiency Virus (SIV), Moloney Leukemia Virus (MLV), and Human Immunodeficiency Viruses (HIV-1 and HIV-2), especially Human Immunodeficiency Virus of type 1 (HIV-1).

[001150] In some embodiments, a virus-like particle may also comprise one or more viral envelope protein(s). The presence of one or more viral envelope protein(s) may impart to the said virus-derived particle a more specific tropism for the cells which are targeted, as it is known in the art. The one or more viral envelope protein(s) may be selected from a group consisting of envelope proteins from retroviruses, envelope proteins from non-retroviral viruses, and chimeras of these viral envelope proteins with other peptides or proteins. An example of a non-lentiviral envelope glycoprotein of interest is the lymphocytic choriomeningitis virus (LCMV) strain WE54 envelope glycoprotein. These envelope glycoproteins increase the range of cells that can be transduced with retroviral derived vectors.

Polynucleotides encoding eVLPs

[001151] Aspects of the disclosure also relate to one or more polynucleotides that encode for the eVLPs disclosed herein. Additionally, the one or more polynucleotides disclosed herein may also encode any cargo encapsulated within the eVLPs, for example, a base editor or a primer editor. Thus, in some embodiments, the one or more polynucleotides comprises a first nucleic acid sequence encoding a first fusion protein. The fusion protein may be any fusion protein contemplated herein. In some embodiments, the fusion protein comprises a transmembrane domain, a targeting domain, and optionally, a stalk domain.

[001152] In some embodiments, the one or more polynucleotides comprises a second nucleic acid sequence encoding a viral envelope glycoprotein. Any suitable viral envelope glycoprotein known to one of ordinary skill may be used herein. In some embodiments, the viral envelope glycoprotein is an adenoviral envelope glycoprotein, an adeno-associated viral envelope glycoprotein, a retroviral envelope glycoprotein, or a lentiviral envelope glycoprotein. In some embodiments, the viral envelope glycoprotein is a retroviral envelope glycoprotein. Any suitable retroviral envelope glycoprotein known to the artisan of ordinary skill may be used herein, for example, vesicular stomatitis virus G protein (VSVG), baboon retroviral envelope glycoprotein (BaEVRless), FuG-B2 envelope glycoprotein, HIV-1 viral envelope glycoprotein, or ecotropic murine leukemia virus (MLV) envelope glycoprotein.

[001153] In some embodiments, the one or more polynucleotides comprises a third nucleic acid sequence encoding a mutant viral envelope glycoprotein. Any suitable mutant viral envelope glycoprotein known to one of ordinary skill may be used herein. In some embodiments, the mutated viral envelope glycoprotein is mutated version of an adenoviral envelope glycoprotein, an adeno-associated viral envelope glycoprotein, a retroviral envelope glycoprotein, or a lentiviral envelope glycoprotein. In some embodiments, the mutated viral envelope glycoprotein is a mutated version of a retroviral envelope glycoprotein. Any suitable mutated retroviral envelope glycoprotein known to the artisan of ordinary skill may be used herein, for example, mutated vesicular stomatitis virus G protein (VSVG TM), a mutated version of baboon retroviral envelope glycoprotein (BaEVRless), a mutated version of FuG-B2 envelope glycoprotein, a mutated version of HIV- 1 viral envelope glycoprotein, or a mutated version of ecotropic murine leukemia virus (MLV) envelope glycoprotein. [001154] In some embodiments, the one or more polynucleotides comprises a fourth nucleic acid sequence encoding a group- specific (gag) protease (pro) polyprotein. Any suitable gag- pro polyprotein known to one of ordinary skill in the art may be used herein. In certain embodiments, the gag-pro-polyprotein comprises an MMLV gag-pro polyprotein. In other embodiments, the gag-pro-polyprotein comprises a FMLV gag-pro polyprotein. Other gag- pro-polyproteins are contemplated in other embodiments.

[001155] In some embodiments, the one or more polynucleotides further comprise a fifth nucleic acid sequence that encodes for a desired cargo to be delivered to a target cell, for example, a base editor or prime editor. Thus, in some embodiments, the fourth nucleic acid sequence encodes a second fusion protein (e.g., base editor or prime editor). In certain embodiments, the second fusion protein comprises a group specific antigen (gag) nucleocapsid protein. Any suitable gag nucleocapsid protein known to one of ordinary skill may be used herein. The gag nucleocapsid protein, according to some embodiments, comprises an MMFV gag nucleocapsid protein. According to other embodiments, the gag nucleocapsid protein comprises a FMFV gag nucleocapsid protein. In certain embodiments, the second fusion protein comprises a nucleic acid programmable DNA binding protein (napDNAbp). Any suitable napDNAbp known to one of ordinary skill may be used herein. In certain embodiments, the second fusion protein comprises a cleavable linker. Any suitable cleavable linker known to one of ordinary skill may be used herein. In certain embodiments, the second fusion protein comprises a nuclear export sequence. Any suitable nuclear export sequence known to one of ordinary skill may be used herein. Combinations are also possible in some embodiments, for example, in some cases, the second fusion protein comprises a group specific antigen (gag) nucleocapsid protein, a nucleic acid programable DNA binding protein, a cleavable linker, and a nuclear export sequence.

[001156] In some embodiments, the second fusion protein further comprises one or more editing domains. Exemplary editing domains include, but are not limited to, polymerases, recombinases, integrases, adenine oxides, guanine oxidases, guanine methyltransferases, transglycosylases, adenosine methyltransferases, glycosylases, and thymine alkyltransferases. [001157] In some embodiments, the one or more polynucleotides further comprise a sixth nucleic acid sequence that encodes for a single guide RNA (e.g., sgRNA or simply guide RNA, gRNA). As discussed elsewhere herein, gRNAs are a particular type of guide nucleic acid that associates with a napDNAbp, directing the napDNAbp to a specific sequence in a target DNA molecule that includes complementarity to the protospacer sequence of the guide RNA. Any suitable gRNA known to the artisan of ordinary skill may be used herein.

[001158] The one or more polynucleotides may comprise any suitable number polynucleotides, according to certain embodiments. For example, in one set of embodiments, the one or more polynucleotides comprise at least one polynucleotide, at least two polynucleotides, at least three polynucleotides, at least four polynucleotides, at least five polynucleotides, at least six polynucleotides, at least seven polynucleotides, at least eight polynucleotides, at least nine polynucleotides, or at least ten polynucleotides.

[001159] In some embodiments, the one or more polynucleotides may comprise at least 1 nucleic acid sequence, at least 2 nucleic acid sequences, at least 3 nucleic acid sequences, at least 4 nucleic acid sequences, at least 5 nucleic acid sequences, at least 6 nucleic acid sequences, at least 7 nucleic acid sequences, at least 8 nucleic acid sequences, at least 9 nucleic acid sequences, or at least 10 nucleic acid sequences.

[001160] In some embodiments, the one or more polynucleotides comprises (i) a first nucleic acid sequence encoding a first fusion protein, wherein the first fusion protein comprises: (1) a transmembrane domain, (2) optionally, a stalk domain, and (3) a targeting domain, wherein the targeting domain is not a viral envelope glycoprotein, an antibody, or an antibody fragment.

[001161] In some embodiments, the one or more polynucleotides comprises (i) a first nucleic acid sequence encoding a first fusion protein, wherein the first fusion protein comprises:(l) a transmembrane domain; (2) optionally, a stalk domain, and (3) a targeting domain, wherein the targeting domain is not a viral envelope glycoprotein, an antibody, or an antibody fragment.

[001162] In some embodiments, one or more vectors comprise one or more polynucleotides disclosed herein. In some embodiments, the one or more polynucleotides are on different vectors. For example, in one set of embodiments, a first vector comprises a first polynucleotide, a second vector comprises a second polynucleotide, a third vector comprises a third polynucleotide, a fourth vector comprises a fourth polynucleotide, and a fifth vector comprises a fifth polynucleotide. In other embodiments, the one or more polynucleotides are on the same vector. For example, certain embodiments, a first vector comprises a first polynucleotide, a second polynucleotide, a third polynucleotide, a fourth polynucleotide, and a fifth polynucleotide. Other combinations are also possible in other embodiments.

[001163] In some embodiments, the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 109 ([TPO]- [optional linker] -[VS VGTM]). In some embodiments, the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 112 [SCFK9iE^mon°]-[optional linker] -[ VS VGmut]. In some embodiments, the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 133 [ADF35]- [optional linker] -[VS VGTM]. In some embodiments, the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 92 [SCF]- [optional linker] -[ VS VG]. In some embodiments, the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 123 ([SCF]-[optional linker] -[IgG4]- [CD 62]). In some embodiments, the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 113 ([SCF] -[optional linker] -[CD 8a] -[CD43]). In some embodiments, the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 115 ([SCF]-[optional linker]-[CD8a]-[CD62]). In some embodiments, the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 117 ([SCF] -[optional linker] -[CD 8 a]- [HL A- A2]). In some embodiments, the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 118 ([SCF] -[optional linker]- [CD8a]-[HLA-DRA]). In some embodiments, the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 120 ([SCF]- [optional linker]-[CD8a]-[LFA-l]). In some embodiments, the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 197 [Z peptide] -[optional linker]-[IgG4 Fc CH3]- [optional linker]-[CD28].

[001164] Non-limiting examples of the one or more vectors comprising one or more polynucleotides comprising one or more nucleic acid sequences are provided below.

Vectors comprising polynucleotides encoding core VLP elements

[001165] BCLl lA sgRNA

GACGTCGCTAGCTGTACAAAAAAGCAGGCTTTAAAGGAACCAATTCAGTCGACT

GGATCCGGTACCAAGGTCGGGCAGGAAGAGGGCCTATTTCCCATGATTCCTTCAT

ATTTGCATATACGATACAAGGCTGTTAGAGAGATAATTAGAATTAATTTGACTGT

AAACACAAAGATATTAGTACAAAATACGTGACGTAGAAAGTAATAATTTCTTGG

GTAGTTTGCAGTTTTAAAATTATGTTTTAAAATGGACTATCATATGCTTACCGTAA

CTTGAAAGTATTTCGATTTCTTGGCTTTATATATCTTGTGGAAAGGACGAAACAC

CGTTTATCACAGGCTCCAGGAAGTTTTAGAGCTAGAAATAGCAAGTTAAAATAA

GGCTAGTCCGTTATCAACTTGAAAAAGTGGCACCGAGTCGGTGCTTTTTTTAAGC

TTGGGCCGCTCGAGGTACCTCTCTACATATGACATGTGAGCAAAAGGCCAGCAA AAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGC

CCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCG

ACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTC

CTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGC

GTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTC

GCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTT

ATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTG

GCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACA

GAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTA

TCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATC

CGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATT

ACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTG

ACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAA

AAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTA

AAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCA

CCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGT

GTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGAT

ACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGC

CGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCT

ATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCA

ACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGC

TTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTG

TGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGG

CCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATG

CCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAG

AATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATAC

CGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGG

CGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTC

GTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCA

AAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATG

TTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATT

GTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGG

TTCCGCGCACATTTCCCCGAAAAGTGCCACCT (SEQ ID NO: 1) [001166] In some embodiments, the sgRNA has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequences of SEQ ID NO: 1.

[001167] MMLV-gagpol

ATAAATCAATATTGGCTATTGGCCATTGCATACGTTGTATCCATATCATAATATGT

ACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGACT

AGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGT

TCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCC

CCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACT

TTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTAC

ATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATG

GCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAG

TACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACAT

CAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATT

GACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTC

GTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGG

TCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCATCC ACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGCGGCCCC

AAGCTTGGGCATCGTTCTGTGTTGTCTCTGTCTGACTGTGTTTCTGTATTTGTCTG

AAAATATGGGCCAGACTGTTACCACTCCCTTAAGTTTGACCTTAGGTCACTGGAA

AGATGTCGAGCGGATCGCTCACAACCAGTCGGTAGATGTCAAGAAGAGACGTTG

GGTTACCTTCTGCTCTGCAGAATGGCCAACCTTTAACGTCGGATGGCCGCGAGAC

GGCACCTTTAACCGAGACCTCATCACCCAGGTTAAGATCAAGGTCTTTTCACCTG

GCCCGCATGGACACCCAGACCAGGTCCCCTACATCGTGACCTGGGAAGCCTTGG

CTTTTGACCCCCCTCCCTGGGTCAAGCCCTTTGTACACCCTAAGCCTCCGCCTCCT

CTTCCTCCATCCGCCCCGTCTCTCCCCCTTGAACCTCCTCGTTCGACCCCGCCTCG

ATCCTCCCTTTATCCAGCCCTCACTCCTTCTCTAGGCGCCAAACCTAAACCTCAAG

TTCTTTCTGACAGTGGGGGGCCGCTCATCGACCTACTTACAGAAGACCCCCCGCC

TTATAGGGACCCAAGACCACCCCCTTCCGACAGGGACGGAAATGGTGGAGAAGC

GACCCCTGCGGGAGAGGCACCGGACCCCTCCCCAATGGCATCTCGCCTACGTGG

GAGACGGGAGCCCCCTGTGGCCGACTCCACTACCTCGCAGGCATTCCCCCTCCGC

GCAGGAGGAAACGGACAGCTTCAATACTGGCCGTTCTCCTCTTCTGACCTTTACA

ACTGGAAAAATAATAACCCTTCTTTTTCTGAAGATCCAGGTAAACTGACAGCTCT

GATCGAGTCTGTCCTCATCACCCATCAGCCCACCTGGGACGACTGTCAGCAGCTG

TTGGGGACTCTGCTGACCGGAGAAGAAAAACAACGGGTGCTCTTAGAGGCTAGA

AAGGCGGTGCGGGGCGATGATGGGCGCCCCACTCAACTGCCCAATGAAGTCGAT

GCCGCTTTTCCCCTCGAGCGCCCAGACTGGGATTACACCACCCAGGCAGGTAGG

AACCACCTAGTCCACTATCGCCAGTTGCTCCTAGCGGGTCTCCAAAACGCGGGCA

GAAGCCCCACCAATTTGGCCAAGGTAAAAGGAATAACACAAGGGCCCAATGAGT

CTCCCTCGGCCTTCCTAGAGAGACTTAAGGAAGCCTATCGCAGGTACACTCCTTA

TGACCCTGAGGACCCAGGGCAAGAAACTAATGTGTCTATGTCTTTCATTTGGCAG

TCTGCCCCAGACATTGGGAGAAAGTTAGAGAGGTTAGAAGATTTAAAAAACAAG

ACGCTTGGAGATTTGGTTAGAGAGGCAGAAAAGATCTTTAATAAACGAGAAACC

CCGGAAGAAAGAGAGGAACGTATCAGGAGAGAAACAGAGGAAAAAGAAGAAC

GCCGTAGGACAGAGGATGAGCAGAAAGAGAAAGAAAGAGATCGTAGGAGACAT

AGAGAGATGAGCAAGCTATTGGCCACTGTCGTTAGTGGACAGAAACAGGATAGA

CAGGGAGGAGAACGAAGGAGGTCCCAACTCGATCGCGACCAGTGTGCCTACTGC

AAAGAAAAGGGGCACTGGGCTAAAGATTGTCCCAAGAAACCACGAGGACCTCG

GGGACCAAGACCCCAGACCTCCCTCCTGACCCTAGATGACTAGGGAGGTCAGGG

TCAGGAGCCCCCCCCTGAACCCAGGATAACCCTCAAAGTCGGGGGGCAACCCGT CACCTTCCTGGTAGATACTGGGGCCCAACACTCCGTGCTGACCCAAAATCCTGGA

CCCCTAAGTGATAAGTCTGCCTGGGTCCAAGGGGCTACTGGAGGAAAGCGGTAT

CGCTGGACCACGGATCGCAAAGTACATCTAGCTACCGGTAAGGTCACCCACTCTT

TCCTCCATGTACCAGACTGTCCCTATCCTCTGTTAGGAAGAGATTTGCTGACTAA

ACTAAAAGCCCAAATCCACTTTGAGGGATCAGGAGCTCAGGTTATGGGACCAAT

GGGGCAGCCCCTGCAAGTGTTGACCCTAAATATAGAAGATGAGTATCGGCTACA

TGAGACCTCAAAAGAGCCAGATGTTTCTCTAGGGTCCACATGGCTGTCTGATTTT

CCTCAGGCCTGGGCGGAAACCGGGGGCATGGGACTGGCAGTTCGCCAAGCTCCT

CTGATCATACCTCTGAAAGCAACCTCTACCCCCGTGTCCATAAAACAATACCCCA

TGTCACAAGAAGCCAGACTGGGGATCAAGCCCCACATACAGAGACTGTTGGACC

AGGGAATACTGGTACCCTGCCAGTCCCCCTGGAACACGCCCCTGCTACCCGTTAA

GAAACCAGGGACTAATGATTATAGGCCTGTCCAGGATCTGAGAGAAGTCAACAA

GCGGGTGGAAGACATCCACCCCACCGTGCCCAACCCTTACAACCTCTTGAGCGG

GCTCCCACCGTCCCACCAGTGGTACACTGTGCTTGATTTAAAGGATGCCTTTTTCT

GCCTGAGACTCCACCCCACCAGTCAGCCTCTCTTCGCCTTTGAGTGGAGAGATCC

AGAGATGGGAATCTCAGGACAATTGACCTGGACCAGACTCCCACAGGGTTTCAA

AAACAGTCCCACCCTGTTTGATGAGGCACTGCACAGAGACCTAGCAGACTTCCG

GATCCAGCACCCAGACTTGATCCTGCTACAGTACGTGGATGACTTACTGCTGGCC

GCCACTTCTGAGCTAGACTGCCAACAAGGTACTCGGGCCCTGTTACAAACCCTAG

GGAACCTCGGGTATCGGGCCTCGGCCAAGAAAGCCCAAATTTGCCAGAAACAGG

TCAAGTATCTGGGGTATCTTCTAAAAGAGGGTCAGAGATGGCTGACTGAGGCCA

GAAAAGAGACTGTGATGGGGCAGCCTACTCCGAAGACCCCTCGACAACTAAGGG

AGTTCCTAGGGACGGCAGGCTTCTGTCGCCTCTGGATCCCTGGGTTTGCAGAAAT

GGCAGCCCCCTTGTACCCTCTCACCAAAACGGGGACTCTGTTTAATTGGGGCCCA

GACCAACAAAAGGCCTATCAAGAAATCAAGCAAGCTCTTCTAACTGCCCCAGCC

CTGGGGTTGCCAGATTTGACTAAGCCCTTTGAACTCTTTGTCGACGAGAAGCAGG

GCTACGCCAAAGGTGTCCTAACGCAAAAACTGGGACCTTGGCGTCGGCCGGTGG

CCTACCTGTCCAAAAAGCTAGACCCAGTAGCAGCTGGGTGGCCCCCTTGCCTACG

GATGGTAGCAGCCATTGCCGTACTGACAAAGGATGCAGGCAAGCTAACCATGGG

ACAGCCACTAGTCATTCTGGCCCCCCATGCAGTAGAGGCACTAGTCAAACAACC

CCCCGACCGCTGGCTTTCCAACGCCCGGATGACTCACTATCAGGCCTTGCTTTTG

GACACGGACCGGGTCCAGTTCGGACCGGTGGTAGCCCTGAACCCGGCTACGCTG

CTCCCACTGCCTGAGGAAGGGCTGCAACACAACTGCCTTGATATCCTGGCCGAA GCCCACGGAACCCGACCCGACCTAACGGACCAGCCGCTCCCAGACGCCGACCAC

ACCTGGTACACGGATGGAAGCAGTCTCTTACAAGAGGGACAGCGTAAGGCGGGA

GCTGCGGTGACCACCGAGACCGAGGTAATCTGGGCTAAAGCCCTGCCAGCCGGG

ACATCCGCTCAGCGGGCTGAACTGATAGCACTCACCCAGGCCCTAAAGATGGCA

GAAGGTAAGAAGCTAAATGTTTATACTGATAGCCGTTATGCTTTTGCTACTGCCC

ATATCCATGGAGAAATATACAGAAGGCGTGGGTTGCTCACATCAGAAGGCAAAG

AGATCAAAAATAAAGACGAGATCTTGGCCCTACTAAAAGCCCTCTTTCTGCCCAA

AAGACTTAGCATAATCCATTGTCCAGGACATCAAAAGGGACACAGCGCCGAGGC

TAGAGGCAACCGGATGGCTGACCAAGCGGCCCGAAAGGCAGCCATCACAGAGA

CTCCAGACACCTCTACCCTCCTCATAGAAAATTCATCACCCTACACCTCAGAACA

TTTTCATTACACAGTGACTGATATAAAGGACCTAACCAAGTTGGGGGCCATTTAT

GATAAAACAAAGAAGTATTGGGTCTACCAAGGAAAACCTGTGATGCCTGACCAG

TTTACTTTTGAATTATTAGACTTTCTTCATCAGCTGACTCACCTCAGCTTCTCAAA

AATGAAGGCTCTCCTAGAGAGAAGCCACAGTCCCTACTACATGCTGAACCGGGA

TCGAACACTCAAAAATATCACTGAGACCTGCAAAGCTTGTGCACAAGTCAACGC

CAGCAAGTCTGCCGTTAAACAGGGAACTAGGGTCCGCGGGCATCGGCCCGGCAC

TCATTGGGAGATCGATTTCACCGAGATAAAGCCCGGATTGTATGGCTATAAATAT

CTTCTAGTTTTTATAGATACCTTTTCTGGCTGGATAGAAGCCTTCCCAACCAAGA

AAGAAACCGCCAAGGTCGTAACCAAGAAGCTACTAGAGGAGATCTTCCCCAGGT

TCGGCATGCCTCAGGTATTGGGAACTGACAATGGGCCTGCCTTCGTCTCCAAGGT

GAGTCAGACAGTGGCCGATCTGTTGGGGATTGATTGGAAATTACATTGTGCATAC

AGACCCCAAAGCTCAGGCCAGGTAGAAAGAATGAATAGAACCATCAAGGAGAC

TTTAACTAAATTAACGCTTGCAACTGGCTCTAGAGACTGGGTGCTCCTACTCCCC

TTAGCCCTGTACCGAGCCCGCAACACGCCGGGCCCCCATGGCCTCACCCCATATG

AGATCTTATATGGGGCACCCCCGCCCCTTGTAAACTTCCCTGACCCTGACATGAC

AAGAGTTACTAACAGCCCCTCTCTCCAAGCTCACTTACAGGCTCTCTACTTAGTC

CAGCACGAAGTCTGGAGACCTCTGGCGGCAGCCTACCAAGAACAACTGGACCGA

CCGGTGGTACCTCACCCTTACCGAGTCGGCGACACAGTGTGGGTCCGCCGACACC

AGACTAAGAACCTAGAACCTCGCTGGAAAGGACCTTACACAGTCCTGCTGACCA

CCCCCACCGCCCTCAAAGTAGACGGCATCGCAGCTTGGATACACGCCGCCCACG

TGAAGGCTGCCGACCCCGGGGGTGGACCATCCTCTAGACTGACATGGCGCGTTC

AACGCTCTCAAAACCCCTTAAAAATAAGGTTGACGCGTCAACCCGCGAGGCCCC

CTAATCCCCTTAATTCTTCTGATGCTCAGAGGGGTCAGTATCGAATTCCTGCAGC CCCGCTGATCAGCCTCGACTGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCC

TCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTTCCTAATA

AAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGT

GGGGTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGC

TGGGGATGCGGTGGGCTCTATGGCTTCTGAGGCGGAAAGAACCAGCTGGGGCTC

GATCCTCTAGAGCGGCCGCCACCGCGGTGGAGCTCCAATTCGCCCTATAGTGAGT

CGTATTACAATTCACTGGCCGTCGTTTTACAACGTCGTGACTGGGAAAACCCTGG

CGTTACCCAACTTAATCGCCTTGCAGCACATCCCCCTTTCGCCAGCTGGCGTAAT

AGCGAAGAGGCCCGCACCGATCGCCCTTCCCAACAGTTGCGCAGCCTGAATGGC

GAATGGGACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACG

CGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTT

CCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGC

TCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGA

TTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCT

TTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAA

CACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCG

GCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTTTAACA

AAATATTAACGCTTACAATTTAGGTGGCACTTTTCGGGGAAATGTGCGCGGAACC

CCTATTTGTTTATTTTTCTAAATACATTCAAATATGTATCCGCTCATGAGACAATA

ACCCTGATAAATGCTTCAATAATATTGAAAAAGGAAGAGTATGAGTATTCAACA

TTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCA

CCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGT

GGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCC

GAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGCGCGGTAT

TATCCCGTATTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCA

GAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCAT

GACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGC

CAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCAC

AACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGAA

GCCATACCAAACGACGAGCGTGACACCACGATGCCTGTAGCAATGGCAACAACG

TTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAA

TAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCC

GGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGT ATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACA CGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATA GGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATATAC TTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTT TTTGATAATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTTCCACTGAGCGTC AGACCCCGTAGAAAAGATCAAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTA ATCTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGG ATCAAGAGCTACCAACTCTTTTTCCGAAGGTAACTGGCTTCAGCAGAGCGCAGAT ACCAAATACTGTTCTTCTAGTGTAGCCGTAGTTAGGCCACCACTTCAAGAACTCT GTAGCACCGCCTACATACCTCGCTCTGCTAATCCTGTTACCAGTGGCTGCTGCCA GTGGCGATAAGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATA AGGCGCAGCGGTCGGGCTGAACGGGGGGTTCGTGCACACAGCCCAGCTTGGAGC GAACGACCTACACCGAACTGAGATACCTACAGCGTGAGCTATGAGAAAGCGCCA CGCTTCCCGAAGGGAGAAAGGCGGACAGGTATCCGGTAAGCGGCAGGGTCGGA ACAGGAGAGCGCACGAGGGAGCTTCCAGGGGGAAACGCCTGGTATCTTTATAGT CCTGTCGGGTTTCGCCACCTCTGACTTGAGCGTCGATTTTTGTGATGCTCGTCAGG GGGGCGGAGCCTATGGAAAAACGCCAGCAACGCGGCCTTTTTACGGTTCCTGGC CTTTTGCTGGCCTTTTGCTCACATGTTCTTTCCTGCGTTATCCCCTGATTCTGTGGA TAACCGTATTACCGCCTTTGAGTGAGCTGATACCGCTCGCCGCAGCCGAACGACC GAGCGCAGCGAGTCAGTGAGCGAGGAAGCGGAAGAGCGCCCAATACGCAAACC GCCTCTCCCCGCGCGTTGGCCGATTCATTAATGCAGCTGGCACGACAGGTTTCCC GACTGGAAAGCGGGCAGTGAGCGCAACGCAATTAATGTGAGTTAGCTCACTCAT TAGGCACCCCAGGCTTTACACTTTATGCTTCCGGCTCGTATGTTGTGTGGAATTGT GAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCT CGAAATTAACCCTCACTAAAGGGAACAAAAGCTGGTACCGGGCCCCCCCTCGAG ATCCGGCCATTAGCCATATTATTCATTGGTTATATAGC (SEQ ID NO: 2)

[001168] In some embodiments, the MLV-gag-pro-pol protein has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequences of SEQ ID NO:s. 2.

[001169] pCMV-MMLVgag-3xNES-ABE8e

ATGGGCCAGACTGTTACCACTCCCTTAAGTTTGACCTTAGGTCACTGGAAAGATG

TCGAGCGGATCGCTCACAACCAGTCGGTAGATGTCAAGAAGAGACGTTGGGTTA

CCTTCTGCTCTGCAGAATGGCCAACCTTTAACGTCGGATGGCCGCGAGACGGCAC

CTTTAACCGAGACCTCATCACCCAGGTTAAGATCAAGGTCTTTTCACCTGGCCCG

CATGGACACCCAGACCAGGTCCCCTACATCGTGACCTGGGAAGCCTTGGCTTTTG

ACCCCCCTCCCTGGGTCAAGCCCTTTGTACACCCTAAGCCTCCGCCTCCTCTTCCT

CCATCCGCCCCGTCTCTCCCCCTTGAACCTCCTCGTTCGACCCCGCCTCGATCCTC

CCTTTATCCAGCCCTCACTCCTTCTCTAGGCGCCAAACCTAAACCTCAAGTTCTTT

CTGACAGTGGGGGGCCGCTCATCGACCTACTTACAGAAGACCCCCCGCCTTATAG

GGACCCAAGACCACCCCCTTCCGACAGGGACGGAAATGGTGGAGAAGCGACCCC TGCGGGAGAGGCACCGGACCCCTCCCCAATGGCATCTCGCCTACGTGGGAGACG

GGAGCCCCCTGTGGCCGACTCCACTACCTCGCAGGCATTCCCCCTCCGCGCAGGA

GGAAACGGACAGCTTCAATACTGGCCGTTCTCCTCTTCTGACCTTTACAACTGGA

AAAATAATAACCCTTCTTTTTCTGAAGATCCAGGTAAACTGACAGCTCTGATCGA

GTCTGTCCTCATCACCCATCAGCCCACCTGGGACGACTGTCAGCAGCTGTTGGGG

ACTCTGCTGACCGGAGAAGAAAAACAACGGGTGCTCTTAGAGGCTAGAAAGGCG

GTGCGGGGCGATGATGGGCGCCCCACTCAACTGCCCAATGAAGTCGATGCCGCT

TTTCCCCTCGAGCGCCCAGACTGGGATTACACCACCCAGGCAGGTAGGAACCAC

CTAGTCCACTATCGCCAGTTGCTCCTAGCGGGTCTCCAAAACGCGGGCAGAAGCC

CCACCAATTTGGCCAAGGTAAAAGGAATAACACAAGGGCCCAATGAGTCTCCCT

CGGCCTTCCTAGAGAGACTTAAGGAAGCCTATCGCAGGTACACTCCTTATGACCC

TGAGGACCCAGGGCAAGAAACTAATGTGTCTATGTCTTTCATTTGGCAGTCTGCC

CCAGACATTGGGAGAAAGTTAGAGAGGTTAGAAGATTTAAAAAACAAGACGCTT

GGAGATTTGGTTAGAGAGGCAGAAAAGATCTTTAATAAACGAGAAACCCCGGAA

GAAAGAGAGGAACGTATCAGGAGAGAAACAGAGGAAAAAGAAGAACGCCGTA

GGACAGAGGATGAGCAGAAAGAGAAAGAAAGAGATCGTAGGAGACATAGAGA

GATGAGCAAGCTATTGGCCACTGTCGTTAGTGGACAGAAACAGGATAGACAGGG

AGGAGAACGAAGGAGGTCCCAACTCGATCGCGACCAGTGTGCCTACTGCAAAGA

AAAGGGGCACTGGGCTAAAGATTGTCCCAAGAAACCACGAGGACCTCGGGGACC

AAGACCCCAGACCTCCCTCCTGACCCTAGATGACTCTGGCGGCTCACTTCAACTG

CCTCCACTTGAAAGACTGACACTGGGATCATTACAATTACCTCCTTTAGAACGAT

TAACACTCGGTTCACTACAGCTTCCGCCTCTTGAGAGATTGACATTAACGTCCAC

GCTGCTAATGGAGAACTCGTCTGGAGATTACAAAGACGATGACGATAAGAAACG

GACAGCCGACGGAAGCGAGTTCGAGTCACCAAAGAAGAAGCGGAAAGTCTCTG

AGGTGGAGTTTTCCCACGAGTACTGGATGAGACATGCCCTGACCCTGGCCAAGA

GGGCACGGGATGAGAGGGAGGTGCCTGTGGGAGCCGTGCTGGTGCTGAACAATA

GAGTGATCGGCGAGGGCTGGAACAGAGCCATCGGCCTGCACGACCCAACAGCCC

ATGCCGAAATTATGGCCCTGAGACAGGGCGGCCTGGTCATGCAGAACTACAGAC

TGATTGACGCCACCCTGTACGTGACATTCGAGCCTTGCGTGATGTGCGCCGGCGC

CATGATCCACTCTAGGATCGGCCGCGTGGTGTTTGGCGTGAGGAACTCAAAAAG

AGGCGCCGCAGGCTCCCTGATGAACGTGCTGAACTACCCCGGCATGAATCACCG

CGTCGAAATTACCGAGGGAATCCTGGCAGATGAATGTGCCGCCCTGCTGTGCGA

TTTCTATCGGATGCCTAGACAGGTGTTCAATGCTCAGAAGAAGGCCCAGAGCTCC ATCAACTCCGGAGGATCTAGCGGAGGCTCCTCTGGCTCTGAGACACCTGGCACA

AGCGAGAGCGCAACACCTGAAAGCAGCGGGGGCAGCAGCGGGGGGTCAGACAA

GAAGTACAGCATCGGCCTGGCCATCGGCACCAACTCTGTGGGCTGGGCCGTGAT

CACCGACGAGTACAAGGTGCCCAGCAAGAAATTCAAGGTGCTGGGCAACACCGA

CCGGCACAGCATCAAGAAGAACCTGATCGGAGCCCTGCTGTTCGACAGCGGCGA

AACAGCCGAGGCCACCCGGCTGAAGAGAACCGCCAGAAGAAGATACACCAGAC

GGAAGAACCGGATCTGCTATCTGCAAGAGATCTTCAGCAACGAGATGGCCAAGG

TGGACGACAGCTTCTTCCACAGACTGGAAGAGTCCTTCCTGGTGGAAGAGGATA

AGAAGCACGAGCGGCACCCCATCTTCGGCAACATCGTGGACGAGGTGGCCTACC

ACGAGAAGTACCCCACCATCTACCACCTGAGAAAGAAACTGGTGGACAGCACCG

ACAAGGCCGACCTGCGGCTGATCTATCTGGCCCTGGCCCACATGATCAAGTTCCG

GGGCCACTTCCTGATCGAGGGCGACCTGAACCCCGACAACAGCGACGTGGACAA

GCTGTTCATCCAGCTGGTGCAGACCTACAACCAGCTGTTCGAGGAAAACCCCATC

AACGCCAGCGGCGTGGACGCCAAGGCCATCCTGTCTGCCAGACTGAGCAAGAGC

AGACGGCTGGAAAATCTGATCGCCCAGCTGCCCGGCGAGAAGAAGAATGGCCTG

TTCGGAAACCTGATTGCCCTGAGCCTGGGCCTGACCCCCAACTTCAAGAGCAACT

TCGACCTGGCCGAGGATGCCAAACTGCAGCTGAGCAAGGACACCTACGACGACG

ACCTGGACAACCTGCTGGCCCAGATCGGCGACCAGTACGCCGACCTGTTTCTGGC

CGCCAAGAACCTGTCCGACGCCATCCTGCTGAGCGACATCCTGAGAGTGAACAC

CGAGATCACCAAGGCCCCCCTGAGCGCCTCTATGATCAAGAGATACGACGAGCA

CCACCAGGACCTGACCCTGCTGAAAGCTCTCGTGCGGCAGCAGCTGCCTGAGAA

GTACAAAGAGATTTTCTTCGACCAGAGCAAGAACGGCTACGCCGGCTACATTGA

CGGCGGAGCCAGCCAGGAAGAGTTCTACAAGTTCATCAAGCCCATCCTGGAAAA

GATGGACGGCACCGAGGAACTGCTCGTGAAGCTGAACAGAGAGGACCTGCTGCG

GAAGCAGCGGACCTTCGACAACGGCAGCATCCCCCACCAGATCCACCTGGGAGA

GCTGCACGCCATTCTGCGGCGGCAGGAAGATTTTTACCCATTCCTGAAGGACAAC

CGGGAAAAGATCGAGAAGATCCTGACCTTCCGCATCCCCTACTACGTGGGCCCTC

TGGCCAGGGGAAACAGCAGATTCGCCTGGATGACCAGAAAGAGCGAGGAAACC

ATCACCCCCTGGAACTTCGAGGAAGTGGTGGACAAGGGCGCTTCCGCCCAGAGC

TTCATCGAGCGGATGACCAACTTCGATAAGAACCTGCCCAACGAGAAGGTGCTG

CCCAAGCACAGCCTGCTGTACGAGTACTTCACCGTGTATAACGAGCTGACCAAA

GTGAAATACGTGACCGAGGGAATGAGAAAGCCCGCCTTCCTGAGCGGCGAGCAG

AAAAAGGCCATCGTGGACCTGCTGTTCAAGACCAACCGGAAAGTGACCGTGAAG CAGCTGAAAGAGGACTACTTCAAGAAAATCGAGTGCTTCGACTCCGTGGAAATC

TCCGGCGTGGAAGATCGGTTCAACGCCTCCCTGGGCACATACCACGATCTGCTGA

AAATTATCAAGGACAAGGACTTCCTGGACAATGAGGAAAACGAGGACATTCTGG

AAGATATCGTGCTGACCCTGACACTGTTTGAGGACAGAGAGATGATCGAGGAAC

GGCTGAAAACCTATGCCCACCTGTTCGACGACAAAGTGATGAAGCAGCTGAAGC

GGCGGAGATACACCGGCTGGGGCAGGCTGAGCCGGAAGCTGATCAACGGCATCC

GGGACAAGCAGTCCGGCAAGACAATCCTGGATTTCCTGAAGTCCGACGGCTTCG

CCAACAGAAACTTCATGCAGCTGATCCACGACGACAGCCTGACCTTTAAAGAGG

ACATCCAGAAAGCCCAGGTGTCCGGCCAGGGCGATAGCCTGCACGAGCACATTG

CCAATCTGGCCGGCAGCCCCGCCATTAAGAAGGGCATCCTGCAGACAGTGAAGG

TGGTGGACGAGCTCGTGAAAGTGATGGGCCGGCACAAGCCCGAGAACATCGTGA

TCGAAATGGCCAGAGAGAACCAGACCACCCAGAAGGGACAGAAGAACAGCCGC

GAGAGAATGAAGCGGATCGAAGAGGGCATCAAAGAGCTGGGCAGCCAGATCCT

GAAAGAACACCCCGTGGAAAACACCCAGCTGCAGAACGAGAAGCTGTACCTGTA

CTACCTGCAGAATGGGCGGGATATGTACGTGGACCAGGAACTGGACATCAACCG

GCTGTCCGACTACGATGTGGACCATATCGTGCCTCAGAGCTTTCTGAAGGACGAC

TCCATCGACAACAAGGTGCTGACCAGAAGCGACAAGAACCGGGGCAAGAGCGA

CAACGTGCCCTCCGAAGAGGTCGTGAAGAAGATGAAGAACTACTGGCGGCAGCT

GCTGAACGCCAAGCTGATTACCCAGAGAAAGTTCGACAATCTGACCAAGGCCGA

GAGAGGCGGCCTGAGCGAACTGGATAAGGCCGGCTTCATCAAGAGACAGCTGGT

GGAAACCCGGCAGATCACAAAGCACGTGGCACAGATCCTGGACTCCCGGATGAA

CACTAAGTACGACGAGAATGACAAGCTGATCCGGGAAGTGAAAGTGATCACCCT

GAAGTCCAAGCTGGTGTCCGATTTCCGGAAGGATTTCCAGTTTTACAAAGTGCGC

GAGATCAACAACTACCACCACGCCCACGACGCCTACCTGAACGCCGTCGTGGGA

ACCGCCCTGATCAAAAAGTACCCTAAGCTGGAAAGCGAGTTTGTGTACGGCGAC

TACAAGGTGTACGACGTGCGGAAGATGATCGCCAAGAGCGAGCAGGAAATCGG

CAAGGCTACCGCCAAGTACTTCTTCTACAGCAACATCATGAACTTTTTCAAGACC

GAGATTACCCTGGCCAACGGCGAGATCCGGAAGCGGCCTCTGATCGAGACAAAC

GGCGAAACCGGGGAGATCGTGTGGGATAAGGGCCGGGATTTTGCCACCGTGCGG

AAAGTGCTGAGCATGCCCCAAGTGAATATCGTGAAAAAGACCGAGGTGCAGACA

GGCGGCTTCAGCAAAGAGTCTATCCTGCCCAAGAGGAACAGCGATAAGCTGATC

GCCAGAAAGAAGGACTGGGACCCTAAGAAGTACGGCGGCTTCGACAGCCCCACC

GTGGCCTATTCTGTGCTGGTGGTGGCCAAAGTGGAAAAGGGCAAGTCCAAGAAA CTGAAGAGTGTGAAAGAGCTGCTGGGGATCACCATCATGGAAAGAAGCAGCTTC

GAGAAGAATCCCATCGACTTTCTGGAAGCCAAGGGCTACAAAGAAGTGAAAAAG

GACCTGATCATCAAGCTGCCTAAGTACTCCCTGTTCGAGCTGGAAAACGGCCGG

AAGAGAATGCTGGCCTCTGCCGGCGAACTGCAGAAGGGAAACGAACTGGCCCTG

CCCTCCAAATATGTGAACTTCCTGTACCTGGCCAGCCACTATGAGAAGCTGAAGG

GCTCCCCCGAGGATAATGAGCAGAAACAGCTGTTTGTGGAACAGCACAAGCACT

ACCTGGACGAGATCATCGAGCAGATCAGCGAGTTCTCCAAGAGAGTGATCCTGG

CCGACGCTAATCTGGACAAAGTGCTGTCCGCCTACAACAAGCACCGGGATAAGC

CCATCAGAGAGCAGGCCGAGAATATCATCCACCTGTTTACCCTGACCAATCTGGG

AGCCCCTGCCGCCTTCAAGTACTTTGACACCACCATCGACCGGAAGAGGTACACC

AGCACCAAAGAGGTGCTGGACGCCACCCTGATCCACCAGAGCATCACCGGCCTG

TACGAGACACGGATCGACCTGTCTCAGCTGGGAGGTGACTCTGGCGGCTCAAAA

AGAACCGCCGACGGCAGCGAATTCGAGCCCAAGAAGAAGAGGAAAGTCTGAGA

TCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAGCCCCTTGAGCATCTG

ACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGTGTGTTGGAATTTTTT

GTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCATTTAAAACATCAGAA

TGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGCTGGCTGCCATGAAC

AAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGCCCCCTGCTGTCCATT

CCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTTTTTATATTTTGTTTT

GTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACATGTTTTACTAGCCAGA

TTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCCTCTTCTCTTATGGAG

ATCCCTCGACGGATCGGCCGCAATTCGTAACCATGTCATAGCTGTTTCCTGTGTG

AAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTG

TAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCA

CTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCC

AACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCAC

TGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAG

GCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGA

GCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTT

TTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAG

AGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGC

TCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTT

TCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTT CGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCC

CGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACAC

GACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTAT

GTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGA

AGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAG

TTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGT

TTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGAT

CTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTG

GTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAA

GTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATG

CTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTG

CCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCC

CAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCA

ATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCC

GCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAG

TTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTC

GTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACA

TGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTG

TCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAA

TTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAA

CCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTC

AATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGG

AAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGT

TCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAG

CGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAA

GGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAG

CATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAA

AATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTG

TAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTT

TTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACC

GAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAAC

GTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTA

CGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAA ATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGA

ACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTG

GCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCG

CCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGG

CGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCT

GCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAA

ACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTC

CACCGCGGTGGCGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCAT

ATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACAT

TGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCC

CATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACC

GCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACG

CCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCC

ACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAA

TGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTT

CCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGT

TTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAG

TCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGAC

TTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTG

TACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTG

GAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAG

CCTCCGGTCGACCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGT

TCTTTCTTTTTCGCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAG

GGTGTTGTTTAGAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAA

TTTTGTTTCTTTCACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTT

CATTTTCTGTAACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAAT

TCACTTTTGTTTATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAG

GCAATCAGGGTATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTAT

AATTAAATGATAAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAAT

ATTCTTATTGGTAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATG

GTTACAATGATATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCG

GGCCCCTCTGCTAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAA CGTGCTGGTTGTTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGAGGGCCGG ATCCGAATTCCTGTATTTGTCTGAAAAC (SEQ ID NO: 3)

[001170] In some embodiments, the MLV gag-cargo protein has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequences of SEQ ID NO:s. 3.

[001171] pCMV-VSVG

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG

CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC

GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC

TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGC AAGTTCACCATAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTT

CTAATTACCATTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAAT

AGGCACAGCCTTACAAGTCAAAATGCCCAAGAGTCACAAGGCTATTCAAGCAGA

CGGTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATG

GACCGAAGTATATAACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATG

CAAGGAAAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCC

TCCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAG

GTGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCAC

AGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTAC

AACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCC

ATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAG

GGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGC

AAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTC

GAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAG

GGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGA

CGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAG

AGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCA

GGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCA

GATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGAT

CAGTGGAACTACCACAGAAAGGGAACTGTGGGATGACTGGGCACCATATGAAGA

CGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCT

TTATACATGATTGGACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGG

CTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGA

TGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTA

GAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGG

GTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAAT

TAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTG

GAAAGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTT

GTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAA

AAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCA

GGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCA

CAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAG

CCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGT GTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCAT TTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGC TGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGC CCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTT TTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACAT GTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCC TCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATA GCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCC GGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTA ATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGC ATTAATGAATCGGCCAACGCGCGGGGA (SEQ ID NO: 4)

[001172] In some embodiments, the VSVG envelope glycoprotein has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequences of SEQ ID NO:s. 4.

[001173] pJAQ110_(pCMV-VSVG_mut)

GAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCG

CTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACG

GTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC

AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGC

TCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAA

ACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCG CTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGG

GAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGT

CGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGC

GCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGC

CACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTG

CTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATT

TGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCT

TGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGC

AGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG

GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATT

ATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTG

AGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCC

GTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAG

CCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATC

CAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTT

TGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGG

TATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCC

ATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTA

AGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCA

TTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGG

ATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTC

TTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAA

CCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGG

GTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACAC

GGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAG

GGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAA

TAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAAT

ATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATA

GGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTT

GAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAAC GTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA

CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTA

AAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGA

AAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGC

GGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGG

CGCGTCCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCG

GGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT

AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAG

TGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGAGCTCCACCGCGGTGG

CGGCCGCTCTAGAGAGCTTGGCCCATTGCATACGTTGTATCCATATCATAATATG

TACATTTATATTGGCTCATGTCCAACATTACCGCCATGTTGACATTGATTATTGAC

TAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAG

TTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACC

CCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGAC

TTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTA

CATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAAT

GGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCA

GTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTAC

ATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCA

TTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATG

TCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGA

GGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT

CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGGTCGA

CCGATCCTGAGAACTTCAGGGTGAGTTTGGGGACCCTTGATTGTTCTTTCTTTTTC

GCTATTGTAAAATTCATGTTATATGGAGGGGGCAAAGTTTTCAGGGTGTTGTTTA

GAATGGGAAGATGTCCCTTGTATCACCATGGACCCTCATGATAATTTTGTTTCTTT

CACTTTCTACTCTGTTGACAACCATTGTCTCCTCTTATTTTCTTTTCATTTTCTGTA

ACTTTTTCGTTAAACTTTAGCTTGCATTTGTAACGAATTTTTAAATTCACTTTTGTT

TATTTGTCAGATTGTAAGTACTTTCTCTAATCACTTTTTTTTCAAGGCAATCAGGG

TATATTATATTGTACTTCAGCACAGTTTTAGAGAACAATTGTTATAATTAAATGAT

AAGGTAGAATATTTCTGCATATAAATTCTGGCTGGCGTGGAAATATTCTTATTGG

TAGAAACAACTACACCCTGGTCATCATCCTGCCTTTCTCTTTATGGTTACAATGAT

ATACACTGTTTGAGATGAGGATAAAATACTCTGAGTCCAAACCGGGCCCCTCTGC TAACCATGTTCATGCCTTCTTCTCTTTCCTACAGCTCCTGGGCAACGTGCTGGTTG

TTGTGCTGTCTCATCATTTTGGCAAAGAATTCCTCGACGGATCCCTCGAGGAATT

CTGACACTATGAAGTGCCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGC

AAGTTCACCATAGTTTTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTT

CTAATTACCATTATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAAT

AGGCACAGCCTTACAAGTCAAAATGCCCCAGAGTCACAAGGCTATTCAAGCAGA

CGGTTGGATGTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATG

GACCGAAGTATATAACACATTCCATCCGATCCTTCACTCCATCTGTAGAACAATG

CAAGGAAAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCC

TCCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAG

GTGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCAC

AGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTCTAC

AACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCATTTCC

ATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGAAAGGAG

GGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGAGGCAAGGCCTGC

AAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCCCATCAGGTGTCTGGTTC

GAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTGAATGCCCAGAAG

GGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTAAGTCTAATTCAGGA

CGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAACCTGGAGCAAAATCAG

AGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATCTTGCTCCTAAAAACCCA

GGAACCGGTCCTGCTTTCACCATAATCAATGGTACCCTAAAATACTTTGAGACCA

GATACATCAGAGTCGATATTGCTGCTCCAATCCTCTCAAGAATGGTCGGAATGAT

CAGTGGAACTACCACAGAAGCGGAACTGTGGGATGACTGGGCACCATATGAAGA

CGTGGAAATTGGACCCAATGGAGTTCTGAGGACCAGTTCAGGATATAAGTTTCCT

TTATACATGATTGGACATGGTATGTTGGACTCCGATCTTCATCTTAGCTCAAAGG

CTCAGGTGTTCGAACATCCTCACATTCAAGACGCTGCTTCGCAACTTCCTGATGA

TGAGAGTTTATTTTTTGGTGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTA

GAAGGTTGGTTCAGTAGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGG

GTTAATCATTGGACTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAAT

TAAAGCACACCAAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTG

GAAAGTAACTCAAATCCTGCACAACAGATTCTTCATGTTTGGACCAAATCAACTT

GTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAA

AAAAAAAAAAAAAACGGAATTCCTCGAGGGATCCGTCGAGGAATTCACTCCTCA GGTGCAGGCTGCCTATCAGAAGGTGGTGGCTGGTGTGGCCAATGCCCTGGCTCA CAAATACCACTGAGATCTTTTTCCCTCTGCCAAAAATTATGGGGACATCATGAAG CCCCTTGAGCATCTGACTTCTGGCTAATAAAGGAAATTTATTTTCATTGCAATAGT GTGTTGGAATTTTTTGTGTCTCTCACTCGGAAGGACATATGGGAGGGCAAATCAT TTAAAACATCAGAATGAGTATTTGGTTTAGAGTTTGGCAACATATGCCCATATGC TGGCTGCCATGAACAAAGGTTGGCTATAAAGAGGTCATCAGTATATGAAACAGC CCCCTGCTGTCCATTCCTTATTCCATAGAAAAGCCTTGACTTGAGGTTAGATTTTT TTTATATTTTGTTTTGTGTTATTTTTTTCTTTAACATCCCTAAAATTTTCCTTACAT GTTTTACTAGCCAGATTTTTCCTCCTCTCCTGACTACTCCCAGTCATAGCTGTCCC TCTTCTCTTATGGAGATCCCTCGACGGATCGGCCGCAATTCGTAATCATGTCATA GCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCC GGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTA ATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGC

ATTAATGAATCGGCCAACGCGCGGGGA (SEQ ID NO: 5)

[001174] In some embodiments, the VSVG mutant has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequences of SEQ ID NO:s. 5.

Methods and uses thereof

[001175] Other aspects of the disclosure relate to one or more methods. In some embodiments, the methods are directed toward delivering any of the viral-like particle disclosed herein to a target cell comprising preparing any one of (1) the viral-like particles disclosed herein, (2) the one or more polynucleotides disclosed herein, (3) the one or more vectors disclosed herein or (4) the cells disclosed herein, and contacting a target cell with one or more of said compositions

[001176] Other aspects of the present disclosure relate to methods of preparing the eVLPs disclosed herein. Any suitable method for producing the eVLPs of the present disclosure may be used by the skilled artisan. For example, in some embodiments, methods for producing the presently described eVLPs comprise transfecting, transducing, electroporating, or otherwise inserting into a producer cell one or more polynucleotides that together encode all the components of the eVLPs (e.g., any of the pluralities of polynucleotides described herein). In some embodiments, the polynucleotides which are transfected, transduced, electroporated, or otherwise inserted into a producer cell comprise: (i) a first polynucleotide comprising a nucleic acid sequence encoding a viral envelope glycoprotein; (ii) a second polynucleotide comprising a nucleic acid sequence encoding a group -specific antigen (gag) protease (pro) polyprotein; (iii) a third polynucleotide comprising a nucleic acid sequence encoding a fusion protein, wherein the fusion protein comprises: (a) a group- specific antigen (gag) nucleocapsid protein; (b) a nucleic acid programmable DNA binding protein (napDNAbp); (c) a cleavable linker; and (d) a nuclear export sequence (NES); and (iv) a fourth polynucleotide comprising a nucleic acid sequence encoding a guide RNA (gRNA), wherein the gRNA binds to the napDNAbp of the fusion protein encoded by the third polynucleotide.

[001177] In some embodiments, once the producer cell expresses the polynucleotides, the various components of the eVLPs self-assemble spontaneously within the producer cells. Assembly of the eVLPs relies on multimerization of the gag polyproteins encoded on the polynucleotides as described above. The gag polyproteins (some of which are fused to a gene editing agent, such as a Cas9 protein, a base editor, or a prime editor) multimerize at the cell membrane of a producer cell and are subsequently released into the producer cell supernatant spontaneously. Thus, eVLPs may be produced by transient transfection of producer cells (for example, Gesicle Producer 293T cells) as described in the Examples herein. All of the polynucleotides required for production of the eVLPs may be transfected into the producer cells simultaneously, or each polynucleotide needed may be transfected one at a time. In some embodiments, a single polynucleotide encodes all the components needed to produce the eVLPs described herein. Pollowing transfection and incubation of the producer cells (e.g., for about 2 hours, about 3 hours, about 4 hours, about 5 hours, about 6 hours, about 7 hours, about 8 hours, about 9 hours, about 10 hours, about 15 hours, about 24 hours, about 36 hours, about 48 hours, or more than 48 hours), producer cell supernatant may be harvested, and eVLPs may be purified therefrom.

[001178] Any cell capable of expressing a foreign polynucleotide may be used to produce the eVLPs described herein. Lor example, the present disclosure contemplates the use of any of the cells listed in the Kits and Cells section herein for production of the eVLPs, or any other cell known in the art capable of expressing a foreign polynucleotide. In some embodiments, the producer cells are HEK Gesicle produce cells. In some embodiments, the producer cells are immune cells. In other embodiments, the cells are neural cells. In other embodiments still the cells are retinal pigment epithelium cells. . [001179] Overview of an embodiment of the manufacture of eVLPs comprising gene editing cargo in a producer cell using a set of expression plasmids which encode the various self-assembling components of the eVLPs: (a) plasmid encoding a Gag-BE fusion protein (e.g., a retroviral Gag, MMLV-Gag-BE fusion protein); (b) plasmid encoding a Gag-Pro-Pol protein (e.g., a retroviral proteins, such as a MMLV protease precursor); (c) a plasmid encoding a BE sgRNA; and (d) a plasmid encoding an envelope glycoprotein (e.g., the spike glycoprotein of the vesicular stomatitis virus (VSV-G)). The plasmids are transiently cotransfected into the producer cell and the encoded protein and sgRNA products are encoded. In some embodiments, such as the fourth-generation eVLPs described herein, the inventors found an optimized stoichiometry ratio of Gag-cargo fusion to Gag-Pro-Pol fusion protein which balances the amount of Gag-cargo available to be packaged into VLPs with the amount of retrovirus protease (the “Pro” in the Gag-Pro-Pol fusion) required for VLP maturation. In one embodiment, the optimized ratio of Gag-cargo fusion to Gag-Pro-Pol fusion protein is achieved by the appropriate ratio of plasmids encoding each component which are transiently delivered to the producer cells. In one embodiment, to modulate the stoichiometry of the Gag-cargo fusion to Gag-Pro-Pol fusion, the ratio of the plasmid encoding Gag-cargo (e.g., Gag-3 xNES-ABE8e) to wild-type MMLV gag-pro-pol plasmids transfected for VLP production was varied.

[001180] Other methods are directed to methods of editing a nucleic acid molecule in a target cell using any of the eVLPs disclosed herein. In some embodiments the methods comprise contacting the target cell with any of the eVLPs, polynucleotides, vectors, and/or cells disclosed herein, wherein the eVLPs encapsulate a gene editor (e.g., base editor or prime editor), and wherein upon transduction the gene editor installs one or more modifications to the nucleic acid molecule at a target site. The eVLPs disclosed herein may be used to edit any suitable nucleic acid in any suitable target cell known to an artisan of ordinary skill in the art. In some embodiments, the target cell is a mammalian cell (e.g., a human cell). In certain embodiments, the target cell is a human cell. However, other target cells are possible other embodiments. Lor example, in some embodiments, the target cell is a plant cell.

[001181] In some embodiments, the target cell is in a subject (e.g., a human). In certain embodiments, the subject is a human. However, the subject may be any mammalian species, such as dog, cat, sheep, cow, camel, horse, goat, and the like, according to some embodiments. [001182] As described in more detail above, the methods, according to some embodiments, install one or more modifications to the nucleic acid molecule at a target site. Without wishing to be bound by theory, it is believed that installation of the one or more modifications to the nucleic acid molecule are associated with reducing, relieving, or preventing the symptoms of a disease or disorder. Any disease or disorder capable of being treated using the methods disclosed herein are herein contemplated. For example, in some embodiments, the disease or disorder is a central nervous system (CNS) disease or disorder. In other embodiments, the disease or disorder is a liver disease or disorder. In other embodiments still, the disease or disorder is an ocular disease or disorder.

[001183] In other embodiments, the methods comprise treating a disease by gene editing using the eVLPs disclosed herein. In some embodiments, the methods comprise contacting a target cell any of the eVLPs, polynucleotides, vectors, and/or cells disclosed herein, wherein the eVLPs encapsulate a gene editor (e.g., base editor or prime editor), and wherein upon transduction the gene editor installs one or more modifications to the nucleic acid molecule at a target site, and wherein the one or more modifications are associated with reducing, relieving, or preventing the symptoms of a disease or disorder. In some embodiments, the disease or disorder is a central nervous system (CNS) disease or disorder. In other embodiments, the disease or disorder is a liver disease or disorder. In other embodiments still, the disease or disorder is an ocular disease or disorder.

[001184] In other embodiments, the methods are directed toward treating a disease comprising contacting a target cell with the eVLPs, polynucleotides, and/or vectors disclsosed herein. In some embodiments, the cargo encapsulated within the eVLPs is a therapeutic intended to reduce, relieve, cure or prevent the symptoms of a disease or disorder.

Pharmaceutical compositions

[001185] Other aspects of the present disclosure relate to pharmaceutical compositions comprising any of the VLPs, nucleocapsid protein variants, polynucleotides, and vectors provided herein. The term “pharmaceutical composition,” as used herein, refers to a composition formulated for pharmaceutical use. In some embodiments, the pharmaceutical composition further comprises a pharmaceutically acceptable carrier. In some embodiments, the pharmaceutical composition comprises additional agents (e.g., for specific delivery, increasing half-life, or other therapeutic compounds).

[001186] As used here, the term “pharmaceutically-acceptable carrier” means a pharmaceutically-acceptable material, composition or vehicle, such as a liquid or solid filler, diluent, excipient, manufacturing aid (e.g., lubricant, talc magnesium, calcium or zinc stearate, or steric acid), or solvent encapsulating material, involved in carrying or transporting the compound from one site (e.g., the delivery site) of the body, to another site (e.g., organ, tissue or portion of the body). A pharmaceutically acceptable carrier is “acceptable” in the sense of being compatible with the other ingredients of the formulation and not injurious to the tissue of the subject (e.g., physiologically compatible, sterile, physiologic pH, etc.). Some examples of materials which can serve as pharmaceutically-acceptable carriers include: (1) sugars, such as lactose, glucose and sucrose; (2) starches, such as corn starch and potato starch; (3) cellulose, and its derivatives, such as sodium carboxymethyl cellulose, methylcellulose, ethyl cellulose, microcrystalline cellulose and cellulose acetate; (4) powdered tragacanth; (5) malt; (6) gelatin; (7) lubricating agents, such as magnesium stearate, sodium lauryl sulfate and talc; (8) excipients, such as cocoa butter and suppository waxes; (9) oils, such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; (10) glycols, such as propylene glycol; (11) polyols, such as glycerin, sorbitol, mannitol and polyethylene glycol (PEG); (12) esters, such as ethyl oleate and ethyl laurate; (13) agar; (14) buffering agents, such as magnesium hydroxide and aluminum hydroxide; (15) alginic acid; (16) pyrogen-free water; (17) isotonic saline; (18) Ringer's solution; (19) ethyl alcohol; (20) pH buffered solutions; (21) polyesters, polycarbonates and/or poly anhydrides; (22) bulking agents, such as polypeptides and amino acids; (23) serum component, such as serum albumin, HDL and LDL; (22) C2-C12 alcohols, such as ethanol; and (23) other non-toxic compatible substances employed in pharmaceutical formulations. Wetting agents, coloring agents, release agents, coating agents, sweetening agents, flavoring agents, perfuming agents, preservatives, and antioxidants can also be present in the formulation. The terms such as “excipient”, “carrier”, “pharmaceutically acceptable carrier” or the like are used interchangeably herein.

[001187] In some embodiments, the pharmaceutical composition is formulated for delivery to a subject, e.g., for delivering a gene editing agent using a VLP. Suitable routes of administrating the pharmaceutical composition described herein include, without limitation: topical, subcutaneous, transdermal, intradermal, intralesional, intraarticular, intraperitoneal, intravesical, transmucosal, gingival, intradental, intracochlear, transtympanic, intraorgan, epidural, intrathecal, intramuscular, intravenous, intravascular, intraosseus, periocular, intratumoral, intracerebral, and intracerebroventricular administration. [001188] In some embodiments, the pharmaceutical composition described herein is administered locally to a diseased site (e.g., tumor site). In some embodiments, the pharmaceutical composition described herein is administered to a subject by injection, by means of a catheter, by means of a suppository, or by means of an implant, the implant being of a porous, non-porous, or gelatinous material, including a membrane, such as a sialastic membrane, or a fiber.

[001189] In another aspect, an article of manufacture containing VLPs and/or other materials useful for the treatment of the diseases is provided. In some embodiments, the article of manufacture comprises a container and a label. Suitable containers include, for example, bottles, vials, syringes, and test tubes. The containers may be formed from a variety of materials such as glass or plastic. In some embodiments, the container holds a composition that is effective for treating a disease and may have a sterile access port. For example, the container may be an intravenous solution bag or a vial having a stopper pierce-able by a hypodermic injection needle. The active agent in the composition is a compound of the invention. In some embodiments, the label on or associated with the container indicates that the composition is used for treating the disease of choice. The article of manufacture may further comprise a second container comprising a pharmaceutically-acceptable buffer, such as phosphate-buffered saline, Ringer's solution, or dextrose solution. It may further include other materials desirable from a commercial and user standpoint, including other buffers, diluents, filters, needles, syringes, and package inserts with instructions for use.

Kits and cells

[001190] The VLPs, libraries, nucleocapsid protein variants, polynucleotides, and vectors of the present disclosure may be assembled into kits. In some embodiments, the kit comprises polynucleotides for expression and assembly of the VLPs described herein. In other embodiments, the kit comprises VLP libraries as described herein.

[001191] The kits described herein may include one or more containers housing components for performing the methods described herein, and optionally instructions for use. Any of the kits described herein may further comprise components needed for producing or delivering VLPs as described herein. Each component of the kits, where applicable, may be provided in liquid form (e.g., in solution) or in solid form, (e.g., a dry powder). In certain cases, some of the components may be reconstitutable or otherwise processible (e.g., to an active form), for example, by the addition of a suitable solvent or other species (for example, water), which may or may not be provided with the kit. [001192] In some embodiments, the kits may optionally include instructions and/or promotion for use of the components provided. As used herein, “instructions” can define a component of instruction and/or promotion, and typically involve written instructions on or associated with packaging of the disclosure. Instructions also can include any oral or electronic instructions provided in any manner such that a user will clearly recognize that the instructions are to be associated with the kit, for example, audiovisual (e.g., videotape, DVD, etc.), Internet, and/or web-based communications, etc. The written instructions may be in a form prescribed by a governmental agency regulating the manufacture, use, or sale of pharmaceuticals or biological products, which can also reflect approval by the agency of manufacture, use or sale for animal administration. As used herein, “promoted” includes all methods of doing business including methods of education, hospital and other clinical instruction, scientific inquiry, drug discovery or development, academic research, pharmaceutical industry activity including pharmaceutical sales, and any advertising or other promotional activity including written, oral and electronic communication of any form, associated with the disclosure. Additionally, the kits may include other components depending on the specific application, as described herein.

[001193] The kits may contain any one or more of the components described herein in one or more containers. The components may be prepared sterilely, packaged in a syringe, and shipped refrigerated. Alternatively, they may be housed in a vial or other container for storage. A second container may have other components prepared sterilely. Alternatively, the kits may include the active agents premixed and shipped in a vial, tube, or other container. [001194] The kits may have a variety of forms, such as a blister pouch, a shrink-wrapped pouch, a vacuum sealable pouch, a sealable thermoformed tray, or a similar pouch or tray form, with the accessories loosely packed within the pouch, one or more tubes, containers, a box, or a bag. The kits may be sterilized after the accessories are added, thereby allowing the individual accessories in the container to be otherwise unwrapped. The kits can be sterilized using any appropriate sterilization techniques, such as radiation sterilization, heat sterilization, or other sterilization methods known in the art. The kits may also include other components, depending on the specific application, for example, containers, cell media, salts, buffers, reagents, syringes, needles, a fabric, such as gauze, for applying or removing a disinfecting agent, disposable gloves, a support for the agents prior to administration, etc. Some aspects of this disclosure provide kits comprising a nucleic acid construct comprising a nucleotide sequence encoding the various components of the VLPs described herein (e.g., including, but not limited to, the cargo, gag proteins, gRNAs, and viral envelope glycoproteins). In some embodiments, the nucleotide sequence(s) comprises a heterologous promoter (or more than a single promoter) that drives expression of the VLP system components. In some embodiments, the kit comprises a VLP library, or a library of cells comprising a VLP library.

[001195] Other aspects of this disclosure provide kits comprising one or more nucleic acid constructs encoding the various components of the VLPs described herein. In some embodiments, the nucleotide sequence comprises a heterologous promoter that drives expression of the VLP system components.

[001196] Cells that may contain any of the VLPs, libraries, nucleocapsid protein variants, polynucleotides, and vectors described herein include prokaryotic cells and eukaryotic cells. In various aspects relating to the production of VLPs, the disclosure provides for any suitable cells for use as a VLP-producer cell line, i.e., the cell line that in various embodiments becomes transiently transformed with the plasmids encoding the protein and nucleic acid components of the VLPs. In various other aspects relating to applications of VLPs, the disclosure provides for any suitable target or recipient cells, e.g., a diseased cell or tissue in a subject in need of treatment by way of base editing or prime editing as delivered by a VLP. The methods described herein may be used to deliver a cargo such as a base editor or prime editor into a eukaryotic cell (e.g., a mammalian cell, such as a human cell). In some embodiments, the cell is in vitro e.g., cultured cell). In some embodiments, the cell is in vivo (e.g., in a subject such as a human subject). In some embodiments, the cell is ex vivo (e.g., isolated from a subject and may be administered back to the same or a different subject).

[001197] Examples of cell lines include, but are not limited to, C8161, CCRF-CEM, MOLT, mIMCD-3, NHDF, HeLa-S3, Huhl, Huh4, Huh7, HUVEC, HASMC, HEKn, HEKa, MiaPaCell, Panel, PC-3, TF1, CTLL-2, C1R, Rat6, CV1, RPTE, A10, T24, J82, A375, ARH-77, Calul, SW480, SW620, SKOV3, SK-UT, CaCo2, P388D1, SEM-K2, WEHI-231, HB56, TIB55, Jurkat, J45.01, LRMB, Bcl-1, BC-3, IC21, DLD2, Raw264.7, NRK, NRK- 52E, MRC5, MEF, Hep G2, HeLa B, HeLa T4, COS, COS-1, COS-6, COS-M6A, BS-C-1 monkey kidney epithelial, BALB/3T3 mouse embryo fibroblast, 3T3 Swiss, 3T3-L1, 132-d5 human fetal fibroblasts; 10.1 mouse fibroblasts, 293-T, 3T3, 721, 9L, A2780, A2780ADR, A2780cis, A 172, A20, A253, A431, A-549, ALC, B16, B35, BCP-1 cells, BEAS-2B, bEnd.3, BHK-21, BR 293. BxPC3. C3H-10T1/2, C6/36, Cal-27, CHO, CHO-7, CHO-IR, CHO-K1, CHO-K2, CHO-T, CHO Dhfr

COR-L23/R23, COS-7, COV-434, CML Tl, CMT, CT26, D17, DH82, DU145, DuCaP, EL4, EM2, EM3, EMT6/AR1, EMT6/AR10.0, FM3, H1299, H69, HB54, HB55, HCA2, HEK-293, HeLa, Hepalclc7, HL-60, HMEC, HT-29, Jurkat, JY cells, K562 cells, Ku812, KCL22, KG1, KYO1, LNCap, Ma-Mel 1-48, MC-38, MCF-7, MCF-10A, MDA-MB-231, MDA-MB-468, MDA-MB-435, MDCK II, MDCK 11, MOR/0.2R, MONO-MAC 6, MEDIA, MyEnd, NCI-H69/CPR, NCI-H69/LX10, NCI-H69/LX20, NCI-H69/LX4, NIH-3T3, NALM-1, NW- 145, OPCN/OPCT cell lines, Peer, PNT-1A/PNT 2, RenCa, RIN-5F, RMA/RMAS, Saos-2 cells, Sf-9, SkBr3, T2, T-47D, T84, THP1 cell line, U373, U87, U937, VCaP, Vero cells, WM39, WT-49, X63, YAC-1, YAR, and transgenic varieties thereof. Other cells contemplated herein include primary cells (e.g., isolated directly from tissue) and/or primary cell lines. Exemplary primary cells include immune cells, neural cells, or retinal pigment epithelium cells.

[001198] The function and advantage of these and other embodiments of the present invention will be more fully understood from the Examples below. The following Examples are intended to illustrate the benefits of the present invention and to describe particular embodiments, but are not intended to exemplify the full scope of the invention. Accordingly, it will be understood that the Examples are not meant to limit the scope of the invention.

EXAMPLES

Example 1, Cloning

[001199] All plasmids used in herein were cloned using USER cloning. Plasmid DNA was PCR-amplified using PhusionUGreen Multiplex PCR Master Mix (Thermo Fisher Scientific). Maehl (Thermo Fisher Scientific) and Stbl3 (New England Biolabs) chemically competent E. coli were used for plasmid propagation.

Example 2, Cell culture conditions

[001200] Gesicle Producer 293T cells (Takara; 632617) were maintained in DMEM + GlutaMAX (Life Technologies) supplemented with 10% (v/v) fetal bovine serum. Primary human CD34 cells were maintained in serum- free X-VIVO-15 media (Lonza) and supplemented with lOOng/mL recombinant human SCF (R&D Systems; 255-SC/CF) or 1 microM 740Y-P (R&D Systems; 1983), TPO (R&D Systems; 299-TP/CF), and Flt3 (R&D Systems; 308-FK/CF). Cells were cultured at 37°C with 5% carbon dioxide and were confirmed to be negative for mycoplasma by testing with Myco Alert (Lonza Biologies).

Example 3. BE-eVLP production and purification [001201] BE-eVLPs were produced by transient transfection of Gesicle Producer 293T cells. Gesicle cells were seeded in T-75 flasks (Coming) at a density of 5xl0⁶ cells per flask. After 20-24 h, cells were transfected using the jetPRIME transfection reagent (Polyplus) according to the manufacturer’s protocols. For producing v4 BE-eVLPs, a mixture of plasmids expressing VSVG (400 ng), MMLVgag-pro-pol (3,375 ng), MMLVgag-3xNES- ABE8e (1,125 ng), and an sgRNA (4,400 ng) were co-transfected per T-75 flask. For producing targeted BE-eVLPs, rather than 400 ng of VSVG, 300 ng of VSVGmut or VSVG plus 900 ng of the targeting protein construct were transfected. For azido-eVLPs, producer cells supernatant was injected with a final concentration of 50 mM N- Azidoacetylmannosamine-tetraacylated (Ac4ManNAz) (Sigma Aldrich; 900917) ten minutes prior to plasmid transfection.

[001202] 40-48 h post-transfection, producer cell supernatant was harvested and centrifuged for 5 min at 500 g to remove cell debris. The clarified eVLP-containing supernatant was filtered through a 0.45-mm PVDF filter. For azido-eVLPs the clarified supernatant was reacted with lOOmg/mL of specified cell-targeting DBCO-conjugated antibody or 20mM DBCO-conjugated small molecule and reacted for 1 h (37 °C). The supernatant was concentrated 1000-3000-fold by ultracentrifugation using a cushion of 20% (w/v) sucrose in PBS. Ultracentrifugation was performed at 26,000 rpm for 2 h (4°C) using an SW28 rotor in an Optima XPN Ultracentrifuge (Beckman Coulter). Following ultracentrifugation, BE-eVLP pellets were resuspended in cold PBS (pH 7.4) and centrifuged at 1,000 g for 5 min to remove debris. BE-eVLPs were frozen at a rate of -l°C/min and stored at -80°C. BE-eVLPs were thawed on ice immediately prior to use.

[001203]

Example 4, BE-eVLP transduction in CD34+ cell culture and genomic DNA isolation [001204] Cryopreserved primary human CD34+ cells were thawed rapidly and plated at a density of 1E6 cells/mL and a volume of 50 microL per well in 96-well plates. Subsequently, BE-eVLPs were added directly to the culture media in each well at an multiplicity of infection of between 2E5-2E6 VLP/cell. 12 hrs post-transduction, cells were diluted with 100 microL of X-VIVO-15 media plus cytokines. Cells were again diluted with 100 microL of media and transferred into 48 well plates 48 h post transduction. After a total time course of 96 hrs, cells were briefly washed once with PBS and lysed in 50 microL of lysis buffer (lOmM Tris-HCl pH 8.0, 0.05% SDS, 25 microg/mL Proteinase K (Thermo Fisher Scientific)) at 37 °C for 1 hr followed by heat inactivation of Proteinase K at 80 °C for 30 min.

Example 5. BE-eVLP transduction in CD34+/HEK293T cell culture

[001205] HEK293T cells were seeded in a 48-well plate (Coming) at 1.2xl0⁵ cells per well in 250 microL DMEM supplemented with 10% fetal bovine serum. 20-24 hr after seeding, cryopreserved human CD34+ cells were thawed and resuspended in at 3xl0⁵ cells/mL of X- VIVO-15 media plus cytokines. Then, DMEM was aspirated from HEK293T cells, cells were washed briefly with PBS, and 100 microL of the CD34+ cell suspension was added to each treatment well of the 96-well plate. The eVLPs were added directly to each well. 12 hrs posttransduction, cells were diluted with 150 microL of X- VIVO- 15 media plus cytokines. Cells were again diluted with an additional 150 microL of media 48 hr post transduction.

[001206] 72 hr post-transduction, cells were washed, reacted with an antibody cocktail of anti-hCD34 (Biolegend; clone 581; cat 34511) and anti-hCD51 (Biolegend; clone NKI-M9; cat 327916) to separate CD34+ cells from HEK293T cells (CD51+) by FACS. The genomic DNA of the separated cells were isolated as described above.

Example 6. High-throughput sequencing of genomic DNA

[001207] Following genomic DNA isolation, 1 microL of the isolated DNA (1-10 nanog) was used as input for the first of two PCR reactions. Genomic loci were amplified in PCR1 using PhusionU polymerase (Thermo Fisher Scientific). PCR1 primers for the BCL11A genomic locus are:

[001208] PCR1 was performed as follows: 95 °C for 3 min; 30-32 cycles of 95 °C for 15 s, 61 °C for 20 s, and 72 °C for 30 s; 72 °C for 2 min. PCR1 products were confirmed on a 1.5% agarose gel. ImicroL PCR1 was used as input for PCR2 to install the Illumina barcodes. PCR2 was conducted for 9 cycles using Phusion HS II kit (Life Technologies). Following PCR2, samples were pooled and gel purified in a 1% agarose gel using a Qiaquick Gel Extraction Kit (Qiagen). Library concentration was determined by Qubit High-Sensitivity Assay Kit (Thermo Fisher Scientific). Samples were sequenced on an Illumina Miseq instrument (paired-end read, read 1: 250-300 cycles, read 2: 0 cycles) using an illumine Miseq 300 v2 Kit (Illumina).

Example 7, High-throughput sequencing data analysis

[001209] Sequencing reads were demultiplexed using the MiSeq Reporter software (Illumina) and were analyzed using CRISPResso2 (Clementet al., 2019) as previously described (Doman et al., 2020). Batch analysis mode (one batch for each unique amplicon and sgRNA combination analyzed) was used in all cases. Reads were filtered by minimum average quality score (Q > 30) prior to analysis. Base editing efficiencies are reported as the percentage of sequencing reads containing a given base conversion at a specific position. Prism 9 (GraphPad) was used to generate dot plots and bar plots.

Example 8. BE-eVLP protein content quantification

[001210] For protein quantification, BE-eVLPs were lysed in Laemmli sample buffer as described above. The concentration of BE protein in purified BE-eVLPs was quantified using the FastScan™ Cas9 (S. pyogenes) ELISA kit (Cell Signaling Technology; 29666C) according to the manufacturer’s protocols. Recombinant Cas9 (.S'. pyogenes) nuclease protein (New England Biolabs; M0386) was used to generate the standard curve for quantification. A copy number of 50 molecules of BE per eVLP was used to determine eVLP titers.

Example 9. Prime editing eVLP production

[001211] eVLPs were produced as previously described. Gesicle 293T cells were plated at a density of 5E6 cells per flask in 10 ml of DMEM + 10% FBS media in T75 flask (Corning, 353136). A total of 18-24 h after seeding, a mixture of plasmids was transfected to producer cells with jetPRIME transfection reagent (Polyplus) following the manufacturer’s protocol. For production of v3 PE-eVLPs, plasmids expressing VSV-G (400 ng), wild-type MMLV Gag-Pol (2,813 ng), Gag-MCP-Pol (1,125 ng), Gag-PE (563 ng) and MS2-guide RNA (4,400 ng MS2-epegRNA for v3 PE2-eVLP, 3520 ng MS2-epegRNA and 880 ng MS2- ngRNA for v3 PE3-eVLP) were co-transfected to each T75 flask. For production of v3b PE- eVLPs, plasmids expressing VSV-G (400 ng), wild-type MMLV Gag-Pol (2,813 ng), Gag- COM-Pol (2,000 ng), Gag-P3-Pol (422 ng), P4-PE (422 ng) and COM-gRNAs (4,400 ng COM-epegRNA for v3b PE2-eVLP, 3,520 ng COM-epegRNA and 880 ng COM-ngRNA for v3b PE3-eVLP) were co-transfected to each T75 flask. A total of 40-48 h after transfection, supernatants were collected, centrifuged at 500g for 5 min and the supernatant was filtered through 0.45-pm PVDF filter. eVLPs were concentrated using a 20% (w/v) sucrose cushion solution via ultracentrifugation at 26,000 rpm for 2 h at 4 °C using an SW28 rotor in an Optima XPN Ultracentrifuge (Beckman Coulter). Following ultracentrifugation, eVLP pellets were resuspended in cold PBS solution. For short-term storage, eVLPs were stored at 4 °C for up to 1 week. For long-term storage, eVLPs were stored at -80 °C and thawed on ice immediately before use. Repeated freeze-thaw was avoided.

[001212] It is noted that PE efficiencies are typically much lower in the eVLP format. A similar edit is described in An et al. (see below) in which editing saturates at 30% in HEK293T cells. Such a drop from HEK293T cells to CD34+ cells is commonly seen for other edits as HEK293T cells are easier to genome edit.

Example 10, Barcoded lentiviral dictionary screens for targeted ligands

[001213] HEK clone 17 cells were seeded in 96-well plates at a density of 30k cells/well. After 20-24 hours cells were transfected with the following plasmid mixture: 20 ng Env., 60 ng targeting ligand, 40 ng psPAX2 lentiviral packaging plasmid, and 36 ng lentiviral genome encoding both a NNNNNNNNNNNNNNNNNNNN barcode and the CMV-EGFP-P2A- PuroR gene. Plasmids were prepared using PlasmidPlus Midi and Mini kits (Qiagen). Plasmids were mixed with 0.5 pF FuGENE 6 (Promega) to a final volume of 10 pL, incubated 10 min at room temperature, and added to each well.

[001214] 48 hours post-transfection, virus-containing supernatant was harvested and concentrated 1000-3000x by ultracentrifugation with a 20% sucrose cushion. Target cells were then transduced at a dose of 2-10 pL of virus into 100k cells. 5 days post-transduction, target cells were stained with relevant antibodies and sorted for GFP-positivity. The gDNA from GFP-positive cells was extracted using QIAamp DNA Mini kit (Qiagen) according to manufacturer’s protocol. Viral RNA was extracted from concentrated virus using the NucleoSpin kit (Macherey-Nagel) according to manufacturer’s protocol and reverse- transcribed using SuperScript IV (Thermo Fisher). All cell gDNA and 1 pL of viral cDNA was used as input for PCR reactions and DNA was sequenced by Illumina High-throughput sequencing using methods known in the art.

Example 11, Barcoded Lentiviral Screening protocol

[001215] HEK clone 17 cells were seeded in 96-well plates at a density of 30k cells/well.

After 20-24 hours cells were transfected with the following plasmid mixture: 20 ng Env., 60 ng targeting ligand, 40 ng psPAX2 lentiviral packaging plasmid, and 36 ng lentiviral genome encoding both a NNNNNNNNNNNNNNNNNNNN barcode and the CMV-EGFP-P2A- PuroR gene. Plasmids were prepared using PlasmidPlus Midi and Mini kits (Qiagen).

Plasmids were mixed with 0.5 pL FuGENE 6 (Promega) to a final volume of 10 uL, incubated 10 min, and added to each well.

[001216] 48 hours post-transfection, virus-containing supernatant was harvested and concentrated 1000-3000x by ultracentrifugation with a 20% sucrose cushion. Target cells were then transduced at a dose of 2-10uL of virus into 100k cells. 5 days post-transduction, target cells were stained with relevant antibodies and sorted for GFP-positivity. The gDNA from GFP-positive cells was extracted using QIAamp DNA Mini kit (Qiagen) according to manufacturer’s protocol. Viral RNA was extracted from concentrated virus using the NucleoSpin kit (Macherey-Nagel) according to manufacturer’s protocol and reverse- transcribed using SuperScript IV (Thermo FisherScientific). All cell gDNA and 1 mL of viral cDNA was used as input for Genomic loci were amplified in PCR1 using NEBNext polymerase (New England Biolabs)). PCR1 primers for the BCL11A genomic locus are:

[001217] PCR1 was performed as follows: 98°C for 3 min; 15-30 cycles of 98°C for 15 s, 61°C for 20 s, and 72°C for 30 s; 72°C for 2 min. PCR1 was performed on qPCR to avoid overamplification. PCR1 products were confirmed on a 1.5% agarose gel. luL PCR1 was used as input for PCR2 to install the Illumina barcodes. PCR2 was conducted for 9 cycles using NEBNext polymerase (New England Biolabs). Following PCR2, samples were pooled and gel purified in a 1% agarose gel using a Qiaquick Gel Extraction Kit (Qiagen). Library concentration was determined by Qubit High-Sensitivity Assay Kit (Thermo Fisher Scientific). Samples were sequenced on an Illumina Miseq instrument (paired-end read, read 1: 250-300 cycles, read 2: 0 cycles) using an illumine Miseq 300 v2 Kit (Illumina).

Example 12, Targeted ligands for CD34+ cells identified from an exemplary lentiviral screen comprising VSVG and/or VSVG mutant fusogens..

[001218] The results from the screen are shown graphically in FIGs. 14B and 14D.

[001219] The corresponding tabular data for all reads, normalized to cDNA representation, is shown below for the targeting ligands (note that NA in Targeting ligand 2 represents a lentivirus with a single targeting ligand). Viruses low in cDNA reads (maximum barcode cDNA reads <100) were filtered by setting their gDNA read counts to zero.

[001220] The corresponding tabular data for mean and median reads, normalized to cDNA representation, for the positive control (VSVG) and negative control (VSVGmut), respectively is shown below:

Example 13. Targeted ligands for CD34+ cells identified from lentiviral screens comprising Cocal mutant fusogens.

[001221] The results from the screen are shown graphically in FIGs. 18A and 18B.

[001222] The corresponding tabular data for all reads, normalized to cDNA representation, is shown below for the targeting ligands (note that NA in Targeting ligand 2 represents a lentivirus with a single targeting ligand):

[001223] The corresponding tabular data for mean and median reads, normalized to cDNA representation, for the positive control (Cocal) and negative control (Cocalmut), respectively is shown below:

Example 14, Targeted ligands for CD34+ cells identified from a second exemplary lentiviral screen comprising VSVG and/or VSVG mutant fusogens.

[001224] The results from the screen are shown graphically in FIGs. 19A and 19B.

[001225] The tabular data for all reads, normalized to cDNA representation, is shown below for the targeting ligands (note that NA in Targeting ligand 2 represents a lentivirus with a single targeting ligand):

REFERENCES

[001226] Li, C. et al. Safe and efficient in vivo hematopoietic stem cell transduction in nonhuman primates using HDAd5/35++ vectors. Mol Ther - Methods Clin Dev 24, 127-141 (2022).

[001227] Gutierrez- Guerrero, A., Cosset, F.-L. & Verhoeyen, E. Lentiviral Vector Pseudotypes: Precious Tools to Improve Gene Modification of Hematopoietic Cells for Research and Gene Therapy. Viruses 12, 1016 (2020).

[001228] Girard-Gagnepain, A. et al. Baboon envelope pseudotyped LVs outperform VSVG-LVs for gene transfer into early-cytokine-stimulated and resting HSCs. Blood 124, 1221-1231 (2014).

[001229] Cheng, H., Zheng, Z. & Cheng, T. New paradigms on hematopoietic stem cell differentiation. Protein Cell 11, 34-44 (2020).

[001230] Araki, M. et al. Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms. Blood 127, 1307-1316 (2016).

[001231] Verhoeyen, E. et al. Novel lentiviral vectors displaying “early-acting cytokines” selectively promote survival and transduction of NOD/SCID repopulating human hematopoietic stem cells. Blood 106, 3386-3395 (2005).

[001232] Fielding, A. K., Maurice, M., Morling, F. J., Cosset, F. L. & Russell, S. J. Inverse targeting of retroviral vectors: selective gene transfer in a mixed population of hematopoietic and nonhematopoietic cells. Blood 91, 1802-9 (1998).

[001233] Cosset, F. L. et al. Retroviral retargeting by envelopes expressing an N-terminal binding domain. J Virol 69, 6314-6322 (1995). [001234] Ho, C. C. M. et al. Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling. Cell 168, 1041-1052. el8 (2017).

[001235] Takematsu, E. et al. Transmembrane stem cell factor protein therapeutics enhance revascularization in ischemia without mast cell activation. Nat Commun 13, 2497 (2022).

[001236] Fujiwara, K. et al. Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold. Cells 9, 1182 (2020).

[001237] Schafer, D. et al. A Novel Siglec-4 Derived Spacer Improves the Functionality of CAR T Cells Against Membrane-Proximal Epitopes. Front Immunol 11, 1704 (2020).

[001238] Yu, B. et al. Engineered cell entry links receptor biology with single-cell genomics. Cell 185, 4904-4920.e22 (2022).

[001239] Frietze, K. M., Peabody, D. S. & Chackerian, B. Engineering virus-like particles as vaccine platforms. Curr Opin Virol 18, 44-49 (2016).

[001240] Sockolosky, J. T., Kivimae, S. & Szoka, F. C. Fusion of a Short Peptide that Binds Immunoglobulin G to a Recombinant Protein Substantially Increases Its Plasma Half- Life in Mice. Pios One 9, el02566 (2014).

[001241] Sugita, T. et al. Screening of peptide ligands that bind to the Fc region of IgG using peptide array and its application to affinity purification of antibody. Biochem Eng J 79, 33-40 (2013).

[001242] Lee, J. H., Engler, J. A., Coll, J. F. & Moore, B. A. Receptor mediated uptake of peptides that bind the human transferrin receptor. European Journal of Biochemistry (2001).

[001243] Guerrerio, A. L. & Berg, J. M. Design of Single-Stranded Nucleic Acid Binding Peptides Based on Nucleocapsid CCHC-Box Zinc-Binding Domains. J Am Chem Soc 132, 9638-9643 (2010).

[001244] Li, N., Larson, T., Nguyen, H. H., Sokolov, K. V. & Ellington, A. D. Directed evolution of gold nanoparticle delivery to cells. Chem Commun 46, 392-394 (2009).

[001245] Czechowicz, A., Palchaudhuri, R., Scheck, A. et al. Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation. Nat Commun 10, 617 (2019). https://doi.org/10.1038/s41467-018-08201-x

[001246] Costa, M.J., Kudaravalli, J., Ma, JT. et al. Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates. Sci Rep 9, 2443 (2019). https://doi.org/10.1038/s41598-019-38745-x [001247] Dobson, C.S., Reich, A.N., Gaglione, S. et al. Antigen identification and high- throughput interaction mapping by reprogramming viral entry. Nat Methods 19, 449-460 (2022). https://doi.org/10.1038/s41592-022-01436-z

[001248] Pisani, A.; Donno, R.; Gennari, A.; Cibecchini, G.; Catalano, F.; Marotta, R.; Pompa, P.P.; Tirelli, N.; Bardi, G. CXCL12-PLGA/Pluronic Nanoparticle Internalization Abrogates CXCR4-Mediated Cell Migration. Nanomaterials 2020, 10, 2304. http s ://doi . org/ 10.3390/nano 10112304

[001249] Guo, F., Wang, Y., Liu, J. et al. CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks. Oncogene 35, 816-826 (2016). https://doi.org/10.1038/onc.2015.139

[001250] Humbert, O. et al. Development of Third-generation Cocal Envelope Producer Cell Lines for Robust Lentiviral Gene Transfer into Hematopoietic Stem Cells and T-cells. Mol. Ther. 24, 1237-1246 (2016).

[001251] Thomas, J., Burkmueller, K., Kanestrom, G., Radtke, S. & Kiem, H.-P. CD90- Targeted Cocal-Pseudotyped Lentivirus As a Robust Platform for Human HSC Gene Therapy. Blood 142, 2254 (2023).

[001252] Strebinger, D. et al. Cell type-specific delivery by modular envelope design. Nat. Commun. 14, 5141 (2023).

[001253] Banskota, Raguram et al., Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins. Cell 185, 250-265 (2022).

EQUIVALENTS AND SCOPE

[001254] In the claims articles such as “a,” “an,” and “the” may mean one or more than one unless indicated to the contrary or otherwise evident from the context. Claims or descriptions that include “or” between one or more members of a group are considered satisfied if one, more than one, or all of the group members are present in, employed in, or otherwise relevant to a given product or process unless indicated to the contrary or otherwise evident from the context. The invention includes embodiments in which exactly one member of the group is present in, employed in, or otherwise relevant to a given product or process. The invention includes embodiments in which more than one, or all of the group members are present in, employed in, or otherwise relevant to a given product or process.

[001255] Furthermore, the invention encompasses all variations, combinations, and permutations in which one or more limitations, elements, clauses, and descriptive terms from one or more of the listed claims is introduced into another claim. For example, any claim that is dependent on another claim may be modified to include one or more limitations found in any other claim that is dependent on the same base claim. Where elements are presented as lists, e.g., in Markush group format, each subgroup of the elements is also disclosed, and any element(s) may be removed from the group. It should it be understood that, in general, where the invention, or aspects of the invention, is/are referred to as comprising particular elements and/or features, certain embodiments of the invention or aspects of the invention consist, or consist essentially of, such elements and/or features. For purposes of simplicity, those embodiments have not been specifically set forth in haec verba herein. It is also noted that the terms “comprising” and “containing” are intended to be open and permits the inclusion of additional elements or steps. Where ranges are given, endpoints are included. Furthermore, unless otherwise indicated or otherwise evident from the context and understanding of one of ordinary skill in the art, values that are expressed as ranges can assume any specific value or sub-range within the stated ranges in different embodiments of the invention, to the tenth of the unit of the lower limit of the range, unless the context clearly dictates otherwise.

[001256] This application refers to various issued patents, published patent applications, journal articles, and other publications, all of which are incorporated herein by reference. If there is a conflict between any of the incorporated references and the instant specification, the specification shall control. In addition, any particular embodiment of the present invention that falls within the prior art may be explicitly excluded from any one or more of the claims. Because such embodiments are deemed to be known to one of ordinary skill in the art, they may be excluded even if the exclusion is not set forth explicitly herein. Any particular embodiment of the invention may be excluded from any claim, for any reason, whether or not related to the existence of prior art.

[001257] Those skilled in the art will recognize or be able to ascertain using no more than routine experimentation many equivalents to the specific embodiments described herein. The scope of the present embodiments described herein is not intended to be limited to the above Description, but rather is as set forth in the appended claims. Those of ordinary skill in the art will appreciate that various changes and modifications to this description may be made without departing from the spirit or scope of the present invention, as defined in the following claims.

Claims

CLAIMS What is claimed is:

1. A virus-like particle comprising: a fusion protein, wherein the fusion protein comprises:

(i) a transmembrane domain; and

(ii) a targeting domain, wherein the targeting domain is not a viral envelope glycoprotein, an antibody, or an antibody fragment.

2. The virus-like particle of claim 1, wherein the transmembrane domain is selected from the group consisting of CD28, CD43, CD49d, CD62L, CD 162, HLA-A2, HLA-DRA, ICAM1, LFA-1, mCD3z, mCD4, mCD8a, hCD8a, hCD8a, and VSVG-TM.

3. The virus-like particle of claim 1, wherein the transmembrane domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5%, or 100% identical to the amino acid sequence of SEQ ID NO: 371 (LFA-1).

4. The virus-like particle of claim 1 wherein the transmembrane domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5%, or 100% identical to the amino acid sequence of SEQ ID NO: 369 (HLA-DRA).

5. The virus-like particle of claim 1, wherein the transmembrane domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 368 (HLA-A2).

6. The virus-like particle of claim 1, wherein the transmembrane domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 366 (CD62L).

7. The virus-like particle of claim 1, wherein the transmembrane domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 364 (CD43).

8. The virus-like particle of claim 1, wherein the transmembrane domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 376 (VSVGTM).

9. The virus-like particle of claim 1, wherein the transmembrane domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 377 (VSVGTM ^ASP).

10. The virus-like particle of claim 1, wherein the transmembrane domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of any one of SEQ ID NOs.: 363-376 or 493.

11. The virus-like particle of claim 1, wherein the targeting domain is selected from the group consisting of CALR-del52, CALR-ins5, CXCL12, AdF35, mSCF soluble, mSCF soluble (V49L/F63L), SCF, SCF mutant (V49L/F63L/K91E/I98R), SCF mutant (V49L/F63L/K91E), SCF mutant (V49L/F63L), SCF soluble, SCF soluble mutant (V49L/F63L/K91E/I98R), SCF soluble mutant (V49E/F63E/K91E), SCF soluble mutant (V49E/F63E), TPO-157, TPO-163, TPO-171, TPO, CXCE11, CXCE4, CXCE14, 53E11 a- hCD8 DARPin, CD8 51.1-Xencor-H1E1 scFv, 53F6 a-hCD8 DARPin, 53F6 a-hCD8 DARPin, 63A4 a-hCD8 DARPin, Acapatamab CD, Acapatamab Vh-Vk, Acapatamab Vh-Vl, CD3 DARPin-C7vl4, CD3 DARPin-C7vl l8, CD3 DARPin-C7vl l9, CD3 DARPin-C7vl22, CD3 DARPin-C7vl27, scFv-CD3-l, scFv-CD3-2, scFv-CD3-3, scFv-CD3-4, scFv-CD4-l, scFv-CD4-2, Sana CD19 scFv FMC63 G4S linker, Sana CD22 scFv m971-L7, CD28 scFv, hCD117 scFv Ab54 CA3079215A1, hCD117 scFv Ab55 CA3079215A1, hCD117 scFv Ab56 CA3079215A1, hCD117 scFv Ab57 CA3079215A1, hCD117 scFv Ab61 CA3079215A1, hCD117 scFv Ab66 CA3079215A1, hCD117 scFv Ab67 CA3079215A1, hCD117 scFv Ab68 CA3079215A1, hCD117 scFv Ab69 CA3079215A1, USPTO 6,054,297 genentech hCD117 scFv, Sana CD8 scFv form 1, Sana CD8 scFv form 2, Sana CD8 scFv form 3, Sana CD8 scFv form 4, Sana CD8 scFv form 5, Sana CD8 scFv form 6, Sana CD8 scFv form 7, Sana CD8 scFv form 8, Sana CD8 scFv form 9, Sana CD8 scFv form 10, Sana CD8 VHH form 1, Sana CD8 VHH form 2, and Sana CD8 VHH form 3.

12. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5%, or 100% identical to the amino acid sequence of SEQ ID NO: 359 (TPO).

13. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 358 (TPO- 171).

14. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 357 (TPO- 163).

15. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 356 (TPO- 157).

16. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 347 (mSCF soluble).

17. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 348 (SCF).

18. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 349 (SCF mutant (V49L/F63L/K91E/I98R).

19. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 350 (SCF mutant (V49L/F63L/K91E)).

20. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 351 (SCF mutant (V49L/F63L).

21. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 352 (SCF soluble).

22. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 353 (SCF soluble mutant (V49L/F63L/K91E/I98R).

23. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 354 (SCF soluble mutant (V49L/F63L/K91E).

24. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 355 (SCF soluble mutant (V49L/F63L).

25. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 346 (AdF35).

26. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 345 (CXCL12).

27. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 360 (CXCL11).

28. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 361 (CXCL4).

29. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 362 (CXCL14).

30. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 344 (CALR-ins5).

31. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 343 (CALR-del52).

32. The virus-like particle of claim 1, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of any one of SEQ ID NOs: 343-362, 387, 900-944, 504-522, or 527-533.

33. The virus-like particle of claim 1-32, wherein the fusion protein comprises the structure:

[optional signaling protein] -[TPO]- [optional linker] -[VS VGTM].

34. The virus-like particle of any one of claims 1-32, wherein the fusion protein comprises the structure:

[optional signaling protein]- [SCFK9iE^mono]- [optional linker] -[ VS VGmut].

35. The virus-like particle of any one of claims 1-32, wherein the fusion protein comprises the structure:

[optional signaling protein]- [ADF35]- [optional linker] -[VS VGTM].

36. The virus-like particle of any one of claims 1-32, wherein the fusion protein comprises the structure:

[optional signaling protein]- [SCF]- [optional linker] -[ VS VG].

37. The virus-like particle of any one of claim 1-32, wherein the fusion protein comprises the structure:

[optional signaling protein]- [SCF(V49L/F63L)]-[optional linker]-[VSVG TM].

38. The virus like particle of any one of claims 1-32, wherein the fusion protein comprises the structure:

[optional signaling protein]- [SCF V49L/F63L/K9 IE] -[optional linker]- [VS VG_mut^{A SP}].

39. The virus like particle of any one of claim 1-32, wherein the fusion protein comprises the structure:

[VSVG Signal Peptide]-[SCF soluble]-[SGGSGGSGGS linker]-[VSVG TM],

40. The virus like particle of any one of claim 1-32, wherein the fusion protein comprises the structure:

[optional signaling protein] -[CXCL 12] -[optional linker] -[ VS VGmut del SP].

41. The virus like particle of any one of claim 1-32, wherein the fusion protein comprises the structure:

[VSVG Signal Peptide]-[SCF soluble (V49L/F63L/K91E/I98R)]-[SGGSGGSGGS linker]-[VSVG TM],

42. The virus like particle of any one of claim 1-32, wherein the fusion protein comprises the structure:

[optional signaling protein]- [SCF soluble] -[optional linker] -[VS VGmut del SP].

43. The virus-like particle of any one of claims 1-42, further comprising a first linker that connects (i) and (ii), wherein the first linker is selected from the group consisting of SEQ ID NO:s. 309-342.

44. The virus-like particle of any one of claims 1-43, further comprising a second fusion protein comprising a transmembrane domain, a targeting domain, and optionally, a stalk domain, wherein the targeting domain is not a viral envelope glycoprotein, an antibody, or an antibody fragment.

45. The virus-like particle of claim 44, wherein a targeting domain of the second fusion protein is different than the targeting domain of the first fusion protein.

46. A virus-like particle comprising a fusion protein, wherein the fusion protein comprises:

(i) a transmembrane domain;

(ii) a stalk domain; and

(iii) a targeting domain, wherein the targeting domain is not a viral envelope glycoprotein, an antibody, or an antibody fragment.

47. The virus-like particle of claim 46, wherein the transmembrane domain is selected from the group consisting of CD28, CD43, CD49d, CD62L, CD 162, HLA-A2, HLA-DRA, ICAM1, LFA-1, mCD3z, mCD4, mCD8a, hCD8a, hCD8a, and VSVG-TM.

48. The virus-like particle of claim 46, wherein the transmembrane domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to any one of the amino acid sequences of SEQ ID NO:s: 363-376 or 493.

49. The virus-like particle of claim 46, wherein the targeting domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to any one of the amino acid sequences of SEQ ID NO:s: 343- 362, 387, 900-944, 504-522, or 527-533.

50. The virus-like particle of claim 46, wherein the targeting domain is selected from the group consisting of CALR-del52, CALR-ins5, CXCL12, AdF35, mSCF soluble, SCF, SCF mutant (V49L/F63L/K91E/I98R), SCF mutant (V49E/F63E/K91E), SCF mutant (V49E/F63E), SCF soluble, SCF soluble mutant (V49E/F63E/K91E/I98R), SCF soluble mutant (V49E/F63E/K91E), SCF soluble mutant (V49E/F63E), TPO-157, TPO-163, TPO- 171, TPO, CXCE11, CXCE4, CXCE14, 53E11 a-hCD8 DARPin, CD8 51.1-Xencor-H1E1 scFv, 53F6 a-hCD8 DARPin, 53F6 a-hCD8 DARPin, 63A4 a-hCD8 DARPin, Acapatamab CD, Acapatamab Vh-Vk, Acapatamab Vh-Vl, CD3 DARPin-C7vl4, CD3 DARPin-C7vl l8, CD3 DARPin-C7vl l9, CD3 DARPin-C7vl22, CD3 DARPin-C7vl27, scFv-CD3-l, scFv- CD3-2, scFv-CD3-3, scFv-CD3-4, scFv-CD4-l, scFv-CD4-2, Sana CD19 scFv FMC63 G4S linker, Sana CD22 scFv m971-E7, CD28 scFv, hCD117 scFv Ab54 CA3079215A1, hCD117 scFv Ab55 CA3079215A1, hCD117 scFv Ab56 CA3079215A1, hCD117 scFv Ab57 CA3079215A1, hCD117 scFv Ab61 CA3079215A1, hCD117 scFv Ab66 CA3079215A1, hCD117 scFv Ab67 CA3079215A1, hCD117 scFv Ab68 CA3079215A1, hCD117 scFv Ab69 CA3079215A1, USPTO 6,054,297 genentech hCD117 scFv, Sana CD8 scFv form 1, Sana CD8 scFv form 2, Sana CD8 scFv form 3, Sana CD8 scFv form 4, Sana CD8 scFv form 5, Sana CD8 scFv form 6, Sana CD8 scFv form 7, Sana CD8 scFv form 8, Sana CD8 scFv form 9, Sana CD8 scFv form 10, Sana CD8 VHH form 1, Sana CD8 VHH form 2, and Sana CD8 VHH form 3.

51. The virus-like particle of claim 46 wherein the stalk domain is selected from the group consisting of hCD8a-l, hCD8a-2, h!gG4-CH3, mCD3z, mCD4, mCD8a-l, mCD8a-2, hCD8a’, mCD28, hCD8, Siglec-4:12, IgGl-CH3, IgG4-CH2CH3, IgGl-CH2CH3, IgGl-1, IgGl-2, IgG2, IgG3, and IgG4.

52. The virus-like particle of claim 46, wherein stalk domain is selected from the group consisting of hCD8a-l, hCD8a-2, h!gG4-CH3, mCD3z, mCD4, mCD8a-l, mCD8a-2, hCD8a’, mCD28, hCD8, Siglec-4:12, IgGl-CH3, IgG4-CH2CH3, IgGl-CH2CH3, IgGl-1, IgGl-2, IgG2, IgG3, and IgG4.

53. The virus-like particle of claim 46, wherein the stalk domain is selected from the group consisting of mmIgG2_l, mmIgG2_2, and mmIgG2_3.

54. The virus-like particle of claim 46, wherein the stalk domain is selected from the group consisting of IgG3_l, IgG3_2, IgG3_3, IgG3_4, IgG3_5, IgG3_6, IgGl_3, IgGl_4, IgG3_7, IgG2_l, and IgGl_3.

55. The virus-like particle of claim 46, wherein the stalk domain is selected from the group consisting of IgAl_l, IgAl_2, IgAl_3, IgAl_4, IgA2_l, IgA2_2, IgA2_3, and IgA2_4.

56. The virus-like particle of claim 46, wherein the stalk domain is selected from the group consisting of IgD_l, IgD_2, IgD_3, IgD_4, IgE, IgM_l, IgM_2, IgM_3, and IgGl_4.

57. The virus-like particle of claim 46, wherein the stalk domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to any one of the amino acid sequences of SEQ ID NOs.: 29-47. or SEQ ID NO: 404.

58. The virus-like particle of claim 46, wherein the stalk domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to any one of the amino acid sequences of SEQ ID NO:s: 48-57.

59. The virus-like particle of claim 46, wherein the stalk domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to any one of the amino acid sequences of SEQ ID NO:s: 58-60.

60. The virus-like particle of claim 46, wherein the stalk domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to any one of the amino acid sequences of SEQ ID NO:s: 61-71.

61. The virus-like particle of claim 46, wherein the stalk domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to any one of the amino acid sequences of SEQ ID NO:s: 72-79.

62. The virus-like particle of claim 46, wherein the stalk domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to any one of the amino acid sequences of SEQ ID NO:s: 80-88.

63. The virus-like particle of claim 46, wherein the stalk domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to any one of the amino acid sequences of SEQ ID NO:s: 502-503, 894, or 896-899.

64. The virus-like particle of claim 46, wherein the stalk domain comprises IgG4.

65. The virus-like particle of claim 46, wherein the stalk domain comprises CD8a.

66. The virus-like particle of claim 46-65, wherein the fusion protein comprises a structure selected from the group consisting of [SCF]- [optional linker] -[IgG4]- [optional linker] -[CD62], [SCF] -[optional linker] -[CD8]- [optional linker] -[CD43], [SCF] -[optional linker] -[CD8]- [optional linker] -[CD62], [SCF] -[optional linker] -[CD8]- [optional linker]- [HLA-A2], [SCF] -[optional linker] -[CD8]- [optional linker] -[HLA-DRA], and [SCF]- [optional linker] -[CD8]- [optional linker]-[LFA-l].

67. The virus like particle of any one of claims 46-65, wherein the fusion protein comprises the structure:

[CD8 Signal Peptide]- [CD 117 scFv 67]-[CD8a trunc stalk]-[ICAMl TM],

68. The virus like particle of any one of claims 46-65, wherein the fusion protein comprises the structure:

[CD8 Signal Peptide]-[SCF]-[CD8a trunc stalk]-[CD62 TM],

69. The virus like particle of any one of claims 46-65, wherein the fusion protein comprises the structure:

[B2M Signal Peptide]-[SCF]-[CD8a trunc stalk]-[CD49 TM],

70. The virus like particle of any one of claims 46-65, wherein the fusion protein comprises the structure:

[CD8 Signal Peptide]-[TPO]-[CD8a trunc stalk]-[ICAMl TM],

71. The virus like particle of any one of claims 46-65, wherein the fusion protein comprises the structure:

[CD8 Signal Peptide] -[AdF35]-[CD8a trunc stalk]-[CD62 TM],

72. The virus like particle of any one of claims 46-65, wherein the fusion protein comprises the structure:

[B2M Signal Peptide]-[SCF]-[CD8 trunc stalk]-[LFAl TM],

73. The virus like particle of any one of claims 46-65, wherein the fusion protein comprises the structure:

[CD8 Signal Peptide] -[CXCL 12] -[CD 8 a trunc stalk]-[ICAMl TM],

74. The virus like particle of any one of claims 46-65, wherein the fusion protein comprises the structure:

[CD8 Signal Peptide] -[CXCL 12] -[CD 8 a trunc stalk]-[HLA A2 TM],

75. The virus like particle of any one of claims 46-65, wherein the fusion protein comprises the structure:

[CD90 scFv]-[CD8a trunc stalk]-[ICAMl TM],

76. The virus like particle of any one of claims 46-65, wherein the fusion protein comprises the structure:

[CD8 Signal Peptide] -[CXCL 12] -[CD 8 a trunc stalk]-[CD49 TM],

77. The virus like particle of any one of claims 46-65, wherein the fusion protein comprises the structure:

[CD8 Signal Peptide]- [CXCL 12] -[ CD8a trunc stalk]-[LFAl TM],

78. The virus like particle of any one of claims 46-65, wherein the fusion protein comprises the structure:

[CD90 scFv]-[CD8a trunc stalk]-[LFAl TM],

79. The virus-like particle of claim 46-78, wherein a first linker connects (i) and (ii) and is selected from the group consisting of SEQ ID NOs.: 309-342.

80. The virus-like particle of claim 46-79, wherein a second linker connects (ii) and (iii) and is selected from the group consisting of SEQ ID NOs:. 309-342.

81. The virus-like particle of any one of claims 46-80, further comprising a second fusion protein comprising a transmembrane domain, a targeting domain, and optionally, a stalk domain, wherein the targeting domain is not a viral envelope glycoprotein, an antibody, or an antibody fragment.

82. The virus-like particle of claim 81, wherein a targeting domain of the second fusion protein is different than the targeting domain of the first fusion protein.

83. A virus-like particle comprising:

(a) a fusion protein, wherein the fusion protein comprises:

(i) a transmembrane domain; and

(ii) a targeting domain; and

(b) an antibody domain, wherein the targeting domain of the fusion protein binds to the antibody domain to form a virus-like particle-antibody complex, and wherein the targeting domain is not an envelope glycoprotein, an antibody, or an antibody fragment.

84. A virus-like particle comprising:

(a) a fusion protein, wherein the fusion protein comprises:

(i) a transmembrane domain;

(ii) a stalk domain; and

(iii) a targeting domain; and

(b) an antibody domain, wherein the targeting domain binds to the antibody domain to form a virus-like particle-antibody complex, and wherein the targeting domain is not an envelope glycoprotein, an antibody, or an antibody fragment.

85. The virus-like particle of claim 84, wherein the stalk domain is IgG4 or CD8a.

86. The virus-like particle of claims 83 or 84, wherein the transmembrane domain is selected from the group consisting of CD28, CD43, CD49d, CD62L, CD 162, HLA-A2, HLA-DRA, ICAM1, LFA-1, mCD3z, mCD4, mCD8a, hCD8a, and VSVG-TM.

87. The virus-like particle of claim 83 or 84, wherein the transmembrane domain comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to any one of the amino acid sequences of SEQ ID NO:s: 363-376 or 493.

88. The virus-like particle of claims of claim 83 or 84, wherein the targeting domain binds to the antibody domain to form the virus-like particle complex.

89. The virus-like particle claims of claim 83 or 84, wherein the targeting domain comprises an IgG-binding peptide.

90. The virus-like particle of claim 89, wherein the IgG-binding peptide has an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to any one of the amino acid sequences of SEQ ID NO:s. 200- 307.

91. The virus-like particle of claim 89 or 90, wherein the IgG-binding peptide binds to one or more IgG protein domains of an IgG antibody.

92. The virus-like particle of 91, wherein the IgG antibody further binds to an antigen on a target cell.

93. The virus-like particle of claim 92, wherein the antigen on the target cell comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 384 (Seal).

94. The virus-like particle of claim 92, wherein the antigen on the target cell comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 381 or 396CD117).

95. The virus-like particle of claim 92, wherein the antigen on the target cell comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO:385 or 397 (CD150).

96. The virus-like particle of claim 92, wherein the antigen on the target cell comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO:382 or 398 (CXCR4).

97. The virus-like particle of claim 92, wherein the antigen on the target cell comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO:383 or 401 (CD46).

98. The virus-like particle of claims 83-97, wherein the fusion protein comprises the structure selected from the group consisting of: [targeting domain] -[optional linker] -[stalk domain] -[optional linker] -[transmembrane domain] or [Z peptide] -[optional linker] -[IgG4 Fc CH3]- [optional linker]-[CD28].

99. A virus-like particle comprising at least one conjugation domain.

100. The virus-like particle of claim 99, further comprising a targeting domain linked to a transmembrane domain or a viral envelope glycoprotein domain via the conjugation domain.

101. The virus-like particle of claim 100, wherein the targeting domain is selected from the group consisting of antibodies, nucleic acids, aptamers, fluorophores, glycoproteins, proteins, peptides, and small molecules.

102. The virus-like particle of claim 100 or 101, wherein the targeting domain comprises a click chemistry handle.

103. The virus-like particle of claim 102, wherein the click chemistry handle is selected from the group consisting of azides, dibenzoazacyclooctyne (DIB AC or DBCO), biarylazacyclooctynone (BARAC), dibenzocyclooctyne (DIBO), difluorinated cyclooctyne (DIFO), bicyclononyne (BCN), dimethoxyazacyclooctyne (DIMAC), monofluorinated cyclooctyne (MOFO), cyclooctyne (OCT), and/or aryl-less cyclooctyne (ALO).

104. The virus-like particle of any one of claims 100-103, wherein the linkage between the targeting domain and the transmembrane domain or envelope glycoprotein domain comprises a 1,2,3-triazole ring.

105. The virus-like particle of any one of claims 99-104, wherein the conjugation domain is selected from the group consisting of one or more N-azidoacetylglucosamine (GlcNAz) or an acetylated variant thereof, one or more N-azidoacetylmannosamine (ManNAz) or an acetylated variant thereof, one or more N-azidoacetylgalactosamine (GalNAz) or an acetylated variant thereof, one or more 6-azidofucose (6AzFuc) or an acetylated variant thereof, one or more N-azidoacetylneuraminic acid (SiaNAz) or an acetylated variant thereof, one or more N-(4-pentynoyl mannosamine) (ManNAl) or an acetylated variant thereof, one or more N-(4-pentynoyl galactosamine) (GalNAl) or an acetylated variant thereof, one or more N-(4-pentynoyl glucosamine) (GlcNAl) or an acetylated variant thereof, one or more N- (4-pentynoyl neuraminic acid) (SiaNAl) or an acetylated variant thereof and one or more 6- alkynyl fucose or an acetylated variant thereof.

106. The virus-like particle of claim 1, 38, 83-84 or 99, further comprising a viral envelope glycoprotein and/or a mutated version thereof.

107. The virus-like particle of claim 106, wherein the viral envelope glycoprotein and/or mutated version thereof is an adenoviral envelope glycoprotein, an adeno-associated viral envelope glycoprotein, a retroviral envelope glycoprotein, or a lentiviral envelope glycoprotein.

108. The virus-like particle of claim 106, wherein the viral envelope glycoprotein and/or a mutated version thereof is a retroviral envelope glycoprotein.

109. The virus-like particle of claim 106, wherein the viral envelope glycoprotein and/or a mutated version thereof is a vesicular stomatitis virus G protein (VSVG), a baboon retroviral envelope glycoprotein (BaEVRless), a FuG-B2 envelope glycoprotein, an HIV-1 viral envelope glycoprotein, a Cocal virus envelope glycoprotein, or an ecotropic murine leukemia virus (MLV) envelope glycoprotein.

110. The virus-like particle of claim 106-109, wherein the mutated viral envelope glycoprotein retains its fusogenic activity.

111. The virus-like particle of claim 106- 110, wherein the mutated viral envelope glycoprotein does not bind to its native ligand.

112. The virus-like particle of claim 1, 38, 83-84 or 99, further comprising a group- specific antigen (gag) protease (pro) polyprotein.

113. The virus-like particle of claim 112, wherein the gag-pro polyprotein comprises an MMLV gag-pro polyprotein or an FMLV gag-pro polyprotein.

114. The virus-like particle of claim 1, 38, 83-84 or 99, further comprising a second fusion protein comprising a group specific antigen (gag) nucleocapsid protein, cargo protein, a cleavable linker, and a nuclear export sequence.

115. The virus like particle of claim 114, wherein the second fusion protein further comprises a domain selected from the group consisting of polymerases, recombinases, integrases, adenine oxides, guanine oxidases, guanine methyltransferases, transglycosylases, adenosine methyltransferases, glycosylases, and thymine alkyltransferases.

116. The virus-like particle of claim 114, wherein the gag nucleocapsid protein comprises an MMLV gag nucleocapsid protein or an FMLV gag nucleocapsid protein.

117. A cell comprising the virus-like particle of any one of claims 1-116.

118. One or more polynucleotides comprising (i) a first nucleic acid sequence encoding a first fusion protein, wherein the first fusion protein comprises:

(1) a transmembrane domain;

(2) optionally, a stalk domain, and

(3) a targeting domain, wherein the targeting domain is not a viral envelope glycoprotein, an antibody, or an antibody fragment.

119. The one or more polynucleotides of claim 118, further comprising a second nucleic acid sequence encoding a viral envelope glycoprotein.

120. The one or more polynucleotides of claim 119, wherein the viral envelope glycoprotein is an adenoviral envelope glycoprotein, an adeno-associated viral envelope glycoprotein, a retroviral envelope glycoprotein, or a lentiviral envelope glycoprotein.

121. The one or more polynucleotides of claim 119, wherein the viral envelope glycoprotein is a retroviral envelope glycoprotein.

122. The one or more polynucleotides of claim 119, wherein the viral envelope glycoprotein is a vesicular stomatitis virus G protein (VSVG), a baboon retroviral envelope glycoprotein (BaEVRless), a FuG-B2 envelope glycoprotein, an HIV-1 viral envelope glycoprotein, or an ecotropic murine leukemia virus (MLV) envelope glycoprotein.

123. The one or more polynucleotides of claim 118-122, further comprising a third nucleic acid sequence encoding a mutated viral envelope glycoprotein.

124. The one or more polynucleotides of claim 123, wherein the mutated viral envelope glycoprotein retains its fusogenic activity.

125. The one or more polynucleotides of claim 123 or 124, wherein the mutated viral envelope glycoprotein does not bind to its native ligand.

126. The one or more polynucleotides of any one of claims 123-125, wherein the mutated viral envelope glycoprotein is a mutated version of an adenoviral envelope glycoprotein, an adeno-associated viral envelope glycoprotein, a retroviral envelope glycoprotein, or a lentiviral envelope glycoprotein.

127. The one or more polynucleotides of any one of claims 123-125, wherein the mutated viral envelope glycoprotein is a mutated version of a retroviral envelope glycoprotein.

128. The one or more polynucleotides of any one of claims 123-125, wherein the mutated viral envelope glycoprotein is a mutated version of a vesicular stomatitis virus G protein (VSVG), a baboon retroviral envelope glycoprotein (BaEVRless), a FuG-B2 envelope glycoprotein, an HIV-1 viral envelope glycoprotein, or an ecotropic murine leukemia virus (MLV) envelope glycoprotein.

129. The one or more polynucleotides of claim 118-128, further comprising a fourth nucleic acid sequence encoding a group-specific antigen (gag) protease (pro) polyprotein.

130. The one or more polynucleotides of claim 129, wherein the gag-pro polyprotein comprises an MMLV gag-pro polyprotein or an FMLV gag-pro polyprotein.

131. The one or more polynucleotides of any one of claims 118-130, further comprising a fifth nucleic acid sequence encoding a second fusion protein comprising a group specific antigen (gag) nucleocapsid protein, a cargo protein, a cleavable linker, and a nuclear export sequence.

132. The one or more polynucleotides of claim 131, wherein the cargo protein is a base editor or a prime editor.

133. The one or more polynucleotides of claim 131 or 132, wherein the second fusion protein further comprises a domain selected from the group consisting of polymerases, recombinases, integrases, adenine oxides, guanine oxidases, guanine methyltransferases, transglycosylases, adenosine methyltransferases, glycosylases, and thymine alkyltransferases.

134. The one or more polynucleotides of claim 131-133, wherein the gag nucleocapsid protein comprises an MMLV gag nucleocapsid protein or an FMLV gag nucleocapsid protein.

135. The one or more polynucleotides of any one of claims 118-134, further comprising a sixth nucleic acid sequence encoding a third fusion protein, wherein the third fusion protein comprises:

(1) a transmembrane domain;

(2) optionally, a stalk domain; and

(3) a targeting domain, wherein the targeting domain is not a viral envelope glycoprotein, an antibody, or an antibody fragment;

136. The one or more polynucleotides of any one of claims 118-135, wherein the first nucleic acid sequence encoding the first fusion protein has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 601 (pJAQ222), and wherein the sixth nucleic acid sequence encoding the third fusion protein has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 602 (pJAQ223).

137. The one or more polynucleotides of any one of claims 118-135, wherein the first nucleic acid sequence encoding the first fusion protein has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 597 (pJAQ218), and wherein the sixth nucleic acid sequence encoding the third fusion protein has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 601 (pJAQ222).

138. The one or more polynucleotides of any one of claims 118-135, wherein the first nucleic acid sequence encoding the first fusion protein has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 671 (pJAQ300), and wherein the sixth nucleic acid sequence encoding the third fusion protein has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 713 (pJAQ342).

139. The one or more polynucleotides of any one of claims 118-135, wherein the first nucleic acid sequence encoding the first fusion protein has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 671 (pJAQ300), and wherein the sixth nucleic acid sequence encoding the third fusion protein has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 718 (pJAQ347).

140. One or more vectors comprising the one or more polynucleotides of any one of claims 118-139.

141. The one or more vectors of claim 140, wherein each of the first, second, third, fourth, fifth, and sixth polynucleotides are on separate vectors.

142. The one or more vectors of claim 140, wherein one or more of the first, second, third, fourth, fifth, or sixth polynucleotides are on the same vector.

143. The one or more vectors of any one of claims 140-142, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 109 ([TPO]- [optional linker] -[ VS VGTM]).

144. The one or more vectors of any one of claims 140-142, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 112 [SCFK9 iE^mono]- [optional linker] -[VS VGmut].

145. The one or more vectors of any one of claims 140-142, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 133 [ADF35]- [optional linker] -[ VS VG™].

146. The one or more vectors of any one of claims 140-142, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 92 [SCF]- [optional linker] -[ VS VG],

147. The one or more vectors of any one of claims 140-142, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 123 ([SCF]-[optional linker] -[IgG4]- [CD 62]).

148. The one or more vectors of any one of claims 140-142, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 113 ([SCF]-[optional linker]-[CD8a]-[CD43]).

149. The one or more vectors of any one of claims 140-142, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 115 ([SCF]-[optional linker] -[CD 8 a] -[CD 62]).

150. The one or more vectors of any one of claims 140-142, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 117 ([SCF]-[optional linker] -[CD 8 a] -[HL A- A2]).

151. The one or more vectors of any one of claims 140-142, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 118 ([SCF]-[optional linker]-[CD8a]-[HLA-DRA]).

152. The one or more vectors of any one of claims 140-142, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 120 ([SCF]-[optional linker] -[CD8a]-[LFAl]).

153. The one or more vectors of any one of claims 140-142, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 197 [Z peptide] -[optional linker]-[IgG4 Fc CH3]- [optional linker]-[CD28].

154. The one or more vectors of any one of claims 140-142, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 534-945.

155. A cell comprising the virus-like particles of any one of claims 1-116, the one or more polynucleotides of any one of claims 118-139, or the one or more vectors of any one of claims 140-154.

156. One or more polynucleotides comprising

(i) a first nucleic acid sequence encoding a first fusion protein, wherein the first fusion protein comprises:

(1) a transmembrane domain;

(2) optionally, a stalk domain;

(3) a targeting domain, wherein the targeting domain is not a viral envelope glycoprotein, an antibody, or an antibody fragment;

(ii) a second nucleic acid sequence encoding a viral envelope glycoprotein; and

(iii) a third nucleic acid sequence encoding a group- specific antigen (gag) protease (pro) polyprotein.

157. The one or more polynucleotides of claim 156, further comprising a fourth nucleic acid sequence encoding a second fusion protein comprising group specific antigen (gag) nucleocapsid protein, a cargo protein, a cleavable linker, and a nuclear export sequence.

158. The one or more polynucleotides of claim 157, wherein the cargo protein is a base editor or a prime editor.

159. The one or more polynucleotides of claim 157 or 158, wherein the second fusion protein further comprises a domain selected from the group consisting of polymerases, recombinases, integrases, adenine oxides, guanine oxidases, guanine methyltransferases, transglycosylases, adenosine methyltransferases, glycosylases, and thymine alkyltransferases.

160. The one or more polynucleotides of any one of claims 156-159, wherein the gag nucleocapsid protein comprises an MMLV gag nucleocapsid protein or an FMLV gag nucleocapsid protein.

161. The one or more polynucleotides of any one of claims 156-160, wherein the gag-pro polyprotein comprises an MMLV gag-pro polyprotein or an FMLV gag-pro polyprotein.

162. The one or more polynucleotides of any one of claims 156-161, wherein the viral envelope glycoprotein is an adenoviral envelope glycoprotein, an adeno-associated viral envelope glycoprotein, a retroviral envelope glycoprotein, or a lentiviral envelope glycoprotein.

163. The one or more polynucleotides of any one of claims 156-161, wherein the viral envelope glycoprotein is a retroviral envelope glycoprotein.

164. The one or more polynucleotides of any one of claims 156-161, wherein the viral envelope glycoprotein is a vesicular stomatitis virus G protein (VSVG), a baboon retroviral envelope glycoprotein (BaEVRless), a FuG-B2 envelope glycoprotein, an HIV-1 viral envelope glycoprotein, or an ecotropic murine leukemia virus (MLV) envelope glycoprotein.

165. The one or more polynucleotides of claim 156-164, further comprising a fifth nucleic acid sequence encoding a mutated viral envelope glycoprotein.

166. The one or more polynucleotides of claim 165, wherein the mutated viral envelope glycoprotein retains its fusogenic activity.

167. The one or more polynucleotides of claim 165 or 166, wherein the mutated viral envelope glycoprotein does not bind to its native ligand.

168. The one or more polynucleotides of any one of claims 165-167, wherein the mutated viral envelope glycoprotein is a mutated version of an adenoviral envelope glycoprotein, an adeno-associated viral envelope glycoprotein, a retroviral envelope glycoprotein, or a lentiviral envelope glycoprotein.

169. The one or more polynucleotides of any one of claims 165-167, wherein the mutated viral envelope glycoprotein is a mutated version of a retroviral envelope glycoprotein.

170. The one or more polynucleotides of any one of claims 165-167, wherein the mutated viral envelope glycoprotein is a mutated version of vesicular stomatitis virus G protein (VSVG), a baboon retroviral envelope glycoprotein (BaEVRless), a FuG-B2 envelope glycoprotein, an HIV-1 viral envelope glycoprotein, or an ecotropic murine leukemia virus (MLV) envelope glycoprotein.

171. One or more vectors comprising the one or more polynucleotides of any one of claims 156-170.

172. The one or more vectors of claim 171, wherein each of the first, second, third, fourth, fifth, and sixth polynucleotides are on separate vectors.

173. The one or more vectors of claim 171, wherein one or more of the first, second, third, fourth, fifth and sixth polynucleotides are on the same vector.

174. The one or more vectors of any one of claims 171-173, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 109 ([TPO]- [optional linker] -[VS VGTM]).

175. The one or more vectors of any one of claims 171-173, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 112 [SCFK9 iE^mono]- [optional linker] -[VS VGmut].

176. The one or more vectors of any one of claims 171-173, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 133 [ADF35]- [optional linker] -[VS VGTM].

177. The one or more vectors of any one of claims 171-173, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 92 [SCF]- [optional linker] -[ VS VG],

178. The one or more vectors of any one of claims 171-173, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 123 ([SCF]-[optional linker] -[IgG4]- [CD 62]).

179. The one or more vectors of any one of claims 171-173, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 113 ([SCF]-[optional linker]-[CD8a]-[CD43]).

180. The one or more vectors of any one of claims 171-173, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 115 ([SCF]-[optional linker] -[CD 8 a] -[CD 62]).

181. The one or more vectors of any one of claims 171-173, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 117 ([SCF]-[optional linker] -[CD 8 a] -[HL A- A2]).

182. The one or more vectors of any one of claims 171-173, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 118 ([SCF]-[optional linker]-[CD8a]-[HLA-DRA]).

183. The one or more vectors of any one of claims 171-173, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the nucleic acid sequence of SEQ ID NO: 120 ([SCF]-[optional linker] -[CD8a]-[LFAl]).

184. The one or more vectors of any one of claims 171-173, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 197 [Z peptide] -[optional linker]-[IgG4 Fc CH3]- [optional linker]-[CD28].

185. The one or more vectors of any one of claims 171-173, wherein the one or more polynucleotides has a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 99%, at least 99.5% or 100% identical to the amino acid sequence of SEQ ID NO: 534-945.

186. A cell comprising the virus-like particles of any one of claims 1-116, the one or more polynucleotides of any one of claims 118-139 or 156-170, or the one or more vectors of any one of claims 140-154 or 171-185.

187. A method of delivering a viral-like particle to a target cell comprising preparing the viral-like particles of any one of claims 1-116, the polynucleotides of any one of claims 118- 139 or 156-170, the vectors of any one of claims 140-154 or 171-185, or the cells of claims

117, 155 or 186 and contacting a target cell with one or more of said compositions.

188. The method of claim 187, wherein the cell type is selected from the group consisting of hematopoietic stem and progenitor cells (HPSCs), immune cells, neural cells, or retinal pigment epithelium cells.

189. The method of claim 187 or 188, wherein the targeting domain of the fusion protein targets the eVLP to a particular cell type.

190. The method of any one of claims 187-189, wherein the viral envelope glycoprotein does not target the eVLP to a particular cell type.

191. The method of any one of claim 187-190, wherein the mutated viral envelope glycoprotein retains fusogenic activity.

192. The method of any one of claims 187-191, wherein the mutated viral envelope has a reduced affinity for its native receptor.

193. A method of preparing a virus-like particle comprising transfecting the polynucleotides of any one of claims 118-139 or 156-170, the vectors of any one of claims 140-154 or 171-185 into a producer cell.

194. The method of claim 193, wherein the producer cell is selected from the group consisting of Gesicle 293T cells, HEK 293T, 293G, 293SF, 293FT, 293TN, Eent-X 293T, and inducible custom cell lines with lentivirally integrated VEP genes.

195. A method for editing a nucleic acid molecule in a target cell comprising contacting the target cell with the virus-like particle of any one of claims 118-139 or 156-170, the vectors of any one of claims 140-154 or 171-185, or the cells of claims 117, 155 or 186, thereby installing one or more modification to the nucleic acid molecule at a target site.

196. The method of claim 195, wherein the cell is a mammalian cell.

197. The method of claim 195 or 196, wherein the cell is a human cell.

198. The method of any one of claims 195-197, wherein the cell is in a subject.

199. The method of claim 198, wherein the subject is a human.

200. The method of claim 198, wherein the subject is a non-human.

201. The method of claim 195, wherein the cell is a plant cell.

202. The method of any one of claims 195-201, wherein the one or more modifications to the nucleic acid molecule are associated with reducing, relieving, or preventing the symptoms of a disease or disorder.

203. The method of any one of claims 195-202, wherein the disease or disorder is a CNS disorder, liver disorder, or ocular disorder.

204. A method of treating a disease, comprising, contacting a target cell with the virus-like particle of any one of claims 1-116, the polynucleotides of any one of claims 118-139 or 156- 170, the vectors of any one of claims 140-154 or 171-185, or the cells of claims 117, 155 or 186 wherein contacting the target cells results in reducing, relieving, curing or preventing the symptoms of a disease or disorder.

205. A method of treating a disease by editing a nucleic acid molecule in a target cell, comprising, contacting the target cell with the virus-like particle of any one of claims 1-116, the polynucleotides of any one of claims 118-139 or 156-170, the vectors of any one of claims 140-154 or 171-185, or the cells of claims 117, 155 or 186, wherein the edits introduce one or more modifications to the nucleic acid molecule and, wherein the one or more modifications are associated with reducing, relieving, or preventing the symptoms of a disease or disorder.

206. The method of claim 205, wherein the disease or disorder is selected from the group consisting of CNS disorders, liver disorders and ocular disorders.

207. A pharmaceutical composition comprising the virus-like particle of any one of claims 1-116, the polynucleotides of any one of claims 118-139 or 156-170, the vectors of any one of claims 140-154 or 171-185, or the cells of claims 117, 155 or 186, and a pharmaceutical excipient.

208. The virus-like particle of claim 114, wherein the cargo protein is a base editor or a prime editor.

209. The method of any one of claims 187-194, wherein the method is performed in vivo or in vitro.

210. A fusion protein comprising a nucleic acid sequence that is at least 80%, at least 85%, at least 90%, at least 95%, at least 98%, at least 99%, at least 99.5%, or at least 100% identical to the nucleic acid sequence of any one of SEQ ID NOs: 89-199 or 534-892.

211. A polynucleotide encoding the fusion protein of claim 210.