[go: up one dir, main page]

WO2024254274A3 - Bioprinting of hierarchically branching microvascular networks - Google Patents

Bioprinting of hierarchically branching microvascular networks Download PDF

Info

Publication number
WO2024254274A3
WO2024254274A3 PCT/US2024/032760 US2024032760W WO2024254274A3 WO 2024254274 A3 WO2024254274 A3 WO 2024254274A3 US 2024032760 W US2024032760 W US 2024032760W WO 2024254274 A3 WO2024254274 A3 WO 2024254274A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood supply
hierarchically
native
branching
perfuse
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/032760
Other languages
French (fr)
Other versions
WO2024254274A2 (en
Inventor
Ryan Hooper
David Dean
Ciro RODRIGUEZ
Javier Vazquez ARMENDARIZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ohio State Innovation Foundation
Original Assignee
Ohio State Innovation Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ohio State Innovation Foundation filed Critical Ohio State Innovation Foundation
Publication of WO2024254274A2 publication Critical patent/WO2024254274A2/en
Publication of WO2024254274A3 publication Critical patent/WO2024254274A3/en
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
    • B29C64/112—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/20—Apparatus for additive manufacturing; Details thereof or accessories therefor
    • B29C64/205—Means for applying layers
    • B29C64/209—Heads; Nozzles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Manufacturing & Machinery (AREA)
  • Mechanical Engineering (AREA)
  • Optics & Photonics (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

A challenge to the clinical viability of large-scale tissue engineering is being able to perfuse entire constructs with blood supply that persists long-term. To accomplish this, tissue engineering needs to replicate the hierarchically branching networks of microvasculature that distribute homogeneous blood supply from arteries to capillary beds in natural tissues. Chaotic Printing can be adapted to extruding wide sheets of hydrogel containing hierarchically branching layers of multiple cell types that are native to vascular tissue. An in vitro "prevascularization" period can allow these cells to form into hollow tubular structures that mimic native microvasculature and can be perfused with blood supply. These prevascularized sheets can then be implanted in a subject to integrate with native arteries and veins and perfuse injured tissue with new blood supply.
PCT/US2024/032760 2023-06-06 2024-06-06 Bioprinting of hierarchically branching microvascular networks Pending WO2024254274A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202363506507P 2023-06-06 2023-06-06
US63/506,507 2023-06-06
US202363604956P 2023-12-01 2023-12-01
US63/604,956 2023-12-01

Publications (2)

Publication Number Publication Date
WO2024254274A2 WO2024254274A2 (en) 2024-12-12
WO2024254274A3 true WO2024254274A3 (en) 2025-01-16

Family

ID=93794680

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/032760 Pending WO2024254274A2 (en) 2023-06-06 2024-06-06 Bioprinting of hierarchically branching microvascular networks

Country Status (1)

Country Link
WO (1) WO2024254274A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150027625A1 (en) * 2007-12-12 2015-01-29 3M Innovative Properties Company Hydrophilic gel materials and methods of making
US20170157844A1 (en) * 2015-12-08 2017-06-08 Xerox Corporation Extrusion printheads for three-dimensional object printers
US20220290086A1 (en) * 2019-09-27 2022-09-15 Ohio State Innovation Foundation Methods and systems for cell culture
WO2022258936A1 (en) * 2021-06-06 2022-12-15 Copner Biotech Ltd Additive manufacturing using low viscosity materials

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150027625A1 (en) * 2007-12-12 2015-01-29 3M Innovative Properties Company Hydrophilic gel materials and methods of making
US20170157844A1 (en) * 2015-12-08 2017-06-08 Xerox Corporation Extrusion printheads for three-dimensional object printers
US20220290086A1 (en) * 2019-09-27 2022-09-15 Ohio State Innovation Foundation Methods and systems for cell culture
WO2022258936A1 (en) * 2021-06-06 2022-12-15 Copner Biotech Ltd Additive manufacturing using low viscosity materials

Also Published As

Publication number Publication date
WO2024254274A2 (en) 2024-12-12

Similar Documents

Publication Publication Date Title
Sengupta et al. From in vitro to in situ tissue engineering
Sodian et al. Tissue-engineering bioreactors: a new combined cell-seeding and perfusion system for vascular tissue engineering
Niklason Replacement arteries made to order
Vacanti Beyond transplantation: third annual Samuel Jason Mixter lecture
US11648103B2 (en) Artificial vascular graft
Jordan et al. Bioengineered self-seeding heart valves
Naito et al. Successful clinical application of tissue-engineered graft for extracardiac Fontan operation
Mangir et al. Current state of urethral tissue engineering
Cicha et al. Biofabrication of vessel grafts based on natural hydrogels
CN108498867B (en) Method for manufacturing three-dimensional small-caliber blood vessel model
Kajbafzadeh et al. Three-year efficacy and patency follow-up of decellularized human internal mammary artery as a novel vascular graft in animal models
ES2699690T3 (en) Prevascularized devices and related methods
Sahakyants et al. Tissue engineering: from the bedside to the bench and back to the bedside
Mertsching et al. Bioreactor technology in cardiovascular tissue engineering
Sterpetti et al. Healing of high-porosity polytetrafluoroethylene arterial grafts is influenced by the nature of the surrounding tissue
WO2024254274A3 (en) Bioprinting of hierarchically branching microvascular networks
Zhen et al. Synthetic vascular graft that heals and regenerates
Singha et al. Cardio vascular grafts: existing problems and proposed solutions
RU2445940C1 (en) Method for producing allogenic transplants of cardiac vessels with valves
Gill et al. Future perspectives in bladder tissue engineering
WO2000035372A2 (en) Multiple matrices for engineered tissues
Tang et al. Future directions for research on tissue-engineered trachea
TWM507742U (en) The guided nerve conduit
He et al. Newly designed compliant hierarchic hybrid vascular graft wrapped with microprocessed elastomeric film—II: morphogenesis and compliance change upon implantation
CN108245712A (en) The preparation method and application of bacteria cellulose minor diameter artificial blood vessel