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WO2024254188A3 - Methods for treating enteric injury - Google Patents

Methods for treating enteric injury Download PDF

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Publication number
WO2024254188A3
WO2024254188A3 PCT/US2024/032607 US2024032607W WO2024254188A3 WO 2024254188 A3 WO2024254188 A3 WO 2024254188A3 US 2024032607 W US2024032607 W US 2024032607W WO 2024254188 A3 WO2024254188 A3 WO 2024254188A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
injury
food
treating
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/032607
Other languages
French (fr)
Other versions
WO2024254188A2 (en
Inventor
David Kyle
Minhthy Nguyen
Karl Sylvester
Bethany HENRICK
Britta HEISS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Infinant Health Inc
Original Assignee
Infinant Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infinant Health Inc filed Critical Infinant Health Inc
Publication of WO2024254188A2 publication Critical patent/WO2024254188A2/en
Publication of WO2024254188A3 publication Critical patent/WO2024254188A3/en
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A61K2035/115—Probiotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Nutrition Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)

Abstract

The technology described herein is directed to medicament compositions and methods of monitoring, treating, and preventing a non-IgE food allergy such as Food Protein Induced Allergenic Proctocolitis (FPIAP) or Food Protein Induced Enterocolitis Syndrome (FPIES). The medicament can comprise bacteria such as Bifidobacterium strains, or bioproducts thereof, in order to increase expression of certain HMO utilization genes (HUGs) considered protective against food allergy.
PCT/US2024/032607 2023-06-05 2024-06-05 Methods for treating enteric injury Pending WO2024254188A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363471087P 2023-06-05 2023-06-05
US63/471,087 2023-06-05

Publications (2)

Publication Number Publication Date
WO2024254188A2 WO2024254188A2 (en) 2024-12-12
WO2024254188A3 true WO2024254188A3 (en) 2025-05-15

Family

ID=93794686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/032607 Pending WO2024254188A2 (en) 2023-06-05 2024-06-05 Methods for treating enteric injury

Country Status (1)

Country Link
WO (1) WO2024254188A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190076490A1 (en) * 2012-11-02 2019-03-14 N.V. Nutricia Synbiotics combination for brain improvement
US20220010267A1 (en) * 2018-05-30 2022-01-13 Evolve Biosystems, Inc. Compostions and method of use for h5 competent bifidobacterium longum subsp. infantis
WO2022026483A2 (en) * 2020-07-27 2022-02-03 Evolve Biosystems, Inc. Microbiome mediated induction of immune tolerance and resolution of inflammation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190076490A1 (en) * 2012-11-02 2019-03-14 N.V. Nutricia Synbiotics combination for brain improvement
US20220010267A1 (en) * 2018-05-30 2022-01-13 Evolve Biosystems, Inc. Compostions and method of use for h5 competent bifidobacterium longum subsp. infantis
WO2022026483A2 (en) * 2020-07-27 2022-02-03 Evolve Biosystems, Inc. Microbiome mediated induction of immune tolerance and resolution of inflammation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DUPONT CHRISTOPHE, DUPONT CHRISTOPHE, DUPONT CHRISTOPHE, , : "Food Protein-Induced Enterocolitis Syndrome and Proctocolitis", ANNALS OF NUTRITION AND METABOLISM: EUROPEAN JOURNAL OF NUTRITION, METABOLIC DISEASES AND DIETETICS, S. KARGER AG, SWITZERLAND, vol. 73, no. Suppl. 4, 1 January 2018 (2018-01-01), Switzerland , pages 8 - 16, XP093314497, ISSN: 0250-6807, DOI: 10.1159/000493671 *
KIMURA MITSUAKI, ITO YASUNORI, SHIMOMURA MASAKI, MORISHITA HIDEAKI, MEGURO TAKAAKI, ADACHI YUICHI, SETO SHIRO: "Cytokine profile after oral food challenge in infants with food protein-induced enterocolitis syndrome", ALLERGOLOGY INTERNATIONAL, JAPANESE SOCIETY OF ALLERGOLOGY, JP, vol. 66, no. 3, 1 July 2017 (2017-07-01), JP , pages 452 - 457, XP093314512, ISSN: 1323-8930, DOI: 10.1016/j.alit.2016.12.001 *
MUGARAB-SAMEDI VERONICA, HOWLETT ALIXE, HICKS MATTEW, ARRIETA MARIE-CLAIRE, BEAUDRY PAUL, DERSCH-MILLS DEONNE, ALSHAIKH BELAL: "Probiotics supplementation and length of hospital stay in neonates with gastrointestinal surgery", INTERNATIONAL JOURNAL OF SURGERY PROTOCOLS, vol. 6, no. 0, 1 January 2017 (2017-01-01), pages 13 - 16, XP093314515, ISSN: 2468-3574, DOI: 10.1016/j.isjp.2017.10.001 *
PATWARDHAN GAURAV, SONI ANKIT, RACHWANI NITIN, KADAM SANDEEP, PATOLE SANJAY, PANDIT ANAND: "Factors Associated with Time to Full Feeds in Preterm Very Low Birth Weight Infants", JOURNAL OF TROPICAL PEDIATRICS, LONDON, GB, vol. 64, no. 6, 1 December 2018 (2018-12-01), GB , pages 495 - 500, XP093314514, ISSN: 0142-6338, DOI: 10.1093/tropej/fmx102 *

Also Published As

Publication number Publication date
WO2024254188A2 (en) 2024-12-12

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