[go: up one dir, main page]

WO2024253689A1 - Applicateur de lumière à étalonnage automatique - Google Patents

Applicateur de lumière à étalonnage automatique Download PDF

Info

Publication number
WO2024253689A1
WO2024253689A1 PCT/US2023/068117 US2023068117W WO2024253689A1 WO 2024253689 A1 WO2024253689 A1 WO 2024253689A1 US 2023068117 W US2023068117 W US 2023068117W WO 2024253689 A1 WO2024253689 A1 WO 2024253689A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
therapy
detectors
processor
optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2023/068117
Other languages
English (en)
Inventor
Trevor Macdougall
Michael Haines
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lumeda Inc
Original Assignee
Lumeda Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lumeda Inc filed Critical Lumeda Inc
Priority to PCT/US2023/068117 priority Critical patent/WO2024253689A1/fr
Publication of WO2024253689A1 publication Critical patent/WO2024253689A1/fr
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0626—Monitoring, verifying, controlling systems and methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres

Definitions

  • the present disclosure relates to photodynamic therapy.
  • Light therapy can be used for the treatment of diseased-state conditions in multiple ways.
  • light therapies involve the delivery of a therapeutic light through a fiber optic device placed proximal to or within a target tumor.
  • Light therapies can be combined with prior administration of light sensitizing medication (i.e., photosensitizer) that absorbs the therapeutic light and interacts with surrounding tissue constituents (e.g., oxygen) to generate reactive species that can destroy the target tissue.
  • light sensitizing medication i.e., photosensitizer
  • surrounding tissue constituents e.g., oxygen
  • PDT photodynamic therapy
  • a system of one or more computers can be configured to perform particular operations or actions by virtue of having software, firmware, hardware, or a combination of them installed on the system that in operation causes or cause the system to perform the actions.
  • One or more computer programs can be configured to perform particular operations or actions by virtue of including instructions that, when executed by data processing apparatus, cause the apparatus to perform the actions.
  • an The optical light delivery system may include a diagnostic system having a plurality of therapy light sources, a plurality of light diffusers, each one of the plurality of light diffusers coupled to a respective one of the plurality of therapy light sources, a plurality of light detectors, each configured to measure a light output of a respective one of the plurality of light diffuser and therapy light source combinations, and a processor configured to perform a diagnostic routine to compare the light output measured by each of the plurality of light detectors for each of the plurality of therapy light source and diffuser combinations.
  • Other embodiments of this aspect include corresponding computer systems, apparatus, and computer programs recorded on one or more computer storage devices, each configured to perform the actions of the methods.
  • Implementations may include one or more of the following features.
  • the optical light delivery system where the diagnostic routine is further configured to identify any variations in the light output among the plurality of therapy light sources and diffuser combinations.
  • the optical light delivery system where the diagnostic routine is further configured to provide feedback to adjust the light output of each therapy light source and diffuser combination to achieve a substantially equal light output amongst each therapy light source and diffuser combination.
  • the optical light delivery system where each of the plurality of light detectors is configured to measure an intensity and a wavelength of the light output emitted by each of the plurality of therapy light sources and diffuser combinations.
  • the optical light delivery system where the therapy light sources are configured to emit light at a predetermined wavelength.
  • the optical light delivery system where the light diffusers are configured to diffuse light emitted by the therapy light sources to provide an uniform light output.
  • the optical light delivery system may include a controller configured to control the plurality of therapy light sources, where the diagnostic routine is configured to optimize the performance of the plurality of therapy light sources and diffuser combinations, and where the controller is configured to adjust the plurality of therapy light sources to produce an irradiance pattern in accordance with a predetermined therapy plan.
  • the optical light delivery system may include a plurality of optical delivery fibers directly coupling the plurality of therapy light sources to a respective one of the plurality of light diffusers, a plurality of driver boards are coupled to the processor and are coupled to a respective one of the plurality of therapy light sources, where the plurality of light detectors may include a plurality of optical fiber detectors directly coupled to a respective one of a plurality of opto-electronic detectors, a conformal light applicator having longitudinal channels where the plurality of light diffusers are disposed in a respective longitudinal channel and where a respective one of the plurality of optical fiber detectors is disposed adjacent to the plurality of light diffusers, where the plurality of optoelectronic detectors is coupled to the processor, where the plurality of opto-electronic detectors are configured to produce a plurality of output signals to the plurality of driver boards, and where the processor is further configured to use plurality of output signals to perform the diagnostic routine.
  • the optical light delivery system where the diagnostic routine is configured to determine a state of any of the plurality of light diffusers.
  • the optical light delivery system may include a diagnostic light shield having a top portion and a bottom portion and forming a cavity in a lock position, and where the conformal light applicator is positioned within the cavity to perform the diagnostic routine.
  • a method may include providing a diagnostic system having providing a plurality of therapy light sources, coupling a plurality of light diffusers to a respective one of the plurality of therapy light sources, coupling a plurality of light detectors to a respective one of the plurality of light diffuser and therapy light source combinations, measuring with the plurality of light detectors a light output of a respective one of the plurality of light diffuser and therapy light source combinations, and performing with a processor a diagnostic routine by comparing the light output measured by each of the plurality of light detectors for each of the plurality of therapy light source and diffuser combinations.
  • Other embodiments of this aspect include corresponding computer systems, apparatus, and computer programs recorded on one or more computer storage devices, each configured to perform the actions of the methods.
  • Implementations may include one or more of the following features.
  • the method may include identifying any variations in the light output among the plurality of therapy light sources and diffuser combinations.
  • the method may include providing feedback to the processor, and adjusting the light output of each therapy light source and diffuser combination to achieve a substantially equal light output amongst each therapy light source and diffuser combination.
  • the method may include measuring with the plurality of light detectors is an intensity and a wavelength of the light output emitted by each of the plurality of therapy light sources and diffuser combinations.
  • the method emitting light at a predetermined wavelength from the therapy light sources.
  • the method may include diffusing light emitted by the therapy light sources and providing an uniform light output.
  • the method may include providing a controller to control the plurality of therapy light sources, optimizing, using the diagnostic routine, the performance of the plurality of therapy light sources and diffuser combinations, adjusting, using the controller, the plurality of therapy light sources, and producing an irradiance pattern in accordance with a predetermined therapy plan.
  • the method may include coupling the plurality of therapy light sources to a respective one of the plurality of light diffusers using a plurality of optical delivery fibers, coupling a plurality of driver boards to the processor and a respective one of the plurality of therapy light sources, directly coupling the plurality of light detectors to a respective one of a plurality of opto-electronic detectors using a plurality of optical detector fiber detectors directly coupled to a respective one of a plurality of opto-electronic detectors, providing a conformal light applicator having longitudinal channels, disposing the plurality of light diffusers in a respective longitudinal channel, and disposing a respective one of the plurality of optical fiber detectors adjacent to the plurality of light diffusers, coupling the plurality of opto-electronic detectors to the processor, producing a plurality of output signals using the plurality of opto-electronic detectors and outputting the plurality of output signals to the plurality of driver boards, and performing the diagnostic routine using plurality of output signals
  • the method determining, with the diagnostic routine, a state of any of the plurality of light diffusers.
  • the method may include providing a diagnostic light shield having a top portion and a bottom portion and forming a cavity in a lock position, positioning the conformal light applicator is positioned within the cavity, and performing the diagnostic routine.
  • a device may include a storage device, and a processor executing program instructions stored in the storage device and being configured to provide a diagnostic system having provide a plurality of therapy light sources couple a plurality of light diffusers to a respective one of the plurality of therapy light sources couple a plurality of light detectors to a respective one of the plurality of light diffuser and therapy light source combinations measure with the plurality of light detectors a light output of a respective one of the plurality of light diffuser and therapy light source combinations, and perform with a processor a diagnostic routine by comparing the light output measured by each of the plurality of light detectors for each of the plurality of therapy light source and diffuser combinations.
  • Other embodiments of this aspect include corresponding computer systems, apparatus, and computer programs recorded on one or more computer storage devices, each configured to perform the actions of the methods.
  • Implementations may include one or more of the following features.
  • the device where the processor is further configured to identify any variations in the light output among the plurality of therapy light sources and diffuser combinations.
  • the device where the processor is further configured to provide feedback to the processor, and adjust the light output of each therapy light source and diffuser combination to achieve a substantially equal light output amongst each therapy light source and diffuser combination.
  • the device where the processor is further configured to measure with the plurality of light detectors is an intensity and a wavelength of the light output emitted by each of the plurality of therapy light sources and diffuser combinations.
  • the device where the processor is further configured to emit light at a predetermined wavelength from the therapy light sources.
  • the device where the processor is further configured to diffuse light emitted by the therapy light sources and providing an uniform light output.
  • the device where the processor is further configured to provide a controller to control the plurality of therapy light sources, optimize, using the diagnostic routine, the performance of the plurality of therapy light sources and diffuser combinations, adjust, using the controller, the plurality of therapy light sources, and produce an irradiance pattern in accordance with a predetermined therapy plan.
  • the device where the processor is further configured to couple the plurality of therapy light sources to a respective one of the plurality of light diffusers using a plurality of optical delivery fibers, couple a plurality of driver boards to the processor and a respective one of the plurality of therapy light sources, directly couple the plurality of light detectors to a respective one of a plurality of opto-electronic detectors using a plurality of optical fiber detectors directly coupled to a respective one of a plurality of opto-electronic detectors, provide a conformal light applicator having longitudinal channels, dispose the plurality of light diffusers in a respective longitudinal channel, and dispose a respective one of the plurality of optical fiber detectors adjacent to the plurality of light diffusers, couple the plurality of opto-electronic detectors to the processor, produce a plurality of output signals using the plurality of opto-electronic detectors and outputting the plurality of output signals to the plurality of driver boards, and perform the diagnostic routine using the plurality of output signals.
  • the device where the processor is further configured to determine, with the diagnostic routine, a state of any of the plurality of light diffusers.
  • the device where the processor is further configured to provide a diagnostic light shield having a top portion and a bottom portion and forming a cavity in a lock position, position the conformal light applicator is positioned within the cavity, and perform the diagnostic routine.
  • Figure 1 is a schematic representation of a PDT system in accordance with the present invention.
  • Figure 2 is an isometric view of a conformal light applicator of a PDT delivery system in accordance with the present invention
  • Figure 3 is an isometric view of a conformal light applicator and optical cable of a PDT delivery system in accordance with the present invention
  • Figure 4 is an isometric view of a diagnostic light shield of a PDT delivery system in accordance with the present invention.
  • Figure 5 is an isometric view of a diagnostic light shield of a PDT delivery system in accordance with the present invention.
  • the present disclosure relates to an optical light therapy application and monitoring system which can be configured to optimized for a particular PDT procedure and can produce a known and controllable dosimetry. Such a system is useful in the treatment of cancerous tumors as well as residual abnormal tissue following surgical resection of a tumor.
  • the present disclosure includes a customizable conformal light applicator (CLA) and a conformal light applicator signal monitoring system.
  • FIG. 1 there is shown a PDT delivery system 1 comprising a plurality of CLDs 2, 3, 4, 5 positioned within conformal light applicator 25.
  • CLDs 121a- 121 d can comprise flexible cylindrical optical diffusers that are configured to diffuse light produced by a therapy light source as will be disclosed in more detail herein after.
  • this embodiment includes four cylindrical light diffusers (CLDs) 2, 3, 4, 5, other embodiments are contemplated having N diffusers wherein N can be four, more than four and fewer than four.
  • PDT delivery system 1 further includes therapy light sources 6, 7, 8, 9 respectively directly optically coupled to CLDs 2, 3, 4, 5 by respective optical delivery fibers 34-37 to produce unique light diffuser and therapy light source combinations.
  • Therapy light sources 6, 7, 8, 9 can comprise lasers, light emitting diodes or other suitable light source.
  • PDT delivery system 1 further includes driver boards 10, 11 , 12, 13 respectively electrically coupled to therapy light sources 6, 7, 8, 9 and to power supply 14.
  • PDT delivery system 1 also includes light detectors in the form of optical fiber detectors 15, 16, 17, 18 positioned respectively proximate CLDs 2, 3, 4, 5 and respectively coupled to opto-electronic detectors 19, 20, 21 , 22.
  • PDT delivery system 1 further includes processor 23 including a storage device and configured to execute program instructions.
  • Processor 23 can comprise an interface to electrically couple opto-electronic detectors 19-22 and driver boards 10-13 to a controller to control and adjust therapy light sources 6, 7, 8, 9 to produce substantially a uniform and equal light output amongst CLDs 2, 3, 4, 5.
  • Opto-electronic detectors 19-22 are configured to provide output signals indicative of a measurement of the intensity of the therapy light as well as the wavelength of the therapy emitted from CLDs 2, 3, 4, 5.
  • Processor 23 can comprise an RS232 interface and a computer processer capable of storing data and running software to perform the functions disclosed herein.
  • PDT delivery system 1 optionally includes cooling device 24 electrically coupled to power supply 14 to maintain therapy light sources 6-9 at a predetermined operating temperature.
  • Cooling device 24 can comprise a thermoelectric cooler and a heat sink or other suitable cooling device capable of maintaining therapy light sources 6-9 at a predetermined operating temperature.
  • various components of PDT delivery system 1 constitute an “instrument” for purposes of this disclosure. Still referring to FIG. 1 , such components comprising an instrument include therapy light sources 6-9, driver boards 10-13, power supply 14, opto-electronic detectors 19-22 and processor 23 in addition to the optical delivery fibers 34-37 and electronics coupling the various components.
  • a predetermined therapy plan can be determined for a target area of a patient that includes a predetermined wavelength of the therapy light, a desired irradiance pattern and optical dosimetry (dosimetry) for the pattern.
  • the therapy plan can be entered into processor 23 where algorithms, which are disclosed in more detail herein after, can determine optimum control of the therapy light sources 6-9 to produce a desired irradiance pattern and dosimetry from the plurality of CLDs 2-5.
  • the conformal light applicator 25 can be positioned against the target area of patient and oriented using methods disclosed herein or other suitable methods.
  • conformal as it relates to conformal light applicator 25, means that when the conformal light applicator is applied to a target area the size and area of the therapy light projected therefrom remains unchanged due to any curvature of the conformal light applicator.
  • the therapy plan is started by driver boards 10-13 sending a respective start condition control signal to therapy light sources 6-9 intended to produce the desired initial irradiance pattern and dosimetry.
  • Each of the plurality of CLDs 2-5 provides a monitoring light signal to the respective optical detector fibers 15-18 and to opto-electronic detectors 19-22 in real time.
  • Diagnostic routines can be performed on the operation of PDT delivery system 1 wherein opto-electronic detectors 19-22 provide a respective monitoring signal to processor 23 wherein the processor runs algorithms as will be disclosed in more detail herein after with reference to Equations 1 -5.
  • processor 23 compares the start condition control signals to the monitoring signals and sends a respective updated control signal to each of the CLDs 2-5. It is important to note that not all of the plurality of CLDs 2-5 may be necessary at any point in time during the operation of PDT delivery system 1.
  • the operation of monitoring, comparing and delivering of therapy light is continued until the therapy plan is completed within acceptable limits. Such acceptable limits can be pre-programmed into processor 23 or can be input into the processor by a user.
  • cooling device 24 limits drift that can occur when lasers are operated for extended periods and can therefore remove one of the variables that can cause PDT delivery system 1 from producing a desired irradiance pattern and dosimetry in accordance with the therapy plan. It should be further noted that the use of CLDs 2-5 enables The optical light delivery system to monitor each of the plurality of light emitting sources in real time taking into account the actual performance of each leg of the PDT delivery system 1 .
  • CLA 25 including a plurality of longitudinal channels.
  • CLA 25 includes four parallel longitudinal CLD channels 26-29. Longitudinal CLD channels 26-29 are configured to have CLDs 2-5 (FIG. 1 ) respectively disposed therein.
  • CLA 25 further includes four parallel longitudinal detector channels 30-33 positioned adjacent to and proximate CLD channels 26-29. Longitudinal detector channels 30-33 are configured to have optical detector fibers 15-18 (FIG. 1 ) respectively disposed therein.
  • Channels 26-29 are shown as evenly distributed across the width of CLA 25 and are positioned at the same distance from the bottom surface of the flap.
  • An optical cable (41 , FIG. 3) can contain the optical fibers delivering therapy light to the CLDs 2-5 from the sources 6-9 and the optical fibers collecting the monitoring light from the optical fiber detectors 15-18 and delivering it to the opto-electronic detectors 19-22.
  • the optical cable 41 can be sealed to CLA 25 by applying a medical grade shrink tube.
  • a user can run the diagnostics disclosed herein after and subsequently perform a PDT procedure by placing CLA 25 against an area of interest of a patient.
  • the placement of conformal light applicator 25 can be based on an image of a tumor, resection area or other image of a patient for a target area of PDT treatment.
  • the image can be a CAT scan, a PET scan, an x-ray, an MRI scan and the like.
  • the image can comprise a digital file and the digital file can used to preset the location of the conformal light applicator 25.
  • processor 23 includes algorithms configured to use the light collected by the detector fibers to control the overall irradiance pattern as well as the individual source CLDs 2-5 to match the dosimetry called out in the therapy plan.
  • CLA 25 coupled to optical cable 41.
  • CLA 25 includes a plurality of CLDs 2-5 and a plurality of optical detector fibers 15-18 as disclosed herein above with reference to FIG. 1 and that this particular example the CLA includes the same four pairs of CLDs and optical detector fibers.
  • a diagnostic light shield 50 which includes bottom portion 51 and top portion 52.
  • Bottom portion 51 comprises a cavity configured to accept CLA 25 and includes staples 54a-54d that cooperate with clasps 53a-53d of top portion 42 respectively to releasably lock the top portion to the bottom portion in a locked position.
  • Top portion 51 further includes top relief 55 and bottom portion includes bottom relief 56.
  • Top relief 55 and bottom relief 56 cooperate to form an aperture within which optical cable 41 can be releasably sealed when CLA 25 is releasably locked within diagnostic light shield 50 in the lock position as shown with reference to FIG. 5.
  • Diagnostic light shield 50 is opaque and is comprised of a light blocking material and is configured to trap light emitted by the CLDs of CLA 25 during diagnostics and testing as will be disclosed in more detail herein after.
  • a user in operation, can produce a diagnostic system utilizing PDT delivery system 1 (FIG. 1 ) by releasably sealing CLA 25 within diagnostic light shield 50 in the lock position (FIG. 5). The user can then characterize any individual CLA using a diagnostics routine as disclosed herein after. As part of an implementation of a diagnostic routine to identify variations in the light output of the CLDs 2-5.
  • each of the CLDs 2-5 is turned on, one at a time and four irradiance values are measured from each isotropic optical detector fiber 15-18 and these four irradiance values are then used, for each individual CLD, to calculate a 4x4 matrix which can then be used to backward calculate the power output values of each individual CLD when all four CLDs are on at the same time.
  • the power output values for each of the CLDs 2-5 can then be controlled using controller 23 to adjust and maintain a target irradiance profile, such as a uniform irradiance profile at the surface of the CLA, and to update target dose values in accordance with the treatment plan.
  • the four measured irradiance values from each CLD powered on separately are arranged in the following matrix:
  • IPN denote the reported respective detector irradiance values and the SN denote the power output values for the respective CLDs 2-5. Solving for the individual output power levels:
  • the controller 23 can then control each laser source 6-9 using respective driver boards 10-13 and CLD combination for the CLA 25 to maintain a desired target irradiance pattern and to update target dose values in accordance with the treatment plan.
  • a vector TN for each of the CLDs 2- 5, can form a matrix MN to interpret the feedback from the optical fiber detectors.
  • a CLA 25 is releasably sealed within diagnostic light shield 50 and each of the 4 CLDs 2-5 are powered on separately and the readings from the 4 respective optical fiber detectors 15-18, are recorded.
  • Each set of optical fiber detector readings can be normalized to an individual CLD power, for example CLD N , and forms one column of a 4X4 matrix, the inverse of which is the first matrix MN, herein after referred to as Mi:
  • the size of the matrix can vary based on the number of optical fiber detectors and of CLDs.
  • the matrix would be an NxN matrix.
  • multiple matrices may be used, or additional information may be combined or assumptions may be added so as to use a single matrix. These matrix values are determined during calibration and then used in the operation of the cable 41 and instrument together as part of the actual treatment diagnostic phase after the cable is attached to the instrument.
  • each normalized reading can be set to 0 if the reading of an individual optical detector fiber is within the limits of a predetermined noise level. If a fiber in optical cable 41 were damaged or not correctly connected to the instrument, a row or column of M' 1 would be only noise and the determinant of Mr 1 should be 0. In operation, setting low readings to 0 would prevent the algorithm from calculating Mi if a fiber were not functioning properly, stopping the algorithm, alerting a user to a problem and requiring the user to address the problem.
  • matrix M2 can be developed for the check during the diagnostics routine to make sure The optical light delivery system is functioning in accordance with the calibrated values measured with Mi. If the values for M2 are within predetermined acceptable limits of the values of Mi, then optical cable 41 would be considered to have passed the diagnostics routine.
  • Ms can be developed which actively calculates CLD power during treatment based on optical detector fiber readings using a similar procedure to that of M2. It should be appreciated by those skilled in the art that the procedure that is disclosed above for comparing Mi to M2 can similarly be used when comparing M3 to M4.
  • Coupled or “operably coupled” are defined as connected, although not necessarily directly, and not necessarily mechanically.
  • scatter, diffuse and spread are among the same terms that similar meaning as delivering total available therapy light to a broader area than that of prior art methods.
  • the terms “a” and “an” are defined as one or more unless stated otherwise.

Landscapes

  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

L'invention concerne un système de diagnostic qui peut comprendre une pluralité de sources de lumière de thérapie; une pluralité de diffuseurs de lumière, chacun de la pluralité de diffuseurs de lumière étant couplé à l'une respective de la pluralité de sources de lumière de thérapie; une pluralité de détecteurs de lumière, chacun étant configuré pour mesurer une sortie de lumière d'une combinaison respective de la pluralité de combinaisons de diffuseur de lumière et de source de lumière de thérapie; et un processeur configuré pour effectuer une routine de diagnostic pour comparer les sorties de lumière mesurées par chacun de la pluralité de détecteurs de lumière pour chacune de la pluralité de combinaisons de source de lumière de thérapie et de diffuseur.
PCT/US2023/068117 2023-06-08 2023-06-08 Applicateur de lumière à étalonnage automatique Pending WO2024253689A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US2023/068117 WO2024253689A1 (fr) 2023-06-08 2023-06-08 Applicateur de lumière à étalonnage automatique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2023/068117 WO2024253689A1 (fr) 2023-06-08 2023-06-08 Applicateur de lumière à étalonnage automatique

Publications (1)

Publication Number Publication Date
WO2024253689A1 true WO2024253689A1 (fr) 2024-12-12

Family

ID=93795956

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/068117 Pending WO2024253689A1 (fr) 2023-06-08 2023-06-08 Applicateur de lumière à étalonnage automatique

Country Status (1)

Country Link
WO (1) WO2024253689A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060095100A1 (en) * 2004-10-29 2006-05-04 Kian Shin Lee Method and apparatus for regulating light administered at a patient treatment site
US20110118547A1 (en) * 2009-11-19 2011-05-19 Fujifilm Corporation Endoscope apparatus
US20170312537A1 (en) * 2014-11-19 2017-11-02 Sharp Kabushiki Kaisha Photodynamic therapy device
WO2021226001A2 (fr) * 2020-05-05 2021-11-11 Lumeda Inc. Système et procédé de dosimétrie multiplexée dans le temps
WO2022260650A1 (fr) * 2021-06-08 2022-12-15 Lumeda Inc. Applicateur de surface optique avec diffuseur intégré
WO2023009110A1 (fr) * 2021-07-28 2023-02-02 Lumeda Inc. Système et procédé de thérapie photodynamique configurable

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060095100A1 (en) * 2004-10-29 2006-05-04 Kian Shin Lee Method and apparatus for regulating light administered at a patient treatment site
US20110118547A1 (en) * 2009-11-19 2011-05-19 Fujifilm Corporation Endoscope apparatus
US20170312537A1 (en) * 2014-11-19 2017-11-02 Sharp Kabushiki Kaisha Photodynamic therapy device
WO2021226001A2 (fr) * 2020-05-05 2021-11-11 Lumeda Inc. Système et procédé de dosimétrie multiplexée dans le temps
WO2022260650A1 (fr) * 2021-06-08 2022-12-15 Lumeda Inc. Applicateur de surface optique avec diffuseur intégré
WO2023009110A1 (fr) * 2021-07-28 2023-02-02 Lumeda Inc. Système et procédé de thérapie photodynamique configurable

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHAMBERLAIN SARAH, BELLNIER DAVID, YENDAMURI SAI, LINDENMANN JOERG, DEMMY TODD, NWOGU CHUKWUMERE, RAMER MAX, TWOREK LARRY, OAKLEY : "An Optical Surface Applicator for Intraoperative Photodynamic Therapy", LASERS IN SURGERY AND MEDICINE., WILEY- LISS, NEW YORK., US, vol. 52, no. 6, 1 July 2020 (2020-07-01), US , pages 523 - 529, XP093249906, ISSN: 0196-8092, DOI: 10.1002/lsm.23168 *

Similar Documents

Publication Publication Date Title
CN100401096C (zh) 放射疗法中的治疗前验证方法和其中使用的检测器
CN1622843B (zh) 用于执行和验证治疗的装置以及所属的控制器计算机
EP0904805A2 (fr) Système et méthode d'irradiation thérapeutique
US20130041249A1 (en) Method for temperature control in magnetic resonance-guided volumetric ultrasound therapy
JP5933155B2 (ja) 対外照射放射線分布マッピングの装置および方法
KR20110039514A (ko) 방사선 요법에서 3ｄ 조사량 추적을 위한 장치와 방법
JP2001503645A (ja) 診断装置
CN101522261A (zh) 用于控制和调节间质性光动力疗法的参数的系统和方法
EP3325096B1 (fr) Système d'administration d'une lumière dosée à un tissu
US20080269568A1 (en) Methods for validating a radiotherapy plan by a dosimetry service
US11786749B2 (en) Time mulitplexed dosimetry system and method
WO2024253689A1 (fr) Applicateur de lumière à étalonnage automatique
US11666778B2 (en) Optical surface applicator with integrated diffuser
US11801395B2 (en) Optical applicator feature optimizer
Bagheri et al. Evaluation of Dose Distribution at the Level of Electronic Portal Imaging Device using Treatment Planning System
US12048508B2 (en) Direct in-vivo tumor imaging using optical applicator
CA3173127C (fr) Optimiseur de caracteristiques d'applicateur optique
WO2024025545A1 (fr) Applicateur de surface optimisé et système de surveillance pour thérapie photodynamique
Ismael et al. A DIFFUSION EQUATION BASED ALGORITHM FOR DETERMINATION OF THE OPTIMAL NUMBER OF FIBERS USED FOR BREAST CANCER TREATMENT PLAN-NING IN PHOTODYNAMIC THERAPY
SE9501278L (sv) System för laserbehandling av tumörer
Amasha et al. A diffusion equation based algorithm for determination of the optimal number of fibers used for breast cancer treatment planning in photodynamic therapy
Wang et al. Robustness of Interstitial Photodynamic Therapy Treatment Planning under Uncertainties in Light Delivery
JP2023157681A (ja) 治療計画システム、治療計画方法及び治療計画プログラム
JP2022529114A (ja) 組織に挿入された光学部材の光減衰を判定するためのシステムおよび方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 23940913

Country of ref document: EP

Kind code of ref document: A1