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WO2024253157A1 - Dispositif de traitement de la peau, procédé d'embellissement et procédé de traitement - Google Patents

Dispositif de traitement de la peau, procédé d'embellissement et procédé de traitement Download PDF

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Publication number
WO2024253157A1
WO2024253157A1 PCT/JP2024/020684 JP2024020684W WO2024253157A1 WO 2024253157 A1 WO2024253157 A1 WO 2024253157A1 JP 2024020684 W JP2024020684 W JP 2024020684W WO 2024253157 A1 WO2024253157 A1 WO 2024253157A1
Authority
WO
WIPO (PCT)
Prior art keywords
collagen
skin
user
khz
tripeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/JP2024/020684
Other languages
English (en)
Japanese (ja)
Inventor
将之 金子
祐希 竹内
謙太朗 山▲崎▼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ya Man Ltd
Original Assignee
Ya Man Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ya Man Ltd filed Critical Ya Man Ltd
Priority to CN202480001352.0A priority Critical patent/CN119486780A/zh
Publication of WO2024253157A1 publication Critical patent/WO2024253157A1/fr
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation

Definitions

  • This disclosure relates to a skin treatment device, a beauty method, and a treatment method.
  • a technique is known in which heat is applied to subcutaneous tissue using techniques such as radiofrequency to shrink collagen fibers, and the collagen density is increased in the process of repairing the shrunken collagen fibers.
  • Patent Document 1 discloses a cosmetic method for promoting cutaneous collagen production, which involves applying a pulsed current to the skin of a subject.
  • the pulsed current is characterized by having a frequency in the range of 1 Hz to 200 Hz.
  • the present disclosure therefore aims to efficiently enhance beauty effects such as improving the firmness of the user's skin and reducing wrinkles.
  • a skin treatment device designed to be used on a user's skin to which any collagen-producing substance, including dipeptides and tripeptides, is applied, and is characterized by being capable of applying an alternating current stimulus of 1.5 kHz or less to the user's skin.
  • the present invention is characterized in that an AC stimulus of 1.5 kHz or less can be applied to the skin of a user to which any collagen-producing substance containing dipeptides and tripeptides has been applied, via the collagen-producing substance.
  • the cosmetic method is characterized by applying an alternating current stimulus of 1.5 kHz or less to a target area of a user to which any collagen-producing substance containing dipeptides and tripeptides has been applied.
  • the treatment method is characterized by applying an alternating current stimulus of 1.5 kHz or less to a target area of a user to which any collagen-producing substance containing dipeptides and tripeptides has been applied.
  • FIG. 2 is a diagram showing a schematic configuration of a skin treatment device.
  • FIG. 1 is an explanatory diagram illustrating an example of use of the skin treatment device.
  • 13 is a bar graph showing the usefulness of applying collagen to the skin and applying AC stimulation using a beauty device in combination. 13 is an image showing the collagen density improving effect.
  • 1 is a test result (part 1) showing the frequency dependence of changes in collagen density.
  • 2 is a test result (part 2) showing the frequency dependence of changes in collagen density.
  • 13 is a test result (part 3) showing the frequency dependence of changes in collagen density.
  • 4 is a test result (part 4) showing the frequency dependence of changes in collagen density.
  • FIG. 1 is a diagram summarizing the test method.
  • FIG. 11 is a diagram summarizing other test methods.
  • FIG. 2 is a diagram showing an example of a composition table.
  • the skin treatment device 1 is designed to be used on the skin of a user to which any collagen-producing substance, including dipeptides and tripeptides, has the ability to apply an alternating current stimulus of 1.5 kHz or less to the user's skin.
  • the method of applying the collagen-producing substance to the user's skin is arbitrary, and may involve direct application or contacting the user's skin with cotton or a sheet containing the collagen-producing substance. The following mainly describes "application,” but other application methods may be used instead of application.
  • a skin treatment device 1 that can apply an AC stimulus of 1.5 kHz or less to a user's skin that has been given any collagen-producing substance, including dipeptides and tripeptides, via the collagen-producing substance.
  • This is a treatment method in which an alternating current stimulus of 1.5 kHz or less is applied to a target area of a user to which any collagen-producing substance containing dipeptides and tripeptides has been applied.
  • the skin treatment device 1 may take various forms, such as a mask type or a portable type that is held by the user.
  • a conductive material has first and second sheet electrodes 2a and 2b.
  • the first and second sheet electrodes 2a and 2b are independent of each other and can be attached to any part of the skin 7 by the user.
  • the first and second sheet electrodes 2a and 2b are electrically connected to the current generating unit 4 by the cable 3.
  • the cable 3 has first and second branch cables 3a and 3b that are bifurcated.
  • the first and second branch cables 3a and 3b are connected to the first and second sheet electrodes 2a and 2b, respectively.
  • the cable 3 has a common pin jack or pin plug at the other end for connection to the current generating unit 4.
  • the current generating unit 4 applies an AC stimulus of 1.5 kHz or less to the target part of the user.
  • the conductive material may be any material, such as a conductive polymer, carbon black, resin, dielectric elastomer actuator (DEA), IPMC actuator, PVC gel, etc., that has flexibility so that it can conform to the contours of the skin. It may also be thin enough to be attached to the user's skin, transparent so that it is not noticeable when worn, and may be in a form that matches the color of the user's skin.
  • the conductive material may be reusable or disposable, and it may be possible to apply makeup or sunscreen over it.
  • the conductive material may itself be adhesive, or may have an adhesive layer for attaching it to the user's skin to the extent that the pulse wave having the frequency of the present invention can be applied to the skin.
  • the conductive material may be attached to the skin by providing an adhesive layer on the device, by providing the device with a mounting part such as a belt, or by the adhesiveness of the sheet electrode.
  • a drug layer may be disposed between the conductive layer and the adhesive layer.
  • a microneedle layer having microneedles made of hyaluronic acid or the like may be included.
  • the microneedle layer may be provided on the adhesive layer on the opposite side to the conductive layer, that is, on the surface that contacts the user's skin.
  • the adhesive layer used in the electrode may be any material that has a holding power when adhered to the skin and does not cause pain when removed, and is provided on one surface of the support by means of coating, impregnation, adhesion, casting, etc.
  • Preferred examples of adhesive components include various water-soluble polymers, oil-soluble polymers, or gel agents obtained by partially modifying these by means of crosslinking, etc.
  • the type of crosslinker, the compounding amount, and the compounding conditions can be selected from known methods.
  • Figure 3 is a bar graph showing the usefulness of applying collagen to the skin and applying AC stimulation using a beauty device in combination.
  • test results for each body part are shown in bar graphs.
  • the three bar graphs for each body part represent the results before use, four weeks after use, and eight weeks after use, respectively.
  • the vertical axis is collagen density (Intensity). Note that applying collagen is synonymous with applying cosmetics that contain collagen.
  • a table is shown below the bar graphs in Figure 3, which indicates the rate of change in collagen density when the value before use is taken as 100%.
  • Figure 4 shows the test results indicating whether there is a significant difference in collagen density in the dermis layer when collagen is applied in combination with a facial beauty device (C40) and when collagen is only applied (C42).
  • C40 a facial beauty device
  • C42 collagen only applied
  • graph G51 shows the control (no special actions (such as application of cosmetics or use of equipment) were taken during the test period), and the rest are as follows.
  • Graph G52 Only collagen was applied.
  • Graph G53 Only a base not containing a collagen-producing substance was applied, and then 1 kHz was applied.
  • Graph G54 Collagen was applied, and then 1 kHz was applied.
  • FIG. 5 it can be seen that applying an alternating current stimulus to active ingredients such as collagen-producing substances promotes an increase in collagen density, and that this effect depends on the frequency of the alternating current stimulus.
  • Figure 7 shows the test results when using the same collagen as above. From this, it can be seen that there is no significant effect at frequencies above 1.5 kHz, such as 2 kHz, but the effect is good at 1 Hz to 9 Hz.
  • Figure 7 is a test on subjects of a different gender from the test performed in Figure 6.
  • the test in Figure 7 compares graphs from the following four tests over a four-week period (denoted as "4w"):
  • Graph G71 Only collagen is applied, no application
  • Graph G72 Collagen is applied and then ultra-low frequency of 1 Hz to 9 Hz is applied
  • Graph G73 Collagen is applied and then 2 kHz medium frequency (with bodily sensation) is applied
  • Figure 7 shows that the frequency of the applied AC stimulation is superior to 2 kHz when it is an ultra-low frequency of 1 Hz to 9 Hz.
  • the frequency of the applied AC stimulation is superior to the ultra-low frequency of 1 Hz to 9 Hz when it is an intermediate frequency range centered around 1 kHz or a low frequency of 10 to 50 Hz.
  • Figure 8 is a study on subjects of the same gender as the study conducted in Figure 7.
  • the study in Figure 8 compares graphs from four studies over a four-week period (denoted as "4w"): Graph G81: Only collagen is applied, no application Graph G82: After collagen is applied, 0.5kHz medium frequency is applied Graph G83: After collagen is applied, 1kHz medium frequency is applied Graph G84: After collagen is applied, 1.5kHz medium frequency is applied From Figure 8, it can be seen that there is a tendency for collagen density to improve at 0.5kHz, but the effect is not as great as at 1kHz and 1.5kHz. In addition, there is no significant difference between 1kHz and 1.5kHz, and both have good effects.
  • the frequencies of the applied AC stimuli are predominantly in the mid-frequency range centered around 1 kHz to 1.5 kHz and low frequencies between 10 and 50 Hz.
  • FIG. 9 shows the test method for the test described above with reference to FIG. 6.
  • the test method shown in FIG. 7 etc. is substantially similar, and only the frequency of the AC stimulation is different.
  • the details of the test method are arbitrary and may be changed as appropriate.
  • the test conditions for FIG. 3 and FIG. 4 are shown in FIG. 9A.
  • Cosmetics / Amount to be used Collagen derived from fish diluted with an aqueous solution containing thickening and conductive ingredients.
  • Aqueous solution containing thickening and conductive ingredients only (contains moisturizing ingredients such as glycerin) / 1.0 ml per 5 cm x 5 cm test area.
  • Measuring method After washing with face wash, leave to acclimate for 10 minutes. Collect 9 points for intensity, 3-5 points for stratum corneum moisture content, and 2-4 points for skin elasticity. Average values are used for stratum corneum moisture content, skin elasticity, and intensity.
  • the embodiment may be other than a sheet-type electrode having an adhesive layer, and after any collagen-producing substance including collagen, dipeptides and tripeptides is applied to the skin, an AC stimulus may be applied using a facial beauty device equipped with at least a pair of electrodes in the head portion, or a sheet mask or cotton soaked in any collagen-producing substance including collagen, dipeptides and tripeptides may be placed in close contact with the skin, and then a sheet-type electrode or a mask-type electrical device capable of applying an electric current may be attached from above.
  • a conductive ink may be printed on a sheet-like material such as a nonwoven fabric that can retain moisture, and after soaking it in a collagen production substance, electricity may be applied to the sheet-like material, which is then applied to the skin via the conductive ink.
  • Any collagen-producing substance containing dipeptides and tripeptides may be of animal or fish origin and may have an average molecular weight of 1,000 to 10,000, although it is also preferable to use collagen with an average molecular weight of 1,000 or less.
  • peptides with 2 to 8 repeating peptide bonds or their derivatives Peptides with 2 to 8 repeating amino acids that are useful as cosmetic raw materials are preferred. Oligopeptides containing these are also included. When limiting the type of amino acid, glycine, alanine, proline, hydroxyproline, histidine, threonine, and arginine are preferred.
  • the effects of peptides useful as cosmetics include anti-wrinkle, anti-aging of the skin such as collagen production, activation of skin cells, etc. Specific examples of compounds, shown by their display names, are as shown in FIG.
  • a skin treatment device designed to be used on a user's skin to which any collagen-producing substance containing dipeptides and tripeptides has been applied, and capable of applying an alternating current stimulus of 1.5 kHz or less to the user's skin.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention améliore efficacement un effet d'embellissement sur la peau d'un utilisateur, telle que l'amélioration de la fermeté ou la réduction des rides.　Ce dispositif de traitement de la peau est destiné à être utilisé sur la peau d'un utilisateur sur lequel est appliquée une substance productrice de collagène discrétionnaire contenant des dipeptides et des tripeptides. Le dispositif permet d'appliquer une stimulation de courant alternatif de 1,5 kHz ou moins à la peau de l'utilisateur.
PCT/JP2024/020684 2023-06-08 2024-06-06 Dispositif de traitement de la peau, procédé d'embellissement et procédé de traitement Pending WO2024253157A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202480001352.0A CN119486780A (zh) 2023-06-08 2024-06-06 肌肤处理装置、美容方法以及处理方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2023094968 2023-06-08
JP2023-094968 2023-06-08
JP2023-136663 2023-08-24
JP2023136663 2023-08-24

Publications (1)

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WO2024253157A1 true WO2024253157A1 (fr) 2024-12-12

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CN (1) CN119486780A (fr)
WO (1) WO2024253157A1 (fr)

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004504073A (ja) * 2000-02-18 2004-02-12 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション 交流を用いて薬剤を送達する方法
JP2009095416A (ja) * 2007-10-15 2009-05-07 Ya Man Ltd 美顔器
JP2009178593A (ja) * 2002-11-30 2009-08-13 Cardiac Pacemakers Inc 生体組織の細胞治療と電気治療の方法と装置
US20090221985A1 (en) * 2005-10-19 2009-09-03 Shmuel Bukshpan System for iontophoretic transdermal delivery of polymeric agents and methods of use thereof
CN101785852A (zh) * 2010-01-21 2010-07-28 孙杰 一种真皮层微量介入美容抗衰除皱制剂与方法
JP2012517324A (ja) * 2009-02-12 2012-08-02 パーフュジア メディカル インコーポレーテッド 患者の循環系の循環を操作するための装置及び方法
JP2013135851A (ja) * 2004-10-11 2013-07-11 Sonovia Holdings Llc 皮膚状態を処置するための装置
WO2016194760A1 (fr) * 2015-05-29 2016-12-08 ロート製薬株式会社 Procédé cosmétique et agent topique dermatologique pour utilisation dans celui-ci, agent conférant la migration, et procédé de criblage de composants pour utilisation dans un procédé cosmétique pour améliorer l'état de la peau
US20170326347A1 (en) * 2016-05-12 2017-11-16 EP Technologies LLC Methods and systems for trans-tissue substance delivery using plasmaporation
US20170333705A1 (en) * 2016-05-23 2017-11-23 Btl Holdings Limited Systems and methods for tissue treatment
US20180001102A1 (en) * 2015-03-13 2018-01-04 Optibio Limited Pulsed electromagnetic field treatment
US20180207087A1 (en) * 2017-01-25 2018-07-26 Youna Son Kit and aesthetic system for prevention of skin aging
WO2019185168A1 (fr) * 2018-03-30 2019-10-03 L'oreal Électroporation d'acide hyaluronique et chauffage
US20200254241A1 (en) * 2017-09-20 2020-08-13 L'oreal Electrical method of delivering hyaluronic acid through the skin
JP2020156559A (ja) * 2019-03-25 2020-10-01 ヤーマン株式会社 美容器、及びその制御方法
JP2020534054A (ja) * 2017-09-18 2020-11-26 インキューブ ラブズ， エルエルシー 化粧剤の経皮送達のためのイオン導入システム、キットおよび方法
US20210370082A1 (en) * 2020-05-13 2021-12-02 Cynosure, Llc System and method for skin rejuvenation using impedance monitoring

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004504073A (ja) * 2000-02-18 2004-02-12 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション 交流を用いて薬剤を送達する方法
JP2009178593A (ja) * 2002-11-30 2009-08-13 Cardiac Pacemakers Inc 生体組織の細胞治療と電気治療の方法と装置
JP2013135851A (ja) * 2004-10-11 2013-07-11 Sonovia Holdings Llc 皮膚状態を処置するための装置
US20090221985A1 (en) * 2005-10-19 2009-09-03 Shmuel Bukshpan System for iontophoretic transdermal delivery of polymeric agents and methods of use thereof
JP2009095416A (ja) * 2007-10-15 2009-05-07 Ya Man Ltd 美顔器
JP2012517324A (ja) * 2009-02-12 2012-08-02 パーフュジア メディカル インコーポレーテッド 患者の循環系の循環を操作するための装置及び方法
CN101785852A (zh) * 2010-01-21 2010-07-28 孙杰 一种真皮层微量介入美容抗衰除皱制剂与方法
US20180001102A1 (en) * 2015-03-13 2018-01-04 Optibio Limited Pulsed electromagnetic field treatment
WO2016194760A1 (fr) * 2015-05-29 2016-12-08 ロート製薬株式会社 Procédé cosmétique et agent topique dermatologique pour utilisation dans celui-ci, agent conférant la migration, et procédé de criblage de composants pour utilisation dans un procédé cosmétique pour améliorer l'état de la peau
US20170326347A1 (en) * 2016-05-12 2017-11-16 EP Technologies LLC Methods and systems for trans-tissue substance delivery using plasmaporation
US20170333705A1 (en) * 2016-05-23 2017-11-23 Btl Holdings Limited Systems and methods for tissue treatment
US20180207087A1 (en) * 2017-01-25 2018-07-26 Youna Son Kit and aesthetic system for prevention of skin aging
JP2020534054A (ja) * 2017-09-18 2020-11-26 インキューブ ラブズ， エルエルシー 化粧剤の経皮送達のためのイオン導入システム、キットおよび方法
US20200254241A1 (en) * 2017-09-20 2020-08-13 L'oreal Electrical method of delivering hyaluronic acid through the skin
WO2019185168A1 (fr) * 2018-03-30 2019-10-03 L'oreal Électroporation d'acide hyaluronique et chauffage
JP2020156559A (ja) * 2019-03-25 2020-10-01 ヤーマン株式会社 美容器、及びその制御方法
US20210370082A1 (en) * 2020-05-13 2021-12-02 Cynosure, Llc System and method for skin rejuvenation using impedance monitoring

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