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WO2024249929A3 - Composés, compositions et procédés - Google Patents

Composés, compositions et procédés Download PDF

Info

Publication number
WO2024249929A3
WO2024249929A3 PCT/US2024/032100 US2024032100W WO2024249929A3 WO 2024249929 A3 WO2024249929 A3 WO 2024249929A3 US 2024032100 W US2024032100 W US 2024032100W WO 2024249929 A3 WO2024249929 A3 WO 2024249929A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
compounds
nlrp3
stereoisomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/032100
Other languages
English (en)
Other versions
WO2024249929A2 (fr
Inventor
Alex L. BAGDASARIAN
II Robert A. CRAIG
Javier De Vicente Fidalgo
Brian M. Fox
Benjamin J. HUFFMAN
Katrina W. Lexa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tenvie Therapeutics Inc
Original Assignee
Nico Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nico Therapeutics Inc filed Critical Nico Therapeutics Inc
Publication of WO2024249929A2 publication Critical patent/WO2024249929A2/fr
Publication of WO2024249929A3 publication Critical patent/WO2024249929A3/fr
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente divulgation concerne de manière générale des modulateurs à petites molécules de NLRP3 (NLR Family Pyrin Domain Containing 3), ou un sel pharmaceutiquement acceptable, un analogue enrichi isotopiquement, un stéréoisomère, un mélange de stéréoisomères, ou un promédicament de ceux-ci, des procédés de fabrication et des intermédiaires de ceux-ci, et des procédés d'utilisation de ceux-ci.
PCT/US2024/032100 2023-06-01 2024-05-31 Composés, compositions et procédés Pending WO2024249929A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363505697P 2023-06-01 2023-06-01
US63/505,697 2023-06-01

Publications (2)

Publication Number Publication Date
WO2024249929A2 WO2024249929A2 (fr) 2024-12-05
WO2024249929A3 true WO2024249929A3 (fr) 2025-05-01

Family

ID=93658566

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/032100 Pending WO2024249929A2 (fr) 2023-06-01 2024-05-31 Composés, compositions et procédés

Country Status (1)

Country Link
WO (1) WO2024249929A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025153532A1 (fr) 2024-01-16 2025-07-24 NodThera Limited Polythérapies faisant intervenir des inhibiteurs de nlrp3 et des agonistes de glp-1

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190106436A1 (en) * 2017-10-09 2019-04-11 GiraFpharma LLC Heterocyclic compounds and uses thereof
US10787462B2 (en) * 2015-10-23 2020-09-29 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2022109268A1 (fr) * 2020-11-20 2022-05-27 Denali Therapeutics Inc. Composés, compositions et procédés

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10787462B2 (en) * 2015-10-23 2020-09-29 Takeda Pharmaceutical Company Limited Heterocyclic compound
US20190106436A1 (en) * 2017-10-09 2019-04-11 GiraFpharma LLC Heterocyclic compounds and uses thereof
WO2022109268A1 (fr) * 2020-11-20 2022-05-27 Denali Therapeutics Inc. Composés, compositions et procédés

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE PUBCHEM COMPOUND 20 October 2014 (2014-10-20), XP093312052, Database accession no. 82274917 *
DATABASE PUBCHEM COMPOUND 23 June 2022 (2022-06-23), XP093312053, Database accession no. 163371447 *
DATABASE PUBCHEM COMPOUND 9 February 2007 (2007-02-09), XP093312057, Database accession no. 14713901 *

Also Published As

Publication number Publication date
WO2024249929A2 (fr) 2024-12-05

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