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WO2024249901A3 - Compounds, compositions, and methods - Google Patents

Compounds, compositions, and methods Download PDF

Info

Publication number
WO2024249901A3
WO2024249901A3 PCT/US2024/032057 US2024032057W WO2024249901A3 WO 2024249901 A3 WO2024249901 A3 WO 2024249901A3 US 2024032057 W US2024032057 W US 2024032057W WO 2024249901 A3 WO2024249901 A3 WO 2024249901A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
compounds
stereoisomer
stereoisomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/032057
Other languages
French (fr)
Other versions
WO2024249901A2 (en
Inventor
II Robert A. CRAIG
Javier De Vicente Fidalgo
Benjamin J. HUFFMAN
Katrina W. Lexa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tenvie Therapeutics Inc
Original Assignee
Nico Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nico Therapeutics Inc filed Critical Nico Therapeutics Inc
Publication of WO2024249901A2 publication Critical patent/WO2024249901A2/en
Publication of WO2024249901A3 publication Critical patent/WO2024249901A3/en
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3, or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
PCT/US2024/032057 2023-06-01 2024-05-31 Compounds, compositions, and methods Pending WO2024249901A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363505694P 2023-06-01 2023-06-01
US63/505,694 2023-06-01

Publications (2)

Publication Number Publication Date
WO2024249901A2 WO2024249901A2 (en) 2024-12-05
WO2024249901A3 true WO2024249901A3 (en) 2025-05-22

Family

ID=93658551

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/032057 Pending WO2024249901A2 (en) 2023-06-01 2024-05-31 Compounds, compositions, and methods

Country Status (1)

Country Link
WO (1) WO2024249901A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025153532A1 (en) 2024-01-16 2025-07-24 NodThera Limited Nlrp3 inhibitors and glp-1 agonists combination therapies

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006037481A1 (en) * 2004-09-30 2006-04-13 F.Hoffmann-La Roche Ag Benzoxazine and quinoxaline derivatives and uses
US20100204207A1 (en) * 2004-06-24 2010-08-12 Xinchao Chen Compounds and Methods for Treating Dyslipidemia
WO2019173804A1 (en) * 2018-03-09 2019-09-12 Pharmablock Sciences (Nanjing), Inc. Inhibitors of protein arginine methyltransferase 5 (prmt5), pharmaceutical products thereof, and methods thereof
US10787462B2 (en) * 2015-10-23 2020-09-29 Takeda Pharmaceutical Company Limited Heterocyclic compound

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100204207A1 (en) * 2004-06-24 2010-08-12 Xinchao Chen Compounds and Methods for Treating Dyslipidemia
WO2006037481A1 (en) * 2004-09-30 2006-04-13 F.Hoffmann-La Roche Ag Benzoxazine and quinoxaline derivatives and uses
US10787462B2 (en) * 2015-10-23 2020-09-29 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2019173804A1 (en) * 2018-03-09 2019-09-12 Pharmablock Sciences (Nanjing), Inc. Inhibitors of protein arginine methyltransferase 5 (prmt5), pharmaceutical products thereof, and methods thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE Pubchem 13 January 2016 (2016-01-13), ANONYMOUS: "N-methyl-2-(1-oxo-4,5-dihydro-3H-2-benzazepin-2-yl)acetamide", XP009563930, Database accession no. 104526891 *
DATABASE Pubchem 2 February 2015 (2015-02-02), XP009563929, Database accession no. 86693066 *

Also Published As

Publication number Publication date
WO2024249901A2 (en) 2024-12-05

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