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WO2024249843A3 - Guanfacine for fatigue disorders - Google Patents

Guanfacine for fatigue disorders Download PDF

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Publication number
WO2024249843A3
WO2024249843A3 PCT/US2024/031978 US2024031978W WO2024249843A3 WO 2024249843 A3 WO2024249843 A3 WO 2024249843A3 US 2024031978 W US2024031978 W US 2024031978W WO 2024249843 A3 WO2024249843 A3 WO 2024249843A3
Authority
WO
WIPO (PCT)
Prior art keywords
guanfacine
subject
fatigue
fatigue disorders
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/031978
Other languages
French (fr)
Other versions
WO2024249843A2 (en
Inventor
Jill M. Pulley
Rebecca N. JEROME
Jana K. SHIREY-RICE
Italo Biaggioni
Luis E. OKAMOTO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
Original Assignee
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanderbilt University filed Critical Vanderbilt University
Publication of WO2024249843A2 publication Critical patent/WO2024249843A2/en
Publication of WO2024249843A3 publication Critical patent/WO2024249843A3/en
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed herein are methods for treating a fatigue disorder in a subject in need thereof. The method may include administering to the subject by a therapeutically effective amount of a composition comprising an alpha-2 adrenergic agonist, such as guanfacine. Also disclosed herein are methods of diagnosing a fatigue disorder in a subject.
PCT/US2024/031978 2023-05-31 2024-05-31 Guanfacine for fatigue disorders Pending WO2024249843A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363470112P 2023-05-31 2023-05-31
US63/470,112 2023-05-31

Publications (2)

Publication Number Publication Date
WO2024249843A2 WO2024249843A2 (en) 2024-12-05
WO2024249843A3 true WO2024249843A3 (en) 2025-05-01

Family

ID=93658636

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/031978 Pending WO2024249843A2 (en) 2023-05-31 2024-05-31 Guanfacine for fatigue disorders

Country Status (1)

Country Link
WO (1) WO2024249843A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020176807A1 (en) 2019-02-27 2020-09-03 Vanderbilt University Methods of treating trigeminal nerve pain

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001048246A1 (en) * 1999-12-29 2001-07-05 Vanderbilt University Genetic mutation underlying orthostatic intolerance and diagnostic and therapeutic methods relating thereto
US20080021074A1 (en) * 2006-06-29 2008-01-24 Questcor Pharmaceuticals, Inc. Pharmaceutical Compositions and Related Methods of Treatment
WO2009155139A1 (en) * 2008-06-20 2009-12-23 Afecta Pharmaceuticals, Inc. Use of isoindoles for the treatment of neurobehavioral disorders
WO2019136224A1 (en) * 2018-01-05 2019-07-11 Shire Human Genetic Therapies, Inc. Amphetamine-guanfacine combinations for treatment of neuropsychiatric disorders
US20190282583A1 (en) * 2015-06-22 2019-09-19 Embera Neurotherapeutics, Inc. Compositions and methods for the treatment of substance use disorders, addiction, and psychiatric disorders

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001048246A1 (en) * 1999-12-29 2001-07-05 Vanderbilt University Genetic mutation underlying orthostatic intolerance and diagnostic and therapeutic methods relating thereto
US20080021074A1 (en) * 2006-06-29 2008-01-24 Questcor Pharmaceuticals, Inc. Pharmaceutical Compositions and Related Methods of Treatment
WO2009155139A1 (en) * 2008-06-20 2009-12-23 Afecta Pharmaceuticals, Inc. Use of isoindoles for the treatment of neurobehavioral disorders
US20190282583A1 (en) * 2015-06-22 2019-09-19 Embera Neurotherapeutics, Inc. Compositions and methods for the treatment of substance use disorders, addiction, and psychiatric disorders
WO2019136224A1 (en) * 2018-01-05 2019-07-11 Shire Human Genetic Therapies, Inc. Amphetamine-guanfacine combinations for treatment of neuropsychiatric disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
STÖBER GERALD, NÖTHEN MARKUS M., PÖRZGEN PETER, BRÜSS MICHAEL, BÖNISCH HEINZ, KNAPP MICHAEL, BECKMANN HELMUT, PROPPING PETER: "Systematic search for variation in the human norepinephrine transporter gene: Identification of five naturally occurring missense mutations and study of association with major psychiatric disorders", AMERICAN JOURNAL OF MEDICAL GENETICS, WILEY, NEW YORK,NY, US, vol. 67, no. 6, 22 November 1996 (1996-11-22), US , pages 523 - 532, XP093312755, ISSN: 0148-7299, DOI: 10.1002/(SICI)1096-8628(19961122)67:6<523::AID-AJMG3>3.0.CO;2-I *

Also Published As

Publication number Publication date
WO2024249843A2 (en) 2024-12-05

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