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WO2024241256A1 - Appareil pour la prevention de la recurrence tumorale - Google Patents

Appareil pour la prevention de la recurrence tumorale Download PDF

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Publication number
WO2024241256A1
WO2024241256A1 PCT/IB2024/055010 IB2024055010W WO2024241256A1 WO 2024241256 A1 WO2024241256 A1 WO 2024241256A1 IB 2024055010 W IB2024055010 W IB 2024055010W WO 2024241256 A1 WO2024241256 A1 WO 2024241256A1
Authority
WO
WIPO (PCT)
Prior art keywords
actuator
stimulation
tissue
support element
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/IB2024/055010
Other languages
English (en)
Inventor
Domenico PRATTICHIZZO
Serena ZACCHIGNA
Alberto Villani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CENTRO CARDIOLOGICO MONZINO SpA
International Centre for Genetic Engineering and Biotechnology
Universita degli Studi di Siena
Original Assignee
CENTRO CARDIOLOGICO MONZINO SpA
International Centre for Genetic Engineering and Biotechnology
Universita degli Studi di Siena
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CENTRO CARDIOLOGICO MONZINO SpA, International Centre for Genetic Engineering and Biotechnology, Universita degli Studi di Siena filed Critical CENTRO CARDIOLOGICO MONZINO SpA
Publication of WO2024241256A1 publication Critical patent/WO2024241256A1/fr
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H11/00—Belts, strips or combs for massage purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
    • A61H23/006—Percussion or tapping massage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
    • A61H23/04—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with hydraulic or pneumatic drive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H9/00—Pneumatic or hydraulic massage
    • A61H9/0007—Pulsating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H9/00—Pneumatic or hydraulic massage
    • A61H9/005—Pneumatic massage
    • A61H9/0078—Pneumatic massage with intermittent or alternately inflated bladders or cuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H11/00—Belts, strips or combs for massage purposes
    • A61H2011/005—Belts, strips or combs for massage purposes with belt or strap expanding and contracting around an encircled body part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/12—Driving means
    • A61H2201/1207—Driving means with electric or magnetic drive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/12—Driving means
    • A61H2201/1238—Driving means with hydraulic or pneumatic drive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/16—Physical interface with patient
    • A61H2201/1602—Physical interface with patient kind of interface, e.g. head rest, knee support or lumbar support
    • A61H2201/165—Wearable interfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/50—Control means thereof
    • A61H2201/5058—Sensors or detectors
    • A61H2201/5061—Force sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/50—Control means thereof
    • A61H2201/5058—Sensors or detectors
    • A61H2201/5071—Pressure sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/50—Control means thereof
    • A61H2201/5058—Sensors or detectors
    • A61H2201/5082—Temperature sensors

Definitions

  • the present invention relates to a wearable apparatus for the treatment of cancer cells through a mechanical stimulation of a patient ' s surface tissue , in particular the skin, the subcutis or the mammary gland .
  • Cancer is the second leading cause of death globally, placing a huge physical , emotional and financial burden on patients , their families , the community and health systems .
  • the control and prevention of local cancer recurrence is one of the greatest needs not yet fully met .
  • the occurrence of a recurrence usually precedes metastatic dissemination and has a negative impact on both long-term survival and the quality of li fe of patients .
  • the therapies currently used for the treatment of cancer and the prevention of recurrence have signi ficant side ef fects and are mainly based on the systemic treatment of metastatic disease , a point in which a long-term cure is rarely possible .
  • the main ef fective treatment for cancer has been chemotherapy .
  • tumour non-proliferation in the human and mouse heart, medical-biological investigation has oriented the search for the inhibitory causes of the tumour towards biological-mechanical interaction phenomena.
  • the progression of cancer is known to be influenced by mechanical stimuli. Changes in tissue stiffness and density are important stimuli of tumour progression and are often exploited in cancer diagnosis by both palpation and imaging. However, if the biological-mechanic interaction has revealed how mechanical properties (stiffness, elasticity) affect the growth of cancer cells, little is still known about the actual role of mechanical stimuli (pressure, tension) .
  • the mammalian heart is rarely affected by cancer, perhaps due to the same mechanisms which stop cardiac regeneration.
  • Primary myocardial tumours are extremely rare, with a prevalence of approximately 0.0017%.
  • Heart metastases often affect the pericardium or large vessels, and not the myocardium.
  • cancer cells implanted ectopically in the heart form small tumours, which are not vascularized, indicating that the cardiac environment hinders the growth of both endothelial and cancer cells.
  • the mammalian heart loses its regenerative capacity quite quickly after birth.
  • CMS cardiomyocytes
  • cardiac endothelial cells after birth .
  • mechanical stimuli are emerging as key players .
  • the mechanical discharge of the heart as occurs in patients implanted with a Left Ventricular Assisted Device (LVAD) .
  • LVAD Left Ventricular Assisted Device
  • EP 3 312 506 Al discloses a device for the treatment of tumours in the gastrointestinal tract through a mechanical stimulation of tissues and WO 2020/223242 Al discloses a method for treating cancer cells through external mechanical stimulation (pneumatic or hydraulic ) at a speci fic frequency and intensity such as to induce cell death ( apoptosis ) .
  • external mechanical stimulation pneumatic or hydraulic
  • these solutions involve treatments inside the human body and therefore require surgical intervention on the patient .
  • bulky, expensive equipment is often necessary and can only be used by speciali zed personnel . In this case , the patient is obliged to go to special hospital facilities to receive the treatment .
  • an obj ect of the present invention is to provide an apparatus for the treatment of cancer cells which partially or completely overcomes the drawbacks of the prior art .
  • a wearable apparatus for the treatment of cancer cells through a mechanical stimulation of a patient ' s surface tissue , in particular the skin, the subcutis or the mammary gland .
  • the apparatus comprises a support element applicable on the tissue of said patient and a stimulation and control device connected to the support element , in which said stimulation and control device comprises : at least one actuator for trans ferring the mechanical stimulation at at least one stimulation point ;
  • At least one sensor for detecting a physical property at the tissue of the patient to be treated and for generating a corresponding sensor signal ;
  • control unit connected to the actuator and to the sensor for regulating the activity of said actuator by means of a control signal as a function of at least said sensor signal , wherein the mechanical stimulation is trans ferred from the actuator to the stimulation point so as to determine a deformation of the tissue to be treated, in particular a contraction and a release of said tissue , according to a cyclical trend .
  • the deformation of the stimulation points can be comparable to a cyclical function which alternates a compression and a release of the treated tissue .
  • the tissue represents a dynamic environment highly unfavourable to tumour proli feration by mechanically-activated biological mechanisms .
  • the cyclical trend can be comparable to a cardiac cycle , i . e .
  • the forces and deformations of the mechanical stimulation by the device can be comparable to the forces and deformations to which the heart is subj ected .
  • other cyclical trends di f ferent from the cardiac one , can be advantageously used to achieve the same purpose .
  • tissue to be treated is mechanically stimulated and not through an electric discharge as occurs , for example , with the muscle stimulators known in the literature .
  • Fig . 1 shows a schematic representation of an apparatus for the treatment of cancer cells according to an example .
  • Fig . 2A-B show two possible embodiments of the apparatus in which the support element is a band (A) or an item of clothing (B ) .
  • Fig . 3 schematically shows the types of stimulation of the apparatus according to the example of figure 2A.
  • Fig . 4 shows a flow diagram of the closed-loop control according to an example .
  • Figure 1 shows an apparatus 1 for the treatment of cancer cells 10 through a mechanical stimulation .
  • the apparatus 1 is capable of reproducing - or simulating - mechanical stimuli locally, such as those which characteri ze a cardiac cycle , on a skin or sub-cutaneous tissue for the prevention of tumour recurrence which are reachable by tactile stimulation, such as melanomas , breast tumours , etc .
  • the apparatus 1 is wearable and comprises a support element 2 which can be applied to the patient ' s tissue .
  • the support element 2 can be made of textile material in the form of a band or an item of clothing (bra, tank top, t-shirt , stocking, etc . ) .
  • the support element 2 can of course be made of various materials , such as for example natural fibre or synthetic fibre materials .
  • the support element 2 can be made of elasticised material to facilitate contact with the skin tissue of the patient .
  • the support element 2 can also be totally or partially made of plastic or silicone .
  • the apparatus 1 further comprises a stimulation and control device 3 .
  • This device 3 is connected to the support element 2 so that the stimulation generated by the device 3 can possibly be trans ferred to the support element 2 .
  • the stimulation and control device 3 can be removably connected to the support element 2 .
  • the stimulation and control device 3 can be integrated in the support element 2 .
  • the stimulation and control device 3 comprises one or more sensors 6 for detecting a physical property at the patient ' s tissue .
  • the sensor 6 serves to detect at least one physical property comprised between a pressure , a temperature , a hardness , a local deformation, and/or an optical property .
  • the sensor 6 can be a force sensor for measuring the force exerted on a region of the tissue - i . e . , the pressure .
  • the device 3 can however comprise a di f ferent sensor 6 , for example a sensor for detecting the temperature or other parameters for monitoring the state of the patient ' s tissue and in particular of the cancer cells 10 .
  • the sensor 6 Based on the type of sensor present , the sensor 6 generates a corresponding sensor signal comprising information related to the measured physical property .
  • the sensor 6 can for example be a durometer for measuring the hardness of the tissue , an optical sensor for measuring the optical properties of the tissue or a strain gauge for measuring the local strain of the tissue .
  • the stimulation and control device 3 further comprises one or more actuators 4 .
  • the actuator 4 serves to trans fer the mechanical stimulation at at least one stimulation point 5 .
  • the stimulation and control device 3 further comprises a control unit 7 .
  • This is connected to the sensor 6 to receive the sensor signal and is connected to the actuator 4 to regulate the activity of the actuator 4 itsel f by means of a control signal .
  • the control signal is generated as a function of the sensor signal .
  • the control signal can be generated as a function of other information or data defined in advance and present in the control unit 7 .
  • the various elements of the device 1 can be powered by a battery 9 .
  • a battery 9 is connected at least to the control unit 7 but can also be additionally connected to the sensor 6 and the actuator 4 .
  • the battery 9 is a rechargeable battery . It should be noted that the device 1 can be powered according to alternative modes which do not necessarily include a battery 9 , for example by exploiting solar and/or kinetic energy generated by the patient .
  • the mechanical stimulation trans ferred from the actuator 4 to the stimulation point 5 causes a deformation of the tissue to be treated such as to simulate a cardiac cycle .
  • the tissue deformation can be represented by a contraction and release of the tissue itsel f similar to the contraction and release of cardiac tissue during cardiac activity .
  • the control unit 7 is programmed and thus configured so as to send a control signal to the actuator 4 and allow the actuator 4 to reproduce on the diseased tissue ( at the stimulation point 5 ) a stimulation analogous to the heartbeat , thus emulating, locally, the force and pressure to which the walls of the heart are subj ected and their deformation .
  • the mechanical stimulation trans ferred from the actuator 4 to the stimulation point 5 causes on the stimulation point 5 , and thus consequently on the tissue to be treated, a frequency greater than or equal to 0 . 05 Hz , in particular a frequency greater than or equal to 1 Hz , more in particular a frequency comprised between 1 Hz ( 60 beats per minute , bpm) and 2 Hz ( 120 bpm) , emulating the heart rate of a healthy heart in conditions of rest and under stress .
  • the frequency is not varied randomly but according to a certain cycle , i . e . , the cardiac cycle , as mentioned above .
  • the wearable apparatus 1 disclosed herein can transfer a mechanical stimulation at the stimulation point 5, and thus consequently on the tissue to be treated, having a pressure varying between a stimulation pressure P s and a relaxation pressure P r , according to the parameters disclosed above.
  • the wearable apparatus 1 described herein can transfer a mechanical stimulation with a frequency according to the parameters described above. By combining these frequency and pressure values it is possible to more effectively simulate the cardiac cycle.
  • the actuator 4 is configured to exert a temporally asymmetrical stimulation profile.
  • the mechanical stimulation process exerted by the actuator 4 is such as to have different times for the ascending (e.g., contraction) and descending (e.g., relaxation) phases of the cycle.
  • the time taken to go from an initial state to a final state is di f ferent than the time taken to return from the final state to the initial state .
  • At least one actuator 4 is a mechanical or electromechanical actuator, in particular a linear actuator or a servomotor .
  • tendons , gears and pulleys can transmit the motion activated by motors and servomotors to the stimulation point 5 and thus to the patient ' s tissue, for example by acting directly on the tissue itsel f or indirectly by acting on the support element 2 .
  • the actuator 4 and/or the support element 2 can be made of materials having a hardness comprised between 10 and 30 Shore 00 to ef fectively emulate at the stimulation point 5 the volumetric deformation of the cardiac cycle during the systole and diastole phases .
  • di f ferent types of actuators 4 capable of imparting a mechanical stimulation at the stimulation point 5 can also be used .
  • Figures 2A and 2B show two types of wearable apparatus 1 for the treatment of cancer cells 10 .
  • the support element 2 is a textile or silicone band .
  • the apparatus 1 can thus be worn on a patient ' s arm at a melanoma 10 .
  • the double arrows indicate the action of the actuator 4 (not visible in the figure ) on the band-shaped support element 2 .
  • the action of the actuator 4 can cause a constriction or a release of the band so that at the stimulation point 5 or at the cancer cells 10 , a deformation of the support 2 and thus of the skin tissue occurs .
  • the action of the actuator 4 is controlled by the control unit 7 so that the deformation varies over time as in the case of a cardiac contraction, according to for example the aforementioned parameters of pressure , frequency and/or volumetric variation .
  • the support element 2 is an undergarment , e . g . , a bra .
  • the apparatus 1 can thus be worn and the stimulation and control device 3 is located at the cancer cells 10 , for example of the left breast .
  • the stimulation and control device 3 is removable from the support element 2 and can be conveniently placed on another region of the support element 2 , for example at the right breast or another area of the left breast .
  • the stimulation point 5 is the active contact point between the apparatus 1 and the diseased tissue to be subj ected to mechanical stimulation .
  • at least one stimulation point 5 is integral with the support element 2 .
  • the stimulation point 5 can be a portion of the support element 2 .
  • the action of the actuator 4 is trans ferred to the support element 2 so that the stimulation point 5 is positioned on a region of the support element 2 in contact with the patient ' s tissue .
  • the transmission of the mechanical stimulation from the actuator 4 to the stimulation point 5 occurs indirectly .
  • two or more points of the support element 2 can be pulled in opposite directions so as to cause a pressure at a region of the support element 2 - i.e., the stimulation point 5 - by means of, for example, a constriction of the support element 2 (e.g., constriction of the band around the patient ' s arm) .
  • a constriction of the support element 2 e.g., constriction of the band around the patient ' s arm
  • At least one stimulation point 5 can be integral with the stimulation and control device 3.
  • the stimulation point 5 can be a part of the actuator 4.
  • the action of the actuator 4 is transferred directly to the stimulation point 5 which is in contact with the patient's tissue.
  • the apparatus 1 can further comprise a thrust body 8 connected to the actuator 4, in which said thrust body 8 is rigid or deformable (shown in figure 1 as a dashed element) .
  • the thrust body is configured to impart a local force and pressure by expanding or extruding itself.
  • the thrust body 8 can be for example a pin or a spherical body representing the transmission system of the mechanical stimulation.
  • the thrust body can be integrated with or separate from the actuator 4.
  • three different modes of mechanical stimulation of cancer cells 10 are shown considering the configuration of the apparatus 1 of figure 2A, i.e., of a band applied around the arm of a patient.
  • the mechanical stimulation occurs by global contraction of the support element 2.
  • a stimulation occurs by cyclical contraction of the support 2 which compresses and releases the tissue to be treated in a cyclical, widespread and global manner.
  • the constriction of the band generates a compression of the forearm, site of a melanoma, for example.
  • the controlled closed-loop application occurs below the stimulation device 3 as an element capable of measuring the mechanical state of the tissue.
  • the mechanical stimulation instead occurs by local expansion of the support element 2 at the stimulation point 5.
  • a thrust body 8 can be pressed by the action of the actuator 4 towards the stimulation point 5.
  • a pneumatic device with a thrust body 8 can locally exert a pressure on the tissue to be treated by expansion of a deformable membrane. This is represented by the arrows exiting from the thrust body 8.
  • the expansion of the thrust body 8 also spreads the stimulation to the tissues in contact with the support 2.
  • the control circuit closes exclusively around the stimulation device 3 and in detail around the thrust body 8.
  • the mechanical stimulation occurs for a combination of the contraction according to example (i) and the expansion according to example (ii) .
  • the two stimulation methods described above i.e., diffused by means of the support 2 and locally by means of the thrust body 8.
  • the stimulation is exercised by means of the stimulation point 5 (for example a special thrust body or the band itself) which is activated by means of, for example, a motor controlled by the control unit 7 which integrates the information provided by the measurement sensor 6 with an internal programming thereof adapted to emulate the heartbeat.
  • the resulting stimulation is then exerted on the patient's skin through constriction of the band, expansion of the stimulation point, or a combination thereof.
  • the actuator 4, the sensor 6 and the control unit 7 represent a closed-loop control system.
  • the closed-loop control system is configured to carry out the measurement of a first force applied to the patient's tissue by means of the sensor 6, the generation of a control signal by the control unit 7 following at least said measurement, the activation of the actuator 4 by means of said control signal and the application of a second force, different from the first force, on the patient's tissue.
  • the steps of this control process 100 are shown in figure 4.
  • the operation of the stimulation and control device 3 consists of a continuous cycle of force measurements, calculation of the force to be applied and application thereof according to the following model.
  • the sensor 6 measures the force applied on the skin (S101) .
  • the control unit 7 - on the basis of the information provided by the sensor 6 together with the force reference already known in its programming - generates a control signal (S102) .
  • the control signal activates an actuator 4 (S103) .
  • the actuator 4 generates a deformation and/or a force which is transferred to the stimulation point 5 by means of a transmission system (S104) .
  • the closed-loop control system is a closed measurement-control-actuation loop around the patient ' s skin .
  • the design of the aforesaid devices as to materials, transmission and implementation meets the three paradigms of wearable robotics, namely i) safety, ii) convenience and iii) ease of use.

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rehabilitation Therapy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Percussion Or Vibration Massage (AREA)

Abstract

L'invention concerne un appareil portable (1) pour le traitement de cellules cancéreuses par stimulation mécanique d'un tissu de surface d'un patient, en particulier la peau, la sous-cutis ou la glande mammaire, l'appareil (1) comprenant un élément de support (2) applicable sur le tissu dudit patient, et un dispositif de stimulation et de commande (3) relié à l'élément de support (2), ledit dispositif de stimulation et de commande (3) comprenant au moins un actionneur (4) pour transférer la stimulation mécanique au niveau d'au moins un point de stimulation (5), au moins un capteur (6) pour détecter une propriété physique au niveau du tissu du patient à traiter et pour générer un signal de capteur correspondant, et une unité de commande (7) connectée à l'actionneur (4) et au capteur (6) pour réguler l'activité dudit actionneur (4) au moyen d'un signal de commande en fonction dudit au moins un signal de capteur, la stimulation mécanique étant transférée de l'actionneur (4) au point de stimulation (5) de façon à provoquer une déformation du tissu à traiter, en particulier une contraction et une libération dudit tissu, selon une tendance cyclique.
PCT/IB2024/055010 2023-05-25 2024-05-23 Appareil pour la prevention de la recurrence tumorale Pending WO2024241256A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102023000010590 2023-05-25
IT102023000010590A IT202300010590A1 (it) 2023-05-25 2023-05-25 Apparato per la prevenzione delle recidive tumorali

Publications (1)

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WO2024241256A1 true WO2024241256A1 (fr) 2024-11-28

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WO (1) WO2024241256A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010093753A1 (fr) * 2009-02-12 2010-08-19 Perfuzia Medical, Inc. Dispositifs et procédés pour la manipulation de la circulation dans le système circulatoire d'un patient
WO2018039458A1 (fr) * 2016-08-25 2018-03-01 Cala Health, Inc. Systèmes et méthodes pour traiter un dysfonctionnement cardiaque par stimulation du nerf périphérique
US20180185238A1 (en) * 2015-06-28 2018-07-05 Yaron Ilan Devices for gastrointestinal stimulation and uses thereof
US20220125666A1 (en) * 2020-10-23 2022-04-28 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Devices and methods for lymphedema treatment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016012639B4 (de) 2016-10-24 2018-09-20 Nicola Barthelme Verkettbares, vollvergossenes, flexibles Leuchtdiodenband und Verfahren zu dessen Herstellung
US20220203138A1 (en) 2019-05-01 2022-06-30 Mechanobiologics Llc Systems and Methods for Cancer Treatment

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010093753A1 (fr) * 2009-02-12 2010-08-19 Perfuzia Medical, Inc. Dispositifs et procédés pour la manipulation de la circulation dans le système circulatoire d'un patient
US20180185238A1 (en) * 2015-06-28 2018-07-05 Yaron Ilan Devices for gastrointestinal stimulation and uses thereof
WO2018039458A1 (fr) * 2016-08-25 2018-03-01 Cala Health, Inc. Systèmes et méthodes pour traiter un dysfonctionnement cardiaque par stimulation du nerf périphérique
US20220125666A1 (en) * 2020-10-23 2022-04-28 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Devices and methods for lymphedema treatment

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