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WO2024139794A1 - Extrait d'artemisia annua ayant un effet d'inhibition de la protéine trpv1 - Google Patents

Extrait d'artemisia annua ayant un effet d'inhibition de la protéine trpv1 Download PDF

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Publication number
WO2024139794A1
WO2024139794A1 PCT/CN2023/131369 CN2023131369W WO2024139794A1 WO 2024139794 A1 WO2024139794 A1 WO 2024139794A1 CN 2023131369 W CN2023131369 W CN 2023131369W WO 2024139794 A1 WO2024139794 A1 WO 2024139794A1
Authority
WO
WIPO (PCT)
Prior art keywords
artemisia annua
annua extract
extract
skin
trpv1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2023/131369
Other languages
English (en)
Chinese (zh)
Inventor
陈默
殷庆飞
孙懿
祝乐
赵亚
陈园园
贾海东
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Jahwa United Co Ltd
Original Assignee
Shanghai Jahwa United Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Jahwa United Co Ltd filed Critical Shanghai Jahwa United Co Ltd
Publication of WO2024139794A1 publication Critical patent/WO2024139794A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the invention relates to the fields of natural drug chemistry and cosmetics, and in particular to an Artemisia annua extract having a TRPV1 protein inhibitory effect.
  • the artemisia annua extract of the present invention can be prepared by microwave extraction.
  • microwave extraction For example, water-assisted microwave extraction can be used for extraction.
  • one or more emollients can be used to act as lubricants through their ability to remain on the surface of the skin or in the stratum corneum to reduce flaking and improve the appearance of the skin.
  • Typical emollients include fatty esters, fatty alcohols, mineral oils, polyether siloxane copolymers, and the like.
  • TRPV1 detection The cells were fixed with 4% paraformaldehyde for 30 minutes, and then immunofluorescence detection of capsaicin receptor (TRPV1) was performed. The cells were photographed and observed under a microscope, and the images were collected and analyzed.
  • the solid solution of the Artemisia annua extract prepared in Example 1 was concentrated to a thick paste, maltodextrin was added, mixed, granulated, and filled into capsules, each containing 0.2 g, and 1000 capsules were prepared.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne une utilisation d'un extrait d'Artemisia annua dans l'inhibition de la protéine TRPV1, l'extrait d'Artemisia annua étant préparé au moyen d'un procédé d'extraction par solvant. L'invention concerne en outre une utilisation de l'extrait d'Artemisia annua dans la préparation d'un produit ayant un effet d'inhibition de la protéine TRPV1, le produit étant un médicament, un aliment fonctionnel ou une préparation externe de peau, et l'extrait d'Artemisia annua étant préparé au moyen d'un procédé d'extraction par solvant.
PCT/CN2023/131369 2022-12-26 2023-11-13 Extrait d'artemisia annua ayant un effet d'inhibition de la protéine trpv1 Ceased WO2024139794A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202211676162.8A CN115844939A (zh) 2022-12-26 2022-12-26 具有trpv1蛋白抑制作用的青蒿提取物
CN202211676162.8 2022-12-26

Publications (1)

Publication Number Publication Date
WO2024139794A1 true WO2024139794A1 (fr) 2024-07-04

Family

ID=85654845

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2023/131369 Ceased WO2024139794A1 (fr) 2022-12-26 2023-11-13 Extrait d'artemisia annua ayant un effet d'inhibition de la protéine trpv1

Country Status (2)

Country Link
CN (1) CN115844939A (fr)
WO (1) WO2024139794A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115844939A (zh) * 2022-12-26 2023-03-28 上海家化联合股份有限公司 具有trpv1蛋白抑制作用的青蒿提取物
CN116211774A (zh) * 2023-04-17 2023-06-06 上海家化联合股份有限公司 I型胶原蛋白产生促进剂

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108478489A (zh) * 2018-05-18 2018-09-04 上海家化联合股份有限公司 青蒿提取物的保湿用途及含青蒿提取物的皮肤组合物
KR101983571B1 (ko) * 2018-11-29 2019-05-29 강원대학교 산학협력단 나트륨 및 칼륨 수용체를 활성화시키는 천연 소재를 이용한 염미제 조성물
CN109939105A (zh) * 2017-12-20 2019-06-28 隐纱化妆品有限公司 青蒿素及其衍生物的用途
CN111925979A (zh) * 2020-08-14 2020-11-13 贵州省人民医院 青蒿素改善玫瑰痤疮炎症用动物和细胞模型的构建方法
CN113855718A (zh) * 2021-09-30 2021-12-31 上海家化联合股份有限公司 青蒿提取物及其应用
CN114786725A (zh) * 2019-09-18 2022-07-22 药妆研究有限责任公司 含有内源性大麻素模拟物和抗炎化合物的组合物、其制备方法及用途
CN115607493A (zh) * 2022-10-19 2023-01-17 广州伽能生物科技有限公司 一种止痒舒缓组合物及其制备方法
CN115844939A (zh) * 2022-12-26 2023-03-28 上海家化联合股份有限公司 具有trpv1蛋白抑制作用的青蒿提取物

Patent Citations (8)

* Cited by examiner, † Cited by third party
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CN109939105A (zh) * 2017-12-20 2019-06-28 隐纱化妆品有限公司 青蒿素及其衍生物的用途
CN108478489A (zh) * 2018-05-18 2018-09-04 上海家化联合股份有限公司 青蒿提取物的保湿用途及含青蒿提取物的皮肤组合物
KR101983571B1 (ko) * 2018-11-29 2019-05-29 강원대학교 산학협력단 나트륨 및 칼륨 수용체를 활성화시키는 천연 소재를 이용한 염미제 조성물
CN114786725A (zh) * 2019-09-18 2022-07-22 药妆研究有限责任公司 含有内源性大麻素模拟物和抗炎化合物的组合物、其制备方法及用途
CN111925979A (zh) * 2020-08-14 2020-11-13 贵州省人民医院 青蒿素改善玫瑰痤疮炎症用动物和细胞模型的构建方法
CN113855718A (zh) * 2021-09-30 2021-12-31 上海家化联合股份有限公司 青蒿提取物及其应用
CN115607493A (zh) * 2022-10-19 2023-01-17 广州伽能生物科技有限公司 一种止痒舒缓组合物及其制备方法
CN115844939A (zh) * 2022-12-26 2023-03-28 上海家化联合股份有限公司 具有trpv1蛋白抑制作用的青蒿提取物

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Title
HERBRECHTER ROBIN, BELTRÁN LEOPOLDO R., ZIEMBA PAUL M., TITT SASCHA, LASHUK KONSTANTIN, GOTTEMEYER ANDRÉ, LEVERMANN JANINA, HOFFMA: "Effect of 158 herbal remedies on human TRPV1 and the two-pore domain potassium channels KCNK2, 3 and 9", JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE, MEDKNOW PUBL., INDIA, vol. 10, no. 5, 1 September 2020 (2020-09-01), INDIA , pages 446 - 453, XP093185696, ISSN: 2225-4110, DOI: 10.1016/j.jtcme.2020.04.005 *
YAN SHIDU, HUANG YUCHAN, XIAO QIAN, SU ZIXIA, XIA LEI, XIE JINLING, ZHANG FAN, DU ZHENGCAI, HOU XIAOTAO, DENG JIAGANG, HAO ERWEI: "Regulation of transient receptor potential channels by traditional Chinese medicines and their active ingredients", FRONTIERS IN PHARMACOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 13, 13 October 2022 (2022-10-13), CH , XP093185697, ISSN: 1663-9812, DOI: 10.3389/fphar.2022.1039412 *

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