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WO2024130577A1 - Système de surveillance en temps réel des signes vitaux d'un animal - Google Patents

Système de surveillance en temps réel des signes vitaux d'un animal Download PDF

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Publication number
WO2024130577A1
WO2024130577A1 PCT/CN2022/140572 CN2022140572W WO2024130577A1 WO 2024130577 A1 WO2024130577 A1 WO 2024130577A1 CN 2022140572 W CN2022140572 W CN 2022140572W WO 2024130577 A1 WO2024130577 A1 WO 2024130577A1
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WIPO (PCT)
Prior art keywords
animal
physiological information
real
time monitoring
acquisition sensor
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Ceased
Application number
PCT/CN2022/140572
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English (en)
Chinese (zh)
Inventor
王琳
张一栏
王烨
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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Priority to PCT/CN2022/140572 priority Critical patent/WO2024130577A1/fr
Publication of WO2024130577A1 publication Critical patent/WO2024130577A1/fr
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition

Definitions

  • the present application relates to the technical field of laboratory animal vital sign monitoring, and in particular to a real-time monitoring system for animal vital signs.
  • the existing small animal wearable fabrics have a relatively simple function, usually used to fix small animals for acupuncture and other operations.
  • Devices for monitoring the physiological information of small animals are generally complex, cannot be worn, and have few measurement parameters.
  • implantable small animal physiological information monitoring technologies There are implantable small animal physiological information monitoring technologies, but they will interfere with the normal physiological information of small animals.
  • fixation clothes for mouse fixation and acupuncture there are similar invention patents such as fixation clothes for mouse fixation and acupuncture.
  • the patent application number 201420853966.5 “Fixation clothes and fixation device for experimental mice” proposes a mouse fixation clothes and fixation device used in medical animal experiments; the patent application number 201320727782.
  • “Mouse abdominal and dorsal acupuncture fixator” proposes a mouse abdominal and dorsal acupuncture fixator that can perform acupuncture on the back and abdomen of mice at the same time;
  • the patent application number 200510019571.0 “Mouse asthma model vital signs monitoring device” realizes the accurate measurement and analysis of the vital signs of mouse asthma model, which is suitable for the basic research on the cause and pathogenesis of asthma.
  • the measurement parameters of these devices are relatively single.
  • Patent application number 201920519555.5 "A monitoring device for detecting the vital signs of mice”, uses millimeter-wave radar and digital signal modules to analyze and process the heart rate and respiratory rate of mice, but the accuracy is not high;
  • Patent application number 202111134089.7 "A laboratory anesthesia information processing system and method based on big data”, collects corresponding data through electrocardiogram acquisition modules, blood pressure acquisition modules, and blood oxygen saturation acquisition modules, and processes anesthesia information by adjusting the concentration of anesthetic drugs.
  • the system device and operation are relatively complicated.
  • the above inventions for in vitro physiological information monitoring of mice have relatively simple measurement parameters and complex systems. At present, there are some small animal vital signs monitoring devices implanted in the body on the market, but they cause great damage to mice and affect normal physiological information parameters.
  • One of the purposes of the present application is to provide a real-time monitoring system for animal vital signs, comprising: a signal acquisition sensor, a wearable fabric and a signal analysis platform, wherein the signal acquisition sensor is used to detect physiological information parameters, the signal acquisition sensor is fixed on the wearable fabric, and the signal analysis platform is used to obtain the physiological information parameters and analyze the physiological information parameters, wherein the physiological information parameters include animal heart rate, respiratory rate, body temperature, blood oxygen saturation and number of exercise steps.
  • the information acquisition sensor is connected to the embedded main control STM32F103C8T6, and receives the physiological information parameters using a Bluetooth gateway through a broadcast protocol, and transmits the physiological information parameters to the signal analysis platform.
  • the signal analysis platform obtains the animal's heart rate, respiratory rate, body temperature, blood oxygen saturation and exercise steps based on the physiological information parameters.
  • the signal acquisition sensor includes a PPG green light module, and the PPG green light module obtains dynamic heart rate parameters according to photoplethysmography.
  • the signal analysis platform performs time domain analysis on the dynamic heart rate parameters to calculate the heart rate value.
  • the signal acquisition sensor includes a PPG red light and infrared light module.
  • the PPG red light and infrared light module obtains the blood oxygen saturation parameter according to the different absorption characteristics of oxygenated hemoglobin HbO2 and hemoglobin Hb contained in the blood to light of different wavelengths, and the signal analysis platform calculates the corresponding ratio according to the blood oxygen saturation parameter to obtain the blood oxygen value.
  • the signal acquisition sensor includes a high thermal conductivity temperature sensor, which can continuously measure the animal's body surface temperature, and the signal analysis platform calculates the body temperature through a built-in algorithm based on the body surface temperature.
  • the signal acquisition sensor includes an accelerometer, using the a x , a y , and a z parameters of the three-axis accelerometer, and the signal analysis platform obtains the signal through median filtering and peak detection.
  • the signal analysis platform obtains the respiratory rate based on the heart rate value.
  • the wearable fabric is made of elastic woven fabric, and a fixed pocket for fixing the signal acquisition sensor is provided at a position of the wearable fabric close to the heart of the animal.
  • the animal vital signs real-time monitoring system comprises: a signal acquisition sensor, a wearable fabric and a signal analysis platform, wherein the signal acquisition sensor is used to detect physiological information parameters, the signal acquisition sensor is fixed on the wearable fabric, and the signal analysis platform is used to obtain the physiological information parameters and analyze the physiological information parameters, wherein the physiological information parameters include the animal's heart rate, respiratory rate, body temperature, blood oxygen saturation and number of steps.
  • the animal vital signs real-time monitoring system overcomes the defects of the existing animal physiological information monitoring devices, such as complex systems, inability to wear, single measurement parameters, and need for in vivo implantation, and realizes real-time monitoring of the heart rate, respiratory rate, body temperature, blood oxygen and other physiological information of the small animal during exercise without interfering with the normal life activities of the small animal. It can monitor and remotely record the changes in the vital signs data of mice in real time and obtain better data results.
  • FIG1 is a schematic diagram of the structure of a real-time monitoring system for animal vital signs provided in an embodiment of the present application.
  • FIG2 is a schematic diagram of the structure of a wearable fabric provided in an embodiment of the present application.
  • FIG3 is a schematic diagram of a configuration page of the information analysis platform provided in Example 1 of the present application.
  • FIG4 is a schematic diagram of a system overview page of the information analysis platform provided in Example 1 of the present application.
  • FIG5 is a diagram showing the effect after the experiment provided in Example 1 of the present application.
  • first and second are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, a feature defined as “first” or “second” may explicitly or implicitly include one or more of the features. In the description of this application, the meaning of “plurality” is two or more, unless otherwise clearly and specifically defined.
  • Fig. 1 is a schematic diagram of the structure of a real-time monitoring system for animal vital signs provided by an embodiment of the present application, including: a signal acquisition sensor 110, a wearable fabric 120 and a signal analysis platform 130.
  • a signal acquisition sensor 110 a wearable fabric 120
  • a signal analysis platform 130 a signal analysis platform 130.
  • the signal acquisition sensor 110 is used to detect physiological information parameters, including animal heart rate, respiratory rate, body temperature, blood oxygen saturation and movement steps.
  • the information acquisition sensor 110 is connected to the embedded main control STM32F103C8T6, and receives the physiological information parameters using a Bluetooth gateway through a broadcast protocol, and transmits the physiological information parameters to the signal analysis platform.
  • the signal analysis platform obtains the animal's heart rate, respiratory rate, body temperature, blood oxygen saturation and exercise steps based on the physiological information parameters.
  • the wearable fabric 120 is made of elastic woven fabric.
  • a fixing pocket for fixing the signal acquisition sensor 110 is provided at a position of the wearable fabric 120 close to the animal's heart.
  • the signal acquisition sensor 110 includes a PPG green light module, and the PPG green light module obtains dynamic heart rate parameters according to photoplethysmography.
  • the signal analysis platform performs time domain analysis on the dynamic heart rate parameters to calculate the heart rate value.
  • the signal acquisition sensor 110 includes a PPG red light and infrared light module.
  • the PPG red light and infrared light module obtains the blood oxygen saturation parameter according to the different absorption characteristics of oxygenated hemoglobin HbO2 and hemoglobin Hb contained in the blood to light of different wavelengths, and the signal analysis platform calculates the corresponding ratio according to the blood oxygen saturation parameter to obtain the blood oxygen value.
  • the signal acquisition sensor 110 includes a high thermal conductivity temperature sensor, which can continuously measure the animal's body surface temperature, and the signal analysis platform calculates the body temperature through a built-in algorithm based on the body surface temperature.
  • the signal acquisition sensor 110 includes an accelerometer and a gyroscope, using ax , ay , az of the accelerometer and mx , my , mz of the gyroscope, and the signal analysis platform 130 obtains the number of motion steps by using median filtering and peak detection.
  • the signal analysis platform 130 obtains the respiratory rate based on the heart rate value.
  • the real-time monitoring system for animal vital signs provided by the above-mentioned embodiment of the present application, the signal acquisition sensor 110 is used to detect physiological information parameters, the signal acquisition sensor 110 is fixed on the wearable fabric 120, and the signal analysis platform 130 is used to obtain the physiological information parameters and analyze the physiological information parameters, and the physiological information parameters include animal heart rate, respiratory rate, body temperature, blood oxygen saturation and movement steps.
  • the real-time monitoring system for animal vital signs provided by the present application overcomes the defects of the existing animal physiological information monitoring device, such as complex system, inability to wear, single measurement parameters, and need for in vivo implantation, and realizes real-time monitoring of the heart rate, respiratory rate, body temperature, blood oxygen and other physiological information of small animals during exercise without interfering with the normal life activities of small animals. It can monitor and remotely record the changes in the vital signs data of mice in real time, and obtain better data results.
  • mice 6-8 week old healthy white mice are suspended at 5° using the tail suspension method (with the hind limbs unloaded). The mice can grow and move normally.
  • the device consists of three parts: wearable fabric, signal acquisition sensor (mainly optical sensor) and physiological information acquisition and analysis system. (See Figure 1 and Figure 2)
  • the purpose of the wearable clothing is to fix the signal acquisition sensor, read the dynamic heart rate, respiratory rate, body temperature, blood oxygen saturation SPO2 and other data; and at the same time, the mouse can move freely. Therefore, the wearable clothing uses elastic fabric and the size is made according to the body size of the experimental mouse. Leave a hole for the mouse's forelimbs so that the mouse can move freely. In the position of the wearable clothing close to the mouse's heart, leave a fixed pocket for the sensor and a hole for detecting the signal so that the signal can be collected normally.
  • the information acquisition sensor is connected to the embedded main control. STM32F103C8T6, and uses the Bluetooth gateway to receive data through the broadcast protocol. The data is developed into our physiological information acquisition system platform, and the heart rate, respiratory rate, body temperature, blood oxygen saturation SPO2, etc. of the mouse are calculated through relevant algorithms.
  • the specific implementation method is as follows: the dynamic heart rate is measured by the PPG green light module with an accuracy of 5bpm, 10bpm and 15bpm, and the data is broadcast once every 250ms.
  • the power consumption is ultra-low and accurate, supporting broadcast protocol reading and SDK/API APP reading.
  • the photoplethysmography method due to the blood flow in the artery, the absorption of light changes, and the obtained signal is divided into a DC signal and an AC DC signal.
  • the heart rate value is calculated through time domain analysis.
  • a flexible signal acquisition device is designed with a size of 24mm long and 10mm wide.
  • Blood oxygen SPO2 is measured by PPG red light and infrared light modules, with high power consumption of about 800uA. Since oxygenated hemoglobin HbO2 and hemoglobin Hb contained in the blood have different absorption characteristics for light of different wavelengths, the signal analysis platform calculates the corresponding ratio through relevant algorithms to obtain the blood oxygen value.
  • the surface temperature is measured by a high thermal conductivity temperature sensor, which continuously measures the surface temperature of the mouse and broadcasts it continuously. The accuracy is ⁇ 0.1 degrees Celsius.
  • the signal analysis platform calculates the body temperature by combining the surface temperature with the built-in algorithm. The signal analysis platform calculates the respiratory rate in combination with the measured heart rate.
  • the number of steps is mainly obtained by using a x , a y , a z of the accelerometer and m x , my y , m z of the gyroscope, and by using median filtering and peak detection.
  • the sampling rate is 25 Hz.
  • the measured data is uploaded to the physiological information monitoring system via the Bluetooth connection protocol.
  • the first step is to configure the age and weight of the user (i.e., the mouse) and connect the sensor device, as shown in Figure 3, which is a schematic diagram of the configuration page of the information analysis platform provided in this embodiment.
  • the second step is to enter the system overview page and start collecting mouse physiological information, as shown in FIG4 , which is a schematic diagram of the system overview page provided in this embodiment.
  • the third step is to enter the detailed parameter page and observe the real-time data.
  • the heart rate, respiratory rate, and body surface temperature output results every 30 seconds to form a line graph; the blood oxygen output measurement results every 2 minutes and then draw a bar graph.
  • the experimental mouse vital signs monitoring is composed of a non-restrained wearable clothing, a sensor, an experimental mouse, a vital signs observation cabin, and an electronic computer. The experimental mouse is suspended.
  • FIG5 is a diagram showing the effect of the experiment in the embodiment of the present application.
  • the heart rate of the experimental mice can be accurately measured and recorded, and it can be seen that the result meets the expectations and requirements.
  • the results show that the present invention has designed a real-time monitoring system for animal vital signs, which can record parameters such as heart rate, respiratory rate, body temperature, blood oxygen saturation SPO2, etc. during the unrestrained movement of small animals, thereby facilitating the exploration of changes in relevant physiological information of small animals during normal life activities.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un système de surveillance en temps réel des signes vitaux d'un animal, comprenant : un capteur d'acquisition de signaux (110), un tissu portable (120) et une plateforme d'analyse de signaux (130). Le capteur d'acquisition de signaux (110) est utilisé pour détecter les paramètres d'informations physiologiques. Le capteur d'acquisition de signaux (110) est fixé sur le tissu portable (120). La plateforme d'analyse de signaux (130) est utilisée pour acquérir les paramètres d'informations physiologiques et analyser les paramètres d'informations physiologiques. Les paramètres d'informations physiologiques comprennent la fréquence cardiaque, la fréquence respiratoire, la température corporelle, la saturation en oxygène du sang et le nombre de pas en mouvement de l'animal. Le système de surveillance en temps réel des signes vitaux d'un animal permet de surmonter les défauts des dispositifs existants de surveillance d'informations physiologiques des animaux, tels que la complexité du système, l'impossibilité d'être porté, un seul paramètre de mesure et la nécessité d'une implantation in vivo, permet de réaliser la surveillance en temps réel d'informations physiologiques telles que la fréquence cardiaque, la fréquence respiratoire, la température corporelle et l'oxygène du sang de petits animaux pendant l'exercice sans interférer avec les activités normales de la vie des petits animaux, et peut surveiller en temps réel et enregistrer à distance les changements des données de signes vitaux de souris.
PCT/CN2022/140572 2022-12-21 2022-12-21 Système de surveillance en temps réel des signes vitaux d'un animal Ceased WO2024130577A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118648878A (zh) * 2024-08-21 2024-09-17 中国人民解放军总医院 一种用于皮肤移植的生命体征监测方法和装置

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105997015A (zh) * 2016-06-12 2016-10-12 浙江大学 一种用于动物生命体征多参数监测的可穿戴设备
US20170112447A1 (en) * 2015-10-23 2017-04-27 Valencell, Inc. Physiological monitoring devices and methods that identify subject activity type
US20170172433A1 (en) * 2014-02-14 2017-06-22 Lifeq Global Limited Transcutaneous Photoplethysmography
CN109394189A (zh) * 2018-12-06 2019-03-01 台州市航科电子科技有限公司 一种无创式连续多参数监测的智能穿戴式生物监测装置
US20200345252A1 (en) * 2017-11-16 2020-11-05 Koninklijke Philips N.V. System and method for sensing physiological parameters
US20200367764A1 (en) * 2018-02-15 2020-11-26 Biosency Monitoring device for monitoring a physiological parameter and methods thereof
CN115429251A (zh) * 2021-06-03 2022-12-06 安徽华米健康科技有限公司 可穿戴设备及其监测方法和监测装置

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170172433A1 (en) * 2014-02-14 2017-06-22 Lifeq Global Limited Transcutaneous Photoplethysmography
US20170112447A1 (en) * 2015-10-23 2017-04-27 Valencell, Inc. Physiological monitoring devices and methods that identify subject activity type
CN105997015A (zh) * 2016-06-12 2016-10-12 浙江大学 一种用于动物生命体征多参数监测的可穿戴设备
US20200345252A1 (en) * 2017-11-16 2020-11-05 Koninklijke Philips N.V. System and method for sensing physiological parameters
US20200367764A1 (en) * 2018-02-15 2020-11-26 Biosency Monitoring device for monitoring a physiological parameter and methods thereof
CN109394189A (zh) * 2018-12-06 2019-03-01 台州市航科电子科技有限公司 一种无创式连续多参数监测的智能穿戴式生物监测装置
CN115429251A (zh) * 2021-06-03 2022-12-06 安徽华米健康科技有限公司 可穿戴设备及其监测方法和监测装置

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118648878A (zh) * 2024-08-21 2024-09-17 中国人民解放军总医院 一种用于皮肤移植的生命体征监测方法和装置

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