WO2024113180A1 - Radioactive medicament injection device and working method therefor - Google Patents

Abstract

Provided are a radioactive medicament injection device and a working method therefor. The radioactive medicament injection device comprises a base, an injection needle, an injector assembly, and a pushing assembly. The injection needle is arranged on the base. The injector assembly is arranged on the base, and the injector assembly can move in a first direction relative to the base. The injector assembly has a first position and a second position. The injector assembly comprises a first injector and a second injector. Normal saline is provided in the first injector, and a radioactive medicament is provided in the second injector. The pushing assembly is arranged on the base. The pushing assembly can move in a second direction relative to the base. The first direction is perpendicular to the second direction. Under the condition that the injector assembly is located at the first position, the first injector communicates with the injection needle, and the pushing assembly moves in the second direction and pushes the first injector. Under the condition that the injector assembly is located at the second position, the second injector communicates with the injection needle, and the pushing assembly moves in the second direction and pushes the second injector.

Description

Radiopharmaceutical injection device and working method thereof Technical Field

The present application belongs to the technical field of medical devices, and in particular, relates to a radioactive drug injection device and a working method thereof.

Background technique

In the imaging diagnosis of radionuclides, dynamic imaging technology is a commonly used diagnostic technology. For example, the application of renal dynamic imaging technology to diagnose renal function, the application of three-phase bone imaging technology to diagnose osteomyelitis, and the application of cerebrovascular dynamic imaging technology to diagnose cerebrovascular diseases all play a vital role. Dynamic imaging technology usually requires the use of bolus injection method for intravenous injection of radionuclides. High-concentration, small-volume radioactive drugs are injected into the vein under high pressure, so that the radioactive drugs enter the organs to be detected in a highly aggregated state. This method puts higher requirements on artificial injection. According to statistics, the failure rate of artificial bolus injection is about 5%, and the suboptimal rate is about 10%. Failure of bolus injection is a common pain point problem that has no good solution. Especially in renal dynamic imaging, poor bolus injection quality will directly cause a false decrease in glomerular filtration rate (GFR), thereby affecting the accuracy of imaging diagnosis results. Bolus injection depends on the doctor's operating experience. If the bolus injection fails, the patient will not be able to continue with subsequent imaging on the same day, and even experienced doctors still bear a great psychological burden. In terms of injection safety, the radiation protection provided by the syringe shielding sleeve is only about 46% due to the necessary exposed interface.

Summary of the invention

The embodiments of the present application provide a radiopharmaceutical injection device and a working method thereof, which are used to solve the problem of pellet failure risk and radiation damage caused by the instability of artificial injection of radiopharmaceuticals.

An embodiment of the first aspect of the present application also provides a radioactive drug injection device, comprising: a base; an injection needle, which is arranged on the base; a syringe assembly, which is arranged on the base, and the syringe assembly can move along a first direction relative to the base, the syringe assembly has a first position and a second position, the syringe assembly includes a first syringe and a second syringe, the first syringe is provided with physiological saline, and the second syringe is provided with a radioactive drug; a pushing assembly, which is arranged on the base, and the pushing assembly can move along a second direction relative to the base, and the first direction is perpendicular to the second direction; wherein, when the syringe assembly is located at the first position, the first syringe is connected to the injection needle, and the pushing assembly moves along the second direction and pushes the first syringe; when the syringe assembly is located at the second position, the second syringe is connected to the injection needle, and the pushing assembly moves along the second direction and pushes the second syringe.

In some optional embodiments, the injection needle includes: an injection part, which can be connected to the patient's vein; a movable part, which is arranged on the base and can move along the second direction relative to the base, the movable part and the pushing component are arranged at a distance, and the first syringe or the second syringe is arranged between the movable part and the pushing component, wherein when the movable part moves along the second direction, the movable part can be connected with the first syringe or the second syringe.

In some optional embodiments, it also includes: a shielding component, which is disposed on the base, the shielding component has a receiving space, the second syringe is disposed in the receiving space, and the shielding component can move along the first direction relative to the base with the second syringe.

In some optional embodiments, the shielding assembly includes: a shell, which is arranged on the base, and the shell is provided with a accommodating cavity; a first shielding body and a second shielding body, the first shielding body and the second shielding body are arranged in the accommodating cavity, one end of the second shielding body is sleeved on the first shielding body, and the first shielding body can move relative to the second shielding body, the first shielding body and the second shielding body are both hollow structures, and the first shielding body and the second shielding body form a receiving space, wherein, when the movable part moves along the second direction, the movable part drives the first shielding body to move relative to the second shielding body, so that the second syringe extends out of the first shielding body and is connected with the movable part.

In some optional embodiments, the shielding assembly further includes: an elastic member, which is sleeved on the first shielding body, wherein one end of the elastic member is connected to the first shielding body, and the other end of the elastic member is abutted against the second shielding body.

In some optional embodiments, the shielding assembly also includes: a third shielding body, connected to the second shielding body, the third shielding body includes a connecting portion and an extending portion, the connecting portion is connected to the second shielding body, the connecting portion is provided with a through hole, the extending portion is connected to the peripheral side of the through hole and extends in a direction away from the connecting portion, the syringe barrel of the second syringe is arranged in the accommodating space, and the push handle passes through the through hole and is arranged in the extending portion.

In some optional embodiments, the extending portion is provided with a through slot extending along the second direction, and the pushing position of the second syringe can be observed through the through slot.

In some optional embodiments, scales are provided on the circumference of the through groove, and the scales are used to indicate the pushing distance of the second syringe.

In some optional embodiments, the shell is provided with a limiting groove, and the limiting groove is used to connect with the protection component.

In some optional embodiments, the protective component includes a limit block, a first protective cover and a second protective cover, the first protective cover and the second protective cover are detachably connected, the first protective cover and the second protective cover are hollow structures, and the first protective cover and the second protective cover form a receiving cavity, the shielding component is arranged in the receiving cavity, the limit block is arranged on the side of the first protective cover close to the limit groove, and the limit block is cooperatively connected with the limit groove.

In some optional embodiments, the protection component further includes: a blocking member, which is disposed in the receiving cavity, one end of the blocking member is connected to the first protection sleeve, and the other end of the blocking member is abutted against the first shielding body.

In some optional embodiments, the moving component includes: a slide rail, which is disposed on the base and extends along the second direction; a pressure sensor, which is disposed on the base and connected to the pushing member; a pushing member, which is slidably disposed on the slide rail; and a first driving member, which is connected to the pushing member and can drive the pushing member to slide along the second direction to push the first syringe or the second syringe.

In some optional embodiments, the pushing assembly also includes: a slider, which is slidably disposed on the slide rail and is spaced apart from the pushing member, and the movable part is connected to the slider; a second driving member, which is connected to the slider, and the second driving member can drive the slider to slide along the second direction so that the movable part is connected to the first syringe or the second syringe.

In some optional embodiments, it also includes: a movable plate, which is arranged on the base and can move relative to the base in a first direction, and the first syringe and the second syringe are respectively connected to the movable plate; a nut, which is arranged on the movable plate and connected to the movable plate, and the movable plate is provided with a nut, and the nut is fixed to the movable plate; a lead screw, which is arranged on the base and connected to the nut, and the rotation of the lead screw drives the nut to move in the first direction; a third driving member, which is connected to the lead screw, and the third driving member can drive the lead screw to rotate and drive the movable plate to move in the first direction through the nut.

In some optional embodiments, the movable plate is provided with a first clamping member, and the first clamping member can clamp the first syringe; and/or, the movable plate is provided with a second clamping member, and the second clamping member can clamp the second syringe.

In some optional embodiments, it also includes: a hemostasis component, which is arranged on the base. The hemostasis component includes a tourniquet and an air pump. The air pump is arranged on the base and connected to the tourniquet.

In some optional embodiments, the pushing component includes a direct injection mode and a bolus injection mode; the pushing component is configured to push the first syringe and the second syringe to complete the injection work in the direct injection mode; the pushing component is configured to push the first syringe at a first frequency when the tourniquet is filled to stop bleeding in the bolus injection mode, and after the tourniquet is released, the pushing component pushes the first syringe at a second frequency to complete the injection work.

In some optional embodiments, the first frequency is that at the same peak injection speed and injection volume, the volume of a single pulse push is less than or equal to 0.1 ml; the second frequency is that at the same peak injection speed and injection volume, the volume of a single pulse push is greater than 1 ml.

An embodiment of the second aspect of the present application also provides a working method of an injection device, comprising the following steps: connecting a first syringe with an injection needle, and pushing the first syringe by a pushing assembly so that the physiological saline in the first syringe fills the injection needle; after venous puncture, connecting a second syringe with the injection needle, and pushing the second syringe by a pushing assembly so that the radioactive drug in the second syringe enters the injection needle tube; connecting the first syringe with the injection needle, and pushing the first syringe by a pushing assembly so that the physiological saline in the first syringe is injected into the recipient through the injection needle in a direct injection mode or a pulse injection mode.

In some optional embodiments, the pulse injection mode specifically includes: using an air pump to inflate the tourniquet to stop bleeding, pushing the first syringe at a first frequency, releasing the tourniquet after completing the predetermined volume push, and pushing the first syringe at a second frequency, wherein the first frequency is a single pulse push volume less than or equal to 0.1 ml at the same peak injection speed and injection volume; and the second frequency is a single pulse push volume greater than 1 ml at the same peak injection speed and injection volume.

In the radiopharmaceutical injection device provided in the embodiment of the present application, by setting a syringe assembly and a push assembly, the syringe assembly can move relative to the base in a first direction, alternately changing the positions of the first syringe and the second syringe, so as to achieve the first syringe and the injection needle are connected or the second syringe and the injection needle are connected, and the push assembly can move in the second direction to push the first syringe and the second syringe, and the appropriate injection mode can be selected according to the actual situation, so as to achieve different injection methods, so as to meet the requirements of direct injection or bolus injection, so as to ensure the injection effect of the radiopharmaceutical. In addition, the above radiopharmaceutical injection device can also reduce the contact between the operator and the second syringe, the injection needle, etc., thereby reducing the problem of the operator being exposed to radiation for a long time.

BRIEF DESCRIPTION OF THE DRAWINGS

In order to more clearly illustrate the technical solution of the embodiments of the present application, the following is a brief introduction to the drawings required for use in the embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

FIG1 is a schematic structural diagram of a radiopharmaceutical injection device according to an embodiment of the present application;

2 is a schematic structural diagram of a syringe assembly of a radiopharmaceutical injection device according to an embodiment of the present application in a first position;

3 is a schematic structural diagram of a syringe assembly of a radiopharmaceutical injection device according to an embodiment of the present application in a second position;

FIG4 is an exploded schematic diagram of a shielding assembly of a radiopharmaceutical injection device according to an embodiment of the present application;

FIG5 is a schematic structural diagram of a shielding assembly of a radiopharmaceutical injection device according to an embodiment of the present application;

FIG6 is a partial structural schematic diagram of a radiopharmaceutical injection device according to an embodiment of the present application;

FIG7 is a cross-sectional view of a radiopharmaceutical injection device according to an embodiment of the present application;

FIG8 is a schematic diagram of the structure of the hemostasis component of the radiopharmaceutical injection device according to an embodiment of the present application.

Description of reference numerals:

100. Radiopharmaceutical injection device;

10. Base;

20. injection needle; 21. injection part; 22. active part;

30. syringe assembly; 31. first syringe; 32. second syringe;

40. Pushing assembly; 41. Slide rail; 42. Pushing member; 43. First driving member; 44. Pressure sensor; 45. Sliding block; 46. Second driving member;

50. Shielding assembly; 51. Shell; 52. First shielding body; 53. Second shielding body; 54. Elastic member; 55. Third shielding body;

60. Moving plate; 61. First clamping member; 62. Second clamping member;

70. Screw;

80. A third driving member;

90. Hemostatic component; 91. Tourniquet; 911. Shell; 912. Airbag; 913. Flexible cloth.

Detailed ways

The features and exemplary embodiments of various aspects of the present application will be described in detail below. In the detailed description below, many specific details are proposed to provide a comprehensive understanding of the present application. However, it is obvious to those skilled in the art that the present application can be implemented without the need for some of these specific details. The following description of the embodiments is only to provide a better understanding of the present application by illustrating examples of the present application. In the accompanying drawings and the following description, at least part of the known structures and technologies are not shown to avoid unnecessary ambiguity in the present application; and, for clarity, the size of some structures may be exaggerated. In addition, the features, structures or characteristics described below may be combined in one or more embodiments in any suitable manner.

In the description of the present application, it should be noted that, unless otherwise specified, "plurality" means more than two; the directions or positional relationships indicated by the terms "upper", "lower", "left", "right", "inner", "outer", etc. are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as limiting the present application. In addition, the terms "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.

The directional words appearing in the following description are all directions shown in the figures, and do not limit the specific structure of the embodiments of the present application. In the description of the present application, it should also be noted that, unless otherwise clearly specified and limited, the terms "installation" and "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be directly connected or indirectly connected. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to the specific circumstances.

In order to solve the existing technical problems, the embodiment of the present application provides a radiopharmaceutical injection device and a working method of the injection device. In order to better understand the present application, the radiopharmaceutical injection device and the working method of the injection device of the embodiment of the present application are described in detail below in conjunction with Figures 1 to 8.

The following first introduces the radiopharmaceutical injection device provided in the embodiment of the present application.

Please refer to Figures 1 and 2, Figure 1 is a schematic diagram of the structure of the radiopharmaceutical injection device of an embodiment of the present application; Figure 2 is a schematic diagram of the structure of the syringe assembly of the radiopharmaceutical injection device of an embodiment of the present application is located in a first position; Figure 3 is a schematic diagram of the structure of the syringe assembly of the radiopharmaceutical injection device of an embodiment of the present application is located in a second position; Figure 4 is a schematic diagram of the decomposition of the shielding assembly of the radiopharmaceutical injection device of an embodiment of the present application.

As shown in Figures 1, 2, 3 and 4, an embodiment of the first aspect of the present application provides a radioactive drug injection device 100, comprising: a base 10; an injection needle 20, which is arranged on the base 10; a syringe assembly 30 is arranged on the base 10, and the syringe assembly 30 can move along a first direction relative to the base 10, the syringe assembly 30 has a first position and a second position, the syringe assembly 30 includes a first syringe 31 and a second syringe 32, the first syringe 31 is provided with physiological saline, and the second syringe 32 is provided with a radioactive drug; a pushing assembly 40 is arranged on the base 10, and the pushing assembly 40 can move along a second direction relative to the base 10, and the first direction is perpendicular to the second direction, wherein, when the syringe assembly 30 is located at the first position, the first syringe 31 is connected to the injection needle 20, the pushing assembly 40 moves along the second direction and pushes the first syringe 31; when the syringe assembly 30 is located at the second position, the second syringe 32 is connected to the injection needle 20, the pushing assembly 40 moves along the second direction and pushes the second syringe 32.

The base 10 serves as a mounting base for components such as the injection needle 20, the syringe assembly 30 and the push assembly 40, and provides support for the injection needle 20, the syringe assembly 30 and the push assembly 40, and at least provides a movable space for the syringe assembly 30 and the push assembly 40, so that the syringe assembly 30 moves in a first direction relative to the base 10, and the push assembly 40 moves in a second direction relative to the base 10. The shape, size, etc. of the above-mentioned base 10 can be set according to actual needs. For example, the shape of the base 10 can be selected from a rectangular structure, a trapezoidal structure, a cylindrical structure, and the like.

The syringe assembly 30 is disposed on the base 10, and the syringe assembly 30 can move relative to the base 10 in a first direction. The syringe assembly 30 includes a first syringe 31 and a second syringe 32. The first syringe 31 is provided with saline solution, and the second syringe 32 is provided with a radioactive drug. When the syringe assembly 30 moves to the first position, the first syringe 31 is connected to the injection needle 20. By pushing the first syringe 31, the saline solution in the first syringe 31 is pushed into the injection needle 20 to discharge the bubbles in the injection needle 20. When the syringe assembly 30 moves to the second position, the second syringe 32 is connected to the injection needle 20. By pushing the second syringe 32, the radioactive drug in the second syringe 32 is pushed into the injection needle 20, so that the radioactive drug is injected into the recipient through the injection needle 20. The syringe assembly 30 can reciprocate in the first direction, so that the first syringe 31 and the second syringe 32 are alternately connected to the injection needle 20.

The pushing assembly 40 can move along the second direction relative to the base 10 . The pushing assembly 40 is used to push the first syringe 31 and the second syringe 32 so that the physiological saline in the first syringe 31 or the radioactive drug in the second syringe 32 is pushed into the injection needle 20 .

In the embodiment of the present application, as shown in Figures 2 and 3, when the syringe assembly 30 moves along the first direction and the first syringe 31 approaches the injection needle 20, the first syringe 31 can be driven by the syringe assembly 30 to move toward the injection needle 20, so that the first syringe 31 is connected with the injection needle 20, and the syringe assembly 30 is in the first position at this time; or, when the syringe assembly 30 moves along the first direction and the first syringe 31 approaches the injection needle 20, the injection needle 20 can move toward the first syringe 31, so that the first syringe 31 is connected with the injection needle 20, and the syringe assembly 30 is in the first position at this time. Similarly, when the syringe assembly 30 moves along the first direction and the second syringe 32 approaches the injection needle 20, the second syringe 32 can be driven by the syringe assembly 30 to move toward the injection needle 20, so that the second syringe 32 is connected to the injection needle 20, and the syringe assembly 30 is in the second position at this time; or, when the syringe assembly 30 moves along the first direction and the second syringe 32 approaches the injection needle 20, the injection needle 20 can move toward the second syringe 32, so that the second syringe 32 is connected to the injection needle 20, and the syringe assembly 30 is in the second position at this time.

Optionally, the pushing assembly 40 and the injection needle 20 are on the same straight line along the second direction.

Optionally, when the base 10 is a rectangular structure, the first direction is the X direction, that is, the width direction of the base 10, and the second direction is the Y direction, that is, the length direction of the base 10, and the first direction is perpendicular to the second direction.

In the radiopharmaceutical injection device 100 provided in the embodiment of the present application, the syringe assembly 30 and the push assembly 40 are provided. The syringe assembly 30 can move along the first direction relative to the base 10, and the positions of the first syringe 31 and the second syringe 32 are alternately changed, so as to realize the communication between the first syringe 31 and the injection needle 20 or the communication between the second syringe 32 and the injection needle 20. The push assembly 40 can move along the second direction to push the first syringe 31 and the second syringe 32. The appropriate injection mode of the push assembly 40 can be selected according to the actual situation, so as to realize different injection methods, so as to meet the requirements of direct injection or bolus injection, and ensure the injection effect of the radiopharmaceutical. In addition, the radiopharmaceutical injection device 100 can also reduce the contact between the operator and the second syringe 32, the injection needle 20, etc., so as to reduce the problem of the operator being exposed to radiation for a long time.

In some optional embodiments, as shown in Figures 1 and 4, the injection needle 20 includes: an injection part 21 that can be connected to the vein of the recipient; a movable part 22 is arranged on the base 10, and the movable part 22 can move along the second direction relative to the base 10, the movable part 22 and the pushing component 40 are arranged at a distance, and the first syringe 31 or the second syringe 32 is arranged between the movable part 22 and the pushing component 40, wherein when the movable part 22 moves along the second direction, the movable part 22 can be connected to the first syringe 31 or the second syringe 32.

In the embodiment of the present application, the injection needle 20 includes an injection part 21 and a movable part 22. The injection part 21 can be connected to the vein of the recipient, the movable part 22 can be connected to the first syringe 31 or the second syringe 32, and the movable part 22 can move along the second direction relative to the base 10, thereby realizing the connection or disconnection of the movable part 22 with the first syringe 31, or the connection or disconnection with the second syringe 32.

Exemplarily, when the first syringe 31 and the second syringe 32 move synchronously along the first direction and the first syringe 31 moves to align with the movable part 22, the movable part 22 moves along the second direction toward the first syringe 31 to connect the first syringe 31 with the movable part 22, and the pushing assembly 40 moves along the second direction and pushes the first syringe 31 to inject the physiological saline in the first syringe 31 into the injection needle 20.

Exemplarily, when the first syringe 31 and the second syringe 32 move synchronously along the first direction and the second syringe 32 moves to align with the movable part 22, the movable part 22 moves along the second direction toward the second syringe 32 so that the second syringe 32 is connected to the movable part 22, and the pushing assembly 40 moves along the second direction and pushes the second syringe 32 so that the radioactive drug in the second syringe 32 is injected into the injection needle 20.

In these optional embodiments, the first syringe 31 and the second syringe 32 are configured to move in a first direction, and the push assembly 40 and the movable portion 22 move in a second direction. Each component moves in only one direction, thereby simplifying the overall operation of the above-mentioned device and ensuring the movement stability of each component to achieve precise operation, thereby ensuring the injection effect of the radioactive drug.

In some optional embodiments, as shown in Figures 1 and 4, a shielding assembly 50 is further included, which is disposed on the base 10. The shielding assembly 50 has a receiving space, and the second syringe 32 is disposed in the receiving space. The shielding assembly 50 can move along the first direction relative to the base 10 together with the second syringe 32.

In the embodiment of the present application, the shielding assembly 50 has a receiving space, and at least a portion of the second syringe 32 is arranged in the receiving space. It can be understood that the second syringe 32 is completely embedded in the receiving space of the shielding assembly 50, and the receiving space is a non-closed space. At this time, the movable part 22 can extend into the receiving space to communicate with the second syringe 32, and the pushing assembly 40 can extend into the receiving space and push the push handle of the second syringe 32 to move.

In the embodiment of the present application, the shielding assembly 50 may be an integral structure or a split structure.

In these optional embodiments, the shielding assembly 50 is provided to provide radiation protection. When the pushing assembly 40 moves along the second direction and pushes the second syringe 32 to inject the radioactive drug in the second syringe 32 into the injection needle 20, the shielding assembly 50 can play a protective role and further reduce the radiation exposure of the operator.

Please refer to FIG. 5 , which is a schematic diagram of the structure of the shielding assembly of the radiopharmaceutical injection device according to an embodiment of the present application.

In some optional embodiments, as shown in Figures 4 and 5, the shielding assembly 50 includes: a shell 51, which is arranged on the base 10, and the shell 51 is provided with a accommodating cavity; a first shielding body 52 and a second shielding body 53, the first shielding body 52 and the second shielding body 53 are arranged in the accommodating cavity, one end of the second shielding body 53 is sleeved on the first shielding body 52, and the first shielding body 52 can move relative to the second shielding body 53, the first shielding body 52 and the second shielding body 53 are both hollow structures, and the first shielding body 52 and the second shielding body 53 form a receiving space, wherein, when the movable part 22 moves along the second direction, the movable part 22 drives the first shielding body 52 to move relative to the second shielding body 53, so that the second syringe 32 extends out of the first shielding body 52 and communicates with the movable part 22.

In the embodiment of the present application, the shielding assembly 50 includes a shell 51, a first shielding body 52, and a second shielding body 53. The shell 51 is sleeved outside the first shielding body 52 and the second shielding body 53, and one end of the shell 51 can be connected to the movable part 22. The first shielding body 52 and the second shielding body 53 are both hollow structures, and the first shielding body 52 and the second shielding body 53 form a receiving space, and the second syringe 32 is embedded in the receiving space. One end of the second shielding body 53 is sleeved on the first shielding body 52, and the first shielding body 52 can move relative to the second shielding body 53. It can be understood that the first shielding body 52 is telescopic relative to the second shielding body 53. When the first shielding body 52 is in an extended state, the second syringe 32 is arranged in the first shielding body 52, and the second syringe 32 is not connected with the movable part 22; when the first shielding body 52 is in a retracted state, the second syringe 32 extends out of the first shielding body 52 and is connected with the movable part 22. At this time, the retracted state of the first shielding body 52 is based on the movable part 22 pressing the first shielding body 52 to move toward the second shielding body 53, so that the first shielding body 52 is in a retracted state.

In these optional embodiments, the housing 51 is sleeved on the first shielding body 52 and the second shielding body 53, and the second syringe 32 is arranged in the receiving space formed by the first shielding body 52 and the second shielding body 53. When the syringe assembly 30 is located at the first position, the syringe of the radioactive drug in the second syringe 32 is sleeved with the first shielding body 52, which effectively reduces the radiation of the radioactive drug. When the syringe assembly 30 is located at the second position, the first shielding body 52 contacts the movable part 22, and the first shielding body 52 retracts, and the second syringe 32 extends out of the first shielding body 52 and communicates with the movable part 22. When the pushing assembly 40 pushes the second syringe 32 so that the radioactive drug in the second syringe 32 is injected into the injection needle 20, the first shielding body 52 contacts the movable part 22 to form a relatively connected space between the second syringe 32 passing through the movable part 22 and the injection needle 20, so that the radioactive drug is injected into the injection needle 20.

In some optional embodiments, the shielding assembly 50 further includes an elastic member 54 which is sleeved on the first shielding body 52 . One end of the elastic member 54 is connected to the first shielding body 52 , and the other end thereof is abutted against the second shielding body 53 .

Optionally, the elastic member 54 is selected from at least one of a linear spring, a torsion spring, a spring sheet, a solid elastic rubber, a porous elastic rubber, a solid elastic plastic, a porous elastic plastic, a memory metal and a magnetic member.

In these optional embodiments, the elastic member 54 provides a thrust to the first shielding body 52. When the first shielding body 52 is compressed by the movable portion 22 to reach a retracted state, the elastic member 54 is in a state of contraction and deformation due to the external load. When the movable portion 22 releases the pressure on the first shielding body 52, based on the rebound force (thrust) of the elastic member 54 after contraction, the first shielding body 52 moves in a direction away from the second shielding body 53, so that the first shielding body 52 automatically returns to an uncompressed state, and the second syringe 32 is accommodated in the first shielding body 52.

In some optional embodiments, the shielding assembly 50 also includes a third shielding body 55, which is connected to the second shielding body 53. The third shielding body 55 includes a connecting portion and an extending portion. The connecting portion is connected to the second shielding body 53. The connecting portion is provided with a through hole. The extending portion is connected to the peripheral side of the through hole and extends in a direction away from the connecting portion. The syringe barrel of the second syringe 32 is arranged in the accommodating space, and the push handle passes through the through hole and is arranged in the extending portion.

Optionally, the third shielding body 55 is threadedly connected to the second shielding body 53 , so that the third shielding body 55 and the second shielding body 53 are detachable, and the second syringe 32 is placed in the third shielding body 55 and the second shielding body 53 and extends to the first shielding body 52 .

Optionally, an end of the push handle of the second syringe 32 is located on the third shielding body 55 .

In these optional embodiments, such configuration facilitates installation and removal of the second syringe 32 .

In some optional embodiments, the extension portion is provided with a through slot extending along the second direction, and the pushing position of the second syringe 32 can be observed through the through slot.

In these optional embodiments, the pushing position of the second syringe 32 can be observed through the through slot, so as to determine the pushing status of the second syringe 32 and the remaining status of the radioactive drug in the second syringe 32.

In some optional embodiments, scales are provided on the circumference of the through groove, and the scales are used to indicate the pushing distance of the second syringe 32 .

In these optional embodiments, by reading the scale position corresponding to the end of the second syringe 32, the volume of the radioactive drug in the second syringe 32 inside the shielding assembly 50 can be read without contacting the second syringe 32.

In some optional embodiments, the housing 51 is provided with a limiting groove, and the limiting groove is used to connect with the protection component.

In the embodiment of the present application, the protection component is connected to the housing 51 via a limiting groove, the protection component includes a slider 45 slidably connected to the limiting groove, and the protection component may also include a protrusion that is snap-fitted to the limiting groove.

In these optional embodiments, the protective component can be mounted on the housing 51. Since the housing 51 is not completely closed, the protective component needs to be mounted during transportation. The protective component is opened before injection, and the shielding component 50 containing the second syringe 32 is placed in the radiopharmaceutical injection device 100 to complete the injection. When the injection is completed, it needs to be taken out of the radiopharmaceutical injection device 100 and put back into the protective component to avoid radiation leakage.

In some optional embodiments, the protection component includes a limit block, a first protective cover and a second protective cover, the first protective cover and the second protective cover are detachably connected, the first protective cover and the second protective cover are hollow structures, and the first protective cover and the second protective cover form a receiving cavity, the shielding component 50 is arranged in the receiving cavity, the limit block is arranged on the side of the first protective cover close to the limit groove, and the limit block is cooperatively connected with the limit groove.

In these optional embodiments, the limiting block is disposed on one side of the first protective cover close to the limiting groove, and is used to slide with the limiting groove, thereby guiding the shielding assembly 50 to be inserted into the first protective cover, and limiting the shielding assembly 50 to move in the receiving cavity formed by the first protective cover and the second protective cover, thereby reducing the frequent collision between the shielding assembly 50 and the protective cover, thereby reducing the leakage of internal radioactive drugs. In addition, when the shielding assembly 50 is disposed in the protective cover, the first protective cover can be separated from the second protective cover, and the shielding assembly 50 can be taken out by holding the third shielding body 55.

In some optional embodiments, the protection assembly further includes a blocking member disposed in the receiving cavity, one end of the blocking member is connected to the first protection sleeve, and the other end of the blocking member is in contact with the first shielding body 52 .

In these optional embodiments, the blocking member cooperates with the first shielding body 52 to block the radiation leakage at the open end of the first shielding body 52, that is, the connection between the first shielding body 52 and the movable part 22. In addition, one end of the blocking component is connected to the first protective sleeve, and the other end is abutted against the first shielding body 52, which can further limit the movement of the shielding component 50 in the protective component.

6 and 7 , FIG. 6 is a schematic diagram of a portion of the structure of a radiopharmaceutical injection device according to an embodiment of the present application; and FIG. 7 is a cross-sectional view of the radiopharmaceutical injection device according to an embodiment of the present application.

In some optional embodiments, as shown in Figures 6 and 7, the pushing assembly 40 includes: a slide rail 41, which is disposed on the base 10, and the slide rail 41 extends along the second direction; a pushing member 42, which is slidably disposed on the slide rail 41; a pressure sensor 44, which is disposed on the base 10 and connected to the pushing member 42; a first driving member 43, which is connected to the pushing member 42, and the first driving member 43 can drive the pushing member 42 to slide along the second direction to push the first syringe 31 or the second syringe 32.

In an embodiment of the present application, the pushing assembly 40 includes a slide rail 41, a pushing member 42, a first driving member 43 and a pressure sensor 44. The first driving member 43 drives the pushing member 42 to move along the second direction on the slide rail 41. The pushing member 42 can approach or move away from the first syringe 31 or the second syringe 32 along the second direction. The pressure sensor 44 can contact the push handle of the first syringe 31 or the second syringe 32 to detect the injection force during the injection process to identify whether a blockage occurs.

Exemplarily, when the first syringe 31 and the second syringe 32 move synchronously along the first direction, and the first syringe 31 moves to align with the movable part 22, the movable part 22 moves along the second direction toward the first syringe 31, so that the first syringe 31 is connected with the movable part 22, and the first driving member 43 drives the pusher 42 to move in the second direction close to the first syringe 31, the pusher 42 abuts against the first syringe 31, and the first driving member 43 continuously works so that the pusher 42 pushes the first syringe 31, so that the saline in the first syringe 31 is injected into the injection needle 20. After the injection of the saline is completed, the movable part 22 moves in the second direction away from the first syringe 31, the first syringe 31 is disconnected from the movable part 22, and the first driving member 43 drives the pusher 42 to move in the second direction away from the first syringe 31.

Exemplarily, when the second syringe 32 moves synchronously with the second syringe 32 along the first direction, and the second syringe 32 moves to align with the movable part 22, the movable part 22 moves along the second direction toward the second syringe 32, so that the second syringe 32 is connected with the movable part 22, and the first driving member 43 drives the pusher 42 to move in the second direction close to the second syringe 32, the pusher 42 abuts against the second syringe 32, and the first driving member 43 continuously works so that the pusher 42 pushes the second syringe 32, so that the radioactive drug in the second syringe 32 is injected into the injection needle 20. After the injection of the radioactive drug is completed, the movable part 22 moves in the second direction away from the second syringe 32, the second syringe 32 is disconnected from the movable part 22, and the first driving member 43 drives the pusher 42 to move in the second direction away from the second syringe 32.

In some optional embodiments, the pushing assembly 40 also includes: a slider 45, which is slidably disposed on the slide rail 41, and the slider 45 and the pushing member 42 are spaced apart, and the movable part 22 is connected to the slider 45; a second driving member 46, which is connected to the slider 45, and the second driving member 46 can drive the slider 45 to slide along the second direction so that the movable part 22 is connected to the first syringe 31 or the second syringe 32.

In these optional embodiments, the movable portion 22 and the slider 45 share a slide rail 41 and can both move along the second direction, thereby simplifying the overall structure of the device.

In some other optional embodiments, as shown in Figure 6, it also includes a slide groove, a slider 45, and a second driving member 46. The slider 45 is slidably set in the slide groove. The slide groove and the slide rail 41 extend along the second direction and are spaced apart, so that the slider 45 and the pushing member 42 are spaced apart and on the same straight line. The second driving member 46 is connected to the slider 45, and the second driving member 46 can drive the slider 45 to slide along the second direction so that the movable part 22 is connected to the first syringe 31 or the second syringe 32.

In some optional embodiments, as shown in Figure 6, it also includes: a movable plate 60, which is disposed on the base 10, and the movable plate 60 can move along the first direction relative to the base 10, the first syringe 31 and the second syringe 32 are respectively connected to the movable plate 60, and the movable plate 60 is provided with a nut, and the nut is fixed to the movable plate 60; a screw 70, the screw 70 is disposed on the base 10 and connected to the nut, and the screw 70 rotates to make the nut move along the first direction; a third driving member 80, which is connected to the screw 70, and the third driving member 80 can drive the screw 70 to rotate through the nut to drive the movable plate 60 to move along the first direction.

In these optional embodiments, the radiopharmaceutical injection device 100 further includes a movable plate 60, a nut, a screw 70 and a third driving member 80, and the screw 70 is driven by the third driving member 80 to rotate through the nut to drive the movable plate 60 to reciprocate along the first direction.

In some optional embodiments, the movable plate 60 is provided with a first clamping member 61 , and the first clamping member 61 can clamp the first syringe 31 .

In some optional embodiments, the movable plate 60 is provided with a second clamping member 62 , and the second clamping member 62 can clamp the second syringe 32 .

Please refer to FIG8 , which is a schematic diagram of the structure of the hemostasis component of the radiopharmaceutical injection device according to an embodiment of the present application.

In some optional embodiments, as shown in FIG. 1 and FIG. 8 , a hemostasis component 90 is further included, which is disposed on the base 10 . The hemostasis component 90 includes a tourniquet 91 and an air pump. The air pump is disposed on the base 10 and connected to the tourniquet 91 .

Optionally, the tourniquet 91 includes a shell 911 , an air bag 912 , and a flexible cloth 913 , and an air pump is connected to the air bag 912 .

In the embodiment of the present application, the design of the tourniquet 91 includes but is not limited to a ring tourniquet, a tie tourniquet, a solid extrusion tourniquet, etc.

In these optional embodiments, by setting up the hemostatic component 90 and cooperating with the injection needle 20, the syringe component 30 and the push component 40, the bolus injection effect is better. The pressure of the tourniquet 91 on the squeezing position can be adjusted by the air pump in conjunction with the air pressure sensor to achieve accurate control of the hemostatic strength. In addition, the setting of the hemostatic component 90 enables the radiopharmaceutical injection device 100 to have an automatic hemostatic function. Due to the application of the automatic hemostatic component 90, the radiopharmaceutical will stay near the tourniquet 91 after the push injection is completed. With the release of the tourniquet 91, due to the effect of the intravenous pressure, the radiopharmaceutical will quickly enter the body along with the blood flow and the saline solution assisted in the push injection. Under the automatic cooperation of this method, the bolus injection effect can be further improved while avoiding the risk of failure.

In some optional embodiments, the push assembly 40 includes a direct injection mode and a bolus injection mode. The push assembly 40 is configured to push the first syringe 31 and the second syringe 32 to complete the injection work in the direct injection mode. The push assembly 40 is configured to push the first syringe 31 and the second syringe 32 to complete the injection work in the bolus injection mode. The push assembly 40 is configured to push the first syringe 31 at a first frequency when the tourniquet 91 is filled to stop bleeding in the bolus injection mode. After the tourniquet 91 is released, the push assembly 40 pushes the first syringe 31 at a second frequency 32 to complete the injection work.

Exemplarily, in the direct push mode, the first syringe 31 is connected to the injection needle 20, and the pushing assembly 40 is configured to push the first syringe 31 at a constant and relatively low pushing speed so that the physiological saline in the first syringe 31 fills the injection needle 20; then the second syringe 32 is connected to the injection needle 20, and the pushing assembly 40 is configured to push the second syringe 32 at a constant and relatively low pushing speed so that the radioactive drug in the second syringe 32 enters the injection needle 20; thereafter, the first syringe 31 is connected to the injection needle 20 again, and the pushing assembly 40 is configured to push the first syringe 31 at a constant and relatively low pushing speed so that the physiological saline in the first syringe 31 pushes the radioactive drug in the injection needle 20 and is injected into the recipient.

Exemplarily, in the pulse injection mode, the first syringe 31 is connected to the injection needle 20, and the pushing assembly 40 is configured to push the first syringe 31 at a constant and relatively low pushing speed so that the physiological saline in the first syringe 31 fills the injection needle 20; then the second syringe 32 is connected to the injection needle 20, and the pushing assembly 40 is configured to push the second syringe 32 at a constant and relatively low pushing speed so that the radioactive drug in the second syringe 32 enters the injection needle 20; thereafter, the first syringe 31 is connected to the injection needle 20 again, at this time, the air pump pressurizes the tourniquet 91 to achieve the hemostatic force, and the pushing assembly 40 is configured to push the first syringe 31 at a first frequency, that is, a single pulse push volume is a pulse volume of less than 0.1 ml for injection; when the flushing volume is reached (usually the first frequency maintains a total volume of no more than 1.5 ml), the tourniquet 91 automatically releases the pressure, and the pushing assembly 40 is configured to push the first syringe 31 at a second frequency, that is, a single pulse push volume is a pulse volume of more than 1 ml for injection until the push is completed.

In some optional embodiments, the first frequency is such that at the same peak injection speed and injection volume, the volume of a single pulse push is less than or equal to 0.1 ml. The second frequency is such that at the same peak injection speed and injection volume, the volume of a single pulse push is greater than 1 ml.

In the embodiment of the present application, the inventor found through the study of the first frequency and the second frequency in the pulse injection mode that a peristaltic pump is used to provide blood flow power, and a simulated bionic arm is used to perform an in vitro bolus injection simulation experiment. When the same total amount of saline is injected, a larger volume of saline bolus helps to improve the injection efficiency, and a smaller volume of saline bolus helps to reduce the effective flushing liquid volume. For example, a single pulse push liquid bolus with a volume of 80 microliters only requires 1.46 ml of saline to completely clean the nucleus in the pipeline, and the liquid consumption is 49% less than that of non-pulse injection. The use of small liquid bolus flushing in the hemostatic state can reduce the risk of damage to the vein. Therefore, using the first frequency to push the first syringe 31 can be understood as a high-frequency small-volume pulse injection, which can reduce the amount of saline solution for flushing the pipeline; using the second frequency to push the first syringe 31 can be understood as a low-frequency large-volume pulse injection, which can improve the injection efficiency. The coordination of the tourniquet can improve the pellet aggregation of the radiopharmaceutical bolus injection, thereby improving the bolus injection effect.

Optionally, in the pulse injection mode, the controller controls the hemostatic component 90 and the pushing component 40 to be in a precise matching state. Such a setting can ensure the consistency of injection and further improve the bolus injection effect.

The embodiment of the second aspect of the present application further provides a working method of an injection device, comprising the following steps:

Connect the first syringe 31 to the injection needle 20, and push the first syringe 31 through the pushing assembly 40 so that the physiological saline in the first syringe 31 fills the injection needle 20;

After the venipuncture, the second syringe 32 is connected to the injection needle 20, and the second syringe 32 is pushed by the pushing assembly 40 so that the radioactive drug in the second syringe 32 enters the injection needle 20;

The first syringe 31 is connected to the injection needle 20 , and the first syringe 31 is pushed by the pushing assembly 40 , so that the physiological saline in the first syringe 31 is injected into the recipient through the injection needle 20 in a direct injection mode or a pulse injection mode.

The working method of the injection device of the present application is to first fill the injection needle 20 with physiological saline to remove the gas in the injection needle 20, and then push the radioactive drug into the injection needle 20 after completing the venous puncture, and then select the direct injection mode or the pulse injection mode to inject it into the recipient through the injection needle 20. The working method of the injection device of the present application can provide doctors with the choice of a suitable injection mode according to actual conditions to achieve the requirements of direct injection or bolus injection to ensure the injection effect of the radioactive drug. In addition, it can also reduce the contact between the operator and the radioactive drug, thereby reducing the problem of the operator being exposed to radiation for a long time.

In the embodiment of the present application, in the direct injection mode, the physiological saline in the first syringe 31 and the radionuclide in the second syringe 32 will be injected into the recipient at a constant and slow speed.

In an embodiment of the present application, the pulse injection mode specifically includes: using an air pump to inflate the tourniquet 91 to stop bleeding, pushing the component 40 to push the first syringe 31 at a first frequency, and after completing the predetermined volume push injection, releasing the tourniquet 91, and pushing the component 40 to push the first syringe 31 at a second frequency, wherein the first frequency is at the same peak injection speed and injection volume, and the single pulse push volume is less than or equal to 0.1 ml; the second frequency is at the same peak injection speed and injection volume, and the single pulse push volume is greater than 1 ml.

In an embodiment of the present application, the radioactive drug is first pushed into the injection needle. Under the hemostatic state, a first frequency push injection of normal saline is used to complete the low-liquid injection needle flushing. After the tourniquet is released, a second frequency push injection of normal saline is used to assist the radioactive drug to enter the human body efficiently. This method can improve the pellet aggregation of the radioactive drug pellet injection, thereby improving the pellet injection effect.

The other components and operations of the radiopharmaceutical injection device according to the embodiment of the present application are known to those of ordinary skill in the art and will not be described in detail here. In the description of this specification, the reference terms "one embodiment", "some embodiments", "exemplarily", "in the embodiment of the present application", etc. mean that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

Although the present application has been described with reference to preferred embodiments, various modifications may be made thereto and parts thereof may be replaced with equivalents without departing from the scope of the present application. In particular, the various technical features mentioned in the various embodiments may be combined in any manner as long as there are no structural conflicts. The present application is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims (20)

A radiopharmaceutical injection device, comprising: Pedestal; An injection needle, disposed on the base; A syringe assembly is disposed on the base and can move relative to the base along a first direction, the syringe assembly has a first position and a second position, the syringe assembly includes a first syringe and a second syringe, the first syringe is provided with physiological saline, and the second syringe is provided with a radioactive drug; A pushing assembly, disposed on the base, the pushing assembly can move relative to the base along a second direction, the first direction being perpendicular to the second direction; Wherein, when the syringe assembly is located at the first position, the first syringe is connected to the injection needle, and the pushing assembly moves along the second direction and pushes the first syringe; When the syringe assembly is located at the second position, the second syringe is connected to the injection needle, and the pushing assembly moves along the second direction and pushes the second syringe. The radiopharmaceutical injection device according to claim 1, wherein the injection needle comprises: An injection portion, which can be connected to a vein of a recipient; A movable part is disposed on the base, and the movable part can move relative to the base along the second direction, the movable part and the pushing component are spaced apart, and the first syringe or the second syringe is disposed between the movable part and the pushing component. Wherein, when the movable part moves along the second direction, the movable part may be connected with the first syringe or the second syringe. The radiopharmaceutical injection device according to claim 2, further comprising: A shielding component is arranged on the base, the shielding component has a receiving space, the second syringe is arranged in the receiving space, and the shielding component can move along a first direction relative to the base together with the second syringe. The radiopharmaceutical injection device according to claim 3, wherein the shielding assembly comprises: A shell, arranged on the base, wherein the shell is provided with a receiving cavity; a first shielding body and a second shielding body, wherein the first shielding body and the second shielding body are arranged in the accommodating cavity, one end of the second shielding body is sleeved on the first shielding body, and the first shielding body can move relative to the second shielding body, the first shielding body and the second shielding body are both hollow structures, and the first shielding body and the second shielding body form the accommodating space, When the movable part moves along the second direction, the movable part drives the first shielding body to move relative to the second shielding body, so that the second syringe extends out of the first shielding body and communicates with the movable part. The radiopharmaceutical injection device according to claim 4, wherein the shielding assembly further comprises: The elastic member is sleeved on the first shielding body, one end of the elastic member is connected to the first shielding body, and the other end of the elastic member is abutted against the second shielding body. The radiopharmaceutical injection device according to claim 4 or 5, wherein the shielding assembly further comprises: A third shielding body is connected to the second shielding body, and the third shielding body includes a connecting portion and an extending portion. The connecting portion is connected to the second shielding body, the connecting portion is provided with a through hole, the extending portion is connected to the peripheral side of the through hole and extends in a direction away from the connecting portion, the syringe of the second syringe is arranged in the accommodating space, and the push handle passes through the through hole and is arranged in the extending portion. The radiopharmaceutical injection device according to claim 6, wherein: The extending portion is provided with a through slot, which extends along the second direction. The pushing position of the second syringe can be observed through the through slot. The radiopharmaceutical injection device according to claim 7, wherein: A scale is provided on the circumference of the through groove, and the scale is used to indicate the pushing distance of the second syringe. The radiopharmaceutical injection device according to any one of claims 4 to 8, wherein: The shell is provided with a limiting groove, and the limiting groove is used to be connected with the protection component. The radiopharmaceutical injection device according to claim 9, wherein: The protection component includes a limit block, a first protective cover and a second protective cover, the first protective cover is detachably connected to the second protective cover, the first protective cover and the second protective cover are hollow structures, and the first protective cover and the second protective cover form a receiving cavity, the shielding component is arranged in the receiving cavity, the limit block is arranged on a side of the first protective cover close to the limit groove, and the limit block is cooperatively connected with the limit groove. The radiopharmaceutical injection device according to claim 10, wherein the protection component further comprises: The blocking member is disposed in the receiving cavity, one end of the blocking member is connected to the first protective sleeve, and the other end of the blocking member is in contact with the first shielding body. The radiopharmaceutical injection device according to any one of claims 2 to 11, wherein the pushing assembly comprises: A slide rail, disposed on the base, and extending along the second direction; A pushing member, slidably disposed on the slide rail; A pressure sensor, disposed on the base and connected to the pushing member; The first driving member is connected to the pushing member, and the first driving member can drive the pushing member to slide along the second direction to push the first syringe or the second syringe. The radiopharmaceutical injection device according to claim 12, wherein the pushing assembly further comprises: A slider, wherein the slider is slidably disposed on the slide rail, the slider is spaced apart from the pusher, and the movable portion is connected to the slider; The second driving member is connected to the slider, and the second driving member can drive the slider to slide along a second direction so that the movable part is connected to the first syringe or the second syringe. The radiopharmaceutical injection device according to any one of claims 1 to 13, further comprising: A movable plate, the movable plate is arranged on the base, and the movable plate can move along a first direction relative to the base, the first syringe and the second syringe are respectively connected to the movable plate, and the movable plate is provided with a nut, and the nut is fixed to the movable plate; A lead screw, the lead screw is disposed on the base and connected to the nut, and the lead screw rotates to make the nut move along a first direction; A third driving member is connected to the lead screw, and the third driving member can drive the lead screw to rotate and drive the movable plate to move along the first direction through the nut. The radiopharmaceutical injection device according to claim 14, wherein: The movable plate is provided with a first clamping member, and the first clamping member can clamp the first syringe; and/or, The movable plate is provided with a second clamping member, and the second clamping member can clamp the second syringe. The radiopharmaceutical injection device according to any one of claims 1 to 15, further comprising: A hemostasis component is arranged on the base, and the hemostasis component comprises a tourniquet and an air pump. The air pump is arranged on the base, and the air pump is connected to the tourniquet. The radiopharmaceutical injection device according to claim 16, wherein: The push assembly includes a direct injection mode and a bolus injection mode; The pushing component is configured to push the first syringe and the second syringe to complete the injection work in the direct injection mode; The pushing component is configured to push the first syringe at a first frequency when the tourniquet is filled to stop bleeding in the bolus injection mode, and after the tourniquet is released, the pushing component pushes the first syringe at a second frequency to complete the injection. The radiopharmaceutical injection device according to claim 17, wherein: The first frequency is that at the same peak injection speed and injection volume, the single pulse injection volume is less than or equal to 0.1 ml; The second frequency is such that, at the same peak injection speed and injection volume, a single pulse injection volume is greater than 1 ml. A method for operating an injection device comprises the following steps: Connecting the first syringe to the injection needle, and pushing the first syringe by the pushing assembly so that the physiological saline in the first syringe fills the injection needle; After venipuncture, a second syringe is connected to the injection needle, and the second syringe is pushed by the pushing assembly so that the radioactive drug in the second syringe enters the injection needle; The first syringe is connected to the injection needle, and the first syringe is pushed by the pushing assembly so that the physiological saline in the first syringe is injected into the recipient through the injection needle in a direct injection mode or a pulse injection mode. The operating method of the injection device according to claim 19, wherein: The pulse injection mode specifically includes: The tourniquet is expanded and hemostasis is stopped by an air pump, the pushing component pushes the first syringe at a first frequency, and after the predetermined volume is pushed, the tourniquet is released, and the pushing component pushes the first syringe at a second frequency. Wherein, the first frequency is that at the same peak injection speed and injection volume, the single pulse injection volume is less than or equal to 0.1 ml; The second frequency is such that, at the same peak injection speed and injection volume, a single pulse injection volume is greater than 1 ml.

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