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WO2024108325A1 - Dispositif de fixation de viscères d'animaux - Google Patents

Dispositif de fixation de viscères d'animaux Download PDF

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Publication number
WO2024108325A1
WO2024108325A1 PCT/CN2022/133122 CN2022133122W WO2024108325A1 WO 2024108325 A1 WO2024108325 A1 WO 2024108325A1 CN 2022133122 W CN2022133122 W CN 2022133122W WO 2024108325 A1 WO2024108325 A1 WO 2024108325A1
Authority
WO
WIPO (PCT)
Prior art keywords
retractable
rocker arm
organ
telescopic
fixing device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2022/133122
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English (en)
Chinese (zh)
Inventor
周圆
李栩琳
王枫
王立平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Institute of Advanced Technology of CAS
Original Assignee
Shenzhen Institute of Advanced Technology of CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenzhen Institute of Advanced Technology of CAS filed Critical Shenzhen Institute of Advanced Technology of CAS
Priority to PCT/CN2022/133122 priority Critical patent/WO2024108325A1/fr
Publication of WO2024108325A1 publication Critical patent/WO2024108325A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
    • A61B90/14—Fixators for body parts, e.g. skull clamps; Constructional details of fixators, e.g. pins
    • A61B90/17—Fixators for body parts, e.g. skull clamps; Constructional details of fixators, e.g. pins for soft tissue, e.g. breast-holding devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/50—Supports for surgical instruments, e.g. articulated arms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Appliances for supporting or fettering animals for operative purposes

Definitions

  • the present application relates to the field of animal experiment technology, and in particular to an animal organ fixing device.
  • peripheral organs have always been an enduring topic in scientific research.
  • researchers can achieve various experimental purposes through live manipulation of peripheral organs, such as direct surgery on organs and indirect imaging of organs.
  • the commonly used methods of peripheral organ fixation are still relatively primitive.
  • direct surgical operations on peripheral organs they are generally fixed manually by the experimenter, or the peripheral organs are placed in a relatively stable position during the experiment, or the peripheral organs are operated in situ by increasing the area of the surgical window.
  • the position of organs is prone to shift during the experiment.
  • organs such as the intestines are prone to peristalsis and retraction.
  • the experimenter manually fixes them or fixes them with tools such as tweezers, it is easy for the organs to slip and retract during the operation, thereby blocking the surgical field of view, and increasing the difficulty of the operation. If the fixation is performed by increasing the area of the surgical incision, the fixation effect is not only poor, but also easy to increase the risk of infection in mice, and increase the inflammatory response while affecting the experimental results.
  • peripheral organ fixation devices such as the invention of Chinese patent publication number CN108784881A, which proposes a supporting system for mouse kidney in vivo microscopic imaging and tracing, the core components of which can also play the role of peripheral organ fixation, but the system only fixes the kidneys and lacks application scenarios for other organs; and the horizontal axis distance of the system bracket cannot be changed, so it cannot fix the organs of mice of different sizes and other experimental animal strains such as rats and wild mice.
  • the size of the observation ring of the system cannot be changed, so it is impossible to perform experimental operations on different types of organs.
  • the pivot arm of the existing fixation device is not flexible enough and can only fix peripheral organs from one direction. It is also unable to change the lateral distance between the fixation device and the organ, and is unable to take into account different surgical situations and organ placement situations. Moreover, this type of fixation device only fixes a specific organ and cannot take into account most peripheral organs.
  • the use of the existing fixation device has limitations.
  • One purpose of the present application is to provide an animal organ fixation device, which can adjust its fixation range according to the size of the target organ, has high flexibility, a wide range of applications and is easy to operate, and can achieve a good organ fixation effect.
  • the present application provides an animal organ fixing device, comprising:
  • a fixture support seat comprising a base, a support rod disposed on the base, and a rocker arm rotatably connected to the support rod;
  • organ fixer comprising a retractable lower support rotatably connected to the rocker arm, a retractable clamping buckle, and a retractable middle rod connecting the retractable lower support and the retractable clamping buckle;
  • the rocker arm is used to adjust the position and posture of the organ fixator;
  • the retractable lower support is configured to be retractable in the horizontal direction
  • the retractable middle rod is configured to be retractable in the vertical direction
  • the retractable clamping buckle is configured to be retractable in the horizontal direction and has a right-angle hook, wherein the fixing range of the organ fixator can be adjusted according to the size of the target organ through the telescopic adjustment cooperation between the retractable lower support, the retractable middle rod and the retractable clamping buckle.
  • the rocker arm includes a first rocker arm rotatably connected to the support rod via a first bearing and a second rocker arm rotatably connected to the first rocker arm via a second bearing.
  • a mounting groove is provided at the end of the second rocker arm, and the retractable lower support is provided with a mounting plate with a mounting hole.
  • the mounting plate is installed in the mounting groove through a fixing member, thereby forming a state in which the retractable lower support is rotatably connected to the second rocker arm with the fixing member as a rotating axis.
  • the retractable lower support includes two first fixed shells arranged in parallel and two first telescopic rods respectively connected to the two ends of the two first fixed shells, wherein the two first telescopic rods are arranged to be able to telescopically move relative to each other in a horizontal direction from the two ends of the first fixed shells.
  • the first rocker arm and the second rocker arm are cubic structures or cylindrical structures; and the two first telescopic rods are U-shaped structures.
  • the mounting plate is disposed on any one of the first fixing shells.
  • the telescopic middle rod includes two second fixed shells arranged in parallel in the vertical direction and two second telescopic rods respectively telescopically arranged in the corresponding second fixed shells, wherein the two second telescopic rods are configured to be able to telescopically move in the vertical direction.
  • two ends of the second fixed shell of the telescopic middle rod are respectively connected to the third fixed shell and the second telescopic rod, and two ends of the second telescopic rod are respectively connected to the second fixed shell and the first fixed shell.
  • the retractable clamping buckle includes a third fixed shell arranged in the horizontal direction and two right-angle hooks retractably arranged at both ends of the third fixed shell, and the two right-angle hooks are arranged to be able to retract and move relative to each other in the horizontal direction from both ends of the third fixed shell.
  • the right-angle hook includes a first horizontal section telescopically connected to the third fixed shell, a second horizontal section vertically extending from the first horizontal section, and a vertical section vertically extending from the second horizontal section.
  • the rocker arm of the animal organ fixation device of the present application is configured as a two-stage or multi-stage rotatable structure, and the angle and position of the organ fixer can be adjusted by rotating the rocker arm, thereby adjusting the relative position between the organ fixer and the base to meet different surgical conditions and organ placement conditions.
  • the animal organ fixation device can adjust the size of the fixing range in the horizontal and vertical directions through the telescopic adjustment cooperation between the retractable lower support, the retractable middle rod and the retractable clamping buckle, thereby adjusting the fixing range of the organ fixer according to the size of the target organ.
  • the present application provides an animal organ fixation device that is highly flexible, has a wide range of applications, is easy to operate, and can achieve a good organ fixation effect.
  • FIG1 is a schematic diagram of the three-dimensional structure of the animal organ fixing device according to a preferred embodiment of the present application.
  • FIG. 2 is a schematic diagram of the three-dimensional structure of the rocker arm of the animal organ fixing device shown in FIG. 1 .
  • FIG. 3 is a schematic top view of the retractable lower support of the animal organ fixing device shown in FIG. 1 .
  • FIG. 4 is a front view schematic diagram of the retractable middle rod of the animal organ fixing device shown in FIG. 1 .
  • FIG. 5 is a schematic diagram of the three-dimensional structure of the organ fixer of the animal organ fixation device shown in FIG. 1 .
  • Animal organ fixing device 100 fixer support seat 10; base 11; support rod 12; rocker arm 13; first bearing 131; first rocker arm 132; second bearing 133; second rocker arm 134; mounting groove 135; organ fixer 20; telescopic lower support 21; mounting plate 211; mounting hole 212; first fixing shell 213; first telescopic rod 214; telescopic clamping buckle 22; third fixing shell 221; right-angle hook buckle 222; first horizontal section 2221; second horizontal section 2222; vertical section 2223; telescopic middle rod 23; second fixing shell 231; second telescopic rod 232; fixing piece 30.
  • one should be understood as “at least one” or “one or more”, that is, in one embodiment, the number of an element may be one, while in another embodiment, the number of the element may be multiple, and the term “one” should not be understood as a limitation on the quantity.
  • the terms “installed”, “connected”, and “connected” should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection, or mutual communication; it can be a direct connection, or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements.
  • installed should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection, or mutual communication; it can be a direct connection, or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements.
  • this application designs an animal organ fixation device, which can be used in peripheral organ surgery to solve the problem of organ peristalsis and retraction blocking the surgical field of view during surgery. It can also be used for peripheral organ imaging, including but not limited to two-photon imaging, in vivo fluorescence microscopy, etc.
  • the present application provides an animal organ fixation device that is simple to operate, highly flexible, and easy to operate.
  • the animal organ fixation device can stably fix peripheral organs during surgery or experiments to avoid narrowing of the surgical surface, changes in the surgical field of view, changes in the imaging surface, etc. due to breathing and the retraction of the organs themselves.
  • the present application innovatively uses a retractable fixing clamp to clamp the peripheral organs, so that the present application can be used on a variety of peripheral organs of different sizes.
  • FIG. 1 to FIG. 5 the specific structure of the animal organ fixing device 100 according to a preferred embodiment of the present application is explained.
  • the animal organ fixing device 100 includes a fixer support seat 10 and an organ fixer 20 arranged on the fixer support seat, wherein the fixer support seat 10 includes a base 11, a support rod 12 arranged on the base 11, and a rocker arm 13 rotatably connected to the support rod 12; the organ fixer 20 includes a retractable lower support 21 rotatably connected to the rocker arm 13, a retractable clamping buckle 22, and a retractable middle rod 23 connecting the retractable lower support 21 and the retractable clamping buckle 22.
  • the rocker arm 13 is used to adjust the position and posture of the organ fixator 20;
  • the retractable lower support 21 is configured to be retractable in the horizontal direction
  • the retractable middle rod 23 is configured to be retractable in the vertical direction
  • the retractable clamping buckle 22 is configured to be retractable in the horizontal direction and has a right-angle hook buckle 222, wherein the fixing range of the organ fixator 20 can be adjusted according to the size of the target organ through the telescopic adjustment cooperation between the retractable lower support 21, the retractable middle rod 23 and the retractable clamping buckle 22.
  • the horizontal direction is a direction parallel to the base 11
  • the vertical direction is a direction perpendicular to the base 11 .
  • the rocker arm 13 includes a first rocker arm 132 rotatably connected to the support rod 12 via a first bearing 131 and a second rocker arm 134 rotatably connected to the first rocker arm 132 via a second bearing 133 .
  • the height of the organ fixer 20 relative to the base 11 and the lateral distance relative to the support rod 12 can be adjusted.
  • the present application connects the rocker arm 13 and the support rod 12 through a bearing, and connects the first rocker arm 132 and the second rocker arm 134 of the rocker arm 13 through a bearing, so that the rocker arm 13 can freely move and adjust the direction and angle of the organ fixer 20, and freely adjust the lateral distance between the organ fixer 20 and the support rod 12, which can meet the placement of different organs to better adapt to a variety of experimental environments and surgical conditions.
  • the rocker arm 13 is a two-stage rotatable structure.
  • a rocker arm structure with more stages can be provided according to actual needs, and the present application does not impose any limitation on this.
  • a mounting groove 135 is provided at the end of the second rocker arm 134, and the retractable lower support 21 is provided with a mounting plate 211 having a mounting hole 212, and the mounting plate 211 is installed in the mounting groove 135 through a fixing member 30, thereby forming a state in which the retractable lower support 21 is rotatably connected to the second rocker arm 134 with the fixing member 30 as a rotating axis.
  • first rocker arm 132 and the second rocker arm 134 are cubic structures or cylindrical structures, and the present application does not limit the specific shape of the rocker arm 13 .
  • the fixing member 30 is a screw
  • the mounting hole 212 of the mounting plate 211 is a threaded hole
  • the retractable lower support 21 can rotate in a direction parallel to the base 11 with the fixing member 30 as a rotation axis, thereby adjusting the horizontal position of the organ fixer 20.
  • the rotation of the retractable lower support 21 relative to the second rocker arm 134 is a swing in the horizontal direction, that is, the retractable lower support 21 is parallel to the base 11 along the rotation plane of the fixing member 30.
  • the retractable lower support 21 includes two first fixed shells 213 arranged in parallel and two first telescopic rods 214 respectively connected to the two ends of the first fixed shells 213, wherein the two first telescopic rods 214 are configured to be able to telescopically move relative to each other in the horizontal direction from the two ends of the first fixed shells 213.
  • the two first telescopic rods 214 are in a U-shaped structure. Through the relative movement of the two first telescopic rods 214, the overall length of the telescopic lower support 21 can be adjusted, thereby adjusting the fixing range of the organ fixer 20 in the horizontal direction.
  • the mounting plate 211 is disposed on any one of the first fixing shells 213 .
  • the retractable middle rod 23 includes two second fixed shells 231 arranged in parallel in the vertical direction and two second retractable rods 232 respectively retractably arranged in the corresponding second fixed shells 231 , wherein the two second retractable rods 232 are arranged to be able to telescopically move in the vertical direction.
  • the distance between the telescopic lower support 21 and the telescopic clamping buckle 22 can be adjusted, that is, the fixing height of the organ fixer 20 can be adjusted, that is, the fixing range of the organ fixer 20 in the vertical direction can be adjusted.
  • the fixing pressure of the organ fixer 20 on the organ can be conveniently adjusted.
  • the two ends of the second fixed shell 231 of the telescopic middle rod 23 are respectively connected to the third fixed shell 221 and the second telescopic rod 232, and the two ends of the second telescopic rod 232 are respectively connected to the second fixed shell 231 and the first fixed shell 213.
  • the retractable clamping buckle 22 includes a third fixed shell 221 arranged in the horizontal direction and two right-angle hook buckles 222 retractably arranged at both ends of the third fixed shell 221, and the two right-angle hook buckles 222 are arranged to be able to retract and move relative to each other in the horizontal direction from both ends of the third fixed shell 221.
  • the right-angle hook 222 includes a first horizontal section 2221 telescopically connected to the third fixing shell 221 , a second horizontal section 2222 vertically extending from the first horizontal section 2221 , and a vertical section 2223 vertically extending from the second horizontal section 2222 .
  • the right-angle hook 222 since the right-angle hook 222 includes a horizontal section and a vertical section 2223, when the first horizontal section 2221 telescopes relative to the third fixed shell 221, it will also drive the second horizontal section 2222 and the vertical section 2223 to move, thereby adjusting the fixing range of the organ fixer 20 in two directions at the same time, so that the animal organ fixation device 100 can be used on a variety of peripheral organs of different sizes.
  • the retractable lower support 21 can adjust the horizontal position and the fixing range in the horizontal direction of the organ fixer 20
  • the retractable middle rod 23 can adjust the fixing range in the vertical direction
  • the retractable clamping buckle 22 can adjust the fixing range of the organ fixer 20 in the horizontal and vertical directions. Therefore, through the telescopic adjustment cooperation between the retractable lower support 21, the retractable middle rod 23 and the retractable clamping buckle 22, the fixing range of the organ fixer 20 can be adjusted according to the size of the target organ.
  • the animal organ fixation device 100 of the present application can be applied to the fixation of the organs of mice, rats, wild mice, rabbits, monkeys and other animals, and the present application does not specifically limit the applicable animal types.
  • the organ fixator 20 can be changed from horizontal fixation to vertical fixation; according to the requirements of the experimental operation on the organ, the pressure of the organ fixator 20 on the organ can be adjusted by adjusting the length of the retractable middle rod 23 of the organ fixator 20.
  • the animal organ fixation device 100 of the present application can also be used in conjunction with other instruments and experimental devices such as fine scissors and fine tweezers can be added to the organ fixer 20 to achieve the purpose of performing experimental operations on mouse organs directly through the animal organ fixation device 100, and the present application does not impose any restrictions on this.
  • the animal organ fixation device 100 of the present application has been proven to be feasible through experimental operations.
  • the experimenter used the animal organ fixation device 100 of the present application to fix the kidneys and intestines of 3 C57BL6/J mice during surgery, and found that there was no organ peristalsis and retraction during the 1-hour surgery, which proved that it had a good fixation effect.
  • the present application can freely move the direction of the fixture and the lateral distance from the bracket to the mouse organ through the bearing connection, which can better adapt to various experimental environments;
  • the organ fixator 20 of the present application is composed of a telescopic rod, and the size of the fixing space of the fixator can be changed by telescopic adjustment, so it can be adapted to organs of different sizes and types, and has a wider applicability;
  • This application can flexibly adjust the numerical values for different types of experimental animals and different experimental designs, and has a wider range of applications.
  • the rocker arm 13 of the animal organ fixation device 100 is set as a two-stage or multi-stage rotatable structure, and the angle and position of the organ fixer 20 can be adjusted by rotating the rocker arm 13, thereby adjusting the relative position between the organ fixer 20 and the base 11 to meet different surgical conditions and organ placement conditions.
  • the animal organ fixation device 100 can adjust the size of the fixing range in the horizontal and vertical directions through the telescopic adjustment cooperation between the telescopic lower support 21, the telescopic middle rod 23 and the telescopic clamping buckle 22, so that the fixing range of the organ fixer 20 can be adjusted according to the size of the target organ.
  • the present application provides an animal organ fixation device 100 which has high flexibility, a wide range of applications, is easy to operate, and can achieve a good organ fixation effect.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Animal Husbandry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Surgical Instruments (AREA)

Abstract

La présente invention concerne un dispositif de fixation de viscères d'animaux (100), comprenant une base de support de fixateur (10) et un fixateur de viscères (20) disposé sur la base de support de fixateur (10). La base de support de fixateur (10) comprend une base (11), une tige de support (12) disposée sur la base (11), et un culbuteur (13) relié de manière rotative à la tige de support (12). Le fixateur de viscères (20) comprend un support inférieur télescopique (21) relié de manière rotative au culbuteur (13), une boucle de serrage télescopique (22) et une tige centrale télescopique (23) reliée au support inférieur télescopique (21) et à la boucle de serrage télescopique (22). L'angle et la position du fixateur de viscères (20) sont ajustés par rotation du culbuteur (13), de telle sorte que les exigences liées à différentes conditions de manipulation et de positionnement des viscères peuvent être satisfaites. Au moyen d'une coopération d'ajustement télescopique entre le support inférieur télescopique (21), la tige centrale télescopique (23) et la boucle de serrage télescopique (22), la taille d'une plage de fixation peut être ajustée dans une direction horizontale et une direction verticale, de telle sorte que la plage de fixation du fixateur de viscères (20) peut être ajustée en fonction de la taille d'un organe viscéral cible.
PCT/CN2022/133122 2022-11-21 2022-11-21 Dispositif de fixation de viscères d'animaux Ceased WO2024108325A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2022/133122 WO2024108325A1 (fr) 2022-11-21 2022-11-21 Dispositif de fixation de viscères d'animaux

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2022/133122 WO2024108325A1 (fr) 2022-11-21 2022-11-21 Dispositif de fixation de viscères d'animaux

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WO2024108325A1 true WO2024108325A1 (fr) 2024-05-30

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119700026A (zh) * 2024-12-20 2025-03-28 中国科学技术大学 一种适用于动物脾脏的光学活体成像装置及方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070038115A1 (en) * 2005-08-12 2007-02-15 Quigley David P High intensity ultrasound apparatus methods and systems
CN106859714A (zh) * 2017-04-13 2017-06-20 中国人民解放军总医院 一种可释放回收的腹腔镜下脏器托举囊
CN210990891U (zh) * 2019-08-14 2020-07-14 于慧 一种初生大鼠心脏采集的固定装置
CN212521925U (zh) * 2020-01-15 2021-02-12 山东大学齐鲁医院 一种用于腹部微创手术的器官支撑与固定器械
CN212574939U (zh) * 2020-04-08 2021-02-23 常州市第一人民医院 一种甲状腺细针穿刺固定装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070038115A1 (en) * 2005-08-12 2007-02-15 Quigley David P High intensity ultrasound apparatus methods and systems
CN106859714A (zh) * 2017-04-13 2017-06-20 中国人民解放军总医院 一种可释放回收的腹腔镜下脏器托举囊
CN210990891U (zh) * 2019-08-14 2020-07-14 于慧 一种初生大鼠心脏采集的固定装置
CN212521925U (zh) * 2020-01-15 2021-02-12 山东大学齐鲁医院 一种用于腹部微创手术的器官支撑与固定器械
CN212574939U (zh) * 2020-04-08 2021-02-23 常州市第一人民医院 一种甲状腺细针穿刺固定装置

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119700026A (zh) * 2024-12-20 2025-03-28 中国科学技术大学 一种适用于动物脾脏的光学活体成像装置及方法

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