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WO2024100117A1 - Dispositif d'éclairage et dispositif de formation d'images doté d'un dispositif d'éclairage - Google Patents

Dispositif d'éclairage et dispositif de formation d'images doté d'un dispositif d'éclairage Download PDF

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Publication number
WO2024100117A1
WO2024100117A1 PCT/EP2023/081155 EP2023081155W WO2024100117A1 WO 2024100117 A1 WO2024100117 A1 WO 2024100117A1 EP 2023081155 W EP2023081155 W EP 2023081155W WO 2024100117 A1 WO2024100117 A1 WO 2024100117A1
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WO
WIPO (PCT)
Prior art keywords
light
illumination
imaging
lighting
guide element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2023/081155
Other languages
German (de)
English (en)
Inventor
Bernhard Glöggler
Thomas Hinding
Uwe Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Karl Storz SE and Co KG
Original Assignee
Karl Storz SE and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karl Storz SE and Co KG filed Critical Karl Storz SE and Co KG
Publication of WO2024100117A1 publication Critical patent/WO2024100117A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0661—Endoscope light sources
    • A61B1/0669—Endoscope light sources at proximal end of an endoscope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0638—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0661—Endoscope light sources
    • A61B1/0684—Endoscope light sources using light emitting diodes [LED]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/07—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2461—Illumination
    • G02B23/2469—Illumination using optical fibres
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B19/00—Condensers, e.g. light collectors or similar non-imaging optics
    • G02B19/0033—Condensers, e.g. light collectors or similar non-imaging optics characterised by the use
    • G02B19/0095—Condensers, e.g. light collectors or similar non-imaging optics characterised by the use for use with ultraviolet radiation
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/10—Beam splitting or combining systems
    • G02B27/14—Beam splitting or combining systems operating by reflection only
    • G02B27/149—Beam splitting or combining systems operating by reflection only using crossed beamsplitting surfaces, e.g. cross-dichroic cubes or X-cubes

Definitions

  • the invention relates to an illumination device and an imaging device with an illumination device.
  • Imaging devices such as endoscopic or exoscopic devices are known from the prior art. These have lighting devices by means of which lighting light can be generated that illuminates an object to be imaged when an image is taken. Lighting devices of this type are often designed separately from an imaging instrument such as an endoscope and are connected by means of suitable optical elements. Lighting light can then be fed through the imaging instrument to the object to be imaged.
  • Such imaging devices can be set up to record fluorescence images.
  • the object to be imaged is illuminated with light of a first wavelength or in a first spectral range.
  • Light emitted by the object is then detected, often by specifically introduced dyes that can be excited to fluorescence.
  • This emitted light has a second wavelength or is in a second spectral range, whereby the emitted light is shifted to longer wavelengths relative to the illumination light.
  • observation filters are used that have a filter edge below which they are opaque. The excitation light can be blocked in this way, whereby only the fluorescent light shifted to longer wavelengths is observable.
  • observation filters are chosen so that a small remainder of the excitation light can pass through the observation filter.
  • the filter edge is chosen such that it lies in a region of a long-wave descending edge of an excitation spectrum and a slight overlap is formed.
  • the light that comes from the region of this overlap can be used as background light that is remitted by the object to be imaged.
  • the remitted background light can then be used alternatively or in parallel to the emitted fluorescent light can be observed.
  • the background light is used, for example, to be able to observe the object to be imaged, even if it has areas that do not fluoresce. For example, this can enable a user to orient themselves, identify tissue to be imaged or differentiate malignant tissue, for example.
  • the area of this overlap is at the blue end of the observed spectral range and thus also at the blue end of the observed spectrum. This is also due to the fact that the fluorescent dyes used regularly show a significant red shift. The fluorescent light therefore appears in the red relative to the area of the overlap.
  • the small proportion of the excitation light that can pass through the observation filter is often referred to as "blue tongue".
  • the light of the blue tongue is in the blue spectral range for many of the dyes used. However, depending on the dye used, both the absorption spectra and the emission spectra can vary.
  • the background light is then not necessarily located in the blue spectral range, but only generally at shorter wavelengths than the fluorescent light.
  • the term "blue tongue” therefore only refers as an example to the case where the background light is in the blue spectral range.
  • LED-based lighting elements have been increasingly used in lighting devices, particularly white light LEDs.
  • an observation filter may not be necessary because the spectrum of the LED used as the excitation source does not extend into the spectral range in which fluorescent light is emitted.
  • LEDs are sometimes provided with excitation filters.
  • high-intensity LEDs used for imaging are often still very intense even with a minimal nominal power supply, which means that the background light generated can overshadow the fluorescence image.
  • attenuation filters that can be mechanically inserted in front of the LED in question are therefore used to generate background light with the desired low intensity.
  • multispectral or hyperspectral images have a spectral dimension.
  • the spectral dimension includes several spectral bands (wavelength bands).
  • Multispectral and hyperspectral images differ essentially in the number and width of their spectral bands.
  • DE 20 2014 010 558 U1 describes a device for recording a hyperspectral image of an examination area of a body.
  • the device has an input lens for generating an image in an image plane and a slit-shaped aperture in the image plane for masking out a slit-shaped area of the image.
  • the light passing through the aperture is fanned out by a dispersive element and recorded by a camera sensor.
  • the camera sensor can record a large number of spectra, each with an associated spatial coordinate, along the longitudinal direction of the slit-shaped aperture.
  • the device described is also designed to record further spectra along the longitudinal direction of the slit-shaped aperture in a direction different from the longitudinal direction of the slit-shaped aperture.
  • the method for generating multispectral or hyperspectral images on which this disclosure is based is also known as the so-called pushbroom method.
  • whiskbroom method the area of investigation or object is scanned point by point and a spectrum is obtained for each point.
  • staring method several images are taken with the same spatial coordinates. Different spectral filters and/or illumination sources are used from image to image to resolve spectral information.
  • a two-dimensional multi-colour image is broken down into several individual spectral images using suitable optical elements such as optical slicers, lenses and prisms, which are simultaneously displayed on different detectors or detector areas. This is sometimes referred to as a snapshot approach.
  • multispectral and hyperspectral imaging devices are particularly suitable as endoscopic imaging devices.
  • multispectral and/or hyperspectral imaging is a fundamental field of application, for example for diagnostics and for assessing the success or quality of an intervention.
  • white light imaging is used, particularly in the medical imaging field. Observed tissue is illuminated with white light, and images of the tissue are generated using a camera or other image capture sensor, which can then be displayed to a user.
  • multimodal imaging devices are multimodal endoscopes and multimodal exoscopes.
  • light sources may be required that can be operated in different illumination modes in order to generate illumination light in different spectral ranges as required.
  • Switchable or interchangeable optical components may also be required to adapt the imaging device to the different modes. If at least one fluorescence mode is to be implemented, a blue tongue should be present, as explained above, in order to make the imaging device easy to handle and use in a targeted manner.
  • the invention is based on the object of providing a lighting device with a reliable structure by means of which a controlled background lighting is possible.
  • an illumination device an imaging device, a method for generating illumination light and a method for operating an imaging device as described herein and defined in the claims.
  • a lighting device can be provided in particular for providing illumination light for a medical imaging instrument such as an endoscope, exoscope and/or microscope.
  • the lighting device comprises an optical interface for optically connecting an imaging instrument and a lighting unit which is designed to supply illumination light to the optical interface by means of which an object to be imaged can be illuminated during imaging, and which is further configured to supply background light to the optical interface by means of which the object to be imaged can be illuminated for preparation and/or assessment of the imaging.
  • the lighting unit comprises at least one lighting element which is configured to generate the illumination light.
  • the lighting unit comprises at least one surface radiator which is configured to generate the background light and to emit it over a surface
  • the surface radiator comprises a light source and a light guide element, wherein the light guide element defines an emission direction for the background light, and wherein light generated by the light source can be coupled laterally into the light guide element with respect to the emission direction.
  • an imaging device can be provided, in particular a medical imaging device, which comprises an illumination device according to the invention and an imaging instrument, for example an endoscope and/or exoscope and/or microscope, which can be connected to the optical interface of the illumination device.
  • an imaging instrument for example an endoscope and/or exoscope and/or microscope, which can be connected to the optical interface of the illumination device.
  • a method for generating illumination light for an imaging instrument can be provided, wherein the illumination light is generated by means of an illumination device according to the invention.
  • an imaging device which comprises an imaging instrument.
  • Illumination light generated according to a method according to the invention for generating illumination light is supplied to the imaging instrument.
  • the features according to the invention make it possible to provide a lighting device by means of which background light can be generated in a simple and controlled manner.
  • a high degree of structural compactness and/or simplicity can be achieved.
  • movable components can be dispensed with in connection with the generation of background light. This makes it possible to switch between different modes, such as switching the background light on and off, by simply switching the light source that is assigned to the surface radiator.
  • This makes very high frequencies possible, and For example, imaging can be carried out in which frames with and without background light are recorded alternately or at specific intervals.
  • an intensity and/or a wavelength of the light used for the background lighting can be selected specifically and independently of the light element that provides the illumination light.
  • the imaging device can be a microscopic, macroscopic and/or exoscopic imaging device.
  • the imaging instrument can be designed as a microscope, macroscope and/or exoscope and/or can comprise such a device.
  • the imaging device can be an endoscopic imaging device, in particular an endoscope device.
  • the imaging instrument can be and/or can comprise an endoscope. It is understood that the imaging instrument can have electronic components but can also be designed to be purely mechanical/optical.
  • the imaging device and in particular the imaging instrument is designed to be insertable into a cavity for assessment and/or observation, for example into an artificial and/or natural cavity, such as into the interior of a body, into a body organ, into tissue or the like.
  • the imaging device and in particular the imaging instrument can also be designed to be insertable into a housing, a casing, a shaft, a pipe or another, in particular artificial, structure for assessment and/or observation.
  • the imaging device and in particular the imaging instrument can be configured to record tissue parameters, images of wounds, images of body parts, etc.
  • the imaging device can be configured to image a surgical field.
  • the imaging device and/or the imaging instrument comprises an image capture unit.
  • the image capture unit can be configured for fluorescence imaging.
  • the image capture unit can comprise at least one optical system and at least one image capture sensor coupled to the optical system.
  • the image capture unit can comprise at least one excitation filter and/or at least one observation filter.
  • the excitation filter can be arranged in front of the light element and, together with a spectrum of the light element, define a spectrum of the illumination light.
  • the observation filter can be configured to capture light below a Cutoff wavelength to attenuate and/or block light and to attenuate and/or transmit light above the cutoff wavelength to a lesser extent.
  • the cutoff wavelength is preferably selected such that it is at most 50 nm shorter than a largest wavelength of the spectrum of the illumination light.
  • the spectrum of the illumination light and a passband of the observation filter can be disjoint from one another, wherein in particular the passband with respect to the spectrum of the illumination light lies at longer wavelengths.
  • Multiple observation filters and/or excitation filters and/or light elements with different spectra can be used. In this way, an excitation spectrum and/or an observable spectrum can be adapted to an absorption spectrum and/or an emission spectrum of a fluorescent dye used.
  • the imaging device and/or the image acquisition unit can be configured for spectrally resolved imaging and/or white light imaging in addition to or as an alternative to fluorescence imaging.
  • Fluorescence imaging, white light imaging and/or spectrally resolved imaging can be carried out simultaneously or alternately or at times simultaneously and at times one after the other. Separate optics and/or common optics can be used for this purpose.
  • the image capture unit can have spatial and spectral resolution. This should be understood in particular to mean that the image capture unit is set up to carry out an image capture of the object to be imaged, in which spatially and spectrally resolved image data are generated that include both spatial and spectral information.
  • the image capture unit and in particular the optics and/or the image capture sensor system can be set up for multispectral and/or hyperspectral imaging, in particular for capturing and/or generating multispectral and/or hyperspectral image data.
  • Multispectral imaging or multispectral image data can refer in particular to such imaging in which at least two, in particular at least three, and in some cases at least five spectral bands can be and/or are captured independently of one another.
  • Hyperspectral imaging or hyperspectral image data can refer in particular to such imaging in which at least 20, at least 50 or even at least 100 spectral bands are and/or can be detected independently of one another.
  • the imaging device can operate according to the pushbroom method and/or the whiskbroom method and/or the staring method and/or a snapshot principle.
  • the imaging device and/or the image capture unit comprises a white light camera and/or sensors for white light image capture. Separate optics and/or common optics can be used for white light imaging.
  • Hyperspectral imaging is then a good option.
  • This can be combined with white light imaging and/or fluorescence imaging. This enables real-time observation via a white light image and/or a fluorescence image, even if the acquisition of spectrally resolved image data only takes place essentially in real time, i.e. several seconds are needed to create a spectrally resolved image.
  • spectral image data in real time. This includes, for example, generating a spectrally resolved image in less than a second or even several times per second. In this case, it may be useful to use multispectral imaging. A possibly lower spectral resolution is then offset by a higher frame rate. Depending on the application, it may be sufficient to consider only a few different spectral ranges and/or wavelengths, for example two or three or four or generally less than ten. In this case, additional white light imaging can optionally be dispensed with. Spectrally resolved image data that is acquired in real time or provides several images per second can also be used for surveillance purposes, whereby an image for a user to display does not necessarily have to be created, but the image data can also be processed in the background.
  • the optical interface can be either detachable or connectable.
  • the optical interface can be combined with a mechanical interface so that an optical connection is automatically established, for example, when the imaging instrument is mechanically coupled.
  • the at least one light element can comprise an LED and/or be designed as such.
  • the light element can be part of a light unit that comprises multiple light elements. In this case, different light elements can be provided that emit in different spectral ranges.
  • the light unit can comprise one or more narrow-band emitting and/or single-color light elements.
  • the light unit can additionally comprise at least one white light element that emits in a broadband manner. In particular, the white light element can largely or completely cover a visible spectral range.
  • the white light element can be designed to emit at least in a range between 480 nm and 650 nm, preferably at least in a range between 450 nm and 680 nm, and particularly preferably at least in a range between 430 nm and 700 nm.
  • the lighting device can comprise a controller that is designed to control the at least one lighting element and the light source for the surface radiator.
  • the controller can be designed to control the lighting unit and optionally activate, deactivate and/or adjust the intensity of one or more of the existing lighting elements.
  • the illumination light is used to capture fluorescence images.
  • the background light can also be available before, during and/or after the capture of fluorescence images in order to observe the object to be imaged by reflecting the background light off the object to be imaged. A user can thus assess the object to be imaged through the background light and also examine areas of the object that do not contain a fluorescent dye.
  • Light from the light source, which is coupled laterally into the light guide element, can be radiated onto the light guide element in a direction which forms an angle with the direction of emission which is at least 45 degrees, preferably at least 60 degrees, preferably at least 75 degrees and particularly preferably at least 85 degrees and/or at most 135 degrees, preferably at most 120 degrees, preferably at most 105 degrees and particularly preferably at most 95 degrees.
  • the direction in which the light from the light source is radiated onto the light guide element can be perpendicular to the direction of emission.
  • Light can be emitted from several sides and/or from several directions into the light guide element. The angle relationships mentioned can still apply. If different beam directions are used, these are preferably directed towards the center of the light guide element.
  • the light guide element comprises in particular at least one coupling edge into which the light from the light source can be coupled.
  • the light guide element can have an edge opposite the coupling edge, at which the light guide element is bevelled. This bevelling can cause a directed coupling out of the incident light from the light source.
  • the light guide element can comprise at least one emission surface from which the background light is coupled out.
  • the light guide element can comprise a base body that defines the coupling edge and/or the emission surface.
  • the light guide element can comprise coupling-out structures and/or scattering centers that are designed to couple light from the light source that is coupled into the light guide element out of the emission surface.
  • the base body of the light guide element can be a light guide plate and/or a light guide film.
  • the surface radiator and/or the light guide element can be designed, for example, as described in DE 10 2010 019 051 A1 and/or WO 2011/131429 A1.
  • the light guide element can be designed to emit the background light in a directed manner. This can include the primary or at least substantially exclusive coupling out of light from a single emission surface. Alternatively or additionally, this can include the light guide element being designed to at least partially focussed and/or non-parallel coupling out of the background light.
  • scattering centers and/or coupling-out structures of the light guide element are distributed anisotropically and/or differently oriented. Background light that is emitted from a center of the light guide element is then emitted vertically, for example, whereas light that is emitted from the edge of the light guide element is emitted at an angle towards the center.
  • the light guide element can emit partially diffusely and partially directed, wherein the partially directed emission can be directed at a focal point and/or a focal area and/or a focal line.
  • scattering centers and/or coupling-out structures of the optical fiber element can be distributed anisotropically.
  • a more density of scattering centers and/or coupling-out structures can be achieved in this way.
  • the light source can comprise at least one LED and/or a light bar and/or an LED bar and/or an LED array.
  • the light source can extend along the coupling edge of the light guide element.
  • the light source and the light guide element are preferably immobile and/or stationary relative to one another.
  • a high degree of versatility with regard to possible arrangements of optical components can be achieved in particular when the light guide element is designed to be translucent, with the lighting element being arranged in such a way that the illumination light passes through the light guide element.
  • the illumination light and the background light can thus be emitted in a manner as if they were essentially coming from the same light source.
  • the surface radiator can in particular be arranged in front of the lighting element.
  • the illumination light and the background light can be coupled into the same optical path that leads to the optical interface.
  • the lighting element defines a direction of radiation for the illumination light, wherein the direction of radiation for the illumination light and the direction of radiation for the background light are oriented essentially parallel to one another.
  • This makes it possible to simulate the behavior of a conventional light source in which, for example, a blue tongue can be generated using suitable filters.
  • This can include arrangements in which the illumination light passes through the light guide element.
  • this can include arrangements in which the surface radiator is arranged next to the lighting element and/or laterally offset with respect to the lighting element.
  • the lighting unit comprises an optical element that serves to focus and/or refract and/or collimate and/or deflect the illumination light, wherein the light guide element is formed integrally with the optical element.
  • the optical element can be a mirror, a beam splitter, a beam combiner and/or a lens.
  • the light guide element can form the optical element.
  • the optical element can be the light guide element.
  • the optical Element may be provided with scattering centers and/or coupling-out structures and have a coupling edge into which the light from the light source can be coupled laterally, while the optical element simultaneously fulfils its function of focusing and/or deflecting the illumination light.
  • the lighting unit comprises a holder for the optical element, wherein the light source is integrated into the holder.
  • the holder can be used to arrange and/or hold a beam combiner and/or a lens in front of the lighting element. It is particularly expedient in this context if the light guide element is formed integrally with the optical element. The light from the light source, which is integrated into the holder, can then be coupled directly and efficiently into the light guide element.
  • a high frequency for switching between operating modes can be achieved in particular if the lighting unit is set up to selectively switch the background light on and off independently of the illumination light by selectively switching the light source on and off.
  • the surface radiator can be designed without mechanically movable components.
  • the background light can then be switched on and off directly by switching the light source on and off.
  • the lighting device can be set up to switch the background light on and off frame by frame.
  • “Frame by frame” can mean that a certain first number of images with background lighting and a certain second number of images without background lighting can be recorded alternately, wherein the first number and/or the second number can be 1 or greater than 1, and wherein the first number and the second number can be the same or different.
  • a light intensity of the illumination light can be greater than a light intensity of the background light, in particular at least 2 times, at least 5 times, at least 10 times, at least 50 times or at least 100 times greater. This makes it possible to provide background light with a suitable intensity that allows fluorescence imaging to be carried out without a fluorescence image being outshone by the background light.
  • the devices according to the invention and the methods according to the invention should not be limited to the application and embodiment described above. In particular, in order to fulfill a function described herein, they can have a number of individual elements, components and units as well as method steps that differs from the number stated herein. In addition, in the value ranges specified in this disclosure, values within the stated limits should also be considered disclosed and can be used as desired.
  • first, second, third object, etc. these serve to name and/or assign objects. Accordingly, for example, a first object and a third object, but not a second object, can be included. However, a number and/or sequence of objects could also be derived using numerical words.
  • Fig. 1 is a schematic representation of an imaging device with an illumination device
  • Fig. 2 is a schematic representation of the lighting device
  • Fig. 3 schematic transmission curves of beam splitter elements of the lighting device
  • Fig. 4 is a schematic representation of a first surface radiator that can be used in the lighting device
  • Fig. 5 is a schematic perspective view of a second surface radiator that can be used in the lighting device
  • Fig. 6 is a schematic perspective view of a third surface radiator that can be used in the lighting device
  • Fig. 7 is a schematic representation of a fourth surface radiator that can be used in the lighting device.
  • Fig. 8 is a schematic perspective view of a fifth surface radiator.
  • Fig. 1 shows a schematic representation of an imaging device 10.
  • the imaging device 10 is an endoscopic imaging device, specifically an endoscope device.
  • the imaging device 10 could be an exoscopic, a microscopic or a macroscopic imaging device.
  • the imaging device 10 is shown as an example as a medical imaging device.
  • the imaging device 10 is intended, for example, for examining a cavity.
  • the imaging device 10 has a medical imaging instrument 14. In the case shown, this is an endoscope.
  • the imaging device 10 comprises an illumination device 12 with an optical interface 16 and an illumination unit 18.
  • the imaging instrument 14 can be optically connected to the optical interface 16.
  • the optical interface 16 can be part of an optical-mechanical interface that can be optionally connected and disconnected.
  • the illumination device 14 can optionally be connected to the illumination device 12 can be decoupled.
  • the illumination unit 18 is designed to supply illumination light to the optical interface 16. When imaging using the imaging instrument 14, the illumination unit 18 can accordingly provide the required illumination light, which is guided to the illumination device 14 and from there coupled out onto an object to be imaged, such as a site.
  • the imaging instrument 14 is also connected via a line not provided with a reference symbol, via which, for example, data from a camera of the imaging instrument 14 can be transmitted.
  • the imaging device 10 further comprises a display unit on which images can be displayed that are based on image data that were captured by means of the imaging instrument 14 and that relate to an object 120 to be imaged. These can be video images, still images, overlays of different images, partial images, image sequences, etc.
  • the imaging device 10 is multimodal.
  • the imaging device can be operated in three basic modes, a fluorescence mode, a multispectral mode, and a white light mode.
  • the imaging device 10 can be operated in a hyperspectral mode in addition to or as an alternative to the multispectral mode.
  • the lighting device 12 is also multimodal in the example shown.
  • the lighting device 12 can be operated in different lighting modes in which it supplies light for different imaging modes.
  • the lighting device 12 can be operated in three basic modes, a multispectral mode, a fluorescence mode and a white light mode.
  • the imaging instrument 14 can also be operated in different operating modes, specifically also at least in a multispectral mode, a fluorescence mode and a white light mode. In the corresponding operating mode of the imaging device 10, the modes of the lighting device 12 are coordinated with one another.
  • the imaging device 10 and the illumination device may be operable in two basic modes, in a White light mode and in a fluorescence mode.
  • the background lighting described below can also be used in recording modes other than fluorescence imaging.
  • Fig. 2 shows a schematic representation of the lighting device 12.
  • the lighting unit 18 comprises, for example, a plurality of independently activatable lighting elements 20, 22, 24, 26, 28, wherein generally speaking at least one lighting element is provided and the number shown is for illustrative purposes.
  • the lighting elements 20, 22, 24, 26, 28 are designed to emit light according to different emission spectra in order to provide illumination light, i.e. the respective emission spectrum differs from lighting element to lighting element.
  • the light elements 20, 22, 24, 26, 28 are designed as LEDs.
  • a first light element 20 is designed as a red LED
  • a second light element 22 as a dark red LED
  • a third light element 24 as a blue LED
  • a fourth light element 26 as a near-IR LED.
  • the colored light elements 20, 22, 24, 26 each emit in a narrow band, for example with an emission peak at wavelengths of around 660 nm (first light element 20), 770 nm (second light element 22), 460 nm (third light element 24) and 940 nm (fourth light element 26).
  • a fifth light element 28 is provided, which in the present case is a white light element, for example a white light LED.
  • the fifth light element 28 emits, for example, in a spectral range of approximately 400 to 700 nm.
  • laser diodes can also be used, in particular colored light elements.
  • some of the lighting elements 20, 22, 24, 26, 28 are activated at least temporarily, whereas other lighting elements 20, 22, 24, 26, 28 may not be used in the lighting mode in question.
  • a first group comprises the first light element 20 and the fourth light element 26.
  • the first group can additionally comprise the light element 22 and/or the light element 24.
  • the first group is used for multispectral imaging, with the light elements 20, 26 and possibly 22 and 24 each serving as a support point.
  • multispectral mode for example, the first light element 20 is first used for illumination and an image is taken. Then is illuminated with the fourth light element 26 and an image is recorded. The images are based on remission, ie the light scattered back from the object to be imaged is observed. Spectral information about the object to be imaged can be obtained through the two different support points. For example, this can be used to assess certain types of tissue, a perfusion state, a tissue condition or the like.
  • a second group also includes the first light element 20, the second light element 22 and the third light element 24.
  • the second group is used for illumination in fluorescence imaging.
  • objects colored with suitably selected dyes can be viewed in a targeted manner. Different dyes can also be introduced into different types of tissue or the like, which are viewed at the same time.
  • By specifically exciting a certain dye it is excited to fluoresce.
  • the fluorescent light is then imaged.
  • the first light element 20 is suitable, for example, for exciting the dye cyanine 5.5 (Cy 5.5).
  • the second light element 22 is suitable for exciting the dye indocyanine green (ICG).
  • the third light element 24 is suitable for exciting the dye fluorescein.
  • a third group comprises the fifth light element 28.
  • the third group also comprises the first light element 20 and the third light element 24.
  • the third group serves to provide illumination light for white light imaging.
  • white light from the fifth light element 28 can be mixed with light from certain colored light elements, whereby spectral losses can be compensated and/or a color temperature can be set in a targeted manner.
  • some of the light elements 20, 22, 24, 26, 28 are assigned to several groups, for example the first light element 20 to all three groups and the third light element 24 and possibly also the second light element 22 to the second and third groups.
  • the imaging instrument 14 can comprise a pushbroom arrangement as a hyperspectral detector. In other embodiments, a whiskbroom arrangement, a staring arrangement and/or a snapshot arrangement is used.
  • the imaging instrument 14 can be a hyperspectral imaging instrument.
  • the lighting unit 18 comprises two crossed beam splitters 30, 32, which can also be referred to as beam combiners. These each comprise an output side 42, 44, an input side 37, 41 opposite the output side 42, 44, and two input sides 34, 36, 38, 40 opposite each other. All input sides 34, 36, 37, 38, 40, 41 guide incident light to the corresponding output side 42, 44.
  • the output side 42 of a first crossed beam splitter 30 faces an input side 41 of the second crossed beam splitter 32.
  • the output side 44 of the second crossed beam splitter 32 faces the optical interface 16.
  • the two crossed beam splitters 30, 32 are preferably arranged coaxially to each other and/or to the optical interface.
  • the lighting unit 18 can comprise suitable optical elements such as lenses and/or mirrors (not shown).
  • suitable optical elements such as lenses and/or mirrors (not shown).
  • Several lenses 78, 80, 82, 84, 86, 88 are shown as examples in Fig. 2.
  • a lens 78 is assigned to the optical interface 16 and couples light coming from the output side 44 of the second crossed beam splitter 32 into the optical interface 16.
  • a lens 80, 82, 84, 86, 88 can be assigned to each of the lighting elements 20, 22, 24, 26, 28.
  • a particularly high degree of compactness can be achieved in particular when the lighting elements 20, 22, 24, 26, 28 are each arranged on the input sides 34, 36, 37, 38, 40 of the at least one crossed beam splitter 30, 32 without an intermediate mirror.
  • the lighting elements 20, 22, 24, 26, 28 can then be moved very close to at least one crossed beam splitter 30, 32.
  • the crossed beam splitters 30, 32 each comprise two beam splitter elements 90, 92, 94, 96. These can in principle be partially transparent, so that light from all input sides 34, 36, 37, 38, 40, 41 is redirected to the respective output side 42, 44.
  • the beam splitter elements 90, 92, 94, 96 are selectively transparent. This is illustrated with further reference to Fig. 3.
  • the beam splitter elements 90, 92, 94, 96 can be filters that only reflect in a defined area, but otherwise have a high transmission. Fig.
  • FIG. 3 shows transmission curves 98, 100, 102, 104 of the beam splitter elements 90, 92, 94, 96 of the two crossed beam splitters 30, 32.
  • Each of the colored light elements 20, 22, 24, 26 or each of the opposite input sides 34, 36, 38, 40 is assigned one of the beam splitter elements 90, 92, 94, 96.
  • the beam splitter elements 90, 92, 94, 96 are selected such that they each reflect in the wavelength range in which the associated light element 20, 22, 24, 26 emits, but also largely transmit.
  • notch filters can be used in the middle wavelength range, which can have, for example, the transmission spectra 100 and 102.
  • high-pass or low-pass filters can also be used instead of notch filters, see transmission spectra 98 and 104.
  • light from the fifth light element 28 is spectrally clipped. It can therefore be expedient, in the manner already mentioned, to supplement the light blocked by the beam splitters 30, 32 in a targeted manner using the light elements 20 and 24, possibly also 22 and/or 26. This makes it possible to supplement the light specifically in those spectral ranges in which the beam splitters 30, 32 absorb and/or reflect light from the fifth light element 28, but in any case do not transmit it to the optical interface 16.
  • the additionally used light elements 20, 24 and possibly 22 are preferably operated with reduced power or with adjusted power. The aim here can be to at least largely restore the original spectrum of the fifth light element 28.
  • the fifth light element 28 can alternatively be a green light element, or generally speaking, a colored light element that emits primarily in the spectral range that the at least one beam splitter 30, 32 transmits.
  • the fifth light element 26 in such embodiments can be an LED with an emission peak at approximately 530 nm.
  • a green laser diode is also possible for this. It may be that color mixing takes place in white light mode and, in particular, no individual white light source such as a white light LED is used, but rather white light from separate light elements is specifically mixed.
  • such a green light element can also be used in fluorescence mode. Alternatively or additionally, it could be used in multispectral mode.
  • the lighting unit 18 defines a common optical path 54 into which emitted light from the lighting elements 20, 22, 24, 26, 28 can be coupled.
  • the common optical path 54 extends from the output side 44 of the second crossed beam splitter 32 to the optical interface.
  • the common optical path 54 is arranged coaxially with the fifth lighting element 26.
  • the lighting elements 20, 26 of the first group are arranged such that light emitted by the lighting elements 20, 26 travels a light path of at least substantially the same length from the respective lighting element 20, 26 to the optical interface 16.
  • the lighting elements 20, 26 of the first group each have a light-emitting surface 56, 58.
  • the light-emitting surfaces 56, 62 are arranged equidistantly with respect to the common optical path 54. In the present case, this is achieved in that the two lighting elements 20, 26 are arranged at the same distance from the beam splitter 32 assigned to them (in the present case, the second beam splitter 32 by way of example), in particular from its opposite input sides 38, 40.
  • the light is coupled into the common optical path 54 by the crossed beam splitter 32.
  • the beam splitters 30, 32 are in particular arranged such that light-emitting surfaces 56, 58, 60, 62, 64 of the lighting elements 20, 22, 24, 26, 28 are each arranged equidistantly with respect to their associated crossed beam splitter 30, 32.
  • the lighting unit 18 or the lighting device 12 has a high degree of compactness.
  • the equidistant arrangement makes it possible to ensure that no spectral shifts occur when the imaging instrument 14 or its light guide is rotated relative to the optical interface 16. It is understood that a different number of light elements 20, 22, 24, 26, 28 and/or a different number of crossed beam splitters 30, 32 may be used.
  • the use of crossed beam splitters 30, 32 has proven to be particularly useful. In other embodiments, however, other types of beam splitters and/or other optical elements may be used to couple light from the light elements 20, 22, 24, 26, 28 into the optical interface 16.
  • Fig. 4 shows a schematic representation of a first surface radiator 200 that can be used in the lighting device. As can be seen, the surface radiator 200 is arranged behind the lens 84 of the lighting element 28.
  • illumination light can be generated by means of the light element 28.
  • background light can be generated by means of the surface radiator 200.
  • the background light can be used in particular to illuminate the object to be imaged before, during or after fluorescence imaging. A user can then assess the object to be imaged and in particular also identify sections of the object that do not fluoresce, for example because no fluorescent dye has been introduced there.
  • a single such surface emitter 200 is provided.
  • the lighting elements 20, 22, 24, 26, 28 can be equipped with such a surface emitter 200.
  • the surface emitter 200 can be arranged in front of any of the lighting elements 20, 22, 24, 26, 28. It can be expedient to arrange it in front of the lighting element whose light is coupled directly into the optical path 54 without being redirected. On the side on which this lighting element is arranged, the installation space required for the surface emitter 200 is available, and the light paths from the other lighting elements can remain unaffected.
  • the surface radiator 200 is designed to generate background light and to emit it over a large area.
  • the surface radiator 200 has a light guide element 204, which is designed as a light guide plate.
  • the light guide element 204 is plate-shaped or plate-like. It has a radiation surface 224 from which the background light is emitted. Depending on the design, a further radiation surface opposite the radiation surface 224 can be provided.
  • the light guide element 204 can be anisotropic and/or one-sided in such a way that light is emitted primarily from the radiation surface 224 and not, or at least with considerably lower intensity, from a surface of the light guide element 204 opposite the radiation surface 224.
  • the surface radiator 200 also comprises a light source 202.
  • a light source 202 This is, for example, an LED array and/or a light bar that extends along a first edge 220 of the light guide element 204.
  • the first edge 220 can be a lower edge.
  • the light source 202 generates light and radiates it onto the first edge 220, whereby the light is coupled into the light guide element 204.
  • the light guide element 204 is provided in a generally known manner with scattering centers and/or coupling-out structures, due to which the radiated light is coupled out in a radiation direction 206. In the present arrangement, the light generated by the light element 202 is coupled laterally into the light guide element 204 with respect to the radiation direction 206. This allows the light source 202 to be arranged in a space-saving manner and outside of optical paths.
  • the optical waveguide element 204 has a bevel on a second edge 222 opposite the first edge 220. In the present case, this is an upper edge. Coupled-in light is reflected back into the optical waveguide element 204 at an angle at the second edge 222 and can thus interact more effectively with the scattering centers and/or coupling-out structures.
  • the second edge 222 can also be mirrored to enhance the effect. For example, a reflective layer can be applied to the second edge 222, for example a vapor-deposited and/or sputtered metal layer.
  • the light guide element 204 is designed to be translucent. It can therefore be arranged in such a way that illumination light from the light element 28 passes through the light guide element 204.
  • the light element 28 defines a radiation direction 208 for the illumination light.
  • the radiation direction 208 for the illumination light and the radiation direction 206 for the background light are oriented parallel to one another.
  • the illumination light and the background light therefore behave in a certain way as if they were coming from the same light source.
  • the background light thus simulates the light of a blue tongue or other light used for background illumination, as is regularly generated in the field of fluorescence endoscopy by setting a small overlap between the excitation filter and the observation filter.
  • the light source 202 and the light guide element 204 are selected and designed such that a light intensity of the illumination light is greater than a light intensity of the background light, in particular at least 2 times, at least 5 times, at least 10 times, at least 50 times or at least 100 times greater.
  • the background light is remitted by the object 120 to be imaged and can be superimposed on its fluorescent light. Due to the suitably selected low intensity, the remitted light and the fluorescent light can then be observed in parallel.
  • the lighting unit 18 is also designed to selectively switch the background light on and off independently of the illumination light by selectively switching the light source 202 on and off.
  • No movable filters or other movable mechanical elements are provided for generating or attenuating the background light. Simply switching the light element is therefore sufficient to switch the background light.
  • the background light can thus be switched on and off quickly and depending on the situation.
  • Operating modes can also be implemented in which the background light is switched at a certain repetition rate, in particular alternating with or in addition to the illumination light.
  • the light source 202 can basically have any spectrum. This can be broadband or narrowband. In particular for fluorescence applications it is expedient if the spectrum of the light source or the spectrum of the background light can at least partially pass through an observation filter used.
  • the light source 202 of the surface radiator 200 and that of the light elements 20, 22, 24, 26, 28 to which the surface radiator 200 is assigned can be coordinated with one another.
  • the light source 202 can be selected such that its spectrum is at the long-wave end of the spectrum of the relevant light element 20, 22, 24, 26, 28 and/or at the short-wave end of the associated observation filter used and/or forms an overlap in this wavelength range. Accordingly the Different light elements 20, 22, 24, 26, 28 can be assigned different surface radiators 200 or surface radiators 200 with different light sources 202, which differ with regard to the wavelength of the background light.
  • white light can be emitted as background light. This can then be partially blocked by the observation filter used, so that, for example, a blue tongue or an overlap area located in a different spectral range is formed.
  • the light source 202 is designed to emit optionally in different spectral ranges.
  • the light source 202 can, for example, comprise several different light elements that emit differently, such as LEDs of different colors or LEDs with adjustable color. This means that background light in different spectral ranges can also be optionally provided with a single surface emitter.
  • Fig. 5 shows a schematic perspective view of a second surface radiator 300 that can be used in the lighting device 12.
  • the surface radiator 300 is basically designed analogously to the surface radiator 200 and has a light source 302 that couples light laterally into a light guide element 304 of the surface radiator 300, which defines a radiation direction 306.
  • a light source 302 that couples light laterally into a light guide element 304 of the surface radiator 300, which defines a radiation direction 306.
  • the surface emitter 300 comprises an optical element 310, which in this case serves to deflect the illumination light. This is, for example, one of the beam splitter elements 90, 92, 94, 96 used in the lighting unit 16. Alternatively, it could also be a cover plate of a lighting element 20, 22, 24, 26, 28 or the like.
  • the optical element 310 is formed integrally with the light guide element 304. In the present case, the optical element 310 forms the light guide element 304.
  • the surface emitter 300 can therefore be integrated into the lighting unit 18 in a very space-efficient manner.
  • the light source 302 is designed as a light bar that couples light laterally into the light guide element 304.
  • a further light source 314 can be provided, which also couples light laterally into the light guide element 304.
  • the two light sources 304, 314 couple light from different sides or into different edges of the Light guide element 304.
  • the light source 302 radiates light in a first direction 316
  • the second light source 314 radiates light in a second direction 318.
  • the two directions 316, 318 are each at least substantially perpendicular to the emission direction 306 of the light guide element 304.
  • the two directions 316, 318 can be perpendicular to one another.
  • the directions 316, 318 can point to a center of the light guide element 304.
  • Light sources 302, 314 can be arranged along several edges and/or at least in sections along a circumference of the light guide element 304, whereby homogeneous illumination can be achieved.
  • Fig. 6 shows a schematic perspective view of a third surface radiator 400 that can be used in the lighting device.
  • the surface radiator 400 is basically designed analogously to the surface radiator 200 and has a light source 402 that couples light laterally into a light guide element 404 of the surface radiator 400, which defines a radiation direction 406.
  • a light source 402 that couples light laterally into a light guide element 404 of the surface radiator 400, which defines a radiation direction 406.
  • the surface radiator 400 has an optical element 410, which is one of the lenses 80, 82, 84, 86, 88 of the lighting unit 18.
  • the optical element 410 forms the light guide element 304, the lens 80, 82, 84, 86, 88 in question thus serves as the light guide element 304.
  • the optical element can be designed to suitably refract illumination light radiated by the associated lighting element 20, 22, 24, 26, 28, for example to collimate it in this case.
  • the optical element 410 can have suitable scattering centers and/or coupling-out structures so that light radiated by the light source 402 is emitted as background light over a large area.
  • the light guide element 404 thus has a dual function similar to the light guide element 304 described above, whereby a high degree of compactness can be achieved.
  • Fig. 7 shows a schematic representation of a fourth surface radiator 500 that can be used in the lighting device 12.
  • the surface radiator 500 is basically designed analogously to the surface radiator 200 and has a light source 502 that couples light laterally into a light guide element 504 of the surface radiator 500, which defines a radiation direction 506.
  • the light guide element 504 has a bevel on opposite edges 520, 522.
  • light radiated by the light source 502 is refracted at a first edge 520 as soon as it enters the light guide element 504. It is also deflected at a second edge 522, thereby achieving an extended light path and increased interaction with scattering centers and/or coupling-out structures of the light guide element.
  • Fig. 8 shows a schematic perspective view of a fifth surface radiator 600.
  • the surface radiator 600 is basically designed analogously to the surface radiator 200 and analogously to the surface radiator 300 and has a light source 602 that couples light laterally into a light guide element 604 of the surface radiator 600, which defines a radiation direction 606.
  • a light source 602 that couples light laterally into a light guide element 604 of the surface radiator 600, which defines a radiation direction 606.
  • the lighting unit 18 comprises a holder 612, which carries one of the crossed beam splitters 30, 32.
  • the surface radiator 600 comprises an optical element 610, which is one of the beam splitter elements 90, 92, 94, 96.
  • the optical element 610 forms the light guide element 604.
  • the light source 602 is integrated into the holder 612.
  • the light source 602 is integrated into a base of the holder 612 and is located below the optical element 610.
  • the light source can thus be arranged without requiring additional space and can couple light into the optical element 610.
  • the optical element 610 has a dual function and serves both to deflect illumination light and to emit background light.
  • coupling-out structures are provided in the light guide element 604, which cause a radiation direction 606 that is at an angle of approximately 45 degrees to the surface of the light guide element 604.
  • the background light is therefore emitted parallel to the common optical path 54 and is thus directed towards the optical interface 16.
  • a light guide element 604 can also be used in this variant, which radiates in a large angular range, for example more or less isotropically. At least part of the emitted light can then reach the optical interface 16. From the above description, it is clear how illumination light can be generated by means of the illumination device 12 in a method for generating illumination light for an imaging instrument 14. In addition, it is clear from the above description that a method for operating the imaging device can include supplying illumination light generated by means of the illumination device 12 to the imaging instrument 14.

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Abstract

La présente invention concerne un dispositif d'éclairage (12) comprenant une interface optique (16) pour la fixation optique d'un instrument de formation d'images (14) ; et une unité d'éclairage (18), qui est conçue pour fournir une lumière d'éclairage à l'interface optique (16), lumière au moyen de laquelle, dans un processus de formation d'images, un objet (120) à représenter peut être éclairé, et laquelle unité d'éclairage est également conçue pour fournir une lumière d'arrière-plan à l'interface optique (16), au moyen de laquelle l'objet (120) à représenter peut être éclairé afin de préparer et/ou d'évaluer la formation d'images. L'unité d'éclairage (18) comprend au moins un élément d'éclairage (20, 22, 24, 26, 28), qui est conçu pour générer la lumière d'éclairage, et au moins un émetteur plan (200 ; 300 ; 400 ; 500 ; 600), qui est conçu pour générer la lumière d'arrière-plan et pour l'émettre de manière plane, l'émetteur plan (200 ; 300 ; 400 ; 500 ; 600) comprenant une source de lumière (202 ; 302, 314 ; 402 ; 502 ; 602) et un élément de guide d'ondes (204 ; 304 ; 404 ; 504 ; 604), l'élément de guide d'ondes (204 ; 304 ; 404 ; 504 ; 604) définissant une direction d'émittance (206 ; 306 ; 406 ; 506 ; 606) pour la lumière d'arrière-plan, et la lumière générée par la source de lumière (202 ; 302 ; 402 ; 502 ; 602) pouvant être couplée dans l'élément de guide d'ondes (204 ; 304 ; 404 ; 504 ; 604) latéralement par rapport à la direction d'émittance (206 ; 306 ; 406 ; 506 ; 606). L'invention concerne également un dispositif de formation d'images (10) comprenant un dispositif d'éclairage (12) et un procédé associé pour fournir une lumière d'éclairage, ainsi qu'un procédé pour faire fonctionner un dispositif de formation d'images (10).
PCT/EP2023/081155 2022-11-11 2023-11-08 Dispositif d'éclairage et dispositif de formation d'images doté d'un dispositif d'éclairage Ceased WO2024100117A1 (fr)

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