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WO2024196897A1 - Nouveaux procédés pour accroître la vitesse de cicatrisation des plaies chez l'humain et les animaux - Google Patents

Nouveaux procédés pour accroître la vitesse de cicatrisation des plaies chez l'humain et les animaux Download PDF

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Publication number
WO2024196897A1
WO2024196897A1 PCT/US2024/020469 US2024020469W WO2024196897A1 WO 2024196897 A1 WO2024196897 A1 WO 2024196897A1 US 2024020469 W US2024020469 W US 2024020469W WO 2024196897 A1 WO2024196897 A1 WO 2024196897A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
wound
pdr
ions
zinc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/020469
Other languages
English (en)
Inventor
Courtland Imel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US18/124,657 external-priority patent/US20230302048A1/en
Application filed by Individual filed Critical Individual
Publication of WO2024196897A1 publication Critical patent/WO2024196897A1/fr
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Definitions

  • This disclosure is directed to a composition for treatment of mammal wounds including in humans and animals.
  • FIG. 1 illustrates a method of treating a wound of a mammal.
  • the disclosure describes a composition of novel ions, and the use of the composition of novel ions in speeding up the healing process of mammal wounds with a reduction of scarring.
  • these ions include Rubidium, Calcium, Zinc, and Potassium. These specific ions are referred to as a Protease Down Regulator (PDR).
  • PDR Protease Down Regulator
  • PDR is a wound management factor that normalizes aberrant biochemistry with non-healing wounds. Testing of PDR in cellular assays indicates that PDR acts on the gene expression level by down-regulating the genes for matrix metal proteinases and pro inflammatory cytokines, and up-regulates the genes for growth factors and tissue inhibitors of matrix metal proteinases. These four gene regulatory effects result in advantageous biochemical changes in the wound of human tissue toward a healing trajectory.
  • the present disclosure regulates the healing cascade at the gene expression level.
  • the PDR ions regulate the ability to heal the wound faster by increasing epithelialization and granulation, while reducing edema, inflammation, and exudate accumulation.
  • the method involves a PDR that is a mixture of Rubidium, Calcium, Zinc, and Potassium.
  • the mixture can be about 0.000001 to 10% Rubidium, 0.000001 to 10% Calcium, 0.000001 to 10% Zinc, and 0.000001 to 10% Potassium.
  • FIG. 1 illustrates method 100 having steps for treating a wound of a mammal.
  • the wound is cleaned.
  • the PDR is applied to the wound.
  • the wound is covered with the PDR material and then covered with a bandage to allow healing to occur.
  • the PDR can be embedded in the bandage.

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une composition de nouveaux ions, et l'utilisation de la composition de nouveaux ions pour accélérer le processus de cicatrisation des plaies chez les mammifères avec une réduction de l'apparition de cicatrices. Dans un mode de réalisation donné à titre d'exemple, ces ions comprennent le rubidium, le calcium, le zinc et le potassium. Ces ions spécifiques sont appelés modulateurs de protéase (PDR).
PCT/US2024/020469 2023-03-22 2024-03-18 Nouveaux procédés pour accroître la vitesse de cicatrisation des plaies chez l'humain et les animaux Pending WO2024196897A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18/124,657 2023-03-22
US18/124,657 US20230302048A1 (en) 2022-03-23 2023-03-22 Novel methods for increasing healing speed of human and animal wounds

Publications (1)

Publication Number Publication Date
WO2024196897A1 true WO2024196897A1 (fr) 2024-09-26

Family

ID=90735375

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/020469 Pending WO2024196897A1 (fr) 2023-03-22 2024-03-18 Nouveaux procédés pour accroître la vitesse de cicatrisation des plaies chez l'humain et les animaux

Country Status (1)

Country Link
WO (1) WO2024196897A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6149947A (en) * 1992-11-06 2000-11-21 Greystone Medical Group, Inc. Compositions of oak bark extract related synthetic compositions and method of using same
US20040105897A1 (en) * 2001-11-29 2004-06-03 Greystone Medical Group, Inc. Composition and method for the therapeutic modulation of matrix metalloproteinase
US20100196507A1 (en) * 2001-11-29 2010-08-05 Greystone Medical Group, Inc. Treatment of Wounds and Compositions Employed
US9351995B1 (en) * 2011-04-29 2016-05-31 Red Oax Holdings, LLC Compositions and methods of enhancing wound healing
US20170360982A1 (en) * 2015-01-29 2017-12-21 Mark Richard Wardell Wound Healing Composition Involving Mineral Ions and Methylglyoxal, and Methods of Use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6149947A (en) * 1992-11-06 2000-11-21 Greystone Medical Group, Inc. Compositions of oak bark extract related synthetic compositions and method of using same
US20040105897A1 (en) * 2001-11-29 2004-06-03 Greystone Medical Group, Inc. Composition and method for the therapeutic modulation of matrix metalloproteinase
US20100196507A1 (en) * 2001-11-29 2010-08-05 Greystone Medical Group, Inc. Treatment of Wounds and Compositions Employed
US9351995B1 (en) * 2011-04-29 2016-05-31 Red Oax Holdings, LLC Compositions and methods of enhancing wound healing
US20170360982A1 (en) * 2015-01-29 2017-12-21 Mark Richard Wardell Wound Healing Composition Involving Mineral Ions and Methylglyoxal, and Methods of Use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LIN PEI-HUI ET AL: "Zinc in Wound Healing Modulation", NUTRIENTS, vol. 10, no. 1, 24 December 2017 (2017-12-24), CH, pages 16, XP093105246, ISSN: 2072-6643, DOI: 10.3390/nu10010016 *
SUBRAMANIAM THAYAALINI ET AL: "The Role of Calcium in Wound Healing", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, no. 12, 2 June 2021 (2021-06-02), Basel, CH, pages 6486 - 1, XP093044883, ISSN: 1422-0067, DOI: 10.3390/ijms22126486 *

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