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WO2024184214A1 - Pompe à seringue - Google Patents

Pompe à seringue Download PDF

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Publication number
WO2024184214A1
WO2024184214A1 PCT/EP2024/055334 EP2024055334W WO2024184214A1 WO 2024184214 A1 WO2024184214 A1 WO 2024184214A1 EP 2024055334 W EP2024055334 W EP 2024055334W WO 2024184214 A1 WO2024184214 A1 WO 2024184214A1
Authority
WO
WIPO (PCT)
Prior art keywords
plunger
barrel
plunger drive
syringe pump
spindle structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2024/055334
Other languages
English (en)
Inventor
Nicolás CANDIA
Alejandro Lorca Mouliaá
Andreas Engel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cryowrite Ag
Original Assignee
Cryowrite Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cryowrite Ag filed Critical Cryowrite Ag
Priority to CN202480011040.8A priority Critical patent/CN120835957A/zh
Publication of WO2024184214A1 publication Critical patent/WO2024184214A1/fr
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B17/00—Pumps characterised by combination with, or adaptation to, specific driving engines or motors
    • F04B17/03—Pumps characterised by combination with, or adaptation to, specific driving engines or motors driven by electric motors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M2005/14573—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for quick connection/disconnection with a driving system

Definitions

  • the present invention relates to a syringe pump according to the preamble of claim 1.
  • Such high resolution and high precision syringe pumps are generally configured to eliminate all forces which are not aligned with an axis of a respective plunger element in order to provide motions which are smooth and repeatable with precision.
  • a linear actor arrangement which comprises a linear actor with two ends whose distance is variable depending on an energizing of the linear actor, wherein each end is attached to a respective first or second coupling element which engage a coupling surface.
  • the coupling surface and the coupling elements exhibit mating surface structures in such a manner that the coupling elements are prevented from moving in a direction while being allowed to move in an opposite direction.
  • US 2002/0095240 A1 a method for synchronizing a system for aspirating and/or dispensing liquid samples is described.
  • the system comprises a microejection device and a pump which are connected with one another by tubing, wherein a respective computer is capable of being implemented for loading an activatable computer program product for synchronizing the microejection device and pump.
  • the computer is made capable, on the basis of the loaded and activated computer program product, of controlling and synchronizing the following functions of this system: Active definition of a sample volume and dispensing of this defined sample volume with the microejection device, which is filled with sample liquid; Tracking of a part, which conveys the liquid, of the pump around a value, dependent on this sample volume, which is defined and is actively dispensed only by the microejection device, to prevent excessive pressure differences in the microejection device, tubing, and pump.
  • the invention relates to a syringe pump comprising a syringe unit with a barrel and a plunger, a first plunger drive having a spindle structure and a motor.
  • the barrel has a hollow interior and an outlet in fluid communication with the hollow interior, wherein the plunger extends into the hollow interior of the barrel and defines a chamber in the interior of the barrel.
  • the spindle structure of the first plunger drive is adapted for transforming a rotational movement of the motor into a translational movement, wherein the spindle structure of the first plunger drive is coupled to the plunger of the syringe unit such that the translational movement generated by the spindle structure moves the plunger relative to the barrel thereby changing a volume of the chamber in the interior of the barrel.
  • a second plunger drive is provided having a piezoelectric actuator member coupled to the plunger to move the plunger relative to the barrel thereby changing the volume of the chamber in the interior of the barrel.
  • the “first plunger drive” as specified herein relates to the side of the syringe pump where a rotational movement is mechanically transformed into a comparatively large translational movement (e.g. in the range of about 0.6 mm to about 1 .0 mm per revolution and with an total length of more than about 50 mm) and by means of which a comparatively large first partial volume (e.g. in the range of about 0.12 nanoliter per revolution and with a total volume of up to about 100 microliter) is delivered with an associated high precision.
  • a comparatively large translational movement e.g. in the range of about 0.6 mm to about 1 .0 mm per revolution and with an total length of more than about 50 mm
  • a comparatively large first partial volume e.g. in the range of about 0.12 nanoliter per revolution and with a total volume of up to about 100 microliter
  • the “second plunger drive” as specified herein relates to the (other) side of the syringe pump where a comparatively small translational movement (e.g. in the range of about 0.1 nm to about 0.5 nm per step and with a total length of about 15 micrometer) is created using a piezoelectric technique by means of which a comparatively small second partial volume (e.g. in the range of about 0.6 picoliter per step and with a total volume of about 23 nanoliter) is delivered with an associated (extremely) high precision.
  • a comparatively small translational movement e.g. in the range of about 0.1 nm to about 0.5 nm per step and with a total length of about 15 micrometer
  • a comparatively small second partial volume e.g. in the range of about 0.6 picoliter per step and with a total volume of about 23 nanoliter
  • a syringe pump may be provided which may deliver comparatively high liquid volumes with an extraordinary high precision respectively nominal resolution.
  • syringe unit as used herein, relates to any sort of syringe which is commonly used in the field of chemical-technical analysis.
  • the material for the syringe barrel and plunger may comprise for example glass or plastic materials, such as polypropylene or polyethylene, wherein the stopper of the syringe is however usually made of rubber material.
  • the “spindle structure” of the first plunger drive generally includes the components which perform the transformation of the rotational movement of e.g. a lead screw into a translational movement of e.g. an anti-backlash nut member being movably arranged on the lead screw.
  • the “piezoelectric actuator member” of the second plunger drive generally relates to a transducer that converts electrical energy into a mechanical displacement or stress based on a piezoelectric effect.
  • the piezoelectric actuator member and the motor of the first plunger drive are controlled by a respective control unit.
  • the first plunger drive is coupled to the plunger of the syringe unit via the second plunger drive such that the translational movement generated by the spindle structure of the first plunger drive moves the second plunger drive together with the plunger relative to the barrel.
  • a comparatively large first partial liquid volume of the liquid contained in the syringe barrel may be delivered with high precision.
  • the first plunger drive comprises a rail and the connector block is coupled to the rail such that the translational movement generated by the spindle structure moves the connector block along the rail. In doing so an extremely precise and repeatable translational movement can be generated.
  • the spindle structure of the first plunger drive comprises a lead screw element mounted to the motor and an anti-backlash nut member, the anti-backlash nut member being movably arranged on the lead screw element.
  • the anti-backlash nut member comprises a ball nut, in particular a preloaded ball nut (the preloading eliminates backlash).
  • the preloading eliminates backlash.
  • spindle structure of the first plunger drive is configured such that a full revolution of the lead screw element by the motor translates the anti-backlash nut member by a revolution distance in a range of between about 0.6 millimeter and 1 millimeter of between about 0.7 millimeter and about 0.9 millimeter, or particularly of between about 0.75 millimeter and about 0.85 millimeter. This has proven to be particularly effective for cryo writing applications.
  • the anti-backlash nut member of the spindle structure is stationarily mounted to the connector block and arranged between the motor of the first plunger drive and the connector block. This arrangement has to be proven to be very efficient in practice.
  • the motor of the first plunger drive is a stepper motor.
  • Stepper motors are DC motors which move in discrete steps. They comprise multiple coils that which are organized in groups respectively phases. By energizing each phase in sequence, the motor will rotate, one step at a time. Thus, with a computer controlled stepping one can achieve very precise positioning and/or speed control characteristics.
  • the motor of the first plunger drive is an encoded motor.
  • An encoded motor comprises a rotary encoder which is mounted to the respective electric motor and which provides closed loop feedback signals by tracking the speed and/or position of a motor shaft, which likewise provides for precise positioning and speed control.
  • the stepper motor has a microstepping resolution in a range of between about 51 ’000 steps per revolution to about 14’000 steps per revolution, of between about 12’500 steps per revolution to about 13’500 steps per revolution, or particularly of between about 12’700 steps per revolution and about 12’900 steps per revolution.
  • This configuration has proven to be particularly effective for cryo writing applications.
  • the first plunger drive is adapted such that the translational movement generated by the spindle structure is in a range of between 30 millimeter and about 70 millimeter, of between about 40 millimeter and about 60, or particularly of between about 45 and about 55 millimeter.
  • This configuration has proven to be particularly effective for use with syringes having a volume between 5 microliter and 1000 microliter and particularly preferred a volume of about 100 microliter.
  • the barrel of the syringe unit preferably has a nominal volume in a range of between about 5 microliter to about 1000 microliter, of between about 50 microliter and about 150 microliter, or particularly of about 80 microliter to about 110 microliter.
  • the plunger of the syringe unit comprises a stopper tightly closing the interior of the barrel.
  • the stopper is advantageously made of a rubber material or of a thermoplastic elastomer (TPE).
  • TPE thermoplastic elastomer
  • the piezoelectric actuator member of the second plunger drive comprises a stack of piezoelectric actuators. In this manner high precision respectively high nominal resolution of the second plunger drive can even be further improved.
  • the piezoelectric actuator member of second plunger drive is adapted to generate a translational movement to the plunger of the syringe unit in a range of between 5 micrometer and about 60 micrometer, of between about 10 micrometer and about 20 micrometer, or particularly of between about 13 micrometer to about 17 micrometer. This arrangement has proven to be particularly effective for cryo writing applications.
  • the piezoelectric actuator member of second plunger drive is adapted to generate a translational movement to the plunger of the syringe unit in a resolution of between about 0.1 nanometer to about 0.5 nanometer, of between about 0.2 nanometer and about 0.4 nanometer, or particularly of about 0.3 nanometer.
  • resolution has likewise proven to be particularly effective for cryo writing applications.
  • Fig. 1 shows a top perspective view of an inventive syringe pump in the assembled state
  • Fig. 2 shows a top exploded view of the inventive syringe pump according to Fig. 1 ; and Fig. 3 shows a bottom perspective view of the inventive syringe pump according to Fig. 1.
  • FIG. 1 shows a top perspective view of an inventive syringe pump 1 in the assembled state.
  • the syringe pump 1 comprises a housing 3 to which the individual components of the syringe pump 1 are attached directly or indirectly.
  • a first plunger drive 2 which comprises a spindle structure 21 and a motor 22.
  • the spindle structure 21 of the first plunger drive 2 is adapted for transforming a rotational movement of the motor 22 into a translational movement.
  • the spindle structure 21 is (indirectly) coupled to the plunger 82 of the syringe unit 8 such that the translational movement generated by the spindle structure 21 moves the plunger 82 relative to the barrel 81 thereby changing a volume of the chamber in the interior of the barrel 81 , i.e. in particular for delivering liquid content but generally also for taking up liquid content.
  • the first plunger drive 2 comprises a lead screw element 211 which is coupled to the motor 22 of the syringe pump 1 by means of a coupling member 213.
  • a coupling member 213 On the lead screw element 211 there is movably arranged an anti-backlash nut member 212 which may be in the form of a preloaded ball nut member.
  • the anti-backlash nut member 212 is attached to a connector block 4 which is slideably arranged on a rail 31 attached to the housing 3. The distal end of the lead screw element is received in a ball bearing 6 as further measure to reduce friction.
  • a syringe unit 8 with a barrel 81 and a plunger 82.
  • the plunger 82 extends into the hollow interior of the barrel 81 and defines a chamber in the hollow interior of the barrel 81.
  • the barrel 81 further comprises and an outlet 811 which is in fluid communication with the hollow interior.
  • the barrel 82 is mounted at the housing 3 by means of a mounting bracket 9.
  • the plunger 82 of the syringe unit 8 is coupled to piezoelectric actuator member 71 thereby forming a second plunger drive 7 of the syringe pump 1 .
  • the connector block 4 is coupled to the piezoelectric actuator member 71 , thereby establishing the coupling between the first plunger drive 2 and the second plunger drive 7.
  • the first plunger drive 2 respectively motor 22 and the second plunger drive 7, respectively piezoelectric actuator member 71 are controlled by control unit 10 (see dashed arrows).
  • Fig. 2 illustrates a top exploded view of the inventive syringe pump described above.
  • slider member 5 which is slideably arranged on the rail 31 and to which the connector block 4 is attached in the assembled state.
  • Anti- backlash nut member 212 is stationarily mounted to the connector block 4 which thus moves along the lead screw element 211 together with the anti-backlash nut member in a direction set by motor 22 respectively by control unit 10.
  • the connector block 4 further comprises a C-shaped engagement structure 42 for the plunger 82 respectively its proximal end portion 821 .
  • the connector block 4 further comprises a holding structure 41 for the piezoelectric actuator member 71 , the piezoelectric actuator member 71 being operatively coupled to the engagement structure 42 for the proximal end portion 822 of plunger 82.
  • Fig. 3 depicts a bottom perspective view of the inventive syringe pump 1 .
  • the second plunger drive 7 is well recognisable.
  • the holding structure 41 and the engagement structure 42 of the connector block 4 extend through a longitudinal opening in the housing 3.
  • the proximal end portion of plunger 82 is fully received in the C-shaped engagement structure 42 and the piezoelectric actuator member 71 abuts at the top surface of the C-shaped engagement structure 42.
  • an optimal transmission of the translational movement generated by the piezoelectric actuator member (upon reception of a respective electric signal from control unit 10) onto the plunger 82 may be achieved for ensuring the extremely high precision respectively nominal resolution of the second plunger drive 7.
  • the control unit 10 includes a computer program that may be stored/distributed on a suitable medium, such as an optical storage medium or a solid-state medium supplied together with or as part of other hardware, but may also be distributed in other forms, such as via the Internet or other wired or wireless telecommunication systems.
  • a computer program can be a computer program product stored on a computer readable medium which computer program product can have computer executable program code adapted to be executed to implement a specific method such as the method according to the invention.
  • a computer program can also be a data structure product or a signal for embodying a specific method such as the method according to the invention.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne une pompe à seringue (1) comprenant une unité de seringue (8) avec un cylindre (81) et un piston (82) et un premier entraînement de piston (2) ayant une structure de broche (21) et un moteur (22). Le cylindre (81) présente un intérieur creux et une sortie (811) en communication fluidique avec l'intérieur creux, le piston (82) s'étendant dans l'intérieur creux du cylindre (81) et délimitant une chambre à l'intérieur du cylindre (81). La structure de broche (21) du premier entraînement de piston (2) est conçue pour transformer un mouvement de rotation du moteur (22) en un mouvement de translation, la structure de broche (21) du premier entraînement de piston (2) étant accouplée au piston (82) de l'unité de seringue (8) de sorte que le mouvement de translation généré par la structure de broche (21) déplace le piston (82) par rapport au cylindre (81), ce qui permet de modifier un volume de la chambre à l'intérieur du cylindre (81). Ainsi, l'invention concerne également un second entraînement de piston (7) comprenant un élément actionneur piézoélectrique (71) accouplé au piston (82) pour déplacer le piston (82) par rapport au cylindre (81), ce qui permet de modifier le volume de la chambre à l'intérieur du cylindre (81).
PCT/EP2024/055334 2023-03-03 2024-03-01 Pompe à seringue Pending WO2024184214A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202480011040.8A CN120835957A (zh) 2023-03-03 2024-03-01 泵式注射器

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH2252023 2023-03-03
CHCH000225/2023 2023-03-03

Publications (1)

Publication Number Publication Date
WO2024184214A1 true WO2024184214A1 (fr) 2024-09-12

Family

ID=90123970

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2024/055334 Pending WO2024184214A1 (fr) 2023-03-03 2024-03-01 Pompe à seringue

Country Status (2)

Country Link
CN (1) CN120835957A (fr)
WO (1) WO2024184214A1 (fr)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020095240A1 (en) 2000-11-17 2002-07-18 Anselm Sickinger Method and device for separating samples from a liquid
WO2003078066A1 (fr) * 2002-03-13 2003-09-25 The Automation Partnership (Cambridge) Limited Distributeur de gouttelettes a faible volume
EP1124600B1 (fr) * 1998-10-29 2005-02-23 Medtronic MiniMed, Inc. Systeme d'entrainement compact pour pompe
US6869571B2 (en) * 2000-11-17 2005-03-22 Tecan Trading Ag Device for aspirating and dispensing liquid samples
US20130048759A1 (en) * 2011-08-26 2013-02-28 Nordson Corporation Modular jetting devices
WO2014001309A1 (fr) 2012-06-27 2014-01-03 Sanofi-Aventis Deutschland Gmbh Agencement d'actionneur linéaire
US20140150580A1 (en) * 2012-12-01 2014-06-05 John McEntee Rotary to linear transmission
EP3124066B1 (fr) * 2014-03-26 2018-09-26 Terumo Kabushiki Kaisha Dispositif d'administration de médicament liquide
EP2929900B1 (fr) * 2014-04-11 2019-02-20 Andreas Gerzen Dispositif d'injection destiné à l'application continue et régulière d'une substance d'injection

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1124600B1 (fr) * 1998-10-29 2005-02-23 Medtronic MiniMed, Inc. Systeme d'entrainement compact pour pompe
US20020095240A1 (en) 2000-11-17 2002-07-18 Anselm Sickinger Method and device for separating samples from a liquid
US6869571B2 (en) * 2000-11-17 2005-03-22 Tecan Trading Ag Device for aspirating and dispensing liquid samples
WO2003078066A1 (fr) * 2002-03-13 2003-09-25 The Automation Partnership (Cambridge) Limited Distributeur de gouttelettes a faible volume
US20130048759A1 (en) * 2011-08-26 2013-02-28 Nordson Corporation Modular jetting devices
WO2014001309A1 (fr) 2012-06-27 2014-01-03 Sanofi-Aventis Deutschland Gmbh Agencement d'actionneur linéaire
US20140150580A1 (en) * 2012-12-01 2014-06-05 John McEntee Rotary to linear transmission
EP3124066B1 (fr) * 2014-03-26 2018-09-26 Terumo Kabushiki Kaisha Dispositif d'administration de médicament liquide
EP2929900B1 (fr) * 2014-04-11 2019-02-20 Andreas Gerzen Dispositif d'injection destiné à l'application continue et régulière d'une substance d'injection

Also Published As

Publication number Publication date
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