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WO2024182511A3 - Microneedle wound monitoring systems, devices and methods - Google Patents

Microneedle wound monitoring systems, devices and methods Download PDF

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Publication number
WO2024182511A3
WO2024182511A3 PCT/US2024/017666 US2024017666W WO2024182511A3 WO 2024182511 A3 WO2024182511 A3 WO 2024182511A3 US 2024017666 W US2024017666 W US 2024017666W WO 2024182511 A3 WO2024182511 A3 WO 2024182511A3
Authority
WO
WIPO (PCT)
Prior art keywords
microneedle
layer
scaffold
array
wound
Prior art date
Application number
PCT/US2024/017666
Other languages
French (fr)
Other versions
WO2024182511A2 (en
Inventor
Miles MASSIDDA
James Clarke
Nicholas Schneider
Scott ALPARD
Cristina CHECKA
Joseph Schmidt
Khashayar MOSHKSAYAN
Original Assignee
Board Of Regents, The University Of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Board Of Regents, The University Of Texas System filed Critical Board Of Regents, The University Of Texas System
Publication of WO2024182511A2 publication Critical patent/WO2024182511A2/en
Publication of WO2024182511A3 publication Critical patent/WO2024182511A3/en
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/685—Microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

A wound monitoring system comprises a microneedle scaffold layer including a microneedle array positioned on a first surface of the microneedle scaffold layer, a microfluidics layer above the microneedle scaffold layer and opposite the microneedle array, and a sensor layer above the microfluidic layer and opposite the microneedle scaffold layer. A wound monitoring method comprises providing and applying the system to a subject to collect interstitial fluid (ISF) from the microneedle array to the assay chamber via the microneedle scaffold layer and the microfluidics layer, collecting physiological data based on dielectric or chemical properties of the ISF as measured by the electrochemical sensor array, and categorizing a wound physiological state. A microneedle array comprises a plurality of microneedles comprising polylactic acid (PLA), wherein the microneedles have a height of 500- 950 pm, base diameter of 150-450 pm, swelling percentage of 25%-175%, and porosity of 30%- 80%.
PCT/US2024/017666 2023-02-28 2024-02-28 Microneedle wound monitoring systems, devices and methods Pending WO2024182511A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363487375P 2023-02-28 2023-02-28
US63/487,375 2023-02-28

Publications (2)

Publication Number Publication Date
WO2024182511A2 WO2024182511A2 (en) 2024-09-06
WO2024182511A3 true WO2024182511A3 (en) 2025-01-30

Family

ID=92590373

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/017666 Pending WO2024182511A2 (en) 2023-02-28 2024-02-28 Microneedle wound monitoring systems, devices and methods

Country Status (1)

Country Link
WO (1) WO2024182511A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030135161A1 (en) * 2002-01-15 2003-07-17 Fleming Patrick R. Microneedle devices and methods of manufacture
US9987361B1 (en) * 2014-12-29 2018-06-05 Noven Pharmaceuticals, Inc. Compositions and method for sustained drug delivery by active transdermal technology
US20210402182A1 (en) * 2018-10-02 2021-12-30 WearOptimo Pty Ltd Treatment delivery system
US20220003676A1 (en) * 2006-12-06 2022-01-06 Mohammad A. Mazed Optical biomodule for detection of diseases at an early onset

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030135161A1 (en) * 2002-01-15 2003-07-17 Fleming Patrick R. Microneedle devices and methods of manufacture
US20220003676A1 (en) * 2006-12-06 2022-01-06 Mohammad A. Mazed Optical biomodule for detection of diseases at an early onset
US9987361B1 (en) * 2014-12-29 2018-06-05 Noven Pharmaceuticals, Inc. Compositions and method for sustained drug delivery by active transdermal technology
US20210402182A1 (en) * 2018-10-02 2021-12-30 WearOptimo Pty Ltd Treatment delivery system

Also Published As

Publication number Publication date
WO2024182511A2 (en) 2024-09-06

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