WO2024180304A1 - Device for dispensing a fluid product - Google Patents
Device for dispensing a fluid product Download PDFInfo
- Publication number
- WO2024180304A1 WO2024180304A1 PCT/FR2024/050261 FR2024050261W WO2024180304A1 WO 2024180304 A1 WO2024180304 A1 WO 2024180304A1 FR 2024050261 W FR2024050261 W FR 2024050261W WO 2024180304 A1 WO2024180304 A1 WO 2024180304A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- insert
- cannula
- cup
- front part
- reservoir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/34—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl
- B05B1/3405—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl
- B05B1/341—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet
- B05B1/3421—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber
- B05B1/3431—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves
- B05B1/3436—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves the interface being a plane perpendicular to the outlet axis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
Definitions
- the present invention relates to a fluid product dispensing device, in particular intended for the administration of pharmaceutical product, in particular to small animals, such as for example mice.
- State-of-the-art devices used to administer doses of drugs to small animals are generally single-dose, single-use devices, in which the entire dose of product is dispensed in a single actuation.
- drug testing on animals in particular rodents such as mice, is generally carried out on about fifteen rodents, which therefore requires about fifteen devices.
- the doses are generally not adjustable, so that a different device is required for each different dosage.
- these devices generally use a small diameter cannula to distribute the fluid product, typically with an external diameter of 0.7 mm and an internal diameter of 0.4 mm.
- a small diameter cannula to distribute the fluid product, typically with an external diameter of 0.7 mm and an internal diameter of 0.4 mm.
- this achieves a dose distribution in the form of a rectilinear jet, whereas it is preferable to be able to achieve this distribution in the form of a spray.
- a spray with a Dv50 of less than 30 pm is desirable.
- the aim of the present invention is to provide a fluid product dispensing device which does not reproduce the aforementioned drawbacks.
- the present invention aims in particular to provide a fluid product dispensing device which makes it possible to dispense the fluid product at the outlet of a small diameter cannula in the form of a spray.
- the present invention also aims to provide a fluid product dispensing device which is simple and reliable to use.
- the present invention also aims to provide a fluid product dispensing device which makes it possible to dispense several doses in several successive uses.
- the present invention also aims to provide a fluid product dispensing device which allows the dosage to be modified with each use.
- the present invention also aims to provide a fluid product dispensing device which is simple and inexpensive to manufacture and assemble.
- the present invention therefore relates to a fluid product dispensing device comprising a reservoir adapted to contain at least one dose of fluid product and a dispensing head fixed to said reservoir, said dispensing head comprising a cannula provided with a front part, said cannula comprising a spray tip inserted into said front part, said spray tip comprising an insert and a cup, said cup being arranged above said insert and comprising an axial orifice forming a dispensing orifice, said insert being provided with a spray profile comprising at least one non-radial groove, at least one wall part running along each non-radial groove, and a central swirl chamber defined radially inside said at least one wall part.
- said insert comprises at least one external groove, preferably axial, extending over the entire axial length of the insert, to allow the passage of fluid during actuation.
- said insert comprises at least two external grooves.
- said at least two non-radial grooves and said at least two wall portions connect said at least two external grooves.
- said insert and said cup are force-fitted into said front part of said cannula.
- said cup comprises a hollow cylindrical sleeve containing a truncated cone-shaped hollow which narrows towards the front part of the cup, where said truncated cone-shaped hollow connects to a cylindrical hollow forming said dispensing orifice.
- said insert and said cup are entirely arranged inside said front part of said cannula.
- said dispensing head is removably connected to said reservoir.
- said dispensing head is removably fixed to said reservoir, in particular via a Luer type fixing, said cannula being fixed, in particular welded, to said dispensing head.
- the external diameter of said front part of said cannula is less than 1 mm, advantageously less than 0.8 mm, preferably approximately 0.7 mm.
- the internal diameter of said front part of said cannula is less than 0.7 mm, advantageously less than 0.5 mm, preferably approximately 0.4 mm.
- said cannula is curved or bent.
- said reservoir is a syringe comprising a body and a piston sliding in said body during actuation.
- the spray generated has a Dv50 of less than 30 pm, advantageously less than 25 pm, in particular less than or equal to 20 pm.
- FIG. 1 is a schematic perspective view of a fluid product dispensing device according to an advantageous embodiment
- FIG. 2 is a vertical section view of a cup
- FIG. 1 is a schematic perspective view of a fluid product dispensing device according to an advantageous embodiment
- FIG. 2 is a vertical section view of a cup
- FIG. 3 is a schematic perspective detail view of a spray tip according to a first advantageous embodiment, comprising an insert and a cup, before their assembly in a cannula
- Figure 4 is a schematic top view of the insert of Figure 3
- Figure 5 is a schematic view similar to that of Figure 3, after assembly of the insert and the cup in the cannula
- Figure 6 is a schematic top view in transparency of the spray tip, after assembly of the cup over the insert
- Figure 7 is a schematic cross-sectional view of the upper end of the insert of Figures 3 to 6
- Figure 8 is a view similar to that of Figure 7, showing an insert according to a second advantageous embodiment
- Figure 9 is a view similar to those of Figures 7 and 8, showing an insert according to a third advantageous embodiment.
- axial and radial refer to the longitudinal central axis A of the dispensing device shown in Figure 5.
- above, “below”, “upper” and “lower” refer to a vertical position as shown in Figures 3 and 5.
- forward refers to the direction of flow of the fluid product upon actuation.
- the fluid product dispensing device shown in Figure 1 comprises a reservoir 1 containing one or more doses of fluid product and a dispensing head 2 comprising a cannula 3 having at its front part 4 a dispensing orifice 5.
- the reservoir 1 is advantageously a syringe comprising a body 6 and a piston (not visible in FIG. 1) sliding in said body 6 during actuation.
- a piston rod 7 is preferably fixed to the piston to allow the user to actuate the device.
- This piston rod 7 may comprise at its rear end a radial flange 8 to facilitate gripping by a user.
- the body 6 has an open front end adapted to receive the dispensing head 2, preferably in a removable manner.
- This attachment of the dispensing head 2 to the reservoir 1 can for example be carried out via a conventional Luer Lock type attachment. Other attachment means are conceivable, for example screwing or snap-fastening.
- the cannula 3 forms a hollow tube defining a small diameter expulsion channel.
- the external diameter of the front part 4 of the cannula is less than 1 mm, advantageously less than 0.8 mm, preferably about 0.7 mm.
- the internal diameter of the front part 4 of the cannula is typically less than 0.7 mm, advantageously less than 0.5 mm, preferably about 0.4 mm.
- the cannula 3 is bent, but it could be straight or curved, or of any suitable shape. It can be rigid, or alternatively partially or completely flexible.
- the rear part of the cannula 3 is welded to the dispensing head 2, but other fixing means are conceivable, for example a force fitting or gluing.
- the cannula 3 comprises a spray tip 10.
- This spray tip 10 provided in the front part 4 of the cannula 3 allows the fluid product to be distributed in the form of a spray.
- This spray tip 10 comprises an insert 11 which is inserted into the front part 4 of the cannula 3 and a cup 12 arranged above the insert 11, also in the front part 4 of the cannula 3, and comprising an axial orifice forming the dispensing orifice 5.
- the insert 11 has an external diameter approximately equal to the internal diameter of the cannula 3.
- the insert 11 is force-fitted into the front part 4 of the cannula 3.
- the cup 12 has an external diameter approximately equal to the internal diameter of the cannula 3.
- the cup 12 is force-fitted into the front part 4 of the cannula 3.
- the insert 11 comprises at least one external groove 15 extending over the entire axial length of the insert, to allow the passage of fluid during actuation.
- said at least one external groove 15 is axial.
- said at least one external groove 15 could be non-axial, in particular oblique around the insert 11.
- the insert 11 comprises at least two external grooves 15.
- the width of each external groove 15 is less than 0.2 mm, advantageously less than 0.1 mm, preferably approximately 0.08 mm.
- the insert 11 comprises a spray profile for generating a spray.
- This spray profile comprises at least one non-radial groove 16, at least one wall portion 17 running along each non-radial groove 16, and a central swirl chamber 19 defined radially inside said at least one wall portion 17.
- the axial height of each wall portion 17 is less than 0.15 mm, advantageously less than 0.12 mm, preferably approximately 0.1 mm.
- the cup 12 In the assembled position, the cup 12 is in contact with the insert 11, in particular with the upper axial edge of each wall part 17.
- the fluid product flows axially into the cannula 3, then axially into the at least one axial external groove 15, then in a swirling manner in the central swirl chamber 19, being guided by the at least one non-radial groove 16 along the at least one wall portion 17, which swirls the fluid in the swirl chamber 19 and generates a spray through the dispensing orifice 5 formed in the cup 12.
- the properties of the spray generated can be modified.
- the insert 11 and the cup 12 are entirely arranged inside the front part 4 of the cannula 3, so that the presence of the spray tip 10 does not increase the external diameter of the cannula, and does not modify its use.
- the invention makes it possible to generate a correct spray, based on the one hand on the geometry and velocity of the spray, and on the other hand on the granulometry of the spray drops (DSD: "Drop Size Distribution”); thus, the three embodiments described above make it possible to obtain a Dv50 of less than 30 pm;
- the first embodiment has particularly good spray properties, with an average Dv50 less than or equal to 20 pm.
- the tank 1 Before the first use, the tank 1 can be empty and separated from the dispensing head 2. It is then preferably closed by a cap (not shown), in a known manner.
- the user who wishes to use the device removes the cap from the reservoir 1 and fills it with fluid product.
- fluid product For example, in the case of a syringe, he draws fluid product from a fluid product reserve, by pulling the piston backwards in the body 6.
- the reservoir 1 can be filled with a dose of chosen volume, or alternatively with two or more doses.
- the device is then ready for its first active use, to dispense a dose of fluid product.
- the piston rod 7 When the user presses the piston rod 7, he moves the piston relative to the body 6. Fluid product contained in the reservoir 1 is then expelled into the cannula 3 and then sprayed by the spray tip 10.
- all of the fluid product contained in the reservoir 1 is dispensed in a single actuation.
- the contents of the tank may be dispensed in two or more successive actuations.
- the user can remove the dispensing head 2, and refill the tank 1 in a known manner for the next use of the device.
- spray tip 10 could also be used with a pre-filled reservoir and/or a single-use device disposable after use.
- a preferred application of the present invention relates to the administration of pharmaceutical product to small animals, such as for example mice.
- An application in humans is however also conceivable.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
Description
Dispositif de distribution de produit fluide Fluid product dispensing device
La présente invention concerne un dispositif de distribution de produit fluide, notamment destiné à l'administration de produit pharmaceutique, en particulier à des petits animaux, tels que par exemple des souris. The present invention relates to a fluid product dispensing device, in particular intended for the administration of pharmaceutical product, in particular to small animals, such as for example mice.
Les dispositifs de l'état de la technique utilisés pour administrer des doses de médicaments à des petits animaux, tels que des rongeurs, notamment des souris, sont généralement des dispositifs unidose à usage unique, dans lesquelles la totalité de la dose de produit est distribuée en un seul actionnement. Or, les essais de médicaments sur des animaux, en particulier des rongeurs tels que des souris, se font en général sur une quinzaine de rongeurs, ce qui demande donc une quinzaine de dispositifs. De plus, les doses ne sont généralement pas réglables, de sorte qu'il faut un dispositif différent pour chaque dosage différent. State-of-the-art devices used to administer doses of drugs to small animals, such as rodents, in particular mice, are generally single-dose, single-use devices, in which the entire dose of product is dispensed in a single actuation. However, drug testing on animals, in particular rodents such as mice, is generally carried out on about fifteen rodents, which therefore requires about fifteen devices. In addition, the doses are generally not adjustable, so that a different device is required for each different dosage.
Par ailleurs, ces dispositifs utilisent généralement une canule de faible diamètre pour distribuer le produit fluide, typiquement avec un diamètre externe de 0,7 mm et un diamètre interne de 0,4 mm. Or, ceci réalise une distribution de dose sous forme d'un jet rectiligne, alors qu'il est préférable de pouvoir réaliser cette distribution sous la forme d'un spray. En particulier dans le cadre d'essais pré-cliniques sur des petits animaux, un spray avec un Dv50 inférieur à 30 pm est souhaitable. Furthermore, these devices generally use a small diameter cannula to distribute the fluid product, typically with an external diameter of 0.7 mm and an internal diameter of 0.4 mm. However, this achieves a dose distribution in the form of a rectilinear jet, whereas it is preferable to be able to achieve this distribution in the form of a spray. In particular in the context of pre-clinical trials on small animals, a spray with a Dv50 of less than 30 pm is desirable.
Les documents US5605255, WO9746324, US2015273486 et WO201 9086272 décrivent des embouts de pulvérisation, mais aucun n'est adapté pour être inséré dans une canule de faible diamètre. US5605255, WO9746324, US2015273486 and WO201 9086272 describe spray tips, but none are suitable for insertion into a small diameter cannula.
La présente invention a pour but de fournir un dispositif de distribution de produit fluide qui ne reproduit pas les inconvénients susmentionnés. The aim of the present invention is to provide a fluid product dispensing device which does not reproduce the aforementioned drawbacks.
La présente invention a notamment pour but de fournir un dispositif de distribution de produit fluide qui permette de distribuer le produit fluide à la sortie d'une canule de faible diamètre sous la forme d'un spray. The present invention aims in particular to provide a fluid product dispensing device which makes it possible to dispense the fluid product at the outlet of a small diameter cannula in the form of a spray.
La présente invention a aussi pour but de fournir un dispositif de distribution de produit fluide qui soit simple et fiable d'utilisation. La présente invention a aussi pour but de fournir un dispositif de distribution de produit fluide qui permette de distribuer plusieurs doses en plusieurs utilisations successives. The present invention also aims to provide a fluid product dispensing device which is simple and reliable to use. The present invention also aims to provide a fluid product dispensing device which makes it possible to dispense several doses in several successive uses.
La présente invention a également pour but de fournir un dispositif de distribution de produit fluide qui permette de modifier le dosage à chaque utilisation. The present invention also aims to provide a fluid product dispensing device which allows the dosage to be modified with each use.
La présente invention a également pour but de fournir un dispositif de distribution de produit fluide qui soit simple et peu coûteux à fabriquer et à assembler. The present invention also aims to provide a fluid product dispensing device which is simple and inexpensive to manufacture and assemble.
La présente invention a donc pour objet un dispositif de distribution de produit fluide comportant un réservoir adapté à contenir au moins une dose de produit fluide et une tête de distribution fixée audit réservoir, ladite tête de distribution comportant une canule pourvue d'une partie avant, ladite canule comportant un embout de pulvérisation inséré dans ladite partie avant, ledit embout de pulvérisation comportant un insert et une coupelle, ladite coupelle étant disposée par-dessus ledit insert et comportant un orifice axial formant orifice de distribution, ledit insert étant pourvu d'un profil de pulvérisation comportant au moins une gorge non radiale, au moins une partie de paroi longeant chaque gorge non radiale, et une chambre centrale de tourbillonnement définie radialement à l'intérieur de ladite au moins une partie de paroi. The present invention therefore relates to a fluid product dispensing device comprising a reservoir adapted to contain at least one dose of fluid product and a dispensing head fixed to said reservoir, said dispensing head comprising a cannula provided with a front part, said cannula comprising a spray tip inserted into said front part, said spray tip comprising an insert and a cup, said cup being arranged above said insert and comprising an axial orifice forming a dispensing orifice, said insert being provided with a spray profile comprising at least one non-radial groove, at least one wall part running along each non-radial groove, and a central swirl chamber defined radially inside said at least one wall part.
Avantageusement, ledit insert comporte au moins une rainure externe, de préférence axiale, s'étendant sur toute la longueur axiale de l'insert, pour permettre le passage du fluide lors de l'actionnement. Advantageously, said insert comprises at least one external groove, preferably axial, extending over the entire axial length of the insert, to allow the passage of fluid during actuation.
Avantageusement, ledit insert comporte au moins deux rainures externes. Advantageously, said insert comprises at least two external grooves.
Avantageusement, lesdites au moins deux gorges non radiales et lesdites au moins deux parties de paroi relient lesdites au moins deux rainures externes. Advantageously, said at least two non-radial grooves and said at least two wall portions connect said at least two external grooves.
Avantageusement, ledit insert et ladite coupelle sont emmanchés à force dans ladite partie avant de ladite canule. Avantageusement, ladite coupelle comporte un manchon creux cylindrique contenant un creux de forme tronconique qui se rétrécie en direction de la partie avant de la coupelle, où ledit creux tronconique se connecte à un creux cylindrique formant ledit orifice de distribution. Advantageously, said insert and said cup are force-fitted into said front part of said cannula. Advantageously, said cup comprises a hollow cylindrical sleeve containing a truncated cone-shaped hollow which narrows towards the front part of the cup, where said truncated cone-shaped hollow connects to a cylindrical hollow forming said dispensing orifice.
Avantageusement, ledit insert et ladite coupelle sont en totalité disposés à l'intérieur de ladite partie avant de ladite canule. Advantageously, said insert and said cup are entirely arranged inside said front part of said cannula.
Avantageusement, ladite tête de distribution est reliée de manière amovible audit réservoir. Advantageously, said dispensing head is removably connected to said reservoir.
Avantageusement, ladite tête de distribution est fixée de manière amovible sur ledit réservoir, notamment via une fixation du type Luer, ladite canule étant fixée, notamment soudée, à ladite tête de distribution. Advantageously, said dispensing head is removably fixed to said reservoir, in particular via a Luer type fixing, said cannula being fixed, in particular welded, to said dispensing head.
Avantageusement, le diamètre externe de ladite partie avant de ladite canule est inférieur à 1 mm, avantageusement inférieur à 0,8 mm, de préférence environ 0,7 mm. Advantageously, the external diameter of said front part of said cannula is less than 1 mm, advantageously less than 0.8 mm, preferably approximately 0.7 mm.
Avantageusement, le diamètre interne de ladite partie avant de ladite canule est inférieur à 0,7 mm, avantageusement inférieur à 0,5 mm, de préférence environ 0,4 mm. Advantageously, the internal diameter of said front part of said cannula is less than 0.7 mm, advantageously less than 0.5 mm, preferably approximately 0.4 mm.
Avantageusement, ladite canule est courbe ou coudée. Advantageously, said cannula is curved or bent.
Avantageusement, ledit réservoir est une seringue comportant un corps et un piston coulissant dans ledit corps lors de l'actionnement. Advantageously, said reservoir is a syringe comprising a body and a piston sliding in said body during actuation.
Avantageusement, le spray généré a un Dv50 inférieur à 30 pm, avantageusement inférieur à 25 pm, notamment inférieur ou égal à 20 pm. Advantageously, the spray generated has a Dv50 of less than 30 pm, advantageously less than 25 pm, in particular less than or equal to 20 pm.
Ces caractéristiques et avantages et d’autres de la présente invention apparaîtront plus clairement au cours de la description détaillée suivante, faite en référence aux dessins joints, donnés à titre d’exemples non limitatifs, et sur lesquels : la figure 1 est une vue schématique en perspective d'un dispositif de distribution de produit fluide selon un mode de réalisation avantageux, la figure 2 est une vue en section verticale d'une coupelle, la figure 3 est une vue schématique de détail en perspective d'un embout de pulvérisation selon un premier mode de réalisation avantageux, comportant un insert et une coupelle, avant leur assemblage dans une canule, la figure 4 est une vue schématique de dessus de l'insert de la figure 3, la figure 5 est une vue schématique similaire à celle de la figure 3, après assemblage de l'insert et de la coupelle dans la canule, la figure 6 est une vue schématique de dessus en transparence de l'embout de pulvérisation, après assemblage de la coupelle par-dessus l'insert, la figure 7 est une vue schématique en section transversale de l'extrémité supérieure de l'insert des figures 3 à 6, la figure 8 est une vue similaire à celle de la figure 7, montrant un insert selon un second mode de réalisation avantageux, et la figure 9 est une vue similaire à celles des figures 7 et 8, montrant un insert selon un troisième mode de réalisation avantageux. These and other features and advantages of the present invention will become more clearly apparent during the following detailed description, made with reference to the attached drawings, given as non-limiting examples, and in which: FIG. 1 is a schematic perspective view of a fluid product dispensing device according to an advantageous embodiment, FIG. 2 is a vertical section view of a cup, FIG. 3 is a schematic perspective detail view of a spray tip according to a first advantageous embodiment, comprising an insert and a cup, before their assembly in a cannula, Figure 4 is a schematic top view of the insert of Figure 3, Figure 5 is a schematic view similar to that of Figure 3, after assembly of the insert and the cup in the cannula, Figure 6 is a schematic top view in transparency of the spray tip, after assembly of the cup over the insert, Figure 7 is a schematic cross-sectional view of the upper end of the insert of Figures 3 to 6, Figure 8 is a view similar to that of Figure 7, showing an insert according to a second advantageous embodiment, and Figure 9 is a view similar to those of Figures 7 and 8, showing an insert according to a third advantageous embodiment.
Les termes "axial" et "radial" se réfèrent à l'axe central longitudinal A du dispositif de distribution représenté sur la figure 5. Les termes "dessus", "dessous", "supérieur" et "inférieur" se réfèrent à une position verticale telle que représentée sur les figures 3 et 5. Le terme "avant" se réfère à la direction d'écoulement du produit fluide lors de l'actionnement. The terms "axial" and "radial" refer to the longitudinal central axis A of the dispensing device shown in Figure 5. The terms "above", "below", "upper" and "lower" refer to a vertical position as shown in Figures 3 and 5. The term "forward" refers to the direction of flow of the fluid product upon actuation.
Le dispositif de distribution de produit fluide représenté sur la figure 1 comporte un réservoir 1 contenant une ou plusieurs doses de produit fluide et une tête de distribution 2 comportant une canule 3 ayant à sa partie avant 4 un orifice de distribution 5. The fluid product dispensing device shown in Figure 1 comprises a reservoir 1 containing one or more doses of fluid product and a dispensing head 2 comprising a cannula 3 having at its front part 4 a dispensing orifice 5.
Le réservoir 1 est avantageusement une seringue comportant un corps 6 et un piston (non visible dans la figure 1 ) coulissant dans ledit corps 6 lors de l'actionnement. Une tige de piston 7 est de préférence fixée au piston pour permettre à l'utilisateur d'actionner le dispositif. Cette tige de piston 7 peut comporter à son extrémité arrière une bride radiale 8 pour faciliter la préhension par un utilisateur. The reservoir 1 is advantageously a syringe comprising a body 6 and a piston (not visible in FIG. 1) sliding in said body 6 during actuation. A piston rod 7 is preferably fixed to the piston to allow the user to actuate the device. This piston rod 7 may comprise at its rear end a radial flange 8 to facilitate gripping by a user.
Le corps 6 comporte une extrémité avant ouverte adaptée à recevoir la tête de distribution 2, de préférence de manière amovible. Cette fixation de la tête de distribution 2 sur le réservoir 1 peut par exemple être réalisée via une fixation du type Luer Lock classique. D'autres moyens de fixation sont envisageables, par exemple un vissage ou un encliquetage. La canule 3 forme un tube creux définissant un canal d'expulsion de faible diamètre. Typiquement, le diamètre externe de la partie avant 4 de la canule est inférieur à 1 mm, avantageusement inférieur à 0,8 mm, de préférence environ 0,7 mm. De même, le diamètre interne de la partie avant 4 de la canule est typiquement inférieur à 0,7 mm, avantageusement inférieur à 0,5 mm, de préférence environ 0,4 mm. Dans l'exemple représenté, la canule 3 est coudée, mais elle pourrait être droite ou courbe, ou de forme quelconque appropriée. Elle peut être rigide, ou en variante partiellement ou totalement souple. Avantageusement, la partie arrière de la canule 3 est soudée à la tête de distribution 2, mais d'autre moyens de fixation sont envisageables, par exemple un emmanchage à force ou un collage. The body 6 has an open front end adapted to receive the dispensing head 2, preferably in a removable manner. This attachment of the dispensing head 2 to the reservoir 1 can for example be carried out via a conventional Luer Lock type attachment. Other attachment means are conceivable, for example screwing or snap-fastening. The cannula 3 forms a hollow tube defining a small diameter expulsion channel. Typically, the external diameter of the front part 4 of the cannula is less than 1 mm, advantageously less than 0.8 mm, preferably about 0.7 mm. Similarly, the internal diameter of the front part 4 of the cannula is typically less than 0.7 mm, advantageously less than 0.5 mm, preferably about 0.4 mm. In the example shown, the cannula 3 is bent, but it could be straight or curved, or of any suitable shape. It can be rigid, or alternatively partially or completely flexible. Advantageously, the rear part of the cannula 3 is welded to the dispensing head 2, but other fixing means are conceivable, for example a force fitting or gluing.
Selon l'invention, la canule 3 comporte un embout de pulvérisation 10.According to the invention, the cannula 3 comprises a spray tip 10.
Cet embout de pulvérisation 10 prévu dans la partie avant 4 de la canule 3 permet de réaliser la distribution du produit fluide sous forme de spray. This spray tip 10 provided in the front part 4 of the cannula 3 allows the fluid product to be distributed in the form of a spray.
Cet embout de pulvérisation 10 comporte un insert 11 qui est inséré dans la partie avant 4 de la canule 3 et une coupelle 12 disposée par-dessus l'insert 11 , également dans la partie avant 4 de la canule 3, et comportant un orifice axial formant l'orifice de distribution 5. This spray tip 10 comprises an insert 11 which is inserted into the front part 4 of the cannula 3 and a cup 12 arranged above the insert 11, also in the front part 4 of the cannula 3, and comprising an axial orifice forming the dispensing orifice 5.
L'insert 11 comporte un diamètre externe environ égal au diamètre interne de la canule 3. Avantageusement, l'insert 11 est emmanché à force dans la partie avant 4 de la canule 3. The insert 11 has an external diameter approximately equal to the internal diameter of the cannula 3. Advantageously, the insert 11 is force-fitted into the front part 4 of the cannula 3.
De même, la coupelle 12 comporte un diamètre externe environ égal au diamètre interne de la canule 3. Avantageusement, la coupelle 12 est emmanchée à force dans la partie avant 4 de la canule 3. Similarly, the cup 12 has an external diameter approximately equal to the internal diameter of the cannula 3. Advantageously, the cup 12 is force-fitted into the front part 4 of the cannula 3.
L'insert 11 comporte au moins une rainure externe 15 s'étendant sur toute la longueur axiale de l'insert, pour permettre le passage du fluide lors de l'actionnement. De préférence, ladite au moins une rainure externe 15 est axiale. En variante, ladite au moins une rainure externe 15 pourrait être non axiale, notamment oblique autour de l'insert 11 . Avantageusement, l'insert 11 comporte au moins deux rainures externes 15. La largeur de chaque rainure externe 15 est inférieure à 0,2 mm, avantageusement inférieure à 0,1 mm, de préférence environ 0,08 mm. Dans les premier et troisième modes de réalisation, représentés respectivement sur les figures 3 à 7 et sur la figure 9, il y a deux rainures externes 15 diamétralement opposées. The insert 11 comprises at least one external groove 15 extending over the entire axial length of the insert, to allow the passage of fluid during actuation. Preferably, said at least one external groove 15 is axial. Alternatively, said at least one external groove 15 could be non-axial, in particular oblique around the insert 11. Advantageously, the insert 11 comprises at least two external grooves 15. The width of each external groove 15 is less than 0.2 mm, advantageously less than 0.1 mm, preferably approximately 0.08 mm. In the first and third embodiments, shown respectively in Figures 3 to 7 and in Figure 9, there are two diametrically opposed external grooves 15.
Dans le second mode de réalisation, représenté sur la figure 8, il y a trois rainures externes 15 régulièrement réparties sur la périphérie de l'insert 11. In the second embodiment, shown in Figure 8, there are three external grooves 15 regularly distributed around the periphery of the insert 11.
A son extrémité axiale avant, l'insert 11 comporte un profil de pulvérisation pour générer un spray. Ce profil de pulvérisation comporte au moins une gorge non radiale 16, au moins une partie de paroi 17 longeant chaque gorge non radiale 16, et une chambre centrale de tourbillonnement 19 définie radialement à l'intérieur de ladite au moins une partie de paroi 17. La hauteur axiale de chaque partie de paroi 17 est inférieure à 0,15 mm, avantageusement inférieure à 0,12 mm, de préférence environ 0,1 mm. At its front axial end, the insert 11 comprises a spray profile for generating a spray. This spray profile comprises at least one non-radial groove 16, at least one wall portion 17 running along each non-radial groove 16, and a central swirl chamber 19 defined radially inside said at least one wall portion 17. The axial height of each wall portion 17 is less than 0.15 mm, advantageously less than 0.12 mm, preferably approximately 0.1 mm.
Dans les premier et troisième modes de réalisation, il y a deux gorges non radiales 16 et deux parties de paroi 17, reliant les deux rainures externes 15, comme visible sur les figures 4, 6 et 7 d'une part, et sur la figure 9 d'autre part. In the first and third embodiments, there are two non-radial grooves 16 and two wall portions 17, connecting the two external grooves 15, as visible in Figures 4, 6 and 7 on the one hand, and in Figure 9 on the other hand.
Dans le second mode de réalisation, il y a trois gorges non radiales 16 et trois parties de paroi 17, reliant les trois rainures externes 15, comme visible sur la figure 8. In the second embodiment, there are three non-radial grooves 16 and three wall portions 17, connecting the three external grooves 15, as seen in Figure 8.
La coupelle 12 comporte un manchon creux cylindrique 13 contenant un creux de forme tronconique 14 qui se rétrécie en direction de la partie avant de la coupelle 12, où le creux tronconique 14 se connecte à un creux cylindrique formant l'orifice de distribution 5. Le diamètre interne maximale du creux tronconique 14 est inférieur à 0,5 mm, avantageusement inférieur à 0,3 mm, de préférence environ 0,2 mm. Le diamètre interne de l'orifice de distribution 5 est inférieur à 0,2 mm, avantageusement inférieur à 0,1 mm, de préférence environ 0,07 mm. The cup 12 comprises a cylindrical hollow sleeve 13 containing a truncated cone-shaped recess 14 which narrows towards the front part of the cup 12, where the truncated cone-shaped recess 14 connects to a cylindrical recess forming the dispensing orifice 5. The maximum internal diameter of the truncated cone-shaped recess 14 is less than 0.5 mm, advantageously less than 0.3 mm, preferably about 0.2 mm. The internal diameter of the dispensing orifice 5 is less than 0.2 mm, advantageously less than 0.1 mm, preferably about 0.07 mm.
En position assemblée, la coupelle 12 est en contact avec l'insert 11 , en particulier avec le bord axial supérieur de chaque partie de paroi 17. In the assembled position, the cup 12 is in contact with the insert 11, in particular with the upper axial edge of each wall part 17.
Ainsi, lors de l'actionnement, le produit fluide s'écoule axialement dans la canule 3, puis axialement dans la au moins une rainure externe axiale 15, puis de manière tourbillonnante dans la chambre centrale de tourbillonnement 19, en étant guidé par la au moins une gorge non radiale 16 le long de la au moins une partie de paroi 17, ce qui fait tourbillonner le fluide dans la chambre de tourbillonnement 19 et génère un spray à travers l'orifice de distribution 5 formé dans la coupelle 12. Selon la forme de ce profil de pulvérisation, on peut modifier les propriétés du spray généré. Thus, upon actuation, the fluid product flows axially into the cannula 3, then axially into the at least one axial external groove 15, then in a swirling manner in the central swirl chamber 19, being guided by the at least one non-radial groove 16 along the at least one wall portion 17, which swirls the fluid in the swirl chamber 19 and generates a spray through the dispensing orifice 5 formed in the cup 12. Depending on the shape of this spray profile, the properties of the spray generated can be modified.
Avantageusement, l'insert 11 et la coupelle 12 sont en totalité disposés à l'intérieur de la partie avant 4 de la canule 3, de sorte que la présence de l'embout de pulvérisation 10 n'augmente pas le diamètre externe de la canule, et ne modifie pas son utilisation. Advantageously, the insert 11 and the cup 12 are entirely arranged inside the front part 4 of the cannula 3, so that the presence of the spray tip 10 does not increase the external diameter of the cannula, and does not modify its use.
Des tests des modes de réalisation des figures 7 à 9 ont permis d'établir : Tests of the embodiments of Figures 7 to 9 have made it possible to establish:
- l'invention permet de générer un spray correct, en se basant d'une part sur la géométrie et la vélocité du spray, et d'autre part sur la granulométrie des gouttes de spray (DSD: "Drop Size Distribution"); ainsi, les trois modes de réalisation décrits ci-dessus permettent d'obtenir un Dv50 inférieur à 30 pm; - the invention makes it possible to generate a correct spray, based on the one hand on the geometry and velocity of the spray, and on the other hand on the granulometry of the spray drops (DSD: "Drop Size Distribution"); thus, the three embodiments described above make it possible to obtain a Dv50 of less than 30 pm;
- le premier mode de réalisation présente des propriétés de spray particulièrement bonnes, avec un Dv50 moyen inférieur ou égal à 20 pm. - the first embodiment has particularly good spray properties, with an average Dv50 less than or equal to 20 pm.
Un fonctionnement préféré du dispositif représenté sur la figure 1 va maintenant être décrit. A preferred operation of the device shown in Figure 1 will now be described.
Avant la première utilisation, le réservoir 1 peut être vide et séparé de la tête de distribution 2. Il est alors de préférence fermé par un bouchon (non représenté), de manière connue. Before the first use, the tank 1 can be empty and separated from the dispensing head 2. It is then preferably closed by a cap (not shown), in a known manner.
L'utilisateur qui souhaite utiliser le dispositif retire le bouchon du réservoir 1 et remplit celui-ci avec du produit fluide. Par exemple, dans le cas d'une seringue, il aspire du produit fluide à partir d'une réserve de produit fluide, en tirant le piston vers l'arrière dans le corps 6. Le réservoir 1 peut être rempli avec une dose de volume choisi, ou en variante avec deux ou plusieurs doses. The user who wishes to use the device removes the cap from the reservoir 1 and fills it with fluid product. For example, in the case of a syringe, he draws fluid product from a fluid product reserve, by pulling the piston backwards in the body 6. The reservoir 1 can be filled with a dose of chosen volume, or alternatively with two or more doses.
Le dispositif est alors prêt pour sa première utilisation active, pour distribuer une dose de produit fluide. Lorsque l'utilisateur appuie sur la tige de piston 7, il déplace le piston par rapport au corps 6. Du produit fluide contenu dans le réservoir 1 est alors expulsé dans la canule 3 puis pulvérisé par l'embout de pulvérisation 10. The device is then ready for its first active use, to dispense a dose of fluid product. When the user presses the piston rod 7, he moves the piston relative to the body 6. Fluid product contained in the reservoir 1 is then expelled into the cannula 3 and then sprayed by the spray tip 10.
Avantageusement, la totalité du produit fluide contenu dans le réservoir 1 est distribuée en un seul actionnement. Advantageously, all of the fluid product contained in the reservoir 1 is dispensed in a single actuation.
En variante, le contenu du réservoir peut être distribué en deux ou plusieurs actionnements successifs. Alternatively, the contents of the tank may be dispensed in two or more successive actuations.
Lorsque le réservoir 1 est vide, l'utilisateur peut retirer la tête de distribution 2, et remplir à nouveau le réservoir 1 de manière connue pour une prochaine utilisation du dispositif. When the tank 1 is empty, the user can remove the dispensing head 2, and refill the tank 1 in a known manner for the next use of the device.
Il est à noter que l'embout de pulvérisation 10 décrit ci-dessus pourrait aussi être utilisé avec un réservoir prérempli et/ou un dispositif à usage unique jetable après utilisation. It should be noted that the spray tip 10 described above could also be used with a pre-filled reservoir and/or a single-use device disposable after use.
Une application préférée de la présente invention concerne l'administration de produit pharmaceutique à des petits animaux, tels que par exemple des souris. Une application chez l'homme est toutefois aussi envisageable. A preferred application of the present invention relates to the administration of pharmaceutical product to small animals, such as for example mice. An application in humans is however also conceivable.
Bien que la présente invention ait été décrite en référence à des modes de réalisation avantageux, il est entendu que l’homme du métier peut y apporter diverses modifications sans sortir du cadre de la présente invention tel que défini par les revendications annexées. Although the present invention has been described with reference to advantageous embodiments, it is understood that those skilled in the art can make various modifications thereto without departing from the scope of the present invention as defined by the appended claims.
Claims
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FRFR2301968 | 2023-03-02 | ||
| FR2301968A FR3146289B1 (en) | 2023-03-02 | 2023-03-02 | Fluid product dispensing device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2024180304A1 true WO2024180304A1 (en) | 2024-09-06 |
Family
ID=86657480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/FR2024/050261 Pending WO2024180304A1 (en) | 2023-03-02 | 2024-03-01 | Device for dispensing a fluid product |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR3146289B1 (en) |
| WO (1) | WO2024180304A1 (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1136942A (en) * | 1955-10-21 | 1957-05-21 | Cannula tip for injections | |
| US5605255A (en) | 1994-06-28 | 1997-02-25 | Behringwerke Aktiengesellschaft | Apparatus for spraying a mixture of two components |
| WO1997046324A1 (en) | 1996-06-01 | 1997-12-11 | Alfred Von Schuckmann | Fluid dispenser |
| US20150273486A1 (en) | 2012-10-31 | 2015-10-01 | Yoshino Kogyosho Co., Ltd. | Ejection head and container provided with the same |
| WO2019086272A1 (en) | 2017-11-06 | 2019-05-09 | Lindal France Sas | Two-piece nozzle for aerosol dispensers |
-
2023
- 2023-03-02 FR FR2301968A patent/FR3146289B1/en active Active
-
2024
- 2024-03-01 WO PCT/FR2024/050261 patent/WO2024180304A1/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1136942A (en) * | 1955-10-21 | 1957-05-21 | Cannula tip for injections | |
| US5605255A (en) | 1994-06-28 | 1997-02-25 | Behringwerke Aktiengesellschaft | Apparatus for spraying a mixture of two components |
| WO1997046324A1 (en) | 1996-06-01 | 1997-12-11 | Alfred Von Schuckmann | Fluid dispenser |
| US20150273486A1 (en) | 2012-10-31 | 2015-10-01 | Yoshino Kogyosho Co., Ltd. | Ejection head and container provided with the same |
| WO2019086272A1 (en) | 2017-11-06 | 2019-05-09 | Lindal France Sas | Two-piece nozzle for aerosol dispensers |
Also Published As
| Publication number | Publication date |
|---|---|
| FR3146289B1 (en) | 2025-08-22 |
| FR3146289A1 (en) | 2024-09-06 |
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