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WO2024178251A3 - System and method to modulate arousal or reduce delirium severity - Google Patents

System and method to modulate arousal or reduce delirium severity Download PDF

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Publication number
WO2024178251A3
WO2024178251A3 PCT/US2024/016946 US2024016946W WO2024178251A3 WO 2024178251 A3 WO2024178251 A3 WO 2024178251A3 US 2024016946 W US2024016946 W US 2024016946W WO 2024178251 A3 WO2024178251 A3 WO 2024178251A3
Authority
WO
WIPO (PCT)
Prior art keywords
neurostimulation
vagus nerve
signals
systems
arousal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2024/016946
Other languages
French (fr)
Other versions
WO2024178251A2 (en
Inventor
Patrick PURDON
Vitaly Napadow
Ronald Garcia
Alessandra ANZOLIN
Proloy DAS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of WO2024178251A2 publication Critical patent/WO2024178251A2/en
Publication of WO2024178251A3 publication Critical patent/WO2024178251A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36031—Control systems using physiological parameters for adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36034—Control systems specified by the stimulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Physiology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Developmental Disabilities (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Social Psychology (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Electrotherapy Devices (AREA)

Abstract

Systems and methods are described for neurostimulation to provide therapeutic outcomes, such as the treatment of delirium, disorders of consciousness, narcolepsy, and inflammatory disorders, with signals that are adjusted based on electroencephalographic (EEG) signals. The neurostimulation may target the vagus nerve or its branches. The systems and methods use a detecting device to detect EEG characteristics where central autonomic nuclei may be more receptive to afferent input from the vagus nerve. A stimulator is controlled to provide neurostimulation to the auricular branch of a vagus nerve of the subject.
PCT/US2024/016946 2023-02-22 2024-02-22 System and method to modulate arousal or reduce delirium severity Ceased WO2024178251A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363486259P 2023-02-22 2023-02-22
US63/486,259 2023-02-22

Publications (2)

Publication Number Publication Date
WO2024178251A2 WO2024178251A2 (en) 2024-08-29
WO2024178251A3 true WO2024178251A3 (en) 2024-10-31

Family

ID=92501805

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/016946 Ceased WO2024178251A2 (en) 2023-02-22 2024-02-22 System and method to modulate arousal or reduce delirium severity

Country Status (1)

Country Link
WO (1) WO2024178251A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119034070B (en) * 2024-11-04 2025-03-04 首都医科大学宣武医院 Electrical stimulation awakening treatment system and equipment based on unsupervised learning model

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090076561A1 (en) * 2007-09-13 2009-03-19 Cardiac Pacemakers, Inc. Systems and methods for avoiding neural stimulation habituation
US20160067497A1 (en) * 2009-11-17 2016-03-10 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
US20160279021A1 (en) * 2015-03-27 2016-09-29 Elwha Llc Vibratory ear stimulation system and method
US20180333558A1 (en) * 2017-05-18 2018-11-22 Advanced Brain Monitoring, Inc. Systems and methods for detecting and managing physiological patterns
US20200046976A1 (en) * 2010-08-19 2020-02-13 Electrocore, Inc. Non-invasive treatment of neurodegenerative diseases
US20200222699A1 (en) * 2017-07-17 2020-07-16 Sri International Slow wave activity optimization based on dominant peripheral nervous system oscillations
US20200390997A1 (en) * 2016-05-26 2020-12-17 Emil Jovanov Systems and Methods for Multi-Modal and Non-Invasive Stimulation of the Nervous System
US20210370064A1 (en) * 2020-05-27 2021-12-02 Attune Neurosciences, Inc. Ultrasound Systems and Associated Devices and Methods for Modulating Brain Activity

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090076561A1 (en) * 2007-09-13 2009-03-19 Cardiac Pacemakers, Inc. Systems and methods for avoiding neural stimulation habituation
US20160067497A1 (en) * 2009-11-17 2016-03-10 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
US20200046976A1 (en) * 2010-08-19 2020-02-13 Electrocore, Inc. Non-invasive treatment of neurodegenerative diseases
US20160279021A1 (en) * 2015-03-27 2016-09-29 Elwha Llc Vibratory ear stimulation system and method
US20200390997A1 (en) * 2016-05-26 2020-12-17 Emil Jovanov Systems and Methods for Multi-Modal and Non-Invasive Stimulation of the Nervous System
US20180333558A1 (en) * 2017-05-18 2018-11-22 Advanced Brain Monitoring, Inc. Systems and methods for detecting and managing physiological patterns
US20200222699A1 (en) * 2017-07-17 2020-07-16 Sri International Slow wave activity optimization based on dominant peripheral nervous system oscillations
US20210370064A1 (en) * 2020-05-27 2021-12-02 Attune Neurosciences, Inc. Ultrasound Systems and Associated Devices and Methods for Modulating Brain Activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DE FREITAS DAGLIE, DE CARVALHO DANIEL, PAGLIONI VANESSA MARIA, BRUNONI ANDRE R, VALIENGO LEANDRO, THOME-SOUZA MARIA SIGRIDE, GUIRA: "Effects of transcranial direct current stimulation (tDCS) and concurrent cognitive training on episodic memory in patients with traumatic brain injury: a double-blind, randomised, placebo-controlled study", BMJ OPEN, BMJ PUBLISHING GROUP, LONDON, UK, vol. 11, no. 8, 17 June 2021 (2021-06-17), London, UK , pages e045285, XP093231743, ISSN: 2044-6055, DOI: 10.1136/bmjopen-2020-045285 *

Also Published As

Publication number Publication date
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