WO2024178051A3 - Tryptamine derivatives - Google Patents
Tryptamine derivatives Download PDFInfo
- Publication number
- WO2024178051A3 WO2024178051A3 PCT/US2024/016630 US2024016630W WO2024178051A3 WO 2024178051 A3 WO2024178051 A3 WO 2024178051A3 US 2024016630 W US2024016630 W US 2024016630W WO 2024178051 A3 WO2024178051 A3 WO 2024178051A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- benzyloxy
- chloride
- crystalline
- acetamide
- indole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
This disclosure relates to 2-[4-(benzyloxy)-lH-indol-3-yl]-2-oxo-A/-(propan-2-yl)acetamide (A/-2-propyl-a-oxo-4-(phenylmethoxy)-lH-indole-3-acetamide), crystalline A/-2-propyl-a-oxo-4-(phenylmethoxy)-lH- indole-3-acetamide, 4-phenoxy-lH-indole (4-benzyloxyindole), crystalline 4-benzyloxyindole, {2-[4- (benzyloxy)-lH-indol-3-yl]ethyl}(propan-2-yl)azanium chloride (4-benzyloxy-/V-isopropyltryptammonium chloride or 4-benzyloxy-NiPT chloride), crystalline 4-benzyloxy-NiPT chloride, and specific crystalline forms thereof, such as crystalline form 1 of /V-2-propyl-a-oxo-4-(phenylmethoxy)-lH-indole-3 acetamide, crystalline form 1 of 4-benzyloxyindole, and crystalline form 1 of 4-benzyloxy-NiPT chloride, to compositions containing the same, and to method of treatment using them.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202363486295P | 2023-02-22 | 2023-02-22 | |
| US202363486292P | 2023-02-22 | 2023-02-22 | |
| US202363486297P | 2023-02-22 | 2023-02-22 | |
| US63/486,292 | 2023-02-22 | ||
| US63/486,295 | 2023-02-22 | ||
| US63/486,297 | 2023-02-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2024178051A2 WO2024178051A2 (en) | 2024-08-29 |
| WO2024178051A3 true WO2024178051A3 (en) | 2024-10-17 |
Family
ID=92501782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2024/016630 Pending WO2024178051A2 (en) | 2023-02-22 | 2024-02-21 | Tryptamine derivatives |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2024178051A2 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210145851A1 (en) * | 2019-11-19 | 2021-05-20 | Paul Edward Stamets | Tryptamine compositions for enhancing neurite outgrowth |
| WO2021179091A1 (en) * | 2020-03-12 | 2021-09-16 | Bright Minds Biosciences Inc. | 3-(2-(aminoethyl)-indol-4-ol derivatives, methods of preparation thereof, and the use as 5-ht2 receptor modulators |
| US20210403425A1 (en) * | 2020-06-30 | 2021-12-30 | Field Trip Psychedelics Inc. | Tryptamine prodrugs |
-
2024
- 2024-02-21 WO PCT/US2024/016630 patent/WO2024178051A2/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210145851A1 (en) * | 2019-11-19 | 2021-05-20 | Paul Edward Stamets | Tryptamine compositions for enhancing neurite outgrowth |
| WO2021179091A1 (en) * | 2020-03-12 | 2021-09-16 | Bright Minds Biosciences Inc. | 3-(2-(aminoethyl)-indol-4-ol derivatives, methods of preparation thereof, and the use as 5-ht2 receptor modulators |
| US20210403425A1 (en) * | 2020-06-30 | 2021-12-30 | Field Trip Psychedelics Inc. | Tryptamine prodrugs |
Non-Patent Citations (2)
| Title |
|---|
| "Hallucinogens : Neurochemical, behavioral, and clinical perspectives", 1 January 1984, RAVEN PRESS, US, ISBN: 0-89004-990-4, article DAVID E. NICHOLS, RICHARD A. GLENNON: "Medicinal Chemistry and Structure Activity Relationships of Hallucinogens", pages: 95 - 142, XP009558307 * |
| LABAN UROŠ, NAEEM MARILYN, CHADEAYNE ANDREW R., GOLEN JAMES A., MANKE DAVID R.: "Synthesis and structure of 4-hydroxy- N -isopropyltryptamine (4-HO-NiPT) and its precursors", ACTA CRYSTALLOGRAPHICA, vol. E79, 1 April 2023 (2023-04-01), pages 280 - 286+24, XP093224882, ISSN: 2056-9890, DOI: 10.1107/S2056989023002098 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2024178051A2 (en) | 2024-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NENP | Non-entry into the national phase |
Ref country code: DE |