[go: up one dir, main page]

WO2024177975A3 - Cellules d'engagement de tim3 - Google Patents

Cellules d'engagement de tim3 Download PDF

Info

Publication number
WO2024177975A3
WO2024177975A3 PCT/US2024/016477 US2024016477W WO2024177975A3 WO 2024177975 A3 WO2024177975 A3 WO 2024177975A3 US 2024016477 W US2024016477 W US 2024016477W WO 2024177975 A3 WO2024177975 A3 WO 2024177975A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
tim3
engager
engagement function
type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2024/016477
Other languages
English (en)
Other versions
WO2024177975A2 (fr
Inventor
Tobias Deuse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
Publication of WO2024177975A2 publication Critical patent/WO2024177975A2/fr
Publication of WO2024177975A3 publication Critical patent/WO2024177975A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des cellules qui ont une fonction d'engagement de TIM3 accrue. Les cellules atténuent l'immunité adaptative et innée lorsqu'elles sont transplantées chez un sujet par comparaison avec une cellule parentale dotée d'une fonction d'engagement de TIM3 non modifiée correspondante. Dans certains modes de réalisation, les cellules d'engagement de TIM3 sont des cellules pluripotentes, différenciées et/ou des cellules hypoimmunitaires. Dans d'autres modes de réalisation, les cellules sont de groupe sanguin O, de facteur Rhesus (Rh) négatif, ou à la fois de groupe O et de facteur Rh-. Dans d'autres modes de réalisation, les cellules d'engagement de TIM3 en ont été dérivées.
PCT/US2024/016477 2023-02-24 2024-02-20 Cellules d'engagement de tim3 Ceased WO2024177975A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202363448091P 2023-02-24 2023-02-24
US63/448,091 2023-02-24
US202363544590P 2023-10-17 2023-10-17
US202363544588P 2023-10-17 2023-10-17
US63/544,590 2023-10-17
US63/544,588 2023-10-17

Publications (2)

Publication Number Publication Date
WO2024177975A2 WO2024177975A2 (fr) 2024-08-29
WO2024177975A3 true WO2024177975A3 (fr) 2024-11-14

Family

ID=92501759

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/016477 Ceased WO2024177975A2 (fr) 2023-02-24 2024-02-20 Cellules d'engagement de tim3

Country Status (1)

Country Link
WO (1) WO2024177975A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150093366A1 (en) * 2010-12-09 2015-04-02 Galpharma Co., Ltd. Galectin-9-secreting cell, and production method and use of the same
WO2022125439A2 (fr) * 2020-12-07 2022-06-16 The Regents Of The University Of California Silençage de cellules immunitaires innées par un engageur sirp-alpha
US20220235130A1 (en) * 2021-01-28 2022-07-28 Nantbio, Inc. Anti-TIM3 monoclonal antibodies and chimeric antigen receptors
WO2023167575A1 (fr) * 2022-03-04 2023-09-07 주식회사 툴젠 Cellules souches faiblement immunogènes, cellules faiblement immunogènes différenciées ou dérivées de cellules souches, et leur procédé de production

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150093366A1 (en) * 2010-12-09 2015-04-02 Galpharma Co., Ltd. Galectin-9-secreting cell, and production method and use of the same
WO2022125439A2 (fr) * 2020-12-07 2022-06-16 The Regents Of The University Of California Silençage de cellules immunitaires innées par un engageur sirp-alpha
US20220235130A1 (en) * 2021-01-28 2022-07-28 Nantbio, Inc. Anti-TIM3 monoclonal antibodies and chimeric antigen receptors
WO2023167575A1 (fr) * 2022-03-04 2023-09-07 주식회사 툴젠 Cellules souches faiblement immunogènes, cellules faiblement immunogènes différenciées ou dérivées de cellules souches, et leur procédé de production

Also Published As

Publication number Publication date
WO2024177975A2 (fr) 2024-08-29

Similar Documents

Publication Publication Date Title
Ke et al. Optimal learning before choice
WO2021034696A8 (fr) Cellules électrochimiques comprenant des espèces contenant un groupe thiol
MY187822A (en) Method of preparing cathode for secondary battery
WO2004036677A8 (fr) Systeme electrochimique
WO2022125439A3 (fr) Silençage de cellules immunitaires innées par un engageur sirp-alpha
NZ712789A (en) Placental stem cell populations
WO2023167859A3 (fr) Couches de transport poreuses pour cellules électrochimiques
WO2006012597A3 (fr) Procede pour enrichir une population de spermatozoides
WO2024177975A3 (fr) Cellules d'engagement de tim3
Björck et al. Relative sea level changes and glacio-isostatic modelling in the Beagle Channel, Tierra del Fuego, Chile: Glacial and tectonic implications
Lauinger et al. Polyoxometalate multielectron catalysts in solar fuel production
AR046887A1 (es) Celda alcalina de alta capacidad utilizando un extensor de catodo
WO2024177982A3 (fr) Cellules d'activation de lilrb1
Boffa et al. Aggregation operators on shadowed sets
CN102497462A (zh) 移动终端
Mohamed et al. The Impact of Charlson Comorbidity Index on De Novo Cardiac Implantable Electronic Device Procedural Outcomes in the United States
CN200990393Y (zh) 电池壳体以及由该电池壳体制成的电池
Noymer et al. Divergence without decoupling: Male and female life expectancy usually co-move
MY201528A (en) Lead-acid battery
WO2005070039A3 (fr) Materiau actif d'electrode positive pour electrode de nickel
EP3068145A1 (fr) Appareil auditif
CN202491803U (zh) 罩式货车车厢的门扇
WO2019202161A3 (fr) Réacteur de précipitation électrochimique comprenant une électrode en mouvement
CN204878479U (zh) 一种增强型车用板簧
CN208127260U (zh) 一种弹性电池盒结构及放大镜

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE