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WO2024174124A1 - Méthode et appareil de surveillance de pression artérielle sans contact basés sur des ondes d'impulsion multispectrales - Google Patents

Méthode et appareil de surveillance de pression artérielle sans contact basés sur des ondes d'impulsion multispectrales Download PDF

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Publication number
WO2024174124A1
WO2024174124A1 PCT/CN2023/077639 CN2023077639W WO2024174124A1 WO 2024174124 A1 WO2024174124 A1 WO 2024174124A1 CN 2023077639 W CN2023077639 W CN 2023077639W WO 2024174124 A1 WO2024174124 A1 WO 2024174124A1
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WO
WIPO (PCT)
Prior art keywords
pulse wave
blood pressure
spectral
signals
pressure monitoring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2023/077639
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English (en)
Chinese (zh)
Inventor
王文锦
徐永
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Ibaby Labs Inc
Southern University of Science and Technology
Original Assignee
Shenzhen Ibaby Labs Inc
Southern University of Science and Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenzhen Ibaby Labs Inc, Southern University of Science and Technology filed Critical Shenzhen Ibaby Labs Inc
Priority to PCT/CN2023/077639 priority Critical patent/WO2024174124A1/fr
Publication of WO2024174124A1 publication Critical patent/WO2024174124A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels

Definitions

  • the present invention relates to the technical field of non-contact heart rate measurement, and in particular to a non-contact blood pressure monitoring method and device based on multi-spectral pulse wave.
  • Camera-PPG-based video sensing technology has been used for non-contact vital sign monitoring and health monitoring, using image/signal processing algorithms to extract human physiological signals from a video image containing continuous frames.
  • the methods of video monitoring of heart rate and respiratory rate are relatively mature, while the research and application of blood pressure monitoring are relatively few, mainly because of the high complexity of its technical implementation.
  • the research on non-contact camera-PPG signal monitoring of blood pressure can be divided into two categories: (i) based on the characteristics of pulse transit time (PTT).
  • PTT pulse transit time
  • the pulse transit time can be calculated by the time difference between the R peak of the ECG electrocardiogram and the systolic peak of the contact PPG of the fingertips.
  • the purpose of the present invention is to provide a non-contact blood pressure monitoring method and device based on multi-spectral pulse wave to solve the problems mentioned in the above background technology.
  • the solution of the present invention is: a non-contact blood pressure monitoring method based on multi-spectral pulse wave, comprising:
  • the multi-spectral optical imaging device includes a light source transmitter and a camera; a polarizer 1 is arranged in front of the light source transmitter; a camera sensor is arranged on the camera, and a polarizer 2 perpendicular to the polarization direction of the light source is arranged in front of the camera sensor.
  • the light source emitter is a Phosphor LED light source with a continuous broadband spectrum.
  • the camera sensor is an RGB camera sensor and a NIR sensor.
  • the multiple band signals extracted from the pixels of the skin area are B-G-IR three-channel time domain signals
  • the three bands in the B-G-IR are B (450 nm ⁇ 10 nm) - G (550 nm ⁇ 10 nm) - IR (805 nm ⁇ 10 nm); after simple detrending and bandpass filtering, the B-G-IR three-channel time domain signal removes non-pulse wave components in the signal to generate a three-channel pulse wave signal.
  • the pulse wave signal in the green light band represents the blood pulsation volume in the arterioles.
  • the pulse wave signal in the near-infrared light band represents the blood pulsation volume in the artery.
  • the systolic peaks of the pulse wave signals in the green light band and the near-infrared light band are detected to calculate the systolic peak spacing of the pulse wave signals in different bands in the same cardiac cycle, and the calculated peak spacing is the pulse wave conduction time.
  • a non-contact blood pressure monitoring device based on multi-spectral pulse wave comprising:
  • Multispectral optical imaging equipment for collecting and acquiring continuous video images including human skin
  • a multi-spectral pulse wave signal extraction module is used to extract pulse wave signals of multiple bands in the skin pixel in the time domain;
  • the pulse wave signal noise reduction and separation module uses the pulse wave signal in the blue light band of the multi-spectral pulse wave signal to reduce noise and decompose the pulse wave signals in the green light band and the near-infrared light band;
  • a pulse wave transmission time estimation module is used to extract the pulse wave transmission time from the decomposed green light and near-infrared light pulse wave signals
  • the blood pressure calibration module is used to calibrate the extracted pulse wave transmission time, obtain the calibrated regression model parameters, and generate continuous dynamic estimation values of blood pressure.
  • the device also includes a UI display interface for displaying the monitoring video and the blood pressure values obtained through monitoring.
  • the present invention uses a single camera to obtain continuous video images of human skin, so that the obtained images can be used to extract pulse wave signal data in visible light and near-infrared at the same time, which significantly enhances the independence of different bands in pulse wave signal monitoring. Then, the systolic peak spacing of pulse wave signals of different bands in the same cardiac cycle is calculated through the extracted pulse wave signal data, and the pulse wave conduction time is obtained, so that a regression model can be established through the pulse wave conduction time and blood pressure, and the continuous dynamic estimation of blood pressure parameters can be calibrated to obtain more accurate blood pressure data; and the use of multi-spectral pulse wave signals can suppress motion interference and environmental noise that occur during monitoring, further improving the accuracy of monitoring.
  • Fig. 1 is a flow chart of the method of the present invention
  • FIG. 2 is a structural block diagram of the blood pressure monitoring device of the present invention.
  • a non-contact blood pressure monitoring method based on multi-spectral pulse wave includes:
  • the multi-spectral optical imaging device includes a light source transmitter and a camera; a polarizer 1 is provided in front of the light source transmitter; a camera sensor is provided on the camera, and a polarizer 2 perpendicular to the polarization direction of the light source is provided in front of the camera sensor;
  • the light source transmitter is a Phosphor LED light source with a continuous broadband spectrum;
  • the camera sensor is an RGB camera sensor and a NIR sensor; in this embodiment, the multiple band signals extracted from the pixels of the skin area are B-G-IR three-channel time domain signals, and the three bands in the B-G-IR are B (450 nm ⁇ 10 nm) - G (550 nm ⁇ 10 nm) - IR (805 nm ⁇ 10
  • the polarized photons emitted by the light source are absorbed and scattered by the skin tissue and then reflected and can pass through the polarizer 2 on one side of the camera.
  • This process is a depolarization process, which will prevent the specular reflection light that has not entered the skin tissue from passing through, so that the polarized light can ensure that the video mainly monitors the diffuse reflection signal containing physiological information from the skin tissue layer; in this embodiment, the polarizer 1 of the light source transmitter is 0°, and the polarizer 2 of the camera sensor is 90°.
  • Such a setting can make the polarization direction of the polarizer vertical, thereby achieving the purpose of suppressing the specular reflection of the skin and ensuring the clarity of the shooting; and the polarizer 2 at the camera sensor can change the vibration direction of the light, and the three-band narrowband filter of the camera sensor will force the camera's shooting channel from the R-G-B channel to the narrowband B-G-IR channel, specifically using B (450 nm ⁇ 10 nm) - G (550 nm ⁇ 10 nm) - IR (805 nm ⁇ 10
  • the use of narrow bands can enhance the independence between bands and strengthen the perception of physiological information of different tissue layers, so that a single camera can simultaneously obtain images in visible light and near-infrared.
  • the B-G-IR three-channel time domain signal can effectively reduce noise infection, ensuring accurate and stable transmission of signals.
  • the pulse wave signal of the blue light band in the multi-spectral pulse wave signal to reduce noise and decompose the pulse wave signals of the green light band and the near-infrared light band, and then extract the pulse wave transmission time from the decomposed green light and near-infrared light pulse wave signals;
  • the pulse wave signal of the green light band represents the blood pulsation volume in the arterioles;
  • the pulse wave signal of the near-infrared light band represents the blood pulsation volume in the arteries; in this embodiment, the decomposed green light and near-infrared light
  • the systolic peaks of the pulse wave signals in the green light band and the near-infrared light band are detected to calculate the systolic peak spacing of the pulse wave signals in different bands in the same cardiac cycle.
  • the calculated peak spacing is the pulse wave transmission time.
  • the pulse wave signal in the blue light band is used as the reference signal.
  • the photons of the pulse wave signal in the blue light band can only reach the subcutaneous ⁇ 0.5 mm, which mainly senses the physiological information of the epidermis (i.e., the mechanical compression of capillaries by arterial pulsation), so it can remove the interference of non-pulsating blood in the superficial skin tissue in the pulse wave signals of the green light band and the near-infrared light band, making the pulse wave signals of the green light band and the near-infrared light band purer; and the extracted pulse wave transmission time is calculated by the peak detection algorithm, by detecting the systolic peaks of the pulse wave signals of the green light band and the near-infrared light band, the systolic peak spacing (i.e., PTT characteristics) of the pulse wave signals of different bands in the same cardiac
  • systolic pressure, diastolic pressure, and average blood pressure are obtained from the user's standard monitor, and the blood pressure calibration model extracts features from multi-spectral polarized light signals and maps them to blood pressure values through the model, so that the calibrated continuous dynamic estimation data also includes systolic pressure, diastolic pressure, and average blood pressure, and finally accurate systolic pressure, diastolic pressure, and average blood pressure values are obtained.
  • a non-contact blood pressure monitoring device based on multi-spectral pulse wave comprising:
  • Multispectral optical imaging equipment for collecting and acquiring continuous video images including human skin
  • a multi-spectral pulse wave signal extraction module is used to extract pulse wave signals of multiple bands in the skin pixel in the time domain;
  • the pulse wave signal noise reduction and separation module uses the pulse wave signal in the blue light band of the multi-spectral pulse wave signal to reduce noise and decompose the pulse wave signals in the green light band and the near-infrared light band;
  • a pulse wave transmission time estimation module is used to extract the pulse wave transmission time from the decomposed green light and near-infrared light pulse wave signals
  • the blood pressure calibration module is used to calibrate the extracted pulse wave transmission time, obtain the calibrated regression model parameters, and generate continuous dynamic estimation values of blood pressure.
  • the device further includes a UI display interface for displaying the monitoring video and the blood pressure value obtained by monitoring;
  • the present invention provides a non-contact blood pressure monitoring method and device based on multi-spectral pulse wave, which uses a single camera to obtain continuous video images of human skin, so that the obtained image can simultaneously extract pulse wave signal data in visible light and near-infrared, significantly enhancing the independence of different bands in pulse wave signal monitoring, and then calculating the systolic peak spacing of pulse wave signals of different bands in the same cardiac cycle through the extracted pulse wave signal data, and obtaining the pulse wave conduction time, so as to establish a regression model through the pulse wave conduction time and blood pressure, calibrate the continuous dynamic estimation of blood pressure parameters, and obtain more accurate blood pressure data; and the use of multi-spectral pulse wave signals can suppress motion interference and environmental noise occurring in monitoring, further improving the accuracy of monitoring.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

La présente invention divulgue une méthode et un appareil de surveillance de pression artérielle sans contact basés sur des ondes d'impulsion multispectrales. La méthode comprend les étapes comprenant : S1, l'acquisition d'une image vidéo continue contenant de la peau humaine, la sélection d'une région de peau efficace dans l'image vidéo, et l'extraction de signaux d'onde d'impulsion à partir de pixels de la région de peau ; S2, la réalisation d'un débruitage et d'une décomposition en composantes sur des signaux d'onde d'impulsion d'une bande d'onde de lumière verte et d'une bande d'onde de lumière proche infrarouge à l'aide d'un signal d'onde d'impulsion d'une bande d'onde de lumière bleue parmi des signaux d'onde d'impulsion multispectrale, et l'extraction d'un temps de transit d'onde d'impulsion ; et S3, l'établissement d'un modèle de régression concernant le temps de transit d'onde d'impulsion et une pression artérielle, et l'étalonnage et l'estimation continue et dynamique de la pression artérielle. Dans la présente invention, une seule caméra est utilisée pour acquérir une image vidéo continue de la peau humaine, de sorte que l'extraction de signaux d'onde d'impulsion en lumière visible et dans l'infrarouge proche à partir de l'image peut être réalisée simultanément, ce qui permet d'améliorer significativement l'indépendance de différentes bandes d'onde dans la surveillance de signal d'onde d'impulsion, et après qu'un modèle de régression est établi à l'aide d'un temps de transit d'onde d'impulsion calculé, des paramètres de pression artérielle peuvent être étalonnés, ce qui permet d'assurer la précision des valeurs de pression artérielle.
PCT/CN2023/077639 2023-02-22 2023-02-22 Méthode et appareil de surveillance de pression artérielle sans contact basés sur des ondes d'impulsion multispectrales Ceased WO2024174124A1 (fr)

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PCT/CN2023/077639 WO2024174124A1 (fr) 2023-02-22 2023-02-22 Méthode et appareil de surveillance de pression artérielle sans contact basés sur des ondes d'impulsion multispectrales

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PCT/CN2023/077639 WO2024174124A1 (fr) 2023-02-22 2023-02-22 Méthode et appareil de surveillance de pression artérielle sans contact basés sur des ondes d'impulsion multispectrales

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120585298A (zh) * 2025-08-04 2025-09-05 晟命医疗科技(杭州)有限公司 一种非接触式血液光谱成像血压监测系统及方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108778105A (zh) * 2015-12-22 2018-11-09 香港中文大学 基于多波长光电容积描记法测量心血管和呼吸参数的方法
CN111295133A (zh) * 2017-11-01 2020-06-16 皇家飞利浦有限公司 用于确定对象的至少一个生命体征的设备、系统和方法
US20210059585A1 (en) * 2019-08-26 2021-03-04 nanoLambda Korea On-chip integrated multi-wavelengths biological sensing device
WO2021100994A1 (fr) * 2019-11-21 2021-05-27 주식회사 지비소프트 Procédé sans contact pour la mesure d'un indice biologique
WO2022182156A1 (fr) * 2021-02-25 2022-09-01 주식회사 지비소프트 Procédé permettant de mesurer des indices physiologiques

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108778105A (zh) * 2015-12-22 2018-11-09 香港中文大学 基于多波长光电容积描记法测量心血管和呼吸参数的方法
CN111295133A (zh) * 2017-11-01 2020-06-16 皇家飞利浦有限公司 用于确定对象的至少一个生命体征的设备、系统和方法
US20210059585A1 (en) * 2019-08-26 2021-03-04 nanoLambda Korea On-chip integrated multi-wavelengths biological sensing device
WO2021100994A1 (fr) * 2019-11-21 2021-05-27 주식회사 지비소프트 Procédé sans contact pour la mesure d'un indice biologique
WO2022182156A1 (fr) * 2021-02-25 2022-09-01 주식회사 지비소프트 Procédé permettant de mesurer des indices physiologiques

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120585298A (zh) * 2025-08-04 2025-09-05 晟命医疗科技(杭州)有限公司 一种非接触式血液光谱成像血压监测系统及方法

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