[go: up one dir, main page]

WO2024169774A3 - Analogues nucléosidiques et de nucléotidiques, leurs procédés de fabrication et leurs procédés d'utilisation - Google Patents

Analogues nucléosidiques et de nucléotidiques, leurs procédés de fabrication et leurs procédés d'utilisation Download PDF

Info

Publication number
WO2024169774A3
WO2024169774A3 PCT/CN2024/076229 CN2024076229W WO2024169774A3 WO 2024169774 A3 WO2024169774 A3 WO 2024169774A3 CN 2024076229 W CN2024076229 W CN 2024076229W WO 2024169774 A3 WO2024169774 A3 WO 2024169774A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
nucleoside
nucleotide analogs
making
isomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2024/076229
Other languages
English (en)
Other versions
WO2024169774A2 (fr
Inventor
Jinzi Jason Wu
Junxing Shi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ascletis Bioscience Co Ltd
Original Assignee
Ascletis Bioscience Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ascletis Bioscience Co Ltd filed Critical Ascletis Bioscience Co Ltd
Publication of WO2024169774A2 publication Critical patent/WO2024169774A2/fr
Publication of WO2024169774A3 publication Critical patent/WO2024169774A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne les analogues nucléosidiques et nucléotidiques représentés par la formule (I), des sels pharmaceutiquement ou physiologiquement acceptables de ceux-ci, et des isomères de ceux-ci, R1, R2, R3, R4, R5, R6, X et A étant tels que définis dans la présente demande.
PCT/CN2024/076229 2023-02-17 2024-02-06 Analogues nucléosidiques et de nucléotidiques, leurs procédés de fabrication et leurs procédés d'utilisation Ceased WO2024169774A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202310155572 2023-02-17
CN202310155572.6 2023-02-17

Publications (2)

Publication Number Publication Date
WO2024169774A2 WO2024169774A2 (fr) 2024-08-22
WO2024169774A3 true WO2024169774A3 (fr) 2024-09-19

Family

ID=90362044

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2024/076229 Ceased WO2024169774A2 (fr) 2023-02-17 2024-02-06 Analogues nucléosidiques et de nucléotidiques, leurs procédés de fabrication et leurs procédés d'utilisation

Country Status (1)

Country Link
WO (1) WO2024169774A2 (fr)

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873515A (en) * 1971-04-15 1975-03-25 Asahi Chemical Ind Process for producing 2,2{40 -anhydro-(1-{62 -D-ara-binofuranosyl)cytosine
JPS51108099A (en) * 1975-03-15 1976-09-25 Asahi Chemical Ind Anhidoro 11 * beeta dei arabinofuranoshiru no pirimijinjudotainoseizohoho
EP1541581A1 (fr) * 2002-08-22 2005-06-15 Geneticlab Co., Ltd. 4'-thionucleotide
WO2012142523A2 (fr) * 2011-04-13 2012-10-18 Gilead Sciences, Inc. Analogues de n-nucléoside de pyrimidine 1'-substitués pour un traitement antiviral
WO2014197578A1 (fr) * 2013-06-05 2014-12-11 Idenix Pharmaceuticals, Inc. 1',4'-thio nucléosides pour le traitement du virus de l'hépatite c (vhc)
WO2015072784A1 (fr) * 2013-11-14 2015-05-21 Kainos Medicine, Inc. Promédicament réciproque comportant des acides gras à chaîne courte et de la zébularine ou de la 1'-cyano-cytarabine pour un traitement de cancer
CN111548384A (zh) * 2020-03-29 2020-08-18 常州安蒂卫生物科技有限公司 用于抗新型冠状病毒治疗的被取代的n4-羟基胞苷衍生物及其前药
WO2021197589A1 (fr) * 2020-03-31 2021-10-07 BioNTech SE Traitement faisant appel à un arn non immunogène pour la vaccination d'antigènes
CN113563400A (zh) * 2021-07-26 2021-10-29 大连大学 一种4-硫-5-氟-2`,3`,5`-o-三乙酰基尿苷合成方法
WO2021225767A1 (fr) * 2020-05-05 2021-11-11 The Scripps Research Institute Méthodes et compositions pour le traitement du sars-cov 2
WO2022217153A2 (fr) * 2021-04-09 2022-10-13 Emory University Analogues de nucléosides et de nucléotides utilisés en tant qu'agents antiviraux
WO2022218274A1 (fr) * 2021-04-15 2022-10-20 中国科学院上海药物研究所 Analogue de nucléoside et son utilisation

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873515A (en) * 1971-04-15 1975-03-25 Asahi Chemical Ind Process for producing 2,2{40 -anhydro-(1-{62 -D-ara-binofuranosyl)cytosine
JPS51108099A (en) * 1975-03-15 1976-09-25 Asahi Chemical Ind Anhidoro 11 * beeta dei arabinofuranoshiru no pirimijinjudotainoseizohoho
EP1541581A1 (fr) * 2002-08-22 2005-06-15 Geneticlab Co., Ltd. 4'-thionucleotide
WO2012142523A2 (fr) * 2011-04-13 2012-10-18 Gilead Sciences, Inc. Analogues de n-nucléoside de pyrimidine 1'-substitués pour un traitement antiviral
WO2014197578A1 (fr) * 2013-06-05 2014-12-11 Idenix Pharmaceuticals, Inc. 1',4'-thio nucléosides pour le traitement du virus de l'hépatite c (vhc)
WO2015072784A1 (fr) * 2013-11-14 2015-05-21 Kainos Medicine, Inc. Promédicament réciproque comportant des acides gras à chaîne courte et de la zébularine ou de la 1'-cyano-cytarabine pour un traitement de cancer
CN111548384A (zh) * 2020-03-29 2020-08-18 常州安蒂卫生物科技有限公司 用于抗新型冠状病毒治疗的被取代的n4-羟基胞苷衍生物及其前药
WO2021197589A1 (fr) * 2020-03-31 2021-10-07 BioNTech SE Traitement faisant appel à un arn non immunogène pour la vaccination d'antigènes
WO2021225767A1 (fr) * 2020-05-05 2021-11-11 The Scripps Research Institute Méthodes et compositions pour le traitement du sars-cov 2
WO2022217153A2 (fr) * 2021-04-09 2022-10-13 Emory University Analogues de nucléosides et de nucléotides utilisés en tant qu'agents antiviraux
WO2022217155A2 (fr) * 2021-04-09 2022-10-13 Emory University Thionucléosides en guise d'agents antiviraux
WO2022218274A1 (fr) * 2021-04-15 2022-10-20 中国科学院上海药物研究所 Analogue de nucléoside et son utilisation
US20240166680A1 (en) * 2021-04-15 2024-05-23 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Nucleoside analog and use thereof
CN113563400A (zh) * 2021-07-26 2021-10-29 大连大学 一种4-硫-5-氟-2`,3`,5`-o-三乙酰基尿苷合成方法

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
COLIN B. REESE: "The synthesis of oligoribonucleotides. Part XI. Preparation of ribonucleoside 2'-acetal 3'-esters by selective deacylation", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, no. 10, 1 January 1975 (1975-01-01), Cambridge, UK, pages 934 - 942, XP093167634, ISSN: 0300-922X, DOI: 10.1039/P19750000934 *
DAVID LIPKIN: "Diastereosiomeric benzylidenenucleosides", TETRAHEDRON LETTERS, vol. 1, no. 21, 1 January 1959 (1959-01-01), Amsterdam , NL, pages 18 - 21, XP093167802, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(01)99486-9 *
GADAKH BHARAT ET AL: "Synthesis and structural insights into the binding mode of the albomycin [delta]1 core and its analogues in complex with their target aminoacyl-tRNA synthetase", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 28, no. 17, 13 July 2020 (2020-07-13), XP086241847, ISSN: 0968-0896, [retrieved on 20200713], DOI: 10.1016/J.BMC.2020.115645 *
GUINAN MIEKE ET AL: "Chemical synthesis of 4'-thio and 4'-sulfinyl pyrimidine nucleoside analogues", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 20, no. 7, 16 February 2022 (2022-02-16), pages 1401 - 1406, XP093190708, ISSN: 1477-0520, DOI: 10.1039/D1OB02097H *
H.P.M. FROMAGEOT: "The synthesis of oligoribonucleotides-III", TETRAHEDRON, vol. 23, no. 5, 1 May 1967 (1967-05-01), AMSTERDAM, NL, pages 2315 - 2331, XP093167629, ISSN: 0040-4020, DOI: 10.1016/0040-4020(67)80068-1 *
HAEBERLI P ET AL: "SYNTHESIS OF 4'-THIORIBONUCLEOSIDES AND THERMODYNAMIC STABILITY AND CRYSTAL STRUCTURE OF RNA OLIGOMERS WITH INCORPORATED 4'-THIOCYTOSINE", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, GB, vol. 33, no. 13, 1 August 2005 (2005-08-01), pages 3965 - 3975, XP003014140, ISSN: 0305-1048, DOI: 10.1093/NAR/GKI704 *
J. ZEMLICKA: "Synthesis of 2'(3')-O-aminoacyl derivatives of ribonucleosides and ribonucleoside-5'-phosphates via orthoester intermediates. The preparation of 2'(3')-O-glycyl derivatives of uridine, adenosine and adenosine-5'-phosphate", TETRAHEDRON LETTERS, vol. 6, no. 34, 1 January 1965 (1965-01-01), Amsterdam , NL, pages 3057 - 3063, XP093167625, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(01)89258-3 *
LETTIERI STEFANIA ET AL: "A novel Hamilton receptor monomer for the stoichiometric molecular imprinting of barbiturates", REACTIVE AND FUNCTIONAL POLYMERS, vol. 167, 1 October 2021 (2021-10-01), AMSTERDAM, NL, pages 105031, XP093190476, ISSN: 1381-5148, DOI: 10.1016/j.reactfunctpolym.2021.105031 *
MELONCELLI P J ET AL: "Glycosyl iodides. History and recent advances", CARBOHYDRATE RESEARCH, PERGAMON, GB, vol. 344, no. 9, 12 June 2009 (2009-06-12), pages 1110 - 1122, XP026138943, ISSN: 0008-6215, [retrieved on 20090309], DOI: 10.1016/J.CARRES.2009.02.032 *
RICHARD HUANG: "Antiviral activity of some natural and synthetic sugar analogues", FEBS LETTERS, vol. 291, no. 2, 21 October 1991 (1991-10-21), NL, pages 199 - 202, XP093167730, ISSN: 0014-5793, Retrieved from the Internet <URL:https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793(91)81283-E> DOI: 10.1016/0014-5793(91)81283-E *
URBAS BRANKO ET AL: "Synthesis of Purine and Pyrimidine Nucleosides of Thiopentoses 1", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 31, no. 3, 1 March 1966 (1966-03-01), United States, pages 813 - 816, XP093190493, ISSN: 0022-3263, DOI: 10.1021/jo01341a039 *
WOOD JAMES M. ET AL: "Chemical Synthesis of the Antiviral Nucleotide Analogue ddhCTP", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 86, no. 13, 2 July 2021 (2021-07-02), pages 8843 - 8850, XP055944798, ISSN: 0022-3263, DOI: 10.1021/acs.joc.1c00761 *

Also Published As

Publication number Publication date
WO2024169774A2 (fr) 2024-08-22

Similar Documents

Publication Publication Date Title
SE0202462D0 (sv) Novel use
WO2007022073A3 (fr) Nouveaux dérivés de 2’-c-méthyl- et de 4’-c-méthyl-nucléosides
NO20063231L (no) Pyrido[2,3-D]pyrimidin-2,4-diaminer som PDE 2 inhibitorer
WO2004058679A3 (fr) Ligands d&#39;adenine nucleotide translocase (ant) et compositions et methodes associees
WO2003072757A3 (fr) Mimetiques nucleotidiques et leurs promedicaments
WO2006067165A3 (fr) Medicaments pour le traitement ou la prevention de maladies fibrotiques
NO20060111L (no) Spesifikke glukokortikosteroid forbindelser med anti- inflammatorisk aktivitetet
NO20035210L (no) 2-anilino-pyrimidinderivater som cyklinavhengige kinaseinhibitorer
ZA200501098B (en) Novel use of benzothiazole derivatives
WO2005094329A3 (fr) Composes, compositions, procedes de fabrication, et procedes d&#39;utilisation destines inhiber le facteur d&#39;inhibition de la migration des macrophages
WO2010132757A3 (fr) Analogues d&#39;aminoglycoside antibactériens
NO20040881L (no) Orale antidiabetes midler.
WO2023141432A3 (fr) Inhibiteurs d&#39;apol1 et méthodes d&#39;utilisation
EP4403174A3 (fr) Derives de pyrrolo[1,2-b!pyridazine
CA2469592A1 (fr) Inhibiteurs de l&#39;integrase du vih
WO2023246870A9 (fr) Préparation, application et utilisation d&#39;un composé indole
CA2364251A1 (fr) Inhibition synergique de replication virale par des hydrocarbures et analogues nucleosidiques a chaine longue
WO2006033709A3 (fr) Nouveaux derives de nucleosides
WO2024169774A3 (fr) Analogues nucléosidiques et de nucléotidiques, leurs procédés de fabrication et leurs procédés d&#39;utilisation
MX2025013601A (es) Inhibidor selectivo de hdac1/2 y uso de este
WO2009137130A3 (fr) Analogues de fluoroquinolones antibactériens
WO2024249254A3 (fr) Procédés d&#39;utilisation d&#39;inhibiteurs d&#39;apol1
WO2004058683A3 (fr) Ligands d&#39;adenine nucleotide translocase (ant) et compositions et methodes associees
CA2470066A1 (fr) Derives d&#39;acide 3-phenyl-2-arylalkylthiopropionique utilises comme agonistes selectifs de ppar-alpha
MXPA04004371A (es) Agente antipruritico.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 24709636

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE