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WO2024158989A1 - Cathéter de guidage - Google Patents

Cathéter de guidage Download PDF

Info

Publication number
WO2024158989A1
WO2024158989A1 PCT/US2024/012907 US2024012907W WO2024158989A1 WO 2024158989 A1 WO2024158989 A1 WO 2024158989A1 US 2024012907 W US2024012907 W US 2024012907W WO 2024158989 A1 WO2024158989 A1 WO 2024158989A1
Authority
WO
WIPO (PCT)
Prior art keywords
channel
guide catheter
guide
catheter hub
catheter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2024/012907
Other languages
English (en)
Inventor
Himanshu Singh
Rushi Vrajmohan PARIKH
Yohan CHACKO
Andrew Fisher
Bruce YOUNGBERG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stallion Catheter Inc
Original Assignee
Stallion Catheter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stallion Catheter Inc filed Critical Stallion Catheter Inc
Publication of WO2024158989A1 publication Critical patent/WO2024158989A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0097—Catheters; Hollow probes characterised by the hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0102—Insertion or introduction using an inner stiffening member, e.g. stylet or push-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/06—Body-piercing guide needles or the like
    • A61M25/0662—Guide tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M2025/0175—Introducing, guiding, advancing, emplacing or holding catheters having telescopic features, interengaging nestable members movable in relations to one another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/06—Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof

Definitions

  • the present invention relates generally to a guide catheter for cardiovascular procedures.
  • Embodiments described herein relate to guide catheter hubs and catheter systems.
  • the catheter system can include a guide catheter and a telescoping guide extension catheter.
  • the guide extension catheter may reduce the availability of space within the system which may limit or prevent certain additional equipment from passing through the system.
  • embodiments of the catheter system can significantly improve the use of the system by addressing these and other issues.
  • the techniques described herein relate to a guide catheter hub.
  • the guide catheter hub can include a tubular body including a proximal end, a distal end, an interior surface, and an exterior surface; a sidewall extending from the interior surface of the tubular body on a proximal portion of the tubular body; a first channel extending from a first portion of the sidewall to the distal end of the tubular body; and a second channel extending from a second portion of the sidewall to the first channel.
  • the second channel can be configured to receive a push wire.
  • a proximal end of the first channel can be unobstructed when the push wire is inserted in the second channel.
  • an internal diameter of the second channel and a width of the push wire are substantially the same.
  • the push wire can extend from the proximal end of the tubular body to the distal end of the tubular body and through the first and second channels when the push wire is inserted in the second channel.
  • An internal diameter of the first channel can be larger than an internal diameter of the second channel.
  • the sidewall extends substantially perpendicular to the first channel.
  • the techniques described herein relate to a guide catheter hub, wherein the second channel intersects the first channel at an acute angle.
  • the proximal end of the tubular body can be configured to connect to a hemostatic valve.
  • the distal end of the tubular body can be configured to connect to a guide catheter.
  • a distal portion of the tubular body can taper in a distal direction.
  • the tubular body can include one or more tabs extending outwardly from the exterior surface.
  • the guide catheter hub can include a cavity on the proximal end of the tubular body, wherein the cavity is in fluid communication with the first and second channels.
  • a diameter of the cavity can be larger than an internal diameter of the first channel and an internal diameter of the second channel.
  • a catheter system can include guide catheter hub.
  • the guide catheter hub can include a body including a proximal end, a distal end, an interior surface, and an exterior surface; a sidewall extending from the interior surface of the body on a proximal portion of the body; a first channel extending from a first portion of the sidewall to the distal end of the body; and a second channel extending from a second portion of the sidewall to the first channel; a guide catheter shaft including a distal portion including a distal end, a proximal portion including a proximal end, and a middle portion extending therebetween, wherein the distal portion is configured to be positioned within an artery and the proximal end is connected to the distal end of the guide catheter hub; and a guide extension catheter including a distal portion including a distal end, a proximal portion including a proximal end, a middle portion extending therebetween, and a push wire on the prox
  • a proximal end of the first channel can be unobstructed when the push wire extends through the second channel.
  • an internal diameter of the second channel and a width of the push wire can be substantially the same.
  • An internal diameter of the first channel can be larger than an internal diameter of the second channel.
  • the sidewall of the guide catheter hub can extend substantially perpendicular to the first channel.
  • the second channel of the guide catheter hub intersects the first channel at an acute angle.
  • the proximal end of the body can be configured to connect to a hemostatic valve.
  • a distal portion of the body can taper in a distal direction.
  • the body can include one or more tabs extending outwardly from the exterior surface.
  • the guide catheter hub includes a cavity on the proximal end of the body, wherein the cavity is in fluid communication with the first and second channels. In some cases, a diameter of the cavity is larger than an internal diameter of the first channel and an internal diameter of the second channel.
  • FIG. 1A illustrates an embodiment of a guide catheter hub.
  • FIG IB illustrates a cross-section view of the guide catheter hub shown in
  • FIG. 1A is a diagrammatic representation of FIG. 1A.
  • FIG. 2 illustrates an embodiment of a catheter system including a guide catheter hub and a guide catheter shaft.
  • Embodiments described herein relate to a guide catheter hub and a catheter system.
  • the catheter system can include a guide catheter shaft, a telescoping guide extension catheter, and a guide catheter hub.
  • the devices disclosed herein can be used to significantly improve use of the guide catheter and guide extension catheter without adding significant manufacturing and/or assembly cost.
  • Embodiments of guide catheter devices and methods can be particularly impactful on accessing vasculature.
  • any technology described herein i.e. catheter system
  • any vascular procedures including but not limited to neurovascular, renovascular, and other peripheral vascular procedures.
  • a guide catheter can be a round and hollow plastic tube.
  • the plastic can be braided with metal for added stability.
  • the hollow tube can be inserted percutaneously into arteries, for example, through the wrist or groin, and can be navigated to an opening of a coronary artery where the distal end of the guide catheter and/or a guide extension catheter can sit.
  • the guide catheter and/or guide extension catheter can be very small in diameter, ranging from about 0.05 in. to about 0.10 inches in diameter.
  • the guide catheter can be used as a conduit or protective placeholder to facilitate delivery of other materials into the coronary artery.
  • a thin metal wire or coronary wire
  • a thin metal wire can be placed in the middle of the guide catheter over which one or more stents or balloons can be passed within the inner diameter of the guide catheter.
  • Guide extension catheters can be inserted into a guide catheter.
  • the guide extension catheter can include a tubular body and a wire secured to a proximal portion of the tubular body.
  • the distal section of the guide extension catheter can be pushed beyond the distal end of the guide catheter into tortuous and/or heavily calcified arteries to extend the support offered by the guide catheter by providing additional support for delivery of balloons/stents.
  • the use of a guide extension catheter device within the guide catheter can create additional complications and difficulties throughout the medical procedure.
  • the guide extension catheter may reduce the availability of space within the guide catheter which may limit or prevent certain additional equipment from passing through the system.
  • a guide catheter hub can be secured to a proximal end of a guide catheter.
  • the guide extension catheter can have a distal end and a proximal end.
  • the guide extension catheter can be arranged to extend from the distal end of the guide catheter into the necessary vasculature, for example, the arteries.
  • the proximal end of the guide extension catheter can be in communication with the proximal end of the guide catheter and and/or a wire that can be used to move or actuate the guide extension catheter.
  • the tubular portion of the guide extension catheter can be advanced or retracted along the guide catheter by pushing or pulling the wire.
  • the guide catheter hubs described herein can include two or more channels allowing the catheter hubs to receive two or more wires, which can be advantageous in procedures where more than one catheter and/or wires are in use.
  • the use of two more channels can beneficially allow at least one of the channels to be unobstructed when only one wire is used.
  • the two or more channels can also allow for quick and efficient manipulation and/or identification of wires/instruments extending through the guide catheter hub. By partially separating two or more wires extending through a proximal portion of the guide catheter hub, the risk of wire kinking can be reduced.
  • FIGS. 1A and IB show an example of a guide catheter hub.
  • the guide catheter hub 102 can include a tubular body 110 including a proximal end 112 , a distal end 114, and a sidewall 116 shown in Figures 1 A- IB.
  • the sidewall 116 can extend radially inward from an interior portion on the proximal end 112 of the guide catheter hub 102.
  • a distal portion of the tubular body 110 can taper in a distal direction, as shown in FIG. IB.
  • the tubular body 110 can include a first channel 120 and a second channel 130.
  • the first channel 120 can extend from a first portion 116a of the sidewall 116 to the distal end 114 of the guide catheter hub 102.
  • the second channel 130 can extend from a second portion 116b of the sidewall 116 to the first channel 120.
  • the second channel 130 can intersect the first channel at an intersection area 131.
  • the intersection area 131 can include an opening and be positioned along any point across the length of the first channel 120.
  • the guide catheter hub 102 can also include one or more fins 118 extending radially outward from an exterior surface of the guide catheter hub 102, and a cavity 119 on the proximal end 112.
  • the sidewall 116 can form a distal end of the cavity 119. In some cases, the sidewall 116 extends perpendicular or substantially perpendicular to the first channel 120.
  • the cavity 119 can include a tapered luer fitting which can beneficially be used to connect the guide catheter hub 102 to other tools, valves, tubing and/or equipment.
  • the tapered luer fitting can also beneficially provide a hermetic seal between the guide catheter hub 102 and the tools, valves, tubing and/or equipment.
  • the second channel 130 can intersect the first channel at an angle.
  • the first and second channels 120, 130 can form an angle A.
  • the angle A can include an acute angle.
  • the angle A can include an angle from about 5° to about 40°, from about 10° to about 35°, from about 15° to about 30°, and/or from about 20° to about 25°.
  • the angle A can beneficially facilitate mobility of a guide extension catheter wire along the second channel 130, and/or prevent kinking.
  • a guide extension catheter wire 160 can extend through the guide catheter hub 102.
  • the guide extension catheter wire 160 can extend through the first and second channels 120, 130. As shown in FIG. IB, the guide extension catheter wire 160 can extend through an entire length of the second channel 130, continue extending through the first channel 120, and exit the tubular body 1 10 via an opening 114a on the distal end 114. A proximal end 120a of the first channel 120 can beneficially remain unobstructed when the guide extension catheter wire 160 extends through the second channel 130.
  • the guide extension catheter wire 160 includes a noncircular shaped proximal portion and a circular shaped proximal portion.
  • the guide extension catheter wire 160 can include a crescent shaped cross-section with a radius of curvature that matches or closely matches a radius of curvature of an inner surface of a guide catheter shaft. This crescent shaped cross-section can allow for space within the guide catheter shaft to remain unobstructed.
  • the second channel 130 can be shaped to accommodate a guide extension catheter wire 160 with any cross-sectional shape.
  • the guide extension catheter wire 160 can be advanced through the first and second channels 120, 130 to move the guide extension catheter wire 160 and a corresponding guide extension catheter (not shown) in a proximal to distal direction.
  • the guide extension catheter wire 160 can be advanced from the proximal end 112 of the guide catheter hub 102 to the distal end 114 of the guide catheter hub 102. Advancing the guide extension catheter wire 160 in a proximal to distal direction can cause the corresponding guide extension catheter (or a distal portion of the guide extension catheter) to extend beyond a distal end of a guide catheter (not shown).
  • the guide extension catheter wire 160 can be retracted so the guide extension catheter wire 160 moves in a distal to proximal direction from the distal end 114 of the guide catheter hub 102 to the proximal end 112 of the guide catheter hub 102. Retracting the guide extension catheter wire 160 in a distal to proximal direction can cause the corresponding guide extension catheter to retract within a distal end of the guide catheter.
  • the guide extension catheter wire 160 and the corresponding guide extension catheter can extend within the guide catheter.
  • the guide catheter can be connected to the distal end 114 of the tubular body 110.
  • the guide extension catheter can be pre-embedded within the guide catheter described in PCT International Application No.
  • the guide extension catheter wire 160 can be preloaded inside the guide catheter hub 102, as shown and described herein. This can beneficially allow the guide extension catheter wire 160 to be advanced or retracted to extend or retract the corresponding guide extension catheter though the guide catheter.
  • an internal diameter of the second channel 130 and a width of the guide extension catheter wire 160 can be identical or substantially the same. This can beneficially prevent twisting or tangling of the guide extension catheter wire 160 when the guide extension catheter wire 160 is pushed through the second channel 130.
  • an internal diameter of the first channel 120 is larger than the internal diameter of the second channel 130.
  • a diameter of the cavity 119 can be larger than the internal diameters of the first and second channels 120, 130.
  • the guide extension catheter wire 160 can have different properties or characteristics throughout the length of the wire.
  • the guide extension catheter wire 160 can have different widths at the proximal end than the width of a more distal part of the guide extension catheter wire 160 that is passed through the guide catheter.
  • the guide extension catheter wire 160 can be less flexible at the more distal portions that are extended through the guide catheter to prevent the guide extension catheter wire 160 from twisting, tangling, bending, or otherwise preventing movement of the guide extension catheter wire 160 within the guide catheter.
  • the proximal end of the guide extension catheter wire 160 can be a different shape than the guide extension catheter wire 160 at the more distal end.
  • the guide extension catheter wire 160 at the proximal end is the same shape and material as the guide extension catheter wire 160 at the more distal ends of the device.
  • the guide extension catheter wire 160 can include a stopper (not shown).
  • the stopper can beneficially prevent the guide extension catheter wire 160 from retracting beyond a point along the length of the guide catheter hub 102.
  • the stopper can include an edge extending radially outward from the guide extension catheter wire 160.
  • a diameter of the edge can be larger than a diameter of the first and/or second channels 120, 130 thus preventing retraction of the guide extension catheter wire 160 when the edge reaches the distal ends of the first and/or second channels when the guide extension catheter wire 160 is being retracted (e.g., the wire is being advanced from a distal end 114 to a proximal end 112 of the guide catheter hub 102).
  • the guide catheter can include a constant outer diameter and a variable inner diameter
  • the guide extension catheter can include a constant inner diameter and a variable outer diameter.
  • the stopper can beneficially prevent the guide extension catheter from retracting beyond a point along the length of the guide catheter where an outer diameter of the guide extension catheter is the same as or larger than an internal diameter of the guide catheter. Further details of guide catheters and guide extension catheters including variable inner and/out outer diameters are described in relation to FIGS. 3OA-3OF of International Application Number PCT/US2022/074029, which was filed on July 21, 2022, and which is incorporated herein by reference in its entirety.
  • an inner diameter of the second channel 130 can be smaller than an inner diameter of the first channel 120.
  • the inner diameters of the first channel 120 and/or the second channel 130 can be big enough to allow some medical devices, instruments, and/or portions thereof to extend through the channels but prevent other medical devices, instruments, and/or portions thereof from extending through the channels.
  • the inner diameter of the second channel 130 may allow a wire of the guide extension catheter to extend through the second channel 130 but prevent the tubular- body of the extension catheter from extending through the second channel 130.
  • the inner diameter of the second channel 130 can allow both the wire of the guide extension catheter and the tubular body of the guide extension catheter to extend through the second channel 130. This can beneficially allow for the complete insertion and removal of the guide extension catheter through the second channel 130 of the guide catheter hub 102 if needed.
  • the inner diameter of the first channel 120 may allow both the wire and the tubular body of a guide extension catheter to extend through the first channel 130. This can beneficially allow for the complete insertion and removal of the guide extension catheter from a guide catheter and/or the guide catheter hub 102 if needed.
  • a guide catheter hub can be integrated with other components to form a catheter system.
  • the catheter system 200 can include a guide catheter hub 202, which can be similar or identical to the guide catheter hub 102 which is described in relation to FIGS. 1A and IB, a guide catheter shaft 240, and a hemostatic valve 250.
  • the guide catheter shaft 240 can be connected to a distal end 202b of the guide catheter hub 202.
  • the hemostatic valve 250 can be connected to a proximal end 202a of the guide catheter hub 202.
  • a guide extension catheter wire can extend through a second channel of the guide catheter hub 202.
  • the guide extension catheter can exit the second channel and extend through a first channel of the guide catheter hub 202.
  • the guide extension catheter wire can extend inside the guide catheter shaft 240.
  • the guide extension catheter wire and a corresponding guide extension catheter can extend an entire length of the guide catheter shaft 240. In some cases, the guide extension catheter extends beyond a distal end of the guide catheter shaft 240.
  • any of the guide catheters hubs disclosed herein can be integrated into any of the catheter systems disclosed in International Application Number PCT/US2022/074029, which was filed on July 21, 2022, and which is incorporated herein by reference in its entirety.
  • any value of a threshold, limit, duration, etc. provided herein is not intended to be absolute and, thereby, can be approximate.
  • any threshold, limit, duration, etc. provided herein can be fixed or varied either automatically or by a user.
  • relative terminology such as exceeds, greater than, less than, etc. in relation to a reference value is intended to also encompass being equal to the reference value. For example, exceeding a reference value that is positive can encompass being equal to or greater than the reference value.
  • relative terminology such as exceeds, greater than, less than, etc. in relation to a reference value is intended to also encompass an inverse of the disclosed relationship, such as below, less than, greater than, etc. in relations to the reference value.
  • the various components illustrated in the figures or described herein may be implemented as software and/or firmware on a processor, controller, ASIC, FPGA, and/or dedicated hardware.
  • the software or firmware can include instructions stored in a non-transitory computer-readable memory.
  • the instructions can be executed by a processor, controller, ASIC, FPGA, or dedicated hardware.
  • Hardware components such as controllers, processors, ASICs, FPGAs, and the like, can include logic circuitry.
  • Conditional language used herein such as, among others, “can,” “could”, “might,” “may,” “e.g.,” and the like, unless specifically stated otherwise, or otherwise understood within the context as used, is generally intended to convey that certain embodiments include, while other embodiments do not include, certain features, elements and/or states. Thus, such conditional language is not generally intended to imply that features, elements and/or states are in any way required for one or more embodiments or that one or more embodiments necessarily include logic for deciding, with or without author input or prompting, whether these features, elements and/or states are included or are to be performed in any particular embodiment.
  • the terms “generally parallel” and “substantially parallel” refer to a value, amount, or characteristic that departs from exactly parallel by less than or equal to 15 degrees, 10 degrees, 5 degrees, 3 degrees, 1 degree, or 0.1 degree.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Un raccord de cathéter de guidage peut comprendre un corps tubulaire comprenant une extrémité proximale, une extrémité distale, une surface intérieure et une surface extérieure. Le raccord de cathéter de guidage peut comprendre une paroi latérale s'étendant à partir de la surface intérieure du corps tubulaire sur une partie proximale du corps tubulaire. Le raccord de cathéter de guidage peut comprendre un premier canal s'étendant d'une première partie de la paroi latérale à l'extrémité distale du corps tubulaire, et un second canal s'étendant d'une seconde partie de la paroi latérale au premier canal.
PCT/US2024/012907 2023-01-25 2024-01-25 Cathéter de guidage Ceased WO2024158989A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363481596P 2023-01-25 2023-01-25
US63/481,596 2023-01-25

Publications (1)

Publication Number Publication Date
WO2024158989A1 true WO2024158989A1 (fr) 2024-08-02

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/012907 Ceased WO2024158989A1 (fr) 2023-01-25 2024-01-25 Cathéter de guidage

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WO (1) WO2024158989A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018323A2 (fr) * 1998-09-30 2000-04-06 Lumend, Inc. Procedes et dispositif permettant de traverser des occlusions vasculaires
US20090105597A1 (en) * 2006-10-12 2009-04-23 Innoscion, Llc Image guided catheter having remotely controlled surfaces-mounted and internal ultrasound transducers
US20190351183A1 (en) * 2017-03-23 2019-11-21 Terumo Kabushiki Kaisha Catheter assembly
CN111658089A (zh) * 2020-06-30 2020-09-15 湖南省妇幼保健院 一种腰硬联合麻醉穿刺针
CN215780826U (zh) * 2020-06-29 2022-02-11 巴德阿克塞斯系统股份有限公司 两件式导管

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018323A2 (fr) * 1998-09-30 2000-04-06 Lumend, Inc. Procedes et dispositif permettant de traverser des occlusions vasculaires
US20090105597A1 (en) * 2006-10-12 2009-04-23 Innoscion, Llc Image guided catheter having remotely controlled surfaces-mounted and internal ultrasound transducers
US20190351183A1 (en) * 2017-03-23 2019-11-21 Terumo Kabushiki Kaisha Catheter assembly
CN215780826U (zh) * 2020-06-29 2022-02-11 巴德阿克塞斯系统股份有限公司 两件式导管
CN111658089A (zh) * 2020-06-30 2020-09-15 湖南省妇幼保健院 一种腰硬联合麻醉穿刺针

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