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WO2024158442A1 - Composition de soins personnels à matrice glycoprotéique et procédés associés - Google Patents

Composition de soins personnels à matrice glycoprotéique et procédés associés Download PDF

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Publication number
WO2024158442A1
WO2024158442A1 PCT/US2023/073764 US2023073764W WO2024158442A1 WO 2024158442 A1 WO2024158442 A1 WO 2024158442A1 US 2023073764 W US2023073764 W US 2023073764W WO 2024158442 A1 WO2024158442 A1 WO 2024158442A1
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Prior art keywords
vitamin
personal care
care composition
glycoprotein
agents
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PCT/US2023/073764
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English (en)
Inventor
Jean-Marie Botto
Neil ASTLES
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ISP Investments LLC
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ISP Investments LLC
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/064—Saccharomycetales, e.g. baker's yeast

Definitions

  • the presently disclosed process(es), procedure(s), method(s), product(s), result(s), and/or concept(s) (collectively referred to hereinafter as the “present disclosure or invention”) relates generally to glycoprotein matrix personal care compositions, methods related thereto, and use of the composition thereof.
  • the present invention relates to a glycoprotein matrix personal care composition, methods related thereto, and use of the composition thereof.
  • Glycosylated proteins are present in the extracellular matrices and cellular surfaces of many cells.
  • Glycoproteins are organic compounds composed of both a protein and a carbohydrate joined together by a covalent linkage.
  • the oligosaccharide moieties of the glycoprotein are implicated in a wide range of cell-cell and cell-matrix recognition events.
  • the addition of the carbohydrates on the protein involves a complex series of reactions that are catalyzed by membrane-bound glycosyltransferases and glycosidases. The types and amounts of sugars that are attached to a given protein depend on the cell type in which the glycoprotein is expressed.
  • U.S. Pat.t no. 11,219,585 describes a topical cosmetic or dermatological preparation, comprising a glycoprotein and other ingredients.
  • Vitamin C which whitens & revitalize teeth to provide maximum stain removal. It whitens yellowish teeth or stained teeth due to use of tobacco or hot beverages. It is effective for all type of gums & teeth problems. Vitamin C can help heal blemishes, reduce hyperpigmentation, and give skin an out-of-this-world glow. Vitamin E may help support a healthy scalp and hair as it has natural antioxidant effects.
  • Biotin helps improve skin's hydration, smoothness, and appearance. In addition, biotin can strengthen fingernails and make them grow faster. Biotin is a versatile addition to personal care.
  • the primary aspect of the present application is to provide a personal care composition, comprising: (a) 0.1 to 10 wt.% of one or more glycoprotein matrix; (b) 0.01 to 90 wt.% of one or more cosmetically acceptable ingredient; and wherein, the glycoprotein matrix is bound to one or more biologically active ingredient.
  • Yet another aspect of the present application discloses a method of preparing a glycoprotein-matrix of personal care composition comprising binding a glycoprotein matrix to at least one active ingredient Docket No.: 4305PCT
  • Another aspect of the present application provides a personal care composition comprising a vitamin bound by a glycoprotein matrix, wherein said composition is obtained by a process comprising i) adding a vitamin to a water based microorganism solution containing carbohydrates and Saccharomyces cerevisiae, and fermenting to obtain a first fermented solution, ii) adding a proteolytic enzyme to the first fermented solution obtained from part (i), iii) adding Lactobacillus acidophilus and Bacterium bifidum to the first fermented solution containing the proteolytic enzyme of part (ii) and fermenting to obtain a final fermented solution; and iv) drying a final fermented solution to obtain vitamin bound by a glycoprotein matrix.
  • the words “comprising” (and any form of comprising, such as “comprise” and “comprises”), “having” (and any form of having, such as “have” and “has”), “including” (and any form of including, such as “includes” and “include”) or “containing” (and any form of containing, such as “contains” and “contain”) are inclusive or open-ended and do not exclude additional, unrecited elements or method steps.
  • the term “each independently selected from the group consisting of” means when a group appears more than once in a structure, that group may be selected independently each time it appears.
  • the term “host” refers to body, skin or keratin substrate of a mammal.
  • the term “bound to”, “bound by” and binding refers to binding of biologically active ingredient to glycoprotein matrix.
  • the term “keratin substrate” as used herein includes skin, nails and “keratin fibers”, and wherein the "keratin fibers” means hair on head, eyelashes, eyebrows and other mammalian bodily hair.
  • compositions intended for use on or in the human body such as skin, sun, hair, oral, cosmetic, and preservative compositions, including those to alter the color and appearance of the skin and hair
  • One of the embodiments of the present application is to provide a personal care composition, comprising: (a) 0.1 to 10 wt.% of one or more glycoprotein matrix; (b) 0.01 to 90 wt.% of one or more cosmetically acceptable ingredient; and wherein, the glycoprotein matrix is bound to one or more biologically active ingredient.
  • the glycoprotein matrix can be produced by microorganisms, such as yeast or bacteria. Examples of microorganisms including but not limited to Saccharomyces cerevisiae and bacteria within the genus Lactobacillus.
  • the composition of the invention can also include stabilizers or additives to improve its properties.
  • the composition of the invention also includes a bioflavonoid, such as hesperidin, as a stabilizer.
  • the method is also provided for preparing a glycoprotein matrix containing composition.
  • the method includes binding a glycoprotein matrix to at least one biologically active ingredient.
  • the glycoprotein matrix is formed by glycoprotein producing microorganisms.
  • the binding includes contacting the active ingredient with a glycoprotein producing microorganism under conditions such that the microorganism will produce glycoprotein.
  • the glycoprotein containing composition of the invention demonstrates improved properties as compared to commercially available active ingredients not bound to glycoprotein matrix.
  • a method is also provided for increasing the bioactivity of an active ingredient.
  • a separate method is similarly provided for increasing the stability of an active ingredient.
  • the method is for delivering a biologically active ingredient to a host.
  • the method includes binding the active ingredient with a glycoprotein matrix to form a glycoprotein matrix containing composition and delivering the composition to the host.
  • a composition is provided which includes a glycoprotein matrix and a biologically active ingredient.
  • the composition of the invention provides improved stability and bioactivity characteristics of the active ingredient.
  • a glycoprotein matrix is bound to at least one biologically active ingredient.
  • glycoprotein matrix and active ingredient can be associated with each other physically and/or chemically, such as by chemical reaction, and/or secondary chemical bonding, e.g., Van der Waals forces, etc. It is believed that glycopro-tein matrix is bound to the active ingredient by weak covalent bonds.
  • biologically active means any material that affects the life processes of an organism, example a mammal.
  • the biologically active ingredient can include a drug or pharmaceutical, vitamin, mineral, chemical compound, etc.
  • suitable chemical compounds include CoQ10, and L-Carnitine base.
  • suitable minerals include selenium, chromium, zinc, iron and other standard minerals used for the cosmetic purpose.
  • the composition can contain essentially any percentage of biologically active ingredient as desired.
  • the percentage of active ingredient can vary between 0.01 and 99 wt% by total weight of glycoprotein matrix.
  • the glycoprotein matrix is the glycoprotein to which the active ingredient is bound.
  • Glycoprotein is a composite material made of a carbohydrate group and a simple protein.
  • Glycoprotein matrix is a molecular network comprised of a plurality of glycoprotein molecules bound together.
  • the carbohydrate in the glycoprotein can be any suitable carbohydrate, such as a monosaccharide, disaccharide, oligosaccharide, or polysaccharide.
  • the protein of the glycoprotein can any suitable polypeptide.
  • the ratio of carbohydrate to protein Docket No.: 4305PCT in the glycoprotein matrix can vary, for example, from 99:1 to 1:99 by weight. A ratio of approximately 1:1 is preferred.
  • the ratio of glycoprotein matrix to active ingredient can also vary. It is preferred that the ratio of glycoprotein matrix to active ingredient will be such that all or nearly all of the active ingredient in the composition is bound by glycoprotein matrix. To ensure that essentially all of the active ingredient is bound, higher ratios of glycoprotein matrix to active ingredient can be used.
  • the invention also contemplates a composition where there may be insufficient glycoprotein to bind all of the active ingredient. In such cases, the ratio of glycoprotein matrix to active ingredient can be less.
  • the source of the glycoprotein matrix is a microorganism and, therefore, a preferred composition of the invention will include microorganisms. At the end of the manufacturing process of the composition, these microorganisms are usually inactive.
  • the glycoprotein matrix can be bound to the active ingredient by allowing the microorganism to ferment, in the presence of the active ingredient. As used herein, fermentation is the process by which microorganisms metabolize raw materials or microorganism solution components, such as amino acids and carbohydrate, to produce glycoprotein.
  • the microorganisms produce glycoprotein both intracellularly and extracellularly
  • the intracellular glycoprotein will mainly be located in the cytoplasm of the microorganism or become part of the microorganism's physical structure.
  • the glycoprotein from the microorganism that forms the glycoprotein matrix is mainly extracellular and, therefore, is available to be bound to the active ingredient.
  • Intracellular glycoprotein can also be made accessible for binding to active ingredient by rupture of the microorganisms after glycoprotein production.
  • Microorganisms that produce a glycoprotein matrix include, but are not limited to, yeast and some bacteria.
  • a preferred yeast is Saccharomyces cerevisiae.
  • Bacteria that produce glycoprotein include bacteria within the genus Lactobacillus.
  • such bacteria include, but are not limited to, Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus caucasicus, and Bacterium bifidum.
  • Preferred bacteria include Lactobacillus acidophilus, and Bacterium bifidum. Docket No.: 4305PCT [0046]
  • a method of preparing a glycoprotein matrix containing composition is also provided. The method includes binding a glycoprotein matrix to at least one biologically active ingredient.
  • the binding of the glycoprotein matrix to the active ingredient includes contacting the active ingredient to a glycoprotein producing microorganism under conditions in which the microorgan-ism produces glycoprotein.
  • the microorganisms require a medium in which to ferment and produce glycoprotein. Such media are known to those skilled in the art, and are usually liquid. Water is preferred.
  • the microorganism solution should contain enough growth medium so as to allow for efficient growth of the microorganisms, as is known in the art.
  • a microorganism solution is formed.
  • Microorganism solution is prepared in which the microorganisms will produce glycoprotein.
  • the microorganisms are added to an appropriate medium that will allow microorganism growth, such as H 2 0.
  • the number of colony forming units of microorganism added to the medium will vary based upon the type of microorganism used.
  • any suitable microorganism can be used that produces a glycoprotein matrix. It is preferred that the microorganism used be acceptable for delivering to humans and mammals host.
  • Saccharomyces cerevisiae also known as baker's yeast
  • yeast can be used as the first microorganism.
  • Combinations of microorganisms can be used provided that at least one of the microorganisms produces glycoprotein.
  • the growth of one type of microorganism should not prevent the growth of the other.
  • various types of different yeast that produce glycoprotein can be used.
  • yeast and bacteria can be combined to produce glycoprotein. This combination is particularly advantageous because various types of bacteria, such as Lactobacillus acidophilus, also produce glycoprotein.
  • a sufficient amount of colony forming units should be added to the microorganism solution to bind at least some of the active ingredient. If the composition of the invention is to contain a small amount of active ingredient, fewer microorganisms will be required to bind the active ingredient with glycoprotein matrix. It is preferred that enough colony forming units be added to the microorganism solution to bind essentially all of the active ingredient with glycoprotein matrix. One skilled in the art can determine such amounts. Docket No.: 4305PCT [0051] The amount of colony forming units of the microorganism utilized can also depend upon the molecular weight and amount of the active ingredient in the composition.
  • more colony forming units are necessary to fully bind a higher molecular weight molecule that makes up a relatively high weight percentage of the final composition, such as CoQ10. Fewer colony forming units are required for a composition that includes a low molecular weight molecule or trace amount of an element as the active ingredient, such as selenium.
  • the microorganisms that produce the glycoprotein typically require nutrients to efficiently grow, multiply, and form glycoprotein by metabolizing the nutrients. The nutrients can be directly added to the microorganism solution or can be added to a nutrient media, which is then added to the microorganism solution.
  • Amino acids are one nutrient that may be necessary for efficient glycoprotein production.
  • the amino acids are metabolized by the microorganisms and ultimately become part of the polypeptide within the glycoprotein matrix.
  • the amino acids should include those that are suitable for the manufacture of glycoprotein.
  • Such amino acids include, but are not limited to, glutamine, lysine, cysteine and methionine, aspartic acid, leucine, valine, alanine, arginine, and glycine.
  • the amino acids need not be in a pure form, but can be added as part of a stable compound. Examples of amino acid compounds that can be used are L-Glutamic Acid, L-Lysine HCl, L-Cysteine HCl and DL-Methionine.
  • the amount of amino acids will vary based upon the amount, molecular weight, and percentage of active ingredient desired to be bound by glycoprotein matrix. If the active ingredient is a small molecular weight molecule or if only a trace is to be utilized as the active ingredient, it may not be necessary to add amino acids as a nutrient for the production of glycoprotein matrix by the microorganisms. For example, if trace elements, such as selenium, chromium, vanadium, molybdenum, nickel, etc. are used as the active ingredient, the microorganisms can often produce enough glycoprotein matrix to bind the active ingredient by metabolizing the carbohydrate without the need to feed the microorganisms amino acids.
  • trace elements such as selenium, chromium, vanadium, molybdenum, nickel, etc.
  • Carbohydrate is a nutrient that is added for the efficient production of glycoprotein by the microorganism. As with the amino acids, the carbohydrate can be added to a nutrient media, Docket No.: 4305PCT which is then added to the microorganism solution, or can be added directly to the microorganism solution. Carbohydrates beneficial for the production of glycoprotein are known in the art.
  • the carbohydrate can be, for example, a polysaccharide, oligosaccharide, disaccharide or monosaccharide or combinations thereof.
  • carbohydrates examples include, but are not limited to, maltose and gum acacia. Maltose is most preferred.
  • the amount of carbohydrate added to the nutrient media or microorganism solution will vary depending upon the complexity and molecular weight of the carbohydrate added to the solution. The amount of carbohydrate should be sufficient to permit the microorganisms to produce the glycoprotein matrix. The amount of carbohydrate necessary will also vary based upon the amount and percentage of active ingredient desired to be bound by glycoprotein matrix.
  • the binding of the active ingredient occurs in the microorganism solution as the glycoprotein is being produced by the microorganisms. Thus, the microorganism solution will contain the active ingredient to be bound by glycoprotein matrix.
  • the active ingredient is added before or soon after fermentation of the microorganisms begins.
  • Additional microorganisms can be added to the microorganism solution after the first microorganisms are added. It is preferred that the additional microorganisms be added after the first microorganisms have been permitted to ferment, but before the microorganism solution has been dehydrated. In a preferred embodiment, the additional microorganisms also produce glycoprotein. Additional microorganisms can also include microorganisms that improve digestibility of the components of the composition, such as the glycoprotein, or enhance the bioavailability of the active ingredient.
  • the solution should be maintained at a temperature and conditions so as to permit the growth and fermentation of both the first and additional microorganisms. Such conditions are known in the art and will usually coincide with the growth conditions for the first microorganisms, as discussed above.
  • Bacteria can be utilized as an additional microorganism. As with the first microorganisms, it its preferred that the additional microorganisms be suitable for application to mammals and, more preferably, suitable for human consumption. Examples of such bacteria are bacteria of the genus Lactobacillus, for example Lactobacillus acidophilus.
  • Amounts of the Docket No.: 4305PCT additional organism, such as Lactobacilli, can vary. It is usually preferred that at least 4 billion colony forming units per gram of microorganism used for each 100 grams of total composition
  • Lactobacilli are present at birth as part of the intestinal microflora. This microflora is constantly changing depending on lifestyle, diet and influence from the environment. Lactobacilli are involved in various metabolic functions, and can improve enhance bioavailability. They can also control fermentative production of amine indole.
  • the microorganism solution Due to the medium used to grow the microorganisms, the microorganism solution will usually be in the form of an aqueous mixture or solution.
  • the microorganism solution When the microorganism solution is in the form of an aqueous solution, it is preferred that the microorganism solution be dehydrated after fermentation has taken place and the active ingredient has been bound by the glycoprotein matrix.
  • Methods of dehydrating solutions are known in the art. For example, such methods include freeze- drying, spray drying, open air drying, and drum drying. Spray drying is preferred. A longer dry time may be necessary depending on various factors, such as total water content, equipment used, and atmospheric humidity. However, after dehydrating the microorganism solution, the resulting product should be a fine powder..
  • the microorganism solution can be homogenized to produce a more uniform product. The homogenization is performed after the production of glycoprotein matrix, usually before dehydrating the microorganism solution.
  • homogenization can be performed by a homogenization pump, shearing pump or, if produced in a small batch, a blender.
  • the microorganisms are deactivated before dehydrating, preferably by raising the temperature of the microorganism solution.
  • the preferred temperature and conditions for stopping the fermentation in a mixture containing Saccharomyces cervisiae and Lactobacillus bacteria is heating the mixture to approximately 160 to 170° F. for approximately three hours with stirring.
  • binding an active ingredient to a glycoprotein matrix as in the composition described can increase the bioactivity of the active ingredient.
  • a separate embodiment of the invention includes a method for increasing the bioactivity of an active ingredient by binding the active ingredient with a glycoprotein matrix.
  • the glycoprotein matrix Docket No.: 4305PCT composition of the invention will allow the active ingredient to have an increased effect on the organism to which the composition is applied.
  • binding the active ingredient to a glycoprotein matrix as in the composition of the invention can increase the stability of the active ingredient. Therefore, a separate embodiment of the invention includes a method for increasing the stability of an active ingredient by binding the active ingredient with a composition of the invention.
  • the one or more glycoprotein matrix is present in amount from about 0.1 to about 10 wt.% of the personal care composition.
  • the one or more glycoprotein matrix is present in amount from about 0.1 to about 0.5 wt.%, from about 0.6 to about 1 wt.%, from about 1.1 to about 1.5 wt.%, from about 1.6 to about 2 wt.%, from about 2.1 to about 2.5 wt.%, from about 2.6 to about 3 wt.%, from about 3.1 to about 3.5 wt.%, from about 3.6 to about 4 wt.%, from about 4.1 to about 4.5 wt.%, from about 4.6 to about 5 wt.%, from about 5.1 to about 5.5 wt.%, from about 5.6 to about 6 wt.%, from about 6.1 to about 6.5 wt.%, from about 6.6 to about 7 wt.%, from about 7.1 to about 7.5 wt.%, from about 7.6 to about 8 wt.%, from about 8.1 to about 8.5 wt.%, from about
  • the cosmetically acceptable ingredient is selected from the group consisting of additive diluents, emollients, humectants, thickeners, preservatives, coloring agents, sunscreen agents, moisturizing agents, film formers/waterproofing agents, bioactive ingredients, pharmaceutical ingredients, pH adjusting agents, chelating agents, rheology modifying agents, fragrance agents, plant extracts, absorbents, vitamins, photo stabiliz-ing agents, sunscreen boosters, anti-oxidants, exfoliating agents, liquid carriers, waxes, conditioners, lubricants, anti-bacterial agents, anti-aging agents, and combinations thereof.
  • glycoprotein matrix bound to one or more biologically active ingredient of the present application can be employed in other non-limiting examples of personal care compositions that can comprise after-sun compositions, skin care compositions, oral care compositions, face care compositions, lip care compositions, eye care compositions, body care composi-tions, nail care Docket No.: 4305PCT compositions, anti-aging compositions, insect repellants, deodorant compositions, color cosmetic compositions, color-protection compositions, self-tanning compositions, and foot care compositions.
  • personal care compositions can comprise after-sun compositions, skin care compositions, oral care compositions, face care compositions, lip care compositions, eye care compositions, body care composi-tions, nail care Docket No.: 4305PCT compositions, anti-aging compositions, insect repellants, deodorant compositions, color cosmetic compositions, color-protection compositions, self-tanning compositions, and foot care compositions.
  • the skin care composition of the present application can be sunscreen composition, dermatological composition or a cosmetic composition.
  • the skin care/sunscreen compositions of the present application can exist in the form of a gel, a balm, a cream-in-gel, a balm-in-gel, a stick, a lotion, a foam, a foam cream, a cream, a moisturizer, a spray, an ointment, and a lamellar gel.
  • sun-screen or skin care composition forms include: solutions, oils, solids, liquids, powders, gels, pastes, waxes, aerosols, mists, roll- ans, milks, emulsions, wipes, oil-in-water emulsion, water-in-oil emulsion, an oil-water-oil emulsion, a water-oil-water emulsion, a water-in-silicone emulsion, an oily solution, a lipid fusion, a hydro-alcoholic gel, an anhydrous gel, an aqueous gel, an alcoholic solutions or a hydro-alcoholic solution, suspensions, microemulsions, dis-persions, microencapsulated products, tonics, mists, recon-stitutable products, peels, soaps, mousses, glues, pomades, spritzes, putties, lacquers, serums, perms, powders, pencils, flakes, blush, highlighters, bronzers
  • glycoprotein matrix bound to one or more biologically active ingredient of the present application can be employed in other non-limiting examples of personal care compositions that can comprise after-sun compositions, skin care compositions, oral care compositions, face care compositions, lip care compositions, eye care compositions, body care composi-tions, nail care compositions, anti-aging compositions, insect repellants, deodorant compositions, color cosmetic compositions, color-protection compositions, self-tanning compositions, and foot care compositions.
  • personal care compositions can comprise after-sun compositions, skin care compositions, oral care compositions, face care compositions, lip care compositions, eye care compositions, body care composi-tions, nail care compositions, anti-aging compositions, insect repellants, deodorant compositions, color cosmetic compositions, color-protection compositions, self-tanning compositions, and foot care compositions.
  • UV-A or UV-B based sunscreen compounds include but not limited to p-aminoben-zoic acid and its derivatives, anthranilates, benzophenones, camphor derivatives, cinnamic derivatives, dibenzoyl methane, diphenyl acrylate derivatives, salicylic derivatives, Docket No.: 4305PCT triazine derivatives, benzimidazole compounds, bis-benzoazolyl derivatives, methylene bis- (hydroxyphenylbenzotriazole) compounds, sunscreen polymers, silicones, and mixtures thereof.
  • Examples of physical sun blockers would include but not limited to cerium oxides, chromium oxides, cobalt oxides, iron oxides, red petrolatum, silicone-treated titanium dioxides, titanium dioxides, zinc oxides, and/or zirconium oxides and mixtures thereof
  • Suitable sunscreen agents for preparing the sunscreen composition of the present application would include but not limited to methoxydibenzoylmethane; octyl salicy-late; pentyl dimethyl PABA; octyl dimethyl PABA; benzophenone-1; benzophenone-6; 2-(2H-benzotriazole- 2-yl)-4, 6-di-tert-pentylphenol; ethyl-2-cyano-3,3-diphenylacrylate; homomethyl salicylate (homosalate ); bis-ethylhexyloxyphe-nol methoxyphenyl triazine; methyl-(1,2,2,6,6-penta
  • the sunscreen compositions of present application has a sun protection factor (SPF) of at least about 10.
  • SPPF sun protection factor
  • Other non-limiting ranges of SPF of the sunscreen composition would include at least 11, at least 12, at least 13, at least 14, at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 21, at least 22, at least 23, at least 24, at least 25, at least 26, at least 27, at least 28, at least 29, at least 30, at least 26, at least 27, at least 28, at least 29, at least 30, at least 31, at least 32, at least 33, at least 34, at least 35, at least 36, at least 37, at least 38, at least 39, at least 40, at least 41, at least 42, at least 43, at least 43, at least 44, at least 45, at least 46, at least 47, at least 48, at least 49, at least 50, at least 51, at least 52, at least 53, at least 54, at least 55, at least 56, at least 57, at least 58, at least 59, or at least 60.
  • At least one primary surfactant, co- surfactant or a system of surfactants comprising at least one primary surfactant and at least one co- surfactant are employed to prepare the sunscreen or skin care compositions, and wherein said primary surfactants, co-surfactants or a system surfactant can be selected from the group consisting of anionic surfactants, cationic surfactants, non-ionic surfactants, zwitterionic sur-factants and amphoteric surfactants.
  • the range of surfactants can be from 0.1 wt.% to 20 wt.% based on the total weight of the composition.
  • surfactants are from 0.1 wt.% to 5 wt.%, from 5 wt.% to 10 wt.%, from 10 wt.% to 15 wt. %, or from 15 wt. % to 20 wt. % of total weight of the composition.
  • the contemplated surfactants for use herein are as follows: [0079] (A) Anionic Surfactants: Anionic surfactants are particularly useful in accordance with certain embodiments of the present application.
  • Surfactants of the anionic type include: Docket No.: 4305PCT [0080]
  • Sulfonates and Sulfates include sulfonates and sulfates such as alkyl sul-fates, alkylether sulfates, alkyl sulfonates, alkylether sul-fonates, alkylbenzene sufonates, alkylbenzene ether sulfates, alkylsulfoacetates, secondary alkane sulfonates, secondary alkylsulfates, alkyl sulfosuccinates and the like.
  • anionic surfactants include water-soluble salts of higher fatty acid monoglyceride monosulfates, such as the sodium salt of the monosulfated monoglyceride of hydrogenated coconut oil fatty acids, higher alkyl sulfates such as sodium lauryl sulfate, alkyl aryl sulfonates such as sodium dodecyl benzene sulfonate, higher alkyl sulfoacetates, higher fatty acid esters of 1,2-dihydroxy propane sulfonate, and the substantially saturated higher aliphatic acyl amides of lower aliphatic amino carboxylic acid compounds, such as those having 12 to 16 carbons in the fatty acid, alkyl or acyl radicals, and the like.
  • higher alkyl sulfates such as sodium lauryl sulfate
  • alkyl aryl sulfonates such as sodium dodecyl benzene sulfonate
  • Suitable anionic surfactants also include phosphates such as alkyl phosphates, alkylether phosphates, aralkylphosphates, and aralkylether phosphates.
  • phosphates such as alkyl phosphates, alkylether phosphates, aralkylphosphates, and aralkylether phosphates.
  • examples include a mixture of mono-, di- and tri-(alkyltetraglycolether)-o-phosphoric acid esters generally referred to as trilaureth-4-phosphate commercially available under the trade designation HOS-TAPHAT 340KL from Clariant Corp., as well as PPG-5 ceteth 10 phosphate available under the trade designation CRODAPHOS SG from Croda Inc., Parsipanny, N.J.
  • Suitable anionic surfactants also include amine oxides.
  • amine oxide surfactants include lauryldimethylamine oxide, laurylamidopropyldimethylamine oxide, and/or cetyl amine oxide.
  • Amphoteric Surfactants Surfactants of the amphoteric type include surfactants having tertiary amine groups which may be protonated as well as quaternary amine containing zwitterionic surfactants.
  • amphoteric surfactants include, but are not limited to: certain betaines such as cocobetaine and cocamidopropyl betaine; monoacetates such as sodium lauroamphoacetate; diacetates such as di sodium lauroamphoacetate; amino and alkylaminopropionates such as lauraminopropionic acid.
  • Ammonium Sulfonate Amphoterics These classes of amphoteric surfactants are often referred to as "sultaines" or "sulfobetaines” for example, cocamidopropy-lhydroxysultaine.
  • Nonionic Surfactants of the non-ionic type that may be particularly useful include: [0087] (1) Polyethylene oxide extended sorbitan mono-alkylates (i.e. Polysorbates ); (2) Polyalkoxylated alkanols; (3) Polyalkoxylated alkylphenols include polyethoxylated octyl or nonyl phenols having HLB values of at least about 14, which are commercially available under the trade des-ignations ICONOL and TRITON; (4) Polaxamers. Surfac-tants based on block copolymers of ethylene oxide (EO) and propylene oxide (PO) may also be effective.
  • EO ethylene oxide
  • PO propylene oxide
  • Both EO- PO-EO blocks and PO-EO-PO blocks are expected to work well as long as the HLB is at least about 14, and preferably at least about 16.
  • Such surfactants are commercially available under the trade designations PLURONIC and TETRONIC from BASF; (5) Polyalkoxylated esters- Polyalkoxylated glycols such as ethylene glycol, propylene glycol, glycerol, and the like may be partially or completely esterified, i.e. one or more alcohols may be esterified, with a (C5 to C22) alkyl carboxylic acid.
  • Such polyethoxylated esters having an HLB of at least about 14, and preferably at least about 16, may be suitable for use in compositions of the present invention;
  • Surfactants of the cat-ionic type that may be useful include but are not limited to, primary amines, secondary amines, tertiary amines, quater-nary amines, alkanolamines, mono-alkyl alkanolamines, di-alkyl alkanolamines, tri-alkyl alkanolamines, alkyl mono alkanolamines, alkyl di-alkanolamines, alkylamines, mono-alkyl amines, di-alkyl amines, tri-alkylamines, alkoxylated amines, alkyl and aryl amine alkoxylates, methoxylated alkylamines, ethoxylated alkylamines, alkoxylated alkano-lamines, alkyl alkanolamines, alkoxylated ethylene diamine derivatives, alkyl/aryl/arylalky
  • Preferred cat-ionic surfactants of the present invention include, but are not limited to, (a) alkyl alkanolamines; and (b) alkyl tertiary amines. Additional information on useful cationic surfac-tants for the purpose of present invention is set forth in McCutcheon's Detergents and Emulsifiers, North American Ed., 1982 and Kirk- Othmer, Encyclopedia of Chemical Technology, 3rd Ed., Vol. 22, pp. 346-387, the contents of which are incorporated herein by reference.
  • Suitable emulsifiers include the following classes of ethers and esters: ethers of polyglycols and of fatty alcohols, esters of polyglycols and of fatty acids, ethers of polyglycols and of fatty alcohols which are glycosylated, esters of polyglycols and of fatty acids which are Docket No.: 4305PCT glycosylated, ethers of C12-30 alcohols and of glycerol or of polyglycerol, esters of C12-30 fatty acids and of glycerol or of polyglycerol, ethers of oxyalkylene-modified C12-30 alco-hols and of glycerol or polyglycerol, ethers of C 12-30 fatty alcohols comprising and of sucrose or of glucose, esters of sucrose and of C12-30 fatty acids, esters of pentaerythritol and of C12-30 fatty acids, esters of sorbitol and
  • Linear or branched type silicone emulsifiers may also be used.
  • Particularly useful polyether modified silicones include KF-6011, KF-6012, KF-6013, KF-6015, KF-6015, KF-6017, KF-6043, KF-6028, andKF-6038 from Shin- Etsu.
  • the polyglycerolated linear or branched siloxane emulsifiers including KF-6100, KF-6104, and KF-6105 from Shin-Etsu.
  • Emulsifiers also include emulsifying silicone elastomers. Suitable emulsifying sili-cone elastomers may include at least one polyalkyl ether or polyglycerolated unit.
  • cosmetically acceptable ingredient or dermatologically acceptable ingredient means any ingredient/compound or mixture of ingredients/compounds or compositions that are typically employed to produce other desirable effects in skin care/sunscreen compositions.
  • the preferred cosmetically/dermatologically acceptable excipients include but not limited to preservatives, antioxidants, chelating agents, sunscreen agents, proteins, amino acids, vitamins, dyes, hair coloring agents, plant extracts, plant derivatives, plant tissue extracts, plant seed extracts, plant oils, botani-cals, botanical extracts, humectants, fragrances, perfumes, oils, emollients, lubricants, butters, penetrants, thickeners, viscosity modifiers, thickeners, polymers, resins, hair fixa-tives, film formers, surfactants, detergents, emulsifiers, opacifying agents, volatiles, propellants, liquid vehicles, carriers, salts, pH adjusting agents, neutralizing agents, buffers, hair
  • Suitable emulsifiers include the following classes of ethers and esters: ethers of polyglycols and of fatty alcohols, esters of polyglycols and of fatty acids, ethers of polyglycols and of fatty alcohols which are glycosylated, esters of polyglycols and of fatty acids which are Docket No.: 4305PCT glycosylated, ethers of C12-30 alcohols and of glycerol or of polyglycerol, esters of C12-30 fatty acids and of glycerol or of polyglycerol, ethers of oxyalkylene-modified C12-30 alco-hols and of glycerol or polyglycerol, ethers of C 12-30 fatty alcohols comprising and of sucrose or of glucose, esters of sucrose and of C12-30 fatty acids, esters of pentaerythritol and of C12-30 fatty acids, esters of sorbitol and
  • Linear or branched type silicone emulsifiers may also be used.
  • the skin care and sunscreen composition of present application can be preserved by adding minor quantity of preservatives to the compositions.
  • preservatives can be selected from, but are not limited to triazoles, imidazoles, naphthalene derivatives, benzimidazoles, morphline deriva-tives, dithiocarbamates, benzisothiazoles, benzamides, boron compounds, formaldehyde donors, isothiazolones, thiocyanates, quaternary ammonium compounds, iodine derivates, phenol derivatives, micobicides, pyridines, dialkylthiocarbamates, nitriles, parabens, alkyl parabens and salts thereof.
  • the range of preservative employed is in the range of from about 0.01 wt. % to about 10 wt. %.
  • the preferred fatty substance based additive/excipient for the present application include fatty alcohols, natural and synthetic waxes, ceramides, mineral oils, veg-etable oils, animal oils, synthetic oils.
  • the other preferred fatty substance is isododecane, hydrogenated polyisobutene, squalane, isononyl isononanoate, cyclotetra- and -pentadi-methicones, phenyltrimethicone, ethylene homopolymers, ethoxylated fats and oils, fluoroalkanes, seracite, shea butter, arachidyl propionate alone or in combination.
  • waxes mention may be made, for example, of P. D. Dorgan, Drug and Cosmetic Industry, December 1983, pp.30-33.
  • Moisturizers employed in the present application would include glycols, glycerols, propylene glycol, diethylene glycol monoethyl ether, sorbitol, sodium salt of pyroglutamic acid, glycerol, glycerol derivatives, glycerin, trehalose, sorbitol, maltitol, dipropylene glycol, 1,3- butylene glycol, sodium hyaluronate, and the like.
  • humectants which can be incorporated into a product of the present application are glycerine, propylene glycol, poly-propylene glycol, polyethylene glycol, lactic acid, sodium lactate, pyrrolidone carboxylic acid, urea, phospholipids, collagen, elastin, ceramides, lecithin sorbitol, PEG-4, and mixtures Docket No.: 4305PCT thereof.
  • Additional suitable moisturizers are poly-meric moisturizers that belong to water soluble and/or water swellable in nature. Polysaccharides such as hyaluronic acid, chitosan can also be employed along with moisturizers of the present application as binder to enhance their property.
  • the range of moisturizer is from about 0.1 wt. % to about 10 wt. %.
  • the suitable solvent of the present application can consist of water, a cosmetically/dermatologically acceptable solvent, or a blend of water and a cosmetically/dermatologically acceptable solvent, such as a lower alcohol composed of C 1 to C 4 , such as ethanol, isopropanol, t-butanol, n-bu-tanol, alkylene glycols such as propylene glycol, and glycol ethers.
  • the most preferred solvents of the present applica-tion would include water, ethanol and/or iso-propanol.
  • C1-C6 alcohols such as ethanol, propanol, isopropanol, butanol, hexanol, and mixtures thereof
  • aromatic alcohols such as benzyl alcohol, cycloaliphatic alcohols, such as cyclohexanol, and the like
  • saturated C12-C30 fatty alcohol such as lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, and the like.
  • Non-limiting examples of polyols include polyhydroxy alcohols, such as glycerin, propylene glycol, butylene glycol, hexylene glycol, C 2 -C 4 alkoxylated alcohols and C 2 -C 4 alkoxylated polyols, such as ethoxy-lated, propoxylated, and butoxylated ethers of alcohols, dials, and polyols having about 2 to about 30 carbon atoms and 1 to about 40 alkoxy units, polypropylene glycol, polybutylene glycol, and the like.
  • polyhydroxy alcohols such as glycerin, propylene glycol, butylene glycol, hexylene glycol, C 2 -C 4 alkoxylated alcohols and C 2 -C 4 alkoxylated polyols, such as ethoxy-lated, propoxylated, and butoxylated ethers of alcohols, dials, and polyols having about 2 to about 30 carbon atom
  • Non-limiting examples of non-aqueous auxiliary solvents include silicones, and silicone derivatives, such as cyclomethicone, and the like, aliphatic solvents such as cyclohexane and heptane, ketones such as acetone and methyl ethyl ketone, and mixtures thereof; ethers such as diethyl ether, dimethoxymethane, and mixtures thereof, natural and synthetic oils and waxes, such as vegetable oils, plant oils, animal oils, essential oils, mineral oils, C7-C40 isoparaflins, alkyl carboxylic esters, such as ethyl acetate, amyl acetate, ethyl lactate, and the like, jojoba oil, shark liver oil, and the like [0096]
  • the alkaline pH adjusting agents such as alkali metal hydroxides, for example, sodium hydroxide, and potassium hydroxide; ammonium hydroxide; organic bases, such as triethanolamine, diiso
  • Acidic pH adjusting agents can be organic acids, including amino acids, and inorganic mineral acids.
  • Non-limiting examples of acidic pH adjusting agents include acetic acid, citric acid, fumaric acid, glutamic acid, glycolic acid, hydrochloric acid, lactic acid, nitric acid, phosphoric acid, sodium bisulfate, sulfuric acid, tartaric acid, and the like, and mixtures thereof.
  • the desired pH of the personal care composition is in the range of from about 2 to about 13, and in some embodiment, it is preferably between about 4 to about 8.
  • the utility levels of the pH modifying agent can be present in an effective amount required to achieve the desired pH level.
  • the coloring agents, colorants or dyes used herein include natural foods colors and dyes suitable for food, drug and cosmetic applications.
  • colorants are also known as FD & C, and D&C dyes and lakes and are preferably water-soluble in nature.
  • FD&C and D&C dyes and lakes are preferably water-soluble in nature.
  • These coloring agents may be incorporated in amount up to about 3%, more particularly up to about 2%, and in some cases less than about 1 % by weight of the personal care compositions.
  • a perfume or fragrance obtained from natural or synthetic source can be employed in the present skin/ sunscreen composition.
  • the fragrance can be used along with a suitable solvent, diluents or carrier.
  • Fragrances may be added in any conventionally known method, for example, admixing to a composition or blending with other ingredi-ents used to form a composition, in amounts which are found to be useful to increase or impart the desired scent charac-teristics to the disinfectant or cleaning compositions.
  • Fragrances for the present application can be one or more selected from the following non-limiting group of com-pounds such as essential oils, absolutes, resinoids, resins, concretes, hydrocarbons, alcohols, aldehydes, ketones, ethers, acids, esters, acetals, ketals, nitriles, including satu-rated and unsaturated compounds and aliphatic, carbocyclic and heterocyclic compounds.
  • sequestering agent or "chelating agent” as used herein relates to a compound which is capable of bonding or complexing a metal ion between two or more atoms of the compound, thereby neutralizing or controlling harmful effects of such metal ions. Wherein holding or bonding of a metal ion is through combination of one or more different types of bonds including Docket No.: 4305PCT coordination and/or ionic bonds. Further, the information on sequestering and chelating agents that are considered for the present applica-tion is duly disclosed in T. E. Furia, CRC Handbook of Food Additives, rd Edition, pp. 271-294 (1972), and M. S Peterson and A. M.
  • Non-limiting examples of suitable thickeners and/ or viscosifiers include: Acetamide MEA; acrylamide/ ethalkonium chloride acrylate copolymer; acrylamide/ethyl-trimonium chloride acrylate/ethalkonium chloride acrylate copolymer; acryl amides copolymer; acrylamide/sodium acrylate copolymer; acrylamide/sodium acryloyldimethyltaurate copolymer; acrylates/acetoacetoxyethyl methacry-late copolymer; acrylates/beheneth-25 methacrylate copolymer; acrylates/C10-C30 alkyl acrylate crosspolymer; acrylates/ceteth-20 itaconate copolymer; acrylates/ceteth-20 methacrylate copo
  • the pH of the composition is in the range of from about 2 to about 12.
  • Other possible ranges of pH can be about 2 to about 4, about 4 to about 6, about 6 to about 8, about 8 to about 10, about 10 to about 12.
  • the amount of one or more cosmetically acceptable ingredient is from about 0.01 to about 99.9 wt.% of one or more cosmetically acceptable ingredient.
  • the amount of one or more cosmetically acceptable ingredient is from about 0.01 to about 10 wt.%, from about 10.1 to about 20 wt.%, from about 20.1 to about 30 wt.%, from about 30.1 to about 40 wt.%, from about 40.1 to about 50 wt.%, from about 50.1 to about 60 wt.%, from about 60.1 to about 70 wt.%, from about 70.1 to about 80 wt.%, from about 80.1 to about 90 wt.%, from about 90.1 to about 99.9 wt.% of one or more cosmetically acceptable ingredient.
  • glycoprotein matrix is bound to one or more biologically active ingredient.
  • the biologically active ingredient is selected from the group consisting of biotin, folic acid, vitamin B-12, vitamin D-3, vitamin-K-1, selenium, molybdenum, iodine, copper, chromium, vitamin B1, vitamin B2, niacinamide, vitamin B6, pantothenic acid, vitamin C, beta-Carotene, vitamin A Palmitate, vitamin E, iron, magnesium, manganese, zinc, calcium, choline, 4-aminobenzoic acid (PABA) and combinations thereof.
  • PABA 4-aminobenzoic acid
  • the composition can contain essentially any percentage of biologically active ingredient as desired.
  • the percentage of active ingredient can vary between 0.01 and 99 wt% by total weight of glycoprotein matrix bound to one or more biologically active ingredient.
  • the amount of one or more cosmetically acceptable ingredient is from about 0.01 to about 10 wt.%, from about 10.1 to about 20 wt.%, from about 20.1 to about 30 wt.%, from about 30.1 to about 40 wt.%, from about 40.1 to about 50 wt.%, from about 50.1 to about 60 wt.%, from about 60.1 to about 70 wt.%, Docket No.: 4305PCT from about 70.1 to about 80 wt.%, from about 80.1 to about 90 wt.%, from about 90.1 to about 99 wt.%, by total weight of glycoprotein matrix.
  • a method of delivering an active ingredient to a host includes binding a glycoprotein matrix to the active ingredient to form a glycoprotein matrix personal care composition.
  • the personal care composition is then delivered to the host.
  • the host is a mammal. Mammals include, for example, humans, as well as pet animals such as dogs and cats, laboratory animals such as rats and mice, and farm animals such as horses and cows. Humans are most preferred.
  • a personal care composition comprising a vitamin bound by a glycoprotein matrix, wherein said composition is obtained by a process comprising i) adding a vitamin to a water based microorganism solution containing carbohydrates and Saccharomyces cerevisiae, and fermenting to obtain a first fermented solution, ii) adding a proteolytic enzyme to the first fermented solution obtained from part (i), iii) adding Lactobacillus acidophilus and Bacterium bifidum to the first fermented solution containing the proteolytic enzyme of part (ii) and fermenting to obtain a final fermented solution; and iv) drying a final fermented solution to obtain vitamin bound by a glycoprotein matrix.
  • Example 1 Aqueous Suspension Composition is prepared using glycoprotein matrix bound to vitamin E and below ingredients I ngredients Quantity ( wt.
  • Example 5 Water-in-oil emulsion
  • a water-in-oil emulsion gel cream was prepared using the following ingredients. Ingredients Concentrations (wt.
  • Phase B Heat the ingredients up to 80C. Add the phase b ingredients to phase a, homogenize at 80 deg C for 2 minutes.
  • Phase C Premix Amodimethicone (and) Cetrimonium Chloride (and) Trideceth-12 Fluid and Dimethicone in a separate vessel and add to the main batch. Homogenize for 2 min.
  • Phase d Lower temperature to below 45C. Add ingredients in phase D in order and mix until homogenous, continue mixing and cool further below 30 deg C.
  • compositions and methods of the disclosed and/or claimed inventive concept(s) have been described in terms of particular aspects, it will be apparent to those of ordinary skill in the art that variations may be applied to the compositions and/or methods and in the steps or in the sequence of steps of the method described herein without departing from the concept, spirit and scope of the disclosed and/or claimed inventive concept(s). All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the disclosed! and/or claimed inventive concept(s).

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Abstract

L'invention concerne une composition de soins personnels qui comprend un composé biologiquement actif lié par une matrice glycoprotéique. L'invention concerne également un procédé de fabrication d'une composition de soins personnels de l'invention. La matrice glycoprotéique peut être formée en permettant la croissance de bactéries produisant des glycoprotéines en présence de l'ingrédient actif. La composition de soins personnels de l'invention permet la mise en oeuvre d'un procédé permettant d'augmenter la stabilité et la bioactivité du principe actif. L'invention concerne également un procédé permettant l'application d'un principe actif chez un hôte à l'aide d'une composition de l'invention.
PCT/US2023/073764 2022-09-12 2023-09-08 Composition de soins personnels à matrice glycoprotéique et procédés associés Ceased WO2024158442A1 (fr)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020182183A1 (en) * 2001-01-09 2002-12-05 Pharmachem Laboratories, Inc. Glycoprotein matrix compositions and methods related thereto
US20160256379A1 (en) * 2013-10-31 2016-09-08 La Prairie Group Ag Improved protection against extrinsic skin aging
CN109431856A (zh) * 2018-12-17 2019-03-08 广州暨南大学医药生物技术研究开发中心 一种模拟细胞外基质的冻干产品

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020182183A1 (en) * 2001-01-09 2002-12-05 Pharmachem Laboratories, Inc. Glycoprotein matrix compositions and methods related thereto
US20160256379A1 (en) * 2013-10-31 2016-09-08 La Prairie Group Ag Improved protection against extrinsic skin aging
CN109431856A (zh) * 2018-12-17 2019-03-08 广州暨南大学医药生物技术研究开发中心 一种模拟细胞外基质的冻干产品

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