WO2024152387A1 - Interventional heating micro-needle - Google Patents

Abstract

An interventional heating micro-needle, comprising a needle tube (103) for being inserted into human tissue, wherein the needle tube (103) is used as a grounding electrode by means of a connecting wire; a discharge electrode (102) is embedded by means of filling and coating the inner wall of the needle tube (103) with a high-temperature-resistant insulation coating (105); the discharge electrode (102) and the needle tube (103) are respectively connected to a high-voltage electrode and a ground electrode of a high-voltage high-frequency power source (100); a gap is reserved between the discharge electrode (102) and the needle tube (103) to form an open circuit; and after the power source is turned on, air in the gap is ionized to form a micro-arc plasma groove (104). In the micro-needle, air in the gap between the discharge electrode (102) and the grounding electrode is ionized to form micro-arc plasma discharge, and the discharge electrode may be located at an end and may also be distributed in the tube at an interval. By means of controlling a discharge power, the temperature at a discharge part of the needle tube (103) can be controlled, such that after the micro-needle is inserted into the body, the temperature at the surface of the micro-needle can be controlled by means of controlling a micro-plasma discharge current, thereby achieving the aims of killing cancer cell tissue and plaque ablation.

Description

An interventional heating microneedle Technical Field

The invention relates to the technical field of medical devices, in particular to an interventional heating microneedle.

Background technique

Plasma is highly valued in medical surgical treatment. For example, the plasma cryoablation surgery, which has been popular since 2011, is used to treat rhinitis, pharyngitis, snoring and other diseases. The principle of plasma cryoablation surgery is to form a thin plasma layer between the electrode and the tissue. This is a direct discharge of the electrode to the human tissue. The ions in the layer are accelerated by the electric field and transfer energy to the tissue. At low temperatures (40℃-70℃), the molecular bonds between cells are opened, and the cells in the target tissue are decomposed into carbohydrates and oxides, causing the liquefaction and ablation of the diseased tissue, which is called plasma ablation, thereby achieving the effect of reducing the volume of the target tissue.

technical problem

Currently, there is a lack of a device that can quickly hold and insert microneedles into human tissues, so that plasma is generated at the end of the microneedle or evenly distributed inside the microneedle, thereby accurately controlling the temperature on the microneedle and performing plasma thermal ablation.

It should be noted that the information disclosed in the above background technology section is only used to enhance the understanding of the background of the present disclosure, and therefore may include information that does not constitute the prior art known to ordinary technicians in the field.

Technical Solutions

The purpose of the present application is to provide an interventional heating microneedle, which at least to some extent overcomes the problem that the prior art cannot accurately adjust the precise heating of different positions of the microneedle, and ionizes the air in the gap between the discharge electrode and the ground electrode to form a micro-arc plasma discharge. The discharge electrode can be distributed at the end or in the gap interval in the tube. By controlling the discharge power, the temperature of the discharge part of the needle tube can be controlled, so that after the microneedle is inserted into the body, the temperature of the microneedle surface at different positions can be controlled by controlling the microplasma discharge current, thereby achieving the purpose of fixed-point or segmented killing of cancer cell tissue and plaque ablation. Other features and advantages of the present application will become apparent through the detailed description below, or partially learned through the practice of the present invention.

According to one aspect of the present application, an interventional heating microneedle is provided, comprising a needle tube for inserting into human tissue, the needle tube being used as a ground electrode through a connecting wire, a discharge electrode being embedded in the inner wall of the needle tube by filling and coating with a high-temperature resistant insulating coating, the discharge electrode and the needle tube being respectively connected to a high-voltage electrode and a ground electrode of a high-voltage and high-frequency power supply, and a gap being left between the discharge electrode and the needle tube to form an open circuit, and the air in the gap being ionized to form a micro-arc plasma slot.

In one embodiment of the present application, the needle tube is configured as a stainless steel tube, one end of which is configured as a conical structure, and the outer diameter of the heating needle tube is configured to be less than 2 mm.

In one embodiment of the present application, an insulating hand-held tube is sleeved on one end of the needle tube away from the cone head, and the insulating hand-held tube is configured to be a ceramic part or a plastic material part.

In one embodiment of the present application, the discharge electrode is configured as a metal part, and the metal part is a stainless steel part, an aluminum part or a copper part.

In one embodiment of the present application, the high-frequency high-voltage power supply is a power supply with a frequency range of 1 to 200 KHz.

In one embodiment of the present application, a power adjustable switch is provided on the high-frequency and high-voltage power supply, and the power adjustable switch is configured as a digital switch button.

In one embodiment of the present application, the high temperature resistant insulating coating is configured as a temperature resistant ceramic layer or a temperature resistant insulating paint layer.

In one embodiment of the present application, a space not filled with a high temperature resistant insulating coating is left at the conical head of the needle tube to form a micro-arc plasma slot, and one end of the discharge electrode protrudes into the micro-arc plasma slot.

In one embodiment of the present application, a plurality of micro-arc plasma slots are arranged at equal intervals in the needle tube, both sides of each micro-arc plasma slot are filled with high-temperature resistant insulating coating intervals, and the lines of the discharge electrode pass through each micro-arc plasma slot.

In one embodiment of the present application, the line center of the discharge electrode and the center of the needle tube are located on the same horizontal axis.

Beneficial Effects

The present application provides an interventional heating microneedle, including a needle tube for inserting into human tissue, the needle tube is used as a ground electrode through a connecting wire, a discharge electrode is embedded in the inner wall of the needle tube by filling and coating a high-temperature resistant insulating coating, the discharge electrode and the needle tube are connected to a high-frequency high-voltage power supply through a connecting wire, and a gap is left between the discharge electrode and the heating needle tube to form an open circuit, and the air in the gap is ionized to form a micro-arc plasma slot for tissue thermal therapy. An insulating hand-held tube is used in conjunction with a heating needle tube, which is convenient for the operator to hold and move the needle tube to puncture and intervene in human tissue, and the needle tube is set as a stainless steel tube ground electrode, and the internal insulation is embedded with a discharge electrode, and two motors are powered by a high-voltage high-frequency power supply with a switch, and the air is ionized in the gap between the discharge electrode and the ground electrode to form a micro-arc plasma discharge, and the discharge electrode can be distributed at the end or in the gap in the tube. By controlling the discharge power, the temperature of the discharge part of the needle tube can be controlled, so that after the microneedle is inserted into the body, the temperature of the microneedle surface can be controlled by controlling the microplasma discharge current, thereby achieving the purpose of killing cancer cell tissue and plaque ablation.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a schematic diagram of the internal structure of the heating needle tube of the present invention.

FIG. 2 is a schematic diagram of the front view of the heating needle tube of the present invention.

FIG. 3 is a schematic diagram of a structure provided by an embodiment of the present invention.

FIG. 4 is a schematic structural diagram of another embodiment of the present invention.

In the figure:

100. High frequency and high voltage power supply;

101. Insulated hand-held tube;

102. Discharge electrode;

103. Needle;

104. Micro arc plasma tank;

105. High temperature resistant insulation coating;

106. Power adjustable switch.

Embodiments of the present invention

Various exemplary embodiments of the present application will now be described in detail with reference to the accompanying drawings. It should be noted that unless otherwise specifically stated, the relative arrangement of components and steps, numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present application.

At the same time, it should be understood that for the convenience of description, the sizes of the various parts shown in the drawings are not drawn according to the actual proportional relationship.

The following description of at least one exemplary embodiment is merely illustrative in nature and is not intended to limit the present application, its application, or uses.

It should be noted that like reference numerals and letters refer to similar items in the following figures, and therefore, once an item is defined in one figure, it need not be further discussed in subsequent figures.

In addition, the technical solutions between the various embodiments of the present application can be combined with each other, but it must be based on the fact that ordinary technicians in the field can implement it. When the combination of technical solutions is mutually contradictory or cannot be implemented, it should be deemed that such combination of technical solutions does not exist and is not within the scope of protection required by this application.

It should be noted that those skilled in the art will easily think of other embodiments of the present application after considering the specification and practicing the invention disclosed herein. The present application is intended to cover any modification, use or adaptation of the present application, which follows the general principles of the present application and includes common knowledge or customary technical means in the art that are not disclosed in the present application. The specification and examples are only regarded as exemplary, and the true scope and spirit of the present application are indicated by the claims.

It should be understood that the present application is not limited to the precise structures described below and shown in the drawings, and that various modifications and changes may be made without departing from the scope thereof. The scope of the present application is limited only by the appended claims.

The following describes the interventional heating microneedle according to the exemplary embodiment of the present application in conjunction with Figures 1 to 3. It should be noted that the following application scenarios are only shown to facilitate understanding of the spirit and principle of the present application, and the embodiments of the present application are not limited in this regard. On the contrary, the embodiments of the present application can be applied to any applicable scenario.

In one embodiment, the present application proposes an interventional heating microneedle, comprising a needle tube 103 for inserting into human tissue, wherein the needle tube 103 is configured as a stainless steel tube, one end of which is configured as a tapered structure, and the outer diameter of the needle tube 103 is configured to be less than 2 mm, and is used for puncturing interventional tissue;

In one implementation, an end of the needle tube 103 away from the cone head is sleeved with an insulating hand-held tube 101, which is configured as a ceramic part or a plastic material part, and is used by an operator to hold and move the heated needle tube 103 to puncture and intervene in human tissue.

By holding the insulating hand-held tube 101 made of ceramic or plastic material, the operator can conveniently operate the movable needle tube 103 without contact. The needle tube 103 with an outer diameter less than 2 mm is sharp and thin. The cone head of the needle tube 103 can easily pierce into the human tissue, allowing the needle body of the needle tube 103 to intervene in the lesion of the human tissue, laying the foundation for subsequent ionization of the tissue.

In one implementation, the needle tube 103 is connected to a wire as a ground electrode, and a discharge electrode 102 is embedded in the inner wall of the needle tube 103 by filling and coating a high-temperature resistant insulating coating 105. The discharge electrode 102 is set as a metal part, which is a stainless steel part, aluminum part or copper part, and is used for conducting electricity to ionize the air.

In one implementation, the high temperature resistant insulating coating 105 is configured as a temperature resistant ceramic layer or a temperature resistant insulating paint layer, which is used to insulate the spaced discharge electrodes 102 in the needle tube 103 and stably arrange the discharge electrodes 102 for ionization work.

In one implementation, the discharge electrode 102 and the needle tube 103 are respectively connected to the high-voltage electrode and the ground electrode of the high-frequency high-voltage power supply 100. The frequency range of the high-frequency high-voltage power supply 100 is 1 to 200 KHz, which is used to stably supply power to the discharge electrode 102 for ionization work; further, the high-frequency high-voltage power supply 100 is provided with a power adjustable switch 106, which is set as a digital switch button, and can be portable to turn on and off the power supply to control the progress of the ionization work.

In one implementation, a gap is left between the discharge electrode 102 and the needle tube 103 to form an open circuit, and the air in the gap is ionized to form a micro-arc plasma slot 104 .

In one implementation, in order to facilitate the manipulation of the needle tip of the needle tube 103 for efficient ionization treatment, a space is left at the conical head of the needle tube 103 that is not filled with the high-temperature resistant insulating coating 105, forming a micro-arc plasma slot 104, and one end of the discharge electrode 102 protrudes into the micro-arc plasma slot 104. The discharge electrode 102 protruding into the micro-arc plasma slot 104 can cause ionization between the discharge electrode 102 and the tissue involved at the needle tip when the needle tip intervenes in the tissue, and then precise ionization treatment is performed here.

In one implementation, the line center of the discharge electrode 102 and the center of the needle tube 103 are located on the same horizontal axis, and the outer surface of the discharge electrode 102 is evenly arranged in the space of the inner wall of the needle tube 103, so that the discharge electrode 102 evenly ionizes the gas in the surrounding space to avoid local unevenness that affects the control accuracy.

In the present application, after the needle tube 103 is inserted into the human tissue, the power adjustable switch 106 is used to ionize the air in the gap between the discharge electrode 102 and the stainless steel tube grounding electrode to form a micro-arc plasma discharge. The discharge electrode is at the end of the needle tube 103 to form a micro-arc plasma slot 104. The power of the high-frequency high-voltage power supply 100 is controlled by the power adjustable switch 106, and then the discharge power is controlled, and the temperature of the discharge part of the needle tube is controlled. When the needle tube 103 is inserted into the human tissue and the microneedle is inserted into the body, the temperature of the microneedle surface can be controlled by controlling the microplasma discharge current, thereby achieving the purpose of killing cancer cell tissue and ablating plaques.

In another embodiment, referring to FIG. 1 , FIG. 2 and FIG. 4 , the present application provides an interventional microneedle, comprising a needle tube 103 for inserting into human tissue, wherein the needle tube 103 is configured as a stainless steel tube, one end of which is configured as a conical structure, and a heating needle tube 103 is configured. The outer diameter of the needle tube 103 is less than 2 mm, and is used for puncturing interventional tissue;

In one implementation, an end of the needle tube 103 away from the cone head is sleeved with an insulating hand-held tube 101, which is configured as a ceramic part or a plastic material part, and is used by an operator to hold and move the needle tube 103 so as to puncture and intervene in human tissue.

By holding the insulating hand-held tube 101 made of ceramic or plastic material, the operator can conveniently operate the movable needle tube 103 without contact. The needle tube 103 with an outer diameter less than 2 mm is sharp and thin. The cone head of the needle tube 103 can easily pierce into the human tissue, allowing the needle body of the needle tube 103 to intervene in the lesion of the human tissue, laying the foundation for subsequent ionization of the tissue.

In one implementation, the needle tube 103 is connected to a wire as a ground electrode, and a discharge electrode 102 is embedded in the inner wall of the needle tube 103 by filling and coating a high-temperature resistant insulating coating 105. The discharge electrode 102 is set as a metal part, which is a stainless steel part, aluminum part or copper part, and is used for conducting electricity to ionize the air.

In one implementation, the high temperature resistant insulating coating 105 is configured as a temperature resistant ceramic layer or a temperature resistant insulating paint layer, which is used to insulate the spaced discharge electrodes 102 in the needle tube 103 and stably arrange the discharge electrodes 102 for ionization work.

In one implementation, the discharge electrode 102 and the needle tube 103 are respectively connected to the high-voltage electrode and the ground electrode of the high-frequency high-voltage power supply 100. The frequency range of the high-frequency high-voltage power supply 100 is 1 to 200 KHz, which is used to stably supply power to the discharge electrode 102 for ionization work; further, the high-frequency high-voltage power supply 100 is provided with a power adjustable switch 106, which is set as a digital switch button, and can be portable to turn on and off the power supply to control the progress of the ionization work.

In one implementation, a gap is left between the discharge electrode 102 and the needle tube 103 to form an open circuit, and the air in the gap is ionized to form a micro-arc plasma slot 104 .

In this embodiment, in order to facilitate the manipulation of the needle tip of the needle tube 103 for efficient ionization treatment, a number of micro-arc plasma slots 104 are arranged at equal intervals in the needle tube 103, and both sides of each micro-arc plasma slot 104 are filled with high-temperature resistant insulating coatings 105. The lines of the discharge electrode 102 pass through each micro-arc plasma slot 104. When the needle tube 103 intervenes in the tissue, the air in the slot can be ionized through the discharge electrode 102 in each micro-arc plasma slot 104, and the tissue can be treated with ionization in multiple stages and on a large scale.

In one implementation, the line center of the discharge electrode 102 and the center of the needle tube 103 are located on the same horizontal axis, and the outer surface of the discharge electrode 102 is evenly arranged in the space of the inner wall of the needle tube 103, so that the discharge electrode 102 evenly ionizes the gas in the surrounding space to avoid local unevenness that affects the control accuracy.

In the present application, after the needle tube 103 is inserted into human tissue, a power-adjustable switch 106 is used to ionize the air in the gap between the discharge electrode 102 and the stainless steel tube grounding electrode to form a micro-arc plasma discharge. The discharge electrode is in the middle of the needle tube 103, and multiple electrodes are arranged at equal intervals to form multiple micro-arc plasma slots 104. The power of the high-frequency and high-voltage power supply 100 is controlled by the power-adjustable switch 106, and then the discharge power is controlled, and the temperature of the discharge part of the needle tube is controlled. The needle tube 103 is inserted into human tissue. After the microneedle is inserted into the body, the temperature of the microneedle surface can be controlled by controlling the microplasma discharge current, thereby achieving the purpose of killing cancer cell tissue and ablating plaques.

It should be noted that, in this application, terms such as "comprises", "includes" or any other variations thereof are intended to cover non-exclusive inclusion, so that a device including a series of elements includes not only those elements, but also other elements not explicitly listed, or elements inherent to such an article or device. In the absence of more restrictions, an element defined by the sentence "comprises a ..." does not exclude the presence of other identical elements in the article or device including the element.

Each embodiment in the present application is described in a related manner, and the same or similar parts between the embodiments can be referred to each other, and each embodiment focuses on the differences from other embodiments. For related parts, refer to the partial description of the embodiment of the invasive heating microneedle described above.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims (10)

An interventional heating microneedle, characterized in that it comprises a needle tube (103) for inserting into human tissue, the needle tube (103) being used as a ground electrode via a connecting wire, a discharge electrode (102) being embedded in the inner wall of the needle tube (103) by filling and coating a high-temperature resistant insulating coating (105), the discharge electrode (102) and the needle tube (103) being respectively connected to a high-voltage electrode and a ground electrode of a high-frequency high-voltage power supply (100), and a gap being left between the discharge electrode (102) and the needle tube (103) to form an open circuit, and air in the gap being ionized to form a micro-arc plasma slot (104). The interventional heating microneedle according to claim 1 is characterized in that: the needle tube (103) is configured as a stainless steel tube, one end of which is configured as a conical structure, and the outer diameter of the needle tube (103) is configured to be less than 2 mm. The invasive heating microneedle according to claim 1 is characterized in that an insulating hand-held tube (101) is sleeved on one end of the needle tube (103) away from the cone head, and the insulating hand-held tube (101) is set to be a ceramic part or a plastic material part. The interventional heating microneedle according to claim 1 is characterized in that the discharge electrode (102) is configured as a metal part, and the metal part is a stainless steel part, an aluminum part or a copper part. The interventional heating microneedle according to claim 1 is characterized in that: the high-frequency and high-voltage power supply (100) is a power supply with a frequency range of 1 to 200 KHz. The interventional heating microneedle according to claim 5 is characterized in that: the high-frequency and high-voltage power supply (100) is provided with a power adjustable switch (106), and the power adjustable switch (106) is configured as a digital switch button. The interventional heating microneedle according to claim 1 is characterized in that the high temperature resistant insulating coating (105) is configured as a temperature resistant ceramic layer or a temperature resistant insulating paint layer. The interventional heating microneedle according to claim 1 is characterized in that: a space not filled with a high-temperature resistant insulating coating (105) is left at the conical head of the needle tube (103) to form a micro-arc plasma groove (104), and one end of the discharge electrode (102) protrudes into the micro-arc plasma groove (104). The interventional heating microneedle according to claim 1 is characterized in that: a plurality of micro-arc plasma slots (104) are arranged at equal intervals in the needle tube (103), both sides of each micro-arc plasma slot (104) are filled with a high-temperature resistant insulating coating (105) interval, and the line of the discharge electrode (102) passes through each micro-arc plasma slot (104). An interventional heating microneedle according to claim 8 or 9, characterized in that the line center of the discharge electrode (102) and the center of the heating needle tube (103) are located on the same horizontal axis.