WO2024033630A1

WO2024033630A1 - Aerosolisable material

Info

Publication number: WO2024033630A1
Application number: PCT/GB2023/052092
Authority: WO
Inventors: Nickolai SOLECHNIK; Ashley Micaela BICKERSTAFF; Alice HUGHES; Oriol STROPHAIR; Ashley Davies
Original assignee: Nicoventures Trading Ltd
Current assignee: Nicoventures Trading Ltd
Priority date: 2022-08-12
Filing date: 2023-08-08
Publication date: 2024-02-15
Anticipated expiration: 2025-02-12
Also published as: GB202211859D0; US20250287987A1; EP4568503A1; CA3264496A1

Abstract

There is provided an aerosolisable material comprising at least one carrier constituent comprising propylene glycol in an amount of at least 50%w/w based on the total weight of the aerosolisable material and a terpene block comprising four or more terpenes, wherein each terpene in the terpene block has a LogP of less than 6.4.

Description

Aerosolisable material

Field

The present disclosure relates to an aerosolisable material, a method of making said material, as well as containers and systems comprising and using said material.

Background

Aerosol delivery systems which generate an aerosol for inhalation by a user are known in the art. Such systems typically comprise an aerosol generator which is capable of converting an aerosolisable material into an aerosol. In some instances, the aerosol generated is a condensation aerosol whereby an aerosolisable material is heated to form a vapor which is then allowed to condense into an aerosol. In other instances, the aerosol generated is an aerosol which results from the atomization of the aerosolisable material. Such atomization may be brought about mechanically, e.g. by subjecting the aerosolisable material to vibrations so as to form small particles of material that are entrained in airflow. Alternatively, such atomization may be brought about electrostatically, or in other ways, such as by using pressure etc.

Depending on the constituents of the aerosolisable material that are to be provided to a user, it may be preferable to formulate the aerosolisable material in a certain way. For example, it may be preferable to formulate the aerosolisable material so as to produce an aerosol with a particular profile. It may also be preferable to formulate the aerosolisable material so as to ensure the aerosolisable material meets certain standards of quality, consistency and the like.

It would thus be desirable to provide an aerosolisable material that is formulated so as to be acceptable to a user.

Summary

In one aspect, there is provided an aerosolisable material comprising at least one carrier constituent comprising propylene glycol in an amount of at least 50%w/w based on the total weight of the aerosolisable material and a terpene block comprising four or more terpenes, wherein each terpene in the terpene block has a LogP of less than 6.4. In a further aspect there is provided an article comprising the aerosolisable material as defined herein.

In a further aspect there is provided an aerosol provision system comprising an aerosol provision device and an article as defined herein.

In a further aspect there is provided a method for producing the aerosolisable material as defined herein, the method comprising combining at least one carrier constituent comprising propylene glycol in an amount of at least 50%w/w based on the total weight of the aerosolisable material and a terpene block comprising four or more terpenes, wherein each terpene in the terpene block has a LogP of less than 6.4.

These aspects and other aspects will be apparent from the following detailed description. In this regard, particular sections of the description are not to be read in isolation from other sections.

Brief Description of the Drawings

Various embodiments will now be described in detail by way of example only with reference to the accompanying drawings in which:

Figure 1 - Provides a schematic overview of an article, aerosol delivery device and system as described herein.

Detailed Description

In one aspect, there is provided an aerosolisable material comprising at least one carrier constituent comprising propylene glycol in an amount of at least 50%w/w based on the total weight of the aerosolisable material and a terpene block comprising four or more terpenes, wherein each terpene in the terpene block has a LogP of less than 6.4.

A “terpene block” means a combination of multiple terpenes that are present in the aerosolisable material. Typically, the multiple terpenes are combined to form the “block” which is then added to the aerosolisable material.

LogP is the partition coefficient of a molecule between aqueous and lipophilic phases, usually considered as octanol and water. As referred to herein, the LogP of specific terpenes can be determined using the ”slow-stirring” method, wherein water, 1 -octanol and the test substance are equilibrated in a thermostated stirred reactor. Exchange between the phases is accelerated by stirring. The stirring introduces limited turbulence which enhances the exchange between 1 -octanol and water without microdroplets being formed. A suitable “slow-stirring” method is: Test No. 123: Partition Coefficient (1-Octanol/Water): Slow-Stirring Method, 30 June 2022, OECD Guidelines for the Testing of Chemicals.

Suitable terpenes for use in the aerosolisable material include so-called “C10” terpenes, which are those terpenes comprising 10 carbon atoms, and so-called “C15” terpenes, which are those terpenes comprising 15 carbon atoms.

In some embodiments, the aerosolisable material comprises more than four terpenes. For example, the aerosolisable material may comprise five, six, seven, eight, nine, ten or more terpenes as defined herein.

Each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 6.4. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 6.3. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 6.2. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 6.1. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 6.0. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 5.9. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 5.8. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 5.7. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 5.6. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 5.5. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 5.4. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 5.3. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 5.2. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 5.1. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 5.0. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 4.9. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 4.8. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 4.7. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 4.6. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of less than 4.5.

In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of from 2.0 to 6.4. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of from 2.0 to 6.0. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of from 2.0 to 5.5. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of from 2.0 to 5.0. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of from 2.0 to 4.5.

In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of from 2.5 to less than 6.4. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of from 3.0 to less than 6.4. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of from 3.0 to 6.0. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of from 3.0 to 5.5. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of from 3.0 to 5.0. In some embodiments, each of the terpenes in the terpene block of the aerosolisable material has a LogP of from 3.0 to 4.5.

In some embodiments, the terpenes in the terpene block are selected from the group consisting of alpha-humulene, valencene, nerolidol, alpha-bisabolol, guaiol, caryophyllene oxide, limonene, terpinolene, beta-myrcene, beta-ocimene, camphene, alpha-pinene, betapinene, linalyl acetate, geranyl acetate, beta-citronellol, linalool, alpha-terpineol, eucalyptol (1 ,8-cineole), fenchol and camphor, (-)- isopulegol, (-)-alpha-bisabolol, (-)-beta-pinene, (-)- caryophyllene oxide, (-)-guaiol, (-)-trans-caryophyllene, (+)-cedrol, (1R)-(+)-camphor, (S)-(-)- beta-citronellol, 3-carene, alpha-cedrene, alpha-phellandrene, alpha-terpinene, borneol, caryophyllene, cedrol, cisnerolidol, citronellol, cymene, fenchone, gamma-terpinene, geraniol, Isopulegol, L-(-)- fenchone, menthol, myrcene, nerol, nerolidol 1 , nerolidol 2, ocimene, ocimene 1, ocimene 2, p-cymene, pulegone, R-(+)-limonene, trans-nerolidol. In some embodiments, the terpenes in the terpene block are selected from the group consisting of alpha-humulene, valencene, nerolidol, alpha-bisabolol, guaiol, caryophyllene oxide, limonene, terpinolene, beta-myrcene, beta-ocimene, camphene, alpha-pinene, betapinene, linalyl acetate, geranyl acetate, beta-citronellol, linalool, alpha-terpineol, eucalyptol (1 ,8-cineole), fenchol and camphor. In some embodiments, In some embodiments, the terpenes in the terpene block are selected from the group consisting of limonene, terpinolene, beta-myrcene, beta-ocimene, camphene, alpha-pinene, beta-pinene, linalyl acetate, geranyl acetate, beta-citronellol, linalool, alpha-terpineol, eucalyptol (1,8-cineole), fenchol and camphor.

In some embodiments, the terpene block preferably comprises limonene, linalyl acetate, beta-citronellol and linalool.

In some embodiments, the terpene block is present in the aerosolisable material in an amount of at least 0.1%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 0.2%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 0.3%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 0.4%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 0.5%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 0.6%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 0.7%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 0.8%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 0.9%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 1.0%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 1.1%w/w based on the total weight of the aerosolisable material.

In one embodiment, the terpene block is present in the aerosolisable material in an amount of no greater than 5.0%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 4.5%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 4.0%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 3.5%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 3.0%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 2.5%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 2.0%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of at least 1 ,5%w/w based on the total weight of the aerosolisable material.

In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.1 to 5.0%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.1 to 4.5%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.1 to 4.0%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.1 to 3.5%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.1 to 3.0%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.1 to 2.5%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.1 to 2.0%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.1 to 1.5%w/w based on the total weight of the aerosolisable material.

In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.1 to 1.5%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.2 to 1.5%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.3 to 1.5%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.4 to 1.5%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.5 to 1.5%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.6 to 1 ,5%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.7 to 1.5%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.8 to 1.5%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 0.9 to 1.5%w/w based on the total weight of the aerosolisable material. In one embodiment, the terpene block is present in the aerosolisable material in an amount of from 1.0 to 1 ,5%w/w based on the total weight of the aerosolisable material.

In one embodiment, the total amount of terpene block present in the aerosolisable material is up to about 60 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is up to about 50 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is up to about 40 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is up to about 30 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is up to about 20 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is up to about 15 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is up to about 14 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is up to about 13 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is up to about 12 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is up to about 11 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is up to about 10 mg/ml.

In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 1 mg/ml up to about 60 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 5 mg/ml up to about 60 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 10 mg/ml up to about 60 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 12 mg/ml up to about 60 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 15 mg/ml up to about 60 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 20 mg/ml up to about 60 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 30 mg/ml up to about 60 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 40 mg/ml up to about 60 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 50 mg/ml up to about 60 mg/ml.

In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 1 mg/ml up to about 60 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 1 mg/ml up to about 50 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 1 mg/ml up to about 40 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 1 mg/ml up to about 30 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 1 mg/ml up to about 20 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 1 mg/ml up to about 15 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 1 mg/ml up to about 14 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 1 mg/ml up to about 13 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 1 mg/ml up to about 12 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 1 mg/ml up to about 11 mg/ml. In one embodiment, the total amount of terpene block present in the aerosolisable material is from about 1 mg/ml up to about 10 mg/ml.

For the avoidance of doubt, combinations of the above end points are explicitly envisaged by the present disclosure.

The carrier constituent comprises one or more constituents capable of forming an aerosol, particularly when evaporated and allowed to condense. The at least one carrier constituent comprises propylene glycol in an amount of at least 50%w/w based on the total weight of the aerosolisable material.

In one embodiment, propylene glycol is present in an amount of at least 55%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of at least 60%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of at least 65%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of at least 70%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of at least 75%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of at least 80%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of at least 85%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of at least 90%w/w based on the total weight of the material.

In one embodiment, propylene glycol is present in an amount of from 50%w/w to 95%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 55%w/w to 95%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 60%w/w to 95%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 65%w/w to 95%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 70%w/w to 95%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 75%w/w to 95%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 80%w/w to 95%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 85%w/w to 95%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 90%w/w to 95%w/w based on the total weight of the material.

In one embodiment, propylene glycol is present in an amount of from 50%w/w to 90%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 50%w/w to 85%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 50%w/w to 80%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 50%w/w to 75%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 50%w/w to 60%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 50%w/w to 65%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 50%w/w to 60%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 55%w/w to 90%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 60%w/w to 90%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 65%w/w to 90%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 70%w/w to 90%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 75%w/w to 90%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 80%w/w to 90%w/w based on the total weight of the material. In one embodiment, propylene glycol is present in an amount of from 85%w/w to 90%w/w based on the total weight of the material.

In one embodiment, propylene glycol is present in an amount of about 70%w/w based on the total weight of the material.

In some embodiments, the aerosolisable material comprises water in an amount of less than 12%w/w based on the total weight of the material. In some embodiments, the aerosolisable material comprises water in an amount of less than 11 %w/w based on the total weight of the material. In some embodiments, the aerosolisable material comprises water in an amount of less than 10%w/w based on the total weight of the material. In some embodiments, the aerosolisable material comprises water in an amount of less than 5%w/w based on the total weight of the material. In some embodiments, the aerosolisable material comprises water in an amount of less than 1%w/w based on the total weight of the material. In some embodiments, the aerosolisable material comprises water in an amount of less than 0.5%w/w based on the total weight of the material. In some embodiments, the aerosolisable material comprises substantially no water.

In some embodiments, the carrier constituent may further comprise one or more of glycerol, triethylene glycol, tetraethylene glycol, 1 ,3-butylene glycol, erythritol, meso-Erythritol, ethyl vanillate, ethyl laurate, a diethyl suberate, triethyl citrate, triethylene glycol diacetate, triacetin, a diacetin mixture, benzyl benzoate, benzyl phenyl acetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate.

In one embodiment, the carrier constituent further comprises glycerol.

In one embodiment, glycerol is present in an amount of from 1%w/w to 45%w/w based on the total weight of the material. In one embodiment, glycerol is present in an amount of from 10%w/w to 45%w/w based on the total weight of the material. In one embodiment, glycerol is present in an amount of from 20%w/w to 45%w/w based on the total weight of the material. In one embodiment, glycerol is present in an amount of from 30%w/w to 45%w/w based on the total weight of the material. In one embodiment, glycerol is present in an amount of from 40%w/w to 45%w/w based on the total weight of the material.

In one embodiment, glycerol is present in an amount of from 1%w/w to 40%w/w based on the total weight of the material. In one embodiment, glycerol is present in an amount of from 1%w/w to 35%w/w based on the total weight of the material. In one embodiment, glycerol is present in an amount of from 1 %w/w to 30%w/w based on the total weight of the material. In one embodiment, glycerol is present in an amount of from 1%w/w to 30%w/w based on the total weight of the material. In one embodiment, glycerol is present in an amount of from 1%w/w to 25%w/w based on the total weight of the material. In one embodiment, glycerol is present in an amount of from 1 %w/w to 20%w/w based on the total weight of the material. In one embodiment, glycerol is present in an amount of from 1%w/w to 15%w/w based on the total weight of the material.

In one embodiment, glycerol is present in an amount of at least 10%w/w based on the total weight of the material. In one embodiment, glycerol is present in an amount of at least 20%w/w based on the total weight of the material. In one embodiment, glycerol is present in an amount of at least 30%w/w based on the total weight of the material. In one embodiment, glycerol is present in an amount of at least 40%w/w based on the total weight of the material. In one embodiment, glycerol is present in an amount of at least 45%w/w based on the total weight of the material.

In one embodiment, both glycerol and propylene glycol are present as carrier constituents.

In one embodiment, glycerol and propylene glycol are present in the aerosolisable material in the following amounts:

60 to 90%w/w propylene glycol; and

40 to 10%w/w glycerol, based on the total weight of glycerol and propylene glycol present in the material.

70 to 80%w/w propylene glycol; and

30 to 20%w/w glycerol. based on the total weight of glycerol and propylene glycol present in the material.

In one embodiment, the aerosolisable material comprises about 70%w/w propylene glycol and about 30% glycerol based on the total weight of glycerol and propylene glycol present in the material.

In one embodiment, the aerosolisable material is a liquid at about 25°C.

In one embodiment, the aerosolisable material further comprises at least one cannabinoid as defined herein. Cannabinoids are a class of natural or synthetic chemical compounds which act on cannabinoid receptors (i.e. , CB1 and CB2) in cells that repress neurotransmitter release in the brain. Cannabinoids are cyclic molecules exhibiting particular properties such as the ability to easily cross the blood-brain barrier. Cannabinoids may be naturally occurring (Phytocannabinoids) from plants such as cannabis, (endocannabinoids) from animals, or artificially manufactured (synthetic cannabinoids). Cannabis species express at least 85 different phytocannabinoids, and these may be divided into subclasses, including cannabigerols, cannabichromenes, cannabidiols, tetrahydrocannabinols, cannabinols and cannabinodiols, and other cannabinoids.

According to one embodiment, the at least one cannabinoid may be selected from cannabigerol (CBG), cannabigerolic acid (CBGA), cannabichromene (CBC), cannabichromenic acid (CBCA), cannabidiol (CBD), cannabidolic acid (CBDA), tetrahydrocannabinol (THC), including its isomers A^6a’^10a-tetrahydrocannabinol (A^6a’^10a-THC), A^6a(7)-tetrahydrocannabinol (A^6a(7)-THC), A⁸-tetrahydrocannabinol (A⁸-THC), A⁹- tetrahydrocannabinol (A⁹-THC), A¹⁰-tetrahydrocannabinol (A¹⁰-THC), A^{9 11}- tetrahydrocannabinol (A^{9 11}-THC), tetrahydrocannabinolic acid (THCA), cannabinol (CBN), cannabinolic acid (CBNA), and cannabinodiol (CBDL), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM) and combinations thereof.

Naturally derived cannabinoids are generally present in their carboxylated form. In this regard, cannabidiol (CBD) and cannabidolic acid (CBDA) are the respective decarboxylated and carboxylated forms. CBD

CBDA

The cannabinoid referred to herein may be present in either the carboxylated or decarboxylated form. Exemplary carboxylated cannabinoid in this regard include cannabigerolic acid (CBGA), cannabichromenic acid (CBCA), cannabinolic acid (CBNA), tetrahydrocannabinolic acid (THCA), cannabidolic acid (CBDA) and combinations thereof.

In one embodiment, the cannabinoid is preferably cannabidiol (CBD) or a pharmaceutically acceptable salt thereof. In one embodiment, the cannabidiol is synthetic cannabidiol. In one embodiment, the cannabidiol is added to the aerosolisable material in the form of an isolate. An isolate is an extract from a plant, such as cannabis, where the active material of interest (in this case the cannabinoid, such as CBD) is present in a high degree of purity, for example greater than 95%, greater than 96%, greater than 97%, greater than 98%, or around 99% purity.

The cannabinoid may be present in the aerosolisable material based on a mg/ml basis of the aerosolisable material.

In one embodiment, the cannabinoid is present in an amount of from about 5 mg/ml up to about 200 mg/ml. In one embodiment, the cannabinoid is present in an amount of from about 5 mg/ml up to about 150 mg/ml. In one embodiment, the cannabinoid is present in an amount of from about 5 mg/ml up to about 120 mg/ml. In one embodiment, the cannabinoid is present in an amount of from about 5 mg/ml up to about 110 mg/ml. In one embodiment, the cannabinoid is present in an amount of from about 5 mg/ml up to about 100 mg/ml. In one embodiment, the cannabinoid is present in an amount of from about 5 mg/ml up to about 90 mg/ml. In one embodiment, the cannabinoid is present in an amount of from about 5 mg/ml up to about 80 mg/ml. In one embodiment, the cannabinoid is present in an amount of from about 5 mg/ml up to about 70 mg/ml. In one embodiment, the cannabinoid is present in an amount of from about 5 mg/ml up to about 60 mg/ml. In one embodiment, the cannabinoid is present in an amount of from about 5 mg/ml up to about 50 mg/ml. In one embodiment, the cannabinoid is present in an amount of from about 5 mg/ml up to about 40 mg/ml. In one embodiment, the cannabinoid is present in an amount of from about 5 mg/ml up to about 30 mg/ml. In one embodiment, the cannabinoid is present in an amount of from about 5 mg/ml up to about 20 mg/ml. In one embodiment, the cannabinoid is present in an amount of from about 5 mg/ml up to about 10 mg/ml.

In one embodiment, the cannabinoid is present in an amount of about 5 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 10 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 15 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 20 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 25 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 30 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 35 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 40 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 45 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 50 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 55 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 60 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 65 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 70 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 75 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 80 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 85 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 90 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 95 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 100 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 105 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 110 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 115 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 120 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 130 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 140 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 150 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 160 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 170 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 180 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 190 mg/ml or more. In one embodiment, the cannabinoid is present in an amount of about 200 mg/ml or more.

In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of at least 1%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of at least 2%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of at least 3%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of at least 4%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of at least 5%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of at least 6%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of at least 7%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of at least 8%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of at least 9%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of at least 10%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of at least 11%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of at least 12%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of at least 13%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of at least 14%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of at least 15%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of at least 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of no greater than 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of no greater than 19%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of no greater than 18%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of no greater than 17%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of no greater than 16%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of no greater than 15%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of no greater than 14%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of no greater than 13%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid

present in the aerosolisable material in an amount of no greater than 12%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of no greater than 11%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of no greater than 10%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of no greater than 9%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of no greater than 8%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of no greater than 7%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of no greater than 6%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of no greater than 5%w/w based on the total weight of the aerosolisable material.

In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 1 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 1 to 19%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 1 to 18%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 1 to 17%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 1 to 16%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 1 to 15%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 1 to 14%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 1 to 13%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 1 to 12%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 1 to 11%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 1 to 10%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 1 to 9%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 1 to 8%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 1 to 7%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 1 to 6%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 1 to 5%w/w based on the total weight of the aerosolisable material.

In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 2 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 3 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 4 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 5 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 6 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 7 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 8 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 9 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 10 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 11 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 12 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 13 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 14 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 15 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 16 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 17 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 18 to 20%w/w based on the total weight of the aerosolisable material. In one embodiment, the cannabinoid is present in the aerosolisable material in an amount of from 19 to 20%w/w based on the total weight of the aerosolisable material.

In one embodiment, the aerosolisable material comprises one or more stabilizing components. In one embodiment, the aerosolisable material comprises one or more stabilizing components when the aerosolisable material comprises a cannabinoid. In one embodiment, the aerosolisable material comprises one or more stabilizing components when the aerosolisable material comprises cannabidiol.

In one embodiment, the stabilising components are selected from antioxidants, pH modulators, chelators and radical scavengers, and combinations thereof.

In one embodiment, the one or more stabilizing components are selected from the class of compounds selected from enediols, pyrones, monoterpenoids, alpha-keto carboxylates, alpha-hydroxy carboxylic acids, esters, phenolic esters, flavonols o-glycosyls, and combinations thereof.

In one embodiment, the one or more stabilizing components are selected from the group consisting of ascorbic acid, sodium ascorbate, ethyl maltol, thymol, maltol, pyruvic acid, lactic acid, carvacrol, alpha-keto glutaric acid, alpha-keto glutarate salt, triethyl citrate, ethyl vanillate, quercetin, sucrose acetate isobutyrate, retinol, cholecalciferol, vitamin K- hydroquinone, citric acid, tartaric acid, ferulic acid, courmaric acid, propyl gallate, gallic acid, alpha lipoic acid, ascorbyl palmitate, lutein, lycopene, resveratrol, rutin, catechin, carnosol, rosmarinic acid, lipoic acid, a-resorcylic, pyrogallol, malvidin, theaflavin, apigenin, eriodictyol, glycitein, chrysoeriol, kaempferol, luteolin, vitexin, isovitexin, orientin, cannflavin A, cannflavin B, cannflavin C, delphinidin, pelargonidin, epicatechin, myricetin, chrysin, naringenin, a-terpineol, nerol, geranyl acetate, fenchol, propyl gallate, tertbutylhydroquinone, carvone and combinations thereof.

In one embodiment, the one or more stabilizing components are one or more antioxidants and one or more chelators.

In one embodiment, the one or more stabilizing components are one or more antioxidants.

The one or more antioxidants may be selected from the enediol class of compounds. For example, in one embodiment, the one or more antioxidants are selected from the group consisting of ascorbic acid, sodium ascorbate, retinol, cholecalciferol and combinations thereof.

In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants. In one embodiment, the one or more antioxidants comprise sodium ascorbate and one or more additional antioxidants. In one embodiment, the one or more antioxidants are ascorbic acid and/or sodium ascorbate. In one embodiment, the one or more antioxidants are ascorbic acid and sodium ascorbate. In one embodiment, the antioxidant is ascorbic acid. In one embodiment, the antioxidant is sodium ascorbate.

In one embodiment, the one or more stabilizing components are one or more chelators. In one embodiment, the one or more chelators are selected from the group consisting of ethyl maltol, maltol, and triethyl citrate. In one embodiment, the one or more stabilizing components are each present in an amount of at least 100ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 200ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 300ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 400ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 500ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 600ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 700ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 800ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 900ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least lOOOppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 1100ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 1200ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 1300ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 1400ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 1500ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 1600ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 1700ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 1800ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 1900ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 2000ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 2500ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 3000ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 3500ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 4000ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 4500ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 5000ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 6000ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 7000ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 8000ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 9000ppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least lOOOOppm. In one embodiment, the one or more stabilizing components are each present in an amount of at least 15000ppm.

In one embodiment, the one or more antioxidants are each present in an amount of at least 500ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 600ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 700ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 800ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 900ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least lOOOppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 1100ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 1200ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 1300ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 1400ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 1500ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 1600ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 1700ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 1800ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 1900ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 2000ppm.

In one embodiment, the one or more chelators are each present in an amount of at least 100ppm. In one embodiment, the one or more chelators are each present in an amount of at least 200ppm. In one embodiment, the one or more chelators are each present in an amount of at least 300ppm. In one embodiment, the one or more chelators are each present in an amount of at least 400ppm. In one embodiment, the one or more chelators are each present in an amount of at least 500ppm. In one embodiment, the one or more chelators are each present in an amount of at least 6000ppm. In one embodiment, the one or more chelators are each present in an amount of at least 700ppm. In one embodiment, the one or more chelators are each present in an amount of at least 800ppm. In one embodiment, the one or more chelators are each present in an amount of at least 900ppm. In one embodiment, the one or more chelators are each present in an amount of at least lOOOppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 500ppm and the one or more chelators are each present in an amount of at least 100ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 1000ppm and the one or more chelators are each present in an amount of at least 100ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 1500ppm and the one or more chelators are each present in an amount of at least 100ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 2000ppm and the one or more chelators are each present in an amount of at least 100ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 500ppm and the one or more chelators are each present in an amount of at least 500ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 1000ppm and the one or more chelators are each present in an amount of at least 500ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 1500ppm and the one or more chelators are each present in an amount of at least 500ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 2000ppm and the one or more chelators are each present in an amount of at least 500ppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 500ppm and the one or more chelators are each present in an amount of at least lOOOppm. In one embodiment, the one or more antioxidants are each present in an amount of at least lOOOppm and the one or more chelators are each present in an amount of at least lOOOppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 1500ppm and the one or more chelators are each present in an amount of at least lOOOppm. In one embodiment, the one or more antioxidants are each present in an amount of at least 2000ppm and the one or more chelators are each present in an amount of at least lOOOppm.

In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants, wherein ascorbic acid is present in an amount of at least 400ppm. In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants, wherein ascorbic acid is present in an amount of at least 500ppm. In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants, wherein ascorbic acid is present in an amount of at least 750ppm. In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants, wherein ascorbic acid is present in an amount of at least lOOOppm. In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants, wherein ascorbic acid is present in an amount of at least 1250ppm. In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants, wherein ascorbic acid is present in an amount of at least 1500ppm. In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants, wherein ascorbic acid is present in an amount of at least 1750ppm. In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants, wherein ascorbic acid is present in an amount of at least 2000ppm. In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants, wherein ascorbic acid is present in an amount of at least 2500ppm. In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants, wherein ascorbic acid is present in an amount of at least 3000ppm. In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants, wherein ascorbic acid is present in an amount of at least 3500ppm. In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants, wherein ascorbic acid is present in an amount of at least 4000ppm. In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants, wherein ascorbic acid is present in an amount of at least 4500ppm. In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants, wherein ascorbic acid is present in an amount of at least 5000ppm. In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants, wherein ascorbic acid is present in an amount of at least 6000ppm. In one embodiment, the one or more antioxidants comprise ascorbic acid and one or more additional antioxidants, wherein ascorbic acid is present in an amount of at least 7000ppm.

In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 500ppm and sodium ascorbate is present in an amount of at least 500ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 750ppm and sodium ascorbate is present in an amount of at least 500ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 1000ppm and sodium ascorbate is present in an amount of at least 500ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 1250ppm and sodium ascorbate is present in an amount of at least 500ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 1500ppm and sodium ascorbate is present in an amount of at least 500ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 1750ppm and sodium ascorbate is present in an amount of at least 500ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 2000ppm and sodium ascorbate is present in an amount of at least 500ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 500ppm and sodium ascorbate is present in an amount of at least 750ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 750ppm and sodium ascorbate is present in an amount of at least 750ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 1000ppm and sodium ascorbate is present in an amount of at least 750ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 1250ppm and sodium ascorbate is present in an amount of at least 750ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 1500ppm and sodium ascorbate is present in an amount of at least 750ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 1750ppm and sodium ascorbate is present in an amount of at least 750ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 2000ppm and sodium ascorbate is present in an amount of at least 750ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 1000ppm and sodium ascorbate is present in an amount of at least lOOOppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 1250ppm and sodium ascorbate is present in an amount of at least lOOOppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 1500ppm and sodium ascorbate is present in an amount of at least lOOOppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 1750ppm and sodium ascorbate is present in an amount of at least lOOOppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 2000ppm and sodium ascorbate is present in an amount of at least lOOOppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least lOOOppm and sodium ascorbate is present in an amount of at least 2000ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 2000ppm and sodium ascorbate is present in an amount of at least 2000ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 3000ppm and sodium ascorbate is present in an amount of at least 2000ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 4000ppm and sodium ascorbate is present in an amount of at least 2000ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 1000ppm and sodium ascorbate is present in an amount of at least 3000ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 2000ppm and sodium ascorbate is present in an amount of at least 3000ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 3000ppm and sodium ascorbate is present in an amount of at least 3000ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 4000ppm and sodium ascorbate is present in an amount of at least 3000ppm.ln one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 1000ppm and sodium ascorbate is present in an amount of at least 4000ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 2000ppm and sodium ascorbate is present in an amount of at least 4000ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 3000ppm and sodium ascorbate is present in an amount of at least 4000ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of at least 4000ppm and sodium ascorbate is present in an amount of at least 4000ppm.

In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 500 to 4000ppm and sodium ascorbate is present in an amount of from 500 to 4000ppm.ln one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 500 to 4000ppm and sodium ascorbate is present in an amount of from 1000 to 3000ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 500 to 4000ppm and sodium ascorbate is present in an amount of from 1000 to 2000ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 1000 to 3000ppm and sodium ascorbate is present in an amount of from 500 to 4000ppm.ln one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 100 to 2000ppm and sodium ascorbate is present in an amount of from 500 to 4000ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 1000 to 4000ppm and sodium ascorbate is present in an amount of from 1000 to 4000ppm.ln one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 1000 to 3000ppm and sodium ascorbate is present in an amount of from 1000 to 3000ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 1000 to 2000ppm and sodium ascorbate is present in an amount of from 1000 to 2000ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 1000 to 2000ppm and sodium ascorbate is present in an amount of from 500 to lOOOppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 1000 to 1750ppm and sodium ascorbate is present in an amount of from 500 to lOOOppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 1000 to 1500ppm and sodium ascorbate is present in an amount of from 500 to lOOOppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 1000 to 1250ppm and sodium ascorbate is present in an amount of from 500 to lOOOppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 1000 to 2000ppm and sodium ascorbate is present in an amount of from 750 to lOOOppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 1000 to 1750ppm and sodium ascorbate is present in an amount of from 750 to lOOOppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 1000 to 1500ppm and sodium ascorbate is present in an amount of from 750 to lOOOppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 1000 to 1250ppm and sodium ascorbate is present in an amount of from 750 to lOOOppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 750 to 2000ppm and sodium ascorbate is present in an amount of from 750 to 1250ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 750 to 1750ppm and sodium ascorbate is present in an amount of from 750 to 1250ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 750 to 1500ppm and sodium ascorbate is present in an amount of from 750 to 1250ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 750 to 1250ppm and sodium ascorbate is present in an amount of from 750 to 1250ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 750 to 1250ppm and sodium ascorbate is present in an amount of from 750 to 2000ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 750 to 1250ppm and sodium ascorbate is present in an amount of from 750 to 1750ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of from 750 to 1250ppm and sodium ascorbate is present in an amount of from 750 to 1500ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of about 1250ppm and sodium ascorbate is present in an amount of about 750ppm. In one embodiment, the antioxidants are ascorbic acid and sodium ascorbate, wherein ascorbic acid is present in an amount of about 1000ppm and sodium ascorbate is present in an amount of about lOOOppm.

In one embodiment, the one or more stabilizing components are present in an amount of from 0.05%w/w to 10%w/w based on the total weight of the aerosolisable material. In one embodiment, the one or more stabilizing components are present in an amount of from 0.05%w/w to 9%w/w based on the total weight of the aerosolisable material. In one embodiment, the one or more stabilizing components are present in an amount of from 0.05%w/w to 8%w/w based on the total weight of the aerosolisable material. In one embodiment, the one or more stabilizing components are present in an amount of from 0.05%w/w to 7%w/w based on the total weight of the aerosolisable material. In one embodiment, the one or more stabilizing components are present in an amount of from 0.05%w/w to 6%w/w based on the total weight of the aerosolisable material. In one embodiment, the one or more stabilizing components are present in an amount of from 0.05%w/w to 5%w/w based on the total weight of the aerosolisable material. In one embodiment, the one or more stabilizing components are present in an amount of from 0.05%w/w to 4%w/w based on the total weight of the aerosolisable material. In one embodiment, the one or more stabilizing components are present in an amount of from 0.05%w/w to 3%w/w based on the total weight of the aerosolisable material. In one embodiment, the one or more stabilizing components are present in an amount of from 0.05%w/w to 2%w/w based on the total weight of the aerosolisable material. In one embodiment, the one or more stabilizing components are present in an amount of from 0.05%w/w to 1%w/w based on the total weight of the aerosolisable material. In one embodiment, the one or more stabilizing components are present in an amount of from 0.05%w/w to 0.5%w/w based on the total weight of the aerosolisable material. In one embodiment, the one or more stabilizing components are present in an amount of from 0.05%w/w to 0.4%w/w based on the total weight of the aerosolisable material. In one embodiment, the one or more stabilizing components are present in an amount of from

0.05%w/w to 0.3%w/w based on the total weight of the aerosolisable material. In one embodiment, the one or more stabilizing components are present in an amount of from

0.05%w/w to 0.2%w/w based on the total weight of the aerosolisable material. In one embodiment, the one or more stabilizing components are present in an amount of from

0.05%w/w to 0.15%w/w based on the total weight of the aerosolisable material. In one embodiment, the one or more stabilizing components are present in an amount of from

0.1%w/w to 0.15%w/w based on the total weight of the aerosolisable material. In one embodiment, the one or more stabilizing components are present in an amount of about 0.12%w/w based on the total weight of the aerosolisable material.

The aerosolisable material may comprise one or more further constituents. In particular, one or more further constituents may be selected from one or more physiologically and/or olfactory active constituents, and/or one or more functional constituents.

In some embodiments, the active constituent is a physiologically active constituent and may be selected from nicotine, nicotine salts (e.g. nicotine ditartrate/ni cotine bitartrate), nicotine- free tobacco substitutes, other alkaloids such as caffeine, or mixtures thereof.

In some embodiments, the active constituent is an olfactory active constituent and may be selected from a "flavour" and/or "flavourant" which, where local regulations permit, may be used to create a desired taste, aroma or sensation in a product for adult consumers. In some instances such constituents may be referred to as flavours, flavourants, cooling agents, heating agents, or sweetening agents, and may include one or more of extracts (e.g., licorice, hydrangea, Japanese white bark magnolia leaf, chamomile, fenugreek, clove, menthol, Japanese mint, aniseed, cinnamon, herb, Wintergreen, cherry, berry, peach, apple, Drambuie, bourbon, scotch, whiskey, spearmint, peppermint, lavender, cardamom, celery, cascarilla, nutmeg, sandalwood, bergamot, geranium, honey essence, rose oil, vanilla, lemon oil, orange oil, cassia, caraway, cognac, jasmine, ylang-ylang, sage, fennel, piment, ginger, anise, coriander, coffee, or a mint oil from any species of the genus Mentha), flavour enhancers, bitterness receptor site blockers, sensorial receptor site activators or stimulators, sugars and/or sugar substitutes (e.g., sucralose, acesulfame potassium, aspartame, saccharine, cyclamates, lactose, sucrose, glucose, fructose, sorbitol, or mannitol), and other additives such as charcoal, chlorophyll, minerals, botanicals, or breath freshening agents. They may be imitation, synthetic or natural ingredients or blends thereof. They may be in any suitable form, for example, oil, liquid, or powder. The flavor may be added to the aerosolisable material as part of a so-called “flavour block”, where one or more flavours are blended together and then added to the aerosolisable material.

In one embodiment, the terpene(s) are present in a flavour block. This means that the terpenes are blended with one or more other flavours (optionally with an appropriate solvent, for example propylene glycol) and then the flavour block is added during the manufacture of the aerosolisable material. In some embodiments, the total amount of the flavour block present in the aerosolisable material is up to about 30 w/w%. In some embodiments, the total amount of the flavour block present in the aerosolisable material is up to about 25 w/w%. In some embodiments, the total amount of the flavour block present in the aerosolisable material is up to about 20 w/w%. In some embodiments, the total amount of the flavour block present in the aerosolisable material is up to about 15 w/w%. In some embodiments, the total amount of the flavour block present in the aerosolisable material is up to about 10 w/w%. In some embodiments, the total amount of the flavour block present in the aerosolisable material is up to about 9 w/w%. In some embodiments, the total amount of the flavour block present in the aerosolisable material is up to about 8 w/w%. In some embodiments, the total amount of the flavour block present in the aerosolisable material is up to about 7 w/w%. In some embodiments, the total amount of the flavour block present in the aerosolisable material is up to about 6 w/w%. In some embodiments, the total amount of the flavour block present in the aerosolisable material is up to about 5 w/w%.

The one or more other functional constituents may comprise one or more of pH regulators, colouring agents, preservatives, binders, fillers, stabilizers, and/or antioxidants. In particular, the pH regulator may include one or more acids selected from organic or inorganic acids. An example of an inorganic acid is phosphoric acid. The organic acid may be include a carboxylic acid. The carboxylic acid may be any suitable carboxylic acid. In one embodiment the acid is a mono-carboxylic acid. In one embodiment the acid may be selected from the group consisting of ascorbic acid, acetic acid, lactic acid, formic acid, citric acid, benzoic acid, pyruvic acid, levulinic acid, succinic acid, tartaric acid, oleic acid, sorbic acid, propionic acid, phenylacetic acid, and mixtures thereof.

In some embodiments, an acceptable turbidity is achieved without the use of functional constituents which influence the stability of the aerosolisable material. For example, it may be possible to decrease the turbidity of a liquid system by introducing surface active constituents which serve to improve the emulsification/dispersion of one or more of the constituents. However, it may not be desirable to include such functional constituents due to user acceptability. Therefore, in some embodiments, the aerosolisable material does not comprise a surface active constituent. Examples of surface active constituents include medium chain triglycerides (MCT) and tocopherol acetate.

In some embodiments, an acceptable turbidity is achieved without the use of any/significant amounts of water. In this regard, whilst water may otherwise assist in the preparation of aerosolisable materials since water containing materials may have a lower viscosity and therefore may be transferred more easily to an aerosol generating component, it has been found in the context of the present disclosure that water can negatively influence the stability of the aerosolisable material containing at least one cannabinoid.

In a further aspect there is provided an article comprising the aerosolisable material as defined herein.

The article may be a container, such as a bottle, or may be a component for use with an aerosol provision device.

For example, the article may comprise an area (store) for receiving the aerosolisable material defined herein, an aerosol generating component, an aerosol generating area, and/or a mouthpiece.

In some embodiments, there is provided an article for use with an aerosol provision system, the article comprising a store comprising an aerosolisable material as defined herein, an aerosol generating component (such as a heater), an aerosol generating area, a transport element, and a mouthpiece.

Aerosolisable material may be transferred from the store for receiving an aerosolisable material to the aerosol generating component via a transport element, such as a wick, pump or the like. The skilled person is able to select suitable transport elements depending on the type of aerosolisable material that is to be transported and the rate at which it must be supplied. Particular mention may be made of transport elements, such as wicks, formed from fibrous materials, foamed materials, sintered materials, woven and non-woven materials.

An airflow pathway typically extends through the article (optionally via the device) to an outlet. The pathway is oriented such that generated aerosol is entrained in the airflow such that it can be delivered to the outlet for inhalation by a user. In one embodiment, the aerosol generating component is a heater.

Typically, the area for receiving an aerosolisable material will allow for the article to be refilled with aerosolisable material as the aerosolisable material is depleted during use.

Figure 1 is a highly schematic diagram (not to scale) of an example aerosol provision system, such as an e-cigarette 10, to which embodiments are applicable. The e-cigarette has a generally cylindrical shape, extending along a longitudinal axis indicated by a dashed line (although aspects of the invention are applicable to e-cigarettes configured in other shapes and arrangements), and comprises two main components, namely an aerosol provision device 20 and an article 30.

The article 30 includes a store for aerosolisable material (source liquid) 38 containing an aerosolisable material (source liquid) from which an aerosol is to be generated. The article 30 further comprises an aerosol generating component (heating element or heater) 36 for heating aerosolisable material to generate the aerosol. A transport element or wicking element or wick 37 is provided to deliver aerosolisable material from the store 38 to the heating element 36. A part or parts of the wick 37 are in fluid communication with aerosolisable material in the store 38 and by a wicking or capillary action aerosolisable material is drawn along or through the wick 37 to a part or parts of the wick 37 which are in contact with the heater 36.

Vaporization of the aerosolisable material occurs at the interface between the wick 37 and the heater 36 by the provision of heat energy to the aerosolisable material to cause evaporation, thus generating the aerosol. The aerosolisable material, the wick 37 and the heater 36 may be collectively referred to as an aerosol or vapour source. The wick 37 and the heater 36 may be collectively referred to as a vaporizer or an atomiser 15.

Typically a single wick will be present, but it is envisaged that more than one wick could be present, for example, two, three, four or five wicks.

As described above, the wick may be formed a sintered material. The sintered material may comprise sintered ceramic, sintered metal fibers/powders, or a combination of the two. The (or at least one of/all of the) sintered wick(s) may have deposited thereon/embedded therein an electrically resistive heater. Such a heater may be formed from heat conducting alloys such as NiCr alloys. Alternatively, the sintered material may have such electrical properties such that when a current is passed there through, it is heated. Thus, the aerosol generating component and the wick may be considered to be integrated. In some embodiments, the aerosol generating component and the wick are formed from the same material and form a single component.

In some embodiments, the wick is formed from a sintered metal material and is generally in the form of a planar sheet. Thus, the wick element may have a substantially thin flat shape. For example it may be considered as a sheet, layer, film, substrate or the like. By this it is meant that a thickness of the wick is less or very much less than at least one of the length and the width of the wick. Thus, the wick thickness (its smallest dimension) is less or very much less than the longest dimension.

The wick may be made of a homogenous, granular, fibrous or flocculent sintered metal(s) so as to form said capillary structure. Wick elements can be made from a conductive material which is a nonwoven sintered porous web structure comprising metal fibres, such as fibres of stainless steel. For example, the stainless steel may be AISI (American Iron and Steel Institute) 316L (corresponding to European standard 1.4404). The material’s weight may be in the range of 100 - 300 g/m².

Where the wick is generally planar, the thickness of the wick may be in the range of 75 - 250 pm. A typical fibre diameter may be about 12 pm, and a typical mean pore size (size of the voids between the fibres) may be about 32 pm. An example of a material of this type is Bekipor (RTM) ST porous metal fibre media manufactured by NV Bekaert SA, Belgium, being a range of porous nonwoven fibre matrix materials made by sintering stainless steel fibres.

Note also that while the material is described as planar, this refers to the relative dimensions of the sheet material and the wick (a thickness many times smaller than the length and/or width) but does not necessarily indicate flatness, in particular of the final wick made from the material. A wick may be flat but might alternatively be formed from sheet material into a nonflat shape such as curved, rippled, corrugated, ridged, formed into a tube or otherwise made concave and/or convex.

The wick element may have various properties. It is formed from a porous material to enable the required wicking or capillary effect for drawing source liquid through it from an store for aerosolisable material (where the wick meets the aerosolisable material at a store contact site) to the vaporisation interface. Porosity is typically provided by a plurality of interconnected or partially interconnected pores (holes or interstices) throughout the material, and open to the outer surface of the material. Any level of porosity may be employed depending on the material, the size of the pores and the required rate of wicking. For example a porosity of between 30% and 85% might be selected, such as between 40% and 70%, between 50% and 80%, between 35% and 75% or between 40% and 75%. This might be an average porosity value for the whole wick element, since porosity may or may not be uniform across the wick. For example, pore size at the store contact site might be different from pore size nearer to the heater.

It is useful for the wick to have sufficient rigidity to support itself in a required within the article. For example, it may be mounted at or near one or two edges and be required to maintain its position substantially without flexing, bending or sagging.

As an example, porous sintered ceramic is a useful material to use as the wick element. Any ceramic with appropriate porosity may be used. If porous ceramic is chosen as the porous wick material, this is available as a powder which can be formed into a solid by sintering (heating to cause coalescence, possibly under applied pressure). Sintering then solidifies the ceramic to create the porous wick.

The article 30 further includes a mouthpiece 35 having an opening through which a user may inhale the aerosol generated by the vaporizer 15. The aerosol for inhalation may be described as an aerosol stream or inhalable airstream.

The aerosol delivery device 20 includes a power source (a re-chargeable cell or battery 14, referred to herein after as a battery) to provide power for the e-cigarette 10, and a controller (printed circuit board (PCB)) 28 and/or other electronics for generally controlling the e- cigarette 10. The aerosol delivery device can therefore also be considered as a battery section, or a control unit or section.

During operation of the device, the controller will determine that a user has initiated a request for the generation of an aerosol. This could be done via a button on the device which sends a signal to the controller that the aerosol generator should be powered. Alternatively, a sensor located in or proximal to the airflow pathway could detect airflow through the airflow pathway and convey this detection to the controller. A sensor may also be present in addition to the presence of a button, as the sensor may be used to determine certain usage characteristics, such as airflow, timing of aerosol generation etc. For example, in use, when the heater 36 receives power from the battery 14, as controlled by the circuit board 28 possibly in response to pressure changes detected by an air pressure sensor (not shown), the heater 36 vaporizes aerosolisable material delivered by the wick 37 to generate the aerosol, and this aerosol stream is then inhaled by a user through the opening in the mouthpiece 35. The aerosol is carried from the aerosol source to the mouthpiece 35 along an air channel (not shown in Figure 1) that connects the aerosol source to the mouthpiece opening as a user inhales on the mouthpiece.

In this particular example, the device 20 and article 30 are detachable from one another by separation in a direction parallel to the longitudinal axis, as shown in Figure 1 , but are joined together when the system 10 is in use by cooperating engagement elements 21 , 31 (for example, a screw, magnetic or bayonet fitting) to provide mechanical and electrical connectivity between the device 20 and the article 30, in particular connecting the heater 36 to the battery 14. The battery may be charged as is known to one skilled in the art.

In some embodiments, the article comprises/forms a sealed container. For example, the sealed container may be hermetically sealed. The inclusion of the aerosolisable material in a sealed article assists in preventing water ingress into the system, which can prevent the cannabidiol from precipitating. The hermetically sealed container may comprise a blister pack with one or more hermetically sealed compartments for storage of one or more articles comprising the aerosolisable material described herein.

In some embodiments, the article comprises a housing within which the aerosolisable material is contained. The housing may be transparent such that the aerosolisable material can be viewed from outside of the housing. It may also be that the housing has a degree of opacity such that the passage of light through the housing is limited. This can be important so as to prevent light (such as ultra violet light) from entering the housing and compromising the stability of the aerosolisable material. In this regard, the present inventors have considered that cannabinoids may be particularly susceptible to such light destabilization. In some embodiments, the housing is formed from a material which inhibits/prevents the passage of ultra violet light there through. In some embodiments, it may be that the sealed container mentioned above is formed from a material which has a degree of opacity such that the passage of light through the sealed container is limited. Further, the sealed container mentioned above may be formed from a material which inhibits/prevents the passage of ultra violet light there through. This may be in addition to said sealed container being hermetically sealed and/or comprising a blister pack with one or more hermetically sealed compartments for storage of one or more articles comprising the aerosolisable material described herein.

In some embodiments, the terpene block is prepared by combining the multiple terpenes together before being added to the other constituents of the aerosolisable material.

In some embodiments, the method excludes a step of adding water to the aerosolisable material.

In a further aspect, there is provided a method for producing an aerosol comprising generating an aerosol from an aerosolisable material as defined herein.

Examples

Various terpene blocks (N1 - N4) were prepared as shown in Table 1.

Table 1

As shown in Table 1, terpene blocks N1 - N3 comprise Beta caryophyllene, limonone, linalool, llinalyl acetate and beta-cintronellol, whilst terpene block N4 only comprises limonone, linalool, llinalyl acetate and beta-cintronellol. The LogP values for the terpenes used in terpene blocks N1 - N4 are provided in Table 2 below.

Table 2

The solubility of terpene blocks N1 - N4 at various concentrations was then investigated in propylene glycol and 70:30 propylene glycokglycerol. The results of these investigations are shown below in Table 3.

Table 3

As can be seen from Table 3, terpene block N4 comprising four terpenes with LogPs of less than 6.4 was found to be soluble at 1.4% in propylene glycol and at 1%, 1.5% and 2% in 70:30 propylene glycokglycerol.

On the other hand, terpene block N2 comprising 50wt.% beta-caryophyllene (a terpene having a LogP greater than 6.4), was found to be insoluble at all concentrations tested in propylene glycol and 70:30 propylene glycokglycerol. Moreover, terpene blocks N1 and N3 (comprising 20wt.% beta-caryophyllene) were found to be insoluble at 1.5% in 70:30 propylene glycokglycerol.

This data thus demonstrates that terpene blocks comprising four or more terpenes, wherein each terpene of the terpene block has a LogP less than 6.4, show enhanced solubility in carrier constituents comprising propylene glycol.

The present invention is further described in the following clauses:

1. An aerosolisable material comprising at least one carrier constituent comprising propylene glycol in an amount of at least 50%w/w based on the total weight of the aerosolisable material and a terpene block comprising four or more terpenes, wherein each terpene in the terpene block has a LogP of less than 6.4.

2. The aerosolisable material according to clause 1 , wherein each terpene in the terpene block has a LogP of less than 5.5.

3. The aerosolisable material according to clause 1 or 2, wherein each terpene in the terpene block has a LogP of less than 4.5.

4. The aerosolisable material according to clause 1, wherein each terpene in the terpene block is selected from the group consisting of alpha-humulene, valencene, nerolidol, alpha-bisabolol, guaiol, caryophyllene oxide, limonene, terpinolene, beta-myrcene, beta- ocimene, camphene, alpha-pinene, beta-pinene, linalyl acetate, geranyl acetate, betacitronellol, linalool, alpha-terpineol, eucalyptol (1,8-cineole), fenchol and camphor.

5. The aerosolisable material according to clause 4, wherein each terpene in the terpene block is selected from the group consisting of limonene, terpinolene, beta-myrcene, beta-ocimene, camphene, alpha-pinene, beta-pinene, linalyl acetate, geranyl acetate, betacitronellol, linalool, alpha-terpineol, eucalyptol (1,8-cineole), fenchol and camphor.

6. The aerosolisable material according to any proceeding clause, wherein the terpene block comprises limonene, linalyl acetate, beta-citronellol and linalool.

7. The aerosolisable material according to any proceeding clause, wherein the propylene glycol is present in an amount of at least 60%w/w based on the total weight of the aerosolisable material. 8. The aerosolisable material according to clause 7, wherein the propylene glycol is present in an amount of at least 70%w/w based on the total weight of the aerosolisable material.

9. The aerosolisable material according to any one of the preceding clauses, wherein the carrier constituent further comprises one or more of glycerol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, erythritol, meso-Erythritol, ethyl vanillate, ethyl laurate, a diethyl suberate, triethyl citrate, triethylene glycol diacetate, triacetin, a diacetin mixture, benzyl benzoate, benzyl phenyl acetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate.

10. The aerosolisable material according to clause 9, wherein the carrier constituent further comprises glycerol.

11. The aerosolisable material according to clause 10, wherein glycerol is present in an amount of at least 20%w/w based on the total weight of the aerosolisable material.

12. The aerosolisable material according to clause 10 or 11 , wherein glycerol is present in an amount of at least 30%w/w based on the total weight of the aerosolisable material.

13. The aerosolisable material according to any one of clauses 10 to 12, wherein, based on the total amount of propylene glycol and glycerol in the aerosolisable material, the aerosolisable material comprises:

60 to 90%w/w propylene glycol; and

40 to 10%w/w glycerol.

14. The aerosolisable material according to clause 13, wherein, based on the total amount of propylene glycol and glycerol in the aerosolisable material, the aerosolisable material comprises:

70 to 80%w/w propylene glycol; and

30 to 20%w/w glycerol.

15. The aerosolisable material according to clause 13, wherein, based on the total amount of propylene glycol and glycerol in the aerosolisable material, the aerosolisable material comprises about 70%w/w propylene glycol and about 30% glycerol. 16. The aerosolisable material according to any one of the preceding clauses, wherein the aerosolisable material further comprises at least one cannabinoid.

17. The aerosolisable material according to clause 16, wherein the cannabinoid is cannabidiol.

18. The aerosolisable material according to clause 16 or clause 17, wherein the cannabinoid is present in the aerosolisable material in an amount of 10mg/ml of material or more.

19. The aerosolisable material according to clause 18, wherein the cannabinoid is present in the aerosolisable material in an amount of 30mg/ml of material or more.

20. The aerosolisable material according to clause 18, wherein the cannabinoid is present in the aerosolisable material in an amount of 60mg/ml of material or more.

21. The aerosolisable material according to clause 16 or clause 17, wherein the cannabinoid is present in the aerosolisable material in an amount of at least 1%w/w based on the total weight of the aerosolisable material.

22. The aerosolisable material according to clause 21, wherein the cannabinoid is present in the aerosolisable material in an amount of at least 2.5%w/w based on the total weight of the aerosolisable material.

23. The aerosolisable material according to clause 21, wherein the cannabinoid is present in the aerosolisable material in an amount of at least 5%w/w based on the total weight of the aerosolisable material.

24. The aerosolisable material according to any one of the preceding clauses, wherein the terpene block is present in the aerosolisable material in an amount of at least 0.5%w/w based on the total weight of the aerosolisable material.

25. The aerosolisable material according to clause 24, wherein the terpene block is present in the aerosolisable material in an amount of at least 1%w/w based on the total weight of the aerosolisable material. 26. The aerosolisable material according to any one of the preceding clauses, wherein the aerosolisable material further comprises one or more active constituents in addition to the cannabinoid.

27. The aerosolisable material according to clause 26, wherein the one or more active constituents is an olfactory active constituent.

28. The aerosolisable material according to any one of the preceding clauses, wherein the aerosolisable material does not comprise a surface active constituent.

29. An article comprising the aerosolisable material as defined in any one of clauses 1 to 28.

30. The article according to clause 29, the article comprising a store for receiving the aerosolisable material of any one of clauses 1 to 28, an aerosol generating component, an aerosol generating area, a transport element and a mouthpiece.

31. The article according to clause 30, wherein the aerosol generating component comprises a heater.

32. The article according to clause 30 or clause 31 , wherein the transport element is a wick.

33. An aerosol provision system comprising an aerosol provision device and an article as defined in any one of clauses 29 to 32.

34. A method for producing the aerosolisable material as defined herein, the method comprising combining at least one carrier constituent comprising propylene glycol in an amount of at least 50%w/w based on the total weight of the aerosolisable material and a terpene block comprising four or more terpenes, wherein each terpene in the terpene block has a LogP of less than 6.4.

35. The method according to clause 34, the method being characterized according to the features of any one of clauses 2 to 28.

36. A sealed container comprising the article according to any one of clauses 29 to 32. 37. The sealed container according to clause 36, wherein the container is hermetically sealed and is formed from a material which inhibits/prevents the passage of ultra violet light there through.

38. The sealed container according to clause 36 or clause 37, the sealed container comprising a blister pack with one or more hermetically sealed compartments.

The various embodiments described herein are presented only to assist in understanding and teaching the claimed features. These embodiments are provided as a representative sample of embodiments only, and are not exhaustive and/or exclusive. It is to be understood that advantages, embodiments, examples, functions, features, structures, and/or other aspects described herein are not to be considered limitations on the scope of the invention as defined by the claims or limitations on equivalents to the claims, and that other embodiments may be utilised and modifications may be made without departing from the scope of the claimed invention. Various embodiments of the invention may suitably comprise, consist of, or consist essentially of, appropriate combinations of the disclosed elements, components, features, parts, steps, means, etc., other than those specifically described herein. In addition, this disclosure may include other inventions not presently claimed, but which may be claimed in future.

Claims

2. The aerosolisable material according to claim 1, wherein each terpene in the terpene block has a LogP of less than 5.5.

3. The aerosolisable material according to claim 1 or 2, wherein each terpene in the terpene block has a LogP of less than 4.5.

4. The aerosolisable material according to claim 1 , wherein each terpene in the terpene block is selected from the group consisting of alpha-humulene, valencene, nerolidol, alpha- bisabolol, guaiol, caryophyllene oxide, limonene, terpinolene, beta-myrcene, beta-ocimene, camphene, alpha-pinene, beta-pinene, linalyl acetate, geranyl acetate, beta-citronellol, linalool, alpha-terpineol, eucalyptol (1,8-cineole), fenchol and camphor.

5. The aerosolisable material according to claim 4, wherein each terpene in the terpene block is selected from the group consisting of limonene, terpinolene, beta-myrcene, beta- ocimene, camphene, alpha-pinene, beta-pinene, linalyl acetate, geranyl acetate, betacitronellol, linalool, alpha-terpineol, eucalyptol (1,8-cineole), fenchol and camphor.

6. The aerosolisable material according to any proceeding claim, wherein the terpene block comprises limonene, linalyl acetate, beta-citronellol and linalool.

7. The aerosolisable material according to any proceeding claim, wherein the propylene glycol is present in an amount of at least 60%w/w based on the total weight of the aerosolisable material.

8. The aerosolisable material according to claim 7, wherein the propylene glycol is present in an amount of at least 70%w/w based on the total weight of the aerosolisable material.

9. The aerosolisable material according to any one of the preceding claims, wherein the carrier constituent further comprises one or more of glycerol, triethylene glycol, tetraethylene glycol, 1 ,3-butylene glycol, erythritol, meso-Erythritol, ethyl vanillate, ethyl laurate, a diethyl suberate, triethyl citrate, triethylene glycol diacetate, triacetin, a diacetin mixture, benzyl benzoate, benzyl phenyl acetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate.

10. The aerosolisable material according to claim 9, wherein the carrier constituent further comprises glycerol.

11. The aerosolisable material according to claim 10, wherein glycerol is present in an amount of at least 20%w/w based on the total weight of the aerosolisable material.

12. The aerosolisable material according to claim 10 or 11, wherein glycerol is present in an amount of at least 30%w/w based on the total weight of the aerosolisable material.

13. The aerosolisable material according to any one of claims 10 to 12, wherein, based on the total amount of propylene glycol and glycerol in the aerosolisable material, the aerosolisable material comprises:

60 to 90%w/w propylene glycol; and

40 to 10%w/w glycerol.

14. The aerosolisable material according to claim 13, wherein, based on the total amount of propylene glycol and glycerol in the aerosolisable material, the aerosolisable material comprises:

70 to 80%w/w propylene glycol; and

30 to 20%w/w glycerol.

15. The aerosolisable material according to claim 13, wherein, based on the total amount of propylene glycol and glycerol in the aerosolisable material, the aerosolisable material comprises about 70%w/w propylene glycol and about 30% glycerol.

16. The aerosolisable material according to any one of the preceding claims, wherein the aerosolisable material further comprises at least one cannabinoid.

17. The aerosolisable material according to claim 16, wherein the cannabinoid is cannabidiol.

18. The aerosolisable material according to claim 16 or claim 17, wherein the cannabinoid is present in the aerosolisable material in an amount of 10mg/ml of material or more.

19. The aerosolisable material according to claim 18, wherein the cannabinoid is present in the aerosolisable material in an amount of 30mg/ml of material or more.

20. The aerosolisable material according to claim 16 or claim 17, wherein the cannabinoid is present in the aerosolisable material in an amount of at least 1%w/w based on the total weight of the aerosolisable material.

21. The aerosolisable material according to claim 20, wherein the cannabinoid is present in the aerosolisable material in an amount of at least 2.5%w/w based on the total weight of the aerosolisable material.

22. The aerosolisable material according to claim 20, wherein the cannabinoid is present in the aerosolisable material in an amount of at least 5%w/w based on the total weight of the aerosolisable material.

23. The aerosolisable material according to any one of the preceding claims, wherein the terpene block is present in the aerosolisable material in an amount of at least 0.5%w/w based on the total weight of the aerosolisable material.

24. The aerosolisable material according to claim 23, wherein the terpene block is present in the aerosolisable material in an amount of at least 1%w/w based on the total weight of the aerosolisable material.

25. The aerosolisable material according to any one of the preceding claims, wherein the aerosolisable material does not comprise a surface active constituent.