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WO2024020219A1 - Instrument d'imagerie du cancer multispectral - Google Patents

Instrument d'imagerie du cancer multispectral Download PDF

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Publication number
WO2024020219A1
WO2024020219A1 PCT/US2023/028401 US2023028401W WO2024020219A1 WO 2024020219 A1 WO2024020219 A1 WO 2024020219A1 US 2023028401 W US2023028401 W US 2023028401W WO 2024020219 A1 WO2024020219 A1 WO 2024020219A1
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WIPO (PCT)
Prior art keywords
skin
measurement information
patient
light
spectral
Prior art date
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Ceased
Application number
PCT/US2023/028401
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English (en)
Inventor
Nasser Peyghambarian
William Wolfe
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University of Arizona
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University of Arizona
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Filing date
Publication date
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Publication of WO2024020219A1 publication Critical patent/WO2024020219A1/fr
Anticipated expiration legal-status Critical
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/02—Details
    • G01J1/0228—Control of working procedures; Failure detection; Spectral bandwidth calculation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2803—Investigating the spectrum using photoelectric array detector
    • G01J2003/2806—Array and filter array

Definitions

  • the prior techniques are not imaging techniques, do not produce images or information based on detector arrays that measure regions of interest with fine spatial granularity, and only rely on fluorescence spectra; also, some prior systems primarily rely on the amplitude of the measured value, which can be unreliable.
  • BRIEF SUMMARY OF THE INVENTION It is an objective of the present invention to provide systems and methods that allow for the implementation of multispectral optics for accurate and efficient identification of skin cancers, as specified in the independent claims. Embodiments of the invention are given in the dependent claims. Embodiments of the present invention can be freely combined with each other if they are not mutually exclusive.
  • the disclosed embodiments improve on prior techniques for detecting skin cancers and not only show whether or not a particular lesion is malignant, but they also identify the areal extent of that malignancy and do so almost instantaneously.
  • the improvements are achieved in part by obtaining several images in several spectral bands and using this information to infer the spectral shape of the region in question, which can then be compared to a reference or a normal.
  • One example multispectral cancer detection device is implemented as a portable, handheld optical instrument (e.g., about the size and shape of a hair dryer) that illuminates the subject area and forms images of that area in several spectral bands using, for example, a camera or a microscope lens, and an array of detectors for converting the photons to electrons.
  • the spectral information is used to determine the status of the imaged area, benign or malignant, using an incorporated algorithm and a multicolor display.
  • the illumination spot can be used to target and identify the location of inspection.
  • the display can show the exact location of malignant, normal, and uncertain skin. It can be powered by batteries, a normal wall current, or both.
  • One basic configuration of the disclosed multispectral imaging system includes a camera that includes a lens and a ring of LED sources around the periphery of the lens, where the lens focuses the object on an array of detectors.
  • LEDs of several different colors illuminate the subject in sequence and each individual, colored image is recorded.
  • the captured data are processed by a computing engine and images of the normal and malignant areas are displayed in different colors.
  • a medical technician holds a camera-like device about 12 to 18 inches from the patient and pulls the trigger. The camera does the rest.
  • the camera includes the appropriate computational components (e.g., a processor, a memory, etc.) that can process the information and a display for presenting the images.
  • the information associated with captured images is transferred to an external device (e.g., a local computer, which is in just about every medical facility, a processing device on a network, such as a cloud location); the information is then processed and corresponding images are displayed on a local or remote display.
  • the processing of the information is immediate, and the results are obtained quickly.
  • One of the unique and inventive technical features of the present invention is obtaining several images in several spectral bands and using this information to infer the spectral shape of the region in question, which can then be compared to a reference or a normal spectral shape.
  • the technical feature of the present invention advantageously provides for near-instantaneous determination of whether or not a particular lesion is malignant as well as the areal extent of that malignancy. None of the presently known prior references or work has the unique inventive technical feature of the present invention. [0011] Any feature or combination of features described herein are included within the scope of the present invention provided that the features included in any such combination are not mutually inconsistent as will be apparent from the context, this specification, and the knowledge of one of ordinary skill in the art. Additional advantages and aspects of the present invention are apparent in the following detailed description and claims.
  • FIG.1 illustrates one implementation of the camera in accordance with an example embodiment of the present invention.
  • FIG.2A illustrates some of the components of the disclosed multispectral cancer imaging instrument in accordance with some example embodiments of the present invention.
  • FIG. 2B illustrates a flow chart of a method for multispectral cancer imaging in accordance with some example embodiments of the present invention.
  • FIG.3 illustrates a configuration of the multispectral imaging device in accordance with an alternate embodiment of the present invention.
  • FIG.4 illustrates an example filter arrangement comprising a filter wheel that is positioned in front of the detector array.
  • FIG.5 illustrates an example of the use of the multispectral imager in a clinical setting.
  • FIG. 6 illustrates a set of example plots associated with healthy skin, basal cell carcinoma, squamous cell carcinoma, and malignant melanoma fluorescence and reflection spectra that highlight these differences.
  • FIG.7 illustrates a graph representing a skin cancer detection algorithm in which the hypothetical cancerous spectrum is represented by the top line and the normal spectrum is represented by the bottom line.
  • detector array is defined herein as a series of image sensors. Each image sensor is configured to measure the intensity of light directed into it. Each sensor is made up of individual units, which are called pixels. Each pixel measures the intensity of light by detecting the number of photons that reach the pixel. This information is relayed to the electronics as a voltage value which can then be recorded.
  • spectral shape is defined herein as the form of a feature, observed in spectroscopy, corresponding to an energy change in an atom, molecule, or ion.
  • the present invention features a multispectral optical system (100) for the identification of skin cancers.
  • the system (100) may comprise an illumination component (110) comprising one or more light sources (115) configured to shine light onto a patient’s skin.
  • the system (100) may further comprise an imaging component (120), comprising at least a lens (122) or a mirror (124), and a detector array (126) that includes a plurality of detectors configured to receive light from the patient’s skin after illumination by the one or more light sources (115).
  • the system (100) may further comprise a processor (132) and a memory component (134) comprising computer-readable instructions thereon.
  • the computer-readable instructions upon execution by the processor (132) configure the processor (132) to receive measurement information associated with the light received at the detector array (126) at a plurality of wavelengths or bands of wavelengths, determine a shape of a spectral response associated with the measurement information based on relative amplitude values of the measurement information, and identify, based on the shape of the spectral response, whether the measurement information is indicative of a cancer or a healthy skin sample for display as part of one or more images of the patient’s skin.
  • the one or more light sources (115) may include a plurality of light sources. Each light source may be configured to emit light in a particular spectral band that is different from the spectral bands of other light sources.
  • the plurality of light sources (115) may include light emitting devices (LED), a laser light source, an incandescent light, or a combination thereof.
  • the instructions upon execution by the processor (132) may configure the processor (132) to sequentially operate each of the plurality of light sources and to sequentially collect the measurement information upon illumination of the patent’s skin with a corresponding light source.
  • the one or more light sources (115) may include a broadband light source, and the imaging component (120) may include spectral discrimination means for allowing only a portion of the spectral content of the light received from the patient’s skin to reach the detector array (126) at any given time.
  • the spectral discrimination means may comprise a plurality of spectral filters that are configured to be sequentially positioned in front of the detector array (126).
  • the plurality of spectral filters may be (a) part of a filter wheel or arranged as a line of filters.
  • the spectral discrimination means may comprise a grating or a prism configured to separate spectral contents of the light received from the patient’s skin.
  • the illumination component (110) may include a lens (122) configured to project the illumination from the broadband light source onto the patient’s skin.
  • the imaging component (120) may include a scanning mirror (124) to enable the acquisition of images from different locations of the patient’s skin.
  • the multispectral optical system (100) may be implemented as a handheld device and may include one or more batteries for supplying power to the one or more light sources (115), to the detector array (126), and to the processor (132) and the memory component (134). [0027]
  • the system (100) may further include a display (140) for displaying the one or more images of the patient’s skin, or a portion thereof.
  • the one or more images may be color coded to indicate at least one of a presence or an absence of cancerous regions.
  • the plurality wavelengths or bands of wavelengths may consist of eight distinct wavelengths or bands of wavelengths.
  • the spectral response associated with the measurement information may correspond to a reflection or fluorescence spectrum of the patient’s skin.
  • determination as to whether the measurement information is indicative of healthy skin may be made based on a comparison of the shape of the spectral response shape to a shape of a healthy skin spectral response associated with the patient.
  • the processor may be configured to communicate with an external device to perform one or both of the following operations: (a) process at least part of the measurement information or (2) provide information for displaying the one or more images of the patient’s skin.
  • the instructions upon execution by the processor (132) may configure the processor (132) to determine the shape of the spectral response by in part: computing a first and a second ratio.
  • the first ratio may correspond to a measured amplitude value of the received light at a first wavelength of the plurality wavelengths to a measured amplitude value at a second wavelength of the plurality wavelengths
  • the second ratio may correspond to the measured amplitude value at the second wavelength to a measured amplitude value at a third wavelength of the plurality wavelengths.
  • the instructions upon execution by the processor (132) may configure the processor (132) to identify whether the measurement information is indicative of a cancer or healthy skin by computing a difference between the shape of the spectral response obtained from the measurement information to a spectral response shape associated with healthy skin.
  • identification, based on the shape of the spectral response, whether the measurement information is indicative of a cancer or healthy skin may be carried out at a detector-by-detector granularity level using the measurement information.
  • the present invention features a method for the identification and location of skin cancers on a patient’s skin.
  • the method may comprise illuminating the patient’s skin with one or more light sources (115), receiving light from the patient’s skin at a detector array (126) upon illumination by the one or more light sources (115), obtaining measurement information associated with the light received at the detector array (126) at a plurality wavelengths or bands of wavelengths, determining a shape of a spectral response associated with the measurement information based on relative amplitude values of the measurement information, and identifying, based on the shape of the spectral response, whether the measurement information is indicative of a cancer or a healthy skin for display as part of one or more images of the patient’s skin.
  • identifying, based on the shape of the spectral response, whether the measurement information may be indicative of a cancer or healthy skin includes determining, at detector-by- detector granularity level, whether the measurement information is indicative of a cancer or healthy skin.
  • determining the shape of the spectral response may include computing a first and a second ratio. The first ratio may correspond to a measured amplitude value of the received light at a first wavelength of the plurality wavelengths to a measured amplitude value at a second wavelength of the plurality wavelengths, and the second ratio may correspond to the measured amplitude value at the second wavelength to a measured amplitude value at a third wavelength of the plurality wavelengths.
  • identifying whether the measurement information may be indicative of a cancer or healthy skin by computing a difference between the shape of the spectral response obtained from the measurement information to a spectral response shape associated with healthy skin.
  • FIG.1 illustrates one implementation of a camera in accordance with an example embodiment (left); a standard SLR camera (right) is also illustrated for comparison. The depicted camera is about the same size as the SLR camera, and its shape resembles a hair dryer.
  • FIG.2A illustrates some of the components of the disclosed multispectral cancer imaging instrument in accordance with some example embodiments. As illustrated, LED lights surround the periphery of the window (e.g. front of the camera) and illuminate the skin (not shown).
  • FIG.3 illustrates a configuration of the multispectral imaging device in accordance with an alternate embodiment.
  • a projection subsection includes a light source (e.g., a broadband light source) and a lens for illuminating the object (e.g., a patient’s hand).
  • the imaging component includes a lens and a detector array optically coupled to the lens, which is communicatively coupled to the electronics; the lens is positioned to receive the light from the object (based on reflectance and/or fluorescence) and direct it into the detector array.
  • the electronics are then configured to process the measurement information obtained from the detector array, identify the cancerous/healthy regions, and to produce the corresponding images.
  • the imaging component may further include a scanning mirror to facilitate the collection of images from across different sections of the object.
  • the imaging component may further include a beamsplitter (150) configured to split light emitted by the illumination component into two beams such that a first beam is directed towards the object and the second beam is directed towards the imaging component to act as a reference. Both the mirror and the beamsplitter (150) may be scanned to cover various portions of the afflicted area.
  • a filter (described below) can be positioned in front of the detector array and can have, for example, ten positions that are configured as part of a wheel in front of the detector array.
  • a display (140) can be provided to allow the images to be viewed.
  • One example implementation of the imager has a field of view of 5 cm by 5 cm with pixel sizes of 1 mm. The device can be held about 10 cm from the object.
  • the imaging device can include a 30 mm diameter lens with a 90 mm focal length.
  • the display (140) can be a standard LED display.
  • the electronics may comprise a processor configured to execute computer- readable instructions, and a memory component comprising computer-readable instructions for receiving measurement information associated with the light received at the detector array at a plurality of wavelengths or bands of wavelengths, determining a shape of a spectral response associated with the measurement information based on relative amplitude values of the measurement information, and identify, based on the shape of the spectral response, whether the measurement information is indicative of a cancer or a healthy skin sample for display as part of one or more images of the patient’s skin.
  • FIG.4 illustrates a filter wheel that is positioned in front of the detector array. The wheel is rotated to allow each filter to sequentially cover the detector array. Only four of many possible colored filters are shown. Each filter can completely cover the entire detector array.
  • FIG.4 illustrates an alternate filter arrangement in which different filters are positioned in a line and sequentially cover the array. The selection of a filter configuration of FIGs. 1 and 4 can depend upon the design and compactness considerations.
  • FIG.5 illustrates an example of the use of the multispectral imager in a clinical setting. The doctor or an assistant holds the multispectral camera at a particular distance from the patient. The camera records the images that are displayed on the computer on the counter.
  • the procedure is completely non-invasive. It is like taking a picture of the patient.
  • false color images of the regions of normal and malignancy can be displayed on the rear of the camera and on a separate screen (e.g., a computer monitor).
  • the illumination levels from the LED’s are less than the illumination on a normal desktop or from a standard photographic flash lamp.
  • the disclosed embodiments rely on measured differences between the optical spectra of malignant and healthy skin as part of an algorithm to identify the various types of malignancies.
  • FIG.6 illustrates a set of example plots associated with healthy skin, basal cell carcinoma, squamous cell carcinoma, and malignant melanoma fluorescence and reflection spectra that highlight these differences.
  • ratios can be repeated for an appropriate number of wavelengths, and the root mean square (RMS) difference of the ratios is determined to identify the type of cancer-based on the collection of measured values at multiple wavelengths.
  • RMS root mean square
  • the shape of the spectra can be estimated to effectuate the cancer diagnosis with a single detector (e.g., pixel-level) resolution.
  • a single detector e.g., pixel-level
  • Fluorescent imaging requires the use of a narrow- band illuminator in the shortwave end of the spectrum and a set of filters sequenced over the array.
  • the illumination can be a set of narrow bands and the array unfiltered or the illumination can be broadband and the array filtered.
  • An example procedure using the multispectral imaging device of FIG. 2A includes illuminating the target area (e.g., a patient’s hand) with a first one of a plurality of LEDs, capturing an image via the detector array. The received light can be based on reflection or fluorescence. The procedure is repeated for additional LEDs at different wavebands.
  • the results are processed, and the cancerous and healthy regions are identified with high spatial granularity (in accordance with the desired resolution).
  • the spectral measurements are carried out at eight different wavelengths.
  • a similar procedure can be carried out using the imaging device of FIG. 3, but instead of sequentially illuminating the LEDs, the spectral measurements are carried out by illuminating the subject by the broadband light source and changing the spectral filters on the detector array in sequence to obtain the spectral measurements.
  • the spectral characteristics of the healthy skin can be determined for each particular patient by conducting measurements on a healthy portion of that patient’s skin before or after the measurements on the region that is suspected of being cancerous.
  • the healthy-skin spectral data can be obtained from a database that includes pre-stored data associated with the individual patient (e.g., obtained in a prior year), or spectral information associated with patients with similar skin tone and/or ethnic background.
  • a multispectral imaging system for the detection and location of skin cancers.
  • the system includes an optical illumination system and an optical imaging system that includes an array of detectors.
  • the system is operated in accordance with a method for selecting various wavelengths, a data processing method for distinguishing between benign and malignant cells, and a method for displaying the results.
  • the disclosed multispectral imagers can operate based on either fluorescent or reflected spectra using (a) narrow-band illuminators and broadband receivers or (b) a broadband illuminator and multiple narrow-band receivers.
  • the narrow band illuminators can be, for example, either LED's, diode lasers, or other appropriate sources like small incandescent bulbs. If the receivers are narrow band, this can be accomplished with filters (as described earlier) or via prisms or gratings that produce spectrally separated light that is then incident on the detector array.
  • the discrimination between malignant and healthy skin is accomplished by comparing the shape of the spectrum to that of a norm, not the amplitude, and is done by an adequate sampling of the spectrum in several narrow bands.
  • Optical imaging devices that may be used in one or another of these embodiments include lenses, mirrors, and combinations of them. The number and type and combination depend upon the imaging requirements like the resolution, field of view, and spectral coverage. For instance, a simple spherical mirror has no chromatic aberration but suffers from spherical aberration. A simple parabolic mirror does not have spherical aberration but suffers from a coma toward the edges of the field of view. A single spherical lens suffers from spherical aberration, chromatic aberration, coma, and other aberrations. These aberrations are corrected by the use of additional lenses or mirrors or corrector plates.
  • the illumination is in the shortwave region of the visible spectrum or the near ultraviolet at about 400 nm. It is shone as a prescribed area on the skin by conventional optical projector means.
  • the receiving optical imaging element is a combination of lenses and or mirrors. The detection can be accomplished with an array of photodetectors.
  • the spectral channels are determined by filters on rows of the array.
  • the images are obtained by the motion of a scanning mirror. The spectra are the fluorescence of the skin.
  • the spectral analysis algorithm is based on the relative values of the signals in the respective wavelength bands to determine the general shape of the spectral curve.
  • the display can be generated in two or more colors by a conventional LED display device.
  • One example of a portable, multispectral, optical device for the identification and location of skin cancers by analysis of their reflection spectra includes means for illumination, imaging, spectral analysis, and displaying their locations.
  • the illumination can be generated by three or more light-emitting diodes in three or more narrow spectral bands.
  • the illumination can be generated by three or more diode lasers in three or more narrow spectral bands.
  • the illumination can be generated by three or more filtered incandescent or another conventional source in three or more narrow spectral bands.
  • the receiving optical imaging element in the above portable device includes a combination of lenses and or mirrors, and the detection is accomplished with an array of photodetectors.
  • the illumination is generated by a panchromatic source such as an incandescent bulb. In this configuration, spectral measurements are carried out in several colors and are determined by a set of filters that sequentially cover the detector array.
  • EXAMPLE [0051] The following are non-limiting examples of application of the presently claimed invention.
  • EXAMPLE 1 A 47-year-old male patient with a new dark spot on his arm comes in for an imaging appointment to make sure it is not cancerous. A dermatologist examines the spot and determines that the spot could possibly be a melanoma. The dermatologist then prepares the multispectral imaging device of the present invention to be used to image the spot. The device is stabilized against the spot and the illumination component is actuated such that light is directed towards the spot. This light is reflected from the spot to the imaging component and several spectral images are captured. The imaging component transmits these images to the electronics and the spectral shapes of these images are compared to healthy and cancerous spectral shapes stored in memory.
  • EXAMPLE 2 A 50-year-old male patient with a new raised red region on his shoulder comes in for an imaging appointment to make sure it is not cancerous. A dermatologist examines the spot and determines that the spot could possibly be a squamous cell carcinoma. The dermatologist then prepares the multispectral imaging device of the present invention to be used to image the region.
  • the device is stabilized against the region and the illumination component is actuated such that light is directed towards the region. This light is reflected from the region to the imaging component and several spectral images are captured.
  • the imaging component transmits these images to the electronics and the spectral shapes of these images are compared to healthy and cancerous spectral shapes stored in memory. The comparison determines that the spot matches the spectral shape of a squamous cell carcinoma sample in terms of fluorescence intensity and reflectance (see FIG.6).
  • the dermatologist prescribes a treatment plan to the patient.
  • Various operations disclosed herein can be implemented using a processor/controller which is configured to include, or be coupled to, a memory that stores processor-executable code that causes the processor/controller to carry out various computations and processing of information.
  • the processor/controller can further generate and transmit/receive suitable information to/from the various system components, as well as suitable input/output (IO) capabilities (e.g., wired or wireless) to transmit and receive commands and/or data.
  • IO input/output
  • the processor/controller may control the operations of the light sources and/or the detectors, may receive information associated with measured values from the detector array, and to further process that information to determine the cancerous and healthy regions, as well as produce the image data suitable for display.
  • Various information and data processing operations described herein may be implemented in one embodiment by a computer program product, embodied in a computer-readable medium, including computer- executable instructions, such as program code, executed by computers in networked environments.
  • a computer-readable medium may include removable and non-removable storage devices including, but not limited to, Read Only Memory (ROM), Random Access Memory (RAM), compact discs (CDs), and digital versatile discs (DVD), etc. Therefore, the computer-readable media that is described in the present application comprises non-transitory storage media.
  • program modules may include routines, programs, objects, components, data structures, etc. that perform particular tasks or implement particular abstract data types.
  • the computer system can include a desktop computer, a laptop computer, a tablet, or the like and can include digital electronic circuitry, firmware, hardware, memory, a computer storage medium, a computer program, a processor (including a programmed processor), or the like.
  • the computing system may include a desktop computer with a screen and a tower.
  • the tower can store digital images in binary form.
  • the images can also be divided into a matrix of pixels.
  • the pixels can include a digital value of one or more bits, defined by the bit depth.
  • the network or a direct connection interconnects the imaging apparatus and the computer system.
  • the term "processor” encompasses all kinds of apparatus, devices, and machines for processing data, including by way of example a programmable microprocessor, a computer, a system on a chip, multiple ones, or combinations, of the foregoing.
  • the apparatus can include special purpose logic circuitry, e.g., an FPGA (field programmable gate array) or an ASIC (application-specific integrated circuit).
  • the apparatus also can include, in addition to hardware, code that creates an execution environment for the computer program in question, e.g., code that constitutes processor firmware, a protocol stack, a database management system, an operating system, a cross-platform runtime environment, a virtual machine, or a combination of one or more of them.
  • the apparatus and execution environment can realize various computing model infrastructures, such as web services, distributed computing, and grid computing infrastructures.
  • the processor may include one or more processors of any type, such as central processing units (CPUs), graphics processing units (GPUs), special-purpose signal or image processors, and field-programmable gate arrays (FPGAs), tensor processing units (TPUs), and so forth.
  • CPUs central processing units
  • GPUs graphics processing units
  • FPGAs field-programmable gate arrays
  • TPUs tensor processing units
  • a computer program (also known as a program, software, software application, script, or code) can be written in any form of programming language, including compiled or interpreted languages, declarative or procedural languages, and it can be deployed in any form, including as a stand-alone program or as a module, component, subroutine, object, or other units suitable for use in a computing environment.
  • a computer program may, but need not, correspond to a file in a file system.
  • a program can be stored in a portion of a file that holds other programs or data (e.g., one or more scripts stored in a markup language document), in a single file dedicated to the program in question, or in multiple coordinated files (e.g., files that store one or more modules, subprograms, or portions of code).
  • a computer program can be deployed to be executed on one computer or on multiple computers that are located at one site or distributed across multiple sites and interconnected by a communication network.
  • Embodiments of the subject matter described in this specification can be implemented as one or more computer programs, i.e., one or more modules of computer program instructions encoded on a computer storage medium for execution by, or to control the operation of, data processing apparatus. Any of the modules described herein may include logic that is executed by the processor(s). "Logic,” as used herein, refers to any information having the form of instruction signals and/or data that may be applied to affect the operation of a processor. Software is an example of logic.
  • Logic may be formed from signals stored on a computer-readable medium such as memory that, in an exemplary embodiment, may be a random access memory (RAM), read-only memories (ROM), erasable / electrically erasable programmable read-only memories (EPROMS/EEPROMS), flash memories, etc.
  • Logic may also comprise digital and/or analog hardware circuits, for example, hardware circuits comprising logical AND, OR, XOR, NAND, NOR, and other logical operations.
  • Logic may be formed from combinations of software and hardware.
  • logic On a network, logic may be programmed on a server or a complex of servers. A particular logic unit is not limited to a single logical location on the network. Moreover, the modules need not be executed in any specific order.
  • a computer storage medium can be, or can be included in, a computer-readable storage device, a computer-readable storage substrate, a random or serial access memory array or device, or a combination of one or more.
  • a computer storage medium is not a propagated signal, a computer storage medium can be a source or destination of computer program instructions encoded in an artificially generated propagated signal.
  • the computer storage medium can also be or can be included in one or more separate physical components or media (e.g., multiple CDs, disks, or other storage devices).
  • the operations described in this specification can be implemented as operations performed by a data processing apparatus on data stored on one or more computer-readable storage devices or received from other sources.
  • Program code embodied on a computer-readable medium may be transmitted using any appropriate medium, including but not limited to wireless, wireline, optical fiber cable, R.F, etc., or any suitable combination of the foregoing.
  • Computer program code for carrying out operations for aspects of the present disclosure may be written in any combination of one or more programming languages, including an object- oriented programming language such as Java, Smalltalk, C++, or the like, and conventional procedural programming languages, such as the "C" programming language or similar programming languages.
  • the program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer, or entirely on the remote computer or server.
  • the remote computer may be connected to the user's computer through any type of network, including a local area network (LAN) or a wide area network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet Service Provider).
  • LAN local area network
  • WAN wide area network
  • processors suitable for the execution of a computer program include, by way of example, both general and special purpose microprocessors, and any one or more processors of any kind of digital computer.
  • a processor will receive instructions and data from a read-only memory or a random access memory, or both.
  • the essential elements of a computer are a processor for performing actions following instructions and one or more memory devices for storing instructions and data.
  • a computer will also include, or be operatively coupled to receive data from or transfer data to, or both, one or more mass storage devices for storing data, e.g., magnetic, magneto-optical disks, or optical disks.
  • mass storage devices for storing data, e.g., magnetic, magneto-optical disks, or optical disks.
  • a computer can be embedded in another device, e.g., a mobile telephone, a personal digital assistant (PDA), a mobile audio or video player, a game console, a Global Positioning System (GPS) receiver, or a portable storage device (e.g., a universal serial bus (USB) flash drive), to name just a few.
  • Devices suitable for storing computer program instructions and data include all forms of non-volatile memory, media, and memory devices, including by way of example semiconductor memory devices, e.g., EPROM, EEPROM, and flash memory devices; magnetic disks, e.g., internal hard disks or removable disks; magneto-optical disks; and CD-ROM and DVD-ROM disks.
  • the figures are representative only and the claims are not limited by the dimensions of the figures.
  • descriptions of the inventions described herein using the phrase “comprising” includes embodiments that could be described as “consisting essentially of” or “consisting of”, and as such the written description requirement for claiming one or more embodiments of the present invention using the phrase “consisting essentially of” or “consisting of” is met.

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  • Biomedical Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
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  • Dermatology (AREA)
  • General Physics & Mathematics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

L'invention concerne un système optique multispectral pour l'identification de cancers de la peau. Le système peut comprendre un composant d'éclairage configuré pour projeter de la lumière sur la peau d'un patient, un composant d'imagerie, et un réseau de détecteurs configuré pour recevoir la lumière provenant de la peau du patient après l'éclairage par la ou les sources de lumière. Le système peut être configuré pour recevoir des informations de mesure associées à la lumière reçue au niveau du réseau de détecteurs à une pluralité de longueurs d'onde ou de bandes de longueurs d'onde, déterminer une forme d'une réponse spectrale associée aux informations de mesure sur la base de valeurs d'amplitude relative des informations de mesure, et identifier, sur la base de la forme de la réponse spectrale, si les informations de mesure indiquent un cancer ou un échantillon de peau sain pour un affichage en tant que partie d'une ou plusieurs images de la peau du patient.
PCT/US2023/028401 2022-07-21 2023-07-21 Instrument d'imagerie du cancer multispectral Ceased WO2024020219A1 (fr)

Applications Claiming Priority (2)

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US202263391254P 2022-07-21 2022-07-21
US63/391,254 2022-07-21

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WO2024020219A1 true WO2024020219A1 (fr) 2024-01-25

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008889A (en) * 1997-04-16 1999-12-28 Zeng; Haishan Spectrometer system for diagnosis of skin disease
US20090318815A1 (en) * 2008-05-23 2009-12-24 Michael Barnes Systems and methods for hyperspectral medical imaging
US20140187968A1 (en) * 2012-12-27 2014-07-03 Christie Digital Systems Canada Inc. Spectral imaging with a color wheel
US20190090751A1 (en) * 2016-03-07 2019-03-28 Daegu Gyeongbuk Institute Of Science And Technology Multispectral imaging device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008889A (en) * 1997-04-16 1999-12-28 Zeng; Haishan Spectrometer system for diagnosis of skin disease
US20090318815A1 (en) * 2008-05-23 2009-12-24 Michael Barnes Systems and methods for hyperspectral medical imaging
US20140187968A1 (en) * 2012-12-27 2014-07-03 Christie Digital Systems Canada Inc. Spectral imaging with a color wheel
US20190090751A1 (en) * 2016-03-07 2019-03-28 Daegu Gyeongbuk Institute Of Science And Technology Multispectral imaging device

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