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WO2024006971A3 - Antimalarial compounds - Google Patents

Antimalarial compounds Download PDF

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Publication number
WO2024006971A3
WO2024006971A3 PCT/US2023/069475 US2023069475W WO2024006971A3 WO 2024006971 A3 WO2024006971 A3 WO 2024006971A3 US 2023069475 W US2023069475 W US 2023069475W WO 2024006971 A3 WO2024006971 A3 WO 2024006971A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
compositions
antimalarial compounds
malarial
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2023/069475
Other languages
French (fr)
Other versions
WO2024006971A2 (en
Inventor
Anil Kumar Gupta
Arnab Chatterjee
James PEDROARENA
Armen NAZARIAN
Frank Weiss
Case W. MCNAMARA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of WO2024006971A2 publication Critical patent/WO2024006971A2/en
Publication of WO2024006971A3 publication Critical patent/WO2024006971A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Disclosed herein are compounds and compositions comprising the compounds of Formula I (I) wherein all variables are as defined herein. Further disclosed are methods for using the above compounds and compositions comprising the above compounds for the prevention, amelioration, or treatment of malarial infections alone or in combination with other therapeutic agents, including additional anti-malarial drugs.
PCT/US2023/069475 2022-07-01 2023-06-30 Antimalarial compounds Ceased WO2024006971A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202263357855P 2022-07-01 2022-07-01
US63/357,855 2022-07-01
US202363492514P 2023-03-28 2023-03-28
US63/492,514 2023-03-28

Publications (2)

Publication Number Publication Date
WO2024006971A2 WO2024006971A2 (en) 2024-01-04
WO2024006971A3 true WO2024006971A3 (en) 2024-04-11

Family

ID=89381573

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/069475 Ceased WO2024006971A2 (en) 2022-07-01 2023-06-30 Antimalarial compounds

Country Status (1)

Country Link
WO (1) WO2024006971A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160108051A1 (en) * 2009-07-09 2016-04-21 Novartis Ag Compounds and compositions for the treatment of parasitic disease
US20180237443A1 (en) * 2015-11-09 2018-08-23 Astrazeneca Ab Chemical Compounds
US20180303837A1 (en) * 2017-04-24 2018-10-25 Novartis Ag Therapeutic regimen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160108051A1 (en) * 2009-07-09 2016-04-21 Novartis Ag Compounds and compositions for the treatment of parasitic disease
US20180237443A1 (en) * 2015-11-09 2018-08-23 Astrazeneca Ab Chemical Compounds
US20180303837A1 (en) * 2017-04-24 2018-10-25 Novartis Ag Therapeutic regimen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KUHEN ET AL.: "KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 58, September 2014 (2014-09-01), pages 5060 - 5067, XP055486520, DOI: 10.1128/AAC.02727-13 *

Also Published As

Publication number Publication date
WO2024006971A2 (en) 2024-01-04

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