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WO2024006824A3 - Protéines effectrices, compositions, systèmes et leurs procédés d'utilisation - Google Patents

Protéines effectrices, compositions, systèmes et leurs procédés d'utilisation Download PDF

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Publication number
WO2024006824A3
WO2024006824A3 PCT/US2023/069253 US2023069253W WO2024006824A3 WO 2024006824 A3 WO2024006824 A3 WO 2024006824A3 US 2023069253 W US2023069253 W US 2023069253W WO 2024006824 A3 WO2024006824 A3 WO 2024006824A3
Authority
WO
WIPO (PCT)
Prior art keywords
systems
methods
effector proteins
compositions
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2023/069253
Other languages
English (en)
Other versions
WO2024006824A2 (fr
Inventor
Aaron DELOUGHERY
David PAEZ-ESPINO
Benjamin Julius RAUCH
Fnu YUNANDA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mammoth Biosciences Inc
Original Assignee
Mammoth Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mammoth Biosciences Inc filed Critical Mammoth Biosciences Inc
Publication of WO2024006824A2 publication Critical patent/WO2024006824A2/fr
Publication of WO2024006824A3 publication Critical patent/WO2024006824A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des compositions, des systèmes et des procédés comprenant des protéines effectrices et leurs utilisations. Ces protéines effectrices peuvent être caractérisées en tant que protéines associées à CRISPR (Cas). Des compositions, systèmes et procédés divers de la présente invention peuvent tirer profit des activités de ces protéines effectrices pour la modification, la détection et l'ingénierie d'acides nucléiques.
PCT/US2023/069253 2022-06-28 2023-06-28 Protéines effectrices, compositions, systèmes et leurs procédés d'utilisation Ceased WO2024006824A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263356382P 2022-06-28 2022-06-28
US63/356,382 2022-06-28

Publications (2)

Publication Number Publication Date
WO2024006824A2 WO2024006824A2 (fr) 2024-01-04
WO2024006824A3 true WO2024006824A3 (fr) 2024-04-25

Family

ID=89381416

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/069253 Ceased WO2024006824A2 (fr) 2022-06-28 2023-06-28 Protéines effectrices, compositions, systèmes et leurs procédés d'utilisation

Country Status (1)

Country Link
WO (1) WO2024006824A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020181102A1 (fr) * 2019-03-07 2020-09-10 The Regents Of The University Of California Polypeptides effecteurs crispr-cas et procédés d'utilisation associés

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020181102A1 (fr) * 2019-03-07 2020-09-10 The Regents Of The University Of California Polypeptides effecteurs crispr-cas et procédés d'utilisation associés

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE GenBank 14 February 2014 (2014-02-14), ANONYMOUS: "PRI0112d_B07_2 - PRI0112d.BR (837) Mixed stage fosmid library of P. pacificus var. California Pristionchus pacificus genomic, genomic survey sequence", XP093167125, Database accession no. CL674666.1 *

Also Published As

Publication number Publication date
WO2024006824A2 (fr) 2024-01-04

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