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WO2024086246A8 - 2-substituted 3,4 a, 5, 7, 8, 8 a-hexahydro-4h-thiop yrano [4,3- d]pyrimidin-4-ones for wound treatment - Google Patents

2-substituted 3,4 a, 5, 7, 8, 8 a-hexahydro-4h-thiop yrano [4,3- d]pyrimidin-4-ones for wound treatment Download PDF

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Publication number
WO2024086246A8
WO2024086246A8 PCT/US2023/035442 US2023035442W WO2024086246A8 WO 2024086246 A8 WO2024086246 A8 WO 2024086246A8 US 2023035442 W US2023035442 W US 2023035442W WO 2024086246 A8 WO2024086246 A8 WO 2024086246A8
Authority
WO
WIPO (PCT)
Prior art keywords
yrano
thiop
hexahydro
pyrimidin
ones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2023/035442
Other languages
French (fr)
Other versions
WO2024086246A2 (en
WO2024086246A3 (en
Inventor
John Joseph Palsted DELGADO
Daniel D. Holsworth
Sarika SARASWATI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eluciderm Inc
Original Assignee
Eluciderm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN202380085227.8A priority Critical patent/CN120500488A/en
Priority to IL320183A priority patent/IL320183A/en
Priority to JP2025522125A priority patent/JP2025535316A/en
Priority to EP23805742.6A priority patent/EP4605084A2/en
Priority to KR1020257016221A priority patent/KR20250093525A/en
Priority to AU2023365200A priority patent/AU2023365200A1/en
Application filed by Eluciderm Inc filed Critical Eluciderm Inc
Publication of WO2024086246A2 publication Critical patent/WO2024086246A2/en
Publication of WO2024086246A3 publication Critical patent/WO2024086246A3/en
Priority to MX2025004545A priority patent/MX2025004545A/en
Anticipated expiration legal-status Critical
Publication of WO2024086246A8 publication Critical patent/WO2024086246A8/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions.
PCT/US2023/035442 2022-10-18 2023-10-18 2-substituted 3,4 a, 5, 7, 8, 8 a-hexahydro-4h-thiop yrano [4,3- djpyrimidin-4-ones for wound treatment Ceased WO2024086246A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IL320183A IL320183A (en) 2022-10-18 2023-10-18 2-substituted 3,4 a, 5, 7, 8, 8 a-hexahydro-4h-thiop yrano [4,3- djpyrimidin-4-ones for wound treatment
JP2025522125A JP2025535316A (en) 2022-10-18 2023-10-18 2-Substituted 3,4a,5,7,8,8a-hexahydro-4H-thiopyrano[4,3-d]pyrimidin-4-ones for wound treatment
EP23805742.6A EP4605084A2 (en) 2022-10-18 2023-10-18 2-substituted 3,4 a, 5, 7, 8, 8 a-hexahydro-4h-thiop yrano [4,3- d]pyrimidin-4-ones for wound treatment
KR1020257016221A KR20250093525A (en) 2022-10-18 2023-10-18 2-Substituted 3,4A,5,7,8,8A-Hexahydro-4H-thiopyrano[4,3-D]pyrimidin-4-ones for wound healing
AU2023365200A AU2023365200A1 (en) 2022-10-18 2023-10-18 2-substituted 3,4 a, 5, 7, 8, 8 a-hexahydro-4h-thiop yrano [4,3- d]pyrimidin-4-ones for wound treatment
CN202380085227.8A CN120500488A (en) 2022-10-18 2023-10-18 2-Substituted 3,4a,5,7,8 a-hexahydro-4H-thiopyrano [4,3-d ] pyrimidin-4-ones for wound treatment
MX2025004545A MX2025004545A (en) 2022-10-18 2025-04-16 2-substituted 3,4 a, 5, 7, 8, 8 a-hexahydro-4h-thiop yrano [4,3- djpyrimidin-4-ones for wound treatment

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202263417257P 2022-10-18 2022-10-18
US63/417,257 2022-10-18
US202263418947P 2022-10-24 2022-10-24
US202263418956P 2022-10-24 2022-10-24
US63/418,956 2022-10-24
US63/418,947 2022-10-24

Publications (3)

Publication Number Publication Date
WO2024086246A2 WO2024086246A2 (en) 2024-04-25
WO2024086246A3 WO2024086246A3 (en) 2024-05-30
WO2024086246A8 true WO2024086246A8 (en) 2025-05-22

Family

ID=88793232

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/035442 Ceased WO2024086246A2 (en) 2022-10-18 2023-10-18 2-substituted 3,4 a, 5, 7, 8, 8 a-hexahydro-4h-thiop yrano [4,3- djpyrimidin-4-ones for wound treatment

Country Status (8)

Country Link
EP (1) EP4605084A2 (en)
JP (1) JP2025535316A (en)
KR (1) KR20250093525A (en)
CN (1) CN120500488A (en)
AU (1) AU2023365200A1 (en)
IL (1) IL320183A (en)
MX (1) MX2025004545A (en)
WO (1) WO2024086246A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025194162A1 (en) * 2024-03-15 2025-09-18 Eluciderm Inc. Pharmaceutical compositions of wnt pathway inhibitors for wound treatment

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US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
KR890002631B1 (en) 1984-10-04 1989-07-21 몬산토 캄파니 Composition of prolonged release of biologically active somatotropin
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (en) 1989-03-22 1991-07-25 Bioresearch Spa USE OF 5 METHYLTHETRAHYDROPHOLIC ACID, 5 FORMYLTHETRAHYDROPHOLIC ACID AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CONTROLLED RELEASE ACTIVE IN THE THERAPY OF MENTAL AND ORGANIC DISORDERS.
PH30995A (en) 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
TW333456B (en) 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US6087324A (en) 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
IT1270594B (en) 1994-07-07 1997-05-07 Recordati Chem Pharm CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION OF LIQUID SUSPENSION MOGUISTEIN
CA2224381A1 (en) 1995-06-27 1997-01-16 Takeda Chemical Industries, Ltd. Method of producing sustained-release preparation
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JP2909418B2 (en) 1995-09-18 1999-06-23 株式会社資生堂 Delayed release microsphere of drug
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EP1142881A4 (en) * 1999-01-14 2003-05-07 Meiji Seika Kaisha Poly(adp-ribose) polymerase inhibitors consisting of pyrimidine derivatives
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HUE060980T2 (en) 2017-10-06 2023-05-28 Eluciderm Inc Compositions and methods for wound treatment
MX2024003105A (en) 2021-09-13 2024-05-24 Eluciderm Inc Composition for use in a method for cartilage regeneration and regrowth following injury.

Also Published As

Publication number Publication date
WO2024086246A2 (en) 2024-04-25
KR20250093525A (en) 2025-06-24
CN120500488A (en) 2025-08-15
WO2024086246A3 (en) 2024-05-30
AU2023365200A1 (en) 2025-05-15
JP2025535316A (en) 2025-10-24
MX2025004545A (en) 2025-06-02
EP4605084A2 (en) 2025-08-27
IL320183A (en) 2025-06-01

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Free format text: 1) APRESENTE NOVAS FOLHAS DOS DESENHOS ADAPTADAS AO ART. 38 INCISO III DA PORTARIA/INPI NO 14/2024, UMA VEZ QUE O CONTEUDO ENVIADO NA PETICAO NO 870250031189 DE 16/04/2025 ENCONTRA-SE FORA DA NORMA NO QUE SE REFERE A NUMERACAO DOS DESENHOS. 2) APRESENTE NOVAS FOLHAS DAS REIVINDICACOES CONTENDO A EXPRESSAO ?CARACTERIZADO POR?, CONFORME ART. 28 INCISO II DA PORTARIA/INPI NO 14/2024, UMA VEZ QUE NEM TODAS AS REIVINDICACOES APRESENTADAS NA PETICAO NO 870250031189 DE 16/04/2025 POSSUEM A EXPRESSAO CITADA. 3) APRESENTE NOVAS FOLHAS DAS REIVINDICACOES ADAPTADAS AO ART. 28 INCISO I DA PORTARIA/INPI NO 14/2024, UMA VEZ QUE O CONTEUDO ENVIADO NA PETICAO NO 870240109481 DE 23/12/2024 ENCONTRA-SE FORA