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WO2024073111A3 - Affinity binding entities directed to b7h6 and methods of use thereof - Google Patents

Affinity binding entities directed to b7h6 and methods of use thereof Download PDF

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Publication number
WO2024073111A3
WO2024073111A3 PCT/US2023/034227 US2023034227W WO2024073111A3 WO 2024073111 A3 WO2024073111 A3 WO 2024073111A3 US 2023034227 W US2023034227 W US 2023034227W WO 2024073111 A3 WO2024073111 A3 WO 2024073111A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
binding entities
affinity binding
entities directed
cars
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2023/034227
Other languages
French (fr)
Other versions
WO2024073111A2 (en
Inventor
Blake AFTAB
Arun BHAT
Kevin Nishimoto
Alexander TEAGUE
Gauri LAMTURE
Beibei Ding
Nitya RAMADOSS
Melinda Au
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adicet Therapeutics Inc
Original Assignee
Adicet Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adicet Therapeutics Inc filed Critical Adicet Therapeutics Inc
Publication of WO2024073111A2 publication Critical patent/WO2024073111A2/en
Publication of WO2024073111A3 publication Critical patent/WO2024073111A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Aspects of the disclosure include affinity-binding entities that target B7 homolog 6 (B7H6), chimeric antigen receptors (CARs) comprising the same, modified immune cells comprising said CARs, and compositions and methods comprising the same for the treatment of conditions associated with B7H6-expression. In embodiments, the modified immune cells are engineered γδ T cells.
PCT/US2023/034227 2022-09-30 2023-09-29 Affinity binding entities directed to b7h6 and methods of use thereof Ceased WO2024073111A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263411988P 2022-09-30 2022-09-30
US63/411,988 2022-09-30

Publications (2)

Publication Number Publication Date
WO2024073111A2 WO2024073111A2 (en) 2024-04-04
WO2024073111A3 true WO2024073111A3 (en) 2024-06-27

Family

ID=90479309

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/034227 Ceased WO2024073111A2 (en) 2022-09-30 2023-09-29 Affinity binding entities directed to b7h6 and methods of use thereof

Country Status (1)

Country Link
WO (1) WO2024073111A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9205148B2 (en) * 2011-04-20 2015-12-08 Medimmune, Llc Antibodies and other molecules that bind B7-H1 and PD-1
US20200237927A1 (en) * 2015-04-13 2020-07-30 Five Prime Therapeutics, Inc. Combination Therapy for Cancer
US20210032658A1 (en) * 2014-04-25 2021-02-04 Bluebird Bio, Inc. Mnd promoter chimeric antigen receptors
US20210340258A1 (en) * 2016-04-15 2021-11-04 Trustees Of Dartmouth College High affinity b7-h6 antibodies and antibody fragments
US20220125884A1 (en) * 2020-10-22 2022-04-28 Gilead Sciences, Inc. INTERLEUKIN-2-Fc FUSION PROTEINS AND METHODS OF USE

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9205148B2 (en) * 2011-04-20 2015-12-08 Medimmune, Llc Antibodies and other molecules that bind B7-H1 and PD-1
US20210032658A1 (en) * 2014-04-25 2021-02-04 Bluebird Bio, Inc. Mnd promoter chimeric antigen receptors
US20200237927A1 (en) * 2015-04-13 2020-07-30 Five Prime Therapeutics, Inc. Combination Therapy for Cancer
US20210340258A1 (en) * 2016-04-15 2021-11-04 Trustees Of Dartmouth College High affinity b7-h6 antibodies and antibody fragments
US20220125884A1 (en) * 2020-10-22 2022-04-28 Gilead Sciences, Inc. INTERLEUKIN-2-Fc FUSION PROTEINS AND METHODS OF USE

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CASTELLANOS SPACE SPACE SPACE SPACE *

Also Published As

Publication number Publication date
WO2024073111A2 (en) 2024-04-04

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