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WO2024064787A3 - Method for determination of double-stranded rna impurity - Google Patents

Method for determination of double-stranded rna impurity Download PDF

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Publication number
WO2024064787A3
WO2024064787A3 PCT/US2023/074734 US2023074734W WO2024064787A3 WO 2024064787 A3 WO2024064787 A3 WO 2024064787A3 US 2023074734 W US2023074734 W US 2023074734W WO 2024064787 A3 WO2024064787 A3 WO 2024064787A3
Authority
WO
WIPO (PCT)
Prior art keywords
stranded rna
double
determination
dsrna
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2023/074734
Other languages
French (fr)
Other versions
WO2024064787A2 (en
Inventor
Eddie Wang
Zheng MENG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ultragenyx Pharmaceutical Inc
Original Assignee
Ultragenyx Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ultragenyx Pharmaceutical Inc filed Critical Ultragenyx Pharmaceutical Inc
Publication of WO2024064787A2 publication Critical patent/WO2024064787A2/en
Publication of WO2024064787A3 publication Critical patent/WO2024064787A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2545/00—Reactions characterised by their quantitative nature
    • C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
    • C12Q2545/101—Reactions characterised by their quantitative nature the purpose being quantitative analysis with an internal standard/control

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Provided are ELISA based methods and compositions and kits for use in said methods, for quantitatively detecting the presence of double stranded RNA (dsRNA) in a sample solution, e.g., a sample solution that comprises dsRNA and messenger RNA (mRNA). Also provided are methods of correlating the presence of dsRNA with potential immunogenicity in a host.
PCT/US2023/074734 2022-09-21 2023-09-21 Method for determination of double-stranded rna impurity Ceased WO2024064787A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263376544P 2022-09-21 2022-09-21
US63/376,544 2022-09-21

Publications (2)

Publication Number Publication Date
WO2024064787A2 WO2024064787A2 (en) 2024-03-28
WO2024064787A3 true WO2024064787A3 (en) 2024-05-02

Family

ID=90455249

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/074734 Ceased WO2024064787A2 (en) 2022-09-21 2023-09-21 Method for determination of double-stranded rna impurity

Country Status (1)

Country Link
WO (1) WO2024064787A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190187031A1 (en) * 2017-12-14 2019-06-20 The Regents Of The University Of Michigan Concentration of analytes
US20190360030A1 (en) * 2002-02-21 2019-11-28 Alere San Diego Inc. Recombinase polymerase amplification

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190360030A1 (en) * 2002-02-21 2019-11-28 Alere San Diego Inc. Recombinase polymerase amplification
US20190187031A1 (en) * 2017-12-14 2019-06-20 The Regents Of The University Of Michigan Concentration of analytes

Also Published As

Publication number Publication date
WO2024064787A2 (en) 2024-03-28

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