[go: up one dir, main page]

WO2023223196A1 - Agencement de buse - Google Patents

Agencement de buse Download PDF

Info

Publication number
WO2023223196A1
WO2023223196A1 PCT/IB2023/055019 IB2023055019W WO2023223196A1 WO 2023223196 A1 WO2023223196 A1 WO 2023223196A1 IB 2023055019 W IB2023055019 W IB 2023055019W WO 2023223196 A1 WO2023223196 A1 WO 2023223196A1
Authority
WO
WIPO (PCT)
Prior art keywords
nozzle
recess
nozzle arrangement
liquid
depth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2023/055019
Other languages
English (en)
Inventor
Adam STUART
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merxin Ltd
Original Assignee
Merxin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US17/745,357 external-priority patent/US20230364360A1/en
Priority claimed from GB2207090.8A external-priority patent/GB2618785B/en
Application filed by Merxin Ltd filed Critical Merxin Ltd
Priority to EP23730903.4A priority Critical patent/EP4514434A1/fr
Publication of WO2023223196A1 publication Critical patent/WO2023223196A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
    • B05B15/60—Arrangements for mounting, supporting or holding spraying apparatus
    • B05B15/65—Mounting arrangements for fluid connection of the spraying apparatus or its outlets to flow conduits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
    • B05B15/50—Arrangements for cleaning; Arrangements for preventing deposits, drying-out or blockage; Arrangements for detecting improper discharge caused by the presence of foreign matter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/26—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with means for mechanically breaking-up or deflecting the jet after discharge, e.g. with fixed deflectors; Breaking-up the discharged liquid or other fluent material by impinging jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
    • B05B15/40—Filters located upstream of the spraying outlets

Definitions

  • This invention relates to the nebulisation of liquids.
  • this invention relates to a nozzle arrangement for delivering a liquid from a liquid delivery device.
  • This invention also relates to a liquid delivery device comprising a nozzle arrangement.
  • Drug delivery devices such as soft mist inhalers (SMIs) can be used to produce an aerosol of droplets for inhalation through the mouth and pharyngeal cavity into the lungs of a patient, for nasal administration, or for spraying the surface of the eye.
  • SIs soft mist inhalers
  • liquid pharmaceutical formulations are typically stored in a reservoir. From there, they are conveyed through a riser tube into a pressure chamber from where they are forced through a nozzle under pressure and atomised.
  • drug delivery devices such as SMIs are able to nebulise a small amount of a liquid formulation according to the required dosage within a few seconds to produce an aerosol suitable for therapeutic inhalation. Moreover, this can be achieved without requiring the use of a propellant.
  • the nozzle is typically held in place in the device by a fixing mechanism and/or structure.
  • a small amount of the liquid may be deposited as a film or as an accumulation of small droplets on the surface of the nozzle and/or the fixing means. It has been found that the deposited liquid can disrupt the flow of further liquid through the nozzle, which can affect the pharmaceutical quality of the aerosol mist.
  • the present invention may broadly be said to consist in a nozzle arrangement for delivering a liquid from a liquid delivery device, comprising: a nozzle holder configured to form a nozzle, the nozzle having an inlet side at or towards the narrower end for receiving a liquid to be delivered and an outlet side at or towards the wider for delivering the liquid; a fixing device configured to in use fix the nozzle holder in the delivery device; and at least one recess located at or near the outlet side of the nozzle, wherein the recess is configured to wick away liquid deposited on the nozzle and/or fixing device.
  • the nozzle holder and the fixing device are mutually configured so that the at least one recess is formed and located between the fixing device and the nozzle.
  • the at least one recess is formed so as to run substantially around the entirety of the perimeter of the nozzle holder.
  • the at least one recess is formed as multiple recesses around the perimeter of the nozzle holder.
  • a first recess and a second recess are formed/arranged between the nozzle holder and the fixing device, each of the recesses having a length that extends about 3/8 of the way around the circumference of the nozzle, so that the recesses form two separate partial ring segments separated at each end by about 1/8 of the circumference of the nozzle.
  • the at least one recess is square or rectangular in cross section.
  • the at least one recess has a depth extending substantially in parallel with the depth of the nozzle.
  • the at least one recess is aligned so that the open end of the recess faces in substantially the same direction as the nozzle outlet side.
  • the depth of the at least one recess is less than the depth of the nozzle.
  • the at least one recess has a depth extending substantially perpendicular to the depth of the nozzle.
  • the at least one recess opens inwards towards the nozzle.
  • the nozzle holder and the fixing device are mutually configured so that the recess narrows with depth.
  • the recess is triangular or trapezoidal in cross-section.
  • the recess is chamfered or curved.
  • the recess has a depth that extends away from the opening of the recess in a direction generally parallel to the cylindrical axis of the nozzle, the recess gradually curving away such that at the lowermost end the recess extends generally perpendicular to the cylindrical axis of the nozzle.
  • the opening width of the recess is substantially between 0.1 mm and 5mm, and most preferably substantially between 0.1 mm and 1 mm.
  • the depth of the recess is substantially between 0.5mm and 10mm, and most preferably substantially between 0.5mm and 5mm.
  • the fixing device comprises a nut.
  • the present invention may broadly be said to consist in a liquid delivery device comprising a nozzle arrangement according to any one of the preceding statements.
  • the liquid delivery device comprises an inhaler for nebulising pharmaceutical liquids.
  • the liquid delivery device comprises a soft mist inhaler (SMI).
  • SI soft mist inhaler
  • This invention may also be said broadly to consist in the parts, elements and features referred to or indicated in the specification of the application, individually or collectively, and any or all combinations of any two or more said parts, elements or features, and where specific integers are mentioned herein which have known equivalents in the art to which this invention relates, such known equivalents are deemed to be incorporated herein as if individually set forth.
  • Figure 1 A shows a cross-sectional side view of a nozzle arrangement in accordance with a first embodiment of the invention, the nozzle arrangement having a nozzle which has an inlet side for receiving a liquid to be delivered and an outlet side for delivering the liquid, and a recess located at or near the outlet side of the nozzle, the recess arranged to wick away liquid deposited on the nozzle.
  • Figure 1 B shows a cross-sectional view of the nozzle arrangement of Figure 1 A from the same angle as Figure 1 A, with the recess highlighted.
  • Figure 2 shows a perspective cross-sectional side view of the nozzle arrangement of Figures 1 A and 1 B in use with and forming part of a liquid delivery device.
  • Figure 3 shows a perspective view from the same angle as Figure 2 of the nozzle arrangement of Figure 1 A and Figure 1 B in use with and forming part of a liquid delivery device.
  • Figure 4 shows a top view of the nozzle arrangement of any one of the preceding figures with the recess highlighted.
  • Figure 5 shows a top view of a nozzle arrangement in accordance with a second embodiment of the invention, the nozzle arrangement similar to that shown in Figures 1 A to 4, the nozzle arrangement in this embodiment having first and second recesses, each of the recesses having a length that extends about 3/8 of the way round the circumference of the nozzle, so that the recesses form two separate partial ring segments separated at each end by about 1/8 of the circumference of the nozzle.
  • Figure 6 shows a cross-sectional side view of a nozzle arrangement in accordance with a third embodiment of the invention.
  • Figure 7 shows a cross-sectional side view of a nozzle arrangement in accordance with a fourth embodiment of the invention.
  • Figure 8 shows a cross-sectional side view of a nozzle arrangement in accordance with a fifth embodiment of the invention.
  • a nozzle arrangement 100 in accordance with a first embodiment of the invention comprises the following main parts: a nozzle holder 110; a nozzle chip 107; a nut 120, and; an annular seal 111.
  • This embodiment is shown in figures 1 A, 1 B, 2, 3, and 4.
  • the nozzle holder 110 is configured so that one side of the holder 110 is nozzle-shaped. That is, it forms a nozzle - nozzle 102 - that has the form of a conical-shaped recess 108 in one end of the nozzle holder 110.
  • the nozzle 102 has an inlet side 104 (at the narrower end of the conical-shaped recess 108) for receiving a liquid to be delivered, and an outlet side 106 (the wider end of the conical shaped recess 108) for delivering the liquid.
  • An aperture 112 is formed at the narrower end of the conical-shaped recess 108.
  • the nozzle chip 107 is configured to locate in use on the inlet side 104 next to the aperture 112.
  • the central aperture 112 is configured to allow a flow of liquid from the nozzle chip 107 to exit the nozzle arrangement 100 through the nozzle holder 110, from the inlet side 104 to the outlet side 106.
  • a “nozzle chip” as defined herein is a component having an inlet end and an outlet end connected by a plurality of microstructured channels.
  • the inlet end of the nozzle chip comprises a filtering structure, comprising one or more microstructured channels that are generally zig-zag shaped (i.e. form a generally zig-zag structure). In this way, the filtering structure advantageously prevents any coarse debris from blocking the microstructured channels at the outlet end.
  • the outlet end of the nozzle chip comprises one or more spray jets. If a nozzle chip is used that has two or more spray jets are present, the geometries of the spray jets can be arranged to cause two or more jets of liquid exiting the spray jets to impinge upon one another (i.e. collide with each other).
  • the nut 120 is configured for fixing the nozzle holder 110 in place in, and as part of, a larger delivery device (not shown).
  • the nut 120 in this embodiment substantially surrounds and encloses the nozzle holder 110.
  • the nozzle holder 110 and nut 120 are mutually configured so that in use a recess 130 is formed between the nozzle holder 110 and the nut 120, at each side of the nozzle holder 110.
  • the nozzle holder 110 and the nut 120 are configured so that the recess 130 appears rectangular in cross-sectional side view (e.g. the view shown in figures 1 A and 1 B) at either side of the nozzle holder.
  • the recess 130 is highlighted as a shaded area in Figure 1 B.
  • the recess 130 extends circumferentially around the nozzle 102 to form a continuous loop (i.e. ring) in plan view.
  • the recess 130 has a depth - that is, the dimension that extends generally parallel to the cylindrical axis or axis of rotation of the nozzle holder 110 and nozzle 120. In this embodiment, the depth is less than the depth of the nozzle 102.
  • the recess is open-topped - that is, it is open in the same direction as the outlet side 106.
  • the annular elastomeric seal 111 surrounds the nozzle chip 107, around the perimeter of the nozzle chip 107, between the nozzle chip 107 and the nozzle holder 110.
  • liquid is forced under pressure through the nozzle chip 107 from that side of the nozzle chip 107 opposite the aperture 112, through the chip 107 to the aperture 112, and then out through the aperture 112 from the inlet side 104 to the outlet side 106.
  • the liquid exits the aperture 112 it is atomised to form an aerosol mist, which is directed away from the aperture 112 through the conical-shaped recess 108.
  • a small amount of the liquid can be deposited on the surfaces of the conical-shaped recess 108, the nozzle holder 110 and/or the nut 120, on the outlet side 106.
  • This deposition can for example be in the form of an accumulation of small droplets.
  • the deposited liquid is wicked away by the recess 130, the liquid entering the recess 130 at the open top or open end, and then moving through the recess 130 for example via capillary action .
  • Figure 5 shows a top view of a nozzle arrangement 200 in accordance with a second embodiment of the invention.
  • the nozzle arrangement 200 in this embodiment is similar to the nozzle arrangement of the first embodiment of the invention, and comprises broadly similar elements to those of the first embodiment. Similar numbering is used for this embodiment as for the first embodiment - e.g. nozzle holder 210 in this embodiment is equivalent to nozzle holder 110 in the first embodiment, nozzle chip 207 to nozzle chip 107, nut 220 to nut 120, etc.
  • the nozzle arrangement 200 has substantially the same elements and structure as for the first embodiment, except that the nozzle holder 210 and the nut 220 are configured so that two recesses - a first recess 230 and a second recess 232 - are formed/arranged therebetween.
  • each of the recesses 230, 232 is rectangular in cross-section (as for the first embodiment).
  • each of the recesses 230 and 232 has a length that extends about 3/8 of the way round the circumference of the nozzle 202, so that the recesses 230, 232 form two separate partial ring segments separated at each end by about 1/8 of the circumference of the nozzle 202.
  • Each of the recesses 230, 232 has a depth that extends generally parallel to the cylindrical axis of the nozzle 220. As for the first embodiment, the depth is less than the depth of the nozzle 202.
  • a nozzle arrangement 300 in accordance with a third embodiment of the invention is shown in Figure 6.
  • the nozzle arrangement 300 in this embodiment comprises: a nozzle holder 310; a nozzle chip 307; a nut 320, and; an annular seal 311 (with similar numbering used for similar/equivalent parts, as for the first and second embodiments).
  • a recess 330 is arranged between the nozzle holder 310 and the nut 320. This has the same or a similar function to the recesses described for the other embodiments, and works in a similar manner.
  • the recess 330 is rectangular in cross-section, and has a length that extends the whole way round the circumference of the nozzle 302 to form a continuous loop (i.e. ring).
  • the recess 330 has a depth that extends generally orthogonal to the cylindrical axis of the nozzle 302, as shown in Figure 6, in which the recess 330 is highlighted as a shaded area.
  • a nozzle arrangement 400 in accordance with a fourth embodiment of the invention is shown in figure 7.
  • the nozzle arrangement 400 in this embodiment has similar elements to the preceding embodiment, and equivalent numbering is used for equivalent elements.
  • a recess 430 is arranged between the nozzle holder 410 and the nut 420.
  • the recess 430 is triangular (i.e. wedge shaped) in cross-section, and has a length that extends the whole way round the circumference of the nozzle 402 to form a continuous loop (i.e. ring).
  • the recess 430 has a depth that extends generally orthogonal to the cylindrical axis of the nozzle 402, as shown in Figure 7, in which the recess 430 is highlighted as a shaded area.
  • a nozzle arrangement 500 in accordance with a fifth embodiment of the invention is shown in figure 8.
  • the nozzle arrangement 500 in this embodiment has similar elements to the preceding embodiments, and equivalent numbering is used for equivalent elements.
  • a recess 530 is arranged between the nozzle holder 510 and the nut 520.
  • the recess 530 is curved in cross-section, and has a length that extends the whole way round the circumference of the nozzle 502 to form a continuous loop (i.e. ring).
  • the recess 530 has a depth that extends away from the opening of the recess 520 in a direction generally parallel to the cylindrical axis of the nozzle 502, the recess 530 gradually curving away such that at the lowermost end (the bottom end) the recess 530 extends generally perpendicular to the cylindrical axis of the nozzle 502.
  • the width or opening of the recess is in a range of from 0.1 mm to 5 mm, but the best results are achieved in a range of between 0.1 mm to 1 mm.
  • the overall depth or length of the recess is in a range of from 0.5mm to 10mm, with the best results achieved in a range of 0.5mm to 5mm.
  • the recess helps to control liquid deposition on the outlet side of the nozzle and/or the fixing device by pulling any deposited liquid droplets away. This reduces the amount of dispensed liquid deposited on the nozzle and/or the fixing device and helps to minimise or prevent disruption of the flow of further liquid through the nozzle. This allows for greater consistency of drug delivery from a delivery device through improved retained droplet control.
  • the recess wicks away liquid deposited on the nozzle and/or fixing device by capillary action. In this way, the recess helps to control liquid deposition on the outlet side of the nozzle and/or the fixing device by drawing any deposited liquid droplets away by capillary action.
  • the nozzle arrangement is particularly suitable for delivering a liquid from a inhaler.
  • the liquid may be a pharmaceutical liquid.
  • pharmaceutical liquid refers to a solution, emulsion, or suspension of one or more active pharmaceutical ingredients in a suitable solvent.
  • the inhaler may, for example, be a soft mist inhaler (SMI).
  • the liquid delivery device may be an inhaler for nebulising pharmaceutical liquids.
  • the liquid delivery device may suitably be a soft mist inhaler (SMI).
  • Suitable materials for the nozzle and/or fixing device may include, but are not limited to, polyether ether ketone (PEEK), stainless steel and/or polyoxymethylene (POM).
  • a Malvern Panalytical (RTM) Spraytec (TM) laser diffraction system was used to observe the droplet diameters over a number of actuations (i.e. spay events) for a delivery device comprising a nozzle arrangement in accordance with the first embodiment of the invention, but with the recess (recess 130) filled in (i.e. blocked).
  • a high average Dv90 was observed, along with a high variability in the droplet size.
  • the Dv90 value indicates that 90% of the spray volume is contained in droplets that are smaller than the Dv90 value, and 10% is contained in droplets that are larger than the Dv90 value.
  • the high average Dv90 was attributed to droplets forming on the nozzle and running back into the path of the central aperture of the nozzle holder and disrupting the spray formed by the nozzle chip.
  • a Malvern Panalytical (RTM) Spraytec (TM) laser diffraction system was used to observe the droplet diameters over a number of actuations (i.e. spay events) for a delivery device comprising a nozzle arrangement 100 as described above for the first embodiment. That is, the same nozzle arrangement used in the comparative/control example above. However, in this example the wicking recess was not filled in (i.e. blocked)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nozzles (AREA)

Abstract

Un agencement de buse 100 pour distribuer un liquide à partir d'un dispositif de distribution de liquide comprend un support de buse 110 conçu pour former une buse 102, la buse 102 ayant un côté d'entrée 104 au niveau ou vers l'extrémité plus étroite pour recevoir un liquide à distribuer et un côté de sortie 106 au niveau ou vers le plus large pour distribuer le liquide; un dispositif de fixation 120 conçu pour, lors de l'utilisation, fixer le support de buse 110 dans le dispositif de distribution; et au moins un évidement 130 situé au niveau ou à proximité du côté de sortie 106 de la buse 102, l'évidement 130 étant conçu pour évacuer le liquide déposé sur la buse 102 et/ou le dispositif de fixation 120.
PCT/IB2023/055019 2022-05-16 2023-05-16 Agencement de buse Ceased WO2023223196A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP23730903.4A EP4514434A1 (fr) 2022-05-16 2023-05-16 Agencement de buse

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17/745,357 US20230364360A1 (en) 2022-05-16 2022-05-16 Nozzle Arrangement
US17/745,357 2022-05-16
GB2207090.8 2022-05-16
GB2207090.8A GB2618785B (en) 2022-05-16 2022-05-16 Nozzle arrangement

Publications (1)

Publication Number Publication Date
WO2023223196A1 true WO2023223196A1 (fr) 2023-11-23

Family

ID=86771297

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2023/055019 Ceased WO2023223196A1 (fr) 2022-05-16 2023-05-16 Agencement de buse

Country Status (2)

Country Link
EP (1) EP4514434A1 (fr)
WO (1) WO2023223196A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005065294A2 (fr) * 2003-12-30 2005-07-21 Dimatix, Inc. Dispositif d'ejection de gouttes
US20090147049A1 (en) * 2007-12-11 2009-06-11 Samsung Electronics Co., Ltd. Nozzle plate of inkjet printhead and method of manufacturing the same
CA2552535C (fr) * 2004-01-08 2014-05-27 Boehringer Ingelheim International Gmbh Dispositif pour fixer un composant fluidique
US20160199868A1 (en) * 2013-09-09 2016-07-14 Musashi Engineering, Inc. Nozzle and liquid material discharge device provided with said nozzle
US20210093802A1 (en) * 2018-03-21 2021-04-01 Softhale Nv Spray nozzle for an inhalation device

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005065294A2 (fr) * 2003-12-30 2005-07-21 Dimatix, Inc. Dispositif d'ejection de gouttes
CA2552535C (fr) * 2004-01-08 2014-05-27 Boehringer Ingelheim International Gmbh Dispositif pour fixer un composant fluidique
US20090147049A1 (en) * 2007-12-11 2009-06-11 Samsung Electronics Co., Ltd. Nozzle plate of inkjet printhead and method of manufacturing the same
US20160199868A1 (en) * 2013-09-09 2016-07-14 Musashi Engineering, Inc. Nozzle and liquid material discharge device provided with said nozzle
US20210093802A1 (en) * 2018-03-21 2021-04-01 Softhale Nv Spray nozzle for an inhalation device

Also Published As

Publication number Publication date
EP4514434A1 (fr) 2025-03-05

Similar Documents

Publication Publication Date Title
RU2717226C1 (ru) Микроструктурированная форсунка
JP6514277B2 (ja) 吸入用装置及び吸入用装置のための混合流路
US7284713B2 (en) System comprising a nozzle and a fixing means therefor
CZ94198A3 (cs) Sestava rozprašovací trysky, rozprašovací tryska a způsob vytváření dýchatelného spreje
CN101636232A (zh) 基于喷嘴的雾化系统
GB2618785A (en) Nozzle arrangement
WO2023223196A1 (fr) Agencement de buse
US20230364360A1 (en) Nozzle Arrangement
RU2755024C2 (ru) Сопло для различных жидкостей
CN103079618B (zh) 定量吸入器致动器、定量吸入器
CN119212752B (zh) 用于药物输送装置的吸嘴固定组件
WO2003047763A1 (fr) Nebuliseur modifie
KR20100134732A (ko) 토출 헤드 카트리지 및 토출 헤드 카트리지를 설치 가능한 흡입 장치
CN209713890U (zh) 微结构喷嘴
CN110433361B (zh) 微结构喷嘴
US20230364356A1 (en) Fixing Assembly
WO2019210515A1 (fr) Buse microstructurée
TWI761510B (zh) 微結構通路模組及應用其之氣霧化器
JP2025539897A (ja) 微小構造ノズル
GB2621810A (en) Fixing assembly
GB2640621A (en) A nozzle retainer

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 23730903

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2023730903

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2023730903

Country of ref document: EP

Effective date: 20241128

NENP Non-entry into the national phase

Ref country code: DE