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WO2023273206A1 - Liquide à base de peptides du type astaxanthine-collagène pour administration par voie orale et son procédé de préparation - Google Patents

Liquide à base de peptides du type astaxanthine-collagène pour administration par voie orale et son procédé de préparation Download PDF

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Publication number
WO2023273206A1
WO2023273206A1 PCT/CN2021/138746 CN2021138746W WO2023273206A1 WO 2023273206 A1 WO2023273206 A1 WO 2023273206A1 CN 2021138746 W CN2021138746 W CN 2021138746W WO 2023273206 A1 WO2023273206 A1 WO 2023273206A1
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WIPO (PCT)
Prior art keywords
astaxanthin
collagen
preparation
solution
collagen peptide
Prior art date
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Ceased
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PCT/CN2021/138746
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English (en)
Chinese (zh)
Inventor
赵子方
郭红星
周尽学
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Hainan San Yuan Xing Biotechnology Co Ltd
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Hainan San Yuan Xing Biotechnology Co Ltd
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Publication of WO2023273206A1 publication Critical patent/WO2023273206A1/fr
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Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/04—Animal proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the invention relates to the technical field of health products, in particular to an astaxanthin-collagen peptide oral liquid and a preparation method thereof.
  • Astaxanthin also known as astaxanthin and lobster shell pigment, is a carotenoid and the highest grade product of carotenoid synthesis. It is dark pink in color and has a chemical structure similar to ⁇ -carotene. ⁇ -carotene, lutein, canthaxanthin, lycopene, etc. are all intermediate products of carotenoid synthesis, so in nature, astaxanthin has the strongest antioxidant activity. Widely present in the biological world, especially in the feathers of shrimp, crab, fish, algae, yeast and birds. It is one of the main carotenoids in marine organisms. The antioxidant capacity of astaxanthin is ⁇ - It is 10 times of carotene and 500 times of vitamin E. It is called "super vitamin E".
  • Collagen is a biological Macromolecule, the main component of animal connective tissue, is also the most abundant and widely distributed functional protein in mammals, accounting for 25% to 30% of the total protein, and even as high as 80% in some organisms.
  • Livestock and poultry-derived animal tissues are the main way for people to obtain natural collagen and its collagen peptides.
  • EFSA European Food Safety Authority
  • it is derived from marine animals. Collagen from terrestrial animals is obviously superior to collagen from terrestrial animals in some respects, such as low antigenicity and hypoallergenic properties.
  • aquatic collagen may gradually replace terrestrial animal collagen.
  • collagen There are many types of collagen, and the common types are type I, type II, type III, type V and type XI.
  • Collagen has been widely used in food, medicine, tissue engineering, cosmetics and other fields due to its good biocompatibility, biodegradability and biological activity.
  • Skin photoaging in life is the cumulative damage caused by long-term exposure to ultraviolet radiation on the skin. Excessive ultraviolet radiation will degrade skin collagen, hyaluronic acid and elastin, resulting in severe changes in skin appearance, which can lead to basal cell carcinoma and melanoma and the formation of neoplastic diseases such as squamous cell carcinoma.
  • the present invention provides an astaxanthin-collagen peptide oral liquid and a preparation method thereof, which solves the problem of promoting skin cell proliferation while retaining all or part of the anti-skin photoaging activity of astaxanthin, effectively improving the following Instability is the representative defect of astaxanthin application.
  • the invention provides a preparation method of the astaxanthin-collagen peptide composition, comprising the following steps:
  • Step 1 After taking Haematococcus pluvialis powder and mixing it with an organic solvent, heating and extracting to obtain an extract;
  • Step 2 taking the extract obtained in step 1 and centrifuging to collect the supernatant, and saponifying the supernatant to obtain a saponification solution;
  • Step 3 extracting the saponification solution prepared in step 2 to obtain astaxanthin;
  • Step 4 Preheat and filter the collagen to obtain collagen peptides
  • Step 5 Mix the astaxanthin prepared in step 3 with the collagen peptide prepared in step 4 to prepare an astaxanthin-collagen peptide composition.
  • the organic solvent in step 1 includes ethyl acetate, the heating temperature is 50° C., and the extraction time is 100 min.
  • the centrifugation described in step 2 is: centrifugation at 5°C and 400r/min; for 20min.
  • the extraction described in step 3 is eluted with n-hexane to obtain astaxanthin.
  • the preheating temperature in step 4 is 37° C.
  • the filtration includes secondary filtration
  • the first filtration uses a 0.45um filter membrane.
  • the present invention also provides the astaxanthin-collagen peptide composition prepared by the preparation method.
  • the present invention also provides an astaxanthin-collagen peptide oral liquid, including the astaxanthin-collagen peptide composition and additives prepared by the preparation method.
  • the present invention also provides a method for preparing the astaxanthin-collagen peptide oral liquid, mixing the astaxanthin-collagen peptide composition prepared by the preparation method with additives, heating and stirring to obtain shrimp Penicillin-Collagen Peptide Oral Solution.
  • the additive includes one of acetic acid, water, glycerin, stearic acid, cetyl alcohol, lanolin, paraffin oil, glyceryl monostearate, sodium lauryl sulfate one or more combinations.
  • the additive includes acetic acid and water, the pH of the mixture is 5.0, the stirring speed is 200rpm, and the stirring time is 2h; or the additive includes water, glycerin , stearic acid, cetyl alcohol, lanolin, paraffin oil, glyceryl monostearate, sodium lauryl sulfate; mix astaxanthin with collagen peptide, add stearic acid 10%, cetyl alcohol 15%, lanolin 1%, paraffin oil 5%; emulsifier: glyceryl monostearate 4%, sodium lauryl sulfate 1.5%; water phase: glycerin 3%, deionized water 74%; Good oil phase, emulsifier and water phase, the oil phase and emulsifier are homogeneously stirred at 75° for 15-20min.
  • the invention provides an astaxanthin-collagen peptide oral liquid and a preparation method thereof. Including but not limited to the following beneficial effects:
  • the present invention improves the quality of extracted astaxanthin by processing Haematococcus pluvialls powder to extract the required astaxanthin, and extracts and modifies the extracted astaxanthin, and makes astaxanthin into a solution , convenient for recycling and processing, and more convenient to carry. Afterwards, the concentration of the extracted astaxanthin is tested to ensure the quality of the product. Afterwards, the product is placed in a light-proof freezing environment to improve the preservation of the product, and it can pass through human cells.
  • the outer wall directly removes oxygen free radicals in cells, enhances cell regeneration, maintains the balance of human body functions, reduces the accumulation of aging cells, and protects the health of cells and DNA from the inside out.
  • the present invention improves the quality of the required product by extracting the collagen and filtering the extracted solution in multiple layers.
  • the processed collagen is actively absorbed by the human body and can be fully absorbed by body tissues. Regular consumption of collagen peptides can stabilize calcium in the body, strengthen bones, make skin more elastic, delay aging, improve immunity, improve sleep status, etc.
  • the product can be taken orally by fusing and stirring astaxanthin and collagen, and when the collagen whitens, moisturizes, and repairs the user's skin, the fusion of astaxanthin and collagen can Preserves astaxanthin's anti-skin smoothing and aging properties without compromising the effects of collagen.
  • Fig. 1 shows the schematic flow chart of the present invention.
  • the invention discloses an astaxanthin-collagen peptide oral liquid and a preparation method thereof, and those skilled in the art can learn from the content of this article and appropriately improve the process parameters to realize it.
  • all similar replacements and modifications are obvious to those skilled in the art, and they are all considered to be included in the present invention.
  • the method and application of the present invention have been described through preferred embodiments, and the relevant personnel can obviously make changes or appropriate changes and combinations to the method and application described herein without departing from the content, spirit and scope of the present invention to realize and Apply the technology of the present invention.
  • an astaxanthin-collagen peptide oral liquid and a preparation method thereof comprising the following steps:
  • Extraction of astaxanthin the astaxanthin is extracted by preparing Haematococcus pluvialls powder in advance, weighing the required weight of the prepared Haematococcus pluvialls powder, adding raw materials, heating and carrying out Stir, and extract the solution after stirring for a certain period of time;
  • solution modification the solution modification is to take out the clear liquid above the solution by centrifuging the extracted solution at low temperature, perform saponification reaction on the clear liquid, and control the concentration, temperature and time of the raw materials added in the saponification reaction;
  • Sp3 Solution qualification confirmation: The qualification confirmation of the solution needs to extract the processed astaxanthin, conduct a qualification comparison of the product according to the astaxanthin standard product, and properly store the product after passing it;
  • Sp5 Mixed product: the mixed product mixes the preserved astaxanthin with the processed collagen and adds an appropriate proportion of additives for mixing;
  • Sp6 stirring and collecting: the stirring and collecting is to uniformly heat and stir the mixed solution, and extract and cool down the stirred solution for storage;
  • the added raw material of the Haematococcus pluvialis powder is acetic acid ethanol
  • the temperature after heating and stirring the Haematococcus pluvialls powder after adding acetic acid ethanol is 50 degrees
  • the time for stirring and extracting is 100 minutes.
  • the saponification reaction is carried out with an alkali, and the concentration of the alkali is 0.4 mpl/L, and the reaction time is 20 minutes, and the reaction temperature is 20 degrees.
  • the astaxanthin after the saponification reaction is extracted for elution, and the eluent is n-hexane liquid, the purity of the astaxanthin standard is ⁇ 97%, and the purity is qualified and protected from light Store frozen.
  • the preheating temperature of the collagen is 37°C.
  • the collagen was filtered twice, and the first filtration was performed with a 0.45um filter membrane, and the second filtration was performed with a membrane bag with a molecular weight cut-off of kDa.
  • the additive added by mixing the astaxanthin with the processed collagen is dissolved in acetic acid and water, and the pH is adjusted to 5.0 by dissolving the acetic acid and water.
  • the stirrer for stirring and mixing solution adopts a centrifugal stirring device, and the rotating speed of the stirring device is 200rpm, and the stirring time is 2h, and the collection environment should be a low-temperature and light-proof environment.
  • stearic acid 15% cetyl alcohol, 1% lanolin, and 5% paraffin oil
  • emulsifier glyceryl monostearate 4 %, sodium lauryl sulfate 1.5%
  • water phase glycerin 3%, deionized water 74%.
  • oil phase, emulsifier and water phase in proportion, and stir the oil phase and emulsifier homogeneously at 75° for 15-20min.
  • used raw materials and reagents can be purchased from the market.
  • the embodiment of the present invention provides an astaxanthin-collagen peptide oral liquid and a preparation method thereof, comprising the following steps:
  • Astaxanthin is extracted by preparing Haematococcus pluvialls powder in advance, weighing the required weight of the prepared Haematococcus pluvialls powder, adding ethyl acetate, heating and stirring at 50°C , to obtain the extraction solution after stirring for 100 min;
  • solution modification is to take out the clear liquid above the solution by centrifuging the extracted solution at a low temperature (not higher than 5°C) (400r/min), and perform saponification reaction on the clear liquid.
  • the saponification reaction uses alkali to react,
  • the concentration of alkali can be sodium hydroxide) is 0.4mpl/L, the time of reaction is 20min, and the temperature of reaction is 20 degrees;
  • the processed astaxanthin needs to be extracted and eluted with n-hexane to obtain astaxanthin.
  • the purity of the astaxanthin standard product is ⁇ 97%, and the product is qualified according to the astaxanthin standard product. , after the product is qualified, it should be stored reasonably;
  • Collagen Processing and Extraction Preheat the collagen solution at 37°C through the prepared collagen solution in advance, and filter the preheated collagen solution; filter twice, and filter for the first time A 0.45um filter membrane is used for filtration, and a membrane bag with a molecular weight cut-off of kDa is used for the second filter for the second filter;
  • Sp5 Mixed product: Mixed product mix preserved astaxanthin with processed collagen and add appropriate proportion of additives for mixing;
  • the required astaxanthin is extracted by processing the Haematococcus pluvialis powder, and the extracted astaxanthin is extracted and modified, which improves the quality of the extracted astaxanthin, and makes the astaxanthin into a solution, which is convenient for recycling and processing. Processing and carrying are more convenient, and then the concentration of the extracted astaxanthin is detected to ensure the quality of the product, and then the product is placed in a light-proof freezing environment to improve the preservation of the product, which can pass through the outer wall of human cells and directly remove the intracellular Oxygen free radicals can enhance cell regeneration, maintain the balance of human body functions and reduce the accumulation of aging cells, protecting the health of cells and DNA from the inside out.
  • the collagen is extracted and the extracted solution is filtered through multiple layers, which improves the quality of the required product.
  • the processed collagen is actively absorbed by the human body and can be fully absorbed by body tissues. Regular consumption of collagen peptides can stabilize calcium in the body, strengthen bones, make skin more elastic, delay aging, improve immunity, improve sleep status, etc.
  • Astaxanthin and the processed collagen are mixed with acetic acid and water as additives, and the acetic acid and water are dissolved to adjust the pH to 5.0.
  • the agitator of the mixed solution adopts a centrifugal stirring device with a rotating speed of 200 rpm and a stirring time of 2 hours.
  • the collection environment should be low temperature and light-proof environment.
  • the oil phase, emulsifier and water phase are prepared in proportion, the oil phase and emulsifier are homogeneously stirred at 75° for 15-20min, and astaxanthin and collagen are mixed and stirred, the product can be taken orally, and in the collagen
  • astaxanthin is fused with collagen to retain astaxanthin's anti-skin smoothness and aging properties without compromising the effect of collagen.

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un liquide à base de peptides du type astaxanthine-collagène pour administration par voie orale et son procédé de préparation. Le procédé de préparation consiste : à effectuer une extraction de l'astaxanthine : par préparation d'une poudre d'Haematococcus pluvialis à l'avance, pesée du poids requis de la poudre d'Haematococcus pluvialis ainsi préparée, ajout de matières premières, chauffage et agitation des matières premières, et extraction d'une solution après agitation pendant une certaine durée ; à effectuer une modification de la solution pour extraire un liquide transparent sur la solution, et à effectuer une réaction de saponification sur le liquide transparent ; à préchauffer une solution de collagène, et à filtrer la solution de collagène préchauffée ; à effectuer un mélange de produits : par mélange de l'astaxanthine stockée et du collagène transformé, et ajout d'un additif en vue d'un mélange ; et à effectuer une agitation et un recueil : par chauffage uniforme et agitation de la solution mélangée, et extraction, refroidissement et stockage de la solution agitée. L'astaxanthine est fusionnée avec le collagène, de façon à pouvoir conserver la douceur de la peau et la résistance au vieillissement de l'astaxanthine à condition que l'effet du collagène ne soit pas altéré.
PCT/CN2021/138746 2021-07-01 2021-12-16 Liquide à base de peptides du type astaxanthine-collagène pour administration par voie orale et son procédé de préparation Ceased WO2023273206A1 (fr)

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Cited By (1)

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CN116173190A (zh) * 2023-03-06 2023-05-30 北京理工大学重庆创新中心 一种胶原蛋白载体、胶原蛋白纳米粒及其制备方法和应用

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CN113349373A (zh) * 2021-07-01 2021-09-07 海南三元星生物科技股份有限公司 虾青素-胶原蛋白肽口服液及其制备方法
CN114392350A (zh) * 2022-01-25 2022-04-26 浙江瘦金体健康管理集团有限公司 一种透明质酸口服液及其制备方法
CN116491615B (zh) * 2023-05-17 2023-09-12 哈尔滨三联药业股份有限公司 美藤果油胶原蛋白肽饮料组合物及其制备方法

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