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WO2023127975A1 - Dispositif de chauffage de cornées - Google Patents

Dispositif de chauffage de cornées Download PDF

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Publication number
WO2023127975A1
WO2023127975A1 PCT/JP2022/048711 JP2022048711W WO2023127975A1 WO 2023127975 A1 WO2023127975 A1 WO 2023127975A1 JP 2022048711 W JP2022048711 W JP 2022048711W WO 2023127975 A1 WO2023127975 A1 WO 2023127975A1
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WO
WIPO (PCT)
Prior art keywords
cornea
heating element
corneal
spectacles
warming
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2022/048711
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English (en)
Japanese (ja)
Inventor
一男 坪田
眞一郎 近藤
靖恵 満倉
映輔 清水
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Tsubota Laboratory Inc
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Tsubota Laboratory Inc
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Publication date
Application filed by Tsubota Laboratory Inc filed Critical Tsubota Laboratory Inc
Priority to JP2023571237A priority Critical patent/JPWO2023127975A1/ja
Publication of WO2023127975A1 publication Critical patent/WO2023127975A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/02—Goggles
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C11/00—Non-optical adjuncts; Attachment thereof

Definitions

  • the present invention relates to a device for warming the cornea. More specifically, by delivering heat directly and effectively to the cornea with directional heat radiation safely without obstructing vision (especially the field of vision), the cornea is warmed and pain is relieved.
  • the present invention relates to a device (corneal warming device) for improving or treating dry eye.
  • Patent Literatures 1 and 2 propose spectacles with an anti-fogging function.
  • the spectacles of Patent Document 1 are intended to prevent fogging that occurs when the temperature and humidity change due to movement from outdoors to indoors.
  • the spectacles of Patent Document 2 are protective spectacle fogging prevention systems that effectively prevent protective spectacles from fogging regardless of weather conditions, and have a heating system including a heating element, a heating control circuit, and the like.
  • Patent Documents 3 and 4 propose spectacle-type devices for improving dry eyes.
  • the therapeutic covering of U.S. Patent No. 5,200,000 has heating means and means for saturating the air contained against the face with water vapor to prevent evaporation from the eyes and eyelids and to transfer heat to the covered tissue. It enhances transmission and is designed to prevent condensation and maintain clear vision at all times when in use.
  • the spraying device of Patent Document 4 is a device for supplying at least a minute liquid, and includes a spraying element for spraying a mist containing the minute liquid to a local area, and a mist containing at least the minute liquid sprayed by the atomizing element. It has a heating element that heats an object, and supplies at least minute liquid to the eye, and is said to be used for relief of dry eye symptoms, drug delivery, allergy prevention, relaxation, and the like.
  • Patent Document 5 proposes thermal spectacles in which heat can be easily controlled and treatment can be easily performed with the eyes open.
  • These warming spectacles consist of a cover holding a warming device capable of raising the temperature of the eyelids and eyes on the inner surface, and a means for holding the colored spectacle lenses with this cover attached to the position of the eyes so that they can be brought into close contact with each other. It is a configuration with Since the heating spectacles are ring-shaped, they heat only the eyelid portion, which is advantageous in that they hardly affect the cornea and the eyeball (paragraphs 0038 and 0039 of the same document).
  • JP-A-3-27014 JP 2017-40930 A Japanese Patent Publication No. 2005-515026 WO2018/221687 JP-A-11-221247
  • the inventor considered warming the eyes in the process of conducting research on the eyes.
  • the cause of discomfort such as increased blinking is related to the effect of pain receptors in the cornea. I got the knowledge that it is possible to achieve a pleasant feeling.
  • the inventors have found that direct heating of only the cornea is effective in improving and treating symptoms of dry eye. For that purpose, it is necessary to warm the cornea appropriately.
  • Patent Documents 1 to 4 are intended to prevent fogging and improve dry eyes, and have a heating element that evaporates water to control the humidity in the vicinity of the eye. The element is for evaporating water to increase or decrease humidity, and cannot directly heat the cornea.
  • the technique proposed in Patent Document 5 warms only the eyelid portion without affecting the cornea or the eyeball, and cannot directly warm the cornea.
  • the present invention proposes a new technique for directly warming the cornea, instead of warming the area around the eyes or the entire eye as proposed in the prior art, and the purpose thereof is to not impede vision (especially the field of view).
  • An object of the present invention is to provide a device (hereinafter also referred to as a "corneal warming device").
  • a corneal warming device is a device in which a heating element warms the cornea to relieve pain and/or improve dry eye, wherein the heating element comprises a resistance heating element, One or two or more selected from a resistance heating element, a heat conductor, and an infrared radiation element, and the heating element is positioned below the front surface of each of the corneas, a position laterally from the lower front surface of each of the corneas, or the It is characterized in that it is arranged at a position on each side of the cornea at a distance of 10 mm or more and 60 mm or less from the cornea.
  • the heating element has an element for warming the cornea to relieve pain and/or improve dry eye
  • the heating element is a resistance heating element, a resistance heating element and a heat conductor, and an infrared radiating element are used.
  • the heating element is a resistive heating element, or a resistive heating element and a heat conductor
  • the resistive heating element itself or the heat conductor that radiates the heat generated by the resistive heating element is placed in front of each cornea. , at a lateral position from below the front, or at a lateral position of each cornea, at a distance of 10 mm or more and 60 mm or less from the cornea, so that the heat radiated from the heating element is directional.
  • the heating unit is not heated by contacting the skin around the eyes, so there is no risk of burns.
  • the degree of corneal warming can be easily adjusted by controlling the set output, it is possible to safely, directly and effectively heat the cornea, relieve corneal pain as needed, and treat dry eye symptoms as desired. can be improved and treated.
  • it can be used as a new device for relieving corneal pain and improving and treating dry eye while performing daily life, work or leisure.
  • it can also be used as an eye treatment device in the medical field, it can be used as a new medical device that can treat eyes while doing daily life or work.
  • the pain in the cornea can be alleviated by warming the cornea, so the time during which the eyes are open without blinking (also referred to as "development time") can be increased, reducing eye fatigue. Also, eye and body discomfort can be reduced or eliminated. In addition, the eye can be relieved without feeling pain in the cornea, and a sense of relaxation and comfort can be realized.
  • dry eye by warming the cornea, it is possible to improve the factors of dry eye symptoms such as glare, eye irritation, eye pain, blurred vision, and difficulty seeing.
  • This corneal warming device is unprecedented as spectacles that can be used in daily life, as an attachment spectacle that can be attached to spectacles that are used daily, or as a functional goggle type or an eye cover type device.
  • the corneal warming device is a spectacles-type device that is equipped with spectacles in daily use, an attachment spectacles-type device that can be attached to spectacles in daily use, for function, and for AR. , goggle-type devices for VR and MR, eye cover-type devices, and ear hook-type devices.
  • the present invention by making the various types of devices described above, it can be used as a new device that can relieve corneal pain and improve/treat dry eye while performing daily life, work, or entertainment.
  • the glasses themselves for myopia and hyperopia can be used as corneal warming devices, so it is possible to prevent corneal pain while doing daily life and work. It can relieve eye irritation and improve and treat dry eye.
  • an attachment spectacle type device that can be attached to the spectacles used daily, it should be separate from the spectacles used daily, and the attachment spectacles should be used only when you want to warm the cornea to relieve pain or improve or treat dry eye.
  • the ear hook type device has a simple structure and is easy to put on and take off, and can alleviate corneal pain and improve/treat dry eye.
  • the resistance heating element is a metal, alloy or non-metallic material having resistance heating characteristics.
  • the resistive heating element is a metal, alloy or non-metallic material having resistive heating properties
  • the air heated by the resistive heating element is directly and effectively directed to the cornea from below, obliquely below or from the side. It can be transmitted to the target to warm the cornea, relieve pain in the cornea, and improve and treat dry eye.
  • the resistance heating element is connected to or covered with the heat transfer body made of metal or alloy with excellent thermal conductivity.
  • the resistance heating element is connected to or covered with the heat transfer body made of a metal or alloy having excellent thermal conductivity, the heat generated by the resistance heating element is transmitted over a wide area through the heat transfer body. .
  • the air warmed by the heat transfer body is directly and effectively transmitted from below or obliquely below to the cornea to warm the cornea, thereby relieving corneal pain and improving/treating dry eye.
  • the infrared radiation element is preferably an element that emits near-infrared rays or an element that emits far-infrared rays.
  • the thermal energy of electromagnetic waves in near infrared rays (wavelength about 780 nm to 3 ⁇ m) or far infrared rays (wavelength about 3 ⁇ m to 1 mm) warms the cornea by thermal radiation (radiation), thereby alleviating corneal pain. It can improve and treat dry eye.
  • the corneal warming device has a control device for controlling the heating element, and the control device is provided directly in the corneal warming device and controlled, or a wired communication device or It is controlled by a wireless communication device.
  • the corneal warming device preferably has a water retaining part that retains water or an aqueous solution.
  • the corneal warming device since humidity can be applied between the corneal warming device and the eye, it is possible to warm the cornea to provide moisture while alleviating corneal pain and improving/treating dry eye. can be done.
  • the water holding part is a cloth, a sponge, or the like containing water. Since such a corneal warming device can also moisturize the cornea, it can be used for improving or treating other eye symptoms and as a new medical device that can treat the eye while doing daily life, work or leisure.
  • the heating element maintains the function of warming the cornea and heats the heating element and its surroundings for safe use by the user. It has a protective structure that prevents direct contact with its parts.
  • the user since it has the above protective structure, the user does not accidentally touch the heating element directly, so that it can be used more safely.
  • a wave measuring device for measuring a potential obtained from the brain is connected to the control device, the potential measured by the electroencephalogram measuring device is frequency-converted, and the spectrum after the frequency conversion is obtained.
  • the controller is driven to warm the cornea by the heating element.
  • the brain recognizes pain when all or part of the range of 2 to 5 Hz in the frequency-converted spectrum exceeds a predetermined standard. If all or part of the 2-5 Hz range exceeds a predetermined criterion, the heating element can be activated to warm the cornea to the same or less than normal values. As a result, pain relief can be achieved.
  • a corneal pain evaluation apparatus includes an electroencephalogram measuring device for measuring potential obtained from the brain, frequency-converts the potential measured by the electroencephalography device, It is characterized in that the occurrence of corneal pain is evaluated when all or part of the values in the range of ⁇ 5 Hz exceed the criteria.
  • the cornea is warmed and pain is relieved by directly and effectively delivering heat to the cornea with direct heat radiation safely without obstructing vision (especially visual field). and improve and treat dry eye.
  • a corneal warming device capable of alleviating eye pain and alleviating or eliminating eye fatigue, etc., without disturbing vision (especially, visual field) while doing daily life, work, entertainment, etc., according to the present invention. can be done.
  • eye pain can be alleviated, eye fatigue, eye and body discomfort can be reduced or eliminated, and responsiveness can be achieved.
  • the eyes are relieved without feeling pain in the cornea, and the feeling of relaxation and comfort can be realized.
  • This corneal warming device can be used as a new device that can relieve corneal pain and improve and treat dry eye while doing daily life, work or entertainment. Furthermore, since it can also be used as an eye treatment device in the medical field, it can be used as a new medical device that can treat eyes while doing daily life or work.
  • FIG. 1 is a schematic configuration diagram showing an example of a spectacles-type corneal warming device according to the present invention, which is provided with a resistance heating element and a heat conductor;
  • FIG. 2 is an enlarged view showing a form in which a heat transfer body is provided on a lower rim in the spectacles-type corneal warming device shown in FIG. 1.
  • FIG. 3 is a photograph of the form shown in FIG. 2, which is a photograph of a prototype of a glasses-type corneal warming device.
  • FIG. 4 is a schematic configuration diagram showing another example of the spectacles-type corneal warming device according to the present invention, in which an infrared radiation element is provided on the lower rim.
  • FIG. 5 is an enlarged view showing a form in which an infrared radiating element is provided on the end piece in the spectacles-type corneal warming device shown in FIG. 4;
  • FIG. 6 is a photograph of the form shown in FIG. 5, which is a photograph of a prototype of a glasses-type corneal warming device.
  • FIG. 4 is a schematic diagram showing how the heat transfer body warms the cornea.
  • FIG. 4 is a schematic diagram showing how the infrared radiation element warms the cornea. It is a schematic diagram which shows the aspect which a cornea moistens. This is the result of measuring blinks before and after warming the cornea. It is a graph which shows the experimental result of development time. It is a graph which shows the time-dependent change of humidity.
  • FIG. 1 is a schematic diagram showing an example of an attachment glasses-type cornea warming device that can be detachably attached to glasses that are used daily.
  • FIG. 1 is a schematic configuration diagram showing an example of a goggle-type cornea warming device used for functions such as pollen and dust prevention, work, and sports, and for AR, VR, and MR of games.
  • 1 is a schematic configuration diagram showing an example of an ear-hung type corneal warming device;
  • FIG. Frequency characteristics of periodic synchronous discharge (PSD) (a) is normal PSD, (b) is PSD when pain is felt by forcibly opening the eyes, and (c) is corneal warming. This is the PSD when FIG.
  • PSD periodic synchronous discharge
  • FIG. 11 is an external view of a spectacles-type device used in Experiment 8; Dry Eye Questionnaire (OSDI). 1 is a graph showing dry eye results based on the Dry Eye Questionnaire (OSDI). Results of tear break-up time (BUT).
  • FIG. 11 is an external view of a spectacles-type device used in Experiment 9;
  • FIG. 24 is an explanatory diagram of an installation form of a resistance heating element of the spectacles-type device of FIG. 23; (A) is an illustration of a resistive heating element placed laterally on the cornea, and (B) is an enlarged view thereof.
  • a corneal warming device will be described with reference to the drawings.
  • the present invention is not limited to the following embodiments and examples as long as it includes the gist described in the present application, and can be modified in various ways.
  • the corneal warming device 1 has a heating element 12 that heats the cornea 20 to relieve pain and /or Device 1 for ameliorating dry eye, wherein the heating element 12 is a resistive heating element 12A.
  • the heating element 12 is a resistive heating element 12A.
  • each form of the corneal warming device 1 is a spectacles-type device 1A (Fig. 1 4, 19, and 23), an attachment spectacles-type device 1B (Fig. 15) that can be attached to the spectacles used daily, a goggle-type device 1C (Fig. 16) for function, AR, VR or MR, in front of the eyes
  • a cover type device not shown
  • an ear hook type device 1D FIG. 17
  • This corneal warming device 1 has a heating element 12 as an element for warming the cornea 20 to alleviate pain and/or improve dry eye.
  • a heating element 12 as an element for warming the cornea 20 to alleviate pain and/or improve dry eye.
  • the heating element 12 is the resistance heating element 12A or the resistance heating element 12A and the heat conductor 13
  • the resistance heating element 12A itself or the heat conductor 13 that radiates the heat generated by the resistance heating element 12A is the cornea 20.
  • the heating element 12 because it is located at a respective lower frontal position, a laterally from the frontal lower position, or a respective lateral position of the cornea 20 at a distance of 10 mm or more and 60 mm or less from the cornea 20;
  • the radiated heat is directed toward the cornea and can be delivered directly and effectively to the cornea 20 without being blocked by the eyelid, thereby relieving pain in the cornea 20 and improving dry eye. ⁇ Can be treated.
  • the infrared emitting element 12B that emits infrared rays
  • the present invention uses heat radiation with directivity to Since the cornea 20 can be directly and effectively warmed, pain in the cornea 20 can be alleviated and dry eye can be effectively improved and treated.
  • the heating unit is not heated by contacting the skin around the eyes, so there is no risk of burns.
  • the degree of warming the cornea 20 can be easily adjusted by controlling the set output, the cornea 20 can be warmed safely, directly, and effectively, and the pain of the cornea 20 can be alleviated or dry eye can be relieved as necessary.
  • Symptoms can be ameliorated and treated at will.
  • it can be used as a new device that can relieve pain in the cornea 20 and improve and treat dry eye while performing daily life, work or leisure.
  • it can also be used as an eye treatment device in the medical field, it can be used as a new medical device that can treat eyes while doing daily life or work.
  • the pain of the cornea 20 can be alleviated by warming the cornea 20 with the corneal warming device 1 according to the present invention. ) can be increased, and eye fatigue and eye and body discomfort can be reduced or eliminated. In addition, sensibly, the cornea 20 does not feel pain, the eyes are relaxed, and the feeling of relaxation and comfort can be realized.
  • dry eye by warming the cornea, it is possible to improve the factors of dry eye symptoms such as glare, eye irritation, eye pain, blurred vision, and difficulty seeing.
  • the corneal warming device 1 can be used as spectacles that can be used in daily life, as attachment spectacles that can be attached to spectacles that are used in daily life, as goggles for functions or games, as a cover in front of the eyes, or as an ear hook type. It is unprecedented and can be used without obstructing the field of view with the eyes open. Since it does not heat only the eyelid without warming the cornea 20, it can be worn by people who wear glasses on a daily basis and those who do not wear glasses while doing daily life, work, entertainment, etc., and directly and effectively warms the cornea 20. Thereby, the pain of the cornea 20 can be alleviated, and dry eye can be improved and treated.
  • position A below the front of the cornea refers to a position below the imaginary line Z1 extending horizontally in the front direction of the cornea 20 when the body and head are facing the front and the eyeballs are looking at the front.
  • Position B on the side from the lower front side of the cornea means that, at the above-described "lower front side” position A, on the imaginary line Z2 horizontally extending laterally from the position A in the left-right direction.
  • the "side position B of the cornea” is slightly different from the above-described "side position B from the lower front surface of the cornea", and extends horizontally in the lateral direction of the cornea 20 (in other words, "right lateral direction”). It means a position on a virtual line.
  • symbol B as the above is used for "the position B of the side of a cornea” for convenience. These will be described in detail in the section entitled “Placement of Heating Elements” below.
  • “upper”, “lower”, “upper”, and “lower” are based on the vertical direction Y, and “horizontal”, “right”, “left”, and “lateral” are The horizontal direction X is used as a reference.
  • a glasses-type corneal warming device 1A (hereinafter referred to as “glasses-shaped device 1A") is a pair of glasses that can be used in daily life and work, and the basic structure of such a glasses-shaped device 1A is shown in FIGS.
  • a transparent lens 2 a rim 3 (the part where the lens is fixed), an endpiece 4 (both ends of the glasses connecting the rim 3 to the temple 6), and a hinge 5.
  • the temple 6 (the part that supports the glasses.)
  • the modern 7 the part that touches the ear at the tip of the temple 6.
  • the nose pad 8 (the part that covers the nose).
  • the spectacles-type device 1A basically consists of a part that holds the glasses from both sides to support the eyeglasses), a bridge 9 (a part that connects the left and right lenses), and so on.
  • the form of the spectacles-type device 1A does not have to be limited to these, and depending on the fashion or unique spectacles form, any part of them may be omitted or the shape may vary in size. You can For example, the spectacles-type device 1A usually has a hinge 5, but when the overhanging portion 3a is large as shown in FIGS. In some cases, it does not have to be.
  • the spectacles-type device 1A is not such a special type of spectacles, but is an open-type spectacles-type device 1A or the like that is generally used and can be worn on a daily basis, as shown in FIGS. is preferred.
  • the spectacles type device 1A having such a general structure or a structure similar thereto, it can be used in various situations such as daily life and work, and can also be used as an eye treatment device in the medical field. can.
  • the present invention can be used as a new medical device that can treat the eyes while performing daily life or work, regardless of whether people wear glasses on a daily basis or not, and more people can enjoy the effects of the present invention (cornea 20 to relieve the pain of the cornea 20 to realize a feeling of relaxation and comfort, and/or to improve/treat dry eye).
  • the lens 2 may be either a glass lens or a plastic lens as long as it is transparent.
  • transparent is used to make it clear that vision is not obstructed like conventional medical and treatment glasses. Furthermore, it is for clarifying that it can be used in daily life.
  • it may be a lens that can cut a desired wavelength, a lens that has been corrected for myopia, hyperopia, or astigmatism, or a simple glass that is not corrected, or a lens such as sunglasses. It may be a tinted lens.
  • the materials of the rims 3, the endpieces 4, the hinges 5, the temples 6, the end pieces 7, the nose pads 8, etc., constituting the spectacle-shaped device 1A are also not particularly limited, whether they are made of resin, metal or otherwise. Further, the glasses may be made of different materials in each part. Those made of resin have good moldability and workability, and can be preferably used. Further, it may be transparent (including colorless transparent or colored transparent), colored opaque or translucent.
  • each of these parts has a different area area depending on the design of the spectacles, so when applying the components of the present invention to such spectacles, as described later, the rim 3 with a small installation area Instead, the heating elements 12 (resistance heating elements 12A and infrared radiation elements 12B) can be installed in areas where there is room for installation (such as the attachment 4 and the temples 6), and the entire spectacles can be slimmed down.
  • the heating elements 12 resistance heating elements 12A and infrared radiation elements 12B
  • the spectacles-type device 1A is configured by attaching a heating element 12 and the like to components of spectacles that are used daily and integrating them.
  • the components of the glasses that are used daily may be left as they are, and the heating element 12 and the like may be attached to the glasses as detachable parts (also referred to as attachment parts).
  • the heating element 12 and the like may be attached to the glasses as detachable parts (also referred to as attachment parts).
  • it may be an attachment spectacles type device 1B that can be attached to and detached from spectacles that are normally used, or the tip of an ear hook type corneal warming device 1D shown in FIG.
  • Only the heating element 12 or the like provided in the part may be detachably attached to the lower rim 3b or the lateral rim 3d of the spectacles normally used (not shown). By doing this, when it is desired to heat the cornea 20, it is possible to easily put on and take off the spectacles that are normally used, and the same effect as the spectacles type device 1A can be realized.
  • the attachment is used in the sense that it is detachably attached to the spectacles that are normally used.
  • the attachment spectacles-type device 1B is used by attaching to and detaching from normal spectacles. It is constructed in a large form so as not to cover the glasses in use and get in the way.
  • Reference numeral 31 represents a part to be attached to spectacles used in normal times, and the specific attachment form is not particularly limited, and various means can be applied like commercially available attachment spectacles for other functional purposes.
  • the attachment spectacles type device 1B has a large shape so that the radiation from the resistance heating element 12A and the infrared radiation element 12B, which will be described later, is not blocked by the presence of the spectacles during normal operation. It is preferable to increase the width of the upper rim 3c, the end piece 4, and the like, and put them on the spectacles during normal use.
  • Control device 11 controls the heating element 12 .
  • the heating element 12 is operated under the control of the control device 11, and as a result, the temperature of the cornea 20 can be adjusted to a safe and appropriate temperature and easily warmed.
  • Such control reduces or eliminates eye fatigue and discomfort in the eyes and body without causing the cornea 20 to feel pain, and provides a sense of relaxation and comfort.
  • by warming the cornea it is possible to improve the factors of dry eye symptoms such as glare, eye irritation, eye pain, blurred vision, and difficulty in seeing.
  • the control device 11 is a control circuit that includes an electric circuit and controls the heating element 12 based on the power supplied from the power supply.
  • the current can be optionally controlled by the resistivity of the heating element 12 if it is a resistive heating element 12A, or by its resistivity if the heating element 12 is an infrared emitting element 12B. It can be arbitrarily controlled according to the voltage-current characteristics of the infrared radiation element 12B.
  • a small storage battery may be provided in the spectacles (for example, the temple 6 or the like), or power may be supplied by connecting the spectacles with an electric wire.
  • the control device 11 may be provided at any position on the glasses-type device 1A.
  • the control device 11 may preferably be provided at a site other than the rim 3 (for example, the temple 6, etc.), or may be wired. It may be connected and attached to a pocket or part of the body or clothing.
  • the control device 11 may be provided in addition to the spectacles.
  • control application software also referred to as the control device 11 in the present application
  • a mobile terminal such as a smartphone
  • the control device 11 controls the resistance heating element 12A and the infrared radiation element 12B, the temperature to which the cornea 20 is heated when the voltage is applied is evaluated in advance, and the cornea 20 is heated on the premise of safety.
  • the applied voltage may be set based on the result of how much it can be heated, the applied voltage may be set based on the signal from the temperature sensor 14, or set by other temperature control methods.
  • the output is strengthened for 5 minutes during work, and then continued to use stepwise control that is weakened, or the timer is set to output for 10 minutes and then It is preferable that the control device 11 can be used for ON/OFF control or the like for turning OFF.
  • the spectacles-type device 1A When the spectacles-type device 1A is provided with a water holding portion 16, which will be described later, and includes a configuration for imparting humidity between the spectacles-type device 1A and the cornea 20, the above-described control device 11 removes moisture in the water holding portion 16.
  • a function of driving an element for volatilization resistive heating element 17, ultrasonic transducer, etc. may be provided. These elements may be driven by the controller 11 described above, or may be driven by another controller (not shown).
  • the resistance heating element 12A can be a general resistance heating element and is controlled by the controller 11 to generate heat.
  • the resistance heating element 12A applies a control current to the resistance heating element 12A, heats the air near the resistance heating element using the Joule heat, and heats the cornea 20 by thermal conduction of the warmed air.
  • the degree of heating (degree of temperature) can be easily controlled by voltage control.
  • the material of the resistive heating element 12A is preferably a metal, alloy or non-metallic material having resistive heating properties.
  • Such resistive heating elements 12A are preferably made of iron, chromium, aluminum, nickel, chromium, molybdenum, tungsten, alloys thereof, silicon carbide, carbon, or the like. These various materials have respective resistivities (for example, resistivity of copper at 20° C.: 2.28 ⁇ 10 ⁇ 8 ⁇ ).
  • the form of the resistance heating element 12A is not particularly limited, it may be a linear resistance heating wire, a foil-type resistance heating foil or pattern, or a sheet-like resistance heating sheet or sheet pattern in terms of workability and ease of attachment. is preferred. It is preferable that the wire diameter, size, thickness, etc. are arbitrarily designed according to the amount of heat generated and the configuration of the installation position, and that an appropriate configuration is selected and provided.
  • the resistance heating element 12A is attached to the glasses-type device 1A as it is, and when the surrounding air is warmed by the heating of the resistance heating element 12A itself, the air can effectively warm the cornea 20. Also, as shown in FIGS. 1, 2 and 7, it is preferable that the resistance heating element 12A is connected to the heat conductor 13, or the resistance heating element 12A is covered with the heat conductor 13. FIG. By doing so, heat is transferred via the heat transfer body 13 to warm the surrounding air, and the air can effectively warm the cornea 20 . Of these, it is preferred that the resistive heating element 12A heats the surroundings via the heat conductor 13. As shown in FIGS. is preferably provided from the viewpoint of realizing effective heating.
  • the heat transfer body 13 may be provided only on the lower rim 3b, but may be provided on other parts (upper rim 3c, lateral rim 3d, etc.) together with the lower rim 3b. .
  • FIG. 7 is a schematic diagram showing how the heat transfer body 13 provided on the lower rim 3b warms the cornea 20.
  • FIG. The heat generated by the resistance heating element 12A is transmitted to the heat transfer body 13 provided on the lower rim 3b, and the heat transfer body 13 is heated.
  • the air warmed by the heated heat conductor 13 is transmitted in the direction D1 of the cornea 20 as shown in FIGS. 7A and 7B, and can effectively warm the cornea 20.
  • the heat transfer body 13 should be positioned as close to the cornea 20 (the diameter of the cornea is about 11 mm) as possible at the lower rim 3b.
  • the distance L from the heat transfer body 13 to the cornea 20 is about 10 to 60 mm, preferably about 20 to 25 mm, compared to the case where the heat transfer member 13 is provided at other parts of the rim 3 (upper rim 3c, lateral rim 3d). , the distance to the cornea 20 is the closest.
  • the output of the heating control is increased. It can be used most efficiently, and power saving, safety, and controllability can be improved at the same time.
  • FIG. 7 the virtual line C when viewed from the front is shown, but especially when working at a desk with a personal computer, face down so that the virtual line C is tilted downward, and the viewing range ⁇ of the screen and the keyboard Work while looking at the included visual field range ⁇ (see FIGS. 13 and 14).
  • the eyelids tend to close more than when looking straight on. Therefore, compared to the case where the heat transfer body 13 is provided on the upper rim 3c or the lateral rim 3d, the case where the heat transfer body 13 is provided on the lower rim 3b is more suitable for the cornea from below where the lower rim 3b is located. 20 can be directly and effectively heated.
  • 7 indicates the direction from the heat transfer body 13 to the cornea
  • reference character C indicates an imaginary line connecting the spectacle lens 2 and the cornea 20 when viewed from the front.
  • a material having good thermal conductivity can be preferably used.
  • a foil or sheet made of copper or a copper alloy, a foil or sheet made of aluminum or an aluminum alloy, or other metals or alloys having good thermal conductivity can be used. It is preferably a foil or sheet consisting of
  • the resistance heating element 12A is, for example, a linear resistance heating element 12A
  • a copper foil provided with an adhesive layer is attached as the heat conductor 13 to the lower rim 3b with the linear resistance heating element 12A interposed therebetween.
  • the linear resistance heating element 12A may be integrally molded with the resin lower rim 3b, or a foil-shaped or sheet-shaped heat transfer element 13 may be mounted on the integrally molded element. It can be pasted together.
  • the thickness and size (vertical and horizontal) of the foil or sheet are not particularly limited, and may be any dimension that allows the shape to be bent and attached to the lower rim 3b.
  • the thickness of the heat conductor 13 may be from several microns to several hundreds of microns.
  • the width of the heat transfer body 13 may be approximately the same as the length of the lower rim 3b, ie, 3 to 5 cm. The depth width may be sufficient, and may be about 50% to 80% of the depth width of the lower rim 3b.
  • the lower rim 3b does not have a heat transfer body, and the resistance heating element 12A, which is installed at a lateral position just beside the cornea, heats the cornea from a nearby area, and also heats the cornea by mistake. It is characterized by providing a protector structure that prevents the resistance heating element 12A from being touched. This is different from the mode in which the heating is performed by the heat transfer body 13 that transfers heat from the resistance heating element.
  • Such a protector structure maintains the function of the heating element 12 (for example, the resistance heating element 12A) to heat the cornea 20, and also protects the heating element 12 and the heating area around the heating element 12 for safe use by the user. It can be said that it is a protective structure that cannot be directly touched.
  • the corneal warming device according to the present invention desirably has such a protective structure, and such a protective structure is, for example, a structure that protects areas other than an opening that is large enough to prevent a fingertip from directly touching the heating element 12. is preferred.
  • the "lateral position just beside the cornea” is slightly different from the above-described "position B that is lateral from the lower front surface of the cornea", and is in the lateral direction of the cornea 20 (in other words, the "right lateral direction”). It means a position on a horizontally extending imaginary line, and specifically, in a spectacles type device, as shown in FIGS. It means distance.
  • the infrared radiation element 12B is controlled by the control device 11 and emits infrared rays in the direction D2 of the cornea 20, which is an object to be irradiated, and warms the cornea 20 by the radiation. be.
  • the infrared radiation element 12B is provided at a position where the radiated infrared rays easily hit the cornea 20 and in a direction D2 (see FIG. 8) where the emitted infrared rays hit the cornea 20 with directivity. It is desirable that Specifically, it is preferable to be provided on the lower rim 3b (see FIG. 4). 6) or on the lateral rim 3d.
  • a near infrared radiation element (LED with a wavelength of about 780 nm to 3 ⁇ m) or a far infrared radiation element (LED with a wavelength of about 3 ⁇ m to 1 mm) can be used. Both devices can easily control the output by voltage.
  • a small, low-power near-infrared emitting element that emits near-infrared rays an LED can be mentioned.
  • a small, low-power far-infrared radiation element that emits far-infrared radiation can be employed.
  • Small, low-power far-infrared radiating elements that radiate far-infrared rays are not yet on the market at present, but it is desirable to adopt devices that achieve miniaturization and low power.
  • the thermal energy of the electromagnetic waves radiated from these elements can warm the cornea 20 by thermal radiation (radiation).
  • the infrared radiation element 12B is preferably provided on the lower rim 3b, the lateral rim 3d, or the end piece 4 among the rims 3.
  • the face is turned downward to look at the screen and the keyboard below, so the eyelids tend to close more than when viewed from the front. Therefore, compared to the case where the infrared radiation element 12B is provided on the upper rim 3c, by providing the infrared radiation element 12B on the lower rim 3b, the infrared radiation can be directed toward the direction D2 of the cornea 20 from below where the lower rim 3b is located. It can radiate infrared rays directly and effectively.
  • infrared radiating element 12B can be installed on the joint 4 (see FIGS. 5 and 6) or on the lateral rim 3d, where the installation space can be secured. Infrared rays can be directly and effectively radiated toward the direction D2 of the cornea 20 from the front. 7 indicates the direction of the cornea 20 from the infrared radiation element 12B.
  • the distance L from the lower rim 3b to the cornea 20 is about 10 to 60 mm, preferably about 20 to 25 mm.
  • the distance to the cornea 20 can be shortened compared to when it is provided on the rim 3c.
  • the output and the number of installed infrared radiation elements 12B are not particularly limited, it is preferable to provide the output and the number that can warm the cornea 20 .
  • three infrared radiation elements 12B are provided on the end piece 4, but the number may be three as in the experiments described later, or four, five, or more. It is desirable that the radiated infrared rays are provided in such a direction that the cornea 20 is easily hit by the cornea 20 with directivity and position.
  • the infrared radiation element 12B does not heat the air by thermal conduction, so the heat conductor 13 is unnecessary.
  • the temperature of the cornea 20 can be measured with a temperature sensor 14 .
  • a contact-type temperature sensor 14 (combined with reference numeral 14) that indirectly measures the temperature of the air between the glasses-type device 1A and the cornea 20, or a non-contact temperature sensor that directly measures the temperature of the cornea 20 is used.
  • a non-contact temperature sensor 14B can be mentioned.
  • a thermocouple, a resistance temperature detector, or a thermistor can be used as the contact temperature sensor 14 .
  • the contact-type temperature sensor 14 cannot directly contact the cornea 20 for measurement, but can measure the temperature of the air between the spectacles-type device 1A and the cornea 20 .
  • a radiation thermometer can be given as the non-contact temperature sensor 14B. The radiation thermometer is based on the principle of sensing infrared rays emitted by an object and measuring the temperature from the amount of radiation, so the surface temperature of the cornea 20 can be measured.
  • the resistance heating element 12A warms the air, and the air warms the cornea 20, so the contact temperature sensor 14 should be provided at a position where the temperature between the glasses-type device 1A and the cornea 20 can be measured. How warm the cornea 20 is can be roughly estimated by measuring the temperature of the air in the vicinity of the cornea with the contact temperature sensor 14 .
  • a contact temperature sensor 14 is provided at an appropriate location on the rim 3, temple 6, bridge 9 or end piece 4. Alternatively, the surface of the cornea 20 may be directly measured by the non-contact temperature sensor 14B.
  • the non-contact temperature sensor 14B When the non-contact temperature sensor 14B is employed, it can be installed at a position (specifically, the upper rim 3c or the lower rim 3b) where the cornea 20 is easily irradiated with infrared rays emitted from the non-contact temperature sensor 14B. desirable.
  • the infrared radiation element 12B heats the cornea 20 by thermal radiation (radiation)
  • the thermal energy of the electromagnetic waves emitted by the infrared radiation element 12B makes it difficult to determine how warm the cornea 20 is by measuring the temperature of the air. Therefore, it is desirable to measure the surface temperature of the cornea 20 with a radiation thermometer, which is the non-contact temperature sensor 14B. Even if the non-contact temperature sensor 14B is not provided, the non-contact temperature sensor 14B can be omitted by confirming in advance the relationship between the voltage applied to the infrared radiation element 12B and the temperature at that time. can.
  • a humidity sensor is preferably provided as necessary in order to measure the humidity between the glasses-type device 1A and the cornea 20.
  • a humidity sensor integrated with temperature measurement may be used, or a humidity sensor may be provided independently.
  • the moist state of the cornea 20 can be evaluated. In particular, when both heating and humidification are performed, both warmth and moisture are compatible, and the cornea 20 is warmed and moistened, so that the cornea 20 is in a state similar to a so-called sauna (also called "eye sauna").
  • eye fatigue and discomfort in the eyes and body can be further reduced or eliminated, and the eyes are responsively relieved, the cornea 20 does not feel pain, and a feeling of relaxation is achieved. You can feel the comfort even more.
  • dry eye can be improved and treated while being adjusted to a moist state.
  • the water holding part 16 is provided as necessary and holds water or an aqueous solution. By arranging the water holding part 16 in the form illustrated in FIGS. 1 to 6, the moisture held by the water holding part 16 is evaporated, thereby providing an appropriate amount of humidity between the spectacles-type device 1A and the cornea 20. As a result, the cornea 20 can be warmed and moisturized.
  • the water holding part 16 is preferably in the form of a container including cloth, sponge, etc. containing water.
  • the structural form of the water retaining portion 16 is not particularly limited.
  • the temple 6 is attached with a plastic container.
  • the container may contain the water or the aqueous solution as it is, or may contain a liquid-absorbing or liquid-retaining material such as a sponge or felt impregnated with the water or the aqueous solution.
  • the water holding portion 16 may be integrated with the spectacles-type device 1A, or may be a cartridge container detachable from the spectacles-type device 1A. If necessary, it may be configured to have a replenishing port for replenishing water or aqueous solution, or may be configured to have an opening through which water or aqueous solution can be replaced.
  • the water holding part 16 is preferably provided on the temple 6, which is easier to wear than other parts of the spectacles, but may be provided on a part of the spectacles other than the temple 6. Alternatively, it may be a separate container and connected to the spectacles type device 1A with a tube or the like.
  • the water or aqueous solution in the water holding part 16 is heated and has the effect of increasing the humidity around the eyes.
  • the water holding part 16 mainly holds water, but may be an aqueous solution containing other components.
  • An aqueous solution is water or the like containing a water-soluble substance, and examples of water-soluble substances include inorganic substances and organic substances that dissolve or disperse in water.
  • the water is not particularly limited as long as it is clean water, and may be tap water, commercially available mineral water, distilled water, or ion-exchanged water.
  • the water or aqueous solution held by the water holding part 16 may contain various medicinal additives depending on the purpose.
  • Evaporation of moisture in the water holding portion 16 may be performed by a heating element (for example, the resistance heating element 17) provided integrally with the water holding portion 16, or may be performed by a heating element connected to the resistance heating element 12A.
  • the heat body 13 may be extended to the water holding part 16, and the heat of the heat transfer body 13 may evaporate the moisture.
  • a resistance heating element 17 (different from the above resistance heating element 12A) is provided integrally with the water holding portion 16, and the resistance heating element 17 is heated. It is preferable to evaporate the moisture.
  • an ultrasonic vibrator may be used as an element other than the heating element. The ultrasonic vibrator can vibrate water and emit it as fine water particles.
  • FIG. 7 is a schematic diagram showing how the heat conductor 13 warms the cornea 20.
  • FIG. 7(A) shows the initial stage in which the air is heated by the heat transfer element 13 provided on the lower rim 3b of the spectacles.
  • FIG. 7B shows a mode in which the air is further heated by the heat transfer body 13 and reaches the cornea 20 .
  • the spectacle-type device 1A according to the present invention preferably has a shape in which the rim 3 is made large so that the heating region 15 heated between the lens 2 and the cornea 20 does not easily escape outward.
  • FIG. 8 is a schematic diagram showing how the infrared radiation element 12B warms the cornea 20.
  • FIG. The example of FIG. 8 is a case where the infrared radiation element 12B is provided on the lower rim 3b shown in FIG. In this mode, the infrared rays are directed toward the direction D2 of the cornea 20 .
  • the cornea 20 is warmed by radiant heat generated when the infrared rays 19 emitted from the infrared radiation element 12B reach the cornea 20 .
  • Reference numeral 14C denotes infrared rays for measurement emitted from the radiation thermometer, which is the non-contact temperature sensor 14B.
  • Both the infrared radiation element 12B and the non-contact temperature sensor 14B radiate infrared rays (19, 14C). preferably installed.
  • the cornea 20 can be effectively warmed, and the temperature of the cornea 20 can be measured more accurately.
  • FIG. 9 is a schematic diagram showing how the cornea 20 is moisturized.
  • the temple 6 of the glasses is provided with a water holding portion 16, and the water in the water holding portion 16 is volatilized by a heating element such as a resistance heating element 17. It shows an early stage embodiment.
  • the humidification area 18 is formed by volatilizing water from the water holding portion 16 .
  • FIG. 9(B) shows a state in which the water is further volatilized from the water holding portion 16 and reaches the cornea 20 to moisten the cornea 20 .
  • the spectacles-type device 1A according to the present invention preferably has a larger rim 3 so that the humidified area 18 between the lens 2 and the cornea 20 is less likely to escape outward.
  • chronic eye pain In the field of ophthalmology, the number of patients complaining of chronic pain (referred to as chronic eye pain) is increasing. Such chronic eye pain can be relieved by the warm analgesic method. It has been found that it can be relieved by using the eyelids. It has also been found that chronic ocular pain improves when eyelids are closed, when saunas or bathing are performed. However, the current onan method only covers the eyes, and the patient has to remain still with his eyes closed during that time, so it is not possible to obtain such effects during daily life and work. Further, the technique proposed in Patent Document 5 warms only the eyelid portion without affecting the cornea or the eyeball.
  • the spectacles-type corneal warming device 1A can deliver heat directly and effectively to the cornea 20 without being blocked by the eyelids, thereby relieving pain in the cornea 20 . Therefore, it is possible to increase the time for which the eyes are opened without blinking, thereby reducing or eliminating eye fatigue and discomfort of the eyes and the body. In addition, sensibly, the cornea 20 does not feel pain, the eyes are relaxed, and the feeling of relaxation and comfort can be realized.
  • This corneal warming device 1 can be used in daily life, during work, during games, etc.
  • the spectacles-type corneal warming device 1A and the attachment spectacles-type corneal warming device 1B have been described above.
  • the type device 1C), the ear hook type corneal warming device 1D, and the anterior covering type corneal warming device 1 (not shown) will be described. Note that the anterior cover type corneal warming device 1 is not described, but is the same as other corneal warming devices 1 .
  • FIG. 16 shows a representative form of the goggle-type device 1C.
  • the goggle-type device 1C can be applied to prevent pollen and dust, for work, for functions used in sports such as skiing, and for AR, VR, or MR of games. Unlike the see-through type AR and MR, the goggles for VR are closed without visibility, but the goggles for VR are used with the eyes open. be.
  • Such a goggle-type device 1C similarly has the components of the spectacle-type device 1A. In particular, the direction and position of the heating element 12 (resistance heating element 12A, infrared radiation element 12B) are the same.
  • FIG. 17 shows a typical form of the ear hook type device 1C.
  • the ear hook type device 1D can be used as a simpler corneal warming device 1A.
  • Numeral 41 is an ear-hung arm, the heating element 12 is attached to the tip side thereof, and the rear end side is devised so as to be stably hung on the ear.
  • This ear-hook type device 1D also has the components of the spectacles type device 1A. In particular, the direction and position of the heating element 12 (resistance heating element 12A, infrared radiation element 12B) are the same.
  • the heating element 12 is placed at a position A below the front surface of the cornea, at a position B lateral from the lower front surface of the cornea, or on each side of the cornea. It is desirable that the distance from the cornea 20 be 10 mm or more and 60 mm or less at both positions A and B.
  • Position A below the front of the cornea refers to a position below an imaginary line Z1 extending horizontally in the front direction of the cornea 20 when the body and head are facing the front and the eyeballs are looking at the front. Preferably, it is positioned at a distance of 10 mm or more and 60 mm or less from the cornea 20 in a direction forming an angle ⁇ 1 of 5° or more and 45° or less downward from the horizontally extending imaginary line Z1.
  • the "position B on the side from the front lower side of the cornea” means the position on the imaginary line Z2 extending horizontally laterally from the position A in the above-described "front lower side” position A.
  • the "position on each side of the cornea” means the position on the side right next to the cornea. It means a position on an imaginary line extending horizontally in the left-right direction (in other words, "right lateral direction”).
  • the spectacles-type device uses the eyepiece or the lateral rim on the side of the eyepiece at a distance of 10 mm or more and 60 mm or less away from the cornea 20. is at a distance close to .
  • the heating element 12 By providing the heating element 12 at a position A below the front of the cornea 20 , at a position B lateral from the front below the cornea, or at a position lateral to each of the cornea, the heating element 12 is directionally applied to the cornea 20 . can be directed well. Further, by positioning the heating element 12 at a distance of 10 mm or more and 60 mm or less away from the cornea 20, the heat radiated from the heating element 12 is radiated in the direction of the cornea with directivity, Heat can be delivered directly and effectively to the cornea without being blocked by the eyelid, thereby relieving pain in the cornea and improving/treating dry eye.
  • the infrared emitting element 12B that emits infrared rays
  • the corneal warming device 1 of the present invention can be various types of devices and can be used while performing daily life, work or leisure. It can be used as a new device capable of relieving pain in the cornea 20 and improving/treating dry eye.
  • the spectacles-type device 1A provided in the spectacles used daily, the spectacles themselves for myopia, hyperopia, etc. can be used as the cornea warming device. It can relieve the pain of the eye and improve and treat dry eye.
  • the attachment spectacles type device 1B that can be attached to the spectacles that are used daily, it is separate from the spectacles that are used daily, and it is desired to warm the cornea 20 to relieve pain or improve/treat dry eye. It can be worn as attachment glasses only on the eye to relieve corneal pain and improve and treat dry eye.
  • the functional, AR, VR, or MR goggle-type device 1C and eye cover-type device can be used, for example, for preventing pollen and dust, for work, for sports, for games, for IT business, and the like.
  • the pain of the cornea 20 can be alleviated and dry eye can be improved and treated while using it.
  • the ear hook type device 1D and the eye cover type device have a simple structure and are easy to put on and take off, and can alleviate the pain of the cornea 20 and improve/treat dry eye.
  • an electroencephalogram measuring device for measuring a potential (microvolt potential) obtained from the brain is connected to the control device 11, and the potential measured by the electroencephalograph is frequency-converted.
  • the cornea 20 can be warmed by the heating element 12 by driving the controller 11 when all or part of the values in the range of 2 to 5 Hz in the converted spectrum exceed the reference.
  • the brain recognizes pain, as demonstrated by the results of Experiment 7 below.
  • the heating element 12 can warm the cornea 20 to the same or less than normal values. As a result, pain relief can be achieved.
  • this application proposes an objective evaluation device and an objective evaluation method for corneal pain. That is, the corneal pain evaluation device and evaluation method are provided with an electroencephalogram measuring device for measuring microvolt potentials obtained from the brain, frequency-converting the potentials measured by the electroencephalography measuring device, An apparatus and method for objectively evaluating the occurrence of corneal pain when all or part of the values in the range of ⁇ 5 Hz exceed the standard.
  • the spectacles type device 1A has a control device 11 attached to the left and right temples 6, a resistance heating element 12A attached to the left and right end pieces 4, and a copper foil ( 0.1 mm thick, 60 mm long, 8 mm wide (long side), 2 mm wide (short side)) and placed in contact with the resistive heating element 12A for heat conduction.
  • a copper foil 0.1 mm thick, 60 mm long, 8 mm wide (long side), 2 mm wide (short side)
  • the resistance heating element 12A used has a resistance of 25 ⁇ , and is configured so that the output (temperature adjustment) can be adjusted in three steps (modes 1, 2, and 3 in descending order of output).
  • a water retaining portion 16 having a capacity of about 0.3 mL was further provided on each of the temples 6 on both sides of the glasses-type device 1A. did not enter An experiment was conducted with the spectacles type device 1A configured in this way.
  • the resistance heating element 12A conducts heat to the heat transfer body 13 by heating itself, warms the air around the heat transfer body 13, and the air effectively warms the cornea 20.
  • the temperature of the cornea 20 is measured using a temperature/humidity sensor (manufactured by Sensirion Co., Ltd., trade name: thermohygrometer evaluation kit EK-H4) capable of measuring temperature and humidity. Temperatures between 20 and 20 were measured. The room temperature at the time of measurement was 25.0°C.
  • the results are shown in Table 1. From the results in Table 1, the temperature of the right cornea was increased by 1.6° C. at maximum compared to the left cornea when heated in Mode 1. When heated in mode 3, the right cornea had a maximum temperature rise of 2.0°C compared to the left cornea.
  • the tester's sensitivity evaluation was also performed. There are 5 levels of response evaluation: 5 (very warm or very pleasant), 4 (warm or pleasant), 3 (slightly warm or slightly pleasant), 2 (slightly warm or slightly pleasant), 1 (warmth or pleasantness). I don't feel it).
  • the results were a sensory evaluation of 2 for the right eye when heated in Mode 1, and a sensory evaluation of 1 for the left eye not heated by the resistance heating element 12A.
  • the right eye when heated in mode 3 had a sensory rating of 4, and the left eye without heating had a sensory rating of 1.
  • Example 2 Using the same spectacles as in Experiment 1, both the right and left resistive heating elements 12A were heated in Mode 3 to warm both the left and right eyes of the subject for 10 minutes. Although the temperature at this time was not measured, it seemed that at least the same level of temperature rise as in Experiment 1 had been achieved, and the sensory evaluation was similar to Mode 3 of Experiment 1. Measurements were taken by wearing spectacles, and the number of blinks before warming and the number of blinks after warming. FIG. 10 and FIG. 11 compare the elapsed blink time (seconds) and the blink interval (seconds) before and after heating (before and after) in a relaxed natural state, measured for 1 minute. In addition, at the time of measurement of blinking, the wearer changed to ordinary glasses.
  • the average blink interval was 3.8 seconds, but after warming, the interval was 5.5 seconds. Furthermore, the interval between blinks (referred to as "maximum development time") during which the subjects consciously endured blinking was measured. As a result, before warming, the average maximum development time was 19 seconds, and after warming, the average maximum development time was 33 seconds. The frequency of such blinking increases when the cornea 20 feels pain, discomfort, or discomfort. In this experiment, pain was caused in the cornea 20 by consciously resisting blinking, but the pain in the cornea 20 was alleviated by warming the cornea. As a result, it can be said that the maximum eye-opening time is lengthened, the cornea 20 does not feel pain, and a feeling of relaxation and comfort can be realized.
  • Experiment 3 Using the same spectacles as in Experiment 1, changes over time in humidity measurement were measured. Since the spectacles of Experiment 1 are provided with water holding portions 16 on the temples 6 on both sides, a sponge impregnated with 0.3 mL of water was put into the water holding portions 16 .
  • the water holding portion 16 is provided with a resistance heating element 17 different from the resistance heating elements 12A on both the left and right sides, so that it can be controlled independently of the resistance heating elements 12A.
  • the resistance heating element 17 has a resistance of 75 ⁇ and is arranged in the water holding portion 16 .
  • the resistance heating element 12A for warming the cornea was operated in the same Mode 3 as in Experiment 1, and the resistance heating element 17 in the water retaining portion 16 was heated to volatilize the moisture in the water retaining portion 16.
  • the temperature and humidity before and after that were measured with a temperature/humidity sensor.
  • the gap between the spectacles-type device 1A and the cornea 20 was closed with a tape to minimize the influence of humidity in the outside air.
  • FIG. 12 is a graph of humidity changes over time. As shown in FIG. 12, the humidity fluctuated with a slight movement of the face (head), but the average value from when the temperature stabilized (at 17:30) to when it was removed (at 17:55) was , the relative humidity was 55.4% and the temperature was 34.7°C. The relative humidity had increased by about 10% and the temperature had increased by 3°C.
  • a glasses-type device 1A shown in FIG. 6 was produced.
  • the spectacles-type device 1A has a control device 11 mounted on both left and right temples 6, and three infrared radiation elements 12B mounted on each of the left and right end pieces 4 respectively.
  • the three infrared rays rays 12B provided on each of the left and right armor pieces 4 are positioned.
  • only the infrared radiation element 12B on the right side was controlled in order to compare the temperature rise effects on the left and right sides.
  • An 890 nm near-infrared LED (manufactured by epitex, trade name: L890-40M) was used as the infrared radiation element 12B. 5.11 V, 0.19 A (0.97 W) was input to the near-infrared LED.
  • the vibrational energy of the near-infrared radiation causes the molecules of the cornea 20 to vibrate and generate heat, generating a radiation phenomenon.
  • the temperature of the cornea 20 is measured using a radiation thermometer (manufactured by AIDBUCKS, trade name: PM6530B), which is the non-contact temperature sensor 14B. was measured. In this measurement, a hole was made in a part of the lens, the hole was closed with a film, and the non-contact temperature sensor 14B was used to measure the temperature through the hole through which the film was removed. The room temperature at the time of measurement was 26.7°C. The results are shown in Table 2.
  • the temperature of the right cornea irradiated with near-infrared rays of 890 nm increased by a maximum of 1.0° C. compared to the left cornea.
  • Sensitivity evaluation was also performed when the cornea was warmed. The sensory evaluation was similar to that described in Experiment 1, and the results were a sensory evaluation of 4 for the right eye exposed to near-infrared radiation and a sensory evaluation of 1 for the left eye not exposed to near-infrared radiation. From these results, it was found that by increasing the temperature of the cornea by a maximum of 1.0° C., the cornea 20 does not feel pain and warmth or comfort can be obtained.
  • a glasses-type device 1A was produced in the same manner as in Experiment 4.
  • the control device 11 is attached to the left and right temples 6, and three infrared radiation elements 12B are attached to the right and left end pieces 4, respectively.
  • the three infrared radiation elements 12B on each of the right and left end pieces 4 were positioned so that the direction of radiation of the infrared rays would be directed toward the eyes as much as possible.
  • only the infrared radiation element 12B on the right side was controlled in order to compare the temperature rise effects on the left and right sides.
  • An 850 nm near-infrared LED (manufactured by epitex, trade name: L850-40M00) was used as the infrared radiation element 12B. 5.12 V, 0.14 A (0.72 W) was input to the near-infrared LED.
  • a glasses-type device 1A was produced in the same manner as in Experiment 4.
  • a control device 11 is attached to the left and right temples 6, and three infrared radiation elements 12B are attached to the left and right end pieces 4, respectively.
  • the three infrared radiation elements 12B on each of the right and left end pieces 4 were positioned so that the direction of radiation of the infrared rays would be directed toward the eyes as much as possible.
  • only the infrared radiation element 12B on the right side was controlled in order to compare the temperature rise effects on the left and right sides.
  • a near-infrared LED of 1450 nm (manufactured by Ushio Inc., trade name: SMBB1450-1100-02) was used as the infrared radiation element 12B. 5.0 V and 138 mA were input to the near-infrared LED.
  • the outputs of the resistance heating element 12A and the infrared radiation element 12B and the heating output of the water holding portion 16 are set respectively.
  • the experimental results of Experiments 1 to 6 are the results at the set values, and it is possible to arbitrarily control the temperature and humidity. Specifically, it is possible to raise or lower the temperature and humidity by direct output adjustment. Also, by changing the structure of the spectacles, the space between the spectacles and the eyes is kept out of contact with the outside air as much as possible, so that the degree of heating and the degree of humidification can be arbitrarily adjusted.
  • the present invention was made from the viewpoint that the cause of discomfort such as increased blinking may be related to the influence of pain receptors present in the cornea.
  • the present invention has been made based on the finding that the stimulus to the body can be alleviated and a feeling of relaxation and comfort can be realized.
  • eye pain in the state of forcibly opening the eyes was examined. The experiment was conducted in a cycle in which the subjects were asked to spontaneously and freely blink for 30 seconds, then forced to open their eyes for 30 seconds, and then again spontaneously and freely blink for 30 seconds.
  • electroencephalogram measurement was performed based on the literature (Scientific Report, Vol. 11, No. 3192, pp. 1-10) when eye pain occurred during forced eye opening, and the vertical axis was PSD (power spectrum density), and the horizontal axis is a value obtained by converting the frequency of the electroencephalogram (frequency: Hz; the same shall apply hereinafter).
  • PSD power spectrum density
  • the vertical axis indicates the relative value of PSD (scale: 0 to 1), and the horizontal axis indicates the value (Hz) when the electroencephalogram is frequency-converted.
  • the electroencephalogram in FIG. 18, which will be described later, is the result of measurement immediately after forced eye opening for 30 seconds.
  • the results are shown in FIG.
  • the three bars at each frequency are the results when the bar on the left side of symbol a is normal without heating, the bar on the center side of symbol b is the result when pain is felt, and the symbol c.
  • the bar on the right is the result when the cornea was warmed by heating.
  • symbol b when pain is felt, the frequency of electroencephalograms in the range of 2 to 5 Hz is higher than that in normal times (reference), and pain is generated by comparing the range of 2 to 5 Hz.
  • FIG. 19 is an external view of the glasses-type device used in Experiment 8.
  • This spectacles-type device has the same structural form as that of Experiment 1, but is an actual spectacles-type device in which the lenses do not have holes for measurement.
  • this spectacles-type device employs two resistance heating elements 12A with a resistance of 50 ⁇ as heating elements arranged on the left and right sides respectively. The one that allowed 124 mA to flow when applied was used.
  • These heating elements are configured so that the output (temperature control) can be adjusted in three stages (modes 1, 2, and 3 in descending order of output).
  • each of the temples 6 on both sides is provided with a water holding portion 16, a sponge impregnated with 0.3 mL of water is put into the water holding portion 16.
  • the water holding portion 16 is provided with a resistance heating element 17 different from the resistance heating elements 12A on both the left and right sides, so that it can be controlled independently of the resistance heating elements 12A.
  • the resistance heating element 17 used had a resistance of 75 ⁇ and was placed in the water holding portion 16 .
  • FIG. 21 is a graph showing dry eye results based on the Dry Eye Questionnaire (OSDI).
  • OSDI Dry Eye Questionnaire
  • Fig. 22 shows the results of tear film break-up time (BUT) measured in the same time series as above. BUT was measured by instilling about 1 ⁇ L of a fluorescein staining solution (0.5%) into the eye and measuring the time until the tear film was destroyed (the average value of three times was measured as an integer). A comparison of the OSDI:1 results with the OSDI:2 and OSD:3 results showed longer tear breakup times.
  • FIG. 23 is an external view of the glasses-type device used in Experiment 9.
  • FIG. 24A and 24B are explanatory diagrams of the installation form of the resistance heating element of the spectacle-type device of FIG. 23, FIG. ) is an enlarged view thereof.
  • This spectacles-type device is slightly different from the spectacles-type device used in Experiments 3 and 8 in that it does not have a heat transfer body placed on the lower side (lower rim) of the frame frame, and is installed at a lateral position just beside the cornea.
  • the cornea is warmed by the attached resistance heating element, and a protector structure is provided to prevent the user from accidentally touching the resistance heating element.
  • the visible resistive heating element is the exposed area where the heated air is directed toward the cornea.
  • the black part around it is designed to surround the resistance heating element, and has a protector structure to prevent the user from accidentally touching the hot resistance element.
  • the lens was removed only from the right eye of the glasses-type device, and the transparent sheet was cut into a frame shape and attached with tape so that it could be opened when measuring the corneal temperature.
  • Two resistance heating elements with a resistance of 300 ⁇ were connected in parallel as the heating elements arranged on the left and right sides, respectively, so that 17 mA flowed when 5 V was applied. These heating elements are configured so that the output (temperature control) can be adjusted in three stages (modes 1, 2, and 3 in descending order of output). This experiment was conducted in mode 3, which is the strongest. Although each of the temples 6 on both sides is provided with a water holding portion, water is not supplied and humidity is not controlled.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)

Abstract

Fournir un dispositif de chauffage de cornée qui est apte à diffuser de manière sûre, directe et efficace de la chaleur sur les cornées par rayonnement thermique directionnel ou transfert de chaleur sans interférer avec la vision (en particulier, le champ de vision).　Dispositif (1) permettant de soulager la douleur et/ou d'améliorer l'œil sec par chauffage des cornées (20) avec des éléments chauffants (12). Les éléments chauffants (12) sont chacun au moins un élément choisi parmi : un élément chauffant résistif (12A) et un corps de transfert de chaleur (13) ; et un élément de rayonnement infrarouge (12B). Les éléments chauffants (12) sont chacun conçus pour être disposés à distance des cornées (20) d'une distance (L) comprise entre 10 et 60 mm, à des positions (A) vers l'avant mais également vers le bas des cornées respectives, à des positions (B) latérales par rapport auxdites positions vers le bas et vers l'avant, ou à des positions (B) latérales par rapport aux cornées respectives (20). Le dispositif de chauffage de cornée (1) est d'un type choisi parmi : un type lunettes (1A) fourni à des lunettes utilisées quotidiennement ; un type lunettes à fixation (1B) qui peut être fixé à des lunettes utilisées quotidiennement ; des types lunettes fonctionnelles, AR, VR et MR (1C) ; un type couvre œil avant (1D) ; et un type crochet auriculaire (1E).
PCT/JP2022/048711 2021-12-31 2022-12-30 Dispositif de chauffage de cornées Ceased WO2023127975A1 (fr)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12029688B1 (en) 2023-06-30 2024-07-09 David Michael Frank Heated goggle device
CN118892619A (zh) * 2024-07-11 2024-11-05 西安医学院 可湿敷热敷的红光理疗护理设备、湿敷液及其制备方法

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Publication number Priority date Publication date Assignee Title
WO2016080338A1 (fr) * 2014-11-17 2016-05-26 三井化学株式会社 Dispositif de thermothérapie
JP2017505657A (ja) * 2014-01-10 2017-02-23 マーシオ マーク アブリュー Ａｂｒｅｕ脳トンネルでモニタして治療を提供するデバイス
KR101778114B1 (ko) * 2016-07-08 2017-09-26 울산과학기술원 휴대용 전기히터장치
WO2018221687A1 (fr) * 2017-05-31 2018-12-06 株式会社坪田ラボ Dispositif et procédé de pulvérisation de brume d'humidité
WO2020080354A1 (fr) * 2018-10-15 2020-04-23 田辺三菱製薬株式会社 Appareil d'analyse d'électroencéphalogramme, système d'analyse d'électroencéphalogramme et programme d'analyse d'électroencéphalogramme
CN112138245A (zh) * 2020-09-27 2020-12-29 北京医院 一种自我反馈止痛系统

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017505657A (ja) * 2014-01-10 2017-02-23 マーシオ マーク アブリュー Ａｂｒｅｕ脳トンネルでモニタして治療を提供するデバイス
WO2016080338A1 (fr) * 2014-11-17 2016-05-26 三井化学株式会社 Dispositif de thermothérapie
KR101778114B1 (ko) * 2016-07-08 2017-09-26 울산과학기술원 휴대용 전기히터장치
WO2018221687A1 (fr) * 2017-05-31 2018-12-06 株式会社坪田ラボ Dispositif et procédé de pulvérisation de brume d'humidité
WO2020080354A1 (fr) * 2018-10-15 2020-04-23 田辺三菱製薬株式会社 Appareil d'analyse d'électroencéphalogramme, système d'analyse d'électroencéphalogramme et programme d'analyse d'électroencéphalogramme
CN112138245A (zh) * 2020-09-27 2020-12-29 北京医院 一种自我反馈止痛系统

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12029688B1 (en) 2023-06-30 2024-07-09 David Michael Frank Heated goggle device
CN118892619A (zh) * 2024-07-11 2024-11-05 西安医学院 可湿敷热敷的红光理疗护理设备、湿敷液及其制备方法

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