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WO2023108316A1 - Dispositif de distribution d'atomisation visuelle précise portable basé sur la technologie des ondes acoustiques de surface - Google Patents

Dispositif de distribution d'atomisation visuelle précise portable basé sur la technologie des ondes acoustiques de surface Download PDF

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Publication number
WO2023108316A1
WO2023108316A1 PCT/CN2021/137345 CN2021137345W WO2023108316A1 WO 2023108316 A1 WO2023108316 A1 WO 2023108316A1 CN 2021137345 W CN2021137345 W CN 2021137345W WO 2023108316 A1 WO2023108316 A1 WO 2023108316A1
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WO
WIPO (PCT)
Prior art keywords
atomization
delivery device
drug
single crystal
drug delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2021/137345
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English (en)
Chinese (zh)
Inventor
刘子俊
刘欣安
王立平
陈祖昕
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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Priority to PCT/CN2021/137345 priority Critical patent/WO2023108316A1/fr
Publication of WO2023108316A1 publication Critical patent/WO2023108316A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators

Definitions

  • the invention relates to a portable, precise and visualized atomization delivery device based on surface acoustic wave technology.
  • Nebulization therapy is an important clinical treatment for various respiratory diseases. Nebulizing inhalation device is the key equipment of respiratory system drug delivery route. Due to the increasingly serious air pollution, the living air quality is getting worse and worse, and there are more and more patients with rhinitis and lung diseases. Some neurological diseases, including the recent inhaled new crown vaccine, generally require nebulization treatment, which is mainly through The compression nebulizer atomizes the liquid drug solution, allowing people to inhale the drug through normal breathing, and enter the respiratory tract, lungs and other diseased parts during the patient's breathing process, and finally achieve the goal of painless, rapid and effective treatment.
  • the current atomization therapy device cannot achieve accurate quantitative atomization, the liquid atomization effect is poor, and the spray droplets are large and uneven. It is difficult to achieve precise and stable fluid atomization and precise adjustment of mist administration.
  • Ultrasonic atomization plays an important role in eliminating inflammation, relieving bronchospasm, and improving ventilation.
  • the ultrasonic atomization equipment used in clinical medicine is large in size and is not easy to carry or transport;
  • the required power is large, the aerosol particles generated during atomization have a large diameter range and uneven distribution, and the heat generated during atomization is large, which easily causes the liquid to be atomized to evaporate.
  • the liquid to be atomized is a drug solvent, there will be a problem of drug precipitation.
  • the present invention proposes a portable, precise and visualized atomization delivery device based on surface acoustic wave technology.
  • Drugs can produce quantitative, uniform and stable atomization through surface acoustic wave technology.
  • the unique display and control panel can independently realize the control of the atomization amount and atomization particle size, conveniently and intuitively observe the dosage and adjust the dosage to complete the control of the device.
  • the technical solution of the present invention to solve the above problems is: a portable accurate and visualized atomization delivery device based on surface acoustic wave technology, which is special in that:
  • An atomization chamber is provided inside the housing, the upper part of the atomization chamber is connected to the breathing mask, and the lower part is connected to the air intake pipe;
  • the drug delivery device includes a drug storage part, and the drug storage part includes a storage bottle, a drug delivery valve, and a drug delivery tube;
  • the atomization chip is used to atomize the drug liquid released by the drug delivery device, including a piezoelectric single crystal substrate, an interdigital transducer, a PCB circuit board and a signal interface arranged on the piezoelectric single crystal substrate ;
  • the piezoelectric single crystal substrate and the signal interface are located on the PCB circuit board, and the signal interface is connected to the interdigital transducer and the radio frequency signal generating device;
  • the drug delivery tube of the drug delivery device is attached to the upper surface of the piezoelectric single crystal substrate, and the interdigital transducer is driven by a radio frequency signal to generate a surface acoustic wave on the upper surface of the piezoelectric single crystal substrate, so that the piezoelectric The liquid on the upper surface of the single crystal substrate is atomized.
  • a breathing detector and a control processor are also included;
  • the drug delivery valve is connected to the control processor, and the control processor outputs an opening signal or a closing signal to the drug delivery valve, and the drug delivery valve is opened or closed according to the opening signal or the closing signal;
  • the control processor outputs a decrease signal or an increase signal to the dosing valve, and the dosing valve decreases or increases the dosing amount of a preset proportion according to the decrease signal or the increase signal;
  • the respiration detector is used to detect the respiration value and output it to the control processor; the control processor sends the detected current respiration value to the The dosing valve outputs an increase signal or a decrease signal.
  • an LED display screen is provided on the housing; the LED display screen is connected to the control processor, and it is used to output setting data to the control processor and display the data output by the control processor; the device Certain data include the amount of medication used.
  • the housing is provided with a manipulation panel for controlling the equipment.
  • a charging port is provided on the housing; the charging port is connected to a built-in power supply.
  • the adjustment of the interdigital transducer can adjust the atomization rate of the liquid on the upper surface of the piezoelectric single crystal substrate according to the radio frequency signal power of the loaded radio frequency signal generating device.
  • a flow meter is provided on the medicine outlet pipe for measuring the amount of medicine used.
  • an air pump is also included, the air inlet of the air pump is connected with the air inlet pipe, and the air outlet of the air pump is connected with the atomization chamber.
  • the breathing mask is detachably connected to the atomization chamber, and the air pump is controlled by a control processor.
  • the particle size of the aerosol generated during atomization is smaller and the particles are more uniform.
  • the efficiency of lung drug therapy reaches the maximum, and it is convenient for users to inhale into the lower part of the respiratory tract or lungs, depositing Therefore, these monodisperse micron-sized spray droplets are extremely useful as drug-carrying vehicles for pulmonary drug delivery.
  • the excitation frequency is 10kHz to 1MHz, which is higher than the frequency required for ultrasonic atomization.
  • the power is at most the ultrasonic atomizer using the Langevin vibrator and the one-way zirconium titanate 1/10 of the power required by the component piston nebulizer, suitable for medical and clinical applications.
  • the heat generated on the surface of the piezoelectric single crystal substrate is less, and the problem of drug precipitation is not easy to occur.
  • the atomization technology does not require nozzles or orifices, the device is simplified, and the cost is lower than other atomization technologies and the reliability is increased.
  • Fig. 1 is a schematic diagram of the present invention
  • Fig. 2 is a schematic diagram of the internal structure of the present invention.
  • Fig. 3 is a schematic structural diagram of the atomization chip in Fig. 1 .
  • SAW Surface acoustic wave
  • the present invention proposes a portable accurate and visualized atomization delivery device based on surface acoustic wave technology, including a housing 1, an atomization chip 2, and a drug delivery device.
  • the casing 1 is provided with an atomizing chamber 3 , the upper part of the atomizing chamber 3 is connected to the breathing mask 4 , and the lower part is connected to the air intake pipe 5 .
  • the drug delivery device includes a drug storage part, and the drug storage part includes a storage bottle 6 , a drug delivery valve 7 and a drug delivery tube 8 .
  • the atomizing chip 2 is connected with the drug outlet tube 8 for atomizing the drug solution released by the drug delivery device.
  • the atomizing chip 2 includes a piezoelectric single crystal substrate 9, and an interdigital transducer 10, a PCB circuit board 11 and a signal interface 12 arranged on the piezoelectric single crystal substrate 9; Electric single crystal matrix 9 and signal interface 12 are arranged on described PCB circuit board 11, and described signal interface 12 connects interdigital transducer 10 and radio frequency signal generator 20; On the upper surface of the piezoelectric single crystal substrate 9, the interdigital transducer 10 is driven by a radio frequency signal to generate a surface acoustic wave on the upper surface of the piezoelectric single crystal substrate 9, so that the liquid on the upper surface of the piezoelectric single crystal substrate 9 Fogging occurs.
  • the technical principle of the present invention is: when the SAW excited by the interdigital transducer of the atomization chip is in contact with the microfluid placed on the side of the piezoelectric substrate, the energy carried by the SAW will diffract into it at a specific angle in the form of a surface acoustic wave.
  • the liquid produces an acoustic flow coupling effect and forms capillary waves on the surface of the microfluid.
  • the inertial force accumulated by the surface capillary wave is sufficient to overcome the surface tension and viscous force of the microfluid itself, atomization begins to occur. Due to the higher frequency of SAW, the spray droplets produced will be smaller and more uniform. Ideal for generating micron-sized droplets without any moving parts or nozzles.
  • the device of the present invention further includes a breathing detector 13 and a control processor 14 .
  • the drug delivery valve 7 is connected to the control processor 14, and the control processor 14 outputs an opening signal or a closing signal to the drug delivery valve 7, and the drug delivery valve 7 is opened or closed according to the opening signal or the closing signal ;
  • the control processor 14 outputs a reduction signal or an increase signal to the drug delivery valve 7, and the drug delivery valve 7 reduces the dosage of the preset ratio or increases the preset ratio according to the reduction signal or the increase signal
  • the amount of medicine administered; the respiration detector 13 is used to detect the respiration value and output it to the control processor 14; the control processor 14 corresponds to the detected
  • the current respiratory volume value outputs an increase signal or a decrease signal to the dosing valve 7 .
  • the housing 1 is provided with an LED display screen 15; the LED display screen 15 is connected with the control processor 14, and it is used to output Set the data and display the data output by the control processor 14; the set data includes the usage amount of the medicine.
  • the housing 1 is provided with a control panel 17 for controlling the opening and closing of the device.
  • the housing 1 is provided with a charging port 18; the charging port 18 is connected to a built-in power supply 19, and the built-in power supply 19 enables the device to be carried outside.
  • the piezoelectric single crystal substrate 9 realizes continuous atomization of the liquid.
  • adjusting the interdigital transducer 10 according to the RF signal power of the loaded RF signal generating device 20 can adjust the liquid atomization rate on the upper surface of the piezoelectric single crystal substrate 9 .
  • the medicine outlet pipe 8 is provided with a flow meter 21 for measuring the amount of medicine used.
  • the value measured by the flow meter 21 is directly displayed on the LED display screen 15 .
  • an air pump 22 is also included, the air inlet of the air pump 22 is connected to the air inlet pipe 5 , and the air outlet of the air pump 22 is connected to the atomizing chamber 3 .
  • the air pump 22 provides pressure to the incoming air, so that the air enters the atomizing chamber 3 under pressure, and the atomized medicine is sent into the breathing mask 4 .
  • the breathing mask 4 is detachably connected to the atomization chamber 3 for easy replacement.
  • the air pump 22 is controlled by the control processor 14, and the air pump 22 is turned on after the control processor 14 is turned on.
  • the breathing mask 4 is a disposable mask, which can be disassembled and processed after being used once to avoid cross-infection.
  • a portable accurate and visualized atomization delivery device based on surface acoustic wave technology includes a housing 1 , a breathing detector 13 and a control processor 14 . Inside the casing 1 is an atomizing chip 2 , a drug delivery device, and an atomizing chamber 3 . The upper part of the atomization chamber 3 is connected to the breathing mask 4, and the lower part is connected to the intake pipe 5 through the air pump 22.
  • the drug delivery device includes a drug storage part, and the drug storage part includes a storage bottle 6 , a drug delivery valve 7 and a drug delivery tube 8 .
  • the atomizing chip 2 is connected with the drug outlet tube 8 for atomizing the drug solution released by the drug delivery device.
  • the air pump 22 provides pressure to the incoming air, so that the air enters the atomizing chamber 3 under pressure, and the atomized medicine is sent into the breathing mask 4 .
  • the atomizing chip 2 includes a piezoelectric single crystal substrate 9, and an interdigital transducer 10, a PCB circuit board 11 and a signal interface 12 arranged on the piezoelectric single crystal substrate 9; Electric single crystal matrix 9 and signal interface 12 are arranged on described PCB circuit board 11, and described signal interface 12 connects interdigital transducer 10 and radio frequency signal generator 20; On the upper surface of the piezoelectric single crystal substrate 9, the interdigital transducer 10 is driven by a radio frequency signal to generate a surface acoustic wave on the upper surface of the piezoelectric single crystal substrate 9, so that the liquid on the upper surface of the piezoelectric single crystal substrate 9 Fogging occurs.
  • the drug delivery valve 7 is connected to the control processor 14, and the control processor 14 outputs an opening signal or a closing signal to the drug delivery valve 7, and the drug delivery valve 7 is opened or closed according to the opening signal or the closing signal ;
  • the control processor 14 outputs a reduction signal or an increase signal to the drug delivery valve 7, and the drug delivery valve 7 reduces the dosage of the preset ratio or increases the preset ratio according to the reduction signal or the increase signal
  • the amount of medicine administered; the respiration detector 13 is used to detect the respiration value and output it to the control processor 14; the control processor 14 corresponds to the detected
  • the current respiratory volume value outputs an increase signal or a decrease signal to the dosing valve 7 .
  • adjusting the interdigital transducer 10 according to the RF signal power of the loaded RF signal generating device 20 can adjust the liquid atomization rate on the upper surface of the piezoelectric single crystal substrate 9 .
  • the side of the housing 1 is provided with an LED display 15 and a control panel 17 , and a charging port 18 is provided on the lower side.
  • the LED display screen 15 is connected with the control processor 14, and it is used to output setting data to the control processor 14 and display the data output by the control processor 14; the setting data includes the usage amount of the medicine.
  • the control panel 17 is used to control the opening and closing of the equipment.
  • the charging port 18 is connected to a built-in power supply 19, and the built-in power supply 19 enables the device to be carried outside.
  • a flow meter 21 is provided on the medicine outlet pipe 8 for measuring the amount of medicine used. The value measured by the flow meter 21 is directly displayed on the LED display screen 15 .
  • the breathing mask 4 is detachably connected to the atomization chamber 3, which is convenient for replacement.
  • the air pump 22 is controlled by the control processor 14, and the air pump 22 is turned on after the control processor 14 is turned on.
  • the breathing mask 4 is a disposable mask, which can be disassembled and processed after being used once to avoid cross-infection.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Special Spraying Apparatus (AREA)

Abstract

L'invention concerne un dispositif de distribution d'atomisation visuelle précise portable basé sur une technologie d'ondes acoustiques de surface, comprenant un boîtier (1), une puce d'atomisation (2) et un appareil de distribution de médicament. Une cavité d'atomisation (3) est disposée dans le boîtier (1), et la cavité d'atomisation (3) a la partie supérieure reliée à un masque respiratoire (4), et la partie inférieure reliée à un tuyau d'entrée d'air (5) ; l'appareil de distribution de médicament comprend une partie de stockage de médicament, la partie de stockage de médicament comprenant une bouteille de stockage (6), une valve de distribution de médicament (7), et un tuyau de sortie de médicament (8) ; la puce d'atomisation (2) est utilisée pour atomiser un médicament liquide libéré par l'appareil de distribution de médicament, et comprend un substrat monocristallin piézoélectrique (9), un transducteur interdigité (10) disposé sur le substrat monocristallin piézoélectrique (9), une PCB (11) et une interface de signal (12). Un médicament peut générer une atomisation quantitative, uniforme et stable au moyen d'une technologie à ondes acoustiques de surface, un utilisateur peut commander de manière autonome une quantité d'atomisation et une taille de particule d'atomisation au moyen d'un dispositif d'affichage externe et d'un panneau de commande, ce qui facilite l'observation visuelle du dosage et règle le dosage pour commander l'appareil.
PCT/CN2021/137345 2021-12-13 2021-12-13 Dispositif de distribution d'atomisation visuelle précise portable basé sur la technologie des ondes acoustiques de surface Ceased WO2023108316A1 (fr)

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PCT/CN2021/137345 WO2023108316A1 (fr) 2021-12-13 2021-12-13 Dispositif de distribution d'atomisation visuelle précise portable basé sur la technologie des ondes acoustiques de surface

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PCT/CN2021/137345 WO2023108316A1 (fr) 2021-12-13 2021-12-13 Dispositif de distribution d'atomisation visuelle précise portable basé sur la technologie des ondes acoustiques de surface

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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1330563A (zh) * 1998-12-18 2002-01-09 欧姆龙株式会社 喷雾装置
CN102458684A (zh) * 2009-05-11 2012-05-16 莫纳什大学 用于液体雾化的微流体设备
CN102985190A (zh) * 2010-11-11 2013-03-20 株式会社赛勒芙特 雾化装置
US20160001316A1 (en) * 2013-03-01 2016-01-07 Rmit University Atomisation apparatus using surface acoustic wave generation
CN106174706A (zh) * 2016-08-31 2016-12-07 云南中烟工业有限责任公司 一种声表面波雾化器
CN107297004A (zh) * 2017-08-23 2017-10-27 苏州浩哥文化传播有限公司 一种智能调整输出量的雾化治疗设备
CN107376070A (zh) * 2017-07-17 2017-11-24 太仓秦风广告传媒有限公司 一种便携式定量释放的雾化治疗仪
CN109011043A (zh) * 2018-08-01 2018-12-18 哈尔滨工业大学（深圳） 一种基于声表面波的雾化装置和方法
WO2021059923A1 (fr) * 2019-09-26 2021-04-01 パナソニックＩｐマネジメント株式会社 Système d'atomisation de liquide, système de génération de brume et procédé d'atomisation de liquide

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1330563A (zh) * 1998-12-18 2002-01-09 欧姆龙株式会社 喷雾装置
CN102458684A (zh) * 2009-05-11 2012-05-16 莫纳什大学 用于液体雾化的微流体设备
CN102985190A (zh) * 2010-11-11 2013-03-20 株式会社赛勒芙特 雾化装置
US20160001316A1 (en) * 2013-03-01 2016-01-07 Rmit University Atomisation apparatus using surface acoustic wave generation
CN106174706A (zh) * 2016-08-31 2016-12-07 云南中烟工业有限责任公司 一种声表面波雾化器
CN107376070A (zh) * 2017-07-17 2017-11-24 太仓秦风广告传媒有限公司 一种便携式定量释放的雾化治疗仪
CN107297004A (zh) * 2017-08-23 2017-10-27 苏州浩哥文化传播有限公司 一种智能调整输出量的雾化治疗设备
CN109011043A (zh) * 2018-08-01 2018-12-18 哈尔滨工业大学（深圳） 一种基于声表面波的雾化装置和方法
WO2021059923A1 (fr) * 2019-09-26 2021-04-01 パナソニックＩｐマネジメント株式会社 Système d'atomisation de liquide, système de génération de brume et procédé d'atomisation de liquide

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