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WO2023184597A1 - Cœur simulé, dispositif de simulation de cœur et procédé de simulation de cœur - Google Patents

Cœur simulé, dispositif de simulation de cœur et procédé de simulation de cœur Download PDF

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Publication number
WO2023184597A1
WO2023184597A1 PCT/CN2022/087071 CN2022087071W WO2023184597A1 WO 2023184597 A1 WO2023184597 A1 WO 2023184597A1 CN 2022087071 W CN2022087071 W CN 2022087071W WO 2023184597 A1 WO2023184597 A1 WO 2023184597A1
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WIPO (PCT)
Prior art keywords
valve
heart
simulated
simulated heart
liquid
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PCT/CN2022/087071
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English (en)
Chinese (zh)
Inventor
彭钰楠
胡冠彤
张立炜
王贝西
彭胡
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    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • G09B23/30—Anatomical models

Definitions

  • the invention belongs to the field of heart valve biomechanics research and the field of cardiac surgery, and specifically relates to a simulated heart, a heart simulation device and a heart simulation method.
  • heart valve biomechanics The field of heart valve biomechanics is a rapidly expanding research area that is highly clinically relevant. Although most valvular pathologies have their roots in biomechanical changes, the technology to study these lesions and determine treatments is largely limited. However, significant progress has been made in this area to better understand heart valve biomechanics, pathology, and interventional therapies, driven primarily by key in silico, in vitro, and in vivo modeling techniques. These techniques have yielded new insights into relevant native, disease, and repair physiology, but each development has unique advantages and limitations. These studies use creative, interdisciplinary approaches to recreate in vivo physiology, which has transformed clinical understanding and practice in cardiovascular surgery.
  • the advantage of Professor Y. Joseph Woo's invention is that it can simulate the hemodynamic characteristics of the four chambers of the heart (left ventricle, right ventricle, left atrium, right atrium), and at the same time, a papillary muscle simulation device is built into the simulator. , and then simulate the dynamic changes of hemodynamics under the condition of valve opening and closing.
  • the shortcomings are also very obvious. Because it basically stays at the laboratory prototype stage, it uses a regular cavity structure to simulate the chambers of the heart. Its internal and external structures do not have the 1:1 structure of the real heart, which results in the data generated by its simulation being very different from the real human heart data. Far. It does not have the conditions for clinical and large-scale laboratory research. In addition, because its internal and external structures are relatively regular, it cannot simulate the conditions after intracardiac thrombosis.
  • Ventricular simulator developed by a research team led by Professor Ajit P. Yoganathan.
  • the in vitro simulator they created does not have a complete four-chamber heart, but a structure pieced together from two relatively simple cylinders, which is then used for the atrium and ventricle structure of one side.
  • the research point also has a movable papillary muscle structure to simulate the valve opening and closing movement during heart contraction.
  • this structure can also be equipped with real valves to simulate the impact of real valves on intracardiac hemodynamics to a greater extent.
  • the present invention proposes a simulated heart, a heart simulation device and a heart simulation method, which overcome the problems of the existing technology and have practical clinical significance.
  • a simulated heart including:
  • the simulated heart body includes an upper part containing simulated left and right atria, a middle part and a lower part containing left and right ventricles.
  • the upper part, the middle part and the lower part are connected together in sequence.
  • the middle part includes a middle part body and a valve assembly.
  • the valve assembly includes a valve mounting structure and a valve.
  • the body and valves of the middle part, or the entire middle part are prepared using 3D printing technology based on the three-dimensional model data of the actual heart.
  • the simulated heart is divided into the upper part, the middle part and the lower part and prepared separately, so that the simulated heart that is modeled based on the three-dimensional data of the actual heart and then 3D printed has the feasibility of being studied as a simulated heart.
  • the present invention creatively divides the simulated heart into upper, middle and lower parts to facilitate the installation and replacement of each valve (tricuspid valve, pulmonary valve , aortic valve and mitral valve), and the installation of each valve opening and closing drive device, so that the simulated heart can replicate the actual structure of the actual heart (such as the heart of a certain patient or an animal) and simulate its operating characteristics as much as possible , making the simulated heart possible for clinical use.
  • each valve tricuspid valve, pulmonary valve , aortic valve and mitral valve
  • each valve opening and closing drive device so that the simulated heart can replicate the actual structure of the actual heart (such as the heart of a certain patient or an animal) and simulate its operating characteristics as much as possible , making the simulated heart possible for clinical use.
  • the structural differences between the upper part and the lower part respectively corresponding to the upper part of the left and right atrium and the lower part of the left and right ventricle are small, these differences have a small impact on intracardiac hemodynamics.
  • the upper part is The upper and lower parts can also adopt a common structure. Therefore, only the middle part needs to be modeled and 3D printed according to the three-dimensional data of a specific heart, and sealed and connected with the universal upper and lower parts to well simulate the intracardiac hemodynamic model of a specific heart. .
  • valve installation structure is an annular structure, the outer peripheral edge is sealingly connected or integrally formed with the inner wall of the middle part body, and the inner peripheral edge is provided with a valve installation part; the valve is detachably installed on the valve installation structure through the valve installation part superior.
  • the technical solution of the present invention can use 3D printing technology to restore or highly approximate the human heart or the heart of other mammals (such as mice, pigs, etc.) in a 1:1 manner. Fully simulates the complex internal structures of the four cardiac chambers, providing a structural basis for simulating intracardiac thrombosis.
  • the present invention also provides a detachable valve modular design, which can meet the individual differences of different clinical patients and help clinicians perform preoperative surgical rehearsals and predict postoperative adverse events.
  • valve mounting part is a C-shaped annular groove
  • a connecting part is provided on the outer periphery of the valve
  • the connecting part is embedded in the C-shaped annular groove
  • the cross-section of the C-shaped annular groove is a pentagon
  • the opening connection line is one of the sides
  • the two sides away from the opening intersect and the included angle is an acute angle
  • the shape of the connecting part is consistent with the C-shaped annular groove. Structural adaptation of grooves.
  • valve clamps are provided circumferentially along the edge of the C-shaped annular groove.
  • the valve clamp has a pentagonal cross-section with an opening.
  • the connecting line of the opening is one of the sides, and the two valve clamps are away from the opening.
  • the edges intersect and the included angle is an acute angle, and the shape of the connecting portion is adapted to the structure of the valve clip.
  • valve assembly also includes a valve opening and closing driving device.
  • the valve opening and closing driving device includes a power component and a traction mechanism. One end of the traction mechanism is drivingly connected to the power component, and the other end is connected to the valve installation structure or the valve.
  • the traction mechanism The reciprocating motion of the mechanism drives the valve to open or reset and close.
  • a through hole is provided on the side wall of the middle part body;
  • the traction mechanism includes a pulling cable and an elastic or telescopic sheath wrapping the pulling cable; one end of the pulling cable is connected to the power element, and the other end passes through
  • the through hole is connected to the valve installation structure or the valve; one end of the sheath is sealingly connected to the outer wall of the middle part of the circumference of the through hole, and the other end is slidingly and sealingly connected to the pull cable, or is sealingly connected to the shell of the power component, while the power component is connected to the pulley Cable sliding seal connection.
  • the pull cable is an elastic or rigid filamentary element
  • the valve mounting part is provided with a first pull cable connection part
  • the front end of the pull cable is provided with a second pull cable that is adapted to the first pull cable connection part. Cable connection part.
  • the present invention also provides a heart simulation device.
  • the shape simulation device includes any of the above-mentioned simulated hearts, and also includes a blood circulation simulation device.
  • the blood circulation simulation device includes a liquid delivery pump, a liquid storage box and a plurality of connections. pipeline, one end of the connecting pipeline is connected to the aorta, main vein, pulmonary artery and pulmonary vein of the simulated heart respectively, and the other end is connected to the liquid transfer pump and the liquid storage box respectively.
  • the liquid transfer pump drives the liquid in the liquid storage box through the connection Tubing enters and exits the simulated heart, and the flow of fluid in the simulated heart is consistent with that of an actual heart.
  • the invention also provides a heart simulation method, which includes the following steps:
  • This invention can 3D print a 1:1 model of the middle part of the patient's heart valve before the patient undergoes heart surgery (especially heart valve disease), install the personalized printed heart valve to the middle part body, and then install the middle part
  • the fluorescent liquid is pumped into the simulator driven by a device such as the Vivitro plus, and the valve opens and closes under the drive of the valve opening and closing driving device (movable papillary muscle simulator). Then simulate the real intracardiac hemodynamics.
  • Figure 1 is a schematic diagram of a simulated heart according to the present invention.
  • FIG. 2 is a schematic diagram of the valve of the present invention.
  • Figure 3 is a schematic diagram of the valve installation structure of the present invention.
  • Figure 4 is a schematic diagram of the valve and valve mounting structure assembled together.
  • a simulated heart includes:
  • the simulated heart body includes an upper part 1 containing the simulated left and right atria, a middle part 2, and a lower part 3 containing the left and right ventricles.
  • the upper part 1, the middle part 2, and the lower part 3 are connected together in sequence to form a complete heart structure.
  • the middle part includes a middle part body and a valve assembly, and the valve assembly includes a valve mounting structure 21 and a valve 22 .
  • the middle portion contains four valve components, namely tricuspid valve 7, pulmonary valve 6, aortic valve 8, and mitral valve 9.
  • the middle part body and valve, or the middle part are all prepared using 3D printing technology based on the three-dimensional model data of the actual heart.
  • the simulated heart is divided into the upper part, the middle part and the lower part and prepared separately, so that the simulated heart that is modeled based on the three-dimensional data of the actual heart and then 3D printed has the feasibility of being studied as a simulated heart.
  • the present invention creatively divides the simulated heart into upper, middle and lower parts to facilitate the installation and replacement of each valve (tricuspid valve, pulmonary valve , aortic valve and mitral valve), and the installation of each valve opening and closing drive device, so that the simulated heart can replicate the actual structure of the actual heart (such as the heart of a certain patient or an animal) and simulate its operation as much as possible
  • the simulated heart can replicate the actual structure of the actual heart (such as the heart of a certain patient or an animal) and simulate its operation as much as possible
  • the structural differences between the upper part and the lower part respectively corresponding to the upper part of the left and right atrium and the lower part of the left and right ventricle are small, these differences have a small impact on intracardiac hemodynamics.
  • the upper part is The upper and lower parts can also adopt a common structure. Therefore, only the middle part needs to be modeled and 3D printed according to the three-dimensional data of a specific heart, and sealed and connected with the universal upper and lower parts to well simulate the intracardiac hemodynamic model of a specific heart. .
  • the valve installation structure 21 is an annular structure, and the middle through hole 212 is used to install the valve 22; the outer peripheral edge is sealed or integrally formed with the inner wall of the middle part body, and the inner peripheral edge is provided with a valve installation portion 213;
  • the valve 22 is detachably mounted on the valve mounting structure 21 through the valve mounting portion 213 .
  • the valve has an annular connecting portion 221.
  • In the middle of the connecting portion 221 is a valve body 3D printed based on solid modeling.
  • the connecting portion 221 is adapted and sealedly connected to the valve mounting portion 213.
  • the technical solution of the present invention can use 3D printing technology to restore or highly approximate the human heart or the heart of other mammals (such as mice, pigs, etc.) in a 1:1 manner. Fully simulates the complex internal structures of the four cardiac chambers, providing a structural basis for simulating intracardiac thrombosis.
  • the present invention also provides a detachable valve modular design, which can meet the individual differences of different clinical patients and help clinicians perform preoperative surgical rehearsals and predict postoperative adverse events.
  • the valve mounting portion 213 is a C-shaped annular groove, and a connecting portion 221 is provided on the outer periphery of the valve, and the connecting portion 221 is embedded in the C-shaped annular groove.
  • the cross-section of the C-shaped annular groove is a pentagon
  • the opening connection line is one of the sides
  • the two sides away from the opening intersect and the included angle is an acute angle
  • the connecting portion The shape of 221 is adapted to the structure of the C-shaped annular groove (valve mounting portion 213).
  • valve clamps are provided circumferentially along the edge of the C-shaped annular groove (valve mounting portion 213).
  • the valve clamp is a pentagonal structure with an opening, and the connecting line of the openings is One of the sides, two sides away from the opening intersect, and the included angle is an acute angle.
  • the shape of the connecting portion 221 is adapted to the structure of the valve clip. In this way, the structure of the C-shaped annular groove can undergo various structural deformations according to the needs of sealing.
  • the valve assembly also includes a valve opening and closing driving device.
  • the valve opening and closing driving device includes a power component 5 and a traction mechanism. One end of the traction mechanism is drivingly connected to the power component 5, and the other end is connected to the power component 5.
  • the valve installation structure 21 or the valve 22 are connected, and the reciprocating motion of the traction mechanism drives the valve 22 to open or reset and close.
  • a through hole is provided on the side wall of the middle part body; the traction mechanism includes a pulling cable 41 and an elastic or telescopic sheath 42 wrapping the pulling cable; one end of the pulling cable 41 is connected to a power source The other end of the element 5 passes through the through hole and is connected to the valve installation structure 21 or the valve 22 (generally it is preferred to connect to the valve installation structure 21, because it is more convenient to set the hooking structure 211 connected to the pull cable 41 on the valve installation structure 21, and it is more convenient for the blood.
  • one end 421 of the sheath 42 is sealingly connected to the outer wall of the middle part of the circumference of the through hole, and the other end 422 is connected to the cable sliding seal or fixed sealing, or to the shell of the power component, and at the same time
  • the power component 5 is connected with the cable 41 in a sliding and sealing manner.
  • the power element 5 drives the cable to reciprocate, and the actual reciprocating distance is at the millimeter level, which can drive the opening and closing of the valve 22 and is similar to the actual heart.
  • the pulling cable 41 can be selected as an elastic or rigid filamentary element.
  • a first pulling cable connection part 211 is provided on the outside of the membrane valve mounting part 213. The front end of the pulling cable 41 is provided with a first pulling cable connecting part 211.
  • the cable connection part 213 is adapted to the second cable connection part.
  • the present invention also provides a heart simulation device.
  • the shape simulation device includes any of the above-mentioned simulated hearts, and also includes a blood circulation simulation device.
  • the blood circulation simulation device includes a liquid delivery pump, a liquid storage box and a plurality of connections. pipeline, one end of the connecting pipeline is connected to the aorta, main vein, pulmonary artery and pulmonary vein of the simulated heart respectively, and the other end is connected to the liquid transfer pump and the liquid storage box respectively.
  • the liquid transfer pump drives the liquid in the liquid storage box through the connection Tubing enters and exits the simulated heart, and the flow of fluid in the simulated heart is consistent with that of an actual heart.
  • the invention also provides a heart simulation method, which includes the following steps:
  • This invention can 3D print a 1:1 model of the middle part of the patient's heart valve before the patient undergoes heart surgery (especially heart valve disease), install the personalized printed heart valve to the middle part body, and then install the middle part
  • the fluorescent liquid is pumped into the simulator driven by a device such as the Vivitro plus, and the valve opens and closes under the drive of the valve opening and closing driving device (movable papillary muscle simulator). Then simulate the real intracardiac hemodynamics.

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Physics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Algebra (AREA)
  • Computational Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
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  • Medical Informatics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Business, Economics & Management (AREA)
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Abstract

Un cœur simulé, un dispositif de simulation de cœur et un procédé de simulation de cœur. Le cœur simulé comprend un corps de cœur simulé qui comprend une partie supérieure (1), une partie intermédiaire (2) et une partie inférieure (3) qui sont successivement reliées, la partie intermédiaire (2) comprenant un corps de partie intermédiaire et un ensemble valvule, et l'ensemble valvule comprenant une structure de montage de valvule (21) et une valvule (22). Le cœur simulé est divisé en la partie supérieure (1), la partie intermédiaire (2) et la partie inférieure (3) qui sont préparées séparément, de telle sorte que le cœur simulé modélisé en fonction de données tridimensionnelles d'un cœur réel puis imprimé par impression 3D a le potentiel d'être utilisé comme cœur simulé pour la recherche, de façon à ce que le cœur simulé reproduise aussi fidèlement que possible une structure de cœur réelle et effectue une simulation en fonction de différentes caractéristiques cliniques de différents patients, et le cœur simulé peut faire l'objet d'une utilisation clinique.
PCT/CN2022/087071 2022-03-31 2022-04-15 Cœur simulé, dispositif de simulation de cœur et procédé de simulation de cœur Ceased WO2023184597A1 (fr)

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CN202210331550 2022-03-31

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119516881A (zh) * 2024-11-21 2025-02-25 北京航空航天大学 一种用于离体心脏体外近生理模拟的组件

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120288840A1 (en) * 2010-01-29 2012-11-15 Gurdin Jonathan M Circulatory heart model
EP2548592A1 (fr) * 2011-07-20 2013-01-23 Ihab Daoud Hanna Implant intracardiaque - cýur entièrement artificiel
CN205287050U (zh) * 2016-01-07 2016-06-08 中国十九冶集团有限公司职工医院 全肌性人工心脏
CN205943277U (zh) * 2016-05-16 2017-02-08 闫亚军 一种用于教学演示的三维模拟心脏跳动的装置
CN110974317A (zh) * 2019-11-25 2020-04-10 西安马克医疗科技有限公司 经导管二尖瓣疾病治疗手术的3d模型体外模拟装置及系统
CN210535156U (zh) * 2019-07-25 2020-05-15 甘丽娟 一种血液循环动态模型
CN112092409A (zh) * 2020-09-15 2020-12-18 清华大学深圳国际研究生院 一种心脏模型制作方法及其制作模具
CN112509444A (zh) * 2020-12-23 2021-03-16 四川大学华西医院 一种模拟心脏的跳动器

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120288840A1 (en) * 2010-01-29 2012-11-15 Gurdin Jonathan M Circulatory heart model
EP2548592A1 (fr) * 2011-07-20 2013-01-23 Ihab Daoud Hanna Implant intracardiaque - cýur entièrement artificiel
CN205287050U (zh) * 2016-01-07 2016-06-08 中国十九冶集团有限公司职工医院 全肌性人工心脏
CN205943277U (zh) * 2016-05-16 2017-02-08 闫亚军 一种用于教学演示的三维模拟心脏跳动的装置
CN210535156U (zh) * 2019-07-25 2020-05-15 甘丽娟 一种血液循环动态模型
CN110974317A (zh) * 2019-11-25 2020-04-10 西安马克医疗科技有限公司 经导管二尖瓣疾病治疗手术的3d模型体外模拟装置及系统
CN112092409A (zh) * 2020-09-15 2020-12-18 清华大学深圳国际研究生院 一种心脏模型制作方法及其制作模具
CN112509444A (zh) * 2020-12-23 2021-03-16 四川大学华西医院 一种模拟心脏的跳动器

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119516881A (zh) * 2024-11-21 2025-02-25 北京航空航天大学 一种用于离体心脏体外近生理模拟的组件

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