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WO2023177841A3 - Combination products to mitigate misuse of central nervous system stimulants - Google Patents

Combination products to mitigate misuse of central nervous system stimulants Download PDF

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Publication number
WO2023177841A3
WO2023177841A3 PCT/US2023/015455 US2023015455W WO2023177841A3 WO 2023177841 A3 WO2023177841 A3 WO 2023177841A3 US 2023015455 W US2023015455 W US 2023015455W WO 2023177841 A3 WO2023177841 A3 WO 2023177841A3
Authority
WO
WIPO (PCT)
Prior art keywords
misuse
effective amount
mitigate
nervous system
combination products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2023/015455
Other languages
French (fr)
Other versions
WO2023177841A2 (en
Inventor
Michael PRESTI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2023177841A2 publication Critical patent/WO2023177841A2/en
Publication of WO2023177841A3 publication Critical patent/WO2023177841A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A method is provided for reducing concurrent use of stimulant medications and alcohol. In an example, the method comprises administering to the subject a combination product that includes an effective amount of one or more stimulant medications, and an effective amount of one or more aldehyde dehydrogenase inhibitors (ALDIs), to provide the desired effects of the stimulant medication in conjunction with a substance that prevents or deters concurrent alcohol consumption, thereby reducing misuse of stimulant medications in combination with alcohol. Also disclosed are the combination products that include the effective amount of one or more stimulant medications and the effective amount of one or more ALDIs.
PCT/US2023/015455 2022-03-18 2023-03-17 Combination products to mitigate misuse of central nervous system stimulants Ceased WO2023177841A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263321221P 2022-03-18 2022-03-18
US63/321,221 2022-03-18

Publications (2)

Publication Number Publication Date
WO2023177841A2 WO2023177841A2 (en) 2023-09-21
WO2023177841A3 true WO2023177841A3 (en) 2023-10-19

Family

ID=88024197

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/015455 Ceased WO2023177841A2 (en) 2022-03-18 2023-03-17 Combination products to mitigate misuse of central nervous system stimulants

Country Status (1)

Country Link
WO (1) WO2023177841A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090281112A1 (en) * 2008-05-08 2009-11-12 Fabre-Kramer Pharmaceuticals, Inc. Adatanserin and metabolites thereof for treatment of attention deficit disorder, anxiety, depression, sexual dysfunction, and other disorders
US20100291205A1 (en) * 2007-01-16 2010-11-18 Egalet A/S Pharmaceutical compositions and methods for mitigating risk of alcohol induced dose dumping or drug abuse
US20160213628A1 (en) * 2013-09-09 2016-07-28 Nova Southeastern University Deterring abuse of pharmaceutical products and alcohol
US20190231719A1 (en) * 2018-01-26 2019-08-01 Michael Presti Combination treatments for opioid crisis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100291205A1 (en) * 2007-01-16 2010-11-18 Egalet A/S Pharmaceutical compositions and methods for mitigating risk of alcohol induced dose dumping or drug abuse
US20090281112A1 (en) * 2008-05-08 2009-11-12 Fabre-Kramer Pharmaceuticals, Inc. Adatanserin and metabolites thereof for treatment of attention deficit disorder, anxiety, depression, sexual dysfunction, and other disorders
US20160213628A1 (en) * 2013-09-09 2016-07-28 Nova Southeastern University Deterring abuse of pharmaceutical products and alcohol
US20190231719A1 (en) * 2018-01-26 2019-08-01 Michael Presti Combination treatments for opioid crisis

Also Published As

Publication number Publication date
WO2023177841A2 (en) 2023-09-21

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