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WO2023159052A3 - Stapled peptides, methods of making same, and uses thereof - Google Patents

Stapled peptides, methods of making same, and uses thereof Download PDF

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Publication number
WO2023159052A3
WO2023159052A3 PCT/US2023/062642 US2023062642W WO2023159052A3 WO 2023159052 A3 WO2023159052 A3 WO 2023159052A3 US 2023062642 W US2023062642 W US 2023062642W WO 2023159052 A3 WO2023159052 A3 WO 2023159052A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
stapled
methods
various examples
making same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2023/062642
Other languages
French (fr)
Other versions
WO2023159052A2 (en
Inventor
Qing Lin
Yifang Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transira Therapeutics LLC
Original Assignee
Transira Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transira Therapeutics LLC filed Critical Transira Therapeutics LLC
Publication of WO2023159052A2 publication Critical patent/WO2023159052A2/en
Publication of WO2023159052A3 publication Critical patent/WO2023159052A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Stapled peptides, methods of making same, and uses thereof. In various examples, a stapled peptide comprises two staples (which may be referred to as crosslinks). In various examples, a composition comprises one or more stapled peptide(s) and optionally, one or more permeation enhancer(s). In various examples, a method of making a stapled peptide comprises reacting a peptide comprising two cysteines at selected positions and two protected cysteines at selected positions with a crosslinking agent, deprotecting singly- crosslinked peptide and reacting the deprotected singly-crosslinked peptide with a crosslinking agent to form a stapled peptide comprising two staples. In various examples, a stapled peptide or stapled peptides are used in methods of lowering the glucose in an individual and/or weight loss methods.
PCT/US2023/062642 2022-02-15 2023-02-15 Stapled peptides, methods of making same, and uses thereof Ceased WO2023159052A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263310430P 2022-02-15 2022-02-15
US63/310,430 2022-02-15

Publications (2)

Publication Number Publication Date
WO2023159052A2 WO2023159052A2 (en) 2023-08-24
WO2023159052A3 true WO2023159052A3 (en) 2023-09-28

Family

ID=87579124

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/062642 Ceased WO2023159052A2 (en) 2022-02-15 2023-02-15 Stapled peptides, methods of making same, and uses thereof

Country Status (1)

Country Link
WO (1) WO2023159052A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140113857A1 (en) * 2011-04-15 2014-04-24 Dana-Farber Cancer Institute, Inc. Targeting deregulated wnt signaling in cancer using stabilized alpha-helices of bcl-9
US20170196940A1 (en) * 2015-10-30 2017-07-13 The Research Foundation For The State University Of New York Oxyntomodulin analogs and methods of making and using same
US20220000981A1 (en) * 2013-12-18 2022-01-06 The Scripps Research Institute Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140113857A1 (en) * 2011-04-15 2014-04-24 Dana-Farber Cancer Institute, Inc. Targeting deregulated wnt signaling in cancer using stabilized alpha-helices of bcl-9
US20220000981A1 (en) * 2013-12-18 2022-01-06 The Scripps Research Institute Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
US20170196940A1 (en) * 2015-10-30 2017-07-13 The Research Foundation For The State University Of New York Oxyntomodulin analogs and methods of making and using same

Also Published As

Publication number Publication date
WO2023159052A2 (en) 2023-08-24

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