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WO2023149857A1 - Système dans lequel le traitement de maladies et de troubles est réalisé par stimulation électrique de nerfs et procédé de fonctionnement pour ledit système - Google Patents

Système dans lequel le traitement de maladies et de troubles est réalisé par stimulation électrique de nerfs et procédé de fonctionnement pour ledit système Download PDF

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Publication number
WO2023149857A1
WO2023149857A1 PCT/TR2023/050071 TR2023050071W WO2023149857A1 WO 2023149857 A1 WO2023149857 A1 WO 2023149857A1 TR 2023050071 W TR2023050071 W TR 2023050071W WO 2023149857 A1 WO2023149857 A1 WO 2023149857A1
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WO
WIPO (PCT)
Prior art keywords
stimulator
stimulation
ear
current
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/TR2023/050071
Other languages
English (en)
Inventor
Ali Can ERK
Ali Veysel OZDEN
Onur Yusuf CINAR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vagustim Saglik Teknolojileri AS
Original Assignee
Vagustim Saglik Teknolojileri AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from TR2022/001477 external-priority patent/TR2022001477Y/tr
Application filed by Vagustim Saglik Teknolojileri AS filed Critical Vagustim Saglik Teknolojileri AS
Publication of WO2023149857A1 publication Critical patent/WO2023149857A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0484—Garment electrodes worn by the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/048—Electrodes characterised by a specific connection between lead and electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36034—Control systems specified by the stimulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36036—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the outer, middle or inner ear

Definitions

  • the invention relates to a system where the diseases and/or disorders are treated by electrical stimulation of the auricular vagus nerve, and to a method of operation for said system.
  • the autonomic nervous system is a system controlling all of the vital functions of the body. In other words, all of the functions of our organs that are not able to be controlled by our are managed by the autonomic nervous system.
  • the activity of the autonomic nervous system varies during the daily life, serving to enable our body to accommodate the changes in the internal and external environment.
  • the impairments in the variable activity of the autonomic nervous system lead to the impairment in the body's ability to adapt to the variables in the internal and external environment, resulting in the emergence of the autonomic dysfunction and the associated diseases.
  • Activation of the nerves by stimulation is employed for the treatment of the resulting disorders and diseases.
  • the nerves may be stimulated by sending electrical signals to various nerves from various parts.
  • the stimulation is realized via different parts of different nerves by means of the signals with different electrical properties for treating different disorders.
  • the treatment of the diseases and disorders is enabled by noninvasive electrical stimulation of the auricular vagus nerve.
  • An object of the invention is to develop a system where the treatment of the diseases and/disorders is enabled by the stimulation of the vagus nerve.
  • Another object of the invention is to develop a system where the treatment of diseases and/or disorders is enabled by the stimulation of the vagus nerve via the ear.
  • Another object of the invention is to develop a system where the treatment of diseases and/or disorders is enabled by the stimulation of the vagus nerve via both ears.
  • Another object of the invention is to develop a system where the treatment of diseases and/or disorders is enabled by the stimulation of the vagus nerve through the application of electricity to two different points of the ear.
  • Another object of the invention is to develop a system where the stimulation parameters may be set wirelessly via a mobile device or partly via the device itself.
  • Figure 1 An overall view of the system according to the invention
  • Figure 2 A view of the electrode and the electrode carrier
  • Figure 3 A view of the ear hook, the electrode and the electrode carrier
  • Figure 4 Another view of the ear hook, the electrode and the electrode carrier
  • Electrode El Electrode carrier
  • the invention relates to a system where the diseases and/or disorders are treated by electrical stimulation of the auricular vagus nerve, and to a method of operation for said system. More specifically, the invention relates to a system where the stimulation of the vagus nerve is enabled via the auricular branch of said nerve with the electrical parameters possible to be set according to the needs of the patient to thereby treat the diseases and/or disorders, and to a method of operation for said system.
  • the bilateral symmetric stimulation of the auricular vagus nerve is performed.
  • the performance of the stimulation of the auricular vagus nerve in a bilateral symmetric manner enables the efficacy to be increased. Owing to the fact that the stimulation is not applied simultaneously to both ears, the possible electric leakage between the two ears is reduced, thereby enabling the current to stay vagus-specific.
  • the symmetric sequential bilateral stimulation enhances the efficacy of the treatment.
  • This method is one of the practices preferred especially for the psychological/psychiatric disorders. Said method, which first started to be practiced in the form of EMDR (Eye Movement Desensitization and Reprocessing), was subsequently improved also for the other stimuli such as sound and touch. However, so far there is no such known application of the method for the stimulation of the auricular vagus nerve.
  • EMDR is a strong psychotherapeutic approach. Until the present, the method has enabled the successful treatment of different types of psychological disorders in about 2 million people from all ages.
  • the development of EMDR began in 1987 when Dr. Francine Shapiro accidentally discovered that the eye movements could diminish the intensity of the disturbing thoughts.
  • Dr. Shapiro conducted scientific studies about this effect in the individuals who experienced trauma and published her study demonstrating the success achieved in the treatment (Journal of Traumatic Stress, 1989).
  • the individual follows with his/her eyes the fingers of the therapist who moves his/her fingers in two directions. It is believed that a person's focusing his/her attention simultaneously on the thoughts in his/her mind and on his/her eye movements activates the relationship between the right and left cerebral hemispheres.
  • EMDR Besides the bidirectional eye movements applied in EMDR, other stimulations are also used, such as the bidirectional auditory stimulation and bidirectional touch. It was found as a result of the controlled studies that EMDR effectively reduces or eliminates the post-traumatic stress syndromes in the majority of the patients and provides relief in the symptoms (such as anxiety) generally associated with the psychological problems. EMDR is found effective also by many international health and government institutions (World Health Organization (WHO), American Psychiatric Association, International Society for Traumatic Stress Studies, U.S. Department of Veterans Affairs, U.S. Department of Defense, United Kingdom Department of Health, and Israeli National Council for Mental Health) (EMDR Society, https://www.emdr-tr.org/emdr-nedir/).
  • WHO World Health Organization
  • EMDR American Psychiatric Association
  • the mechanism of EMDR basically comprises the rhythmic bilateral stimulation applied to both halves of the body sequentially.
  • the rhythmic bilateral stimulation is indicated to provide relaxation. It is thought to increase the consistence and coordination between the cerebral hemispheres (NovoNavarro P, Landin-Romero R, Guardiola- Wanden-Berghe R, Moreno-Alcazar A, Valiente-Gomez A, Lupo W, Garcia F, Fernandez I, Perez V, Amann BL. 25 years of Eye Movement Desensitization and Reprocessing (EMDR): The EMDR therapy protocol, hypotheses of its mechanism of action and a systematic review of its efficacy in the treatment of post-traumatic stress disorder. Rev Psiquiatr Salud Ment.
  • EMDR eye movement desensitization and reprocessing
  • EMDR actually includes bilateral stimulation.
  • the bilateral stimulation can occur in a variety of forms, including left-right eye movements, tapping on the knees, using headphones, or with handheld buzzers known as tappers (Gainer D, Alam S, Alam H, Redding H.
  • tappers Glass D, Alam S, Alam H, Redding H.
  • a FLASH OF HOPE Eye Movement Desensitization and Reprocessing (EMDR) Therapy. Innov Clin Neurosci. 2020 Jul 1; 17(7-9):12-20).
  • Another different form of the method could include the application of the transcranial stimulations in a manner similar to the EMDR principles.
  • the electrical stimulation may be applied in a bilateral symmetric manner (both temporal and spatial) and equally to both halves of the body sequentially.
  • vagus nerve stimulation was approved by FDA (Food and Drug Administration) in 1997 for treatment-resistant epilepsy and in 2005 for treatment-resistant depression.
  • the vagus nerve is the 10 th cranial nerve and the most important component of the parasympathetic nervous system.
  • the mechanism of action for the vagus nerve stimulation is still not well understood, it is believed to affect the cerebral blood flow and neural activity through the afferent fibers. Since the invasive vagus stimulation also affects the efferent fibers via the cervical area, it is possible to perform the stimulation unilaterally, and in this case, the risk for side effects is greater compared to the afferent stimulations, besides the surgical complications.
  • auricular vagus nerve stimulation is often performed unilaterally similar to the cervical application; however the simultaneous activation of the left and right auricular vagus nerve may potentially increase the effects of stimulation due to the increased sensory input to the brain stem (Kaniusas E, Kampusch S, Tittgemeyer M, Panetsos F, Gines RF, Papa M, Kiss A, Podesser B, Cassara AM, Tanghe E, Samoudi AM, Tarnaud T, Joseph W, Marozas V, Lukosevicius A, Istuk N, Sarolic A, Lechner S, Klonowski W, Varoneckas G, Szeles JC.
  • VNS auricular vagus nerve stimulation
  • various stimulation parameters may lead to different outcomes. Due to the complex physiology of the body, the strong and moderate levels of stimulation, in addition to the continuous and intermittent stimulation, may even cause negative physiological effects. It is alleged that the continuous vagus nerve stimulation (VNS) develops intense bradycardia and increased cardiac load conditions to an extent leading to the compensatory sympathetic reflexes. On the other hand, the intermittent VNS lacks a sufficient average intensity, and accordingly, the parasympathetic VNS is still able to antagonize the sympathetic system. Although it is clear that VNS or aVNS should be optimized according to a given dose and duty cycle, the principle of "as low as reasonably achievable" is valid for a certain therapeutic indication.
  • VNS or aVNS should not be chronic in order to attain sustainable therapeutic effects (Kaniusas E, Kampusch S, Tittgemeyer M, Panetsos F, Gines RF, Papa M, Kiss A, Podesser B, Cassara AM, Tanghe E, Samoudi AM, Tarnaud T, Joseph W, Marozas V, Lukosevicius A, Istuk N, Lechner S, Klonowski W, Varoneckas G, Szeles JC, Sarolic A. Current Directions in the Auricular Vagus Nerve Stimulation II - An Engineering Perspective. Front Neurosci. 2019 Jul 24; 13:772).
  • the system according to the invention comprises in its most basic form at least one stimulator (S), which generates the electric current to be delivered for the stimulation of the nerves, and at least one electrode (E), which enables the electric current generated by the stimulator (S) to be applied to the vagus nerve in the ear.
  • S stimulator
  • E electrode
  • the stimulation of the vagus nerve in both ears is performed.
  • This embodiment of the system has at least two electrodes (E) for transmitting the electric signals delivered by the stimulator (S) to each ear separately and/or simultaneously.
  • the system has at least two electrodes (E) for enabling the symmetric and sequential stimulation of the vagus nerve in the ear.
  • the electric signal is delivered to the vagus nerve from two different points of the ear.
  • This embodiment comprises at least two electrodes (E), one positioned to contact the concha section of the ear and the other positioned to contact the tragus section of the ear.
  • the embodiment where the vagus nerve stimulation is performed from two different points of the ear and where the vagus nerves located in both ears are stimulated comprises at least four electrodes (E).
  • the current is introduced from both ears via the system according to the invention.
  • the current is not simultaneously transmitted to ears and the sequential symmetric stimulation is performed.
  • the current is biphasic/bipolar.
  • the pulse width of the current is in the range of 100 microseconds-500 microseconds.
  • the current is applied for 0 to 15s to the right or left ear and then for 0 to 15s to the other ear.
  • No current is applied to any ear for 0-30s.
  • the current application times are equal for both ears.
  • the current properties other than the application time such as the pulse width, wave feature, and frequency range, may vary between the two ears.
  • the current frequency exhibits random or regular variation in the range of 1-30 Hz for both ears.
  • the current may have a sine, square, rectangular or triangular waveform.
  • a preferred embodiment of the invention comprises at least one ear hook (E2), which enables the electrode (E) to be positioned on the ear.
  • the ear hook (E2) has a geometry wrapping around the ear lobe to enable the electrode (E) to hang on the ear.
  • a preferred embodiment of the invention comprises at least one electrode carrier (El), on which the electrode (E) is fixed and which enables the electrode (E) to be moveably secured on the ear hook (E2).
  • the electrode carrier (El) is able to freely rotate around its own axis on the ear hook (E2) and thus, enables the electrodes (E) to be adjusted in the desired manner to suit the patient.
  • a preferred embodiment of the invention comprises at least one connection member (E3), which enables the electric current generated by the stimulator (S) to be conveyed to the electrodes (E).
  • Said connection member (E3) is preferably a cable.
  • the stimulator (S) comprises at least one visual warning member (SI), which enables the user to be informed about the status of the system.
  • said visual warning member (SI) is a luminescent member.
  • a preferred embodiment of the invention comprises at least one visual warning member (SI), which indicates whether the system is on or off, and/or at least one visual warning member (SI), which indicates the wireless connection status of the system, and/or at least one visual warning member (SI), which indicates the status of the stimulation.
  • none of the visual warning members (SI) lights up while the system is off and at least one of said members flashes when the system assumes the on position.
  • one of the visual warning members (SI) blinks while the wireless connection has not yet been established and the device to be connected is being searched and flashes when the connection has been established.
  • one of the visual warning members (SI) flashes during the period where the treatment has started and the stimulation is occurring and does not light up during the period where the stimulation does not occur or the treatment is in the off state.
  • a preferred embodiment of the invention comprises the visual warning member (SI), which indicates whether the system is on or off, and/or the visual warning member (SI), which indicates the wireless connection status of the system, and/or the visual warning member (SI), which indicates the status of the stimulation.
  • SI visual warning member
  • SI visual warning member
  • SI wireless connection status of the system
  • SI visual warning member
  • At least one setting component (S2) is present on the stimulator (S).
  • Said setting component (S2) enables at least one variable of the stimulator (S) to be set.
  • the switching on and off of the stimulator (S) is controlled via the setting component (S2).
  • the stimulator (S) is able to establish connection with at least one smart device.
  • said connection is provided in a wireless manner.
  • the parameters of the electric current generated by the stimulator (S) may be set through said smart device.
  • the variables such as the pulse width and/or frequency of the electric current to be applied to the nerve and/or the time for which the nerve is to be stimulated during the treatment and/or the time to be allowed to elapse after a stimulation before the next stimulation will occur and/or the overall time for which the treatment is to continue after the stimulation is started and/or the density of the electric current may be controlled via the stimulator (S) itself or via a smart device to which the stimulator (S) is connected.
  • the pulse width refers to the variable expressed in microseconds
  • the frequency refers to the variable expressed in hertz
  • the density refers to the variable expressed in milliamperes
  • time refers to the variable expressed in seconds.
  • the start and termination of the treatment are also controlled via the device itself or via a smart device.
  • the time to the end of the treatment may also be monitored via the smart device.
  • the smart device is a mobile phone or any electronic device capable of wireless communication.
  • the method of operation for the system according to the invention comprises in its most basic form the steps of; bringing the stimulator (S) into the on state, activating the wireless connection of the stimulator (S) and realizing the connection with at least one smart device in the embodiment where the stimulator is to be controlled via a wireless device, setting the stimulation parameters via the smart device and/or the device itself, and starting the stimulation and therefore the treatment.
  • some data about the patient are recorded before and after the stimulation and are stored in a database. Said data are classified as pre-stimulation and post-stimulation data. In a preferred embodiment of the invention, said data are in the form of questionnaires and/or biological data and/or voice records for the patient.
  • the data about the patient Prior to the stimulation, the data about the patient are acquired through a questionnaire, and the patient is subjected to biological measurements and voice analysis. The same procedures are repeated after the stimulation.
  • the data obtained prior to the stimulation, the personal data input and the database data are evaluated, the stimulation parameters are set according to the results obtained by running the artificial intelligence algorithms, and the stimulation is performed. After the stimulation, the data collected prior to the stimulation are measured again and said data are entered in the database as database data.
  • the variables such as the pulse width and/or frequency of the electric current to be applied to the nerve and/or the time for which the nerve is to be stimulated during the treatment and/or the time to be allowed to elapse after a stimulation before the next stimulation will occur and/or the overall time for which the treatment is to continue after the stimulation is started and/or the density of the electric current are set in the step of setting the stimulation parameters.
  • the pulse width refers to the variable expressed in microseconds
  • the frequency refers to the variable expressed in hertz
  • the density refers to the variable expressed in milliamperes
  • time refers to the variable expressed in seconds.
  • the pre-stimulation data of the patient, the personal data of the patient, the data of the other patients available in the database, and the post-stimulation data of the patient are evaluated to customize the stimulation parameters to be applied to the patient, i.e. to revise said parameters specifically for the patient. More specifically, the pre-stimulation and post-stimulation data of the patient are compared to the data of other patients available in the database and the optimum stimulation parameters determined for the other patients with similar data or the estimated stimulation parameters obtained as a result of the use of various algorithms are applied to the current patient, thereby enabling the efficacy of the treatment to be enhanced.
  • the pre-stimulation and post-stimulation data of the patient are also stored in the database and said data or inferences to be made from said data are used for the subsequent treatments of the same patient and/or for the treatments of the other patients.
  • the termination of the treatment may be performed manually via the smart device and/or the stimulator (S), while it is also possible for the treatment to automatically terminate at the end of the predetermined duration.
  • it may be enabled to deliver the current for a certain time during the treatment, then wait for a certain time without delivering any current, and deliver the current again at the end of said time.
  • the on/off periods may be set in said system and method.
  • the vagus nerve is stimulated via the ear area.
  • the vagus nerve passing through both ears is stimulated.
  • electrodes (E) are attached to both ears and the electric current is applied simultaneously and/or separately to both ears.
  • the electric current is transmitted to each ear via at least two points of the ear.
  • the vagus nerve stimulation is enabled by applying electric current to the concha and tragus sections of the ear.
  • the current may be applied simultaneously to both ears and/or to only one of the ears and the current may be optionally applied to each ear alternately and separately.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Electrotherapy Devices (AREA)

Abstract

L'invention concerne un système dans lequel les maladies et/ou les troubles sont traités par stimulation électrique du nerf vague auriculaire, et un procédé de fonctionnement dudit système. Plus spécifiquement, l'invention concerne un système dans lequel la stimulation du nerf vague est activée par l'intermédiaire de la branche auriculaire dudit nerf avec les paramètres électriques possibles à régler en fonction des besoins du patient pour ainsi traiter les maladies et/ou les troubles, et un procédé de fonctionnement dudit système.
PCT/TR2023/050071 2022-02-04 2023-01-30 Système dans lequel le traitement de maladies et de troubles est réalisé par stimulation électrique de nerfs et procédé de fonctionnement pour ledit système Ceased WO2023149857A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2022/001477 TR2022001477Y (tr) 2022-02-04 Hastalik ve rahatsizliklarin tedavi̇si̇ni̇n si̇ni̇rleri̇n elektri̇ksel uyarimi i̇le gerçekleşti̇ri̇ldi̇ği̇ bi̇r si̇stem ve si̇stemi̇n çalişma yöntemi̇
TR2022001477 2022-02-04

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WO2023149857A1 true WO2023149857A1 (fr) 2023-08-10

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PCT/TR2023/050071 Ceased WO2023149857A1 (fr) 2022-02-04 2023-01-30 Système dans lequel le traitement de maladies et de troubles est réalisé par stimulation électrique de nerfs et procédé de fonctionnement pour ledit système

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025083560A1 (fr) * 2023-10-16 2025-04-24 Cogniguard Medical Holdings Limited Stimulation du nerf vague

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190351230A1 (en) * 2014-06-13 2019-11-21 Neuvana, Llc Transcutaneous electrostimulator and methods for electric stimulation
US20200094054A1 (en) * 2018-09-24 2020-03-26 Vivek Sharma Auricular nerve stimulation to address patient disorders, and associated systems and methods
WO2020150737A1 (fr) * 2019-01-18 2020-07-23 Ist, Llc Procédés et dispositifs de modulation de réseaux neuronaux intégrés pour influencer des processus sensoriels composites

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190351230A1 (en) * 2014-06-13 2019-11-21 Neuvana, Llc Transcutaneous electrostimulator and methods for electric stimulation
US20200094054A1 (en) * 2018-09-24 2020-03-26 Vivek Sharma Auricular nerve stimulation to address patient disorders, and associated systems and methods
WO2020150737A1 (fr) * 2019-01-18 2020-07-23 Ist, Llc Procédés et dispositifs de modulation de réseaux neuronaux intégrés pour influencer des processus sensoriels composites

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025083560A1 (fr) * 2023-10-16 2025-04-24 Cogniguard Medical Holdings Limited Stimulation du nerf vague

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